Genomes and Genes
Summary: Semidomesticated variety of European polecat much used for hunting RODENTS and/or RABBITS and as a laboratory animal. It is in the subfamily Mustelinae, family MUSTELIDAE.
Publications344 found, 100 shown here
- Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferretsMasaki Imai
Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
Nature 486:420-8. 2012..The transmissible H5 reassortant virus preferentially recognized human-type receptors, replicated efficiently in ferrets, caused lung lesions and weight loss, but was not highly pathogenic and did not cause mortality...
- Airborne transmission of influenza A/H5N1 virus between ferretsSander Herfst
Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
Science 336:1534-41. 2012..conditions, we genetically modified A/H5N1 virus by site-directed mutagenesis and subsequent serial passage in ferrets. The genetically modified A/H5N1 virus acquired mutations during passage in ferrets, ultimately becoming airborne ..
- In vitro and in vivo characterization of new swine-origin H1N1 influenza virusesYasushi Itoh
Department of Pathology, Shiga University of Medical Science, Ohtsu, Shiga 520 2192, Japan
Nature 460:1021-5. 2009..In mice and ferrets, CA04 and other S-OIV isolates tested replicate more efficiently than a currently circulating human H1N1 virus...
- OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signalingSimone A Fietz
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Nat Neurosci 13:690-9. 2010..Our findings suggest that maintenance of this epithelial property allows integrin-mediated, repeated asymmetric divisions of OSVZ progenitors, providing a basis for neocortical expansion...
- The ferret as a model organism to study influenza A virus infectionJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Dis Model Mech 4:575-9. 2011..We highlight the recent and emerging uses of this species in influenza virus research that are advancing our understanding of virus-host interactions...
- Rapid task-related plasticity of spectrotemporal receptive fields in primary auditory cortexJonathan Fritz
Center for Auditory and Acoustic Research, Institute for Systems Research, Electrical and Computer Engineering, University of Maryland, College Park, Maryland 20742, USA
Nat Neurosci 6:1216-23. 2003..We recorded neuronal responses in the primary auditory cortex of behaving ferrets that were trained to detect a target tone of any frequency...
- New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferretsRobert H E Friesen
Crucell Holland BV, Leiden, The Netherlands
PLoS ONE 5:e9106. 2010..Here we report the latest efficacy data for a representative antibody of this novel class...
- Oseltamivir-resistant pandemic A/H1N1 virus is as virulent as its wild-type counterpart in mice and ferretsMarie Eve Hamelin
CHUQ CHUL Research Center in Infectious Diseases and Laval University, Quebec City, Quebec, Canada
PLoS Pathog 6:e1001015. 2010..replication kinetics in MDCK alpha2,6 cells and in vivo by performing experimental infections of BALB/c mice and ferrets. Despite slightly reduced propagation of the mutant isolate in vitro during the first 24 h, the wild-type (WT) ..
- Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferretsMelissa B Pearce
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 109:3944-9. 2012..High titers of infectious virus were detected in nasal turbinates and nasal wash samples of A(H3N2)v-inoculated ferrets. All four A(H3N2)v viruses possessed the capacity to spread efficiently between cohoused ferrets, and the 2010 ..
- Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and miceTaronna R Maines
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Science 325:484-7. 2009..this study, selected 2009 A(H1N1) influenza isolates were assessed for their ability to cause disease in mice and ferrets and compared with a contemporary seasonal H1N1 virus for their ability to transmit to naïve ferrets through ..
- A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infectionKatharine N Bossart
CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
PLoS Pathog 5:e1000642. 2009..4, targeting the henipavirus G glycoprotein was evaluated in vivo as a potential therapeutic agent. All ferrets that received m102...
- Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammalsDebby van Riel
Department of Virology, Erasmus MC, P O Box 2040, 3015 CA, Rotterdam, The Netherlands
Am J Pathol 171:1215-23. 2007..avian influenza viruses (H5N9 and H6N1) with that of H5N1 virus in respiratory tract tissues of humans, mice, ferrets, cynomolgus macaques, cats, and pigs by virus histochemistry...
- Adaptation of pandemic H1N1 influenza viruses in miceNatalia A Ilyushina
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
J Virol 84:8607-16. 2010..These modulators of virulence, therefore, may have been the driving components of early evolution, which paved the way for novel 2009 viruses in mammals...
- Eurasian-origin gene segments contribute to the transmissibility, aerosol release, and morphology of the 2009 pandemic H1N1 influenza virusSeema S Lakdawala
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS Pathog 7:e1002443. 2011..All viruses replicated well in the upper respiratory tract of infected ferrets, suggesting that factors other than viral replication are important for the release of influenza virus particles ..
- Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferretsVincent J Munster
National Influenza Center and Department of Virology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
Science 325:481-3. 2009..Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles...
- Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferretsJonathan A McCullers
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
J Infect Dis 202:1287-95. 2010..In a novel model of transmission in ferrets, we demonstrated that pneumococcal transmission and disease were enhanced if donors had previously been infected ..
- Aerosol transmission of influenza A virus: a review of new studiesRaymond Tellier
Provincial Laboratory for Public Health of Alberta, Calgary, Canada
J R Soc Interface 6:S783-90. 2009..These recent results and their implication for infection control of influenza are discussed in this review...
- A role for intermediate radial glia in the tangential expansion of the mammalian cerebral cortexIsabel Reillo
Developmental Neurobiology Unit, Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
Cereb Cortex 21:1674-94. 2011..Thus, the generation of IRGCs plays a key role in the tangential expansion of the mammalian cerebral cortex...
- Pathogenesis and transmission of triple-reassortant swine H1N1 influenza viruses isolated before the 2009 H1N1 pandemicJessica A Belser
Influenza Division, Infectious Disease Pathology Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 85:1563-72. 2011..Utilizing TRS and 2009 H1N1 viruses, we conducted extensive hematologic and blood serum analyses on infected ferrets to identify lymphohematopoietic parameters associated with mild to severe influenza virus infection...
- Physiological and anatomical evidence for multisensory interactions in auditory cortexJennifer K Bizley
Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, UK
Cereb Cortex 17:2172-89. 2007..mutual information that visual stimuli can influence the activity of units in the auditory cortex of anesthetized ferrets. In many cases, these units were also acoustically responsive and frequently transmitted more information in ..
- Modeling host responses in ferrets during A/California/07/2009 influenza infectionThomas Rowe
International Institute of Infection and Immunity at Shantou Medical College, 22 Xingling Rd, Shantou, Guangdong 515041, People s Republic of China
Virology 401:257-65. 2010..Using an experimental infection model in ferrets, we examined the pathological features and characterized the host immune responses by using microarray analysis, ..
- Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenzaYoko Shoji
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
Vaccine 27:1087-92. 2009..Immunization of mice and ferrets with plant-derived hemagglutinin elicited serum hemagglutinin-inhibiting antibodies and protected the ferrets ..
- A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferretsAkila Jayaraman
Harvard MIT Division of Health Sciences and Technology, Singapore MIT Alliance for Research and Technology, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
PLoS ONE 6:e17616. 2011..a 2009 H1N1 virus carrying this mutation in the RBS (generated using reverse genetics) transmits efficiently in ferrets by respiratory droplets thereby reestablishing our previously observed correlation between human receptor-binding ..
- Influenza virus aerosol exposure and analytical system for ferretsKortney M Gustin
Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 108:8432-7. 2011..We report the development of an inoculation method that delivers an influenza virus aerosol inoculum to ferrets and the characterization of size distribution and viable virus present in aerosols shed from infected ferrets ..
- Severity of pneumonia due to new H1N1 influenza virus in ferrets is intermediate between that due to seasonal H1N1 virus and highly pathogenic avian influenza H5N1 virusJudith M A van den Brand
Department of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands
J Infect Dis 201:993-9. 2010..Three influenza pandemics of the previous century caused variable mortality, which largely depended on the development of severe pneumonia. However, the ability of the new H1N1 virus to cause pneumonia is poorly understood...
- Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmissionSander Herfst
Department of Virology, Erasmus Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, Netherlands
J Virol 84:3752-8. 2010..The mutations had no major impact on virus replication in the respiratory tracts of mice and ferrets or on pathogenesis. All three mutant viruses were transmitted via aerosols or respiratory droplets in ferrets...
- Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the airNeal Van Hoeven
Influenza Division, Mailstop G 16, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 106:3366-71. 2009..necessary for efficient direct contact transmission, but did not allow respiratory droplet transmission between ferrets of an avian influenza virus possessing an avian polymerase subunit PB2...
- In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificityLi Mei Chen
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
Virology 422:105-13. 2012..The complex changes required for airborne transmissibility in ferrets suggest that extensive evolution is needed for H5N1 transmissibility in humans.
- A recombinant Hendra virus G glycoprotein-based subunit vaccine protects ferrets from lethal Hendra virus challengeJackie Pallister
CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, VIC 3220, Australia
Vaccine 29:5623-30. 2011..We report that ferrets vaccinated with a 100 μg, 20 μg or 4 μg dose of HeVsG remained free of clinical signs of HeV infection ..
- Course of seasonal influenza A/Brisbane/59/07 H1N1 infection in the ferretAlexis McBrayer
Southern Research Institute, Birmingham, AL 35205, USA
Virol J 7:149. 2010..The results provided here offer important endpoints for preclinical testing of the efficacy of new antiviral compounds and experimental vaccines...
- Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferretsSusu Duan
Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
PLoS Pathog 6:e1001022. 2010..We found that the oseltamivir-resistant H1N1/2009 virus was not transmitted efficiently in ferrets via respiratory droplets (0/2), while it retained efficient transmission via direct contact (2/2)...
- Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 virusesTaronna R Maines
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G16, Atlanta, GA 30333, USA
Virology 413:139-47. 2011..the H5 HA, the rescued mutant viruses displayed reduced replication in vitro and delayed peak virus shedding in ferrets. An improvement in transmission efficiency was not observed with any of the mutants compared to the parental ..
- Rapid synaptic depression explains nonlinear modulation of spectro-temporal tuning in primary auditory cortex by natural stimuliStephen V David
Institute for Systems Research, University of Maryland, College Park, Maryland 20742, USA
J Neurosci 29:3374-86. 2009..This dynamic reshaping of spectro-temporal tuning suggests that synaptic depression may enable efficient encoding of natural auditory stimuli...
- Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferretsCheryl M Cameron
Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong, P R China
J Virol 82:11308-17. 2008..expressed innate immune response genes in lungs from H5N1 (A/Vietnam/1203/04) influenza virus-infected ferrets by oligonucleotide microarray analysis...
- Minimal molecular constraints for respiratory droplet transmission of an avian-human H9N2 influenza A virusErin M Sorrell
Department of Veterinary Medicine, University of Maryland, College Park, and Virginia Maryland Regional College of Veterinary Medicine, 8075 Greenmead Drive, College Park, MD 20742, USA
Proc Natl Acad Sci U S A 106:7565-70. 2009..This report illustrates that aerosolized respiratory transmission is not exclusive to current human H1, H2, and H3 influenza subtypes...
- The multibasic cleavage site in H5N1 virus is critical for systemic spread along the olfactory and hematogenous routes in ferretsEefje J A Schrauwen
National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
J Virol 86:3975-84. 2012..Here we determined the virus distribution of HPAI H5N1 virus in ferrets in time and space-including along the olfactory route-and the role of the MBCS in systemic replication...
- A ferret model of canine distemper virus virulence and immunosuppressionVeronika von Messling
Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55905, USA
J Virol 77:12579-91. 2003Canine distemper virus (CDV) infects many carnivores, including ferrets and dogs, and is the member of the Morbillivirus genus most easily amenable to experimentation in a homologous small-animal system...
- NS1-mediated delay of type I interferon induction contributes to influenza A virulence in ferretsIsabelle Meunier
INRS Institut Armand Frappier, University of Quebec, Laval, QC H7V 1B7, Canada
J Gen Virol 92:1635-44. 2011..Infection of ferrets with the recombinant viruses revealed that the presence of the 1918 NS1 resulted in a slightly more severe ..
- Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferretsIsabelle Meunier
INRS Institut Armand Frappier, Laval, Quebec, Canada
Virology 422:125-31. 2012..Mexican isolate A/Mexico/InDRE4487/2009 and a mild Canadian isolate A/Canada-AB/RV1532/2009 was compared in ferrets. These viruses differed at nine residues, none of which has been previously identified as virulence factor...
- Glycosylation at 158N of the hemagglutinin protein and receptor binding specificity synergistically affect the antigenicity and immunogenicity of a live attenuated H5N1 A/Vietnam/1203/2004 vaccine virus in ferretsWeijia Wang
MedImmune, 319 North Bernardo Ave, Mountain View, CA 94043, USA
J Virol 84:6570-7. 2010..alpha2,3-linked sialosides (alpha2,3SAL), and a single dose induces a minimal serum antibody response in mice and ferrets. In contrast, A/Hong Kong/213/2003 (H5N1) vaccine virus (HK03 ca) binds to both alpha2,6SAL and alpha2,3SAL and ..
