haplorhini

Summary

Summary: A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHIDAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).

Top Publications

  1. ncbi Parietal lobe: from action organization to intention understanding
    Leonardo Fogassi
    Dipartimento di Psicologia, Universita di Parma, Borgo Carissimi 10, 43100 Parma, Italy
    Science 308:662-7. 2005
  2. ncbi A recurrent network mechanism of time integration in perceptual decisions
    Kong Fatt Wong
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 26:1314-28. 2006
  3. pmc Internal models of eye movement in the floccular complex of the monkey cerebellum
    S G Lisberger
    Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, Box 0444, 513 Parnassus Avenue, Room HSE 802, San Francisco, CA 94143 0444, USA
    Neuroscience 162:763-76. 2009
  4. ncbi Basal anthropoids from Egypt and the antiquity of Africa's higher primate radiation
    Erik R Seiffert
    Department of Earth Sciences, University of Oxford, and Oxford University Museum of Natural History, Parks Road, Oxford, OX1 3PW, UK
    Science 310:300-4. 2005
  5. ncbi The cortical motor system
    G Rizzolatti
    Istituto di Fisiologia Umana, Universita di Parma, Via Volturno 39, I43100 Parma, Italy
    Neuron 31:889-901. 2001
  6. pmc Rotavirus infection activates the UPR but modulates its activity
    Jose Luis Zambrano
    Immunology and Infectious Diseases, Montana State University, Bozeman, MT 59718, USA
    Virol J 8:359. 2011
  7. ncbi Evolution of eye size and shape in primates
    Callum F Ross
    Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    J Hum Evol 52:294-313. 2007
  8. ncbi Plasmodium knowlesi: a malaria parasite of monkeys and humans
    William E Collins
    Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Entomol 57:107-21. 2012
  9. ncbi A role for neural integrators in perceptual decision making
    Mark E Mazurek
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and National Primate Research Center, University of Washington, Seattle, WA 98195 7290, USA
    Cereb Cortex 13:1257-69. 2003
  10. pmc New perspectives on anthropoid origins
    Blythe A Williams
    Department of Evolutionary Anthropology, Duke University, Durham, NC 27708 0383, USA
    Proc Natl Acad Sci U S A 107:4797-804. 2010

Research Grants

  1. DEVELOPMENT OF THE CORTICOTHALAMIC SYSTEM
    Edward Jones; Fiscal Year: 2003
  2. CORTICAL ACTIVITY DURING INDIVIDUATED MOVEMENT
    Marc Schieber; Fiscal Year: 2002
  3. NEURONAL POPULATIONS PARTICIPATING IN MOTORIC CHOICES
    Marc Schieber; Fiscal Year: 2004
  4. ACTIVITY-DEPENDENT PLASTICITY IN SENSORY CORTEX
    Edward Jones; Fiscal Year: 2004
  5. Randomized Controlled Trial of Pediatric CI Therapy
    Edward Taub; Fiscal Year: 2006
  6. Visual Target Selection for Saccadic Eye Movements
    Michele Basso; Fiscal Year: 2007
  7. A TREATMENT FOR EXCESS MOTOR DISABILITY IN THE AGED
    Edward Taub; Fiscal Year: 2007
  8. Complete Proteome of Cerebrospinal Fluid
    Steven Schutzer; Fiscal Year: 2006
  9. Object-Centered Eye-Movement Signals in the Cortex
    Carl Olson; Fiscal Year: 2004
  10. ASSAY TO DETECT ACUTE ACTIVE LYME DISEASE
    Steven Schutzer; Fiscal Year: 2005

Detail Information

Publications242 found, 100 shown here

  1. ncbi Parietal lobe: from action organization to intention understanding
    Leonardo Fogassi
    Dipartimento di Psicologia, Universita di Parma, Borgo Carissimi 10, 43100 Parma, Italy
    Science 308:662-7. 2005
    ..Thus, these neurons not only code the observed motor act but also allow the observer to understand the agent's intentions...
  2. ncbi A recurrent network mechanism of time integration in perceptual decisions
    Kong Fatt Wong
    Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 26:1314-28. 2006
    ..Our reduced two-variable neural model offers a simple yet biophysically plausible framework for studying perceptual decision making in general...
  3. pmc Internal models of eye movement in the floccular complex of the monkey cerebellum
    S G Lisberger
    Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, Box 0444, 513 Parnassus Avenue, Room HSE 802, San Francisco, CA 94143 0444, USA
    Neuroscience 162:763-76. 2009
    ..Perhaps the insights from studying oculomotor control provide groundwork to guide the analysis of internal models for a wide variety of cerebellar behaviors...
  4. ncbi Basal anthropoids from Egypt and the antiquity of Africa's higher primate radiation
    Erik R Seiffert
    Department of Earth Sciences, University of Oxford, and Oxford University Museum of Natural History, Parks Road, Oxford, OX1 3PW, UK
    Science 310:300-4. 2005
    ....
  5. ncbi The cortical motor system
    G Rizzolatti
    Istituto di Fisiologia Umana, Universita di Parma, Via Volturno 39, I43100 Parma, Italy
    Neuron 31:889-901. 2001
    ..We submit that generating internal representations of actions is central to cortical motor function. External contingencies and motivational factors determine then whether these action representations are transformed into actual actions...
  6. pmc Rotavirus infection activates the UPR but modulates its activity
    Jose Luis Zambrano
    Immunology and Infectious Diseases, Montana State University, Bozeman, MT 59718, USA
    Virol J 8:359. 2011
    ..We also sought to identify proteins outside the IFN induction and signaling pathway that were modulated by rotavirus infection...
  7. ncbi Evolution of eye size and shape in primates
    Callum F Ross
    Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    J Hum Evol 52:294-313. 2007
    ..These data support the conclusion that the origin of anthropoids was associated with a change in eye shape to improve visual acuity in the context of a diurnal predatory habitus...
  8. ncbi Plasmodium knowlesi: a malaria parasite of monkeys and humans
    William E Collins
    Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Entomol 57:107-21. 2012
    ..The parasite was a major monkey animal model for developing antimalarial vaccines and investigations of the biology of parasite invasion. P. knowlesi is the first monkey malaria parasite genome to be sequenced and annotated...
  9. ncbi A role for neural integrators in perceptual decision making
    Mark E Mazurek
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, and National Primate Research Center, University of Washington, Seattle, WA 98195 7290, USA
    Cereb Cortex 13:1257-69. 2003
    ..The model explains a variety of behavioral and physiological measurements obtained from monkeys...
  10. pmc New perspectives on anthropoid origins
    Blythe A Williams
    Department of Evolutionary Anthropology, Duke University, Durham, NC 27708 0383, USA
    Proc Natl Acad Sci U S A 107:4797-804. 2010
    ..Progress in comparative anatomy, genomics, and molecular biology point to key changes in sensory ecology and brain organization that ultimately set the stage for the emergence of the human lineage...
