Genomes and Genes
Summary: Carnivores of genus Mustela of the family MUSTELIDAE. The European mink, which has white upper and lower lips, was widely trapped for commercial purposes and is classified as endangered. The American mink, lacking a white upper lip, is farmed commercially.
Publications265 found, 100 shown here
- Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradationT Ebisawa
Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, and Research for the Future Program, the Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
J Biol Chem 276:12477-80. 2001..These results thus reveal a novel function of Smad7, i.e. induction of degradation of TbetaR-I through recruitment of an E3 ligase to the receptor...
- Emergence of a new swine H3N2 and pandemic (H1N1) 2009 influenza A virus reassortant in two Canadian animal populations, mink and swineDonald Tremblay
Service de diagnostic, Universite de Montreal, 3200 rue Sicotte, St Hyacinthe, Quebec, Canada J2S 7C6
J Clin Microbiol 49:4386-90. 2011..Simultaneously, a similar virus was also detected in Canadian mink based on partial viral genome sequencing...
- The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2I Reynisdottir
Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Genes Dev 11:492-503. 1997..These properties allow p15 and p27 to coordinately inhibit cdk4 and cdk2...
- Reproductive and developmental toxicity of a pentabrominated diphenyl ether mixture, DE-71, to ranch mink (Mustela vison) and hazard assessment for wild mink in the Great Lakes regionSi Zhang
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
Toxicol Sci 110:107-16. 2009..of rodents; however, these studies do not necessarily predict toxicity to highly exposed top predators, such as mink (Mustela vison). Here we assessed the effects of environmentally relevant doses (0, 0.1, 0.5, and 2...
- Bayesian analysis of hybridization and introgression between the endangered european mink (Mustela lutreola) and the polecat (Mustela putorius)M T Cabria
Departamento de Zoología y BCA, Facultad de Farmacia, Universidad del Pais Vasco UPV EHU, Vitoria Gasteiz, Spain
Mol Ecol 20:1176-90. 2011..hybridization and genetic introgression between two sympatric sister species of mustelids, the endangered European mink (Mustela lutreola) and the more abundant polecat (M. putorius)...
- Detection of a novel astrovirus in brain tissue of mink suffering from shaking mink syndrome by use of viral metagenomicsAnne Lie Blomström
Department of Biomedical Sciences and Veterinary Public Health, Section of Virology, Swedish University of Agricultural Sciences, Box 7036, S 750 07 Uppsala, Sweden
J Clin Microbiol 48:4392-6. 2010In 2000, farmed mink kits in Denmark were affected by a neurological disorder. The characteristic clinical signs included shaking, staggering gait, and ataxia...
- Monitoring blood glucose levels in female mink during the reproductive cycle: 2. Effects of short-term fish oil, chromium picolinate, and acetylsalicylic acid supplementation during late lactationAmber M J Hynes
Nova Scotia Agricultural College, Department of Plant and Animal Sciences and Canadian Centre for Fur Animal Research, PO Box 550, Truro, Nova Scotia B2N 5E3
Can J Vet Res 71:249-55. 2007b>Mink nursing sickness is a metabolic disorder characterized by hyperglycemia that is similar to the metabolic syndrome associated with type 2, or non-insulin-dependent, diabetes mellitus...
- Environmental enrichment reduces signs of boredom in caged minkRebecca K Meagher
Animal and Poultry Science Department, University of Guelph, Guelph, Ontario, Canada
PLoS ONE 7:e49180. 2012..We tested the hypotheses that mink, a model carnivore, experience more boredom, depression-like apathy, or anhedonia in non-enriched (NE) cages than ..
- The capsid proteins of Aleutian mink disease virus activate caspases and are specifically cleaved during infectionFang Cheng
Department of Microbiology, Molecular Genetics and Immunology, Mail Stop 3029, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
J Virol 84:2687-96. 2010Aleutian mink disease virus (AMDV) is currently the only known member of the genus Amdovirus in the family Parvoviridae. It is the etiological agent of Aleutian disease of mink...
- Mercury levels in mink (Mustela vison) and river otter (Lontra canadensis) from northeastern North AmericaDavid E Yates
BioDiversity Research Institute, 19 Flaggy Meadow Road, Gorham ME 04038, USA
Ecotoxicology 14:263-74. 2005..Here we examine regional variation in total mercury (Hg) in brain, liver, and fur from otter and mink collected across New York, New England, and Nova Scotia...
- Hybridization between escaped domestic and wild American mink (Neovison vison)A G Kidd
Biology Department, Laurentian University, Sudbury, ON, Canada
Mol Ecol 18:1175-86. 2009..Wild American mink (Neovison vison) populations may be threatened not only by competition for resources with domestic mink originating ..
- TGF beta signals through a heteromeric protein kinase receptor complexJ L Wrana
Cell Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021
Cell 71:1003-14. 1992..This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors...
- Analysis of experimental mink enteritis virus infection in mink: in situ hybridization, serology, and histopathologyA Uttenthal
Department of Veterinary Virology and Immunology, Royal Veterinary and Agricultural University, Frederiksberg C, Denmark
J Virol 64:2768-79. 1990Strand-specific hybridization probes were used in in situ hybridization studies to localize cells containing mink enteritis virus (MEV) virion DNA or MEV replicative-form DNA and mRNA...
- Mink lung epithelial cells: unique cell line that supports influenza A and B virus replicationS Schultz-Cherry
Southeast Poultry Research Laboratory, Agricultural Research Service, U S Department of Agriculture, Athens, Georgia 30605, USA
J Clin Microbiol 36:3718-20. 1998We have demonstrated for the first time that a mink lung epithelial cell line (Mv1Lu) supports the replication of influenza A and B viruses, including the recently isolated H5N1 avian and human Hong Kong strains, to titers comparable to ..
- Polyamines are implicated in the emergence of the embryo from obligate diapausePavine L C Lefèvre
Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 rue Sicotte, St Hyacinthe, Quebec, Canada J2S 7C6
Endocrinology 152:1627-39. 2011..In many carnivores, such as the mink (Neovison vison), obligate diapause characterizes each gestation...
- A survey of Aleutian mink disease virus infection of feral American mink in Nova ScotiaA Hossain Farid
Nova Scotia Agricultural College, Department of Plant and Animal Sciences, Truro, Nova Scotia B2N 5E3
Can Vet J 51:75-7. 2010Spleen samples from 14 mink that were trapped in 4 counties of Nova Scotia were tested for the presence of the Aleutian mink disease virus (AMDV) by polymerase chain reaction...
- Rapid development of fasting-induced hepatic lipidosis in the American mink (Neovison vison): effects of food deprivation and re-alimentation on body fat depots, tissue fatty acid profiles, hematology and endocrinologyKirsti Rouvinen-Watt
Department of Plant and Animal Sciences, Nova Scotia Agricultural College, Truro, NS, Canada
Lipids 45:111-28. 2010Hepatic lipidosis is a common pathological finding in the American mink (Neovison vison) and can be caused by nutritional imbalance due to obesity or rapid body weight loss...
