ferrets

Summary

Summary: Semidomesticated variety of European polecat much used for hunting RODENTS and/or RABBITS and as a laboratory animal. It is in the subfamily Mustelinae, family MUSTELIDAE.

Top Publications

  1. pmc Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
    Masaki Imai
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
    Nature 486:420-8. 2012
  2. ncbi Airborne transmission of influenza A/H5N1 virus between ferrets
    Sander Herfst
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Science 336:1534-41. 2012
  3. pmc In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
    Yasushi Itoh
    Department of Pathology, Shiga University of Medical Science, Ohtsu, Shiga 520 2192, Japan
    Nature 460:1021-5. 2009
  4. ncbi OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
    Simone A Fietz
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Nat Neurosci 13:690-9. 2010
  5. pmc The ferret as a model organism to study influenza A virus infection
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Dis Model Mech 4:575-9. 2011
  6. ncbi Rapid task-related plasticity of spectrotemporal receptive fields in primary auditory cortex
    Jonathan Fritz
    Center for Auditory and Acoustic Research, Institute for Systems Research, Electrical and Computer Engineering, University of Maryland, College Park, Maryland 20742, USA
    Nat Neurosci 6:1216-23. 2003
  7. pmc New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets
    Robert H E Friesen
    Crucell Holland BV, Leiden, The Netherlands
    PLoS ONE 5:e9106. 2010
  8. pmc Oseltamivir-resistant pandemic A/H1N1 virus is as virulent as its wild-type counterpart in mice and ferrets
    Marie Eve Hamelin
    CHUQ CHUL Research Center in Infectious Diseases and Laval University, Quebec City, Quebec, Canada
    PLoS Pathog 6:e1001015. 2010
  9. pmc Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets
    Melissa B Pearce
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 109:3944-9. 2012
  10. pmc Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 325:484-7. 2009

Detail Information

Publications344 found, 100 shown here

  1. pmc Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets
    Masaki Imai
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
    Nature 486:420-8. 2012
    ..The transmissible H5 reassortant virus preferentially recognized human-type receptors, replicated efficiently in ferrets, caused lung lesions and weight loss, but was not highly pathogenic and did not cause mortality...
  2. ncbi Airborne transmission of influenza A/H5N1 virus between ferrets
    Sander Herfst
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Science 336:1534-41. 2012
    ..conditions, we genetically modified A/H5N1 virus by site-directed mutagenesis and subsequent serial passage in ferrets. The genetically modified A/H5N1 virus acquired mutations during passage in ferrets, ultimately becoming airborne ..
  3. pmc In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
    Yasushi Itoh
    Department of Pathology, Shiga University of Medical Science, Ohtsu, Shiga 520 2192, Japan
    Nature 460:1021-5. 2009
    ..In mice and ferrets, CA04 and other S-OIV isolates tested replicate more efficiently than a currently circulating human H1N1 virus...
  4. ncbi OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
    Simone A Fietz
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Nat Neurosci 13:690-9. 2010
    ..Our findings suggest that maintenance of this epithelial property allows integrin-mediated, repeated asymmetric divisions of OSVZ progenitors, providing a basis for neocortical expansion...
  5. pmc The ferret as a model organism to study influenza A virus infection
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Dis Model Mech 4:575-9. 2011
    ..We highlight the recent and emerging uses of this species in influenza virus research that are advancing our understanding of virus-host interactions...
  6. ncbi Rapid task-related plasticity of spectrotemporal receptive fields in primary auditory cortex
    Jonathan Fritz
    Center for Auditory and Acoustic Research, Institute for Systems Research, Electrical and Computer Engineering, University of Maryland, College Park, Maryland 20742, USA
    Nat Neurosci 6:1216-23. 2003
    ..We recorded neuronal responses in the primary auditory cortex of behaving ferrets that were trained to detect a target tone of any frequency...
  7. pmc New class of monoclonal antibodies against severe influenza: prophylactic and therapeutic efficacy in ferrets
    Robert H E Friesen
    Crucell Holland BV, Leiden, The Netherlands
    PLoS ONE 5:e9106. 2010
    ..Here we report the latest efficacy data for a representative antibody of this novel class...
  8. pmc Oseltamivir-resistant pandemic A/H1N1 virus is as virulent as its wild-type counterpart in mice and ferrets
    Marie Eve Hamelin
    CHUQ CHUL Research Center in Infectious Diseases and Laval University, Quebec City, Quebec, Canada
    PLoS Pathog 6:e1001015. 2010
    ..replication kinetics in MDCK alpha2,6 cells and in vivo by performing experimental infections of BALB/c mice and ferrets. Despite slightly reduced propagation of the mutant isolate in vitro during the first 24 h, the wild-type (WT) ..
  9. pmc Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets
    Melissa B Pearce
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 109:3944-9. 2012
    ..High titers of infectious virus were detected in nasal turbinates and nasal wash samples of A(H3N2)v-inoculated ferrets. All four A(H3N2)v viruses possessed the capacity to spread efficiently between cohoused ferrets, and the 2010 ..