  11. ncbi Parieto-frontal coding of reaching: an integrated framework
    Y Burnod
    INSERM CREARE U 483, UPMC, 9 Quai St Bernard, Paris F 75005, France
    Exp Brain Res 129:325-46. 1999
    ..This will result in a progressive match of retinal, gaze, arm, and muscle signals suitable for moving the hand toward the target...
  12. ncbi Gamma-band synchronization in visual cortex predicts speed of change detection
    Thilo Womelsdorf
    FC Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    Nature 439:733-6. 2006
    ....
  13. ncbi Parabolic movement primitives and cortical states: merging optimality with geometric invariance
    Felix Polyakov
    Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Biol Cybern 100:159-84. 2009
    ..We thus suggest that the cortical representation of movements is state-dependent and that parabolic elements are building blocks used by the motor system to generate complex movements...
  14. ncbi From monkeys to humans: what do we now know about brain homologies?
    Martin I Sereno
    Department of Cognitive Sciences, University of California, San Diego, La Jolla, CA 92093 0515, USA
    Curr Opin Neurobiol 15:135-44. 2005
    ....
  15. ncbi AIDS as a zoonosis: scientific and public health implications
    B H Hahn
    Department of Medicine, Howard Hughes Medical Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Science 287:607-14. 2000
    ..The implications of human infection by a diverse set of SIVs and of exposure to a plethora of additional human immunodeficiency virus-related viruses are discussed...
  16. ncbi Retinopathy in monkeys with spontaneous type 2 diabetes
    Sahng Y Kim
    Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 9115, USA
    Invest Ophthalmol Vis Sci 45:4543-53. 2004
    ..The purpose of this study was to investigate clinically and histopathologically the ocular changes in these monkeys...
  17. pmc Multidimensional recording (MDR) and data sharing: an ecological open research and educational platform for neuroscience
    Yasuo Nagasaka
    Laboratory for Adaptive Intelligence, BSI, RIKEN, Saitama, Japan
    PLoS ONE 6:e22561. 2011
    ..org. These recording and sharing methods support an ecological system that is open to everyone and will be a valuable and powerful research/educational platform for understanding the dynamic mechanisms of neural networks...
  18. pmc Feature- and order-based timing representations in the frontal cortex
    Aldo Genovesio
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD 20892, USA
    Neuron 63:254-66. 2009
    ..By representing stimulus durations and relative durations--both bound to stimulus features and event order--the frontal cortex could contribute to both temporal perception and episodic memory...
  19. ncbi Spatial memory and the monkey hippocampus: not all space is created equal
    Pamela Banta Lavenex
    Laboratory of Brain and Cognitive Development, Department of Medicine, Unit of Physiology, University of Fribourg, FR 1700, Switzerland
    Hippocampus 19:8-19. 2009
    ..Finally, we conclude that the available data demonstrate unequivocally that the central role of the hippocampus in allocentric, spatial relational learning and memory is conserved among vertebrates, including nonhuman primates...
  20. pmc Emergence of a novel and highly divergent HTLV-3 in a primate hunter in Cameroon
    Haoqiang Zheng
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 401:137-45. 2010
    ....
  21. pmc Anthropoid primates from the Oligocene of Pakistan (Bugti Hills): data on early anthropoid evolution and biogeography
    Laurent Marivaux
    Laboratoire de Paléontologie, Institut des Sciences de l Evolution de Montpellier, Unité Mixte de Recherche Centre National de la Recherche Scientifique 5554, c c 064, Universite Montpellier II, Montpellier, France
    Proc Natl Acad Sci U S A 102:8436-41. 2005
    ..These fossils provide data on temporal and paleobiogeographic aspects of early anthropoid evolution and significantly expand the record of stem anthropoid evolution in the Paleogene of South Asia...
  22. ncbi The prefrontal cortex: response selection or maintenance within working memory?
    J B Rowe
    Wellcome Department of Cognitive Neurology, Institute of Neurology, 12 Queen Square, London WC1N 3BG, UK
    Science 288:1656-60. 2000
    ..This accounts for the fact that this area is activated both when subjects select between items on working memory tasks and when they freely select between movements on tasks of willed action...
  23. pmc Object representations in the temporal cortex of monkeys and humans as revealed by functional magnetic resonance imaging
    Andrew H Bell
    Laboratory of Brain and Cognition, National Institute of Mental Health, 49 Convent Dr, Bethesda, MD 20892, USA
    J Neurophysiol 101:688-700. 2009
    ..In addition, they further support the idea that representations of complex stimuli in IT cortex are organized into multiple hierarchical tiers, encompassing both semantic and physical properties...
  24. pmc Mapping of the preferred direction in the motor cortex
    Apostolos P Georgopoulos
    Brain Sciences Center, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Proc Natl Acad Sci U S A 104:11068-72. 2007
    ..These findings provide evidence for an orderly mapping of the preferred direction in the motor cortex...
  25. ncbi Characterization of a nuclear deformed epidermal autoregulatory factor-1 (DEAF-1)-related (NUDR) transcriptional regulator protein
    J I Huggenvik
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale 62901 6523, USA
    Mol Endocrinol 12:1619-39. 1998
    ..The sequence and functional similarities between NUDR and DEAF-1 suggest that NUDR may also act as a cofactor to regulate the transcription of genes during fetal development or differentiation of testicular cells...
  26. pmc Decision-making with multiple alternatives
    Anne K Churchland
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, National Primate Research Center, University of Washington Medical School, Seattle, Washington 98195, USA
    Nat Neurosci 11:693-702. 2008
    ..These physiological observations constitute an effective strategy for handling increased task difficulty. The differences appear to explain subjects' accuracy and reaction times...
  27. ncbi Progress and prospects: naked DNA gene transfer and therapy
    H Herweijer
    Mirus Corporation and University of Wisconsin Madison, Madison, WI 53705, USA
    Gene Ther 10:453-8. 2003
    ..The availability of plasmid DNA expression vectors that enable sustained high level expression, allows for the development of gene therapies based on the delivery of naked plasmid DNA...
  28. ncbi Retrospective and prospective persistent activity induced by Hebbian learning in a recurrent cortical network
    Gianluigi Mongillo
    Dipartimento di Fisiologia Umana, Universita di Roma La Sapienza, Rome, Italy INFM, Dipartimento di Fisica, Universita di Roma La Sapienza, Rome, Italy
    Eur J Neurosci 18:2011-24. 2003
    ....
  29. pmc Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay
    Mark E Shaneyfelt
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59715, USA
    Virol J 3:68. 2006
    ....
  30. ncbi Late middle Eocene epoch of Libya yields earliest known radiation of African anthropoids
    Jean Jacques Jaeger
    Institut International de Paléoprimatologie et Paléontologie humaine, Évolution et Paléoenvironnements, CNRS UMR 6046, Universite de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
    Nature 467:1095-8. 2010
    ....
