Top Publications

  1. pmc A molecular phylogeny of living primates
    Polina Perelman
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland, USA
    PLoS Genet 7:e1001342. 2011
  2. ncbi Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution
    Z Yang
    Department of Biology, University College, London, United Kingdom
    Mol Biol Evol 15:568-73. 1998
  3. pmc Maps and streams in the auditory cortex: nonhuman primates illuminate human speech processing
    Josef P Rauschecker
    Laboratory of Integrative Neuroscience and Cognition, Georgetown University Medical Center, Washington, DC, USA
    Nat Neurosci 12:718-24. 2009
  4. pmc Patterns of positive selection in six Mammalian genomes
    Carolin Kosiol
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 4:e1000144. 2008
  5. pmc Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates
    Antoine Molaro
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Cell 146:1029-41. 2011
  6. doi Advanced antisense therapies for postexposure protection against lethal filovirus infections
    Travis K Warren
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    Nat Med 16:991-4. 2010
  7. pmc BST-2/tetherin: a new component of the innate immune response to enveloped viruses
    David T Evans
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, One Pine Hill Drives, Southborough, MA 01772, USA
    Trends Microbiol 18:388-96. 2010
  8. pmc Neuron densities vary across and within cortical areas in primates
    Christine E Collins
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Proc Natl Acad Sci U S A 107:15927-32. 2010
  9. pmc Characterization of the fecal microbiome from non-human wild primates reveals species specific microbial communities
    Suleyman Yildirim
    The Institute for Genomic Biology, University of Illinois, Urbana, Illinois, United States of America
    PLoS ONE 5:e13963. 2010
  10. pmc Relaxed phylogenetics and dating with confidence
    Alexei J Drummond
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Biol 4:e88. 2006

Detail Information

Publications397 found, 100 shown here

  1. pmc A molecular phylogeny of living primates
    Polina Perelman
    Laboratory of Genomic Diversity, National Cancer Institute Frederick, Frederick, Maryland, USA
    PLoS Genet 7:e1001342. 2011
    Comparative genomic analyses of primates offer considerable potential to define and understand the processes that mold, shape, and transform the human genome...
  2. ncbi Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution
    Z Yang
    Department of Biology, University College, London, United Kingdom
    Mol Biol Evol 15:568-73. 1998
    ..The likelihood analysis thus confirmed most, but not all, conclusions Messier and Stewart reached using reconstructed ancestral sequences to estimate synonymous and nonsynonymous rates for different lineages...
  3. pmc Maps and streams in the auditory cortex: nonhuman primates illuminate human speech processing
    Josef P Rauschecker
    Laboratory of Integrative Neuroscience and Cognition, Georgetown University Medical Center, Washington, DC, USA
    Nat Neurosci 12:718-24. 2009
    ..A new model connects structures in the temporal, frontal and parietal lobes linking speech perception and production...
  4. pmc Patterns of positive selection in six Mammalian genomes
    Carolin Kosiol
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 4:e1000144. 2008
    ..This study provides additional evidence for widespread positive selection in mammalian evolution and new genome-wide insights into the functional implications of positive selection...
  5. pmc Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates
    Antoine Molaro
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Cell 146:1029-41. 2011
    ..Thus, the features that determine DNA methylation patterns differ between male germ cells and somatic cells, and elements of these features have diverged between humans and chimpanzees...
  6. doi Advanced antisense therapies for postexposure protection against lethal filovirus infections
    Travis K Warren
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    Nat Med 16:991-4. 2010
    ..PMOplus may be useful for treating these and other highly pathogenic viruses in humans...
  7. pmc BST-2/tetherin: a new component of the innate immune response to enveloped viruses
    David T Evans
    Department of Microbiology and Molecular Genetics, Harvard Medical School, New England Primate Research Center, One Pine Hill Drives, Southborough, MA 01772, USA
    Trends Microbiol 18:388-96. 2010
    ..Here, we review this new host-pathogen relationship and discuss its impact on the evolution of primate lentiviruses and the origins of the HIV pandemic...
  8. pmc Neuron densities vary across and within cortical areas in primates
    Christine E Collins
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Proc Natl Acad Sci U S A 107:15927-32. 2010
    ..In all primates examined, primary visual cortex (V1) was the most neuron-dense cortical area and the secondary visual areas had ..
  9. pmc Characterization of the fecal microbiome from non-human wild primates reveals species specific microbial communities
    Suleyman Yildirim
    The Institute for Genomic Biology, University of Illinois, Urbana, Illinois, United States of America
    PLoS ONE 5:e13963. 2010
    ..It has been hypothesized that the gastrointestinal microbiome of humans and other non-human primates may have played significant roles in host evolution by facilitating a range of dietary adaptations...
  10. pmc Relaxed phylogenetics and dating with confidence
    Alexei J Drummond
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Biol 4:e88. 2006
    ..From these we conclude that our method is phylogenetically more accurate and precise than the traditional unrooted model while adding the ability to infer a timescale to evolution...
  11. ncbi Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
    ..Here we show that human FOXP2 contains changes in amino-acid coding and a pattern of nucleotide polymorphism, which strongly suggest that this gene has been the target of selection during recent human evolution...
  12. ncbi Ancient co-speciation of simian foamy viruses and primates
    William M Switzer
    HIV and Retrovirology Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 19, Atlanta, Georgia 30333, USA
    Nature 434:376-80. 2005
    ..Simian foamy viruses (SFVs) are ubiquitous, non-pathogenic retroviruses that infect all primates. Here we test the co-speciation hypothesis in SFVs and their primate hosts by comparing the phylogenies of SFV ..
  13. pmc A mitogenomic phylogeny of living primates
    Knut Finstermeier
    Research Group Molecular Ecology, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS ONE 8:e69504. 2013
    b>Primates, the mammalian order including our own species, comprise 480 species in 78 genera. Thus, they represent the third largest of the 18 orders of eutherian mammals...
  14. pmc Loss of olfactory receptor genes coincides with the acquisition of full trichromatic vision in primates
    Yoav Gilad
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E5. 2004
    ..To investigate the process of degeneration of the olfactory repertoire in primates, we estimated the proportion of OR pseudogenes in 19 primate species by surveying randomly chosen subsets of 100 ..
  15. pmc Learning to control a brain-machine interface for reaching and grasping by primates
    Jose M Carmena
    Department of Neurobiology, Duke University, Durham, North Carolina, USA
    PLoS Biol 1:E42. 2003
    Reaching and grasping in primates depend on the coordination of neural activity in large frontoparietal ensembles...
  16. pmc Evolution of mammals and their gut microbes
    Ruth E Ley
    Center for Genome Sciences, Washington University School of Medicine, St Louis, MO 63108, USA
    Science 320:1647-51. 2008
    ..bacterial diversity, which increases from carnivory to omnivory to herbivory; that bacterial communities codiversified with their hosts; and that the gut microbiota of humans living a modern life-style is typical of omnivorous primates.
  17. pmc Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa
    Peter L Oliver
    Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 5:e1000753. 2009
    ..Similar patterns are apparent for Prdm9 zinc fingers for diverse metazoans, including primates. Indeed, allelic variation at the DNA-binding positions of human PRDM9 zinc fingers show significant association ..
