Genomes and Genes
Summary: New World marsupials of the family Didelphidae. Opossums are omnivorous, largely nocturnal and arboreal MAMMALS, grow to about three feet in length, including the scaly prehensile tail, and have an abdominal pouch in which the young are carried at birth.
Publications267 found, 100 shown here
- Hormonal regulation of 25-hydroxyvitamin D3-1alpha-hydroxylase and 24-hydroxylase gene transcription in opossum kidney cellsH J Armbrecht
Geriatric Research, Education, and Clinical Center 11G JB, St Louis VA Medical Center, St Louis, MO 63125, USA
Arch Biochem Biophys 409:298-304. 2003..This suggests that there may be important posttranscriptional regulation of CYP24 mRNA in the kidney...
- Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequencesTarjei S Mikkelsen
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 447:167-77. 2007..A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation...
- Stimulation by parathyroid hormone of a NHERF-1-assembled complex consisting of the parathyroid hormone I receptor, phospholipase Cbeta, and actin increases intracellular calcium in opossum kidney cellsMatthew J Mahon
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Biol Chem 279:23550-8. 2004..Thus, NHERF-1 assembles a signaling complex in the apical domains of OK cells that contains the PTH1R, PLCbeta, and the actin cytoskeleton. Disruption of this complex blocks the PTH mediated increases of intracellular calcium...
- Adaptive evolution of the venom-targeted vWF protein in opossums that eat pitvipersSharon A Jansa
Department of Ecology, Evolution and Behavior, and J F Bell Museum of Natural History, University of Minnesota, St Paul, Minnesota, United States of America
PLoS ONE 6:e20997. 2011..Here we report such evidence from an unusual predator-prey relationship between opossums (Marsupialia: Didelphidae) and pitvipers (Serpentes: Crotalinae)...
- Experimental aerosol inoculation of Mycobacterium bovis in North American opossums (Didelphis virginiana)Scott D Fitzgerald
Diagnostic Center for Population and Animal Health, Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, P O Box 30076, Lansing, Michigan 48909, USA
J Wildl Dis 39:418-23. 2003The goal of this study was to evaluate the susceptibility of North American opossums (Didelphis virginiana) to aerosol inoculation of Mycobacterium bovis at two dose levels in order to gain information on disease pathogenesis, fecal ..
- Experimental inoculation of North American opossums (Didelphis virginiana) with Mycobacterium bovisKelly L Diegel
Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, P O Box 30076, Lansing, Michigan 48909, USA
J Wildl Dis 38:275-81. 2002Eight North American opossums (Didelphis virginiana) were inoculated with 1 x 10(5) colony forming units of Mycobacterium bovis to investigate their potential as reservoir hosts for bovine tuberculosis in Michigan...
- Using genomic data to unravel the root of the placental mammal phylogenyWilliam J Murphy
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
Genome Res 17:413-21. 2007..We discuss the impacts of this topology on earlier phylogenetic reconstructions and repeat-based inferences of phylogeny...
- Interaction of MAP17 with NHERF3/4 induces translocation of the renal Na/Pi IIa transporter to the trans-GolgiMiguel A Lanaspa
Laboratory of Molecular Toxicology, Univ of Zaragoza, Veterinary Faculty, Calle Miguel Servet 177, 50013 Zaragoza, Spain
Am J Physiol Renal Physiol 292:F230-42. 2007..Therefore, the interaction between MAP17, NHERF3/4, and NaPiIIa in the TGN could be an important intermediate or alternate path in the internalization of NaPiIIa...
- The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding geneLaurent Duret
Laboratoire de Biométrie et Biologie Évolutive UMR 5558, CNRS and Université Lyon 1, 16 rue Raphael Dubois, 69622 Villeurbanne Cedex, France
Science 312:1653-5. 2006..This event occurred after the divergence between eutherians and marsupials, which suggests that mechanisms of dosage compensation have evolved independently in both lineages...
- Steatohepatitis in laboratory opossums exhibiting a high lipemic response to dietary cholesterol and fatJeannie Chan
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX 78245, USA
Am J Physiol Gastrointest Liver Physiol 303:G12-9. 2012Plasma VLDL and LDL cholesterol were markedly elevated (>40-fold) in high-responding opossums, but moderately elevated (6-fold) in low-responding opossums after they had consumed a high-cholesterol and high-fat diet for 24 wk...
- Differential expression of hepatic genes involved in cholesterol homeostasis in high- and low-responding strains of laboratory opossumsJeannie Chan
Southwest National Primate Research Center, Department of Genetics, Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, TX 78245 0549, USA
Metabolism 57:718-24. 2008..lipoprotein and low-density lipoprotein (VLDL+LDL) cholesterol levels of 2 partially inbred strains of opossums (Monodelphis domestica) differ markedly when they are fed a high-cholesterol and low-fat (HCLF) diet...
- Cranial anatomy of the earliest marsupials and the origin of opossumsInés Horovitz
Department of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, California, USA
PLoS ONE 4:e8278. 2009....
- Copper-induced conformational change in a marsupial prion protein repeat peptide probed using FTIR spectroscopyMarsia Gustiananda
Computational Molecular Biology and Drug Design Group, John Curtin School of Medical Research, Australian National University, Canberra
FEBS Lett 512:38-42. 2002..The copper-induced conformational change is pH dependent, and occurs at pH >7...
- Copper complex species within a fragment of the N-terminal repeat region in opossum PrP proteinLaura I Vagliasindi
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Viale A Doria 6, 95125, Catania, Italy
Dalton Trans 40:2441-50. 2011..The [Cu(L)H(-2)] species formed by the Ac-PHPGGSNWGQ-NH(2) decapeptide, having a slightly lower stability, turned out to be less abundant and to exist within a narrow pH range...