  31. pmc Valuation of uncertain and delayed rewards in primate prefrontal cortex
    Soyoun Kim
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Neural Netw 22:294-304. 2009
    ..These results show that the primate lateral prefrontal cortex plays a central role in estimating the values of alternative actions based on multiple sources of information...
  32. ncbi PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23
    Zubair M Ahmed
    Section of Human Genetics, Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD, USA
    Hum Mol Genet 12:3215-23. 2003
    ..Our results further strengthen the importance of protocadherin 15 in the morphogenesis and cohesion of stereocilia bundles and retinal photoreceptor cell maintenance or function...
  33. pmc Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade
    Shin Ichiro Tachibana
    Laboratory of Malariology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Nat Genet 44:1051-5. 2012
    ..The sequencing of the P. cynomolgi genome is a critical step in developing a model system for P. vivax research and in counteracting the neglect of P. vivax...
  34. ncbi Modulation of multidrug resistance protein (MRP1/ABCC1) expression: a novel physiological role for ouabain
    R C Valente
    Instituto de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Cell Biol Toxicol 23:421-7. 2007
    ....
  35. ncbi Rearrangement of receptive field topography after intracortical and peripheral stimulation: the role of plasticity in inhibitory pathways
    George J Kalarickal
    Department of Computer Science, University of North Carolina at Chapel Hill, USA
    Network 13:1-40. 2002
    ..It is shown that lateral inhibitory pathway plasticity is sufficient to model RF changes and increase in position discrimination after peripheral stimulation. Several novel and testable predictions are made based on the EXIN model...
  36. ncbi Language evolution: semantic combinations in primate calls
    Kate Arnold
    School of Psychology, University of St Andrews, St Andrews KY16 9JP, UK
    Nature 441:303. 2006
    ..Our findings indicate that non-human primates can combine calls into higher-order sequences that have a particular meaning...
  37. pmc Campbell's monkeys concatenate vocalizations into context-specific call sequences
    Karim Ouattara
    Laboratoire EthoS Ethologie Animale et Humaine, Unite Mixte de Recherche 6552, Centre National de la Recherche Scientifique, Universite de Rennes 1, Station Biologique, 35380 Paimpont, France
    Proc Natl Acad Sci U S A 106:22026-31. 2009
    ..As the different sequences were so tightly linked to specific external events, the Campbell's monkey call system may be the most complex example of 'proto-syntax' in animal communication known to date...
  38. ncbi Utilization of the Denny-Brown collection: differential recovery of forelimb and hind limb stepping after extensive unilateral cerebral lesions
    J A Vilensky
    Department of Anatomy, Indiana University School of Medicine, Fort Wayne 46805, USA
    Behav Brain Res 82:223-33. 1997
    ..This suggests that there is an underlying physiological basis to the widely-held belief that, in humans, lower limb recovery after stroke is generally more complete than that of the upper limb...
  39. ncbi Does skeletal anatomy reflect adaptation to locomotor patterns? Cortical and trabecular architecture in human and nonhuman anthropoids
    Colin N Shaw
    Department of Anthropology, The Pennsylvania State University, University Park, PA 16802, USA
    Am J Phys Anthropol 147:187-200. 2012
    ....
  40. pmc Relating neuronal firing patterns to functional differentiation of cerebral cortex
    Shigeru Shinomoto
    Graduate School of Science, Kyoto University, Sakyo ku, Kyoto, Japan
    PLoS Comput Biol 5:e1000433. 2009
    ..Thus, signaling patterns may play an important role in function-specific cerebral cortical computation...
  41. ncbi Involvement of the prefrontal cortex in problem solving
    Hajime Mushiake
    Department of Physiology, Tohoku University School of Medicine, 2 1 Seiryo cho, Aoba ku, Sendai 980 8575, Japan
    Int Rev Neurobiol 85:1-11. 2009
    ..Our data suggest that the PFC is involved primarily in the dynamic representation of multiple future events that occur as a consequence of behavioral actions in problem-solving situations...
  42. ncbi Measurement of variability dynamics in cortical spike trains
    Martin P Nawrot
    Bernstein Center for Computational Neuroscience Freiburg, Germany
    J Neurosci Methods 169:374-90. 2008
    ..Finally, we discuss the effect of several additional factors such as serial interval correlation and refractory period on the empiric relation of FF and CV(2)...
  43. pmc SINE insertions in cladistic analyses and the phylogenetic affiliations of Tarsius bancanus to other primates
    J Schmitz
    Primate Genetics, German Primate Center, Kellnerweg 4, D 37077 Gottingen, Germany
    Genetics 157:777-84. 2001
    ..The three Alu insertions characterized underpin the monophyly of haplorhine primates (Anthropoidea and Tarsioidea) from a novel perspective...
  44. ncbi Comparative mapping of higher visual areas in monkeys and humans
    Guy A Orban
    Lab Neuro en Psychofysiologie, K U Leuven, Medical School, Campus Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Trends Cogn Sci 8:315-24. 2004
    ..In the long term, fMRI offers opportunities to compare the functional anatomy of a variety of cognitive functions in the two species...
  45. pmc Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity
    Joseph E Rabinowitz
    Gene Therapy Center Laboratoire de Thérapie Génique, CHU Hotel Dieu, 44035 Nantes Cedex 01, France
    J Virol 76:791-801. 2002
    ..The development of these helper plasmids should facilitate direct comparisons of serotypes, as well as begin the standardization of production for further clinical development...
  46. pmc Synaptic computation underlying probabilistic inference
    Alireza Soltani
    Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Neurosci 13:112-9. 2010
    ....
  47. ncbi Independent and redundant information in nearby cortical neurons
    D S Reich
    Laboratory of Biophysics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 294:2566-8. 2001
    ..Redundancy was independent of cluster size. Summing neuronal responses to reduce variability discards potentially useful information, and the discarded information increases with cluster size...
  48. ncbi Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function
    Erwan Bezard
    Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, Universite Victor Segalen, 33076 Bordeaux, France
    Nat Med 9:762-7. 2003
    ....
  49. pmc Bionomics of Anopheles latens in Kapit, Sarawak, Malaysian Borneo in relation to the transmission of zoonotic simian malaria parasite Plasmodium knowlesi
    Cheong H Tan
    Infectious Diseases Research Centre, Institute for Medical Research Jalan Pahang, 50588 Kuala Lumpur, Malaysia
    Malar J 7:52. 2008
    ..A study was initiated to identify the vectors of malaria, to elucidate where transmission is taking place and to understand the bionomics of the vectors in Kapit...
  50. ncbi Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes
    J A McCart
    Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892-1502, USA
    Cancer Res 61:8751-7. 2001
    ..It is a promising vector for use in tumor-directed gene therapy, given its enhanced safety profile, tumor selectivity, and the oncolytic effects after systemic delivery...
  51. ncbi A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction
    Melvyn W Yap
    Division of Virology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Curr Biol 15:73-8. 2005
    ..A single amino acid substitution (R332P) in the human Trim5alpha can confer the ability to restrict HIV-1, suggesting that small changes during evolution may have profound effects on our susceptibility to cross-species infection...