  18. pmc Detection of nonneutral substitution rates on mammalian phylogenies
    Katherine S Pollard
    Gladstone Institutes, University of California, San Francisco, San Francisco, California 94158, USA
    Genome Res 20:110-21. 2010
    ..We also describe new "Conservation" tracks in the UCSC Genome Browser that display both phyloP and phastCons scores for genome-wide alignments of 44 vertebrate species...
  19. pmc Ancient adaptive evolution of tetherin shaped the functions of Vpu and Nef in human immunodeficiency virus and primate lentiviruses
    Efrem S Lim
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, P O Box 10924, Seattle, WA 98109 1024, USA
    J Virol 84:7124-34. 2010
    ..Human Tetherin is unique among the Tetherins of simian primates in that it has a 5-amino-acid deletion that results in the loss of the residue under the strongest positive ..
  20. doi The strange blood: natural hybridization in primates
    Dietmar Zinner
    Ceognitive Ethology Laboratory, German Primate Center, University of Gottingen, Germany
    Evol Anthropol 20:96-103. 2011
    ..In primates, hybridization has occurred mainly between subspecies and species, but has also been detected between genera and ..
  21. doi Degeneration of olfactory receptor gene repertories in primates: no direct link to full trichromatic vision
    Atsushi Matsui
    Department of Cellular and Molecular Biology, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan
    Mol Biol Evol 27:1192-200. 2010
    ..It is generally thought that primates are vision oriented and dependent weakly on olfaction...
  22. pmc Gene regulation in primates evolves under tissue-specific selection pressures
    Ran Blekhman
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 4:e1000271. 2008
    ..These observations are consistent with the notion that adaptive circumscribed changes in gene regulation have fewer deleterious pleiotropic effects compared with changes at the protein sequence level...
  23. pmc Macroevolutionary dynamics and historical biogeography of primate diversification inferred from a species supermatrix
    Mark S Springer
    Department of Biology, University of California Riverside, Riverside, California, United States of America
    PLoS ONE 7:e49521. 2012
    ..Relaxed clock analyses of divergence times with 14 fossil-calibrated nodes suggest that living Primates last shared a common ancestor 71-63 Ma, and that divergences within both Strepsirrhini and Haplorhini are ..
  24. doi Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates
    Stephen H Montgomery
    Department of Zoology, University of Cambridge, Cambridge, United Kingdom
    Mol Biol Evol 28:625-38. 2011
    ..with microcephaly (ASPM, CDK5RAP2, CENPJ, MCPH1) across 21 species representing all major clades of anthropoid primates. Contrary to prevailing assumptions, positive selection was not limited to or intensified along the lineage ..
  25. pmc Preclinical differences of intravascular AAV9 delivery to neurons and glia: a comparative study of adult mice and nonhuman primates
    Steven J Gray
    Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Mol Ther 19:1058-69. 2011
    ..When this approach was applied to juvenile nonhuman primates (NHPs) at the middle dose (9-9...
  26. pmc Estimating the phylogeny and divergence times of primates using a supermatrix approach
    Helen J Chatterjee
    Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK
    BMC Evol Biol 9:259. 2009
    The primates are among the most broadly studied mammalian orders, with the published literature containing extensive analyses of their behavior, physiology, genetics and ecology...
  27. ncbi Recombination drives the evolution of GC-content in the human genome
    Julien Meunier
    UMR 5558 CNRS, Université Lyon I, Villeurbanne, France
    Mol Biol Evol 21:984-90. 2004
    ..These results have important implications for understanding the spatial and temporal variations of substitution processes in a broad range of sexual organisms, and for detecting the hallmarks of natural selection in DNA sequences...
  28. pmc Dating primate divergences through an integrated analysis of palaeontological and molecular data
    Richard D Wilkinson
    School of Mathmatical Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Syst Biol 60:16-31. 2011
    ..To perform the inference, a new approximate Bayesian computation (ABC) algorithm is introduced, where the structure of the model can be exploited in an ABC-within-Gibbs algorithm to provide a more efficient analysis...
  29. pmc Evidence for a convergent slowdown in primate molecular rates and its implications for the timing of early primate evolution
    Michael E Steiper
    Department of Anthropology, Hunter College of the City University of New York, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:6006-11. 2012
    ..One explanation for this phenomenon is that crown primates existed in the Cretaceous but that their fossil remains have not yet been found...
  30. pmc Gene expression differences among primates are associated with changes in a histone epigenetic modification
    Carolyn E Cain
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 187:1225-34. 2011
    Changes in gene regulation are thought to play an important role in speciation and adaptation, especially in primates. However, we still know relatively little about the mechanisms underlying regulatory evolution...
  31. pmc Vesicular stomatitis virus-based ebola vaccine is well-tolerated and protects immunocompromised nonhuman primates
    Thomas W Geisbert
    National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, USA
    PLoS Pathog 4:e1000225. 2008
    ..progress has been made over the last decade in developing candidate preventive vaccines that can protect nonhuman primates against EBOV...
  32. doi Molecular evolution and network-level analysis of the N-glycosylation metabolic pathway across primates
    Ludovica Montanucci
    Department of Experimental and Health Sciences, Institute of Evolutionary Biology, Universitat Pompeu Fabra Consejo Superior de Investigaciones Cientificas, Barcelona, Catalonia, Spain
    Mol Biol Evol 28:813-23. 2011
    ..forces that shaped the evolution of the genes involved in the synthesis of the N-glycans during the divergence of primates within the framework of their functional network...
  33. pmc Convergent evolution of escape from hepaciviral antagonism in primates
    Maulik R Patel
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Biol 10:e1001282. 2012
    ..antagonism has shaped the evolution of the host protein MAVS--a crucial component of the viral-sensing pathway in primates. From sequencing and phylogenetic analyses of MAVS from 21 simian primates, we found that MAVS has evolved under ..
  34. pmc Comparative RNA sequencing reveals substantial genetic variation in endangered primates
    George H Perry
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 22:602-10. 2012
    Comparative genomic studies in primates have yielded important insights into the evolutionary forces that shape genetic diversity and revealed the likely genetic basis for certain species-specific adaptations...
  35. ncbi The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum
    D Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Neuroscience 96:451-74. 2000
    This Commentary compares the connections of the dopaminergic system with the striatum in rats and primates with respect to two levels of striatal organization: a tripartite functional (motor, associative and limbic) subdivision and a ..
  36. pmc Detecting positive selection within genomes: the problem of biased gene conversion
    Abhirami Ratnakumar
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, 751 23 Uppsala, Sweden
    Philos Trans R Soc Lond B Biol Sci 365:2571-80. 2010
    ..Our results indicate that gBGC significantly affects the evolution of coding sequences in primates, often leading to patterns of evolution that can be mistaken for positive selection.
  37. doi Trypanosoma cruzi in Brazilian Amazonia: Lineages TCI and TCIIa in wild primates, Rhodnius spp. and in humans with Chagas disease associated with oral transmission
    Arlei Marcili
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, 05508 900 Sao Paulo, SP, Brazil
    Int J Parasitol 39:615-23. 2009
    ..cruzi I (TCI) and T. cruzi IIa (TCIIa) circulate amongst non-human primates in Brazilian Amazonia, and are transmitted by Rhodnius species in overlapping arboreal transmission cycles, ..