- Delay in onset of prion disease for the HY strain of transmissible mink encephalopathy as a result of prior peripheral inoculation with the replication-deficient DY strainJason C Bartz
Department of Medical Microbiology and Immunology, Creighton University, Omaha, NE 68178, USA
J Gen Virol 85:265-73. 2004We report that the replication-deficient DY strain of transmissible mink encephalopathy (TME) can delay disease caused by the pathogenic HY TME strain...
- Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptorsS Souchelnytskyi
Ludwig Institute for Cancer Research, Biomedical Center, S 751 24 Uppsala, Sweden
J Biol Chem 273:25364-70. 1998..Our results are consistent with the possibility that the C-domain of antagonistic Smads is an effector domain whereas the N-domain may confer specificity for distinct signaling pathways...
- The escape of the mink embryo from obligate diapauseJoëlle A Desmarais
Centre de Recherche en Reproduction Animale, Faculte de Medecine Veterinaire, Universite de Montreal, CP 5000, St Hyacinthe, Quebec, Canada J2S 7C6
Biol Reprod 70:662-70. 2004The obligate embryonic diapause that characterizes gestation in mink engenders a developmental arrest at the blastocyst stage...
- Alleles A and B of non-structural protein 1 of avian influenza A viruses differentially inhibit beta interferon production in human and mink lung cellsMuhammad Munir
Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden
J Gen Virol 92:2111-21. 2011..Apart from dsRNA signalling, differences were observed in the expression pattern of NS1 in transfected human and mink lung cells...
- Growth of respiratory syncytial virus in mink lung epithelial cellsL R Yeolekar
National Institute of Virology ICMR, Pune, India
Indian J Med Res 116:255-7. 2002b>Mink lung epithelial cells (Mv-1-Lu) were tested for their ability to support the growth and serial passage of respiratory syncytial virus (RSV) in vitro...
- Recurrent perseveration correlates with abnormal repetitive locomotion in adult mink but is not reduced by environmental enrichmentJamie A Dallaire
University of Guelph, Department of Animal and Poultry Science, 50 Stone Road East, Building 70, Guelph, Ontario N1G 2W1, Canada
Behav Brain Res 224:213-22. 2011..the presence/absence of environmental enrichment, and two types of behavioural disinhibition in farmed American mink, Neovison vison...
- Mercury and stable isotopes of carbon and nitrogen in minkJames L Lake
Atlantic Ecology Division National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Narragansett, Rhode Island 02882, USA
Environ Toxicol Chem 26:2611-9. 2007Total Hg concentrations and values of stable isotopes (delta(15)N, delta(13)C) in tissues of mink (Mustela vison) captured in Rhode Island (USA) during winters of 1999 to 2004 were statistically distinct based on location...
- Transmissible mink encephalopathy - review of the etiology of a rare prion diseasePaweł P Liberski
Dept Molecular Pathology, Medical University Lodz, Czechoslowacka Street 8 10, PL 92 216 Lodz, Poland
Folia Neuropathol 47:195-204. 2009We review here the history, neuropathology, clinical picture and molecular data on transmissible mink encephalopathy (TME)...
- Spatial variation in mercury concentrations in wild mink and river Otter carcasses from the James bay territory, QuÃ©bec, CanadaC Fortin
Faculty of Veterinary Medicine, , CP 5000, St-Hyacinthe, , J2S 7C6 Canada
Arch Environ Contam Toxicol 40:121-7. 2001..In 1993-94, mean total Hg concentration (microg/g, wet weight) in 39 wild mink and 12 river otter carcasses was greatest in fur/hair samples (30.1 and 20...
- High prevalence of Aleutian mink disease virus in free-ranging mink on a remote Danish islandTrine H Jensen
Division of Poultry, Fish, and Fur Animals, National Veterinary Institute, Technical University of Denmark, Hangøvej 2, DK 8200 Aarhus, Denmark
J Wildl Dis 48:497-502. 2012Aleutian mink disease virus (AMDV) causes severe disease in farmed mink (Neovison vison) worldwide. In Denmark, AMDV in farmed mink has been confined to the northern part of the mainland since 2002...
- Effect of late gestation low protein supply to mink (Mustela vison) dams on reproductive performance and metabolism of dam and offspringConnie Frank Matthiesen
Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences, University of Copenhagen, Denmark
Arch Anim Nutr 64:56-76. 2010..been investigated intensively in various animals in recent years, but to the best of our knowledge, not yet in the mink, a strict carnivore. In the present study, minks were fed either a low-protein (LP) diet, i.e...
- Adaptations to fasting in the American mink (Mustela vison): nitrogen metabolismAnne Mari Mustonen
Department of Biology, University of Joensuu, P O Box 111, 80101 Joensuu, Finland
J Comp Physiol B 175:357-63. 2005..The mink has relatively poor adaptations to food deprivation, as it is not able to prolong phase II of fasting with fat as ..
- Mercury and other heavy metals in free-ranging mink of the lower Great Lakes basin, Canada, 1998-2006Pamela A Martin
Environment Canada, Burlington, ON, Canada
Ecotoxicology 20:1701-12. 2011Mercury concentrations were examined in livers of free-ranging mink (Neovison vison) trapped in the lower Great Lakes basin from 1998 to 2006...
- Monitoring blood glucose levels in female mink during the reproductive cycle: 1. Prevention of hyperglycemia during the nursing periodAmber M J Hynes
Nova Scotia Agricultural College, Department of Plant and Animal Sciences and Canadian Centre for Fur Animal Research, PO Box 550, Truro, Nova Scotia B2N 5E3
Can J Vet Res 71:241-8. 2007Nursing sickness, the largest cause of death in female adult mink, is a metabolic disorder characterized by hyperglycemia...
- Mink farms predict Aleutian disease exposure in wild American minkLarissa A Nituch
Environmental and Life Sciences, Trent University, Peterborough, Ontario, Canada
PLoS ONE 6:e21693. 2011..American mink (Neovison vison) populations across Canada appear to be declining, but factors thus far explored have not fully ..
- Prevalence of the Aleutian mink disease virus infection in Nova Scotia, CanadaA H Farid
Department of Plant and Animal Sciences, Nova Scotia Agricultural College, Truro, Nova Scotia, B2N 5E3, Canada
Prev Vet Med 106:332-8. 2012Despite many years of testing mink for serum antibodies against the Aleutian mink disease virus (AMDV) by counterimmunoelectrophoresis (CIEP) and elimination of reactors, this virus has remained the number one disease threat for the mink ..
- Value of mink vomit model in study of anti-emetic drugsFang Zhang
Department of Pharmacology, Medical College of Qingdao University, 38 Dengzhou Road, Qingdao 266021, Shandong Province, China
World J Gastroenterol 12:1300-2. 2006..To establish a new, reliable vomit model of minks...