  52. pmc Discovery of novel human and animal cells infected by the severe acute respiratory syndrome coronavirus by replication-specific multiplex reverse transcription-PCR
    Laura Gillim-Ross
    Wadsworth Center, New York State Department of Health, 120 New Scotland Ave, Albany, NY 12208, USA
    J Clin Microbiol 42:3196-206. 2004
    ..Our data and other in vivo studies indicate that SARS-CoV has a wide host range, suggesting that the cellular receptor(s) utilized by SARS-CoV is highly conserved and is expressed by a variety of tissues...
  53. ncbi Target selection in area V4 during a multidimensional visual search task
    Tadashi Ogawa
    Division of Sensory and Cognitive Information, National Institute for Physiological Sciences, Okazaki, Aichi 444 8585, Japan
    J Neurosci 24:6371-82. 2004
    ....
  54. ncbi Neuroscience. Predicting future rewards
    Barry J Richmond
    Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892, USA
    Science 301:179-80. 2003
  55. ncbi Linear vestibular self-motion signals in monkey medial superior temporal area
    F Bremmer
    Department of Zoology and Neurobiology, Ruhr University Bochum, Germany
    Ann N Y Acad Sci 871:272-81. 1999
    ..The remaining 25% (5/20) preferred directions that were antialigned. Our results provide strong evidence that neurons in the MST area are at least in part involved in the processing of self-motion...
  56. ncbi Endocytosis by random initiation and stabilization of clathrin-coated pits
    Marcelo Ehrlich
    Department of Cell Biology, Harvard Medical School and the CBR Institute for Biomedical Research, 200 Longwood Avenue, Boston, MA 02115, USA
    Cell 118:591-605. 2004
    ..Cargo incorporation occurs primarily or exclusively in a newly formed coated pit. Our data lead to a model in which coated pits initiate randomly but collapse unless stabilized, perhaps by cargo capture...
  57. pmc Structure and function of declarative and nondeclarative memory systems
    L R Squire
    Veterans Affairs Medical Center, San Diego, La Jolla, CA 92161, USA
    Proc Natl Acad Sci U S A 93:13515-22. 1996
    ....
  58. pmc Neural mechanism for stochastic behaviour during a competitive game
    Alireza Soltani
    Department of Physics and Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, USA
    Neural Netw 19:1075-90. 2006
    ..Finally, when combined with a meta-learning algorithm, our model accounts for the slow drift in the animal's strategy based on a process of reward maximization...
  59. pmc A neural circuit model of flexible sensorimotor mapping: learning and forgetting on multiple timescales
    Stefano Fusi
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuron 54:319-33. 2007
    ..This model prediction is confirmed by monkey data. Therefore, our work reveals a scenario for conditional associative learning that is distinct from instant switching between sets of well-established sensorimotor associations...
  60. ncbi Impact of learning on representation of parts and wholes in monkey inferotemporal cortex
    Chris I Baker
    Center for the Neural Basis of Cognition, 115 Mellon Institute, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nat Neurosci 5:1210-6. 2002
    ..These results indicate a possible neural mechanism for holistic or configural effects in expert versus novice observers...
  61. ncbi The role of cortical area MST in a model of combined smooth eye-head pursuit
    P W Dicke
    Department of Neurology, University of Tubingen, Germany
    Biol Cybern 80:71-84. 1999
    ..Since only isodirectional hidden units contributed to the flow of information, the preponderance of isodirectional MSTl-VT neurons might be the result of developmental pruning, eliminating the second group...
  62. ncbi Neuronal correlates of perceptual stability during eye movements
    Peter W Dicke
    Center for Neurology, Hertie Institute for Clinical Brain Research, Department of Cognitive Neurology, University of Tuebingen, Otfried Mueller Str 27, 72076 Tuebingen, Germany
    Eur J Neurosci 27:991-1002. 2008
    ....
  63. pmc Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed
    Vincent H J Leonard
    Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Clin Invest 118:2448-58. 2008
    ..Thus, EpR is probably a basolateral protein, and infection of the airway epithelium is not essential for systemic spread and virulence of MV...
  64. ncbi Detecting precise firing sequences in experimental data
    M Abeles
    Department of Physiology and Interdisciplinary Center for Neural Computation, The Hebrew University, PO Box 12272, 91 120, Jerusalem, Israel
    J Neurosci Methods 107:141-54. 2001
    ..Pitfalls which may cause false detection of PFSs, or loss of existing PFSs, include searching for PFSs in which the same neuron participates more than once, and attempting to produce a surrogate with some fixed statistical property...
  65. ncbi In vitro antiplasmodial activity and cytotoxicity of crude extracts and compounds from the stem bark of Kigelia africana (Lam.) Benth (Bignoniaceae)
    Denis Zofou
    Biotechnology Unit, University of Buea, P O Box 63 Buea, South West Region, Cameroon
    Parasitol Res 108:1383-90. 2011
    ..These findings justify the use of K. africana stem bark as antimalaria by traditional healers of Western Cameroon, and could constitute a good basis for further studies towards development of new leads or natural drugs for malaria...
  66. ncbi Comparison of local measures of spike time irregularity and relating variability to firing rate in motor cortical neurons
    Adrián Ponce-Alvarez
    Institut de Neurosciences Cognitives de la Mediterranee, CNRS Université de la Méditerranée, Marseille, France
    J Comput Neurosci 29:351-65. 2010
    ..Neurons with a CV(2)-rate decoupling have a rather constant CV(2) and discharge mainly irregularly. Neurons with a CV(2)-rate coupling can modulate their CV(2) and explore a larger range of CV(2) values...
  67. pmc Risk to human health from a plethora of simian immunodeficiency viruses in primate bushmeat
    Martine Peeters
    Institue de Recherche pour la Développement, Laboratoire Retrovirus, 911 Avenue Agropolis, BP 5045, 34032 Montpellier Cedex 1, France
    Emerg Infect Dis 8:451-7. 2002
    ..These data document for the first time that a substantial proportion of wild monkeys in Cameroon are SIV infected and that humans who hunt and handle bushmeat are exposed to a plethora of genetically highly divergent viruses...
  68. ncbi Differences in spiking patterns among cortical neurons
    Shigeru Shinomoto
    Department of Physics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Neural Comput 15:2823-42. 2003
    ..This suggests that neurons in each area can be classified into different groups possessing unique spiking statistics and corresponding functional properties...
  69. pmc Simian T-cell leukemia virus (STLV) infection in wild primate populations in Cameroon: evidence for dual STLV type 1 and type 3 infection in agile mangabeys (Cercocebus agilis)
    Valerie Courgnaud
    UR36, IRD, and University of Montpellier I, Montpellier, France
    J Virol 78:4700-9. 2004
    ....