  38. pmc Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates
    Tarique D Perera
    Department of Psychiatry, College of Physicians and Surgeons, Columbia University Medical Center and New York State Psychiatric Institute, New York, New York, United States of America
    PLoS ONE 6:e17600. 2011
    ..Pen-3 subjects 2 weeks of irradiation (N = 4) or sham-irradiation (N = 2) and then exposed to 15 weeks of stress and fluoxetine. Dependent measures were weekly behavioral observations and postmortem neurogenesis levels...
  39. ncbi RNAi-mediated gene silencing in non-human primates
    Tracy S Zimmermann
    Alnylam Pharmaceuticals Inc, 300 Third Street, Cambridge, Massachusetts 02142, USA
    Nature 441:111-4. 2006
    ..systemically in a liposomal formulation, can silence the disease target apolipoprotein B (ApoB) in non-human primates. APOB-specific siRNAs were encapsulated in stable nucleic acid lipid particles (SNALP) and administered by ..
  40. ncbi Primates--a natural heritage of conflict resolution
    F B de Waal
    Living Links, Center for the Advanced Study of Human and Ape Evolution, Yerkes Regional Primate Research Center, and Psychology Department, Emory University, Atlanta, GA 30322, USA
    Science 289:586-90. 2000
    ..For example, chimpanzees kiss and embrace after fights, and other nonhuman primates engage in similar "reconciliations...
  41. doi Patterns of macroevolution among Primates inferred from a supermatrix of mitochondrial and nuclear DNA
    P H Fabre
    Institut des Sciences de l Evolution ISEM, UMR 5554 CNRS, Universite Montpellier II, Place E Bataillon, CC 064, 34095 Montpellier Cedex 5, France
    Mol Phylogenet Evol 53:808-25. 2009
    ..The resulting dated tree allowed to infer of macroevolutionary processes among the primates. Shifts in diversification rate and speciation rates were determined using the SymmeTREE method and a birthdeath ..
  42. ncbi Molecular evolution of trichromacy in primates
    D M Hunt
    Department of Molecular Genetics, Institute of Ophthalmology, University College London, UK
    Vision Res 38:3299-306. 1998
    Although trichromacy in Old and New World primates is based on three visual pigments with spectral peaks in the violet (SW, shortwave), green (MW, middlewave) and yellow-green (LW, longwave) regions of the spectrum, the underlying genetic ..
  43. doi New Oligocene primate from Saudi Arabia and the divergence of apes and Old World monkeys
    Iyad S Zalmout
    Museum of Paleontology, University of Michigan, 1109 Geddes Avenue, Ann Arbor, Michigan 48109, USA
    Nature 466:360-4. 2010
    ..Saadanius has a tubular ectotympanic but lacks synapomorphies of either group of crown Catarrhini, and we infer that the hominoid-cercopithecoid split happened later, between 29-28 and 24 Myr ago...
  44. doi Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates
    A Moreau
    INSERM U643, CHU Hotel Dieu, Nantes, France
    FASEB J 23:3070-7. 2009
    Clinical translation of dendritic cell (DC)-based cell therapy requires preclinical studies in nonhuman primates (NHPs)...
  45. ncbi A model for tool-use traditions in primates: implications for the coevolution of culture and cognition
    Carel P van Schaik
    Department of Biological Anthropology and Anatomy, Duke University, Box 90383, Durham, NC 27708 0383, USA
    J Hum Evol 44:645-64. 2003
    ..or cultures), we developed a formal model to predict the incidence of these acquired specializations among wild primates and to examine the evolution of their underlying abilities...
  46. doi New insulin-like growth factor (IGF)-precursor sequences from mammalian genomes: the molecular evolution of IGFs and associated peptides in primates
    Michael Wallis
    Biochemistry Department, School of Life Sciences, University of Sussex, Falmer, Brighton, Sussex, UK
    Growth Horm IGF Res 19:12-23. 2009
    ..IGF precursors from several new species, and this has been used here to study the evolution of these proteins in primates. The sequence of insulin is strongly conserved in primates except for the branch leading to NWM - the sequence of ..
  47. pmc An optogenetic toolbox designed for primates
    Ilka Diester
    Department of Bioengineering, Stanford University, Stanford, California, USA
    Nat Neurosci 14:387-97. 2011
    ..We present a set of optogenetic tools designed for optogenetic experiments in the non-human primate brain...
  48. pmc Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates
    Patricia A Lawlor
    Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
    Mol Ther 17:1692-702. 2009
  49. pmc Novel adenoviruses in wild primates: a high level of genetic diversity and evidence of zoonotic transmissions
    Diana Wevers
    Division of Viral Infections, Robert Koch Institute, Berlin, Germany
    J Virol 85:10774-84. 2011
    Adenoviruses (AdVs) broadly infect vertebrate hosts, including a variety of nonhuman primates (NHPs)...
  50. doi Stepwise evolution of stable sociality in primates
    Susanne Shultz
    Institute of Cognitive and Evolutionary Anthropology, 64 Banbury Road, University of Oxford, Oxford OX2 6PN, UK
    Nature 479:219-22. 2011
    ..much attention has been focused on explaining and describing the diversity of social grouping patterns among primates, less effort has been devoted to understanding the evolutionary history of social living...
  51. pmc Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates
    Adrian F Gombart
    Linus Pauling Institute, Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon, USA
    BMC Genomics 10:321. 2009 additional primate lineages would provide strong evidence that the TLR2/1-vitamin D-cathelicidin pathway evolved as a biologically important immune response mechanism protecting human and non-human primates against infection.
  52. pmc A comparative MRI study of the relationship between neuroanatomical asymmetry and interhemispheric connectivity in primates: implication for the evolution of functional asymmetries
    W D Hopkins
    Department of Psychology, Berry College, USA
    Behav Neurosci 114:739-48. 2000
    ..of corpus callosum size to brain volume (CC:VOL) and to neocortical surface area (CC:NEO) in human and nonhuman primates. Magnetic resonance images were collected in a sample of 45 primates including 8 New World monkeys, 10 Old World ..
  53. ncbi Prefrontal white matter volume is disproportionately larger in humans than in other primates
    P Thomas Schoenemann
    Department of Anthropology, University of Pennsylvania, 3260 South St, Philadelphia, Pennsylvania 19104 6398, USA
    Nat Neurosci 8:242-52. 2005
    ..This suggests that connectional elaboration (as gauged by white matter volume) played a key role in human brain evolution...
  54. pmc Single-injection vaccine protects nonhuman primates against infection with marburg virus and three species of ebola virus
    Thomas W Geisbert
    Department of Microbiology, National Emerging Infectious Diseases Laboratories Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Virol 83:7296-304. 2009
    ..Marburg virus and Ebola virus cause severe hemorrhagic fever with high mortality in humans and nonhuman primates. Among the most promising filovirus vaccines under development is a system based on recombinant vesicular ..
  55. ncbi Long-term effects of early-life environmental manipulations in rodents and primates: Potential animal models in depression research
    Christopher R Pryce
    Behavioural Neurobiology Laboratory, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Zurich, Switzerland
    Neurosci Biobehav Rev 29:649-74. 2005
    ..Studies of postnatal environmental manipulations in rodents and primates can potentially yield evidence that abnormal early-life experience leading to dysfunction of the neurobiology, ..