  10. pmc Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 325:484-7. 2009
    ..this study, selected 2009 A(H1N1) influenza isolates were assessed for their ability to cause disease in mice and ferrets and compared with a contemporary seasonal H1N1 virus for their ability to transmit to naïve ferrets through ..
  11. pmc A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection
    Katharine N Bossart
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
    PLoS Pathog 5:e1000642. 2009
    ..4, targeting the henipavirus G glycoprotein was evaluated in vivo as a potential therapeutic agent. All ferrets that received m102...
  12. pmc Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals
    Debby van Riel
    Department of Virology, Erasmus MC, P O Box 2040, 3015 CA, Rotterdam, The Netherlands
    Am J Pathol 171:1215-23. 2007
    ..avian influenza viruses (H5N9 and H6N1) with that of H5N1 virus in respiratory tract tissues of humans, mice, ferrets, cynomolgus macaques, cats, and pigs by virus histochemistry...
  13. pmc Adaptation of pandemic H1N1 influenza viruses in mice
    Natalia A Ilyushina
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 3678, USA
    J Virol 84:8607-16. 2010
    ..These modulators of virulence, therefore, may have been the driving components of early evolution, which paved the way for novel 2009 viruses in mammals...
  14. pmc Eurasian-origin gene segments contribute to the transmissibility, aerosol release, and morphology of the 2009 pandemic H1N1 influenza virus
    Seema S Lakdawala
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 7:e1002443. 2011
    ..All viruses replicated well in the upper respiratory tract of infected ferrets, suggesting that factors other than viral replication are important for the release of influenza virus particles ..
  15. ncbi Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets
    Vincent J Munster
    National Influenza Center and Department of Virology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
    Science 325:481-3. 2009
    ..Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles...
  16. pmc Influenza enhances susceptibility to natural acquisition of and disease due to Streptococcus pneumoniae in ferrets
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    J Infect Dis 202:1287-95. 2010
    ..In a novel model of transmission in ferrets, we demonstrated that pneumococcal transmission and disease were enhanced if donors had previously been infected ..
  17. pmc Aerosol transmission of influenza A virus: a review of new studies
    Raymond Tellier
    Provincial Laboratory for Public Health of Alberta, Calgary, Canada
    J R Soc Interface 6:S783-90. 2009
    ..These recent results and their implication for infection control of influenza are discussed in this review...
  18. ncbi A role for intermediate radial glia in the tangential expansion of the mammalian cerebral cortex
    Isabel Reillo
    Developmental Neurobiology Unit, Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
    Cereb Cortex 21:1674-94. 2011
    ..Thus, the generation of IRGCs plays a key role in the tangential expansion of the mammalian cerebral cortex...
  19. pmc Pathogenesis and transmission of triple-reassortant swine H1N1 influenza viruses isolated before the 2009 H1N1 pandemic
    Jessica A Belser
    Influenza Division, Infectious Disease Pathology Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 85:1563-72. 2011
    ..Utilizing TRS and 2009 H1N1 viruses, we conducted extensive hematologic and blood serum analyses on infected ferrets to identify lymphohematopoietic parameters associated with mild to severe influenza virus infection...
  20. ncbi Physiological and anatomical evidence for multisensory interactions in auditory cortex
    Jennifer K Bizley
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, UK
    Cereb Cortex 17:2172-89. 2007
    ..mutual information that visual stimuli can influence the activity of units in the auditory cortex of anesthetized ferrets. In many cases, these units were also acoustically responsive and frequently transmitted more information in ..
  21. pmc Modeling host responses in ferrets during A/California/07/2009 influenza infection
    Thomas Rowe
    International Institute of Infection and Immunity at Shantou Medical College, 22 Xingling Rd, Shantou, Guangdong 515041, People s Republic of China
    Virology 401:257-65. 2010
    ..Using an experimental infection model in ferrets, we examined the pathological features and characterized the host immune responses by using microarray analysis, ..
  22. ncbi Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza
    Yoko Shoji
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE 19711, USA
    Vaccine 27:1087-92. 2009
    ..Immunization of mice and ferrets with plant-derived hemagglutinin elicited serum hemagglutinin-inhibiting antibodies and protected the ferrets ..
  23. pmc A single base-pair change in 2009 H1N1 hemagglutinin increases human receptor affinity and leads to efficient airborne viral transmission in ferrets
    Akila Jayaraman
    Harvard MIT Division of Health Sciences and Technology, Singapore MIT Alliance for Research and Technology, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e17616. 2011
    ..a 2009 H1N1 virus carrying this mutation in the RBS (generated using reverse genetics) transmits efficiently in ferrets by respiratory droplets thereby reestablishing our previously observed correlation between human receptor-binding ..
  24. pmc Influenza virus aerosol exposure and analytical system for ferrets
    Kortney M Gustin
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 108:8432-7. 2011
    ..We report the development of an inoculation method that delivers an influenza virus aerosol inoculum to ferrets and the characterization of size distribution and viable virus present in aerosols shed from infected ferrets ..