  70. ncbi Unitary events in multiple single-neuron spiking activity: II. Nonstationary data
    Sonja Grün
    Department of Neurophysiology, Max Planck Institute for Brain Research, D 60528 Frankfurt Main, Germany
    Neural Comput 14:81-119. 2002
    ..The potential of the new method is illustrated by results from multiple single-unit recordings from frontal and motor cortical areas in awake, behaving monkey...
  71. ncbi Identification and molecular characterization of new STLV-1 and STLV-3 strains in wild-caught nonhuman primates in Cameroon
    Florian Liegeois
    UMR 145, Institut de Recherche pour le Developpement IRD and University of Montpellier 1, Montpellier, France
    Virology 371:405-17. 2008
    ..cephus. Finally, we identify relative divergence levels in the tax/rex phylogeny suggesting that additional types of PTLV should be defined, particularly for the highly divergent STLV-1(MarB43) strain that we provisionally name STLV-5...
  72. pmc New multiple antigenic peptide-based enzyme immunoassay for detection of simian immunodeficiency virus infection in nonhuman primates and humans
    C B Ndongmo
    Division of AIDS, STD, and TB Laboratory, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 42:5161-9. 2004
    ..As shown with SIV-infected talapoin monkeys, this assay has the potential to detect previously unidentified SIV strains and should be suitable for sentinel surveillance for potential new cross-species transmissions of SIVs to humans...
  73. ncbi Variability in neuronal activity in primate cortex during working memory tasks
    M Shafi
    Neuropsychiatric Institute, 760 Westwood Plaza, School of Medicine, University of California, Los Angeles, CA 90095 1759, USA
    Neuroscience 146:1082-108. 2007
    ..These results may serve as a guide in the evaluation of current theories of the cortical mechanisms of working memory...
  74. ncbi Big bang in the evolution of extant malaria parasites
    Toshiyuki Hayakawa
    Laboratory of Malariology, International Research Center of Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Mol Biol Evol 25:2233-9. 2008
    ..Interestingly, the rapid diversification coincides with the radiation of the mammalian genera, suggesting that adaptive radiation to new mammalian hosts triggered the rapid diversification of extant malaria parasite lineages...
  75. ncbi Decoding spike trains instant by instant using order statistics and the mixture-of-Poissons model
    Matthew C Wiener
    Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4415, USA
    J Neurosci 23:2394-406. 2003
    ..Most of the error in estimating stimulus probabilities is attributable to not having enough data to specify the parameters of the model rather than to misspecification of the model itself...
  76. pmc Central African hunters exposed to simian immunodeficiency virus
    Marcia L Kalish
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 11:1928-30. 2005
    ..001). One person had strong humoral and weak cellular immune reactivity to SIVcol peptides. Humans are exposed to and possibly infected with SIV, which has major public health implications...
  77. ncbi Touch and go: decision-making mechanisms in somatosensation
    R Romo
    Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, 04510 Mexico, D F Mexico
    Annu Rev Neurosci 24:107-37. 2001
    ..Responses recorded in motor areas seem to reflect the output of decision-making operations, which suggests that the ability to make decisions occurs at the sensory-motor interface...
  78. ncbi Genotyping of Giardia intestinalis from domestic and wild animals in Japan using glutamete dehydrogenase gene sequencing
    Tadashi Itagaki
    Laboratory of Veterinary Parasitology, Faculty of Agriculture, Iwate University, 3 18 8 Ueda, Morioka 020 0105, Japan
    Vet Parasitol 133:283-7. 2005
    ..This is the first report on the genotypes of Giardia isolates from cats, calves and wild monkeys in Japan...
  79. pmc Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease
    Chuan En Wang
    Department of Human Genetics, Emory University School ofMedicine, Atlanta, GA 30322, USA
    Hum Mol Genet 17:2738-51. 2008
    ....
  80. ncbi A triple mutation in the second transmembrane domain of mouse dopamine transporter markedly decreases sensitivity to cocaine and methylphenidate
    Rong Chen
    Department of Pharmacology, The Ohio State University College of Medicine, Columbus, Ohio, USA
    J Neurochem 94:352-9. 2005
    ..Such functional but cocaine-insensitive DAT mutants can be used to generate a knock-in mouse line to study the role of DAT in cocaine addiction...
  81. ncbi Problem of dural scarring in recording from awake, behaving monkeys: a solution using 5-fluorouracil
    R L Spinks
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, United Kingdom
    J Neurophysiol 90:1324-32. 2003
    ..It is also possible that this technique may be useful in other situations where there is dural scarring after surgical intervention or injury...
  82. ncbi Association of clathrin, AP-2 adaptor and actin cytoskeleton with developing interlocking membrane domains of lens fibre cells
    Cheng Jing Zhou
    Department of Anatomy and Neurobiology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Exp Eye Res 77:423-32. 2003
    ..The coordinated 'pulling and pushing' actions generated by the clathrin/AP-2 complex and branching actin networks during interlocking domain formation are discussed...
  83. ncbi Shotgun proteomic analysis of Chlamydia trachomatis
    Paul Skipp
    Centre for Proteomic Research, and School of Biological Sciences, University of Southampton, Southampton, UK
    Proteomics 5:1558-73. 2005
    ..Taken together, >/=35% of the predicted proteome for C. trachomatis has been experimentally verified, representing the most extensive survey of any chlamydial proteome to date...
  84. ncbi Segmental duplications and the evolution of the primate genome
    Rhea Vallente Samonte
    Department of Genetics and Center for Human Genetics, School of Medicine and University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Nat Rev Genet 3:65-72. 2002
    ..Although the precise fraction is unknown, some of these duplicated segments have recently been shown to be associated with rapid gene innovation and chromosomal rearrangement in the genomes of man and the great apes...
  85. pmc Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito's RNA interference pathway
    Irma Sanchez-Vargas
    Department of Microbiology, Arthropod Borne and Infectious Diseases Laboratory, Colorado State University, Fort Collins, Colorado, United States of America
    PLoS Pathog 5:e1000299. 2009
    ..Our findings indicate a major role for RNAi as a determinant of DENV transmission by Ae. aegypti...
  86. ncbi Turning on and off with excitation: the role of spike-timing asynchrony and synchrony in sustained neural activity
    B S Gutkin
    Unite de Neurosciences Intergratives et Computationelles, CNRS, Gif-sur-Yvette 91198, France
    J Comput Neurosci 11:121-34. 2001
    ..The activity that codes working memories may be structured so that the motor command is both the read-out and a direct clearing signal. We show examples of data that is compatible with our theory...
  87. ncbi The neural origins and implications of imitation, mirror neurons and tool use
    Atsushi Iriki
    RIKEN Brain Science Institute, Laboratory for Symbolic Cognitive Development, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Curr Opin Neurobiol 16:660-7. 2006
    ..Although tool-use training is patently non-naturalistic, its marked effects on brain organization and behavior could shed light on the evolution of higher intelligence in humans...