- Different effects of arsenate and phosphonoformate on P(i) transport adaptation in opossum kidney cellsRicardo Villa-Bellosta
Laboratory of Molecular Toxicology, Univ of Zaragoza, Zaragoza, Spain
Am J Physiol Cell Physiol 297:C516-25. 2009..To conclude, a mathematical definition of the adaptation process is reported, thereby explaining the limited changes in P(i) transport V(max)...
- Evidence for extended action of gonadal hormones on the organization of sexually dimorphic behavior and morphology in gray short-tailed opossums (Monodelphis domestica)B H Fadem
Department of Psychiatry, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA
Horm Behav 39:113-20. 2001Male and female gray short-tailed opossums were gonadectomized (GDX), or treated with the estrogen receptor antagonist tamoxifen citrate (TX), or corn oil (OIL) (control) during the 5th postnatal week, a time period equivalent to the 3rd ..
- Na+/H+ exchanger-regulatory factor 1 mediates inhibition of phosphate transport by parathyroid hormone and second messengers by acting at multiple sites in opossum kidney cellsMatthew J Mahon
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Mol Endocrinol 17:2355-64. 2003..These pathways may involve cooperativity between cAMP- and protein kinase C-dependent pathways or activation/inhibition of an unrecognized NHERF-1-dependent pathway(s)...
- Regeneration of supraspinal axons after complete transection of the thoracic spinal cord in neonatal opossums (Monodelphis domestica)Elizabeth Jane Fry
Department of Pharmacology, University of Melbourne, Parkville, Victoria 3010, Australia
J Comp Neurol 466:422-44. 2003....
- Cell migration to the anterior and posterior divisions of the granule cell layer of the accessory olfactory bulb of adult opossumsA Martinez-Marcos
Department of Anatomy and Cell Biology, Box 5, Health Science Center at Brooklyn, State University of New York, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Brain Res Dev Brain Res 127:95-8. 2001..One week postinjection, an increase of cells was detected in the granule layer but not in the glomerular or mitral/tufted cell layers. No evidence for differential addition of cells to the anterior and posterior divisions was observed...
- Firing properties of accessory olfactory bulb mitral/tufted cells in response to urine delivered to the vomeronasal organ of gray short-tailed opossumsJing Ji Zhang
Department of Anatomy and Cell Biology, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Chem Senses 32:355-60. 2007..Here we report that mitral/tufted (M/T) cells of the accessory olfactory bulb (AOB) of male opossums responded to female urine but not to male urine with two distinct patterns: excitation followed by inhibition or ..
- Identification and sequence analysis of an Mhc class II B gene in a marsupial (Monodelphis domestica)W H Stone
Department of Biology, Trinity University, San Antonio, TX 78212 7200, USA
Immunogenetics 49:461-3. 1999
- Early development of the neural plate, neural crest and facial region of marsupialsK K Smith
Department of Biology, Duke University, Durham, NC 27708, USA
J Anat 199:121-31. 2001..These observations illustrate how development may be modified to produce evolutionary changes that distinguish taxa. Further, they suggest that development is not necessarily highly conserved, but instead may be quite plastic...
- Developmental changes of gene expression after spinal cord injury in neonatal opossumsMiranda Mladinic
SISSA, Department of Neurobiology, via Bonomea 265, 34136 Trieste, Italy
Brain Res 1363:20-39. 2010..In opossums there is a critical period of development when regeneration stops being possible: at 9 days postnatal cervical ..
- The opossum genome: insights and opportunities from an alternative mammalPaul B Samollow
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
Genome Res 18:1199-215. 2008..domestica that are expanding its versatility as an experimental system for a broad range of research applications in basic biology and biomedically oriented research...
- Evolution of the "OR37" subfamily of olfactory receptors: a cross-species comparisonReiner Hoppe
Institute of Physiology, University of Hohenheim, Garbenstrasse 30, 70593, Stuttgart, Germany
J Mol Evol 62:460-72. 2006..Together, these results reveal novel information concerning the phylogenetic origin and important evolutionary steps of the mammalian-specific OR37 olfactory receptor family...
- NHERF1 mutations and responsiveness of renal parathyroid hormoneZoubida Karim
INSERM Unité 845, Universite Paris Descartes, Faculte de Medecine, Paris, France
N Engl J Med 359:1128-35. 2008..These NHERF1 mutations suggest a previously unrecognized cause of renal phosphate loss in humans...
- Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidneyX Y Zhai
Department of Cell Biology, Institute of Anatomy and Department of Medical Biochemistry, University of Aarhus, Aarhus, Denmark
Kidney Int 58:1523-33. 2000..Two giant glycoproteins, cubilin and megalin, constitute important endocytic receptors localized to the kidney proximal tubule...
- Probability of Trypanosoma cruzi transmission by Triatoma infestans (Hemiptera: Reduviidae) to the opossum Didelphis albiventris (Marsupialia: Didelphidae)J Rabinovich
, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Argentina
Am J Trop Med Hyg 65:125-30. 2001The probability of Trypanosoma cruzi transmission to opossums by independent events of predation and fecal contamination during feeding ("biting") with positive Triatoma infestans was estimated...
- Reversal and convergence in marsupial chromosome evolutionW Rens
Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK
Cytogenet Genome Res 102:282-90. 2003..From these and other painting comparisons, we conclude that there have been at least three reversals of fusions by fissions, and at least three fusions or fissions that have occurred independently in different lineages...
- Phylogenetic footprint analysis of IGF2 in extant mammalsJennifer R Weidman
Department of Radiation Oncology, Duke University, Durham, North Carolina 27710, USA
Genome Res 14:1726-32. 2004....