  25. ncbi Severity of pneumonia due to new H1N1 influenza virus in ferrets is intermediate between that due to seasonal H1N1 virus and highly pathogenic avian influenza H5N1 virus
    Judith M A van den Brand
    Department of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Infect Dis 201:993-9. 2010
    ..Three influenza pandemics of the previous century caused variable mortality, which largely depended on the development of severe pneumonia. However, the ability of the new H1N1 virus to cause pneumonia is poorly understood...
  26. pmc Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission
    Sander Herfst
    Department of Virology, Erasmus Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, Netherlands
    J Virol 84:3752-8. 2010
    ..The mutations had no major impact on virus replication in the respiratory tracts of mice and ferrets or on pathogenesis. All three mutant viruses were transmitted via aerosols or respiratory droplets in ferrets...
  27. pmc Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air
    Neal Van Hoeven
    Influenza Division, Mailstop G 16, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 106:3366-71. 2009
    ..necessary for efficient direct contact transmission, but did not allow respiratory droplet transmission between ferrets of an avian influenza virus possessing an avian polymerase subunit PB2...
  28. ncbi In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity
    Li Mei Chen
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
    Virology 422:105-13. 2012
    ..The complex changes required for airborne transmissibility in ferrets suggest that extensive evolution is needed for H5N1 transmissibility in humans.
  29. pmc A recombinant Hendra virus G glycoprotein-based subunit vaccine protects ferrets from lethal Hendra virus challenge
    Jackie Pallister
    CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, VIC 3220, Australia
    Vaccine 29:5623-30. 2011
    ..We report that ferrets vaccinated with a 100 μg, 20 μg or 4 μg dose of HeVsG remained free of clinical signs of HeV infection ..
  30. pmc Course of seasonal influenza A/Brisbane/59/07 H1N1 infection in the ferret
    Alexis McBrayer
    Southern Research Institute, Birmingham, AL 35205, USA
    Virol J 7:149. 2010
    ..The results provided here offer important endpoints for preclinical testing of the efficacy of new antiviral compounds and experimental vaccines...
  31. pmc Oseltamivir-resistant pandemic H1N1/2009 influenza virus possesses lower transmissibility and fitness in ferrets
    Susu Duan
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    PLoS Pathog 6:e1001022. 2010
    ..We found that the oseltamivir-resistant H1N1/2009 virus was not transmitted efficiently in ferrets via respiratory droplets (0/2), while it retained efficient transmission via direct contact (2/2)...
  32. ncbi Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G16, Atlanta, GA 30333, USA
    Virology 413:139-47. 2011
    ..the H5 HA, the rescued mutant viruses displayed reduced replication in vitro and delayed peak virus shedding in ferrets. An improvement in transmission efficiency was not observed with any of the mutants compared to the parental ..
  33. pmc Rapid synaptic depression explains nonlinear modulation of spectro-temporal tuning in primary auditory cortex by natural stimuli
    Stephen V David
    Institute for Systems Research, University of Maryland, College Park, Maryland 20742, USA
    J Neurosci 29:3374-86. 2009
    ..This dynamic reshaping of spectro-temporal tuning suggests that synaptic depression may enable efficient encoding of natural auditory stimuli...
  34. pmc Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets
    Cheryl M Cameron
    Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong, P R China
    J Virol 82:11308-17. 2008
    ..expressed innate immune response genes in lungs from H5N1 (A/Vietnam/1203/04) influenza virus-infected ferrets by oligonucleotide microarray analysis...
  35. pmc Minimal molecular constraints for respiratory droplet transmission of an avian-human H9N2 influenza A virus
    Erin M Sorrell
    Department of Veterinary Medicine, University of Maryland, College Park, and Virginia Maryland Regional College of Veterinary Medicine, 8075 Greenmead Drive, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 106:7565-70. 2009
    ..This report illustrates that aerosolized respiratory transmission is not exclusive to current human H1, H2, and H3 influenza subtypes...
  36. pmc The multibasic cleavage site in H5N1 virus is critical for systemic spread along the olfactory and hematogenous routes in ferrets
    Eefje J A Schrauwen
    National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Virol 86:3975-84. 2012
    ..Here we determined the virus distribution of HPAI H5N1 virus in ferrets in time and space-including along the olfactory route-and the role of the MBCS in systemic replication...
  37. pmc A ferret model of canine distemper virus virulence and immunosuppression
    Veronika von Messling
    Molecular Medicine Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Virol 77:12579-91. 2003
    Canine distemper virus (CDV) infects many carnivores, including ferrets and dogs, and is the member of the Morbillivirus genus most easily amenable to experimentation in a homologous small-animal system...
  38. ncbi NS1-mediated delay of type I interferon induction contributes to influenza A virulence in ferrets
    Isabelle Meunier
    INRS Institut Armand Frappier, University of Quebec, Laval, QC H7V 1B7, Canada
    J Gen Virol 92:1635-44. 2011
    ..Infection of ferrets with the recombinant viruses revealed that the presence of the 1918 NS1 resulted in a slightly more severe ..
  39. ncbi Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets
    Isabelle Meunier
    INRS Institut Armand Frappier, Laval, Quebec, Canada
    Virology 422:125-31. 2012
    ..Mexican isolate A/Mexico/InDRE4487/2009 and a mild Canadian isolate A/Canada-AB/RV1532/2009 was compared in ferrets. These viruses differed at nine residues, none of which has been previously identified as virulence factor...