- Properly folded bacterially expressed H1N1 hemagglutinin globular head and ectodomain vaccines protect ferrets against H1N1 pandemic influenza virusSurender Khurana
Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
PLoS ONE 5:e11548. 2010..The traditional process of influenza vaccine production in eggs is time consuming and may not meet the demands of rapid global vaccination required to curtail influenza pandemic...
- Immunogenicity and protective efficacy of a live attenuated vaccine against the 2009 pandemic A H1N1 in mice and ferretsPenghui Yang
Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China
Vaccine 29:698-705. 2011..challenge by the wild-type (wt) 2009 pandemic A H1N1 (A/Beijing/501/2009 or A/California/07/2009) in mice and ferrets. These results support the evaluation of this vaccine made from a wt strain isolated in China for clinical trials.
- Effect of the neuraminidase mutation H274Y conferring resistance to oseltamivir on the replicative capacity and virulence of old and recent human influenza A(H1N1) virusesMariana Baz
Research Center in Infectious Diseases of the Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada
J Infect Dis 201:740-5. 2010..Unexpectedly, an oseltamivir-resistant A(H1N1) variant containing the H274Y neuraminidase (NA) mutation recently disseminated worldwide, suggesting that the replication and virulence properties of this mutant virus were not compromised...
- Measurement of neutralizing antibody responses against H5N1 clades in immunized mice and ferrets using pseudotypes expressing influenza hemagglutinin and neuraminidaseCheguo Tsai
The Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
Vaccine 27:6777-90. 2009..Thus, we conclude that the PN assay is a sensitive and quantifiable method to measure neutralizing antibodies against diverse clades and subclades of H5N1 influenza virus...
- The ferret auditory cortex: descending projections to the inferior colliculusVictoria M Bajo
Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford OX1 3PT, UK
Cereb Cortex 17:475-91. 2007..This pattern of corticocollicular connectivity is consistent with regional differences in physiological properties and provides another basis for subdividing ferret auditory cortex into functionally distinct areas...
- Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A virusesGraeme E Price
Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
Vaccine 27:6512-21. 2009..to nucleoprotein (NP) and matrix 2 (M2) by DNA priming followed by parenteral or mucosal boosting in mice and ferrets. DNA vaccination followed by boosting with antigen-matched recombinant adenovirus (rAd) or cold-adapted (ca) ..
- H5N1 Virus Attachment to Lower Respiratory TractDebby van Riel
Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
Science 312:399. 2006..These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion...
- Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferretsHui Ling Yen
Department of Microbiology, HKU Pasteur Research Centre, University of Hong Kong, Pokfulam, Hong Kong SAR, China
Proc Natl Acad Sci U S A 108:14264-9. 2011..the pandemic H1N1 virus among humans, we evaluated the direct-contact and respiratory-droplet transmissibility in ferrets of representative swine influenza viruses of different lineages obtained through a 13-y surveillance program in ..
- Vaccination against seasonal influenza A/H3N2 virus reduces the induction of heterosubtypic immunity against influenza A/H5N1 virus infection in ferretsR Bodewes
Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, P O Box 2040, 3000 CA Rotterdam, Netherlands
J Virol 85:2695-702. 2011..Here we demonstrate that infection with a recent influenza A/H3N2 virus strain induces robust protection in ferrets against infection with a highly pathogenic avian influenza virus of the H5N1 subtype...
- A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmissionTerrence M Tumpey
Influenza Branch, Mailstop G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Science 315:655-9. 2007..to the avian alpha-2,3 sialic acid resulted in a virus incapable of respiratory droplet transmission between ferrets but that maintained its lethality and replication efficiency in the upper respiratory tract...
- The descending corticocollicular pathway mediates learning-induced auditory plasticityVictoria M Bajo
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Nat Neurosci 13:253-60. 2010..We examined the role of these neurons in experience-dependent recalibration of sound localization in adult ferrets by selectively killing the neurons using chromophore-targeted laser photolysis...
- PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal modelsRong Hai
Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029 6574, USA
J Virol 84:4442-50. 2010..Our results show enhanced replication of the 66S virus in A549 cells, while studies of BALB/c and DBA/2 mice and ferrets revealed no significant differences in symptoms of infection with wild-type Cal/09 versus the 66N or 66S virus ..
- Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 inductionNicholas Svitek
INRS Institut Armand Frappier, University of Quebec, Laval, QC, Canada
Virology 376:53-9. 2008Even though ferrets are one of the principal animal models for influenza pathogenesis, the lack of suitable immunological reagents has so far limited their use in host response studies...
- Comparative analysis of the subventricular zone in rat, ferret and macaque: evidence for an outer subventricular zone in rodentsVeronica Martinez-Cerdeno
Department of Pathology and Laboratory Medicine, School of Medicine, University of California Davis, Sacramento, California, United States of America
PLoS ONE 7:e30178. 2012..We immunostained sections of the developing cerebral cortex from lissencephalic rats, and from gyrencephalic ferrets and macaques to compare the distribution of precursor cell types in each species...
- Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchusIva Kelava
Max Planck Institute of Molecular Cell Biology and Genetics, D 01307 Dresden, Germany
Cereb Cortex 22:469-81. 2012....
- The multibasic cleavage site of the hemagglutinin of highly pathogenic A/Vietnam/1203/2004 (H5N1) avian influenza virus acts as a virulence factor in a host-specific manner in mammalsAmorsolo L Suguitan
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Virol 86:2706-14. 2012..H5N1) or lacked (ΔH5N1) the H5 HA MBS were generated and evaluated for their virulence in BALB/c mice, ferrets, and African green monkeys (AGMs) (Chlorocebus aethiops)...
- Sample size considerations for one-to-one animal transmission studies of the influenza A virusesHiroshi Nishiura
School of Public Health, The University of Hong Kong, Hong Kong SAR, China
PLoS ONE 8:e55358. 2013..The analyses are illustrated on transmission studies of influenza A viruses in the ferret model...
- Cedar virus: a novel Henipavirus isolated from Australian batsGlenn A Marsh
CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia
PLoS Pathog 8:e1002836. 2012..Preliminary challenge studies with CedPV in ferrets and guinea pigs, both susceptible to infection and disease with known henipaviruses, confirmed virus replication ..