- Spotted fever group Rickettsia in Dermacentor variabilis (Acari: Ixodidae) infesting raccoons (Carnivora: Procyonidae) and opossums (Marsupialia: Didelphimorphidae) in TennesseeT M Kollars
Department of Entomology, US Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
J Med Entomol 38:601-2. 2001..1%) of adult Dermacentor variabilis Say removed from raccoons (Procyon lotor L.) and Virginia opossums (Didelphis virginiana Kerr) in western Tennessee...
- Molecular characterization of Sarcocystis neurona strains from opossums (Didelphis virginiana) and intermediate hosts from Central CaliforniaDaniel Rejmanek
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
Vet Parasitol 170:20-9. 2010..b>Opossums (Didelphis virginiana), the only known definitive hosts for S...
- Cloning of the MHC class II DRB cDNA from the brushtail possum (Trichosurus vulpecula)M K Lam
Department of Biological Sciences, Australasian Fauna Laboratories, Macquarie University, NSW 2109, North Ryde, Australia
Immunol Lett 76:31-6. 2001..The T. vulpecula sequence shared an average overall sequence identity of 75.4% at the deduced amino acid level with M. rufogriseus and M. domestica, respectively...
- Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methodsDaniel Fuster
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
Proc Natl Acad Sci U S A 101:10482-7. 2004..Expressed in AP-1 cells, however, NHE1 is insensitive to these agents but remains sensitive to volume changes. Thus, changes of hydrophobic mismatch can modulate NHE1 but do not underlie its volume sensitivity...
- M6P/IGF2R imprinting evolution in mammalsJ K Killian
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Cell 5:707-16. 2000..Unless there was convergent evolution of M6P/ IGF2R imprinting and receptor IGF2 binding in marsupials and eutherians, our results also demonstrate that these two functions evolved in a mammalian clade exclusive of monotremes...
- Flea-borne rickettsioses: ecologic considerationsA F Azad
Department of Microbiology and Immunobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Emerg Infect Dis 3:319-27. 1997..typhi has been replaced by a peridomestic animal cycle involving, e.g., free-ranging cats, dogs, and opossums and their fleas...
- Ancient genomic architecture for mammalian olfactory receptor clustersRonny Aloni
Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel
Genome Biol 7:R88. 2006..Whole-genome sequence alignment nets of five mammals allow their comprehensive comparison, aimed at reconstructing the ancestral olfactory subgenome...
- Transposon-free regions in mammalian genomesCas Simons
ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane QLD 4072, Australia
Genome Res 16:164-72. 2006....
- Evolution of the vertebrate DNMT3 gene family: a possible link between existence of DNMT3L and genomic imprintingT Yokomine
Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima, Japan
Cytogenet Genome Res 113:75-80. 2006..We found that, while opossums had an orthologue for DNMT3L, chickens and fish did not have this gene...
- High prevalence of Trypanosoma rangeli and Trypanosoma cruzi in opossums and triatomids in a formerly-endemic area of Chagas disease in Southeast BrazilLuis Eduardo Ramirez
Departamento de Ciências Biológicas Parasitologia, Faculdade de Medicina do Triangulo Mineiro, Av Getùlio Guaritá, S N, Uberaba, Minas Gerais, Brazil
Acta Trop 84:189-98. 2002..Here we report for the first time a high prevalence of T. rangeli in opossums and triatomids captured in peridomestic environments in a formerly-endemic area of Chagas disease in Southeast ..
- Impact of culture conditions, culture media volumes, and glucose content on metabolic properties of renal epithelial cell cultures. Are renal cells in tissue culture hypoxic?G Gstraunthaler
Institute of Physiology, University of Innsbruck, Austria
Cell Physiol Biochem 9:150-72. 1999..Thus, changes in nutrient supply and oxygenation of renal epithelial cell cultures by altered culture media volumes dramatically influence metabolic rates and levels of enzyme activities, respectively...
- Mapping the distribution of the interstitial telomeric (TTAGGG)n sequences in eight species of Brazilian marsupials (Didelphidae) by FISH and the correlation with constitutive heterochromatin. Do ITS represent evidence for fusion events in American marsupJ M Pagnozzi
Departamento de Biologia, Instituto de Biociencias, Universidade de Sao Paulo, Sao Paulo, Brazil
Cytogenet Genome Res 98:278-84. 2002..We suggest that the interstitial (TTAGGG)(n) sequences are associated with satellite DNA and do not necessarily arise through chromosomal rearrangements...
- New DNA data from a transthyretin nuclear intron suggest an Oligocene to Miocene diversification of living South America opossums (Marsupialia: Didelphidae)Cynthia Steiner
Laboratoire de Paléontologie, Phylogénie et Paléobiologie, Institut des Sciences de l Evolution UMR 5554 CNRS, Universite Montpellier II, Montpellier, France
Mol Phylogenet Evol 35:363-79. 2005..Nuclear markers supported the monophyly of medium and large-sized opossums Metachirus+(Chironectes, Lutreolina, Didelphis, Philander), and the paraphyly of mouse-sized opossums, with the ..
- Exceptionally preserved North American Paleogene metatherians: adaptations and discovery of a major gap in the opossum fossil recordMarcelo Sánchez-Villagra
Palaeontologisches Institut und Museum, Karl Schmid Strasse 4, 8006 Zurich, Switzerland
Biol Lett 3:318-22. 2007..with a fossil record extending from the Cretaceous to the Miocene, has traditionally been allied with opossums (Didelphidae) based on fragmentary material, mainly dentitions...
- Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase reduce receptor-mediated endocytosis in opossum kidney cellsJames E Sidaway
AstraZeneca, Safety Assessment, 23S37 69, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK
J Am Soc Nephrol 15:2258-65. 2004..These data establish the possibility in principle that inhibition of HMG-CoA reductase by statins in proximal tubule cells may reduce tubular protein reabsorption...
- Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporterM F Pfister
Institute of, University of Zurich, CH 8057 Zurich, Switzerland
Proc Natl Acad Sci U S A 95:1909-14. 1998....
- Endosomal alkalinization reduces Jmax and Km of albumin receptor-mediated endocytosis in OK cellsM Gekle
Department of Physiology, , Germany
Am J Physiol 268:F899-906. 1995..Endosomal alkalinization disturbs intracellular ligand handling and receptor trafficking, leading to a reduction of endocytotic capacity and affinity...
- Murine typhus: an unrecognized suburban vectorborne diseaseRachel Civen
Acute Communicable Disease Control Program, Los Angeles County Public Health Department, Los Angeles, California 90012, USA
Clin Infect Dis 46:913-8. 2008..Contrary to the classic rat-flea-rat cycle, the most important reservoirs of infection in these areas are opossums and cats. The cat flea, Ctenocephalides felis, has been identified as the principal vector...
- Geographic association of Rickettsia felis-infected opossums with human murine typhus, TexasArdys Boostrom
Corpus Christi Nueces County Department of Public Health, Corpus Christi, Texas, USA
Emerg Infect Dis 8:549-54. 2002..R. felis has been associated with opossums and their fleas in Texas and California. Because R...
- Conservation of Dnmt1o cytosine methyltransferase in the marsupial Monodelphis domesticaFeng Ding
Genesis 36:209-13. 2003..Thus, an essential component of imprinting in eutherian mammals is found in a marsupial species, suggesting that marsupials and eutherian mammals imprint their genes with the same methylation-dependent mechanism...
- Effect of ezetimibe on plasma cholesterol levels, cholesterol absorption, and secretion of biliary cholesterol in laboratory opossums with high and low responses to dietary cholesterolJeannie Chan
Department of Genetics and Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
Metabolism 57:1645-54. 2008Partially inbred lines of laboratory opossums differ in plasma low-density lipoprotein cholesterol concentration and cholesterol absorption on a high-cholesterol diet...
- Effect of peroxynitrite on motor function of the opossum esophagusA Uc
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 55242, USA
Dig Dis Sci 46:30-7. 2001..It is possible that some of the esophageal motor dysfunction seen with esophagitis may be related to the formation of ONOO-...
- Effect of endotoxin on opossum oesophageal motor functionH Park
Department of Internal Medicine, University of Iowa, College of Medicine and VA Medical Center, Iowa City, USA
Neurogastroenterol Motil 12:215-21. 2000..The increase in plasma nitrite/nitrate was attenuated by AG. These studies support the hypothesis that endotoxin modulates oesophageal motor function by increasing NO production and suggest that this results from the induction of iNOS...
- Cholesterol absorption and hepatic acyl-coenzyme A:cholesterol acyltransferase activity play major roles in lipemic response to dietary cholesterol and fat in laboratory opossumsRampratap S Kushwaha
Department of Physiology and Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX, USA
Metabolism 53:817-22. 2004Partially inbred lines of laboratory opossums differ considerably in their low-density lipoprotein (LDL) cholesterol responses to dietary cholesterol and fat...
- The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cellsYuanli Li
Dept of Internal Medicine, Section of Nephrology, Yale Univ School of Medicine, 300 Cedar St, TAC S255, P O Box 208029, New Haven, CT 06520 8029, USA
Am J Physiol Cell Physiol 295:C529-37. 2008....
- Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epitheliumHiroki Inoue
Department of Biological Science, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
Biol Pharm Bull 26:148-55. 2003..These results suggest that CHP2 functions in the absorptive epithelium for the intestine with NHE(s)...
- Na+-independent transporters, LAT-2 and b0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell linesP Gomes
Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 319 Porto, Portugal
J Membr Biol 186:63-80. 2002..LAT-2 was found equally important at the apical and basolateral membranes, whereas system b0,+ had a predominant distribution in apical membranes...
- Regulation of the renal type IIa Na/Pi cotransporter by cGMPD Bacic
Institutes of Anatomy and Physiology, University of Zurich, Zurich, Switzerland
Pflugers Arch 443:306-13. 2001..Our findings document that cGMP-mediated regulation (ANP and NO) of type IIa Na/Pi-cotransporters also takes place via internalization of the transporter protein...
- Intracellular Na+ regulates dopamine and angiotensin II receptors availability at the plasma membrane and their cellular responses in renal epitheliaRiad Efendiev
College of Pharmacy, University of Houston, Houston, Texas 77204, USA
J Biol Chem 278:28719-26. 2003..Thus, one or more proteins may act as an intracellular Na+ concentration sensor and play a major regulatory role on the effect of hormones that regulate proximal tubule Na+ reabsorption...
- Na(+)/H(+) exchanger 3 is in large complexes in the center of the apical surface of proximal tubule-derived OK cellsS Akhter
Department of Medicine, Gastrointestinal Division, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2195, USA
Am J Physiol Cell Physiol 283:C927-40. 2002..In the BB fraction, NHE3 is largely in the detergent-insoluble fraction in lipid rafts and/or in large heterogenous complexes ranging from approximately 400 to approximately 900 kDa...
- NHE3 serves as a molecular tool for cAMP-mediated regulation of receptor-mediated endocytosisMichael Gekle
Physiologisches Institut, University of Wurzburg, 97070 Wurzburg, Germany
Am J Physiol Renal Physiol 283:F549-58. 2002..NHE3 transfection into deficient cells restores RME and the effects of cAMP. Thus our data show that NHE3 is important for cAMP sensitivity of clathrin-dependent RME...