  40. pmc Glycosylation at 158N of the hemagglutinin protein and receptor binding specificity synergistically affect the antigenicity and immunogenicity of a live attenuated H5N1 A/Vietnam/1203/2004 vaccine virus in ferrets
    Weijia Wang
    MedImmune, 319 North Bernardo Ave, Mountain View, CA 94043, USA
    J Virol 84:6570-7. 2010
    ..alpha2,3-linked sialosides (alpha2,3SAL), and a single dose induces a minimal serum antibody response in mice and ferrets. In contrast, A/Hong Kong/213/2003 (H5N1) vaccine virus (HK03 ca) binds to both alpha2,6SAL and alpha2,3SAL and ..
  41. pmc Properly folded bacterially expressed H1N1 hemagglutinin globular head and ectodomain vaccines protect ferrets against H1N1 pandemic influenza virus
    Surender Khurana
    Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America
    PLoS ONE 5:e11548. 2010
    ..The traditional process of influenza vaccine production in eggs is time consuming and may not meet the demands of rapid global vaccination required to curtail influenza pandemic...
  42. ncbi Immunogenicity and protective efficacy of a live attenuated vaccine against the 2009 pandemic A H1N1 in mice and ferrets
    Penghui Yang
    Beijing Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China
    Vaccine 29:698-705. 2011
    ..challenge by the wild-type (wt) 2009 pandemic A H1N1 (A/Beijing/501/2009 or A/California/07/2009) in mice and ferrets. These results support the evaluation of this vaccine made from a wt strain isolated in China for clinical trials.
  43. ncbi Effect of the neuraminidase mutation H274Y conferring resistance to oseltamivir on the replicative capacity and virulence of old and recent human influenza A(H1N1) viruses
    Mariana Baz
    Research Center in Infectious Diseases of the Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada
    J Infect Dis 201:740-5. 2010
    ..Unexpectedly, an oseltamivir-resistant A(H1N1) variant containing the H274Y neuraminidase (NA) mutation recently disseminated worldwide, suggesting that the replication and virulence properties of this mutant virus were not compromised...
  44. ncbi Measurement of neutralizing antibody responses against H5N1 clades in immunized mice and ferrets using pseudotypes expressing influenza hemagglutinin and neuraminidase
    Cheguo Tsai
    The Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
    Vaccine 27:6777-90. 2009
    ..Thus, we conclude that the PN assay is a sensitive and quantifiable method to measure neutralizing antibodies against diverse clades and subclades of H5N1 influenza virus...
  45. ncbi The ferret auditory cortex: descending projections to the inferior colliculus
    Victoria M Bajo
    Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Cereb Cortex 17:475-91. 2007
    ..This pattern of corticocollicular connectivity is consistent with regional differences in physiological properties and provides another basis for subdividing ferret auditory cortex into functionally distinct areas...
  46. ncbi Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses
    Graeme E Price
    Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA
    Vaccine 27:6512-21. 2009
    ..to nucleoprotein (NP) and matrix 2 (M2) by DNA priming followed by parenteral or mucosal boosting in mice and ferrets. DNA vaccination followed by boosting with antigen-matched recombinant adenovirus (rAd) or cold-adapted (ca) ..
  47. ncbi H5N1 Virus Attachment to Lower Respiratory Tract
    Debby van Riel
    Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    Science 312:399. 2006
    ..These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion...
  48. pmc Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets
    Hui Ling Yen
    Department of Microbiology, HKU Pasteur Research Centre, University of Hong Kong, Pokfulam, Hong Kong SAR, China
    Proc Natl Acad Sci U S A 108:14264-9. 2011
    ..the pandemic H1N1 virus among humans, we evaluated the direct-contact and respiratory-droplet transmissibility in ferrets of representative swine influenza viruses of different lineages obtained through a 13-y surveillance program in ..
  49. pmc Vaccination against seasonal influenza A/H3N2 virus reduces the induction of heterosubtypic immunity against influenza A/H5N1 virus infection in ferrets
    R Bodewes
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, P O Box 2040, 3000 CA Rotterdam, Netherlands
    J Virol 85:2695-702. 2011
    ..Here we demonstrate that infection with a recent influenza A/H3N2 virus strain induces robust protection in ferrets against infection with a highly pathogenic avian influenza virus of the H5N1 subtype...
  50. ncbi A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Science 315:655-9. 2007
    ..to the avian alpha-2,3 sialic acid resulted in a virus incapable of respiratory droplet transmission between ferrets but that maintained its lethality and replication efficiency in the upper respiratory tract...
  51. pmc The descending corticocollicular pathway mediates learning-induced auditory plasticity
    Victoria M Bajo
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Nat Neurosci 13:253-60. 2010
    ..We examined the role of these neurons in experience-dependent recalibration of sound localization in adult ferrets by selectively killing the neurons using chromophore-targeted laser photolysis...