  56. pmc Manganese neurotoxicity: lessons learned from longitudinal studies in nonhuman primates
    Neal C Burton
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Health Perspect 117:325-32. 2009
    ..The comparatively sparse studies incorporating in vivo neuroimaging in nonhuman primates provide invaluable insights on the effects of Mn on brain chemistry.
  57. ncbi Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses
    Steven M Jones
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    Nat Med 11:786-90. 2005
    ..intramuscular injection of the EBOV or MARV vaccine elicited completely protective immune responses in nonhuman primates against lethal EBOV or MARV challenges...
  58. ncbi Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates
    J E Steiner
    Department of Oral Biology, The Hebrew University, Jerusalem, Israel
    Neurosci Biobehav Rev 25:53-74. 2001
    ..affective reactions elicited by tastes from eight newborn human infants, and from 27 other infant or adult primates. Non-human primates belonged to 11 species: three great apes (chimpanzee, orangutan, gorilla), three Old World ..
  59. ncbi Origins of HIV and the evolution of resistance to AIDS
    Jonathan L Heeney
    Department of Virology, Biomedical Primate Research Centre, Rijswijk 2280 GH, Netherlands
    Science 313:462-6. 2006
    The cross-species transmission of lentiviruses from African primates to humans has selected viral adaptations which have subsequently facilitated human-to-human transmission...
  60. pmc Social intelligence, innovation, and enhanced brain size in primates
    Simon M Reader
    Department of Zoology, University of Cambridge, High Street, Madingley, Cambridge CB3 8AA, United Kingdom
    Proc Natl Acad Sci U S A 99:4436-41. 2002
    ..The ability to learn from others, invent new behaviors, and use tools may have played pivotal roles in primate brain evolution...
  61. pmc Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates
    Hideyuki Tanabe
    Department of Biology II Human Genetics, University of Munich, Richard Wagner Strasse 10, 80333 München, Germany
    Proc Natl Acad Sci U S A 99:4424-9. 2002
    ..The evolutionarily conserved positioning of homologous chromosomes or chromosome segments in related species supports evidence for a functionally relevant higher-order chromatin arrangement that is correlated with gene-density...
  62. pmc Adaptation and constraint at Toll-like receptors in primates
    Gabriela Wlasiuk
    Department of Ecology and Evolutionary Biology, University of Arizona, AZ, USA
    Mol Biol Evol 27:2172-86. 2010
    ..We found a clear signature of positive selection in the rates of substitution across primates in most TLRs...
  63. pmc Molecular evolution and tempo of amplification of human LINE-1 retrotransposons since the origin of primates
    Hameed Khan
    Department of Biology, Queens College, The City University of New York, Flushing, New York 11367, USA
    Genome Res 16:78-87. 2006
    ..of the families of LINE-1 (L1) retrotransposons that have amplified in the human lineage since the origin of primates. We identified two phases in the evolution of L1...
  64. pmc Comparative analysis of Alu repeats in primate genomes
    George E Liu
    USDA, ARS, ANRI, Bovine Functional Genomics Laboratory, Beltsville, MD 20705, USA
    Genome Res 19:876-85. 2009
    ..a global assessment of the divergence distributions, phylogenies, and consensus sequences for Alu elements in primates including lemur, marmoset, macaque, baboon, and chimpanzee as compared to human...
  65. ncbi Does the mastery of center-embedded linguistic structures distinguish humans from nonhuman primates?
    Pierre Perruchet
    University of Bourgogne, Dijon, France
    Psychon Bull Rev 12:307-13. 2005
    ..that, beyond the specific drawbacks inherent in F&H's study, researching the source of the inability of nonhuman primates to master language within a framework built around Chomsky's hierarchy of grammars is a conceptual dead end.
  66. pmc The evolution of primate general and cultural intelligence
    Simon M Reader
    Department of Biology and Helmholtz Institute, Utrecht University, Utrecht, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 366:1017-27. 2011
    ..correlated composite of cognitive traits suggests social, technical and ecological abilities have coevolved in primates, indicative of an across-species general intelligence that includes elements of cultural intelligence...
  67. pmc Adenosine-to-inosine RNA editing shapes transcriptome diversity in primates
    Nurit Paz-Yaacov
    Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Proc Natl Acad Sci U S A 107:12174-9. 2010
    ..due to exceptional editing within the primate-specific Alu sequences, but the global editing level of nonhuman primates has not been studied so far...
  68. doi Personality in nonhuman primates: a review and evaluation of past research
    Hani D Freeman
    Department of Psychology, University of Texas at Austin, 78712, USA
    Am J Primatol 72:653-71. 2010
    Scientific reports of personality in nonhuman primates are now appearing with increasing frequency across a wide range of disciplines, including psychology, anthropology, endocrinology, and zoo management...
  69. ncbi Using the fossil record to estimate the age of the last common ancestor of extant primates
    Simon Tavare
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 1340, USA
    Nature 416:726-9. 2002
    ..For the order Primates, molecular data calibrated with various external fossil dates uniformly suggest a mid-Cretaceous divergence from ..
  70. doi Origin of primate orphan genes: a comparative genomics approach
    Macarena Toll-Riera
    Evolutionary Genomics Group, Biomedical Informatics Research Programme, Fundació Institut Municipal d Investigació Mèdica, Barcelona, Spain
    Mol Biol Evol 26:603-12. 2009
    ..This indicates frequent recruitment of TEs as part of novel genes. Finally, we also obtain evidence that a small fraction of primate orphan genes, around 5.5%, might have originated de novo from mammalian noncoding genomic regions...
  71. ncbi Neurobiological mechanisms of the onset of puberty in primates
    E Terasawa
    Department of Pediatrics, Wisconsin Regional Primate Research Center, and University of Wisconsin Madison, 53715 1299, USA
    Endocr Rev 22:111-51. 2001
    ..However, the mechanism controlling the pubertal increase in LHRH release is still unclear. In primates the LHRH neurosecretory system is already active during the neonatal period but subsequently enters a dormant ..
  72. doi MicroRNA silencing in primates: towards development of novel therapeutics
    Andreas Petri
    Santaris Pharma, Kogle Alle 6, Hørsholm, Denmark and Wilhelm Johannsen Centre for Functional Genome Research, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, Copenhagen, Denmark
    Cancer Res 69:393-5. 2009
    ..Recent reports on efficient miRNA silencing in rodents and nonhuman primates using high-affinity targeting by chemically modified antisense oligonucleotides highlight the utility of such ..
  73. ncbi Brains, innovations and evolution in birds and primates
    Louis Lefebvre
    Department of Biology, McGill University, Montreal, Quec, Canada
    Brain Behav Evol 63:233-46. 2004
    ..In both birds and primates, innovation rate is positively correlated with the relative size of association areas in the brain, the ..
  74. pmc Calorie restriction and aging in nonhuman primates
    Joseph W Kemnitz
    Wisconsin National Primate Research Center, 1220 Capitol Court, Madison, WI 53715 1299, USA
    ILAR J 52:66-77. 2011
    ..This research offers tremendous potential for producing novel insights into aging and risk of disease...
