opossums

Summary

Summary: New World marsupials of the family Didelphidae. Opossums are omnivorous, largely nocturnal and arboreal MAMMALS, grow to about three feet in length, including the scaly prehensile tail, and have an abdominal pouch in which the young are carried at birth.

Top Publications

  1. ncbi Hormonal regulation of 25-hydroxyvitamin D3-1alpha-hydroxylase and 24-hydroxylase gene transcription in opossum kidney cells
    H J Armbrecht
    Geriatric Research, Education, and Clinical Center 11G JB, St Louis VA Medical Center, St Louis, MO 63125, USA
    Arch Biochem Biophys 409:298-304. 2003
  2. ncbi Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
    Tarjei S Mikkelsen
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 447:167-77. 2007
  3. ncbi Stimulation by parathyroid hormone of a NHERF-1-assembled complex consisting of the parathyroid hormone I receptor, phospholipase Cbeta, and actin increases intracellular calcium in opossum kidney cells
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 279:23550-8. 2004
  4. pmc Adaptive evolution of the venom-targeted vWF protein in opossums that eat pitvipers
    Sharon A Jansa
    Department of Ecology, Evolution and Behavior, and J F Bell Museum of Natural History, University of Minnesota, St Paul, Minnesota, United States of America
    PLoS ONE 6:e20997. 2011
  5. ncbi Experimental aerosol inoculation of Mycobacterium bovis in North American opossums (Didelphis virginiana)
    Scott D Fitzgerald
    Diagnostic Center for Population and Animal Health, Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, P O Box 30076, Lansing, Michigan 48909, USA
    J Wildl Dis 39:418-23. 2003
  6. ncbi Experimental inoculation of North American opossums (Didelphis virginiana) with Mycobacterium bovis
    Kelly L Diegel
    Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, P O Box 30076, Lansing, Michigan 48909, USA
    J Wildl Dis 38:275-81. 2002
  7. pmc Using genomic data to unravel the root of the placental mammal phylogeny
    William J Murphy
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Genome Res 17:413-21. 2007
  8. ncbi Interaction of MAP17 with NHERF3/4 induces translocation of the renal Na/Pi IIa transporter to the trans-Golgi
    Miguel A Lanaspa
    Laboratory of Molecular Toxicology, Univ of Zaragoza, Veterinary Faculty, Calle Miguel Servet 177, 50013 Zaragoza, Spain
    Am J Physiol Renal Physiol 292:F230-42. 2007
  9. ncbi The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene
    Laurent Duret
    Laboratoire de Biométrie et Biologie Évolutive UMR 5558, CNRS and Université Lyon 1, 16 rue Raphael Dubois, 69622 Villeurbanne Cedex, France
    Science 312:1653-5. 2006
  10. pmc Steatohepatitis in laboratory opossums exhibiting a high lipemic response to dietary cholesterol and fat
    Jeannie Chan
    Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA
    Am J Physiol Gastrointest Liver Physiol 303:G12-9. 2012

Research Grants

  1. INDUCTION OF MELANOMA WITH UV-A
    Ronald Ley; Fiscal Year: 2000
  2. FUNCTION OF THE PINEAL COMPLEX
    CHARLES RALPH; Fiscal Year: 1980
  3. Internal environment of the developing brain
    Norman Saunders; Fiscal Year: 2006
  4. LIFE-SHORTENING EFFECTS OF ENVIRONMENTAL UV EXPOSURE
    Ronald Ley; Fiscal Year: 1991
  5. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
  6. HOST FACTORS MEDIATE INVASION BY CAMPYLOBACTER JEJUNI
    LINDA MANSFIELD; Fiscal Year: 2002
  7. Matrilysin in Lung Epithelial Cell Migration
    John McGuire; Fiscal Year: 2007
  8. Generation of Genetically Attenuated Rickettsiae
    Abdu Azad; Fiscal Year: 2009
  9. Mechanistic Studies at the Host-pathogen Interface
    David McMurray; Fiscal Year: 2007
  10. Effects of Myostatin Deficiency on Bone Strength
    Mark Hamrick; Fiscal Year: 2007

Detail Information

Publications267 found, 100 shown here

  1. ncbi Hormonal regulation of 25-hydroxyvitamin D3-1alpha-hydroxylase and 24-hydroxylase gene transcription in opossum kidney cells
    H J Armbrecht
    Geriatric Research, Education, and Clinical Center 11G JB, St Louis VA Medical Center, St Louis, MO 63125, USA
    Arch Biochem Biophys 409:298-304. 2003
    ..This suggests that there may be important posttranscriptional regulation of CYP24 mRNA in the kidney...
  2. ncbi Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
    Tarjei S Mikkelsen
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 447:167-77. 2007
    ..A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation...
  3. ncbi Stimulation by parathyroid hormone of a NHERF-1-assembled complex consisting of the parathyroid hormone I receptor, phospholipase Cbeta, and actin increases intracellular calcium in opossum kidney cells
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 279:23550-8. 2004
    ..Thus, NHERF-1 assembles a signaling complex in the apical domains of OK cells that contains the PTH1R, PLCbeta, and the actin cytoskeleton. Disruption of this complex blocks the PTH mediated increases of intracellular calcium...
  4. pmc Adaptive evolution of the venom-targeted vWF protein in opossums that eat pitvipers
    Sharon A Jansa
    Department of Ecology, Evolution and Behavior, and J F Bell Museum of Natural History, University of Minnesota, St Paul, Minnesota, United States of America
    PLoS ONE 6:e20997. 2011
    ..Here we report such evidence from an unusual predator-prey relationship between opossums (Marsupialia: Didelphidae) and pitvipers (Serpentes: Crotalinae)...
  5. ncbi Experimental aerosol inoculation of Mycobacterium bovis in North American opossums (Didelphis virginiana)
    Scott D Fitzgerald
    Diagnostic Center for Population and Animal Health, Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, P O Box 30076, Lansing, Michigan 48909, USA
    J Wildl Dis 39:418-23. 2003
    The goal of this study was to evaluate the susceptibility of North American opossums (Didelphis virginiana) to aerosol inoculation of Mycobacterium bovis at two dose levels in order to gain information on disease pathogenesis, fecal ..
  6. ncbi Experimental inoculation of North American opossums (Didelphis virginiana) with Mycobacterium bovis
    Kelly L Diegel
    Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, P O Box 30076, Lansing, Michigan 48909, USA
    J Wildl Dis 38:275-81. 2002
    Eight North American opossums (Didelphis virginiana) were inoculated with 1 x 10(5) colony forming units of Mycobacterium bovis to investigate their potential as reservoir hosts for bovine tuberculosis in Michigan...