- Second passage of sheep scrapie and transmissible mink encephalopathy (TME) agents in raccoons (Procyon lotor)A N Hamir
National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, Ames, IA 50010, USA
Vet Pathol 42:844-51. 2005To determine the transmissibility and pathogenicity of sheep scrapie and transmissible mink encephalopathy (TME) agents derived from raccoons (first passage), raccoon kits were inoculated intracerebrally with either TME (one source) or ..
- MHC class II variation in the endangered European mink Mustela lutreola (L. 1761)--consequences for species conservationL Becker
Department of Ethology, University of Osnabruck, Osnabruck, Germany
Immunogenetics 61:281-8. 2009..seriously decreased population density during the last century, the current population of the endangered European mink (Mustela lutreola, L. 1761) has suffered from geographic isolation...
- Mercury concentrations in wild mink (Mustela vison) and river otters (Lontra canadensis) collected from eastern and Atlantic Canada: relationship to age and parasitismKatherine Klenavic
Environmental and Resource Studies, Trent University, 1600 West Bank Drive, Peterborough, ON K9J 7B8, Canada
Environ Pollut 156:359-66. 2008Total mercury (Hg) concentrations were measured in the fur, brain and liver of wild mink (Mustela vison) and river otters (Lontra canadensis) collected from eastern and Atlantic Canada...
- Testing for bias in a sentinel species: contaminants in free-ranging domestic, wild, and hybrid minkJeff Bowman
Wildlife Research and Development Section, Ontario Ministry of Natural Resources, Trent University DNA Building, 2140 East Bank Drive, Peterborough, ON, Canada K9J 7B8
Environ Res 112:77-82. 2012Sentinel species are important tools for studies of biodiversity and environmental health. The American mink (Neovison vison) has long been considered a sentinel of environmental contamination, since the species is known to be sensitive ..
- Landscape barriers reduce gene flow in an invasive carnivore: geographical and local genetic structure of American mink in ScotlandAndrzej Zalewski
Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK
Mol Ecol 18:1601-15. 2009..We investigated the genetic structure of invasive American mink (Neovison vison) in Scotland, and incorporated landscape genetic approaches to examine resultant patterns in ..
- [Nucleotide sequence and genome structure of mink enteritis virus]X Zhao
Institute of Veterinary Medicine, Changchun Veterinary College
Yi Chuan Xue Bao 20:279-84. 1993This paper reports the sequence of the cloned mink enteritis virus (MEV) RF DNA and its 3' end and 5' end structure predicted. MEV genome is near 5064 nucleotides (nt) in length...
- Melatonin reduces mortality from Aleutian disease in mink (Mustela vison)L C Ellis
Department of Biology, Utah State University, Logan 84322 5305, USA
J Pineal Res 21:214-7. 1996..Melatonin protected both a wild type or demi strain and a demi/dark crossed strain of mink from AD...
- Unusual, high genetic diversity of Aleutian mink disease virusA Olofsson
Department of Virology, The National Veterinary Institute, Biomedical Center, S 751 23 Uppsala, Sweden
J Clin Microbiol 37:4145-9. 1999The genetic diversity of Aleutian mink disease virus (AMDV) was examined. Sequences obtained from 35 clinical samples were compared with five published sequences. An unusual, high genetic variability was revealed...
- Role of hepatic de novo lipogenesis in the development of fasting-induced fatty liver in the American mink (Neovison vison)Kirsti Rouvinen-Watt
Department of Plant and Animal Sciences, Nova Scotia Agricultural College, PO Box 550, Truro, NS, Canada B2N 5E3
Br J Nutr 108:1360-70. 2012American mink (Neovison vison) develop fatty liver quickly in response to food deprivation, which results in preferential mobilisation of n-3 PUFA...
- Comparison of hepatic and nephric total mercury concentrations between feral and ranch American mink (Neovison vison) from northwestern PolandElżbieta Kalisińska
Department of Biology and Medical Parasitology, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70 111, Szczecin, Poland
Bull Environ Contam Toxicol 88:802-6. 2012For many years the American mink (Neovison vison) has been used in North America (where it originates from) as a sensitive indirect bioindicator in assessing the degree of mercury (Hg) contamination in terrestrial ecosystems...
- Reactivity of monoclonal antibodies to human CD antigens with cells from minkB Aasted
Department of Veterinary Pathobiology, Immunological Laboratory, Faculty of Life Sciences, University of Copenhagen, Stigbojlen 7, DK 1870 Frederiksberg C, Copenhagen, Denmark
Vet Immunol Immunopathol 119:27-37. 2007..raised against human leukocyte surface antigens were analyzed by flow cytometry for cross reactivities against mink leukocytes. We found 53 mAbs (14%) to cross react...
- Construction of an American mink bacterial artificial chromosome (BAC) library and sequencing candidate genes important for the fur industryRazvan Anistoroaei
University of Copenhagen, Department of Basic Animal and Veterinary Sciences, Division of Animal Genetics and Bioinformatics, Groennegaardsvej 3, Frederiksberg C, Denmark
BMC Genomics 12:354. 2011..Complemented by the newly and fast growing deep sequencing technologies, they provide an excellent source of information in genomics projects...
- Mink cell focus-forming murine leukemia virus killing of mink cells involves apoptosis and superinfectionF K Yoshimura
Department of Immunology and Microbiology, Wayne State University, 540 E Canfield Ave, Detroit, MI 48201, USA
J Virol 75:6007-15. 2001..We have observed that infection of thymic lymphocytes by the mink cell focus-forming murine leukemia virus (MCF MLV) during the preleukemic period resulted in an enhancement of ..
- Risk induced by a native top predator reduces alien mink movementsPälvi Salo
Section of Ecology, Department of Biology, University of Turku, Turku, Finland
J Anim Ecol 77:1092-8. 2008..native top predator, Haliaeetus albicilla (white-tailed sea eagle), on the movements of Mustela vison (American mink), an alien predator in Europe...
- Acute interstitial pneumonia in mink kits inoculated with defined isolates of Aleutian mink disease parvovirusS Alexandersen
Laboratory of Molecular Pathobiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark
Vet Pathol 31:216-28. 1994The present study addressed the causal role of Aleutian mink disease parvovirus (ADV) in acute interstitial pneumonia in mink kits...
- Phylogenetic analysis of the haemagglutinin gene of canine distemper virus strains detected from breeding foxes, raccoon dogs and minks in ChinaJian Jun Zhao
Division of Zoonoses, Institute of Special Economic Animal and Plant Sciences, Chinese Academy of Agricultural Sciences CAAS, 15 Luming Street, Jilin 132109, China
Vet Microbiol 140:34-42. 2010..Whether the diversity between wild-type CDVs and the vaccine strains may affect, to some extent, the efficacy of the vaccines deserves further investigations...