  75. ncbi Nonhuman primates prefer slow tempos but dislike music overall
    Josh McDermott
    Department of Brain and Cognitive Sciences, MIT, Perceptual Science Group, Cambridge, MA 02139, USA
    Cognition 104:654-68. 2007
    ..Cognition, 94(2), B11-B21] to test cotton-top tamarins and common marmosets, two new-World primates, for their spontaneous responses to stimuli that varied systematically with respect to tempo...
  76. ncbi Codon-substitution models for detecting molecular adaptation at individual sites along specific lineages
    Ziheng Yang
    Galton Laboratory, Department of Biology, University College London
    Mol Biol Evol 19:908-17. 2002
    ..models as well as previous branch- and site-specific models to three data sets: the lysozyme genes from primates, the tumor suppressor BRCA1 genes from primates, and the phytochrome (PHY) gene family in angiosperms...
  77. ncbi Comparative primate genomics
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Annu Rev Genomics Hum Genet 5:351-78. 2004
    ..the advent of technologies to study functional aspects of genomes, molecular comparisons between humans and other primates have gained momentum...
  78. pmc Noninvasive, transient and selective blood-brain barrier opening in non-human primates in vivo
    Fabrice Marquet
    Department of Biomedical Engineering, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e22598. 2011
    ..For the first time, the feasibility of transcranial ME-FUS BBB opening in non-human primates is demonstrated with subsequent BBB recovery...
  79. ncbi Mitochondrial DNA sequences of primates: tempo and mode of evolution
    W M Brown
    J Mol Evol 18:225-39. 1982
    ..bp in length, contains the genes for three transfer RNAs and parts of two proteins, and is homologous in all 5 primates. The 5 sequences differ from one another by base substitutions at 283 positions and by a deletion of one base ..
  80. ncbi Displacement activities as a behavioral measure of stress in nonhuman primates and human subjects
    Alfonso Troisi
    Department of Psychiatry, University of Rome Tor Vergata, via Guattani, 14, 00161 Rome, Italy
    Stress 5:47-54. 2002
    ..of stress is to analyze those behavior patterns that ethologists have named displacement activities and that, in primates, consist mostly of self-directed behaviors...
  81. pmc Dissecting the role of dendritic cells in simian immunodeficiency virus infection and AIDS
    Elizabeth R Wonderlich
    Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA, USA
    Immunol Res 50:228-34. 2011
    ..Both DC subsets have been well characterized in nonhuman primates and shown to have strikingly similar phenotypic and functional characteristics to their counterparts in the human...
  82. pmc On the immortality of television sets: "function" in the human genome according to the evolution-free gospel of ENCODE
    Dan Graur
    Department of Biology and Biochemistry, University of Houston, TX, USA
    Genome Biol Evol 5:578-90. 2013
    ..The ENCODE results were predicted by one of its authors to necessitate the rewriting of textbooks. We agree, many textbooks dealing with marketing, mass-media hype, and public relations may well have to be rewritten...
  83. pmc Transmission characteristics of primate vocalizations: implications for acoustic analyses
    Peter Maciej
    Cognitive Ethology Laboratory, German Primate Center, Gottingen, Germany
    PLoS ONE 6:e23015. 2011
    ..Because the recording conditions can have appreciable effects on acoustic parameters, it is advisable to validate the extraction method of acoustic variables from recordings over longer distances before using them in acoustic analyses...
  84. pmc Is group size related to longevity in mammals?
    Jason M Kamilar
    Department of Anthropology, Yale University, New Haven, CT 06520, USA
    Biol Lett 6:736-9. 2010
    ..We found that group size was a poor predictor of maximum longevity across all mammals, as well as within primates and rodents...
  85. pmc Frequent gene conversion events between the X and Y homologous chromosomal regions in primates
    Mineyo Iwase
    The Center for the Promotion of Integrated Sciences, The Graduate University for Advanced Studies Sokendai, Shonan Village, Hayama, Kanagawa 240 0193, Japan
    BMC Evol Biol 10:225. 2010
    ..To examine the evolutionary mechanism for this low p-distance region, sequences of a corresponding region including KALX/Y from seven species of non-human primates were analyzed.
  86. pmc Novel multiplexed HIV/simian immunodeficiency virus antibody detection assay
    Steve Ahuka-Mundeke
    University of Montpellier, Montpellier, France
    Emerg Infect Dis 17:2277-86. 2011
    ..To assess the risk for cross-species transmission of simian immunodeficiency viruses (SIVs) from nonhuman primates to humans in the Democratic Republic of Congo, we collected 330 samples derived from nonhuman primate bushmeat at ..
  87. pmc Positive selection of primate TRIM5alpha identifies a critical species-specific retroviral restriction domain
    Sara L Sawyer
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 102:2832-7. 2005
    ..Our study highlights the power of evolutionary analyses, in which positive selection identifies not only the age of genetic conflict but also the interaction interface where this conflict plays out...
  88. pmc Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates
    Hemraj B Dodiya
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mol Ther 18:579-87. 2010
    ..The current data suggest that AAV2/5 and AAV2/1 are superior to AAV2/8 for gene delivery to the nonhuman primate striatum and therefore better candidates for therapeutic applications targeting this structure...
  89. ncbi Evolution of eye size and shape in primates
    Callum F Ross
    Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    J Hum Evol 52:294-313. 2007
    Strepsirrhine and haplorhine primates exhibit highly derived features of the visual system that distinguish them from most other mammals...
  90. pmc Emergence of young human genes after a burst of retroposition in primates
    Ana Claudia Marques
    Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    PLoS Biol 3:e357. 2005
    ..retrogenes on the lineage leading to humans generated by the high rate of retroposition (retroduplication) in primates. Extensive comparative sequencing and expression studies coupled with evolutionary analyses and simulations ..
  91. ncbi Phylogenetic analyses of dimorphism in primates: evidence for stronger selection on canine size than on body size
    Sandra Thorén
    Department of Zoology, Stockholm University, 10691 Stockholm, Sweden
    Am J Phys Anthropol 130:50-9. 2006
    ..methods were used to analyze the consequences of sexual selection on canine size and canine size dimorphism in primates. Our analyses of previously published body mass and canine size data revealed that the degree of sexual selection ..
  92. pmc Coevolution of vocal communication and sociality in primates
    Karen McComb
    Department of Psychology, School of Life Sciences, University of Sussex, Brighton BN1 9QG, UK
    Biol Lett 1:381-5. 2005
  93. pmc Evolution of the mammalian placenta revealed by phylogenetic analysis
    Derek E Wildman
    Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:3203-8. 2006
    ..Here we challenge the view that the hemochorial placenta is a derived feature in haplorhine primates. Using phylogenetic and statistical analyses of molecular and morphological data, we demonstrate that the ..
  94. doi Simian foamy virus infection in humans: prevalence and management
    Arifa S Khan
    Laboratory of Retrovirus Research, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, 8800 Rockville Pike, Bethesda, MD 20892, USA
    Expert Rev Anti Infect Ther 7:569-80. 2009
    ..These steps will help prevent the emergence of a novel pathogen and reduce the risk of transmission of another potential pathogenic human retrovirus...