- A sensitive retroviral pseudotype assay for influenza H5N1-neutralizing antibodiesNigel J Temperton
MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London, United Kingdom
Influenza Other Respir Viruses 1:105-12. 2007..We have used retroviral pseudotypes bearing influenza H5 hemagglutinin (HA) as safe, surrogate viruses for influenza neutralization assays which can be carried out at Biosafety Level 2...
- Interdependent encoding of pitch, timbre, and spatial location in auditory cortexJennifer K Bizley
Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
J Neurosci 29:2064-75. 2009..Such nonlinearities were most prevalent in primary auditory cortex, although they tended to be small compared with stimulus main effects...
- Local innate immune responses and influenza virus transmission and virulence in ferretsTaronna R Maines
Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 205:474-85. 2012Host innate immunity is the first line of defense against invading pathogens, including influenza viruses. Ferrets are well recognized as the best model of influenza virus pathogenesis and transmission, but little is known about the ..
- The 2009 pandemic H1N1 D222G hemagglutinin mutation alters receptor specificity and increases virulence in mice but not in ferretsYacine Abed
Research Center in Infectious Diseases, CHUQ CHUL and Laval University, Quebec City, Canada
J Infect Dis 204:1008-16. 2011..We investigated the impact of this mutation in vitro and in animal models using recombinant pH1N1 viruses...
- Avian influenza h6 viruses productively infect and cause illness in mice and ferretsLaura Gillim-Ross
Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
J Virol 82:10854-63. 2008..and their abilities to replicate and induce a cross-reactive immune response in two animal models: mice and ferrets. The different H6 viruses replicated to different levels in the respiratory tracts of mice and ferrets, causing ..
- Assessment of the efficacy of the neuraminidase inhibitor oseltamivir against 2009 pandemic H1N1 influenza virus in ferretsElena A Govorkova
Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
Antiviral Res 91:81-8. 2011..Oseltamivir (25 mg/kg/day twice daily for 5 days) was orally administered to groups of ferrets, starting either 2 or 24 h after inoculation with 10(6)PFU of A/California/04/2009 (H1N1) influenza virus...
- Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeysJiang Fan
Department of Vaccine and Biologics Research, Merck Research Laboratories, 770 Sumneytown Pike, P O Box 4, WP16 306, West Point, PA 19486, USA
Vaccine 22:2993-3003. 2004..to keyhole limpet hemocyanin (KLH) or Neisseria meningitidis outer membrane protein complex (OMPC)) in mice, ferrets, and rhesus monkeys...
- Retinal origin of orientation maps in visual cortexSe Bum Paik
Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
Nat Neurosci 14:919-25. 2011..we show that such a pattern is observed in individuals of four different species: monkeys, cats, tree shrews and ferrets. The proposed mechanism explains how orientation maps can develop without requiring precise patterns of ..
- Comparative pathology in ferrets infected with H1N1 influenza A viruses isolated from different hostsJennifer Humberd Smith
Department of Infectious Diseases, Animal Health Research Center, University of Georgia, 111 Carlton Street, Athens, GA 30602, USA
J Virol 85:7572-81. 2011Virus replication and pulmonary disease pathogenesis in ferrets following intranasal infection with a pandemic influenza virus strain (A/California/4/09 [CA09]), a human seasonal influenza H1N1 virus isolate (A/New Caledonia/20/99 [..
- Insertion of a multibasic cleavage site in the haemagglutinin of human influenza H3N2 virus does not increase pathogenicity in ferretsEefje J A Schrauwen
National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
J Gen Virol 92:1410-5. 2011..However, studies in ferrets demonstrated that insertion of the MBCS into HA did not result in increased virus shedding, cellular host range, ..
- Pandemic H1N1 influenza virus causes a stronger inflammatory response than seasonal H1N1 influenza virus in ferretsYoung Myong Kang
Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Gung Dong, Yuseong Gu, Daejeon, Korea
Arch Virol 156:759-67. 2011..To better understand the pathogenic mechanism, clinical signs and inflammatory responses in ferrets infected with the pandemic H1N1 were compared with those caused by seasonal H1N1 influenza virus...
- Cellular and network mechanisms of rhythmic recurrent activity in neocortexM V Sanchez-Vives
Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
Nat Neurosci 3:1027-34. 2000..The spontaneous generation and failure of this self-excited state may account for the generation of a subset of cortical rhythms during sleep...
- Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibitionBilal Haider
Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 26:4535-45. 2006..in the prefrontal cortex in vivo, during the slow (<1 Hz) oscillation in ketamine-xylazine-anesthetized ferrets. We measured persistent network activity (Up states) with extracellular multiple unit and local field potential ..
- Transcriptome sequencing and development of an expression microarray platform for the domestic ferretCarl E Bruder
Southern Research Institute, Birmingham, AL 35205, USA
BMC Genomics 11:251. 2010..We present here a parallel sequencing effort to produce an extensive EST (expressed sequence tags) dataset derived from a normalized ferret cDNA library made from mRNA from ferret blood, liver, lung, spleen and brain...
- Molecular characterization of a novel coronavirus associated with epizootic catarrhal enteritis (ECE) in ferretsAnnabel G Wise
Diagnostic Center for Population and Animal Health, Lansing, MI 48909, USA
Virology 349:164-74. 2006A novel coronavirus, designated as ferret enteric coronavirus (FECV), was identified in feces of domestic ferrets clinically diagnosed with epizootic catarrhal enteritis (ECE)...
- Efficacy of live attenuated influenza vaccine in children against influenza B viruses by lineage and antigenic similarityRobert B Belshe
Saint Louis University Health Science Center, St Louis, MO 63104, USA
Vaccine 28:2149-56. 2010....
- A plant-produced influenza subunit vaccine protects ferrets against virus challengeVadim Mett
Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
Influenza Other Respir Viruses 2:33-40. 2008....
- Design, assembly, and validation of a nose-only inhalation exposure system for studies of aerosolized viable influenza H5N1 virus in ferretsRichard S Tuttle
Aerosol Research and Engineering Laboratories, 13300 West 98th Street, Lenexa, Kansas 66215, USA
Virol J 7:135. 2010..model that is a surrogate for humans, an inhalation exposure system for studies of aerosolized H5N1 viruses in ferrets was designed, assembled, and validated...
- Impact of prior seasonal influenza vaccination and infection on pandemic A (H1N1) influenza virus replication in ferretsA H Ellebedy
Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
Vaccine 29:3335-9. 2011..inactivated vaccine (TIV) might be playing in this immunity we conducted a vaccination-challenge study in ferrets. Vaccination with TIV was unable to alter subsequent morbidity or contact transmission in ferrets following ..
- Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferretsMatthew J Memoli
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Infect Dis 203:348-57. 2011....
- Genetic immunization in the lung induces potent local and systemic immune responsesKaimei Song
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 107:22213-8. 2010..in a lethal challenge model, we show that aerosolized recombinant adenoviral immunization completely protects ferrets against H5N1 highly pathogenic avian influenza virus...
- Evidence of human-to-swine transmission of the pandemic (H1N1) 2009 influenza virus in South KoreaMin Suk Song
College of Medicine and Medical Research Institute, Chungbuk National University, 12 Gaeshin Dong Heungduk Ku, Cheongju City, 361 763 Republic of Korea
J Clin Microbiol 48:3204-11. 2010..Animal studies (ferrets and mice) reveal that swine pandemic isolates epitomize biological properties attributed to the currently ..
- Molecular characterization of in vivo adjuvant activity in ferrets vaccinated against influenza virusYuan Fang
Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong 515041, People s Republic of China
J Virol 84:8369-88. 2010..adjuvant potential of CpG oligodeoxynucleotide (ODN) when used with a human seasonal influenza virus vaccine in ferrets. We found that the CpG ODN-adjuvanted vaccine effectively increased antibody production and activated type I ..
- The development of vaccine viruses against pandemic A(H1N1) influenzaJames S Robertson
Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar EN6 3QG, UK
Vaccine 29:1836-43. 2011..Two approaches were followed, the classical reassortment approach and the more recent reverse genetics approach. This report describes the development and the characteristics of current pandemic H1N1 candidate vaccine viruses...
- Chloroquine administration does not prevent Nipah virus infection and disease in ferretsJackie Pallister
CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
J Virol 83:11979-82. 2009..Chloroquine was assessed using a ferret model of lethal Nipah virus infection and found to be ineffective against Nipah virus infection in vivo...
- Ferrets develop fatal influenza after inhaling small particle aerosols of highly pathogenic avian influenza virus A/Vietnam/1203/2004 (H5N1)John A Lednicky
Energy and Life Sciences Division, Midwest Research Institute, 425 Volker Boulevard, Kansas City, Missouri 64110, USA
Virol J 7:231. 2010..b>Ferrets are often used as a animal model for humans in influenza pathogenicity and transmissibility studies...
- Adaptation to stimulus statistics in the perception and neural representation of auditory spaceJohannes C Dahmen
Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford OX1 3PT, UK
Neuron 66:937-48. 2010..how auditory spatial processing adapts to stimulus statistics by presenting human listeners and anesthetized ferrets with noise sequences in which interaural level differences (ILD) rapidly fluctuated according to a Gaussian ..
- Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferretsNatalia A Ilyushina
Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
PLoS Pathog 6:e1000933. 2010..None of the recombinant H5N1 viruses had attenuated virulence in ferrets inoculated with 10(6) EID(50) dose...
- Possible increased pathogenicity of pandemic (H1N1) 2009 influenza virus upon reassortmentEefje J A Schrauwen
National Influenza Centre and Erasmus Medical Center Department of Virology, Rotterdam, The Netherlands
Emerg Infect Dis 17:200-8. 2011..pandemic (H1N1) 2009 virus with respect to replication kinetics in vitro and pathogenicity and transmission in ferrets. Pandemic (H1N1) 2009 viruses containing basic polymerase 2 alone or in combination with acidic polymerase of ..
- Barrages of synaptic activity control the gain and sensitivity of cortical neuronsYousheng Shu
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 23:10388-401. 2003..These results indicate that rapid increases in neuronal responsiveness, as well as increases in spike timing precision, can be achieved through balanced barrages of excitatory and inhibitory synaptic activity...
- Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957Claudia Pappas
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
PLoS ONE 5:e11158. 2010..HA and displayed dual binding to both alpha 2,6 and alpha 2,3 glycan receptors, transmitted efficiently to naïve ferrets by respiratory droplets...
- Assessing the viral fitness of oseltamivir-resistant influenza viruses in ferrets, using a competitive-mixtures modelAeron C Hurt
WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria 3051, Australia
J Virol 84:9427-38. 2010..b>Ferrets were coinfected with either pure populations (100% susceptible wild-type or 100% oseltamivir-resistant mutant ..
- Neural ensemble codes for stimulus periodicity in auditory cortexJennifer K Bizley
Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom, and Robotics, Brain, and Cognitive Sciences Department, Italian Institute of Technology, 16163 Genova, Italy
J Neurosci 30:5078-91. 2010We measured the responses of neurons in auditory cortex of male and female ferrets to artificial vowels of varying fundamental frequency (f(0)), or periodicity, and compared these with the performance of animals trained to discriminate ..
- PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathwayA Robichaud
Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe Claire, Dorval, Quebec, Canada H9R 4P8
Neuropharmacology 40:262-9. 2001..assess the role of alpha(2)-adrenoceptors in emesis induced by inhibitors of type 4 phosphodiesterase (PDE4) in ferrets. Pre-treatment with yohimbine, MK-912 or MK-467 (alpha(2)-adrenoceptor antagonists) caused sudden and unexpected ..
- Use of animal models to understand the pandemic potential of highly pathogenic avian influenza virusesJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Adv Virus Res 73:55-97. 2009..As avian influenza viruses continue to cause human disease and death, animal pathogenesis studies identify avenues of investigation for novel preventative and therapeutic agents that could be effective in the event of a future pandemic...
- Task difficulty and performance induce diverse adaptive patterns in gain and shape of primary auditory cortical receptive fieldsSerin Atiani
Neuroscience and Cognitive Sciences Program, University of Maryland, College Park, MD 20742, USA
Neuron 61:467-80. 2009..These adaptive STRF changes were largest in high-performance sessions, confirming a close correlation with behavior...
- Intranasal administration of alpha interferon reduces seasonal influenza A virus morbidity in ferretsDaniela Kugel
Department of Virology, University of Freiburg, Freiburg, Germany
J Virol 83:3843-51. 2009..the protective potential of exogenous IFN-alpha against seasonal and highly pathogenic influenza viruses in ferrets. Intranasal treatment with IFN-alpha several hours before infection with the H1N1 influenza A virus strain A/USSR/..
- Ferrets as a transmission model for influenza: sequence changes in HA1 of type A (H3N2) virusM L Herlocher
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
J Infect Dis 184:542-6. 2001b>Ferrets were used as an animal model to study whether controlled transmission of type A influenza is similar to human transmission when sequence changes in HA1 are used as the outcome...