- Coinfecting prion strains compete for a limiting cellular resourceRonald A Shikiya
Department of Medical Microbiology and Immunology, Creighton University, 2500 California Plaza, Omaha, NE 68178, USA
J Virol 84:5706-14. 2010..our model of strain interference, inoculation of the sciatic nerve with the drowsy (DY) strain of the transmissible mink encephalopathy (TME) agent prior to superinfection with the hyper (HY) strain of TME can completely block HY TME ..
- Antibodies to Aleutian mink disease parvovirus in free-ranging European mink (Mustela lutreola) and other small carnivores from southwestern FranceChristine Fournier-Chambrillon
Groupe de Recherche et d Etude pour la Gestion de l Environnement, route de Préchac, 33730 Villandraut, France
J Wildl Dis 40:394-402. 2004Owing to the rapid decline of the European mink (Mustela lutreola) in France, a national conservation action plan has been initiated, in which scientific research to improve understanding of the causes of the decline is one of the primary ..
- Albinism in the American mink (Neovison vison) is associated with a tyrosinase nonsense mutationR Anistoroaei
Division of Animal Genetics and Bioinformatics, Department of Basic Animal and Veterinary Sciences, The Faculty of Life Sciences, University of Copenhagen, Groennegaardsvej 3, DK 1870 Frederiksberg C, Denmark
Anim Genet 39:645-8. 2008Albino phenotypes are documented in various species including the American mink. In other species the albino phenotypes are associated with tyrosinase (TYR) gene mutations; therefore TYR was considered the candidate gene for albinism in ..
- Transmission of transmissible mink encephalopathy to raccoons (Procyon lotor) by intracerebral inoculationAmir N Hamir
National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
J Vet Diagn Invest 16:57-63. 2004To determine the transmissibility of transmissible mink encephalopathy (TME) agent to raccoons and to provide information about clinical course, lesions, and suitability of currently used diagnostic procedures for detection of ..
- European mink-polecat hybridization events: hazards from natural process?T Lodé
The Laboratoire d écologie animale, UMR Paysages and Biodiversité, Universite d Angers, Faculte des Sciences, Belle Beille, 49045 Angers Cedex, France
J Hered 96:89-96. 2005..Here, we report a genetic investigation of sympatric polecat and endangered European mink populations...
- The first linkage map of the American mink (Mustela vison)R Anistoroaei
The Faculty of Life Sciences, Department of Basic Animal and Veterinary Sciences, Division of Animal Genetics and Bioinformatics, Frederiksberg C, Denmark
Anim Genet 38:384-8. 2007Described herein, the first microsatellite linkage map for the American mink consists of 85 microsatellite markers resolved into 17 linkage groups...
- The effects of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on mink (Mustela vison) reproduction and kit survivability and growthK J Beckett
Department of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA
Arch Environ Contam Toxicol 54:123-9. 2008..to 3,3'4,4',5-pentachlorobiphenyl (PCB 126) would have an adverse effect on the reproductive performance of female mink (Mustela vison) and survivability and growth of their kits...
- Mapping of 53 loci in American mink (Mustela vison)S B Kuznetsov
Laboratory of Developmental Genetics, Institute of Cytology and Genetics, Novosibirsk 90, Russia
J Hered 94:386-91. 2003Fifty-three genes were mapped in the American mink genome using polymerase chain reaction (PCR)-based analysis of a Chinese hamster-American mink somatic cell hybrid panel...
- Characterization of a new hybrid mink-mouse clone panel: chromosomal and regional assignments of the GLO, ACY, NP, CKBB, ADH2, and ME1 loci in mink (Mustela vison)S D Pack
Institute of Cytology and Genetics, Academy of Sciences of the USSR, Novosibirsk
Mamm Genome 3:112-8. 1992To expand the mink map, we established a new panel consisting of 23 mink-mouse clones. On the basis of statistical criteria (Wijnen et al. 1977; Burgerhout 1978), we developed a computer program for choice of clones of the panel...
- Transforming growth factor beta1 induces nuclear export of inhibitory Smad7S Itoh
Ludwig Institute for Cancer Research, Biomedical Center Box 595, S 751 24 Uppsala, Sweden
J Biol Chem 273:29195-201. 1998..This suggests that an intact Mad homology 2 domain is important for nuclear localization of Smad7. The nuclear localization of Smad7 suggests a functional role distinct from its antagonistic effect in receptor-mediated Smad activation...
- Analysis of the vp2 gene sequence of a new mutated mink enteritis parvovirus strain in PR ChinaJing Zuo
College of Animal Science and Veterinary Medicine, Jilin University, 5333 Xi an Road, Changchun 130062, China
Virol J 7:124. 2010b>Mink enteritis virus (MEV) causes a highly contagious viral disease of mink with a worldwide distribution. MEV has a linear, single-stranded, negative-sense DNA with a genome length of approximately 5,000 bp...
- Passive transfer of antiviral antibodies restricts replication of Aleutian mink disease parvovirus in vivoS Alexandersen
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840
J Virol 63:9-17. 1989When mink kits were infected neonatally with a highly virulent strain of Aleutian disease virus (ADV), 100% of both Aleutian and non-Aleutian genotype mink died of interstitial pneumonia characterized by permissive ADV infection of ..
- Vaccination with Aleutian mink disease parvovirus (AMDV) capsid proteins enhances disease, while vaccination with the major non-structural AMDV protein causes partial protection from diseaseB Aasted
Department of Veterinary Microbiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark
Vaccine 16:1158-65. 1998..level, the quantity of peripheral blood CD8 lymphocytes, antibody titers to VP1/2 and NS1 proteins and mink death rates...
- Stereotypic behaviour in farm mink (Neovison vison) can be reduced by selectionB K Hansen
Department of Genetics and Biotechnology, University of Aarhus, Tjele, Denmark
J Anim Breed Genet 127:64-73. 2010..All types of SB were included in the analyses. Altogether 1484 adult mink females of the brown colour type were assessed for behaviour traits: SB, active or inactive behaviour, staying in ..
- A species barrier limits transmission of chronic wasting disease to mink (Mustela vison)Robert D Harrington
Department of Comparative Medicine, University of Washington, Seattle, WA 98195 7190, USA
J Gen Virol 89:1086-96. 2008Transmissible mink encephalopathy (TME) occurs as sporadic outbreaks associated with ingestion of feed presumably contaminated with some type of prion disease...
- Dietary accumulation, disposition, and metabolism of technical pentabrominated diphenyl ether (de-71) in pregnant mink (Mustela vison) and their offspringSi Zhang
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
Environ Toxicol Chem 27:1184-93. 2008..As part of a larger study examining the effects of PBDEs on mink (Mustela vison) reproduction and development, we examined congener-specific tissue distribution, maternal transfer, ..