  52. pmc PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models
    Rong Hai
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029 6574, USA
    J Virol 84:4442-50. 2010
    ..Our results show enhanced replication of the 66S virus in A549 cells, while studies of BALB/c and DBA/2 mice and ferrets revealed no significant differences in symptoms of infection with wild-type Cal/09 versus the 66N or 66S virus ..
  53. ncbi Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction
    Nicholas Svitek
    INRS Institut Armand Frappier, University of Quebec, Laval, QC, Canada
    Virology 376:53-9. 2008
    Even though ferrets are one of the principal animal models for influenza pathogenesis, the lack of suitable immunological reagents has so far limited their use in host response studies...
  54. pmc Comparative analysis of the subventricular zone in rat, ferret and macaque: evidence for an outer subventricular zone in rodents
    Veronica Martinez-Cerdeno
    Department of Pathology and Laboratory Medicine, School of Medicine, University of California Davis, Sacramento, California, United States of America
    PLoS ONE 7:e30178. 2012
    ..We immunostained sections of the developing cerebral cortex from lissencephalic rats, and from gyrencephalic ferrets and macaques to compare the distribution of precursor cell types in each species...
  55. pmc Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus
    Iva Kelava
    Max Planck Institute of Molecular Cell Biology and Genetics, D 01307 Dresden, Germany
    Cereb Cortex 22:469-81. 2012
    ....
  56. pmc The multibasic cleavage site of the hemagglutinin of highly pathogenic A/Vietnam/1203/2004 (H5N1) avian influenza virus acts as a virulence factor in a host-specific manner in mammals
    Amorsolo L Suguitan
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:2706-14. 2012
    ..H5N1) or lacked (ΔH5N1) the H5 HA MBS were generated and evaluated for their virulence in BALB/c mice, ferrets, and African green monkeys (AGMs) (Chlorocebus aethiops)...
  57. pmc Sample size considerations for one-to-one animal transmission studies of the influenza A viruses
    Hiroshi Nishiura
    School of Public Health, The University of Hong Kong, Hong Kong SAR, China
    PLoS ONE 8:e55358. 2013
    ..The analyses are illustrated on transmission studies of influenza A viruses in the ferret model...
  58. pmc Cedar virus: a novel Henipavirus isolated from Australian bats
    Glenn A Marsh
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Australia
    PLoS Pathog 8:e1002836. 2012
    ..Preliminary challenge studies with CedPV in ferrets and guinea pigs, both susceptible to infection and disease with known henipaviruses, confirmed virus replication ..
  59. ncbi A sensitive retroviral pseudotype assay for influenza H5N1-neutralizing antibodies
    Nigel J Temperton
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London, United Kingdom
    Influenza Other Respir Viruses 1:105-12. 2007
    ..We have used retroviral pseudotypes bearing influenza H5 hemagglutinin (HA) as safe, surrogate viruses for influenza neutralization assays which can be carried out at Biosafety Level 2...
  60. pmc Interdependent encoding of pitch, timbre, and spatial location in auditory cortex
    Jennifer K Bizley
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 29:2064-75. 2009
    ..Such nonlinearities were most prevalent in primary auditory cortex, although they tended to be small compared with stimulus main effects...
  61. ncbi Local innate immune responses and influenza virus transmission and virulence in ferrets
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 205:474-85. 2012
    Host innate immunity is the first line of defense against invading pathogens, including influenza viruses. Ferrets are well recognized as the best model of influenza virus pathogenesis and transmission, but little is known about the ..
  62. ncbi The 2009 pandemic H1N1 D222G hemagglutinin mutation alters receptor specificity and increases virulence in mice but not in ferrets
    Yacine Abed
    Research Center in Infectious Diseases, CHUQ CHUL and Laval University, Quebec City, Canada
    J Infect Dis 204:1008-16. 2011
    ..We investigated the impact of this mutation in vitro and in animal models using recombinant pH1N1 viruses...
  63. pmc Avian influenza h6 viruses productively infect and cause illness in mice and ferrets
    Laura Gillim-Ross
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland 20892, USA
    J Virol 82:10854-63. 2008
    ..and their abilities to replicate and induce a cross-reactive immune response in two animal models: mice and ferrets. The different H6 viruses replicated to different levels in the respiratory tracts of mice and ferrets, causing ..
  64. pmc Assessment of the efficacy of the neuraminidase inhibitor oseltamivir against 2009 pandemic H1N1 influenza virus in ferrets
    Elena A Govorkova
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Antiviral Res 91:81-8. 2011
    ..Oseltamivir (25 mg/kg/day twice daily for 5 days) was orally administered to groups of ferrets, starting either 2 or 24 h after inoculation with 10(6)PFU of A/California/04/2009 (H1N1) influenza virus...
  65. ncbi Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys
    Jiang Fan
    Department of Vaccine and Biologics Research, Merck Research Laboratories, 770 Sumneytown Pike, P O Box 4, WP16 306, West Point, PA 19486, USA
    Vaccine 22:2993-3003. 2004
    ..to keyhole limpet hemocyanin (KLH) or Neisseria meningitidis outer membrane protein complex (OMPC)) in mice, ferrets, and rhesus monkeys...