  7. pmc Using genomic data to unravel the root of the placental mammal phylogeny
    William J Murphy
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Genome Res 17:413-21. 2007
    ..We discuss the impacts of this topology on earlier phylogenetic reconstructions and repeat-based inferences of phylogeny...
  8. ncbi Interaction of MAP17 with NHERF3/4 induces translocation of the renal Na/Pi IIa transporter to the trans-Golgi
    Miguel A Lanaspa
    Laboratory of Molecular Toxicology, Univ of Zaragoza, Veterinary Faculty, Calle Miguel Servet 177, 50013 Zaragoza, Spain
    Am J Physiol Renal Physiol 292:F230-42. 2007
    ..Therefore, the interaction between MAP17, NHERF3/4, and NaPiIIa in the TGN could be an important intermediate or alternate path in the internalization of NaPiIIa...
  9. ncbi The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene
    Laurent Duret
    Laboratoire de Biométrie et Biologie Évolutive UMR 5558, CNRS and Université Lyon 1, 16 rue Raphael Dubois, 69622 Villeurbanne Cedex, France
    Science 312:1653-5. 2006
    ..This event occurred after the divergence between eutherians and marsupials, which suggests that mechanisms of dosage compensation have evolved independently in both lineages...
  10. pmc Steatohepatitis in laboratory opossums exhibiting a high lipemic response to dietary cholesterol and fat
    Jeannie Chan
    Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA
    Am J Physiol Gastrointest Liver Physiol 303:G12-9. 2012
    Plasma VLDL and LDL cholesterol were markedly elevated (>40-fold) in high-responding opossums, but moderately elevated (6-fold) in low-responding opossums after they had consumed a high-cholesterol and high-fat diet for 24 wk...
  11. pmc Differential expression of hepatic genes involved in cholesterol homeostasis in high- and low-responding strains of laboratory opossums
    Jeannie Chan
    Southwest National Primate Research Center, Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
    Metabolism 57:718-24. 2008
    ..lipoprotein and low-density lipoprotein (VLDL+LDL) cholesterol levels of 2 partially inbred strains of opossums (Monodelphis domestica) differ markedly when they are fed a high-cholesterol and low-fat (HCLF) diet...
  12. pmc Cranial anatomy of the earliest marsupials and the origin of opossums
    Inés Horovitz
    Department of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 4:e8278. 2009
    ....
  13. ncbi Copper-induced conformational change in a marsupial prion protein repeat peptide probed using FTIR spectroscopy
    Marsia Gustiananda
    Computational Molecular Biology and Drug Design Group, John Curtin School of Medical Research, Australian National University, Canberra
    FEBS Lett 512:38-42. 2002
    ..The copper-induced conformational change is pH dependent, and occurs at pH >7...
  14. ncbi Copper complex species within a fragment of the N-terminal repeat region in opossum PrP protein
    Laura I Vagliasindi
    Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Viale A Doria 6, 95125, Catania, Italy
    Dalton Trans 40:2441-50. 2011
    ..The [Cu(L)H(-2)] species formed by the Ac-PHPGGSNWGQ-NH(2) decapeptide, having a slightly lower stability, turned out to be less abundant and to exist within a narrow pH range...
  15. ncbi Different effects of arsenate and phosphonoformate on P(i) transport adaptation in opossum kidney cells
    Ricardo Villa-Bellosta
    Laboratory of Molecular Toxicology, Univ of Zaragoza, Zaragoza, Spain
    Am J Physiol Cell Physiol 297:C516-25. 2009
    ..To conclude, a mathematical definition of the adaptation process is reported, thereby explaining the limited changes in P(i) transport V(max)...
  16. ncbi Evidence for extended action of gonadal hormones on the organization of sexually dimorphic behavior and morphology in gray short-tailed opossums (Monodelphis domestica)
    B H Fadem
    Department of Psychiatry, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
    Horm Behav 39:113-20. 2001
    Male and female gray short-tailed opossums were gonadectomized (GDX), or treated with the estrogen receptor antagonist tamoxifen citrate (TX), or corn oil (OIL) (control) during the 5th postnatal week, a time period equivalent to the 3rd ..
  17. ncbi Na+/H+ exchanger-regulatory factor 1 mediates inhibition of phosphate transport by parathyroid hormone and second messengers by acting at multiple sites in opossum kidney cells
    Matthew J Mahon
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Endocrinol 17:2355-64. 2003
    ..These pathways may involve cooperativity between cAMP- and protein kinase C-dependent pathways or activation/inhibition of an unrecognized NHERF-1-dependent pathway(s)...
  18. ncbi Regeneration of supraspinal axons after complete transection of the thoracic spinal cord in neonatal opossums (Monodelphis domestica)
    Elizabeth Jane Fry
    Department of Pharmacology, University of Melbourne, Parkville, Victoria 3010, Australia
    J Comp Neurol 466:422-44. 2003
    ....
  19. ncbi Cell migration to the anterior and posterior divisions of the granule cell layer of the accessory olfactory bulb of adult opossums
    A Martinez-Marcos
    Department of Anatomy and Cell Biology, Box 5, Health Science Center at Brooklyn, State University of New York, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Brain Res Dev Brain Res 127:95-8. 2001
    ..One week postinjection, an increase of cells was detected in the granule layer but not in the glomerular or mitral/tufted cell layers. No evidence for differential addition of cells to the anterior and posterior divisions was observed...
  20. ncbi Firing properties of accessory olfactory bulb mitral/tufted cells in response to urine delivered to the vomeronasal organ of gray short-tailed opossums
    Jing Ji Zhang
    Department of Anatomy and Cell Biology, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Chem Senses 32:355-60. 2007
    ..Here we report that mitral/tufted (M/T) cells of the accessory olfactory bulb (AOB) of male opossums responded to female urine but not to male urine with two distinct patterns: excitation followed by inhibition or ..
  21. ncbi Identification and sequence analysis of an Mhc class II B gene in a marsupial (Monodelphis domestica)
    W H Stone
    Department of Biology, Trinity University, San Antonio, TX 78212 7200, USA
    Immunogenetics 49:461-3. 1999
  22. pmc Early development of the neural plate, neural crest and facial region of marsupials
    K K Smith
    Department of Biology, Duke University, Durham, NC 27708, USA
    J Anat 199:121-31. 2001
    ..These observations illustrate how development may be modified to produce evolutionary changes that distinguish taxa. Further, they suggest that development is not necessarily highly conserved, but instead may be quite plastic...