  95. doi Convergent evolution of anthropoid-like adaptations in Eocene adapiform primates
    Erik R Seiffert
    Department of Anatomical Sciences, Stony Brook University, Stony Brook, New York 11794 8081, USA
    Nature 461:1118-21. 2009
    Adapiform or 'adapoid' primates first appear in the fossil record in the earliest Eocene epoch ( approximately 55 million years (Myr) ago), and were common components of Palaeogene primate communities in Europe, Asia and North America...
  96. ncbi Ecological importance of trichromatic vision to primates
    N J Dominy
    Department of Anatomy, University of Hong Kong, People s Republic of China
    Nature 410:363-6. 2001
    ..430 nm, approximately 535 nm and approximately 562 nm (refs 1, 2), has evolved convergently in catarrhine primates and one genus of New World monkey, the howlers (genus Alouatta)...
  97. pmc Social network analysis in the study of nonhuman primates: a historical perspective
    Lauren J N Brent
    Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA
    Am J Primatol 73:720-30. 2011
    ..these questions by providing an overview of the historical relationship between SNA and the study of nonhuman primates. We begin with a brief history of the development of SNA, followed by a detailed description of the network-based ..
  98. ncbi Osteological evidence for the evolution of activity pattern and visual acuity in primates
    R F Kay
    Department of Biological Anthropology and Anatomy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Phys Anthropol 113:235-62. 2000
    Examination of orbit size and optic foramen size in living primates reveals two adaptive phenomena. First, as noted by many authors, orbit size is strongly correlated with activity pattern...
  99. pmc On the genetic architecture of cortical folding and brain volume in primates
    Jeffrey Rogers
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 N W Loop 410, San Antonio, TX 78227, USA
    Neuroimage 53:1103-8. 2010
    ..The human brain is exceptional among primates in both total volume and gyrification, and therefore understanding the genetic mechanisms influencing variation ..
  100. pmc Molecular evolution of the primate antiviral restriction factor tetherin
    Jun Liu
    Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, China
    PLoS ONE 5:e11904. 2010
    ..Here, we performed a detailed evolutionary analysis to address this presumption...
  101. ncbi Genomic characterization of TT viruses (TTVs) in pigs, cats and dogs and their relatedness with species-specific TTVs in primates and tupaias
    Hiroaki Okamoto
    Immunology Division and Division of Molecular Virology, Jichi Medical School, Tochigi Ken 329 0498, Japan
    J Gen Virol 83:1291-7. 2002
    ..4-3.9 kb and TTV-like mini viruses (TLMVs) of 2.8-3.0 kb isolated from humans and non-human primates as well as tupaia TTVs of 2...

Research Grants70

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..hummingbirds, and songbirds) [unreadable] with the vast majority of species that do not have it - non-human primates, rodents, suboscine songbirds, pigeons, chickens, etc.1,2...
  2. Xenoestrogen regulation of Leydig cells
    ..Several reports in the literature have shown that exposure of rodents and non human primates to soy isoflavones affect testicular androgen secretion...
  3. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2010 monkypox-infected cynomolgus monkeys, which if successful, will require further testing in smallpox-infected primates, and will be done in collaboration with Dr. John Huggins, USAMRIID...
  4. Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C Family
    John S Adams; Fiscal Year: 2013
    ..years ago we began to investigate an outbreak of rachitic bone disease in adolescent, female New World primates residing at the Los Angles Zoo...
  5. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..CBLB502 is effective and non-toxic in mice and non-human primates and is being developed into a stable, self-administrable radiation antidote projected for biodefense applications...
  6. Systemic Inflammation and Central Nervous System Dysfunction
    Laura L Dugan; Fiscal Year: 2013
    ..Loss of these neurons is observed in rodents, dogs, and primates, and has been proposed to underlie cognitive deficits across cognitive domains...
  7. Novel DNA-Launched Attenuated Vaccine for VEE Virus
    PETER M PUSHKO; Fiscal Year: 2012
    ..with the optimal safety and immunogenicity profiles for future evaluation and challenge experiments in non-human primates. Our preliminary results suggest that the rational vaccine design and i-DNA technology can provide a ..
  8. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..aromatic hydrocarbons, have been associated with development or exacerbation of atherosclerosis in rodents and primates. Of relevance are the biological effects of benzo(a)pyrene (BaP), a carcinogen present in various forms of ..
  9. Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
    Anders M Naar; Fiscal Year: 2010
    ..One miRNA, miR-122, was shown in recent studies to modulate cholesterol levels in mice and non-human primates. These studies have highlighted the critical role played by miRNAs in mammalian physiology with relevance to ..
  10. Neuroimaging Assessments of Brain Integrity in Aging Mice
    Ai Ling Lin; Fiscal Year: 2013 identified;and, 3) these multi-metric imaging methods can be translated seamlessly from rodents to non-human primates and to humans...
  11. Epigenetic Analysis of iPS Cell Models of Aging and Alzheimer's Disease
    Bruce A Yankner; Fiscal Year: 2010
    ..particularly synaptic genes, is a prominent feature of human brain aging that has evolved in long-lived primates (1, 2)...
  12. Maternal nutrient restriction and nonhuman primate fetal skeletal muscle developm
    Min Du; Fiscal Year: 2010
    ..To date, work in this area has been exclusively in rats and sheep. Pregnancy studies using nonhuman primates (NHP) are vital to determine relevance of rat and sheep findings and permit extrapolation to human pregnancy...
  13. A Computational Framework for Mapping Long Range Genetic Circuits
    Tolga Tasdizen; Fiscal Year: 2010
    ..and for bridging the gap between axon projections and high resolution tracts obtained by MRI and DTI of non-human primates and humans...
  14. Beta Cell Adaptation to Stress in Baboon Pancreas After Partial Pancreatectomy
    FRANCO BATTISTA FOLLI; Fiscal Year: 2010
    ..Non human primates (NHPs) represent ideal models to study the role of amyloidogenic peptides in [unreadable]-cell decompensation, ..
  15. Developing miRNA diagnostic methods and identifying tumor regulatory networks
    Thomas Tuschl; Fiscal Year: 2010
    ..2005) and non-human primates (Elmen et al., 2008) have demonstrated the feasibility of manipulating miRNA levels...
  16. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..It is also active in primates in the conflict paradigm with no signs of muscle relaxation, or ataxia or sedation...
  17. Role of endothelin receptors in glaucomatous optic neuropathy
    Raghu R Krishnamoorthy; Fiscal Year: 2013
    ..of small doses of ET-1 to the retrobulbar region of the optic nerve has been shown to produce optic neuropathy in primates. However, the mechanism by which ET-1 produces these deleterious effects are not understood...
  18. RNA interference therapy for Huntington's disease: studies in non-human primates
    Beverly L Davidson; Fiscal Year: 2010
    ..This work is a collaborative effort between laboratories at the University of Iowa and the Oregon National Primate Research Center at the Oregon Health Sciences University. ..
  19. Long-Acting G-CSF Analog for Treating ARS
    GEORGE NORBERT COX; Fiscal Year: 2013
    ..Second, we will determine whether the protein improves survival of lethally-irradiated non-human primates, which is the gold standard ARS model adopted by the FDA...