- Aleutian mink disease parvovirus in wild riparian carnivores in SpainS Mañas
Alexandre Gali, Terrassa, Barcelona, Spain
J Wildl Dis 37:138-44. 2001Serious declines in populations of native European mink (Mustela lutreola) have occurred in Europe. One responsible factor may be infectious diseases introduced by exotic American mink (Mustela vison)...
- Molecular characterization of a novel astrovirus associated with disease in minkChristian Mittelholzer
Department of Virology, Swedish Institute for Infectious Disease Control, S 171 82 Solna, Sweden
J Gen Virol 84:3087-94. 2003Pre-weaning diarrhoea is a well-known problem in mink farming in Europe, causing morbidity that varies between farms, regions and season...
- Molecular characterization of the Himalayan minkBernhard F Benkel
Department of Plant and Animal Sciences, Nova Scotia Agricultural College, P O Box 550, Truro, NS, B2N 5E3, Canada
Mamm Genome 20:256-9. 2009A rare color variant of the American mink (Neovison vison), discovered on a ranch in Nova Scotia and referred to as the "marbled" variety, carries a distinctive pigment distribution pattern resembling that found in some other species, e.g...
- Zoo-FISH analysis: the American mink (Mustela vison) closely resembles the cat karyotypeH Hameister
Abteilung Medizinische Genetik, Universitat Ulm
Chromosome Res 5:5-11. 1997..DNA probes were used to visualize segments of conserved synteny on metaphase chromosomes of the American mink (Mustela vison). A comparison with the hitherto known gene mapping data shows a high degree of correspondence...
- Mink lung cells and mixed mink lung and A549 cells for rapid detection of influenza virus and other respiratory virusesY T Huang
Department of Pathology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Clin Microbiol 38:422-3. 2000b>Mink lung cells were more sensitive than the commonly used MDCK or pRhMK cells for rapid detection of influenza virus A from clinical specimens...
- Astrovirus epidemiologically linked to pre-weaning diarrhoea in minkL Englund
Department of Small Animals, National Veterinary Institute, SE 751 89 Uppsala, Sweden
Vet Microbiol 85:1-11. 2002Diarrhoea and excessive secretion from the cervical apocrine glands in young, suckling mink kits is a well-known, but poorly defined, syndrome often referred to as "sticky", "greasy", or "wet" kits...
- Cats differ from mink and ferrets in their response to commercial vaccines: a histologic comparison of early vaccine reactionsE Eggers Carroll
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 53706, USA
Vet Pathol 39:216-27. 2002Early histologic changes in lesions at vaccine sites were compared in cats, mink, and ferrets...
- Other animal prion diseasesChristina J Sigurdson
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, USA
Br Med Bull 66:199-212. 2003..ruminants and non-human primates, as well as chronic wasting disease of deer and elk (CWD) and transmissible mink encephalopathy of farmed mink (TME)...
- Application of N-PCR for diagnosis of distemper in dogs and fur animalsA Rzezutka
Department of Carnivores and Fur Animal Diseases, National Veterinary Research Institute, al Partyzantow 57, 24 100, Pulawy, Poland
Vet Microbiol 88:95-103. 2002..reference strains of distemper virus and used for testing biological samples collected from dogs, foxes, ferret and mink with spontaneous distemper...
- Immunocytological analysis of meiotic recombination in the American mink (Mustela vison)P M Borodin
Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Department, Novosibirsk 630090, Russia
Anim Genet 40:235-8. 2009..we estimated the total length of the genetic map, the recombination rate and crossover distribution in the American mink (Mustela vison)...
- Hepatocyte growth factor releases mink epithelial cells from transforming growth factor beta1-induced growth arrest by restoring Cdk6 expression and cyclin E-associated Cdk2 activityM Tsubari
Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
Mol Cell Biol 19:3654-63. 1999Transforming growth factor beta (TGF-beta) potently suppresses Mv1Lu mink epithelial cell growth, whereas hepatocyte growth factor (HGF) counteracts TGF-beta-mediated growth inhibition and induces Mv1Lu cell proliferation (J...
- An extended anchored linkage map and virtual mapping for the American mink genome based on homology to human and dogR Anistoroaei
University of Copenhagen, Department of Basic Animal and Veterinary Sciences, Frederiksberg C, Denmark
Genomics 94:204-10. 2009In this report we present an extended linkage map of the American mink (Neovison vison) consisting of 157 microsatellite markers and comprising at least one linkage group for each of the autosomes...
- Molecular epidemiology of Aleutian mink disease virus in FinlandAnna Knuuttila
Division of Microbiology and Epidemiology, Faculty of Veterinary Medicine, University of Helsinki, Finland
Vet Microbiol 133:229-38. 2009Aleutian mink disease virus (AMDV) is a parvovirus that causes an immune complex-mediated disease in minks...
- Detection of Aleutian disease antibodies in feral American mink in southern EnglandN Yamaguchi
Wildlife Conservation Research Unit, Department of Zoology, University of Oxford
Vet Rec 149:485-8. 2001Fourteen of 27 American mink (Mustela vison) trapped in the upper Thames region were positive for anti-Aleutian disease antibodies...
- Ability of small animal cells to support the postintegration phase of human immunodeficiency virus type-1 replicationAtsushi Koito
Division of Clinical Retrovirology and Infectious Diseases, Center for AIDS Research, Kumamoto University, Kumamoto, 860 0811, Japan
Virology 305:181-91. 2003We examine the potential for a broad range of small animal cells, including rodent, mink, and avian cells, from multiple tissues to support postintegration steps of HIV-1 replication...
- Conservation genetics and population history of the threatened European mink Mustela lutreola, with an emphasis on the west European populationJ R Michaux
Unité de recherches zoogéographiques, Institut Botanique Bat B 22, Universite de Liege, 4000 Liege Sart Tilman, Belgium
Mol Ecol 14:2373-88. 2005..The endangered European mink lives now in at least three well-separated populations in northeast, southeast and west Europe...
- Squamous epithelial proliferation in the jaws of mink fed diets containing 3,3',4,4',5-pentachlorobiphenyl (PCB 126) or 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD)J A Render
Department of Veterinary Pathology and Animal Health Diagnostic Laboratory, Michigan State University, East Lansing 48824-1224, USA
Vet Hum Toxicol 43:22-6. 2001Previous research has shown that ingestion of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) by juvenile mink (kits) caused a lesion in the mandible and maxilla that consisted of proliferation of sQuamous epithelium in the periodontal ligament,..
- Mink epithelial cell killing by pathogenic murine leukemia viruses involves endoplasmic reticulum stressSuparna Nanua
Department of Immunology and Microbiology, Karmanos Cancer Institute, Wayne State University, 540 E Canfield Ave, Detroit, MI 48201, USA
J Virol 78:12071-4. 2004We previously demonstrated that mink cells undergo apoptosis after MCF13 murine leukemia virus (MLV) infection...