  66. pmc Retinal origin of orientation maps in visual cortex
    Se Bum Paik
    Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Nat Neurosci 14:919-25. 2011
    ..we show that such a pattern is observed in individuals of four different species: monkeys, cats, tree shrews and ferrets. The proposed mechanism explains how orientation maps can develop without requiring precise patterns of ..
  67. pmc Comparative pathology in ferrets infected with H1N1 influenza A viruses isolated from different hosts
    Jennifer Humberd Smith
    Department of Infectious Diseases, Animal Health Research Center, University of Georgia, 111 Carlton Street, Athens, GA 30602, USA
    J Virol 85:7572-81. 2011
    Virus replication and pulmonary disease pathogenesis in ferrets following intranasal infection with a pandemic influenza virus strain (A/California/4/09 [CA09]), a human seasonal influenza H1N1 virus isolate (A/New Caledonia/20/99 [..
  68. pmc Insertion of a multibasic cleavage site in the haemagglutinin of human influenza H3N2 virus does not increase pathogenicity in ferrets
    Eefje J A Schrauwen
    National Influenza Center and Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Gen Virol 92:1410-5. 2011
    ..However, studies in ferrets demonstrated that insertion of the MBCS into HA did not result in increased virus shedding, cellular host range, ..
  69. ncbi Pandemic H1N1 influenza virus causes a stronger inflammatory response than seasonal H1N1 influenza virus in ferrets
    Young Myong Kang
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Gung Dong, Yuseong Gu, Daejeon, Korea
    Arch Virol 156:759-67. 2011
    ..To better understand the pathogenic mechanism, clinical signs and inflammatory responses in ferrets infected with the pandemic H1N1 were compared with those caused by seasonal H1N1 influenza virus...
  70. ncbi Cellular and network mechanisms of rhythmic recurrent activity in neocortex
    M V Sanchez-Vives
    Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nat Neurosci 3:1027-34. 2000
    ..The spontaneous generation and failure of this self-excited state may account for the generation of a subset of cortical rhythms during sleep...
  71. ncbi Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition
    Bilal Haider
    Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:4535-45. 2006
    ..in the prefrontal cortex in vivo, during the slow (<1 Hz) oscillation in ketamine-xylazine-anesthetized ferrets. We measured persistent network activity (Up states) with extracellular multiple unit and local field potential ..
  72. pmc Transcriptome sequencing and development of an expression microarray platform for the domestic ferret
    Carl E Bruder
    Southern Research Institute, Birmingham, AL 35205, USA
    BMC Genomics 11:251. 2010
    ..We present here a parallel sequencing effort to produce an extensive EST (expressed sequence tags) dataset derived from a normalized ferret cDNA library made from mRNA from ferret blood, liver, lung, spleen and brain...
  73. ncbi Molecular characterization of a novel coronavirus associated with epizootic catarrhal enteritis (ECE) in ferrets
    Annabel G Wise
    Diagnostic Center for Population and Animal Health, Lansing, MI 48909, USA
    Virology 349:164-74. 2006
    A novel coronavirus, designated as ferret enteric coronavirus (FECV), was identified in feces of domestic ferrets clinically diagnosed with epizootic catarrhal enteritis (ECE)...
  74. ncbi Efficacy of live attenuated influenza vaccine in children against influenza B viruses by lineage and antigenic similarity
    Robert B Belshe
    Saint Louis University Health Science Center, St Louis, MO 63104, USA
    Vaccine 28:2149-56. 2010
    ....
  75. ncbi A plant-produced influenza subunit vaccine protects ferrets against virus challenge
    Vadim Mett
    Fraunhofer USA Center for Molecular Biotechnology, Newark, DE, USA
    Influenza Other Respir Viruses 2:33-40. 2008
    ....
  76. pmc Design, assembly, and validation of a nose-only inhalation exposure system for studies of aerosolized viable influenza H5N1 virus in ferrets
    Richard S Tuttle
    Aerosol Research and Engineering Laboratories, 13300 West 98th Street, Lenexa, Kansas 66215, USA
    Virol J 7:135. 2010
    ..model that is a surrogate for humans, an inhalation exposure system for studies of aerosolized H5N1 viruses in ferrets was designed, assembled, and validated...
  77. pmc Impact of prior seasonal influenza vaccination and infection on pandemic A (H1N1) influenza virus replication in ferrets
    A H Ellebedy
    Department of Infectious Diseases, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 3678, USA
    Vaccine 29:3335-9. 2011
    ..inactivated vaccine (TIV) might be playing in this immunity we conducted a vaccination-challenge study in ferrets. Vaccination with TIV was unable to alter subsequent morbidity or contact transmission in ferrets following ..
  78. pmc Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferrets
    Matthew J Memoli
    Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 203:348-57. 2011
    ....
  79. pmc Genetic immunization in the lung induces potent local and systemic immune responses
    Kaimei Song
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:22213-8. 2010
    ..in a lethal challenge model, we show that aerosolized recombinant adenoviral immunization completely protects ferrets against H5N1 highly pathogenic avian influenza virus...