  20. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..The overall aim of this proposal is to examine the interacting impact of adrenal and ovarian aging on the CNS of primates. Using the female rhesus macaque as a pragmatic animal model, we propose to test the hypothesis that the aging-..
  21. Macrophage-based Human Gene Therapy for Hereditary PAP
    Bruce C Trapnell; Fiscal Year: 2012
    ..and surfactant catabolism in macrophages from children with hPAP, evaluated in vivo in the lungs of non-human primates. A novel approach avoiding known impediments to lung gene therapy will take advantage of the natural survival ..
  22. Development of a Recombinant Tetravalent Dengue Vaccine Based on a Subunit Envelo
    Lynda G Tussey; Fiscal Year: 2013
    ..2x as the lead format for use in a tetravalent vaccine candidate in mice and non-human primates (NHP)...
  23. Optimal Selective Thyroid Hormone Analogs for Metabolic Syndrome
    John D Baxter; Fiscal Year: 2010
    ..reverse dyslipidemias, promote reverse cholesterol transport, reduce body fat in rodent models of obesity and primates, reduce liver fat in rodent models of non-alcoholic hepatic steatosis and improve insulin sensitivity in diabetic ..
  24. Steroid Regulation of Serotonin in Males
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2013
    ..However, knowledge of the steroid receptor profile in serotonin neurons of male human and nonhuman primates is lacking and little is known of the actions of androgens on gene expression in serotonin neurons...
  25. Food(cassava) cyanogen exposure and motor neuron degeneration
    ..OCN induces myeloneuropathy in primates through mechanisms that are not understood but possibly associated with protein misfolding...
  26. Neuroendocrine Response to Gastric Bypass in Nonhuman Primates
    Randy J Seeley; Fiscal Year: 2010
    ..For such studies, examination of nonhuman primates (NHPs) provides an attractive alternative...
  27. Genomics of RNA Editing: Identification and Regulation
    Jin Billy Li; Fiscal Year: 2013
    ..We will use this approach to extend our analysis to RNA editing in other primates such as chimpanzees and rhesus macaque monkeys, with the expectation of uncovering the contributions of RNA ..
  28. Effect of bisphenol A exposure on mammary stem cell function and transformation
    Luzhe Sun; Fiscal Year: 2013
    ..also use common marmoset to determine the effect of BPA on its MaSC function and transformation because nonhuman primates, with their close phylogenetic relationship to humans, can better simulate the effects of physiological and ..
  29. Neural Representation of Reach-to-Grasp for Cortical FES Neuroprostheses
    Abidemi Bolu Ajiboye; Fiscal Year: 2012
    ..The role of the brain in controlling arm and hand movements has been extensively studied in able-bodied non-human primates, but less so in humans with prolonged and severe paralysis...
  30. Gene Therapy for Retinitis Pigmentosa
    Rajendra Kumar-Singh; Fiscal Year: 2012
    ..adenovirus vectors (Hd-Ad) that have a 36K cloning capacity and persist episomally for years in non human primates. However, Hd-Ad vectors do not have a tropism for photoreceptors but instead, they target only the RPE...
  31. Novel Bacillus subtilis based spore vaccine to tuberculosis
    Subramanian Dhandayuthapani; Fiscal Year: 2013
    ..Ag85B and ESAT- 6, when used together, can elicit protective immune responses in mice, guinea pigs and nonhuman primates. This vaccine provides efficacy equivalent to that of BCG, so there is a potential for this to be a prophylactic ..
  32. Experimental Molecular Vaccines for Schistosomiasis
    Afzal A Siddiqui; Fiscal Year: 2012 an attempt to resolve a chronic parasitic infection and associated disease sequelae in mice and non-human primates. The development of schistosome-baboon chronic infection model may result in an important international resource ..
  33. Functional significance of Siglec-6, a novel leptin receptor, in human placental
    Virginia Winn; Fiscal Year: 2013
    ..While the B lymphocytes of all studied primates express Siglec-6, only human placenta expresses Siglec-6, which is intriguing given PE is a human-specific ..
  34. Regional Biocontainment Laboratory
    Charles Bailey; Fiscal Year: 2007
    ..with supporting animal research laboratories, aerobiology suites, a vivarium for small animals andnon- human primates, necropsy room, and associated support spaces...
  35. Determining Molecular Mechanisms of Chikungunya Virulence and Attenuation
    KATHERINE D RYMAN; Fiscal Year: 2010
    ..Chikungunya virus (CHIKV) is an arbovirus, transmitted between human and non-human primates by the bite of an infected mosquito vector...
  36. Adipose Stem Cell Therapy for Krabbe Disease
    Bruce Bunnell; Fiscal Year: 2009
    ..Additionally, the analysis of therapies in nonhuman primates permits the testing to be performed in a manner nearly identical to a human clinical trial...
    Richard L Stouffer; Fiscal Year: 2013
    ..synthesized steroids, regulates the structure-function of the peri-ovulatory follicle or corpus luteum (CL) in primates during the menstrual cycle...
  38. 18F-beta-Endorphin Imaging: Translational Study of an Opioid Peptide Radiotracer
    BRIAN contact REED; Fiscal Year: 2010
    ..of the co-PIs in peptide chemistry, analytical chemistry, and in vivo opioid receptor pharmacology in non-human primates, as well as guidance and collaboration in radiochemical synthesis, PET imaging, and its analysis...
  39. Tomotherapy and Hematopoietic Stem Cells For Tolerance to Kidney Transplants
    Samuel Strober; Fiscal Year: 2013
    ..can be effectively and safely achieved by establishing a stable immune mixed chimeric state in non-human primates using a novel non-myeloablative, helical tomotherapy-based total lymphoid irradiation (TLI) conditioning regimen ..
  40. Advancing a Lead Candidate Hantavirus Pulmonary Syndrome DNA Vaccine
    JAY WILLIAMS HOOPER; Fiscal Year: 2013
    ..vaccine delivered using the PharmaJet needle-free device for immunogenicity (neutralizing antibodies) in nonhuman primates, 2) manufacture HPS DNA vaccine plasmids as cGMP DNA, 3) conduct GLP preclinical toxicology testing of the HPS ..
  41. Treatment of Acute Coronary Syndromes with Recombinant LCAT Infusion
    BRIAN ROBERT KRAUSE; Fiscal Year: 2011
    ..will induce rapid changes in atherosclerotic lesions in rabbits, 3) to conduct a toxicology study in non-human primates to obtain the data for an Investigational New Drug submission;4) to demonstrate that rhLCAT becomes associated ..
  42. Case-Cohort Study of Cancers in Excess in Poultry Workers
    Eric S Johnson; Fiscal Year: 2013 vitro and transform them into cancerous cells, and experimentally the viruses can infect and cause tumors in primates. Furthermore, serological tests in humans clearly indicate widespread infection of the general population with ..
  43. Role of innate immune responses in the activity of an Alphavirus based adjuvant.
    Robert E Johnston; Fiscal Year: 2013
    ..This adjuvant effect was observed in four different mouse strains as well as in non-human primates. In macaques the adjuvant amplified the response to an off-the-shelf vaccine for seasonal influenza by over ..