- Detection and molecular characterization of cultivable caliciviruses from clinically normal mink and enteric caliciviruses associated with diarrhea in minkM Guo
Food Animal Health Research Program, Department of Veterinary Preventive Medicine, Ohio Agricultural Research and Development Center, Ohio State University, Wooster, Ohio, USA
Arch Virol 146:479-93. 2001..In this report, mink enteric caliciviruses (MEC) were detected in feces from diarrheic mink by both immune electron microscopy (IEM) and ..
- Efficacy of a commercial mycotoxin binder in alleviating effects of ochratoxin A, fumonisin B1, moniliformin and zearalenone in adult minkS J Bursian
Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA
Vet Hum Toxicol 46:122-9. 2004..Because cereal grains are important components of ranch mink diets, mycotoxicoses in mink is a potential problem faced by mink ranchers...
- Detection and sequence analysis of Danish and Swedish strains of mink astrovirusChristian Mittelholzer
Department of Virology, Swedish Institute for Infectious Disease Control, Solna, Sweden
J Clin Microbiol 41:5192-4. 2003The sequences of mink astroviruses collected from 11 farms in Denmark and Sweden were analyzed and found to be homologous with one another but different from those of other astroviruses...
- Co-localization of vascular endothelial growth factor and its two receptors flt-1 and kdr in the mink placentaH Winther
Institute of Anatomy, Physiology and Cell Biology, The Royal Veterinary and Agricultural University, Bulowsvej 13, Copenhagen, DK 1870, Denmark
Placenta 22:457-65. 2001..present study VEGF and its Flt-1(VEGFR-1) and KDR (VEGFR-2) receptors were immunolocalized in the endotheliochorial mink placenta throughout gestation...
- Characterization of recombinant nonecotropic murine leukemia viruses from the wild mouse species Mus spretusYong Tae Jung
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892 0460, USA
J Virol 77:12773-81. 2003..Thymus and spleen cells from MoMLV-inoculated mice were plated on Mus dunni cells and mink cells, since these cells do not support the replication of MoMLV, and cells from A-MLV-inoculated mice were plated ..
- Squamous epithelial lesion of the mandibles and maxillae of wild mink (Mustela vison) naturally exposed to polychlorinated biphenylsKerrie J Beckett
Department of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 24:674-7. 2005..b>Mink (Mustela vison) are a naturally occurring predator in this area and also a species of concern because of their ..
- Fatty acids, lipids, and cytochrome p-450 monooxygenase in hepatic microsomes of minks fed fish-based diets and exposed to Aroclor 1242R Käkelä
Department of Biology, University of Joensuu, Finland
J Toxicol Environ Health A 64:427-46. 2001..In conclusion, in the mink the microsomal fatty acid changes were not directly connected with the ethoxyresorufin O-deethylase (EROD) activity ..
- Perfluorooctanesulfonate and related fluorinated hydrocarbons in mink and river otters from the United StatesKurunthachalam Kannan
National Food Safety and Toxicology Center, Department of Zoology, Institute of Environmental Toxicology, Michigan State University, East Lansing 48824, USA
Environ Sci Technol 36:2566-71. 2002b>Mink and otters are good integrators of their aquatic environments and useful sentinel species for determining exposure to environmental contaminants...
- Serum amyloid P component in mink, a non-glycosylated protein with affinity for phosphorylethanolamine and phosphorylcholineLone A Omtvedt
Department of Rheumatology Institute of Immunology, Rikshospitalet, University of Oslo, Blindern, Norway
Amyloid 11:101-8. 2004Experimental AA amyloidosis in the mink is used as a model for the amyloid disease process. In that context it is important to characterize the different proteins involved in the amyloid formation...
- Zoo-FISH with region-specific paints for mink chromosome 5q: delineation of inter- and intrachromosomal rearrangements in human, pig, and foxN B Rubtsov
Institute of Cytology and Genetics, SB RAS, Novosibirsk, Russia
Cytogenet Cell Genet 90:268-70. 2000..chromosome 17, performed with microdissected painting probes, revealed rearrangements inside these chromosomes in mink and pig and a disruption of this conserved region in the fox...
- Toxicity reference values for mink exposed to 2,3,7,8-tetrachlodibenzo-p-dioxin (TCDD) equivalents (TEQs)A L Blankenship
ENTRIX, Inc, Okemos, 4295 Okemos Road, Suite 101, Okemos, MI 48864, USA
Ecotoxicol Environ Saf 69:325-49. 2008Dietary and tissue residue-based toxicity reference values (TRVs) were derived for mink from the published results of studies in which mink were exposed to polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), biphenyls (PCBs),..
- Aleutian mink disease parvovirus infection of K562 cells is antibody-dependent and is mediated via an Fc(gamma)RII receptorL J Dworak
Laboratory of Persistent Viral Diseases, National Institutes of Health, Hamilton, Montana 59840, U S A
Arch Virol 142:363-73. 1997Aleutian mink disease parvovirus (ADV) infects macrophages but infection is restricted. Using the human macrophage cell line U937, we reported infection to be antibody-dependent [22,23]...
- Dietary exposure of mink (Mustela vison) to fish from the housatonic river, Berkshire County, Massachusetts, USA: effects on reproduction, kit growth, and survivalSteven J Bursian
Department of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 25:1533-40. 2006We evaluated the effects of feeding farm-raised mink (Mustela vison) diets containing polychlorinated biphenyl (PCB)-contaminated fish from the Housatonic River (HR; Berkshire County, MA, USA) on adult reproductive performance and kit ..
- Characterization of a Canadian mink H3N2 influenza A virus isolate genetically related to triple reassortant swine influenza virusCarl A Gagnon
Service de diagnostic, Universite de Montreal, St Hyacinthe, Quebec, Canada
J Clin Microbiol 47:796-9. 2009In 2007, an H3N2 influenza A virus was isolated from Canadian mink. This virus was found to be phylogenetically related to a triple reassortant influenza virus which emerged in Canadian swine in 2005, but it is antigenically distinct...
- Dietary exposure of mink (Mustela vison) to fish from the Housatonic River, berkshire County, Massachusetts, USA: effects on organ weights and histology and hepatic concentrations of polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-P-dioxin toxic Steven J Bursian
Department of Animal Science, Michigan State University, East Lansing, Michigan 48824, USA
Environ Toxicol Chem 25:1541-50. 2006The effects of feeding ranch mink (Mustela vison) diets containing polychlorinated biphenyl (PCB)-contaminated fish (88 gold fish [Carassius auratus] weighing a total of 70.3 kg and 16 carp [Cyprinus carpio] weighing a total of 77...
- Chromosomal mapping of canine-derived BAC clones to the red fox and American mink genomesAnna V Kukekova
James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Hered 100:S42-53. 2009..The further possibility of using canine BAC clones to map genes in the American mink (Mustela vison) genome was also explored...