  80. pmc Evidence of human-to-swine transmission of the pandemic (H1N1) 2009 influenza virus in South Korea
    Min Suk Song
    College of Medicine and Medical Research Institute, Chungbuk National University, 12 Gaeshin Dong Heungduk Ku, Cheongju City, 361 763 Republic of Korea
    J Clin Microbiol 48:3204-11. 2010
    ..Animal studies (ferrets and mice) reveal that swine pandemic isolates epitomize biological properties attributed to the currently ..
  81. pmc Molecular characterization of in vivo adjuvant activity in ferrets vaccinated against influenza virus
    Yuan Fang
    Division of Immunology, International Institute of Infection and Immunity, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong 515041, People s Republic of China
    J Virol 84:8369-88. 2010
    ..adjuvant potential of CpG oligodeoxynucleotide (ODN) when used with a human seasonal influenza virus vaccine in ferrets. We found that the CpG ODN-adjuvanted vaccine effectively increased antibody production and activated type I ..
  82. ncbi The development of vaccine viruses against pandemic A(H1N1) influenza
    James S Robertson
    Division of Virology, National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar EN6 3QG, UK
    Vaccine 29:1836-43. 2011
    ..Two approaches were followed, the classical reassortment approach and the more recent reverse genetics approach. This report describes the development and the characteristics of current pandemic H1N1 candidate vaccine viruses...
  83. pmc Chloroquine administration does not prevent Nipah virus infection and disease in ferrets
    Jackie Pallister
    CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia
    J Virol 83:11979-82. 2009
    ..Chloroquine was assessed using a ferret model of lethal Nipah virus infection and found to be ineffective against Nipah virus infection in vivo...
  84. pmc Ferrets develop fatal influenza after inhaling small particle aerosols of highly pathogenic avian influenza virus A/Vietnam/1203/2004 (H5N1)
    John A Lednicky
    Energy and Life Sciences Division, Midwest Research Institute, 425 Volker Boulevard, Kansas City, Missouri 64110, USA
    Virol J 7:231. 2010
    ..b>Ferrets are often used as a animal model for humans in influenza pathogenicity and transmissibility studies...
  85. pmc Adaptation to stimulus statistics in the perception and neural representation of auditory space
    Johannes C Dahmen
    Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Neuron 66:937-48. 2010
    ..how auditory spatial processing adapts to stimulus statistics by presenting human listeners and anesthetized ferrets with noise sequences in which interaural level differences (ILD) rapidly fluctuated according to a Gaussian ..
  86. pmc Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets
    Natalia A Ilyushina
    Division of Virology, Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee, United States of America
    PLoS Pathog 6:e1000933. 2010
    ..None of the recombinant H5N1 viruses had attenuated virulence in ferrets inoculated with 10(6) EID(50) dose...
  87. pmc Possible increased pathogenicity of pandemic (H1N1) 2009 influenza virus upon reassortment
    Eefje J A Schrauwen
    National Influenza Centre and Erasmus Medical Center Department of Virology, Rotterdam, The Netherlands
    Emerg Infect Dis 17:200-8. 2011
    ..pandemic (H1N1) 2009 virus with respect to replication kinetics in vitro and pathogenicity and transmission in ferrets. Pandemic (H1N1) 2009 viruses containing basic polymerase 2 alone or in combination with acidic polymerase of ..
  88. ncbi Barrages of synaptic activity control the gain and sensitivity of cortical neurons
    Yousheng Shu
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 23:10388-401. 2003
    ..These results indicate that rapid increases in neuronal responsiveness, as well as increases in spike timing precision, can be achieved through balanced barrages of excitatory and inhibitory synaptic activity...
  89. pmc Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957
    Claudia Pappas
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    PLoS ONE 5:e11158. 2010
    ..HA and displayed dual binding to both alpha 2,6 and alpha 2,3 glycan receptors, transmitted efficiently to naïve ferrets by respiratory droplets...
  90. pmc Assessing the viral fitness of oseltamivir-resistant influenza viruses in ferrets, using a competitive-mixtures model
    Aeron C Hurt
    WHO Collaborating Centre for Reference and Research on Influenza, 10 Wreckyn St, North Melbourne, Victoria 3051, Australia
    J Virol 84:9427-38. 2010
    ..b>Ferrets were coinfected with either pure populations (100% susceptible wild-type or 100% oseltamivir-resistant mutant ..
  91. pmc Neural ensemble codes for stimulus periodicity in auditory cortex
    Jennifer K Bizley
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom, and Robotics, Brain, and Cognitive Sciences Department, Italian Institute of Technology, 16163 Genova, Italy
    J Neurosci 30:5078-91. 2010
    We measured the responses of neurons in auditory cortex of male and female ferrets to artificial vowels of varying fundamental frequency (f(0)), or periodicity, and compared these with the performance of animals trained to discriminate ..
  92. ncbi PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway
    A Robichaud
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, PO Box 1005, Pointe Claire, Dorval, Quebec, Canada H9R 4P8
    Neuropharmacology 40:262-9. 2001
    ..assess the role of alpha(2)-adrenoceptors in emesis induced by inhibitors of type 4 phosphodiesterase (PDE4) in ferrets. Pre-treatment with yohimbine, MK-912 or MK-467 (alpha(2)-adrenoceptor antagonists) caused sudden and unexpected ..