  23. ncbi Developmental changes of gene expression after spinal cord injury in neonatal opossums
    Miranda Mladinic
    SISSA, Department of Neurobiology, via Bonomea 265, 34136 Trieste, Italy
    Brain Res 1363:20-39. 2010
    ..In opossums there is a critical period of development when regeneration stops being possible: at 9 days postnatal cervical ..
  24. pmc The opossum genome: insights and opportunities from an alternative mammal
    Paul B Samollow
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
    Genome Res 18:1199-215. 2008
    ..domestica that are expanding its versatility as an experimental system for a broad range of research applications in basic biology and biomedically oriented research...
  25. ncbi Evolution of the "OR37" subfamily of olfactory receptors: a cross-species comparison
    Reiner Hoppe
    Institute of Physiology, University of Hohenheim, Garbenstrasse 30, 70593, Stuttgart, Germany
    J Mol Evol 62:460-72. 2006
    ..Together, these results reveal novel information concerning the phylogenetic origin and important evolutionary steps of the mammalian-specific OR37 olfactory receptor family...
  26. ncbi NHERF1 mutations and responsiveness of renal parathyroid hormone
    Zoubida Karim
    INSERM Unité 845, Universite Paris Descartes, Faculte de Medecine, Paris, France
    N Engl J Med 359:1128-35. 2008
    ..These NHERF1 mutations suggest a previously unrecognized cause of renal phosphate loss in humans...
  27. ncbi Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney
    X Y Zhai
    Department of Cell Biology, Institute of Anatomy and Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
    Kidney Int 58:1523-33. 2000
    ..Two giant glycoproteins, cubilin and megalin, constitute important endocytic receptors localized to the kidney proximal tubule...
  28. ncbi Probability of Trypanosoma cruzi transmission by Triatoma infestans (Hemiptera: Reduviidae) to the opossum Didelphis albiventris (Marsupialia: Didelphidae)
    J Rabinovich
    , Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Argentina
    Am J Trop Med Hyg 65:125-30. 2001
    The probability of Trypanosoma cruzi transmission to opossums by independent events of predation and fecal contamination during feeding ("biting") with positive Triatoma infestans was estimated...
  29. ncbi Reversal and convergence in marsupial chromosome evolution
    W Rens
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK
    Cytogenet Genome Res 102:282-90. 2003
    ..From these and other painting comparisons, we conclude that there have been at least three reversals of fusions by fissions, and at least three fusions or fissions that have occurred independently in different lineages...
  30. pmc Phylogenetic footprint analysis of IGF2 in extant mammals
    Jennifer R Weidman
    Department of Radiation Oncology, Duke University, Durham, North Carolina 27710, USA
    Genome Res 14:1726-32. 2004
    ....
  31. ncbi Spotted fever group Rickettsia in Dermacentor variabilis (Acari: Ixodidae) infesting raccoons (Carnivora: Procyonidae) and opossums (Marsupialia: Didelphimorphidae) in Tennessee
    T M Kollars
    Department of Entomology, US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    J Med Entomol 38:601-2. 2001
    ..1%) of adult Dermacentor variabilis Say removed from raccoons (Procyon lotor L.) and Virginia opossums (Didelphis virginiana Kerr) in western Tennessee...
  32. ncbi Molecular characterization of Sarcocystis neurona strains from opossums (Didelphis virginiana) and intermediate hosts from Central California
    Daniel Rejmanek
    Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Vet Parasitol 170:20-9. 2010
    ..b>Opossums (Didelphis virginiana), the only known definitive hosts for S...
  33. ncbi Cloning of the MHC class II DRB cDNA from the brushtail possum (Trichosurus vulpecula)
    M K Lam
    Department of Biological Sciences, Australasian Fauna Laboratories, Macquarie University, NSW 2109, North Ryde, Australia
    Immunol Lett 76:31-6. 2001
    ..The T. vulpecula sequence shared an average overall sequence identity of 75.4% at the deduced amino acid level with M. rufogriseus and M. domestica, respectively...
  34. pmc Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods
    Daniel Fuster
    Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
    Proc Natl Acad Sci U S A 101:10482-7. 2004
    ..Expressed in AP-1 cells, however, NHE1 is insensitive to these agents but remains sensitive to volume changes. Thus, changes of hydrophobic mismatch can modulate NHE1 but do not underlie its volume sensitivity...
  35. ncbi M6P/IGF2R imprinting evolution in mammals
    J K Killian
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell 5:707-16. 2000
    ..Unless there was convergent evolution of M6P/ IGF2R imprinting and receptor IGF2 binding in marsupials and eutherians, our results also demonstrate that these two functions evolved in a mammalian clade exclusive of monotremes...
  36. pmc Flea-borne rickettsioses: ecologic considerations
    A F Azad
    Department of Microbiology and Immunobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Emerg Infect Dis 3:319-27. 1997
    ..typhi has been replaced by a peridomestic animal cycle involving, e.g., free-ranging cats, dogs, and opossums and their fleas...
  37. pmc Ancient genomic architecture for mammalian olfactory receptor clusters
    Ronny Aloni
    Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genome Biol 7:R88. 2006
    ..Whole-genome sequence alignment nets of five mammals allow their comprehensive comparison, aimed at reconstructing the ancestral olfactory subgenome...
  38. pmc Transposon-free regions in mammalian genomes
    Cas Simons
    ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia
    Genome Res 16:164-72. 2006
    ....
  39. ncbi Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprinting
    T Yokomine
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima, Japan
    Cytogenet Genome Res 113:75-80. 2006
    ..We found that, while opossums had an orthologue for DNMT3L, chickens and fish did not have this gene...
  40. ncbi High prevalence of Trypanosoma rangeli and Trypanosoma cruzi in opossums and triatomids in a formerly-endemic area of Chagas disease in Southeast Brazil
    Luis Eduardo Ramirez
    Departamento de Ciências Biológicas Parasitologia, Faculdade de Medicina do Triangulo Mineiro, Av Getùlio Guaritá, S N, Uberaba, Minas Gerais, Brazil
    Acta Trop 84:189-98. 2002
    ..Here we report for the first time a high prevalence of T. rangeli in opossums and triatomids captured in peridomestic environments in a formerly-endemic area of Chagas disease in Southeast ..