- Rapid induction of experimental AA amyloidosis in mink by intravenous injection of amyloid enhancing factorRandi Sørby
Norwegian School of Veterinary Science, Oslo, Norway
Amyloid 15:20-8. 2008Studies of amyloid enhancing factor (AEF)-induced amyloidosis are commonly performed in mice. In mink, earlier studies of amyloid A (AA) amyloidosis showed that the predeposition phase was highly variable...
- Towards the Physiologic Function of MiRP-3Daniel I Levy; Fiscal Year: 2010..This application describes the study of the beta subunit MiRP-3, a novel member of the MinK-related peptide superfamily, which can modulate the properties of such K+ channels...
- MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDSCRAIG CLARKSON; Fiscal Year: 2001..l, Kvl.4, Kvl.5, Kv2.l, minK, Kv4.3, HIRK, HERG, and the beta subunits of Kvl.2 and Kv2. 7) The hypothesis that Kv4.2 and/or Kv4...
- Neural Interactions Among Multiple Motor StructuresMarc H Schieber; Fiscal Year: 2010..Project 4, Basal Ganglia - Cortical Interactions in Motor Control (Mink, PI) asks how interactions of the globus pallidus, pars interna, with the primary motor cortex and the ..
- INTERCELLULAR COMMUNICATION AND IMPULSE PROPAGATIONJOSE S JALIFE; Fiscal Year: 2010..1 (KCNJ2) and the delayed rectifier HERG (KCHN2) and KyLQT1 (KCNQ1)/mink (KCNE1) modify the ability of cardiac electrical waves to propagate through non-homogeneous cardiac muscle during ..
- K+ Channel Trafficking and Modulation by Mink and MiRP1Geoffrey W Abbott; Fiscal Year: 2013....
- TRANSCRIPTIONAL CONTROL OF MAMMALIAN BRAIN DEVELOPMENTEseng Lai; Fiscal Year: 2001..hypothesis that BF-1 regulates cell cycle and thus controls number of neurons in telencephalon and as assayed in Mink cell culture system...
- Channels with KCNE Subunits: Conformational DynamicsSteve A N Goldstein; Fiscal Year: 2013..Also called MinK-related peptides (MiRPs), these single-pass transmembrane accessory subunits merit investigation because they are ..
- MOLECULAR ENGINEERING OF RETROVIRAL VACCINESEdward Stephens; Fiscal Year: 1990..different recombinant vaccinia viruses expressing either intact or secreted forms of the gp70/p15E of F-MuLV and mink cell focus forming virus (F- MCFV)...
- Structural Analysis of Voltage-gated Potassium ChannelsROBERT BLAUSTEIN; Fiscal Year: 2006..Shaker channel, and heteromultimeric channels formed from the co-assembly of Shaker-like subunits with minK-related peptides (MiRPs)...
- 5th International Scientific Symposium on Tourette SyndromeKevin Black; Fiscal Year: 2009..The Symposium Co-chairs are Peter Hollenbeck PhD, Jonathan Mink MD PhD, and John Walkup MD, who (as is appropriate for this disorder) collectively represent basic science, child ..
- TARGETING HERG: A MOUSE MODEL OF THE LONG QT SYNDROMEBarry London; Fiscal Year: 2002..HERG subunits interact in-vitro with IsK (minK), a K+ channel beta-subunit that coassembles with KvLQT1 to form the cardiac current IKs...
- Mutations of the type 1 TGF beta receptor in cancerBoris Pasche; Fiscal Year: 2002..Stable transfection of mink lung epitheliall cell lines devoid of TbR-I with either TbR-I or TbR-I(6A) shows that TbR-l(6A) transduces less ..
- MOLECULAR DETERMINANTS OF POTASSIUM CHANNEL DRUG BLOCKDirk Snyders; Fiscal Year: 2003..molecular architecture of the channel protein complex includes function-altering accessory subunits (beta subunits, minK) which may impact on drug binding...
- BLOCK OF MYOCARDIAL ION CHANNELS BY ANTIMALARIAL DRUGSMichael Sanguinetti; Fiscal Year: 2002..myocytes; and 3) determine the mechanism of block by antimalarial drugs of cloned human K+ channels (HERG, KvLQT1/minK, HIRK1) expressed in Xenopus oocytes...
- FKBP12 IN TGF-BETA TYPE I RECEPTOR MEDIATED SIGNALINGTongwen Wang; Fiscal Year: 1999..the interaction has now been confirmed in yeast, in vitro and most recently in mammalian cell lines such as COS and mink Mv1Lu cells...
- CELLULAR IMMUNITY TO ENDOGENOUS AKR LEUKEMIA VIRUSESWilliam Green; Fiscal Year: 1993..leukemia viruses (MuLV); to determine whether it is possible to generate CTL that are specific for recombinant mink cell focus-inducing (MCF) MuLV and if so, to characterize these MCF MuLV directed CTL and define their molecular ..
- VARIATION, IMMUNE ESCAPE, AND PATHOGENESIS OF MULVWilliam Green; Fiscal Year: 2000..Although the proximal leukemogenic MuLV are recombinant mink cell cytopathic focus-inducing (MCF) retroviruses generated at several months of age, the early-arising ecotropic ..
- CALMODULIN KINASE II AND EARLY AFTER DEPOLARIZATIONSMark Anderson; Fiscal Year: 2001..Cardiac cells from a recently engineered MinK gene knock out mouse, will also be available for these studies. This study will take place under the guidance of Dr...
- Molecular Physiology of Human Renal CIC-K ChannelsCARLOS VANOYE; Fiscal Year: 2004..the remarkable discovery that co-expression of CIC-Kb with the previously recognized K plus channel subunit KCNE1 (minK) leads to functional Cl- channels in a heterologous mammalian cell system...
- Role of KVS and MPS Subunits in Basic Neuronal FunctionFederico Sesti; Fiscal Year: 2007..elegans nervous system. In addition we cloned mps-1, the first C. elegans MiRP. MinK Related Peptides (MiRPs) are small transmembrane proteins that associate with K+ channels to alter their function...
- MinK-related peptides(MiRPs): structure and functionSteve Goldstein; Fiscal Year: 2004DESCRIPTION: MinK is a small ion channel subunit with a single transmembrane span. It is active only after assembly with a pore-forming subunit. Nonetheless, MinK is required for normal channel function in some tissues...
- MEMBRANE CURRENTS IN CARDIAC MUSCLEArthur Brown; Fiscal Year: 2003..and may be useful as a chaperone to rescue misprocessed mutants; and 4) study the interactions between KvLQT1 and minK during processing using misprocessed mutants linked to hereditary long QT syndrome (hLQTS) as probes...
- CARDIAC POTASSIUM CHANNEL SUBUNITS AND SUDDEN DEATHMartin Tristani Firouzi; Fiscal Year: 2002..KvLQT1 proteins coassemble with a regulatory subunit, minK, to form the slowly activating cardiac delayed rectifier (Iks) channel...