- The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04Rachelle Salomon
Department of Infectious Diseases, St Jude Children s Research Hospital, and Department of Pathology, University of Tennessee, Memphis, TN 38105, USA
J Exp Med 203:689-97. 2006..a fatal human case isolate, and nonlethal A/chicken/Vietnam/C58/04 (CH58) and tested their pathogenicity in ferrets and mice...
- The receptive-field organization of simple cells in primary visual cortex of ferrets under natural scene stimulationDarragh Smyth
Laboratory of Physiology, Oxford University, Oxford OX1 3PT, United Kingdom
J Neurosci 23:4746-59. 2003..We recorded from simple cells in the primary visual cortex of anesthetized ferrets while stimulating with flashed digitized photographs of natural scenes...
- The contribution of sensory experience to the maturation of orientation selectivity in ferret visual cortexL E White
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Nature 411:1049-52. 2001..Orientation maps were present in dark-reared ferrets, but fully mature levels of tuning were never attained...
- Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airwaysS Kirkeby
Dental School, Faculty of Health Sciences, University of Copenhagen, Denmark
Virus Res 144:225-32. 2009Glycans terminating in sialic acids serve as receptors for influenza viruses. In this study ferrets were infected with influenza virus A/New Caledonia/20/99, and the in situ localization of sialic acids linked alpha2-3 and alpha2-6 in ..
- The contribution of animal models to the understanding of the host range and virulence of influenza A virusesChristopher D O'Donnell
Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
Microbes Infect 13:502-15. 2011Since ferrets were first used in 1933 during the initial isolation of influenza A viruses, animal models have been critical for influenza research...
- Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret ModelZoe Stewart; Fiscal Year: 2013..However, CF ferrets have high perinatal mortality from abnormal intestinal and pancreatic function, altered glucose and lipid ..
- Liver disease in CF: CFTR controls innate immunity in biliary epitheliumMario Strazzabosco; Fiscal Year: 2013..These studies will be performed in Cftr-defective mice and in ferrets, a novel CF model that spontaneously develops CFLD...
- Fatty Acid Defects &Oxidative Stress Modulate Islet Function in Cystic FibrosisAliye Uc; Fiscal Year: 2013..birth, both models have abnormal insulin secretion, but the concomitant exocrine pancreatic disease is mild in CF ferrets and advanced in CF pigs...
- Peptide inhbitors of influenza entry-FAST TRACKRussell B Wilson; Fiscal Year: 2011..This 16mer peptide, Flufirvitide-3, potently inhibited signs of influenza in ferrets, generally considered the best animal model for influenza...
- Pathological Evaluation of a Cystic Fibrosis Ferret ModelJohn F Engelhardt; Fiscal Year: 2010..Preliminary analysis of CFTR-deficient newborn ferrets demonstrates that they are afflicted by meconium ileus, defects in cAMP-mediated chloride transport in the airway ..
- Structural determinants of DTI observations in developing cortex and white matterChristopher D Kroenke; Fiscal Year: 2013..to induce abnormal patterns of neural connections in the visual cortex of altricial species such as rodents and ferrets. We chose ferrets because they have a relatively large cerebral WM to gray matter (GM) ratio, which makes it ..
- Surrogate endpoints for correlating protective immunity in response to influenza Gary Fujii; Fiscal Year: 2010..of our present proposal is to confirm that the L-IAVM2e1-HD vaccine will provide similar protective immunity in ferrets and non-human primates...
- Preclinical Development of m102.4, a Human Anti-Hendra and Nipah AntibodyTimothy R Fouts; Fiscal Year: 2013..4, that potently neutralizes all available NiV and HeV isolates in vitro and provided post-exposure protection of ferrets from NiV challenge and of African Green Monkeys (AGM) from HeV challenge. We believe that m102...
- Eritoran (E5564), a TLR4 antagonist, as a novel therapeutic for influenzaStefanie N Vogel; Fiscal Year: 2013..against non-adapted human strains of virus and in a model of aged/immunocompromised animals, and finally, in ferrets, to confirm and extend the use of Eritoran using pandemic strains of influenza under ABSL3 conditions...
- Pandemic H5N1 vaccine containing recombinant H5 and a synthetic TLR4 agonist, GLAChristopher H Clegg; Fiscal Year: 2010..If successful, then rH5+GLA adjuvant will be tested in virus challenge models by inoculating mice and ferrets with two strains of H5N1...
- rAAV-directed gene therapy to the lung in cystic fibrosis ferret modelsJohn F Engelhardt; Fiscal Year: 2013..The CFTR-knockout ferrets demonstrate two lung colonization phenotypes that will be useful in developing therapies for CF-rapidly lethal ..
- Novel nanotechnology based oral influenza vaccinesSang Moo Kang; Fiscal Year: 2011..In addition, we will evaluate the efficacy of oral vaccination in ferrets, which is a more relevant animal model for testing pre-clinical influenza vaccines for humans...
- Near-infrared laser to replace chemical vaccine adjuvantSatoshi Kashiwagi; Fiscal Year: 2013..response to skin-based influenza vaccination using established animal models of influenza infection in mice and ferrets, 2) Elucidation of the cellula and molecular mechanisms of action of the NIR laser adjuvant in vitro and in vivo, ..
- Development of sG as a human vaccine against Nipah/HendraTimothy R Fouts; Fiscal Year: 2013..Immunization and challenge studies performed in cats, ferrets, and nonhuman primates using recombinant HeV soluble attachment protein G, HeV-sG, have demonstrated that a HeV-..
- Development of a novel adjuvant for vaccine sparingHao Shen; Fiscal Year: 2013..antibody and cellular responses after one immunization with the co-administered TIV flu vaccine in mice and ferrets using minimal immunogen consumption...
- Foundation Immunogens for Influenza VaccinesEric A Weaver; Fiscal Year: 2013..A final analysis will be done in ferrets, since ferrets more closely resemble natural influenza infection in humans...
- Virus-Like Particle Vaccine for SARS-CoVRAPHAEL PAUL VISCIDI; Fiscal Year: 2010..SARS-CoV VLP vaccines in BALB/c mice;and (3) to determine the potency of a VLP vaccine to protect BALB/c mice and ferrets challenged with live SARS-CoV...
- Development of Influenza Virus-Like Particle (VLP) VaccinesInnocent N Mbawuike; Fiscal Year: 2011..dosage and adjuvant formulations for enhancement of vaccine potency and antigen sparing in preclinical studies in ferrets. C) Perform small scale cGMP vaccine production and toxicology studies for a Pre-Innovation Drug Application (IND)..