- Interaction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphateMikiko Ito
Department of Nutrition, Tokushima University, School of Medicine, Kuramoto cho 3 18 15, Tokushima City 770 8503, Japan
Biochem J 377:607-16. 2004..In conclusion, the present study indicates that PEX19 may be actively involved in controlling the internalization and trafficking of the Na/P(i) IIa co-transporter...
- Insulin activates Na(+)/H(+) exchanger 3: biphasic response and glucocorticoid dependenceJelena Klisic
Department of Physiology, University of Zurich Irchel, CH 8057 Zurich, Switzerland
Am J Physiol Renal Physiol 283:F532-9. 2002....
- Glucagon acutely inhibits but chronically activates Na(+)/H(+) antiporter 3 activity in OKP cellsMorimasa Amemiya
Department of Internal Medicine, Division of Nephrology, Jichi Medical School, Tochigi, Japan
Exp Nephrol 10:26-33. 2002..In the present study, we examined the direct effect of glucagon on the opossum kidney P (OKP) cell Na(+)/H(+) antiporter, encoded by NHE3...
- Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cellsAdriana C C Girardi
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8029, USA
Am J Physiol Cell Physiol 287:C1238-45. 2004..We conclude that DPPIV plays an unexpected role in modulating Na+/H+ exchange mediated by NHE3 in proximal tubule cells...
- Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondriaChristopher L Brett
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Am J Physiol Cell Physiol 282:C1031-41. 2002..These results suggest that, like its homologs in yeast and plants, NHE6 is an endosomal Na(+)/H(+) exchanger that may regulate intravesicular pH and volume and contribute to lysosomal biogenesis...
- Stimulation of NHE3 in OKP cells by an autocrine mechanismMorimasa Amemiya
Department of Internal Medicine, Division of Nephrology, Jichi Omiya Medical Center, Jichi Medical School, Saitama shi, Saitama Ken, Japan
Nephron Exp Nephrol 96:e23-30. 2004..Chronic hypokalemia increases NHE3 activity in OKP cells. The aim of the present study was to determine whether an autocrine mechanism is involved in this activation...
- Na+/H+ exchanger NHE3 activity and trafficking are lipid Raft-dependentRakhilya Murtazina
Departments of Physiology and Medicine, Division of Gastroenterology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
J Biol Chem 281:17845-55. 2006....
- Quaternary structure and apical membrane sorting of the mammalian NaSi-1 sulfate transporter in renal cell linesRalf R Regeer
Department of Physiology and Pharmacology, School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia
Int J Biochem Cell Biol 39:2240-51. 2007..Our data demonstrates that NaSi-1 forms a dimeric protein which is glycosylated at N591, whose sorting to the apical membrane in renal epithelial cells is brefeldin A-sensitive and independent of lipid rafts or glycosylation...
- Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidneyMohammad Saifur Rohman
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School, Kobe, Japan
Kidney Int 67:1410-9. 2005..However, little is known about the molecular cascade from the clock gene oscillators to cellular function...
- Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosisI Alexandru Bobulescu
Univ of Texas Southwestern Medical Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
Am J Physiol Renal Physiol 289:F685-91. 2005....
- Parathyroid hormone regulation of NA+,K+-ATPase requires the PDZ 1 domain of sodium hydrogen exchanger regulatory factor-1 in opossum kidney cellsSyed Jalal Khundmiri
Department of Medicine, University of Louisville, Kidney Disease Program, Louisville, KY 40202, USA
J Am Soc Nephrol 16:2598-607. 2005..These results demonstrate that NHERF-1 is necessary for PTH-mediated inhibition of Na+,K+-ATPase activity and that the inhibition is mediated through the PDZ1, not PDZ2, domain...
- Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageingE Silva
Faculty of Medicine, Institute of Pharmacology and Therapeutics, 4200 319, Porto, Portugal
J Membr Biol 212:163-75. 2006..Ouabain (100 nM: ) increased alpha(1)-subunit, but not beta(1)-subunit, Na(+)/K(+)-ATPase expression in aged cells only. These cells constitute an interesting model for the study of renal epithelial cell ageing...
- Membrane curvature alters the activation kinetics of the epithelial Na+/H+ exchanger, NHE3R Todd Alexander
Department of Pediatrics, Program in Cell Biology, and Program in Computational Biology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
J Biol Chem 282:7376-84. 2007..We conclude that NHE3 exists in multiple states and that different physiological parameters control the transitions between them...
- The role played by endocytosis in albumin-induced secretion of TGF-beta1 by proximal tubular epithelial cellsRamaswamy Diwakar
South West Thames Institute for Renal Research, St Helier Hospital, Carshalton, Surrey, United Kingdom
Am J Physiol Renal Physiol 292:F1464-70. 2007..Moreover, we found that albumin-induced TGF-beta(1) secretion by PTECs is not dependent on its interaction with megalin...
- Characterization of the regulation of renal Na+/H+ exchanger NHE3 by insulinDaniel G Fuster
Department of Internal Medicine, University of Texas Southwestern Medical Ctr, Dallas, TX 75390 8856, USA
Am J Physiol Renal Physiol 292:F577-85. 2007..In summary, insulin stimulates NHE3 acutely via yet undefined pathways and mechanisms. The chronic effect of insulin is mediated by the classic PI3K-SGK1 route...
- A human orphan calcitonin receptor-like structureB Fluhmann
Department of Orthopaedic Surgery, University of Zurich, Switzerland
Biochem Biophys Res Commun 206:341-7. 1995..The receptor-like protein whose ligand remains to be discovered belongs to the family of receptors of calcitonin, parathyroid hormone, secretin, vasointestinal peptide and pituitary adenylate cyclase-activating polypeptide...
- Regulation of Na+/H+ exchanger-NHE3 by angiotensin-II in OKP cellsLiping Xu
Department of Pediatrics and Physiology, Steele Children s Research Center, University of Arizona Health Sciences Center, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
Biochim Biophys Acta 1758:519-26. 2006..We conclude that a transcriptional mechanism is at least partially responsible for the chronic effects of A-II treatment on renal NHE3 activity...