- Mouse Models to Study MiRP3 PhysiologyDaniel Levy; Fiscal Year: 2009..This application describes the study of the beta subunit MiRP3, a novel member of the MinK-related peptide superfamily, which can modulate the properties of such K+ channels...
- Identification and characterization of molecules important in the immune systemNami McCarty; Fiscal Year: 2007..unreadable] With these combined genomic and RNAi-based methodologies I identified and characterized MINK [unreadable] (Misshapen-NIK-related kinase), which is important for negative selection in the thymus...
- Gene Targets of NKX 2.5 in the Conduction SystemMelvin Scheinman; Fiscal Year: 2004..Finally, we plan to study the role of specific ion channels (i.e. MinK and HCN-1) in the pathogenesis of arrhythmias in the ventricular restricted knockout mouse model...
- DNA FORMS OF MURINE LEUKEMIA VIRUSESFAYTH YOSHIMURA; Fiscal Year: 2007..In our studies of the early stages of thymic lymphoma development in mice, we demonstrated that infection by a mink cell focus-forming (MCF) MLV led to an enhancement of apoptosis of thymic lymphocytes...
- STRAIN PROPERTIES OF THE PRION PROTEINJason Bartz; Fiscal Year: 2002..For each of the aims, the hyper (HY) and drowsy (DY) strains of transmissible mink encephalopathy (TME) will be examined in order to determine the role of strain-specific PrP-res in the ..
- Mechanisms of prion transportRICHARD BESSEN; Fiscal Year: 2008..These studies can determine the role of the olfactory nerve in centrifugal prion spread to the nasal mucosa where agent shedding is a potential route of prion transmission. ..
- Anti-Trypanosomal Agents from a Neotropical CloudforestWILLIAM SETZER; Fiscal Year: 2004..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
- Adrenergic Regulation of HERG ProteinThomas McDonald; Fiscal Year: 2007..Specifically, we aim to: 1. Determine the significance of 14-3-3e and PKA regulation of HERG 2. Examine PKA targeting to HERG channels by AKAPs. 3. Examine PKA-mediated control of trafficking of HERG protein. ..
- Molecular Basis of Automaticity in the MyometriumGlenna Bett; Fiscal Year: 2008..Identification of an ion channel which is the uterine pacemaker offers the opportunity for designing interventions to prevent and delay preterm labor. [unreadable] [unreadable] [unreadable] [unreadable]..
- Novel Therapeutic Agents for Diabetic UlcersJUNG HUANG; Fiscal Year: 2008..The novel antagonists developed in this project should be ideal drug candidates for treating diabetic foot ulcers in humans. [unreadable] [unreadable] [unreadable]..
- Identification of compounds that protect HERG from block by proarrhythmic agentsSabina Kupershmidt; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- mTOR Signaling In Chronic Myelogenous LeukemiaHung Fan; Fiscal Year: 2009..abstract_text> ..
- EXPRESSION AND PATHOGENESIS OF MURINE LEUKEMIA VIRUSHung Fan; Fiscal Year: 2005..low expression. Together, these experiments will provide new and important insights into leukemogenesis by MuLVs. ..
- CARDIAC K+ CHANNEL GENE INTERACTIONS AND ARRHYTHMIASThomas McDonald; Fiscal Year: 2001..We have shown that HERG physically associates with another protein, minK, and that this association regulates IKr activity (7)...
- Molecular Mechanisms of Social BehaviorAnna V Kukekova; Fiscal Year: 2010....
- HAPTOTACTIC REPAIR OF THE MENISCUSCAHIR MCDEVITT; Fiscal Year: 2002..These studies will determine whether exogenous haptotactic factors promote cell recruitment and matrix synthesis to and within meniscal wounds in vitro. ..
- MECHANISMS OF REPOLARIZATION-INDUCED ARRHYTHMIASGuy Salama; Fiscal Year: 2002..abstract_text> ..
- Molecular genetics of tame behaviorANNA KUKEKOVA; Fiscal Year: 2005..A set of candidate genes implicated in human and/or rodent behavior will be evaluated for co segregation with tame and wild type behavioural phenotypes using existing and three-generation experimental fox pedigrees. ..
- ROLES OF POLYPEPTIDE GROWTH FACTORS IN CELL GROWTHJUNG HUANG; Fiscal Year: 2004....
- Gender-Differences in Cardiac Repolarization/ArrhythmiasGuy Salama; Fiscal Year: 2005..abstract_text> ..
- Multidisciplinary Study of Right Ventricular DysplasiaJeffrey Towbin; Fiscal Year: 2005..This integrated research grant proposal offers a substantial prospect of expanding the fund of clinical knowledge regarding ARVD and of localizing the gene(s) responsible for this disorder. ..
- A Novel Immunotoxin for Treatment and Cure of StrabismusLEO CHALUPA; Fiscal Year: 2005..The use of IX-146 could be extended in the future to a wider variety of ophthalmologic, neurologic, and neuromuscular disorders, including blepharospasm as well as other types of dystonias. ..
- MOLECULAR BIOLOGY OF JAAGSIEKTE SHEEP RETROVIRUSHung Fan; Fiscal Year: 2003..These experiments will provide insight into JSRV-induced lung cancer in sheep, and possibly into human BAC. ..
- Factors that Initiate Arrhythamias in Long QT SyndromeGuy Salama; Fiscal Year: 2006..Stimulation paradigms that i) enhance DOR or ii) elicit a bradycardia followed by a tachycardia are more likely to increase the incidence of EADs or TdP. ..
- Defective trafficking Mechanisms in a Cardiac K+ ChannelSabina Kupershmidt; Fiscal Year: 2006..We will develop novel therapeutic strategies designed to correct intracellular processing steps of HERG and possibly other plasma membrane proteins that suffer from defects caused by the same mechanism. ..
- Regulation of Kv3.1 by MiRPs in Auditory NeuronsGEOFFREY ABBOTT; Fiscal Year: 2006..Further, MiRP2 and related subunits MinK and MiRP1 modify Kv3...
- Analysis of minK & MiRP Regulation of Cardiac K ChannelsThomas McDonald; Fiscal Year: 2007There is increasing awareness of the importance of ion channel accessory proteins in regulating heart rhythm. MinK and the related MiRPs are K+ channel regulators encoded by the KCNE family of genes...
- Novel Antagonists for Ameliorating Pulmonary FibrosisJUNG HUANG; Fiscal Year: 2007..The novel antagonists developed in this project should be ideal drug candidates for treating pulmonary fibrosis in humans. [unreadable] [unreadable] [unreadable]..
- High-Speed, Depth-Resolved Images of Cardiac physiologyGuy Salama; Fiscal Year: 2007..We focus here on the heart because therein lie salient problems that are ready to be addressed by this new technology. However, the wide range of possible applications may lead to the commercialization of this new technology. ..