  41. ncbi Impact of culture conditions, culture media volumes, and glucose content on metabolic properties of renal epithelial cell cultures. Are renal cells in tissue culture hypoxic?
    G Gstraunthaler
    Institute of Physiology, University of Innsbruck, Austria
    Cell Physiol Biochem 9:150-72. 1999
    ..Thus, changes in nutrient supply and oxygenation of renal epithelial cell cultures by altered culture media volumes dramatically influence metabolic rates and levels of enzyme activities, respectively...
  42. ncbi Mapping the distribution of the interstitial telomeric (TTAGGG)n sequences in eight species of Brazilian marsupials (Didelphidae) by FISH and the correlation with constitutive heterochromatin. Do ITS represent evidence for fusion events in American marsup
    J M Pagnozzi
    Departamento de Biologia, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, Brazil
    Cytogenet Genome Res 98:278-84. 2002
    ..We suggest that the interstitial (TTAGGG)(n) sequences are associated with satellite DNA and do not necessarily arise through chromosomal rearrangements...
  43. ncbi New DNA data from a transthyretin nuclear intron suggest an Oligocene to Miocene diversification of living South America opossums (Marsupialia: Didelphidae)
    Cynthia Steiner
    Laboratoire de Paléontologie, Phylogénie et Paléobiologie, Institut des Sciences de l Evolution UMR 5554 CNRS, Universite Montpellier II, Montpellier, France
    Mol Phylogenet Evol 35:363-79. 2005
    ..Nuclear markers supported the monophyly of medium and large-sized opossums Metachirus+(Chironectes, Lutreolina, Didelphis, Philander), and the paraphyly of mouse-sized opossums, with the ..
  44. pmc Exceptionally preserved North American Paleogene metatherians: adaptations and discovery of a major gap in the opossum fossil record
    Marcelo Sánchez-Villagra
    Palaeontologisches Institut und Museum, Karl Schmid Strasse 4, 8006 Zurich, Switzerland
    Biol Lett 3:318-22. 2007
    ..with a fossil record extending from the Cretaceous to the Miocene, has traditionally been allied with opossums (Didelphidae) based on fragmentary material, mainly dentitions...
  45. ncbi Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase reduce receptor-mediated endocytosis in opossum kidney cells
    James E Sidaway
    AstraZeneca, Safety Assessment, 23S37 69, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
    J Am Soc Nephrol 15:2258-65. 2004
    ..These data establish the possibility in principle that inhibition of HMG-CoA reductase by statins in proximal tubule cells may reduce tubular protein reabsorption...
  46. pmc Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter
    M F Pfister
    Institute of, University of Zurich, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 95:1909-14. 1998
    ....
  47. ncbi Endosomal alkalinization reduces Jmax and Km of albumin receptor-mediated endocytosis in OK cells
    M Gekle
    Department of Physiology, , Germany
    Am J Physiol 268:F899-906. 1995
    ..Endosomal alkalinization disturbs intracellular ligand handling and receptor trafficking, leading to a reduction of endocytotic capacity and affinity...
  48. ncbi Murine typhus: an unrecognized suburban vectorborne disease
    Rachel Civen
    Acute Communicable Disease Control Program, Los Angeles County Public Health Department, Los Angeles, California 90012, USA
    Clin Infect Dis 46:913-8. 2008
    ..Contrary to the classic rat-flea-rat cycle, the most important reservoirs of infection in these areas are opossums and cats. The cat flea, Ctenocephalides felis, has been identified as the principal vector...
  49. pmc Geographic association of Rickettsia felis-infected opossums with human murine typhus, Texas
    Ardys Boostrom
    Corpus Christi Nueces County Department of Public Health, Corpus Christi, Texas, USA
    Emerg Infect Dis 8:549-54. 2002
    ..R. felis has been associated with opossums and their fleas in Texas and California. Because R...
  50. ncbi Conservation of Dnmt1o cytosine methyltransferase in the marsupial Monodelphis domestica
    Feng Ding
    Genesis 36:209-13. 2003
    ..Thus, an essential component of imprinting in eutherian mammals is found in a marsupial species, suggesting that marsupials and eutherian mammals imprint their genes with the same methylation-dependent mechanism...
  51. pmc Effect of ezetimibe on plasma cholesterol levels, cholesterol absorption, and secretion of biliary cholesterol in laboratory opossums with high and low responses to dietary cholesterol
    Jeannie Chan
    Department of Genetics and Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Metabolism 57:1645-54. 2008
    Partially inbred lines of laboratory opossums differ in plasma low-density lipoprotein cholesterol concentration and cholesterol absorption on a high-cholesterol diet...
  52. ncbi Effect of peroxynitrite on motor function of the opossum esophagus
    A Uc
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 55242, USA
    Dig Dis Sci 46:30-7. 2001
    ..It is possible that some of the esophageal motor dysfunction seen with esophagitis may be related to the formation of ONOO-...
  53. ncbi Effect of endotoxin on opossum oesophageal motor function
    H Park
    Department of Internal Medicine, University of Iowa, College of Medicine and VA Medical Center, Iowa City, USA
    Neurogastroenterol Motil 12:215-21. 2000
    ..The increase in plasma nitrite/nitrate was attenuated by AG. These studies support the hypothesis that endotoxin modulates oesophageal motor function by increasing NO production and suggest that this results from the induction of iNOS...
  54. ncbi Cholesterol absorption and hepatic acyl-coenzyme A:cholesterol acyltransferase activity play major roles in lipemic response to dietary cholesterol and fat in laboratory opossums
    Rampratap S Kushwaha
    Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
    Metabolism 53:817-22. 2004
    Partially inbred lines of laboratory opossums differ considerably in their low-density lipoprotein (LDL) cholesterol responses to dietary cholesterol and fat...
  55. pmc The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells
    Yuanli Li
    Dept of Internal Medicine, Section of Nephrology, Yale Univ School of Medicine, 300 Cedar St, TAC S255, P O Box 208029, New Haven, CT 06520 8029, USA
    Am J Physiol Cell Physiol 295:C529-37. 2008
    ....
  56. ncbi Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium
    Hiroki Inoue
    Department of Biological Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
    Biol Pharm Bull 26:148-55. 2003
    ..These results suggest that CHP2 functions in the absorptive epithelium for the intestine with NHE(s)...
  57. ncbi Na+-independent transporters, LAT-2 and b0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell lines
    P Gomes
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 319 Porto, Portugal
    J Membr Biol 186:63-80. 2002
    ..LAT-2 was found equally important at the apical and basolateral membranes, whereas system b0,+ had a predominant distribution in apical membranes...