- IVIS Spectrum CT Imaging System in BSL-3 ContainmentKATHERINE D RYMAN; Fiscal Year: 2013..anticipated use of the CVR/RBL laboratories includes pathogenesis and challenge studies in mice, rats, rabbits, ferrets and small NHPs, each of which are amenable to imaging in the IVIS Spectrum CT system...
- Neural Correlates of Streaming of Complex SoundsShihab A Shamma; Fiscal Year: 2013..The approach involves a combination of simultaneous single-unit recordings and behavioral tasks in ferrets, and psychophysical measures in humans...
- Transmissibility of avian influenza viruses in mammalsYoshihiro Kawaoka; Fiscal Year: 2013..These mutant H5 HAs did not support virus transmission among ferrets (an established influenza virus transmission model) via respiratory droplets, but acquired this ability after two ..
- Transmissibility of avian influenza viruses in mammalsYoshihiro Kawaoka; Fiscal Year: 2012..These mutant H5 viruses did not transmit among ferrets (an established influenza virus transmission model) via respiratory droplets (aerosols), but acquired this ..
- Influenza vaccines inducing broadly cross protective immunitySang Moo Kang; Fiscal Year: 2013..efficacy of promising vaccine candidates and the duration of cross protection will be further evaluated in ferrets, which is a more relevant animal model for testing pre-clinical vaccines for humans...
- Development of a Universal Influenza Seasonal VaccineDavid B Weiner; Fiscal Year: 2013..resulting in broad HI activity at protective levels (greater than 1/40 HI titers in an indicator animal species - Ferrets). Studies in ferrets will include challenge with pandemic as well as seasonal strains...
- Reagents for the analyses of CMI in the ferret influenza model.KAREN MARIE DUUS; Fiscal Year: 2012DESCRIPTION (provided by applicant): Ferrets have the potential to become an important animal model of influenza infection, as they most closely demonstrate the disease symptoms and pathology that occurs in humans...
- Antigenic Relationships of SARS and Animal CoronavirusesLinda Saif; Fiscal Year: 2006..SARS CoV experimentally infects macaques, ferrets and cats...
- Developing a Novel Mumps Virus VaccineBiao He; Fiscal Year: 2013..We propose to develop a novel mumps virus vaccine by attenuating virus through introducing mutations at desirable locations within the genome and to test immunogenicity of vaccine candidates in mice and ferrets.
- Boosting Flu Vaccination without Adjuvant InjectionMei X Wu; Fiscal Year: 2013..Finally, we will extend the investigation to H5N1 pandemic flu vaccine, protecting mice and ferrets from a lethal challenge of a highly pathogenic avian H5N1 flu virus after one dose of the stockpiled H5N1 vaccine ..
- VLP Vaccine TechnologySang Moo Kang; Fiscal Year: 2013..In the aim 3, we will extend the preclinical efficacy tests of VLP vaccines to cotton rats (RSV VLPs) and ferrets (novel universal influenza VLPs)...
- Omics-Based Predictive Modeling of Age-Dependent Outcome to Influenza InfectionElodie Ghedin; Fiscal Year: 2013..We propose to use an age-dependent animal model (neonatal, adult and aged ferrets) and clinical human samples to collect biological measurements at multiple scales of host-virus interaction...
- Circuit mechanisms governing the development of direction selectivityGORDON BRAWN SMITH; Fiscal Year: 2013..Furthermore, in visually naove ferrets brief exposure to a drifting grating stimulus (motion training) is sufficient to drive the emergence of direction ..
- Number Representation in PrimatesElizabeth M Brannon; Fiscal Year: 2010..Animal genera as diverse as rats, pigeons, ferrets, raccoons, monkeys, and apes have been shown to make numerical judgments with stimuli that include light flashes, ..
- The Effects of Antibodies on Vascular Permeability in Dengue Virus InfectionLindsey E Bazzone; Fiscal Year: 2013..b>Ferrets that are either mock treated or treated with HMAbs will subsequently be challenged with DENV and assessed for ..
- CARDIAC & VASCULAR TOXICITY OF COCAINEJames Morgan; Fiscal Year: 1991..Electrical and mechanical studies will be performed with cardiac and vascular tissue from swine and ferrets that has been loaded with the calcium indicator aequorin to directly measure intracellular levels of free, ..
- BSL-3/ABSL-3 Expansion for Select Agent Translational ResearchColleen Jonsson; Fiscal Year: 2010..CPM) Regional Biocontainment Laboratory (RBL) to support work with select agents utilizing rodents, rabbits and ferrets as animal models in long term efficacy/product evaluation studies...
- MECHANISMS GOVERNING ONSET OF OVARIAN FUNCTIONKathleen Ryan; Fiscal Year: 1990..The proximate cause of ovarian activation at puberty in ferrets and several other species is a marked decrease in the efficacy of estradiol to inhibit LH secretion...
- Development of a SARS Coronavirus VaccineJeffrey Ulmer; Fiscal Year: 2004..the inactivated SARS-CoV vaccine under cGMP and complete a preclinical package, including efficacy studies in ferrets and monkeys, which will provide the basis for a subsequent clinical trial under Specific Aim 2...
- Peptide drugs against influenza virusRobert Garry; Fiscal Year: 2007..Specific Aim 2 is to evaluate the efficacy of lead peptides in ferrets, the small animal model that best recapitulates human influenza virus pathogenesis...
- NATURAL AND INDUCED IMMUNITY AGAINST HELICOBACTER PYLORIPierre Michetti; Fiscal Year: 2001..In contrast, oral immunization in mice and ferrets with various H. pylori antigens can prevent and even cure Helicobacter infection, indicating that H...
- NATURAL AND INDUCED IMMUNITY AGAINST HELICOBACTER PYLORIPierre Michetti; Fiscal Year: 2000..In contrast, oral immunization in mice and ferrets with various H. pylori antigens can prevent and even cure Helicobacter infection, indicating that H...
- MECHANISM OF BACTERIAL SUPERINFECTIONBARBARA SANFORD; Fiscal Year: 1991..We have selected to use ferrets (Mustela putorius furo), which are small carnivores, because influenza in the ferret most resembles the disease ..
- CAROTENOID BINDING PROTEIN AND CAROTENOID METABOLISMRaj Lakshman; Fiscal Year: 2002..Our ongoing studies in ferrets showed the following: 1. 0.5 percent taurocholate (TC) and 13...