  88. pmc Optimal decoding of correlated neural population responses in the primate visual cortex
    Yuzhi Chen
    Department of Psychology and Center for Perceptual Systems, 1 University Station, A8000, University of Texas at Austin, Austin, Texas 78712, USA
    Nat Neurosci 9:1412-20. 2006
    ..Overall, our results suggest an unexpected role for inhibitory mechanisms in efficient decoding of neural population responses...
  89. ncbi Sensory-motor and cognitive functions of the human posterior parietal cortex involved in manual actions
    Sarah H Creem-Regehr
    Department of Psychology, University of Utah, Salt Lake City, UT 84112, USA
    Neurobiol Learn Mem 91:166-71. 2009
    ..Proposed theories of multiple dorsal stream systems supporting different action-relevant goals are discussed...
  90. ncbi Dynamics of depolarization and hyperpolarization in the frontal cortex and saccade goal
    Eyal Seidemann
    Department of Neurobiology and the Grodetsky Center for Studies of Higher Brain Function, Weizmann Institute of Science, Rehovot 76100, Israel
    Science 295:862-5. 2002
    ..During this hyperpolarization saccades are almost exclusively ipsilateral, suggesting an important role for hyperpolarization in determining saccade goal...
  91. ncbi Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs
    E C Brinkman-Van der Linden
    Glycobiology Research and Training Center and Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 275:8633-40. 2000
    ..Others showed that siglec-4a (myelin-associated glycoprotein) prefers Neu5Ac over Neu5Gc. Thus, the human loss of Neu5Gc may alter biological processes involving siglec-1, and possibly, siglec-4a or -5...
  92. ncbi Identification of a highly divergent HIV type 2 and proposal for a change in HIV type 2 classification
    Florence Damond
    Virology Department, Hopital Bichat, 75877 Paris 18, France
    AIDS Res Hum Retroviruses 20:666-72. 2004
    ..The single-strain lineages C to G and the 96FR12034 lineage identified here should be considered only as putative groups until related strains are identified that confirm circulation of these viruses in the human population...
  93. ncbi Task-related modulation in the monkey inferotemporal cortex
    Gyula Sary
    Department of Physiology, University of Szeged, H 6720, Dom ter 10, Szeged, Hungary
    Brain Res 1121:76-82. 2006
    ..It was found that behavioral relevance reduces the latency in the inferotemporal cortex and it was concluded that behavioral significance accelerates information processing. This effect has not been described previously...
  94. pmc Neurons of the cerebral cortex exhibit precise interspike timing in correspondence to behavior
    Tomer Shmiel
    Bar Ilan University, Ramat Gan 52900, Israel
    Proc Natl Acad Sci U S A 102:18655-7. 2005
    ..Here we show, in behaving monkeys, that time intervals between spikes, measured in correspondence to a specific behavior, may be controlled to within the milliseconds range...
  95. ncbi Metabolism of the new nonbenzodiazepine anxiolytic agent, RWJ-51204, in mouse, rat, dog, monkey and human hepatic S9 fractions, and in rats, dogs and humans
    W N Wu
    Johnson and Johnson Pharmaceutical Research and Development, LLC, Spring House, PA 19477, USA
    Eur J Drug Metab Pharmacokinet 29:263-8. 2004
    ..Pathways 2-4 formed minor/trace oxidized, and dehydrated metabolites. RWJ-51204 is extensively metabolized in vitro (except dog) and in vivo in rats, dogs and humans...
  96. ncbi Interspecies scaling of biliary excreted drugs: a comparison of several methods
    Iftekhar Mahmood
    Clinical Pharmacology and Toxicology Branch HFD 579, Office of Drug Evaluation VI, Center for Drug Evaluation and Research, Food and Drug Administration, Woodmont Office Center II, Rockville, Maryland 20852, USA
    J Pharm Sci 94:883-92. 2005
    ..The simple allometry and the monkey liver blood flow (MLBF) approaches gave almost similar results. For some drugs the simple allometry predicted clearance better than the MLBF approach and vice versa...
  97. ncbi Enantiomer ratio of MK-0767 in humans and nonclinical species
    Zhongzhou Shen
    Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ 07065, USA
    Rapid Commun Mass Spectrom 19:1125-9. 2005
    ....
  98. ncbi A mathematical description of the functionality of correction factors used in allometry for predicting human drug clearance
    Huadong Tang
    Department of Pharmaceutical Sciences, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA
    Drug Metab Dispos 33:1294-6. 2005
    ..However, ROE may still serve as a useful practical approach in predicting human CL since it was derived from real observations and has been applied to many examples...
  99. ncbi GB toxicity reassessed using newer techniques for estimation of human toxicity from animal inhalation toxicity data: new method for estimating acute human toxicity (GB)
    R W Bide
    Defence R and D Canada Suffield, Box 4000, Medicine Hat, Alberta, Canada T1A 8K6
    J Appl Toxicol 25:393-409. 2005
    ..These values are recommended for general use for the total human population. The empirical relationships employed in the calculations may not be valid for exposure times >30 min...
  100. ncbi Accuracy of allometrically predicted pharmacokinetic parameters in humans: role of species selection
    Huadong Tang
    Department of Pharmaceutical Sciences, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA
    Drug Metab Dispos 33:1288-93. 2005
    ..Appreciation of this species or weight dependence should guide researchers in selecting animal species and designing optimal experiments in the application of allometric scaling...
  101. ncbi Characterization of the Bex gene family in humans, mice, and rats
    Enrique Alvarez
    Medical Scientist Training Program, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Gene 357:18-28. 2005
    ..We conclude that the Bex gene family members are highly homologous but differ in their expression patterns, subcellular localization, and degradation by the proteasome...

Research Grants71

  1. DEVELOPMENT OF THE CORTICOTHALAMIC SYSTEM
    Edward Jones; Fiscal Year: 2003
    ..Defective maturation may be a concomitant of or a basis for certain forms of seizures in young individuals. ..
  2. CORTICAL ACTIVITY DURING INDIVIDUATED MOVEMENT
    Marc Schieber; Fiscal Year: 2002
    ..Finally, we will map M1 repeatedly during motor skill learning to determine (Aim 4) whether any spatial segregation diminishes as the M1 territories that provide output to trained muscles progressively enlarge and increasingly overlap. ..
  3. NEURONAL POPULATIONS PARTICIPATING IN MOTORIC CHOICES
    Marc Schieber; Fiscal Year: 2004
    ..inactivation or microstimulation of the PMv, SMA, and striatum bias motoric choices? (4) How do the partially overlapping cortico-striatal projections from the PMv and SMA correlate with striatal regions participating in motoric choices? ..
  4. ACTIVITY-DEPENDENT PLASTICITY IN SENSORY CORTEX
    Edward Jones; Fiscal Year: 2004
    ....
  5. Randomized Controlled Trial of Pediatric CI Therapy
    Edward Taub; Fiscal Year: 2006
    ..abstract_text> ..
  6. Visual Target Selection for Saccadic Eye Movements
    Michele Basso; Fiscal Year: 2007
    ..abstract_text> ..