  58. ncbi Regulation of the renal type IIa Na/Pi cotransporter by cGMP
    D Bacic
    Institutes of Anatomy and Physiology, University of Zurich, Zurich, Switzerland
    Pflugers Arch 443:306-13. 2001
    ..Our findings document that cGMP-mediated regulation (ANP and NO) of type IIa Na/Pi-cotransporters also takes place via internalization of the transporter protein...
  59. ncbi Intracellular Na+ regulates dopamine and angiotensin II receptors availability at the plasma membrane and their cellular responses in renal epithelia
    Riad Efendiev
    College of Pharmacy, University of Houston, Houston, Texas 77204, USA
    J Biol Chem 278:28719-26. 2003
    ..Thus, one or more proteins may act as an intracellular Na+ concentration sensor and play a major regulatory role on the effect of hormones that regulate proximal tubule Na+ reabsorption...
  60. ncbi Na(+)/H(+) exchanger 3 is in large complexes in the center of the apical surface of proximal tubule-derived OK cells
    S Akhter
    Department of Medicine, Gastrointestinal Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
    Am J Physiol Cell Physiol 283:C927-40. 2002
    ..In the BB fraction, NHE3 is largely in the detergent-insoluble fraction in lipid rafts and/or in large heterogenous complexes ranging from approximately 400 to approximately 900 kDa...
  61. ncbi NHE3 serves as a molecular tool for cAMP-mediated regulation of receptor-mediated endocytosis
    Michael Gekle
    Physiologisches Institut, University of Wurzburg, 97070 Wurzburg, Germany
    Am J Physiol Renal Physiol 283:F549-58. 2002
    ..NHE3 transfection into deficient cells restores RME and the effects of cAMP. Thus our data show that NHE3 is important for cAMP sensitivity of clathrin-dependent RME...
  62. pmc Interaction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate
    Mikiko Ito
    Department of Nutrition, Tokushima University, School of Medicine, Kuramoto cho 3 18 15, Tokushima City 770 8503, Japan
    Biochem J 377:607-16. 2004
    ..In conclusion, the present study indicates that PEX19 may be actively involved in controlling the internalization and trafficking of the Na/P(i) IIa co-transporter...
  63. ncbi Insulin activates Na(+)/H(+) exchanger 3: biphasic response and glucocorticoid dependence
    Jelena Klisic
    Department of Physiology, University of Zurich Irchel, CH 8057 Zurich, Switzerland
    Am J Physiol Renal Physiol 283:F532-9. 2002
    ....
  64. ncbi Glucagon acutely inhibits but chronically activates Na(+)/H(+) antiporter 3 activity in OKP cells
    Morimasa Amemiya
    Department of Internal Medicine, Division of Nephrology, Jichi Medical School, Tochigi, Japan
    Exp Nephrol 10:26-33. 2002
    ..In the present study, we examined the direct effect of glucagon on the opossum kidney P (OKP) cell Na(+)/H(+) antiporter, encoded by NHE3...
  65. ncbi Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cells
    Adriana C C Girardi
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
    Am J Physiol Cell Physiol 287:C1238-45. 2004
    ..We conclude that DPPIV plays an unexpected role in modulating Na+/H+ exchange mediated by NHE3 in proximal tubule cells...
  66. ncbi Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria
    Christopher L Brett
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Am J Physiol Cell Physiol 282:C1031-41. 2002
    ..These results suggest that, like its homologs in yeast and plants, NHE6 is an endosomal Na(+)/H(+) exchanger that may regulate intravesicular pH and volume and contribute to lysosomal biogenesis...
  67. ncbi Stimulation of NHE3 in OKP cells by an autocrine mechanism
    Morimasa Amemiya
    Department of Internal Medicine, Division of Nephrology, Jichi Omiya Medical Center, Jichi Medical School, Saitama shi, Saitama Ken, Japan
    Nephron Exp Nephrol 96:e23-30. 2004
    ..Chronic hypokalemia increases NHE3 activity in OKP cells. The aim of the present study was to determine whether an autocrine mechanism is involved in this activation...
  68. ncbi Na+/H+ exchanger NHE3 activity and trafficking are lipid Raft-dependent
    Rakhilya Murtazina
    Departments of Physiology and Medicine, Division of Gastroenterology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    J Biol Chem 281:17845-55. 2006
    ....
  69. ncbi Quaternary structure and apical membrane sorting of the mammalian NaSi-1 sulfate transporter in renal cell lines
    Ralf R Regeer
    Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia
    Int J Biochem Cell Biol 39:2240-51. 2007
    ..Our data demonstrates that NaSi-1 forms a dimeric protein which is glycosylated at N591, whose sorting to the apical membrane in renal epithelial cells is brefeldin A-sensitive and independent of lipid rafts or glycosylation...
  70. ncbi Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney
    Mohammad Saifur Rohman
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School, Kobe, Japan
    Kidney Int 67:1410-9. 2005
    ..However, little is known about the molecular cascade from the clock gene oscillators to cellular function...
  71. pmc Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis
    I Alexandru Bobulescu
    Univ of Texas Southwestern Medical Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 289:F685-91. 2005
    ....
  72. ncbi Parathyroid hormone regulation of NA+,K+-ATPase requires the PDZ 1 domain of sodium hydrogen exchanger regulatory factor-1 in opossum kidney cells
    Syed Jalal Khundmiri
    Department of Medicine, University of Louisville, Kidney Disease Program, Louisville, KY 40202, USA
    J Am Soc Nephrol 16:2598-607. 2005
    ..These results demonstrate that NHERF-1 is necessary for PTH-mediated inhibition of Na+,K+-ATPase activity and that the inhibition is mediated through the PDZ1, not PDZ2, domain...
  73. ncbi Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing
    E Silva
    Faculty of Medicine, Institute of Pharmacology and Therapeutics, 4200 319, Porto, Portugal
    J Membr Biol 212:163-75. 2006
    ..Ouabain (100 nM: ) increased alpha(1)-subunit, but not beta(1)-subunit, Na(+)/K(+)-ATPase expression in aged cells only. These cells constitute an interesting model for the study of renal epithelial cell ageing...
  74. ncbi Membrane curvature alters the activation kinetics of the epithelial Na+/H+ exchanger, NHE3
    R Todd Alexander
    Department of Pediatrics, Program in Cell Biology, and Program in Computational Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 282:7376-84. 2007
    ..We conclude that NHE3 exists in multiple states and that different physiological parameters control the transitions between them...