  44. Attenuation of androgen deprivation therapy-induced metabolic syndrome by diet
    Oleg Varlamov; Fiscal Year: 2013
    ..the ADT-related MS and establish the effects of dietary fats on the progression and reversal of MS in non-human primates (NHP;rhesus macaques)...
    PAUL STEVEN BERNSTEIN; Fiscal Year: 2013
    ..No other mammals besides humans and fellow primates are known to take up carotenoids into ocular tissues at more than trace amounts...
  46. Phylogenomics and functional diversification of the Heterochromatin Protein 1 gen
    MIA TAUNA LEVINE; Fiscal Year: 2012
    ..Finally, I will apply my comprehensive approach to HP1 annotation and verification to higher primates, including humans...
  47. Physiology and structure of prefrontal projections to memory and motor circuits
    Maria Medalla; Fiscal Year: 2013
    ..Jennifer Luebke, one of the few world experts in whole-cell patch clamp in vitro slice recording techniques in primates. The project will also benefit from the support of collaborators, Dr...
  48. Translating a CSF delivered AAV9-SMN for treatment of Spinal Muscular Atrophy
    Brian K Kaspar; Fiscal Year: 2013
    ..AAV9-SMN in the 7 mouse model of SMA to support a pre-IND Aim 2: Optimize intrathecal dosing in nonhuman primates for most efficient targeting of spinal motor neurons using scAAV9.CB...
  49. Udall Parkinson's Disease Center at Emory University: Circuitry to Therapy
    THOMAS N WICHMANN; Fiscal Year: 2013 the clinical movement disorders group at Emory, the fact that a portion of the research will be carried out in primates at the Yerkes National Primate Research Center, and the Center's connection to an active population of ..
  50. Role of Fetal Steroids in Formation and Activation of Bovine Ovarian Follicles
    Joanne E Fortune; Fiscal Year: 2010
    ..In large mammals, such as cattle, sheep and primates (including humans) the primordial follicles form when the female is a fetus and virtually nothing is known about ..
  51. Developmental neurotoxicity of sarin and soman in guinea pigs
    Edson X Albuquerque; Fiscal Year: 2012
    ..model of choice because: (i) brain development of guinea pigs closely resembles that of humans and non-human primates and (ii) like humans, guinea pigs have low levels of circulating carboxylesterases - the enzymes that ..
  52. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
    ..The rapidity with which MHC class I and KIR evolve is such that only the higher non-human primates (apes and monkeys) have equivalents to the human components and thus these species provide the most valid animal ..
  53. K777 for treatment of Chagas Disease: IND-enabling Studies and IND Submission
    Robert Don; Fiscal Year: 2012 IV dose and two oral doses using the clinical formulation and a dose-range finding study in non-human primates, comparing three dose levels once daily as well as one cohort in divided doses to determine if bid dosing has an ..
  54. New Inactivators of GABA Aminotransferase for Addiction
    Richard B Silverman; Fiscal Year: 2013
    ..It was shown by positron emission tomography (PET) in primates that vigabatrin inhibits these cocaine-induced dopamine increases...
  55. An engineered meningococcal OMV vaccine for Africa against all capsular groups
    Dan M Granoff; Fiscal Year: 2013
    ..We will immunize mice and infant primates and measure serum bactericidal antibody responses against strains from Africa...
    Ned H Kalin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In humans and nonhuman primates, anxious temperament (AT) is a trait-like phenotype that is evident early in life and characterized by increased behavioral and physiological reactivity to mildly ..
  57. Maternal nutrient restriction: Effects on offspring immune function
    Mark J Nijland; Fiscal Year: 2013
    ..To address the effects of MNR (maternal nutrient restriction) on developmental programming in non-human primates (NHP), the Center for Pregnancy and Newborn Research has developed a cohort of baboon offspring whose mothers ..
  58. Development of Therapeutic Pan-Filovirus Macaque Monoclonal Antibodies
    Sven G Enterlein; Fiscal Year: 2013
    ..and analyzed for high-affinity antibodies in the CellSpot platform optimized for antibodies from nonhuman primates. RNA from B cell clones that produce cross-species binding antibodies will be extracted and the heavy and light ..
  59. Foxp2 regulation of sex specific transcriptional pathways and brain development
    JERALD MICHAEL BOWERS; Fiscal Year: 2013
    ..known to play a central role in the development of vocalizations in a wide variety of animal species including primates. It has also been hypothesized that exposure to increased levels of androgens, during prenatal development, ..
  60. Transgenerational Inheritance of Epigenetic Effects of Polychlorinated Biphenyls
    Charles V Vorhees; Fiscal Year: 2013
    ..Other experimental evidence in rodents and primates strongly suggests a transgenerational impact of in utero exposure as the cause of abnormal fetal neurodevelopment ..
  61. Functional genetic evolution of human brain and behavior
    Eric J Vallender; Fiscal Year: 2013
    ..disorders and allow for the development of more appropriate genetic models of these diseases in non-human primates. Here we propose to catalog the complete MAOA locus across primate species, including polymorphic variation in ..
  62. Novel Adeno-Associated Viral Therapy for X-linked Retinitis Pigmentosa
    James M Wilson; Fiscal Year: 2010
    ..The promoters will also be used with a reporter gene in normal mice and non-human primates to confirm that both are stable for long-term transgene expression...
  63. Surrogate endpoints for correlating protective immunity in response to influenza
    Gary Fujii; Fiscal Year: 2010 to confirm that the L-IAVM2e1-HD vaccine will provide similar protective immunity in ferrets and non-human primates. Comparative evaluation of the L-IAVM2e1-HD vaccine in ferrets and non-human primates are important studies ..
    Karol Sestak; Fiscal Year: 2009
    ..It was established by our group and others that in colonies with captive non-human primates (NHP), diarrhea is the leading cause of animal morbidity requiring veterinary care...
    Mady Hornig; Fiscal Year: 2002
    ..Natural infection has been confirmed only in horses, sheep, cattle, birds, and cats; however, primates can be infected experimentally...
    M Izard; Fiscal Year: 1999
    Nonhuman primates, phylogenetically our closest living relatives, have always been a very important model for studying human disease entities...
  67. Assessment of the Immunogenicity and Protective Efficacy of a Multiagent DNA Vacc
    Connie Schmaljohn; Fiscal Year: 2010
    ..Marburg (MARV) viruses are NIAID Category A pathogens and cause severe hemorrhagic fevers in humans and nonhuman primates with mortalities as high as 90%...
  68. Primate Veterinarian Training at the WaNPRC
    Charlotte Hotchkiss; Fiscal Year: 2009
    Abstract: Nonhuman primates (NHP) are critical to biomedical and behavioral research and their importance in biomedical and behavioral research is well documented...
    MARK DUBACH; Fiscal Year: 1990
    ..Despite clear recognition that primates differ from rodents in neuroanatomey, neurochemistry, and behavior associated with the neostriatum, insufficient ..
  70. A Lassa Vaccine in primates with AIDS
    Maria Salvato; Fiscal Year: 2009
    A Lassa vaccine in primates with AIDS Lassa fever virus is a rodent-borne scourge in West Africa and, less has been classified as a Category A biothreat in the US because of its lethality and aerosol-transmissibility...