- Insulin treatment enhances AT1 receptor function in OK cellsAnees Ahmad Banday
Heart and Kidney Institute, College of Pharmacy, University of Houston, TX 77204, USA
Am J Physiol Renal Physiol 288:F1213-9. 2005....
- Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubuleZhiying Zou
Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT 06520 8029, USA
J Biol Chem 279:34302-10. 2004..We postulate that the enzymatic processing of megalin represents part of a novel ligand-dependent signaling pathway in the proximal tubule that links receptor-mediated endocytosis with cell signaling...
- Ouabain-insensitive acidification by dopamine in renal OK cells: primary control of the Na(+)/H(+) exchangerP Gomes
Faculty of Medicine, Institute of Pharmacology and Therapeutics, 4200 Porto, Portugal
Am J Physiol Regul Integr Comp Physiol 281:R10-8. 2001....
- Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sitesHetal S Kocinsky
Department of Pediatrics, Yale School of Medicine, New Haven, CT 06520 8029, USA
Am J Physiol Renal Physiol 289:F249-58. 2005..In conclusion, we successfully generated phosphospecific antibodies that should be useful to assess the phosphorylation of endogenous NHE3 at its two PKA consensus sites under a variety of physiological conditions in vitro and in vivo...
- Novel regulatory function for NHERF-1 in Npt2a transcriptionSyed Jalal Khundmiri
Department of Medicine, Univ of Louisville, Kidney Disease Program, 570 S Preston St, Suite 102, Louisville, KY 40202, USA
Am J Physiol Renal Physiol 294:F840-9. 2008..Our data demonstrate for the first time that NHERF-1 regulates Npt2a transcription and membrane insertion...
- Distinct signalling cascades downstream to Gsalpha coupled dopamine D1-like NHE3 inhibition in rat and opossum renal epithelial cellsRui Pedrosa
Institute of Pharmacology Therapeutics, Faculty of Medicine, Porto, Portugal
Cell Physiol Biochem 14:91-100. 2004..By contrast, the D1-mediated inhibition of NHE3 in renal opossum cells involves a peculiar mechanism with AC-PKA and PLC-PKC pathways...
- ET(B) receptor activation causes exocytic insertion of NHE3 in OKP cellsY Peng
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
Am J Physiol Renal Physiol 280:F34-42. 2001..These studies demonstrate that ET-1 induces net trafficking of NHE3 to the apical membrane that is mediated by enhanced exocytic insertion and is required for increased NHE3 activity...
- The use of High Performance Thin-Layer Chromatography to determine the role of membrane lipid composition in bile salt-induced kidney cell damageWinston A Morgan
School of Health and Bioscience, University of East London, Romford Road, London E15 4LZ, United Kingdom
J Pharmacol Toxicol Methods 57:70-3. 2008..In obstructive liver disease bile salts are known to accumulate in and damage specific kidney cells. High Performance Thin-Layer Chromatography (HPTLC) was used to determine the membrane lipid composition of a range of kidney cells...
- Lysophosphatidic acid induces exocytic trafficking of Na(+)/H(+) exchanger 3 by E3KARP-dependent activation of phospholipase CJung Woong Choi
Department of Physiology and Medicine, Gastrointestinal Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Biochim Biophys Acta 1683:59-68. 2004....
- Effect of renal lipid accumulation on proximal tubule Na+/H+ exchange and ammonium secretionI Alexandru Bobulescu
Dept of Internal Medicine, Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
Am J Physiol Renal Physiol 294:F1315-22. 2008..These findings suggest that renal steatosis decreases ammonium secretion in the proximal tubule, in part by reducing NHE3 activity and by impairing the regulation of NHE3 by specific agonists...
- Sarcocystis neurona (Protozoa: Apicomplexa): description of oocysts, sporocysts, sporozoites, excystation, and early developmentDavid S Lindsay
Department of Biomedical Sciences and Pathobiology, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, 24061 0342, USA
J Parasitol 90:461-5. 2004..Sporozoites contained 2-4 electron-dense rhoptries and other organelles typical of coccidian zoites. Sporozoites entered host cells in culture and underwent schizogony within 3 days...
- Role of cAMP-PKA-PLC signaling cascade on dopamine-induced PKC-mediated inhibition of renal Na(+)-K(+)-ATPase activityPedro Gomes
Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 Porto, Portugal
Am J Physiol Renal Physiol 282:F1084-96. 2002....
- Cofilin interacts with ClC-5 and regulates albumin uptake in proximal tubule cell linesDeanne H Hryciw
Department of Physiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Biol Chem 278:40169-76. 2003..This study identifies a novel interaction between the C-terminal tail of ClC-5 and cofilin, an actin-associated protein that is crucial in the regulation of albumin uptake by the proximal tubule...
- The rBAT gene is responsible for L-cystine uptake via the b0,(+)-like amino acid transport system in a "renal proximal tubular" cell line (OK cells)C Mora
Department of Biochemistry and Molecular Biology, Faculty of Biology, Universitat de Barcelona, Spain
J Biol Chem 271:10569-76. 1996..These results demonstrate that rBAT is functionally related to the L-cystine uptake via system b0,(+)-like in the apical pole of the renal OK cell line...
- Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cellsEleanor DeLand Lederer
Louisville Veterans Administration Medical Center, Louisville, Kentucky, USA
J Am Soc Nephrol 14:1711-9. 2003..These experiments also suggest that the mechanism for retrieval of NaPi IIa transporters from the apical membrane in response to cAMP does not require NHERF...
- Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cellsN M Al-Rasheed
Department of Cell Physiology and Pharmacology, Faculty of Medicine and Biological Sciences, University of Leicester, Medical Sciences Building, University Road, Leicester LE1 9HN, United Kingdom
Diabetologia 47:987-97. 2004..We therefore investigated the ability of C-peptide to stimulate intracellular signalling pathways in kidney proximal tubular cells, the altered activation of which may possibly be related to the development of diabetic nephropathy...
- Regulation of the procine 1,25-dihydroxyvitamin D3-24-hydroxylase (CYP24) by 1,25-dihydroxyvitamin D3 and parathyroid hormone in AOK-B50 cellsC Zierold
College of Agricultural and Life Sciences, Department of Biochemistry, University of Wisconsin Madison, 53706, USA
Arch Biochem Biophys 381:323-7. 2000..In view of the above findings we concluded that AOK-B50 cells are a suitable model for further studying the mechanism of action of PTH on 24-hydroxylase mRNA...
- Cytotoxicity of peroxisome proliferator-activated receptor alpha and gamma agonists in renal proximal tubular cell linesHector Giral
Laboratory of Molecular Toxicology, University of Zaragoza, E50013 Zaragoza, Spain
Toxicol In Vitro 21:1066-76. 2007..With these methods, no signs of apoptosis were observed, which suggests a direct necrosis of the compounds on these renal proximal tubular cell lines...
- Short-term regulation of basolateral organic anion uptake in proximal tubular OK cells: EGF acts via MAPK, PLA(2), and COX1Christoph Sauvant
Physiologisches Institut der Universität Würzburg, Wurzburg, Germany
J Am Soc Nephrol 13:1981-91. 2002..Subsequently, arachidonic acid is metabolized to prostaglandins via COX1, which then mediate EGF-induced stimulation of basolateral organic anion uptake rate...
- Unique uptake and efflux systems of inorganic phosphate in osteoclast-like cellsMikiko Ito
Department of Molecular Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Kuramoto cho 3 18 15, Tokushima City 770 8503, Japan
Am J Physiol Cell Physiol 292:C526-34. 2007..These results suggest that osteoclast-like cells have a unique P(i) uptake/efflux system and can prevent P(i) accumulation within osteoclast hemivacuoles...
- Bimodal acute effects of A1 adenosine receptor activation on Na+/H+ exchanger 3 in opossum kidney cellsFrancesca Di Sole
Department of Physiology and Pathophysiology, Division of Vegetative Physiology and Pathophysiology, Georg August University of Goettingen, Humboldtallee 23, D 37073 Goettingen, Germany
J Am Soc Nephrol 14:1720-30. 2003....
- Expression and function of sodium transporters in two opossum kidney cell clonal sublinesPedro Gomes
Institute of Pharmacology and Therapeutics, Faculty of Medicine, 4200 319 Porto, Portugal
Am J Physiol Renal Physiol 283:F73-85. 2002..It is suggested that OK(LC) and OK(HC) cells constitute an interesting cell model for the study of renal epithelial physiology and pathophysiology, namely, hypertension...
- C-peptide signals via Galpha i to protect against TNF-alpha-mediated apoptosis of opossum kidney proximal tubular cellsNawal M Al-Rasheed
Department of Nephrology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
J Am Soc Nephrol 17:986-95. 2006..The data further support the concept of C-peptide as a peptide hormone in its own right and suggest a potential therapeutic role for C-peptide...
- INDUCTION OF MELANOMA WITH UV-ARonald Ley; Fiscal Year: 2000..Groups of opossums will be exposed to graded doses of UV-A three times per week for up to 104 wee Animals will be monitored to ..
- FUNCTION OF THE PINEAL COMPLEXCHARLES RALPH; Fiscal Year: 1980..temperature and metabolism, using ectotherms (lizards, alligators, snakes) and endotherms (squirrels, armadillos, opossums)...
- Internal environment of the developing brainNorman Saunders; Fiscal Year: 2006..The studies will be in S. American opossums (Monodelphis domestica); they are born at a very early stage of brain development (equivalent to 13 day fetal ..
- LIFE-SHORTENING EFFECTS OF ENVIRONMENTAL UV EXPOSURERonald Ley; Fiscal Year: 1991..that photoreactivating treatment also partially abrogates the life-shortening effect of chronic UV exposure in opossums. We wish to explore in detail the life-shortening effect of chronic UV exposure...
- Stem cell-mediated delivery of neurotrophic factors for treatment of glaucomaDonald S Sakaguchi; Fiscal Year: 2010..Furthermore, these cells can survive in the environment of the eye and have the ability to integrate within the inner retina to serve as delivery vehicles for therapeutic proteins. ..
- HOST FACTORS MEDIATE INVASION BY CAMPYLOBACTER JEJUNILINDA MANSFIELD; Fiscal Year: 2002..jejuni invasion is facilitated due to a direct effect of some secreted/excreted product of the worms, and 4) Determine what host cell genes are differentially expressed during C. jejuni invasion. ..
- Matrilysin in Lung Epithelial Cell MigrationJohn McGuire; Fiscal Year: 2007..McGuire will have the opportunity to develop experience and expertise in the application of basic techniques and approaches in molecular biology, cell biology, and protein biochemistry to fundamental questions in pulmonary biology. ..
- Generation of Genetically Attenuated RickettsiaeAbdu Azad; Fiscal Year: 2009..The underlying hypothesis tested is whether recombinant strains with altered genes maintain their immunogenicity within mammals and provide cross protection to subsequent challenge with virulent strains. ..
- Mechanistic Studies at the Host-pathogen InterfaceDavid McMurray; Fiscal Year: 2007..unreadable] [unreadable]..
- Effects of Myostatin Deficiency on Bone StrengthMark Hamrick; Fiscal Year: 2007..abstract_text> ..