  75. ncbi The role played by endocytosis in albumin-induced secretion of TGF-beta1 by proximal tubular epithelial cells
    Ramaswamy Diwakar
    South West Thames Institute for Renal Research, St Helier Hospital, Carshalton, Surrey, United Kingdom
    Am J Physiol Renal Physiol 292:F1464-70. 2007
    ..Moreover, we found that albumin-induced TGF-beta(1) secretion by PTECs is not dependent on its interaction with megalin...
  76. pmc Characterization of the regulation of renal Na+/H+ exchanger NHE3 by insulin
    Daniel G Fuster
    Department of Internal Medicine, University of Texas Southwestern Medical Ctr, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 292:F577-85. 2007
    ..In summary, insulin stimulates NHE3 acutely via yet undefined pathways and mechanisms. The chronic effect of insulin is mediated by the classic PI3K-SGK1 route...
  77. ncbi A human orphan calcitonin receptor-like structure
    B Fluhmann
    Department of Orthopaedic Surgery, University of Zurich, Switzerland
    Biochem Biophys Res Commun 206:341-7. 1995
    ..The receptor-like protein whose ligand remains to be discovered belongs to the family of receptors of calcitonin, parathyroid hormone, secretin, vasointestinal peptide and pituitary adenylate cyclase-activating polypeptide...
  78. ncbi Regulation of Na+/H+ exchanger-NHE3 by angiotensin-II in OKP cells
    Liping Xu
    Department of Pediatrics and Physiology, Steele Children s Research Center, University of Arizona Health Sciences Center, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    Biochim Biophys Acta 1758:519-26. 2006
    ..We conclude that a transcriptional mechanism is at least partially responsible for the chronic effects of A-II treatment on renal NHE3 activity...
  79. ncbi Insulin treatment enhances AT1 receptor function in OK cells
    Anees Ahmad Banday
    Heart and Kidney Institute, College of Pharmacy, University of Houston, TX 77204, USA
    Am J Physiol Renal Physiol 288:F1213-9. 2005
    ....
  80. ncbi Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule
    Zhiying Zou
    Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06520 8029, USA
    J Biol Chem 279:34302-10. 2004
    ..We postulate that the enzymatic processing of megalin represents part of a novel ligand-dependent signaling pathway in the proximal tubule that links receptor-mediated endocytosis with cell signaling...
  81. ncbi Ouabain-insensitive acidification by dopamine in renal OK cells: primary control of the Na(+)/H(+) exchanger
    P Gomes
    Faculty of Medicine, Institute of Pharmacology and Therapeutics, 4200 Porto, Portugal
    Am J Physiol Regul Integr Comp Physiol 281:R10-8. 2001
    ....
  82. ncbi Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sites
    Hetal S Kocinsky
    Department of Pediatrics, Yale School of Medicine, New Haven, CT 06520 8029, USA
    Am J Physiol Renal Physiol 289:F249-58. 2005
    ..In conclusion, we successfully generated phosphospecific antibodies that should be useful to assess the phosphorylation of endogenous NHE3 at its two PKA consensus sites under a variety of physiological conditions in vitro and in vivo...
  83. ncbi Novel regulatory function for NHERF-1 in Npt2a transcription
    Syed Jalal Khundmiri
    Department of Medicine, Univ of Louisville, Kidney Disease Program, 570 S Preston St, Suite 102, Louisville, KY 40202, USA
    Am J Physiol Renal Physiol 294:F840-9. 2008
    ..Our data demonstrate for the first time that NHERF-1 regulates Npt2a transcription and membrane insertion...
  84. ncbi Distinct signalling cascades downstream to Gsalpha coupled dopamine D1-like NHE3 inhibition in rat and opossum renal epithelial cells
    Rui Pedrosa
    Institute of Pharmacology Therapeutics, Faculty of Medicine, Porto, Portugal
    Cell Physiol Biochem 14:91-100. 2004
    ..By contrast, the D1-mediated inhibition of NHE3 in renal opossum cells involves a peculiar mechanism with AC-PKA and PLC-PKC pathways...
  85. ncbi ET(B) receptor activation causes exocytic insertion of NHE3 in OKP cells
    Y Peng
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Am J Physiol Renal Physiol 280:F34-42. 2001
    ..These studies demonstrate that ET-1 induces net trafficking of NHE3 to the apical membrane that is mediated by enhanced exocytic insertion and is required for increased NHE3 activity...
  86. ncbi The use of High Performance Thin-Layer Chromatography to determine the role of membrane lipid composition in bile salt-induced kidney cell damage
    Winston A Morgan
    School of Health and Bioscience, University of East London, Romford Road, London E15 4LZ, United Kingdom
    J Pharmacol Toxicol Methods 57:70-3. 2008
    ..In obstructive liver disease bile salts are known to accumulate in and damage specific kidney cells. High Performance Thin-Layer Chromatography (HPTLC) was used to determine the membrane lipid composition of a range of kidney cells...
  87. ncbi Lysophosphatidic acid induces exocytic trafficking of Na(+)/H(+) exchanger 3 by E3KARP-dependent activation of phospholipase C
    Jung Woong Choi
    Department of Physiology and Medicine, Gastrointestinal Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biochim Biophys Acta 1683:59-68. 2004
    ....
  88. pmc Effect of renal lipid accumulation on proximal tubule Na+/H+ exchange and ammonium secretion
    I Alexandru Bobulescu
    Dept of Internal Medicine, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 294:F1315-22. 2008
    ..These findings suggest that renal steatosis decreases ammonium secretion in the proximal tubule, in part by reducing NHE3 activity and by impairing the regulation of NHE3 by specific agonists...
  89. ncbi Sarcocystis neurona (Protozoa: Apicomplexa): description of oocysts, sporocysts, sporozoites, excystation, and early development
    David S Lindsay
    Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, 24061 0342, USA
    J Parasitol 90:461-5. 2004
    ..Sporozoites contained 2-4 electron-dense rhoptries and other organelles typical of coccidian zoites. Sporozoites entered host cells in culture and underwent schizogony within 3 days...
  90. ncbi Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na(+)-K(+)-ATPase activity
    Pedro Gomes
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 Porto, Portugal
    Am J Physiol Renal Physiol 282:F1084-96. 2002
    ....