  7. A TREATMENT FOR EXCESS MOTOR DISABILITY IN THE AGED
    Edward Taub; Fiscal Year: 2007
    ..abstract_text> ..
  8. Complete Proteome of Cerebrospinal Fluid
    Steven Schutzer; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  9. Object-Centered Eye-Movement Signals in the Cortex
    Carl Olson; Fiscal Year: 2004
    ..Series 4 will investigate whether neurons in the frontal eve field (FEF) carry object-centered signals. ..
  10. ASSAY TO DETECT ACUTE ACTIVE LYME DISEASE
    Steven Schutzer; Fiscal Year: 2005
    ..It can also detect infection early than free antibody assays. Therefore this assay can fulfill a great need in Lyme disease diagnosis and has high market potential. ..
  11. Development & Manufacture of an MDR Tuberculosis Vaccine
    Steven Reed; Fiscal Year: 2005
    ..This will enable us to immediately proceed to human clinical trials after the end of the funding period. ..
  12. Neural circuitry of the parietal lobe
    RALPH SIEGEL; Fiscal Year: 2006
    ....
  13. Detection of Virulent Burkholderia mallei
    Steven Schutzer; Fiscal Year: 2006
    ..In Phase 2 we will also develop the immuno-based assays. ..
  14. Framework for Modeling Human Cognition
    Carl Olson; Fiscal Year: 2006
    ....
  15. SYNAPTIC CONNECTIONS OF SPINAL CORD NEURONS
    William Willis; Fiscal Year: 2007
    ..Preliminary evidence supports the feasibility of the work and suggests that the results could lead to a number of new targets for improvements in pain therapy. ..
  16. SPATIAL FUNCTIONS OF THE MEDIAL TEMPORAL LOBE
    WENDY SUZUKI; Fiscal Year: 2008
    ..The results from these studies have implications for understanding a variety of neurological states associated with memory dysfunction including Alzheimer's disease, epilepsy and schizophrenia. ..
  17. CRCNS - Higher-Level Neural Specialization for Natural Shape Statistics
    CHARLES CONNOR; Fiscal Year: 2008
    ..abstract_text> ..
  18. Human T Cell Antigens of Mycobacterium tuberculosis
    Steven Reed; Fiscal Year: 2009
    ..Finally, we will test antigens/vaccine formulations in rodent models of infection and disease. By the end of the funding period, we will have defined a second vaccine candidate for entry into clinical trials. ..
  19. ANALYSIS OF STRUCTURE-FROM-MOTION IN VISUAL CORTEX
    RALPH SIEGEL; Fiscal Year: 2003
    ..These studies will be crucial in correctly choosing which parietal representations are best modified through therapy when there are spatial deficits in human subjects caused by parietal damage through stroke. ..
  20. NEURAL EFFECTS OF INTERFERENCE WITH WORKING MEMORY
    Clayton Curtis; Fiscal Year: 2002
    ..abstract_text> ..
  21. Assay to detect early neurologic Lyme disease
    Steven Schutzer; Fiscal Year: 2003
    ..BbIC Ab and Ag will be identified. Focus will be towards on specific and in vivo expressed Bb Ags. Results will be statistically analyzed. Phase 2 will be designed for broadscale usage and refinement. ..
  22. LIVE, ATTENUATED, RECOMBINANT VACCINE - WEST NILE VIRUS
    Thomas Monath; Fiscal Year: 2002
    ..abstract_text> ..
  23. Racial Variations in Optic Nerve Head Structure and Biomechanics
    J CRAWFORD contact DOWNS; Fiscal Year: 2011
    ....
  24. The Cortical Representation of Oculomotor Proprioception
    Michael Goldberg; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. NEUROBIOLOGICAL PARAMETERS OF COCAINE REINFORCEMENT
    Scott Hemby; Fiscal Year: 2008
    ..abstract_text> ..
  26. Functional Imaging of Decision Networks
    VINCENT FERRERA; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. Toward a Unified Model of Cognitive Control
    RANDALL O REILLY; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  28. OLFACTORY CORTEX
    Joseph Price; Fiscal Year: 2002
    ..By correlating the PET and MRI images, levels of metabolic and synaptic activity can be determined within the defined architectonic areas as a function of unipolar or bipolar depression. ..
  29. Chemoprevention Through Activation of Estrogen Receptor Alpha-Induced Senescence
    Harikrishna Nakshatri; Fiscal Year: 2007
    ..Our long- term goal is to identify molecular targets for senescence-based chemoprevention strategies for ERa-positive breast cancers. [unreadable] [unreadable] [unreadable]..
  30. Novel Brain Neuroimaging Markers of Age-Related Mobility Impairment
    Caterina Rosano; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  31. NEURAL CONTROL OF VERGENCE AND OCULAR ACCOMMODATION
    PAUL GAMLIN; Fiscal Year: 2001
    ....
  32. Molecular and Structural Bases of Hypothalamic Puberty
    TONY PLANT; Fiscal Year: 2009
    ....
  33. Visual and Auditory Processing Streams in the Cerebral Cortex
    Josef P Rauschecker; Fiscal Year: 2010
    ..abstract_text> ..
  34. Induction of HIV-specific Immune Responses
    Rajesh T Gandhi; Fiscal Year: 2010
    ..By understanding the mechanisms by which immune responses against HIV can be augmented, this may lead to improved ways of treating this disease and may help in developing a vaccine to prevent this infection. ..
  35. rTMS and Motor Learning Training to Promote Recovery from Hemiparesis
    James Carey; Fiscal Year: 2009
    ..The potential impact of this research is a radical change to rehabilitation that accomplishes a higher quality of life in stroke. ..
  36. Modulation of HIV-1 specific T cell function by TLR ligands
    Marcus Altfeld; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  37. 3D Reconstruction of Optic Nerve Heads
    J Downs; Fiscal Year: 2008
    ..Using these 3D reconstructions of the ONH and principles of biomechanical engineering, we can model the mechanical and vascular effects of elevated IOP in glaucoma. [unreadable] [unreadable] [unreadable]..
  38. METHYLATION PROFILING AND RISK OF COLORECTAL CANCER
    Hassan Ashktorab; Fiscal Year: 2007
    ..These studies will help in the detection and _rofiling of genetic changes in the pathway of CRC in AA. ..
  39. MODELING THE MENOPAUSAL TRANSITION AND MENOPAUSE
    JAY KAPLAN; Fiscal Year: 2008
    ..Therefore the proposed program is directly relevant to the missions of multiple NIHInstitutes, including - butnot limited to - NIA, NICHD, NHLBI, NIDDKand NIMH. ..
  40. LIGAND GATED ION CHANNELS AND ETOH DISCRIMINATION
    Kathleen Grant; Fiscal Year: 2001
    ..These findings will suggest variables that determine the effectiveness of pharmacological agents to block ethanol's stimulus effects, and may suggest the appropriate receptor system(s) to target. ..