- Lycopene Chemoprevention of Lung Cancer in FerretXiang Dong Wang; Fiscal Year: 2010..and the prevention (or promotion) of premalignant and malignant lung lesions in smoke-exposed, carcinogen-treated ferrets;2) lycopene (or lycopene metabolites) inhibit lung carcinogenesis by up-regulating insulin-likegrowth factor ..
- Biologic Activity of LycopeneXiang Dong Wang; Fiscal Year: 2002..of lycopene in vitro in the tissue of smoke-exposed versus non smoke-exposed lung and prostate tissues of ferrets. These studies will provide important information for the potential future use of lycopene as cancer preventive ..
- BRUGIAN FILARIASIS IN THE FERRETCATHERINE CRANDALL; Fiscal Year: 1990..3) To identify cytokines regulating eosinophil activity in infected ferrets by assays for chemotaxis/chemokinesis and by activation of adherence and cytotoxicity to microfilariae...
- EFFECT OF OXIDANT POLLUTANTS ON AIRWAY SECRETIONMATTHEW MARIN; Fiscal Year: 1990..Two experimental models will be employed: 1) explants of tracheal submucosal glands of ferrets; and 2) tantalum coated surface of pig trachea, in vivo (hillock experiments)...
- BEHAVIORAL EFFECTS OF SEX STEROIDSMichael Baum; Fiscal Year: 1999..of olfactory bulb deafferentation on sexual partner preference in gonadectomized, steroid-treated male and female ferrets. He will also determine whether intracerebroventricular infusion of galanin or of a galanin antagonist modifies ..
- T5000 Diagnostic System in Ferret Model of InfluenzaFrederick Koster; Fiscal Year: 2009..identify the earliest time and respiratory secretion site of viral detection by TIGER, we will test secretions of ferrets infected by intranasal H3N2 and H5N1 strains in the ABSL-3 laboratory at LRRI...
- DOES PULMONARY SURFACTANT REACT WITH INHALED POLLUTANTS?BARBARA FINLAYSON PITTS; Fiscal Year: 1993..Questions to be addressed through in vivo studies include: (1) Are ferrets an appropriate animal model for oxidant inhalation? (2) Can reaction products characteristic of the PS-oxidant ..
- HORMONAL CONTROL OF DELAYED IMPLANTATIONRODNEY MEAD; Fiscal Year: 1991..I then propose to demonstrate by passive immunization of ferrets and spotted skunks, that antibodies to LIF will inhibit implantation...
- INTERPLAY BETWEEN THE HA AND NA OF INFLUENZA VIRUSESLarisa Gubareva; Fiscal Year: 2003..determine how changes in the HA and/or NA of zanamivir-resistant mutants affect the virulence of such viruses in ferrets. The major strength of this application is (i) availability of well-characterized zanamivir-resistant mutants ..
- FACILITY FOR NON-HUMAN PRIMATES IN INFECTIOUS DIS RESRICHARD BRADBURY; Fiscal Year: 1993..viruses and rotaviruses will be done in squirrel, owl, patas, rhesus, and African Green monkeys, and possibly ferrets. Studies with respiratory tract infections will, particularly, be focused on testing of candidate vaccine strains ..
- Structural correlates of rapid cortical plasticityMriganka Sur; Fiscal Year: 2010..two-photon laser scanning microscopy in vivo and in vitro, and viral expression of exogenous proteins, in ferrets and mice, to examine: (1) the time course of functional changes in the ferret visual cortex during the critical ..
- CWD--MODEL OF NVCJD AND LYMPHOID PATHOGENESIS IN TSE'SEdward Hoover; Fiscal Year: 2003..In aim 2 therefore they will expose ferrets to infectious CWD prions orally and determine by sequential sampling whether PrPres is detectable in lymphoid ..
- JUVENILE LUNG--TOXICOLOGICAL MODEL FOR CHILDRENRONALD RASMUSSEN; Fiscal Year: 1992..The experimental approach will be to expose neonate ferrets daily to moderate levels of NO2 or a model particulate until they reach adult size...
- Biodefense vaccine for pandemic influenzaLawrence Smith; Fiscal Year: 2005..AIM 1: Vaccination of mice and ferrets with pDNAs encoding human NP(concensus) and S7(concensus) and the avian HA(A/Vietnam/1194/04) genes and challenge ..
- Epileptogenic Mechanisms in Developmental MalformationsKIMBERLE JACOBS; Fiscal Year: 2005..Because brain development in ferrets is immature at birth, deletion of selective cellular laminae can be achieved...
- Adenoviral Vector-based Pandemic Influenza VaccineSURESH MITTAL; Fiscal Year: 2009..Naive and primed inbred mice and outbred ferrets will be used for immunization and challenge trials to address the complex spectrum of immunity that would exist ..
- AFFERENTS TO LHRH NEURONS AND MAMMALIAN REPRODUCTIONJoan King; Fiscal Year: 1992..Animal models will include: - 1) spontaneous ovulators with a luteal phase, guinea pigs; 2) induced ovulators, ferrets; 3) seasonal ovulators, bats; and 4) once only ovulators, lamprey...
- MECHANISMS OF VISUAL CONTEXT EFFECTS IN VISUAL CORTEXJonathan Levitt; Fiscal Year: 2003..1) In electrophysiological and neuroanatomical experiments in adult monkeys and ferrets, we will test whether the spatial extent and topography of response suppression or enhancement from beyond the ..
- STRUCTURAL CORRELATES OF CORTICAL INFORMATION PROCESSINGSharon L Juliano; Fiscal Year: 2010..cells? These studies will use organotypic cultures and transplantation of neural progenitor cells into neonatal ferrets. We expect these experiments to lead to novel ideas about factors mediating tangential migration of neurons ..
- MECHANISMS OF VISUAL SYSTEM MATURATIONVivien Casagrande; Fiscal Year: 1990..Each of the specific aims is designed to test aspects of this model in the developing LGN of tree shrews and ferrets. SPECIFIC AIM 1 will determine whether the developmental sequence of growth of afferents and dendrites supports ..
- ACTIVITY DEPENDENT MECHANISMS OF VISUAL DEVELOPMENTMriganka Sur; Fiscal Year: 2002..of specific connections between retinal ganglion cell axons and cells of the lateral geniculate nucleus (LGN) in ferrets, during the sorting of retinogeniculate projections into on-center and off-center sublaminae...
- INTRINSIC NEURAL SIGNALING IN PRIMATE PREFRONTAL CORTEXLEONID KRIMER; Fiscal Year: 2002..Experiments will be conducted initially in ferrets and then in nonhuman primates and in human temporal cortex surgically removed for the treatment of intractable ..