  91. ncbi Cofilin interacts with ClC-5 and regulates albumin uptake in proximal tubule cell lines
    Deanne H Hryciw
    Department of Physiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Biol Chem 278:40169-76. 2003
    ..This study identifies a novel interaction between the C-terminal tail of ClC-5 and cofilin, an actin-associated protein that is crucial in the regulation of albumin uptake by the proximal tubule...
  92. ncbi The rBAT gene is responsible for L-cystine uptake via the b0,(+)-like amino acid transport system in a "renal proximal tubular" cell line (OK cells)
    C Mora
    Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Spain
    J Biol Chem 271:10569-76. 1996
    ..These results demonstrate that rBAT is functionally related to the L-cystine uptake via system b0,(+)-like in the apical pole of the renal OK cell line...
  93. ncbi Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cells
    Eleanor DeLand Lederer
    Louisville Veterans Administration Medical Center, Louisville, Kentucky, USA
    J Am Soc Nephrol 14:1711-9. 2003
    ..These experiments also suggest that the mechanism for retrieval of NaPi IIa transporters from the apical membrane in response to cAMP does not require NHERF...
  94. ncbi Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cells
    N M Al-Rasheed
    Department of Cell Physiology and Pharmacology, Faculty of Medicine and Biological Sciences, University of Leicester, Medical Sciences Building, University Road, Leicester LE1 9HN, United Kingdom
    Diabetologia 47:987-97. 2004
    ..We therefore investigated the ability of C-peptide to stimulate intracellular signalling pathways in kidney proximal tubular cells, the altered activation of which may possibly be related to the development of diabetic nephropathy...
  95. ncbi Regulation of the procine 1,25-dihydroxyvitamin D3-24-hydroxylase (CYP24) by 1,25-dihydroxyvitamin D3 and parathyroid hormone in AOK-B50 cells
    C Zierold
    College of Agricultural and Life Sciences, Department of Biochemistry, University of Wisconsin Madison, 53706, USA
    Arch Biochem Biophys 381:323-7. 2000
    ..In view of the above findings we concluded that AOK-B50 cells are a suitable model for further studying the mechanism of action of PTH on 24-hydroxylase mRNA...
  96. ncbi Cytotoxicity of peroxisome proliferator-activated receptor alpha and gamma agonists in renal proximal tubular cell lines
    Hector Giral
    Laboratory of Molecular Toxicology, University of Zaragoza, E50013 Zaragoza, Spain
    Toxicol In Vitro 21:1066-76. 2007
    ..With these methods, no signs of apoptosis were observed, which suggests a direct necrosis of the compounds on these renal proximal tubular cell lines...
  97. ncbi Short-term regulation of basolateral organic anion uptake in proximal tubular OK cells: EGF acts via MAPK, PLA(2), and COX1
    Christoph Sauvant
    Physiologisches Institut der Universität Würzburg, Wurzburg, Germany
    J Am Soc Nephrol 13:1981-91. 2002
    ..Subsequently, arachidonic acid is metabolized to prostaglandins via COX1, which then mediate EGF-induced stimulation of basolateral organic anion uptake rate...
  98. ncbi Unique uptake and efflux systems of inorganic phosphate in osteoclast-like cells
    Mikiko Ito
    Department of Molecular Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto cho 3 18 15, Tokushima City 770 8503, Japan
    Am J Physiol Cell Physiol 292:C526-34. 2007
    ..These results suggest that osteoclast-like cells have a unique P(i) uptake/efflux system and can prevent P(i) accumulation within osteoclast hemivacuoles...
  99. ncbi Bimodal acute effects of A1 adenosine receptor activation on Na+/H+ exchanger 3 in opossum kidney cells
    Francesca Di Sole
    Department of Physiology and Pathophysiology, Division of Vegetative Physiology and Pathophysiology, Georg August University of Goettingen, Humboldtallee 23, D 37073 Goettingen, Germany
    J Am Soc Nephrol 14:1720-30. 2003
    ....
  100. ncbi Expression and function of sodium transporters in two opossum kidney cell clonal sublines
    Pedro Gomes
    Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 319 Porto, Portugal
    Am J Physiol Renal Physiol 283:F73-85. 2002
    ..It is suggested that OK(LC) and OK(HC) cells constitute an interesting cell model for the study of renal epithelial physiology and pathophysiology, namely, hypertension...
  101. ncbi C-peptide signals via Galpha i to protect against TNF-alpha-mediated apoptosis of opossum kidney proximal tubular cells
    Nawal M Al-Rasheed
    Department of Nephrology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    J Am Soc Nephrol 17:986-95. 2006
    ..The data further support the concept of C-peptide as a peptide hormone in its own right and suggest a potential therapeutic role for C-peptide...

Research Grants38

  1. INDUCTION OF MELANOMA WITH UV-A
    Ronald Ley; Fiscal Year: 2000
    ..Groups of opossums will be exposed to graded doses of UV-A three times per week for up to 104 wee Animals will be monitored to ..
  2. FUNCTION OF THE PINEAL COMPLEX
    CHARLES RALPH; Fiscal Year: 1980
    ..temperature and metabolism, using ectotherms (lizards, alligators, snakes) and endotherms (squirrels, armadillos, opossums)...
  3. Internal environment of the developing brain
    Norman Saunders; Fiscal Year: 2006
    ..The studies will be in S. American opossums (Monodelphis domestica); they are born at a very early stage of brain development (equivalent to 13 day fetal ..
  4. LIFE-SHORTENING EFFECTS OF ENVIRONMENTAL UV EXPOSURE
    Ronald Ley; Fiscal Year: 1991
    ..that photoreactivating treatment also partially abrogates the life-shortening effect of chronic UV exposure in opossums. We wish to explore in detail the life-shortening effect of chronic UV exposure...
  5. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
    ..Furthermore, these cells can survive in the environment of the eye and have the ability to integrate within the inner retina to serve as delivery vehicles for therapeutic proteins. ..
  6. HOST FACTORS MEDIATE INVASION BY CAMPYLOBACTER JEJUNI
    LINDA MANSFIELD; Fiscal Year: 2002
    ..jejuni invasion is facilitated due to a direct effect of some secreted/excreted product of the worms, and 4) Determine what host cell genes are differentially expressed during C. jejuni invasion. ..
  7. Matrilysin in Lung Epithelial Cell Migration
    John McGuire; Fiscal Year: 2007
    ..McGuire will have the opportunity to develop experience and expertise in the application of basic techniques and approaches in molecular biology, cell biology, and protein biochemistry to fundamental questions in pulmonary biology. ..