  41. MULTIDIMENSIONAL DYNAMIC OF THE VESTIBULO OCULAR REFLEX
    Theodore Raphan; Fiscal Year: 2008
    ..When the study is completed, we will have a quantitative model of how the vestibular system contributes to maintenance of binocular gaze stability while moving. ..
  42. Fast and slow dopamine signaling in prefrontal cortex
    Jeremy Seamans; Fiscal Year: 2006
    ..A new theory will be proposed that incorporates fast and slow signaling from VTA neurons and that explains the existing literature while providing a new way to think about normal and pathological states involving PFC DA. ..
  43. Molecular Fingerprint of Cocaine Abuse Analysis
    Scott Hemby; Fiscal Year: 2003
    ..In addition, identification of differentially expressed genes may provide novel targets for the pharmacotherapeutic development and/or the refinement of existent pharmacotherapies. ..
  44. A Computational Facility for Neuroimaging Research
    Gregory McCarthy; Fiscal Year: 2003
    ..abstract_text> ..
  45. COOPERATIVE HUMORAL & CELLULAR IMMUNITY AGAINST HIV/SIV
    Dennis Burton; Fiscal Year: 2005
    ..This will provide us with the first opportunity to look at the effects of potent human mAbs on established infection in the presence of functional T cells. ..
  46. RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEM
    NEAL BARMACK; Fiscal Year: 2003
    ..abstract_text> ..
  47. Physiology of Lamina I and V STT Cells
    Arthur Craig; Fiscal Year: 2005
    ..This research will provide new insights into the synergy between lamina I and V STT neurons and into the integration underlying pain, temperature and itch sensations that is altered in clinical disorders. ..
  48. CELLULAR REGULATION OF TYROSINE HYDROXYLASE
    John Haycock; Fiscal Year: 2001
    ..The effects of haloperidol on Ser19, Ser3l, and Ser4O phosphorylation will be studied by immunohistochemical and blot immunolabeling procedures using site- and phosphorylation state-specific antibodies. ..
  49. Effects of Dietary Soy on Biomarkers in Prostate Cancer
    J Cline; Fiscal Year: 2004
    ..abstract_text> ..
  50. Mechanisms of Growth Inhibition by Helicobacter Pylor
    Hassan Ashktorab; Fiscal Year: 2003
    ..These studies will help to establish how bacteria can increase apoptosis possibly through generation of ROS and in specific circumstances this may alter one's risk of developing cancer. ..
  51. Role of Ang-(1-7) in normal and hypertensive pregnancy
    K Brosnihan; Fiscal Year: 2003
    ..The major goal of these studies is to understand the contribution of the vasodilator component of the RAAS to blood pressure regulation in normal pregnancy. ..
  52. STRUCTURE AND FUNCTION OF ROD AND CONE PIGMENTS
    Masahiro Kono; Fiscal Year: 2004
    ..These results will also be important in the understanding of the activation mechanisms of the larger field of G protein-coupled receptors. ..
  53. COGNITION AND ESTROGEN IN MIDDLE-AGED FEMALE MONKEYS
    Mary Lou Voytko; Fiscal Year: 2003
    ..The findings from these novel experiments in middle-aged monkeys will significantly advance our understanding of the effects of different ovarian hormone therapies on cognitive and neurobiological profiles of primates. ..
  54. Accumbens-pallidal GABA and morphine reinforcement
    Scott Hemby; Fiscal Year: 2005
    ..Changes in the expression levels of multiple genes will be assessed in terms of morphine reinforcement and direct pharmacological effects of the drug. ..
  55. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
    ..abstract_text> ..
  56. NEUROBIOLOGY OF PRIMATE SOCIAL BEHAVIOR
    David Amaral; Fiscal Year: 2002
    ..These studies will provide important insights into the neurobiology of normal social behavior and may contribute to an understanding of pathologies of social communication in disorders such as autism. ..
  57. Neural Basis of Semantic Constraints on Adjective Order
    David Kemmerer; Fiscal Year: 2006
    ..This will be done by recording event-related potentials in normal adults while they read examples of natural and unnatural adjective orders. [unreadable] [unreadable]..
  58. VESTIBULAR MECHANISMS IN THE DYNAMICS OF LOCOMOTION
    Theodore Raphan; Fiscal Year: 2006
    ....
  59. GLOBIN SWITCHING AND ERYTHROID DIFFERENTIATION
    Thalia Papayannopoulou; Fiscal Year: 2002
    ....
  60. TRAINING PROGRAM IN SYSTEMS NEUROSCIENCE
    David Amaral; Fiscal Year: 2002
    ..abstract_text> ..
  61. Multilevel Dynamics of Conditional Control Mechanisms
    Gin McCollum; Fiscal Year: 2006
    ....
  62. Studies on the Eppin family of proteins on chromosome 20
    MICHAEL G O apos RAND; Fiscal Year: 2010
    ..This aim will test the hypothesis that anti-Eppin antibodies disrupt Eppin's modulation of PSA activity. ..
  63. BEHAVIORAL EFFECTS AND ABUSE OF DOPAMINERGIC DRUGS
    Jack Bergman; Fiscal Year: 2007
    ..This research should point to novel directions for the development of medications with which to manage the abuse and addictive liabilities of psychomotor stimulant drugs ..
  64. Functional architecture of switching between two tasks
    Glenn Wylie; Fiscal Year: 2004
    ..Thus, our pilot data suggest that we have found two robust methods for investigating control processes, and it is the purpose of this proposal to use these paradigms to gain a better understanding of executive control. ..
  65. Reduction and Telemetry of Neural Data for an Implantable Data Acquisition System
    MICHAEL RIZK; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  66. MECHANISMS OF PERCEPTUAL ORGANIZATION IN HUMAN VISION
    Robert Blake; Fiscal Year: 2005
    ..In addition, the work on spatial structure from temporal synchrony may have implications for understanding clinical disorders involving disruptions in temporal processing, including dyslexia. ..
  67. COCHLEAR MECHANICS
    WILLIAM RHODE; Fiscal Year: 2007
    ..Mechanical measurements will be compared I to auditory nerve responses in the same species and using the same signals. ..
  68. Female sexuality: modulation by estrogen and androgen
    Kim Wallen; Fiscal Year: 2005
    ..These therapies will also be compared on their effects on neuroendocrine function. These studies will markedly increase our understanding of the role that ovarian steroids play in modulating women's sexuality. ..
  69. SOY, LIFE STAGE, STRESS AND ATHEROSCLEROSIS IN FEMALES
    JAY KAPLAN; Fiscal Year: 2009
    ....
  70. ARBOVIRUS PERSISTENCE IN SEASONAL WETLANDS
    William Reisen; Fiscal Year: 2002
    ..Virus ecology at wetlands in the Coachella Valley of southeastern California with consistent enzootic activity will be compared with wetlands in the southern San Joaquin Valley where virus activity currently is intermittent. ..