- SPARING AND EXERCISE TRAINING PROMOTE RECOVERY IN SCIMichele Basso; Fiscal Year: 2006..abstract_text> ..
- Role of MRP2 and MRP4 in renal organic anion excretionRYAN PELIS; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Murine Typhus: Vector Biology & TransmissionAbdu Azad; Fiscal Year: 2007..typhi and ELB isolates[unreadable] obtained from opossums and humans...
- Improved Molecular Imaging with SPECTMathew Thakur; Fiscal Year: 2006..It also takes advantage of adapting existing clinical SPECT machines, rather than developing a dedicated small animal imaging system, which makes it much less expensive and more widely available. [unreadable] [unreadable]..
- Polymicrobial Associations in Inflammatory Bowel DiseaseGERALD DUHAMEL; Fiscal Year: 2006..abstract_text> ..
- IMMUNE PROTECTION AGAINST MNU-INDUCTED DIGITAL DEFECTSMARY PRATER; Fiscal Year: 2006..This research under the guidance of Drs. Steven Holladay and Eric Wong at Virginia Tech...
- Natural ligands for 2 endothelin-like orphan receptorsRainer Reinscheid; Fiscal Year: 2004..Identification of the natural ligands will enable us to study the physiological functions of these two orphan GPCRs under normal and pathological conditions. ..
- Mechanistic Role of Peroxynitrite in Gallbladder DiseaseJOSEPH CULLEN; Fiscal Year: 2004..In addition, it is expected that the results will fundamentally advance the field of free radical biology and gallbladder physiology. ..
- Agmatine Mediated Arrest of ProliferationJoseph Satriano; Fiscal Year: 2003..UCSD has established itself as a leading academic institution and thus provides an excellent environment for the exchange of ideas and techniques essential for the growth of the PI's career. ..
- DIETARY DEFICIENCIES AND TUBERCULOSIS VACCINE EFFICACYDavid McMurray; Fiscal Year: 2009..abstract_text> ..
- Mechanism/regulation of human intestinal thiamin uptakeHAMID SAID; Fiscal Year: 2008..This should ultimately assist us in the designing of effective strategies to optimize thiamin body homeostasis in conditions associated with thiamin deficiency and sub-optimal levels. ..
- Physiological Functions of Neuropeptide SRainer Reinscheid; Fiscal Year: 2009..We will study the pharmacology of the mutant receptor isoforms which may help to understand the physiological consequences of the mutation in human airway tissue. ..
- Gene Expression Arrays for the Laboratory OpossumPAUL SAMOLLOW; Fiscal Year: 2009..An explicit objective of the proposed study is to make these cDNA libraries, gene arrays, and database resources fully accessible to the research community. ..
- Ets-1 Expression in Squamous Cells of the Oral CavityLEE GARRETT SINHA; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Genotypic and Phenotypic Analysis of West Nile virus, Yucatan Peninsula of MexicoBradley Blitvich; Fiscal Year: 2008..This information will help determine why there has not been an epidemic of WNV in the YP, and will identify risk factors associated with WNV disease. [unreadable] [unreadable] [unreadable]..
- PET for Molecular Imaging of Small AnimalsMathew Thakur; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- PET Imaging of Breast Cancer Using Oncogene ExpressionMathew Thakur; Fiscal Year: 2008..abstract_text> ..
- C elegans:a model to study intestinal water-soluble vitamins transport in vivoHAMID SAID; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- OPOSSUM MODEL FOR THE HIGH & LOW RESPONSES TO DIETRAMPRATAP KUSHWAHA; Fiscal Year: 2004..Partially inbred strains of opossums exhibit individual differences in very low (VLDL) and low (LDL) density lipoprotein cholesterol concentrations in ..
- Tool to Define the Antiproliferative Effects of AgmatineJoseph Satriano; Fiscal Year: 2006..These pathways will have particular application to diabetes and IRI in kidney, models we plan to pursue. [unreadable] [unreadable]..
- Oxidative Stress Attenuates Na+:Ca+ Exchanger ActivityMENJOR UNLAP; Fiscal Year: 2005..We will examine exchanger nitration, phosphorylation, and translocation under oxidative stress conditions and determine how they relate to the attenuation of exchanger activity. ..
- BIOLOGY AND IMMUNOLOGY OF MALARIA PARASITE LIVER-STAGESAbdu Azad; Fiscal Year: 2005..falciparum EE-stages. Finally, we will define the contribution of P. yoelii liver-stage gene products in protective immunity via DNA immunizations. ..
- GENETICS OF THYROID HORMONES IN MEXICAN AMERICANSPAUL SAMOLLOW; Fiscal Year: 2001..QTL linkage analyses will be performed to test for linkage between genes that influence thyroid hormone variation and the two sets of genetic markers, i.e., candidate genes and STR markers. ..
- Carcinogenesis: Effects of Diet Deficient in Methyl DonorsShi Huang; Fiscal Year: 2007..The new understanding that will emerge from these studies will help clarify the role of nutrient metabolism in carcinogenesis. The results may have important public health implications. ..
- Modulation of Diabetic Kidney Growth/ HypertrophyJoseph Satriano; Fiscal Year: 2007..unreadable] [unreadable]..
- Mechanisms of Dicumarol-Induced CytotoxicityJOSEPH CULLEN; Fiscal Year: 2007..pancreatic cancer cells. [unreadable] [unreadable] [unreadable]..
- IMAGING THROMBOEMBOLISM WITH FIBRIN AVID TC-99M-PEPTIDEMathew Thakur; Fiscal Year: 2002..Because there are no agents currently available than can scintigraphically provide "hot spot" images of old (24 hr or older) clots and PE, the commercial potential for this agent is very high. ..