  8. Generation of Genetically Attenuated Rickettsiae
    Abdu Azad; Fiscal Year: 2009
    ..The underlying hypothesis tested is whether recombinant strains with altered genes maintain their immunogenicity within mammals and provide cross protection to subsequent challenge with virulent strains. ..
  9. Mechanistic Studies at the Host-pathogen Interface
    David McMurray; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  10. Effects of Myostatin Deficiency on Bone Strength
    Mark Hamrick; Fiscal Year: 2007
    ..abstract_text> ..
  11. SPARING AND EXERCISE TRAINING PROMOTE RECOVERY IN SCI
    Michele Basso; Fiscal Year: 2006
    ..abstract_text> ..
  12. Role of MRP2 and MRP4 in renal organic anion excretion
    RYAN PELIS; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. Murine Typhus: Vector Biology & Transmission
    Abdu Azad; Fiscal Year: 2007
    ..typhi and ELB isolates[unreadable] obtained from opossums and humans...
  14. Improved Molecular Imaging with SPECT
    Mathew Thakur; Fiscal Year: 2006
    ..It also takes advantage of adapting existing clinical SPECT machines, rather than developing a dedicated small animal imaging system, which makes it much less expensive and more widely available. [unreadable] [unreadable]..
  15. Polymicrobial Associations in Inflammatory Bowel Disease
    GERALD DUHAMEL; Fiscal Year: 2006
    ..abstract_text> ..
  16. IMMUNE PROTECTION AGAINST MNU-INDUCTED DIGITAL DEFECTS
    MARY PRATER; Fiscal Year: 2006
    ..This research under the guidance of Drs. Steven Holladay and Eric Wong at Virginia Tech...
  17. Natural ligands for 2 endothelin-like orphan receptors
    Rainer Reinscheid; Fiscal Year: 2004
    ..Identification of the natural ligands will enable us to study the physiological functions of these two orphan GPCRs under normal and pathological conditions. ..
  18. Mechanistic Role of Peroxynitrite in Gallbladder Disease
    JOSEPH CULLEN; Fiscal Year: 2004
    ..In addition, it is expected that the results will fundamentally advance the field of free radical biology and gallbladder physiology. ..
  19. Agmatine Mediated Arrest of Proliferation
    Joseph Satriano; Fiscal Year: 2003
    ..UCSD has established itself as a leading academic institution and thus provides an excellent environment for the exchange of ideas and techniques essential for the growth of the PI's career. ..
  20. DIETARY DEFICIENCIES AND TUBERCULOSIS VACCINE EFFICACY
    David McMurray; Fiscal Year: 2009
    ..abstract_text> ..
  21. Mechanism/regulation of human intestinal thiamin uptake
    HAMID SAID; Fiscal Year: 2008
    ..This should ultimately assist us in the designing of effective strategies to optimize thiamin body homeostasis in conditions associated with thiamin deficiency and sub-optimal levels. ..
  22. Physiological Functions of Neuropeptide S
    Rainer Reinscheid; Fiscal Year: 2009
    ..We will study the pharmacology of the mutant receptor isoforms which may help to understand the physiological consequences of the mutation in human airway tissue. ..
  23. Gene Expression Arrays for the Laboratory Opossum
    PAUL SAMOLLOW; Fiscal Year: 2009
    ..An explicit objective of the proposed study is to make these cDNA libraries, gene arrays, and database resources fully accessible to the research community. ..
  24. Ets-1 Expression in Squamous Cells of the Oral Cavity
    LEE GARRETT SINHA; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  25. Genotypic and Phenotypic Analysis of West Nile virus, Yucatan Peninsula of Mexico
    Bradley Blitvich; Fiscal Year: 2008
    ..This information will help determine why there has not been an epidemic of WNV in the YP, and will identify risk factors associated with WNV disease. [unreadable] [unreadable] [unreadable]..
  26. PET for Molecular Imaging of Small Animals
    Mathew Thakur; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. PET Imaging of Breast Cancer Using Oncogene Expression
    Mathew Thakur; Fiscal Year: 2008
    ..abstract_text> ..
  28. C elegans:a model to study intestinal water-soluble vitamins transport in vivo
    HAMID SAID; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  29. OPOSSUM MODEL FOR THE HIGH & LOW RESPONSES TO DIET
    RAMPRATAP KUSHWAHA; Fiscal Year: 2004
    ..Partially inbred strains of opossums exhibit individual differences in very low (VLDL) and low (LDL) density lipoprotein cholesterol concentrations in ..
  30. Tool to Define the Antiproliferative Effects of Agmatine
    Joseph Satriano; Fiscal Year: 2006
    ..These pathways will have particular application to diabetes and IRI in kidney, models we plan to pursue. [unreadable] [unreadable]..
  31. Oxidative Stress Attenuates Na+:Ca+ Exchanger Activity
    MENJOR UNLAP; Fiscal Year: 2005
    ..We will examine exchanger nitration, phosphorylation, and translocation under oxidative stress conditions and determine how they relate to the attenuation of exchanger activity. ..
  32. BIOLOGY AND IMMUNOLOGY OF MALARIA PARASITE LIVER-STAGES
    Abdu Azad; Fiscal Year: 2005
    ..falciparum EE-stages. Finally, we will define the contribution of P. yoelii liver-stage gene products in protective immunity via DNA immunizations. ..
  33. GENETICS OF THYROID HORMONES IN MEXICAN AMERICANS
    PAUL SAMOLLOW; Fiscal Year: 2001
    ..QTL linkage analyses will be performed to test for linkage between genes that influence thyroid hormone variation and the two sets of genetic markers, i.e., candidate genes and STR markers. ..
  34. Carcinogenesis: Effects of Diet Deficient in Methyl Donors
    Shi Huang; Fiscal Year: 2007
    ..The new understanding that will emerge from these studies will help clarify the role of nutrient metabolism in carcinogenesis. The results may have important public health implications. ..
  35. Modulation of Diabetic Kidney Growth/ Hypertrophy
    Joseph Satriano; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  36. Mechanisms of Dicumarol-Induced Cytotoxicity
    JOSEPH CULLEN; Fiscal Year: 2007
    ..pancreatic cancer cells. [unreadable] [unreadable] [unreadable]..
  37. IMAGING THROMBOEMBOLISM WITH FIBRIN AVID TC-99M-PEPTIDE
    Mathew Thakur; Fiscal Year: 2002
    ..Because there are no agents currently available than can scintigraphically provide "hot spot" images of old (24 hr or older) clots and PE, the commercial potential for this agent is very high. ..