  93. ncbi Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Adv Virus Res 73:55-97. 2009
    ..As avian influenza viruses continue to cause human disease and death, animal pathogenesis studies identify avenues of investigation for novel preventative and therapeutic agents that could be effective in the event of a future pandemic...
  94. pmc Task difficulty and performance induce diverse adaptive patterns in gain and shape of primary auditory cortical receptive fields
    Serin Atiani
    Neuroscience and Cognitive Sciences Program, University of Maryland, College Park, MD 20742, USA
    Neuron 61:467-80. 2009
    ..These adaptive STRF changes were largest in high-performance sessions, confirming a close correlation with behavior...
  95. pmc Intranasal administration of alpha interferon reduces seasonal influenza A virus morbidity in ferrets
    Daniela Kugel
    Department of Virology, University of Freiburg, Freiburg, Germany
    J Virol 83:3843-51. 2009
    ..the protective potential of exogenous IFN-alpha against seasonal and highly pathogenic influenza viruses in ferrets. Intranasal treatment with IFN-alpha several hours before infection with the H1N1 influenza A virus strain A/USSR/..
  96. ncbi Ferrets as a transmission model for influenza: sequence changes in HA1 of type A (H3N2) virus
    M L Herlocher
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Infect Dis 184:542-6. 2001
    b>Ferrets were used as an animal model to study whether controlled transmission of type A influenza is similar to human transmission when sequence changes in HA1 are used as the outcome...
  97. pmc The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04
    Rachelle Salomon
    Department of Infectious Diseases, St Jude Children s Research Hospital, and Department of Pathology, University of Tennessee, Memphis, TN 38105, USA
    J Exp Med 203:689-97. 2006
    ..a fatal human case isolate, and nonlethal A/chicken/Vietnam/C58/04 (CH58) and tested their pathogenicity in ferrets and mice...
  98. ncbi The receptive-field organization of simple cells in primary visual cortex of ferrets under natural scene stimulation
    Darragh Smyth
    Laboratory of Physiology, Oxford University, Oxford OX1 3PT, United Kingdom
    J Neurosci 23:4746-59. 2003
    ..We recorded from simple cells in the primary visual cortex of anesthetized ferrets while stimulating with flashed digitized photographs of natural scenes...
  99. ncbi The contribution of sensory experience to the maturation of orientation selectivity in ferret visual cortex
    L E White
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 411:1049-52. 2001
    ..Orientation maps were present in dark-reared ferrets, but fully mature levels of tuning were never attained...
  100. ncbi Infection with human H1N1 influenza virus affects the expression of sialic acids of metaplastic mucous cells in the ferret airways
    S Kirkeby
    Dental School, Faculty of Health Sciences, University of Copenhagen, Denmark
    Virus Res 144:225-32. 2009
    Glycans terminating in sialic acids serve as receptors for influenza viruses. In this study ferrets were infected with influenza virus A/New Caledonia/20/99, and the in situ localization of sialic acids linked alpha2-3 and alpha2-6 in ..
  101. pmc The contribution of animal models to the understanding of the host range and virulence of influenza A viruses
    Christopher D O'Donnell
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Microbes Infect 13:502-15. 2011
    Since ferrets were first used in 1933 during the initial isolation of influenza A viruses, animal models have been critical for influenza research...

Research Grants64

  1. Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret Model
    Zoe Stewart; Fiscal Year: 2013
    ..However, CF ferrets have high perinatal mortality from abnormal intestinal and pancreatic function, altered glucose and lipid ..
  2. Liver disease in CF: CFTR controls innate immunity in biliary epithelium
    Mario Strazzabosco; Fiscal Year: 2013
    ..These studies will be performed in Cftr-defective mice and in ferrets, a novel CF model that spontaneously develops CFLD...
  3. Fatty Acid Defects &Oxidative Stress Modulate Islet Function in Cystic Fibrosis
    Aliye Uc; Fiscal Year: 2013
    ..birth, both models have abnormal insulin secretion, but the concomitant exocrine pancreatic disease is mild in CF ferrets and advanced in CF pigs...
  4. Peptide inhbitors of influenza entry-FAST TRACK
    Russell B Wilson; Fiscal Year: 2011
    ..This 16mer peptide, Flufirvitide-3, potently inhibited signs of influenza in ferrets, generally considered the best animal model for influenza...
  5. Pathological Evaluation of a Cystic Fibrosis Ferret Model
    John F Engelhardt; Fiscal Year: 2010
    ..Preliminary analysis of CFTR-deficient newborn ferrets demonstrates that they are afflicted by meconium ileus, defects in cAMP-mediated chloride transport in the airway ..
  6. Structural determinants of DTI observations in developing cortex and white matter
    Christopher D Kroenke; Fiscal Year: 2013
    ..to induce abnormal patterns of neural connections in the visual cortex of altricial species such as rodents and ferrets. We chose ferrets because they have a relatively large cerebral WM to gray matter (GM) ratio, which makes it ..
  7. Surrogate endpoints for correlating protective immunity in response to influenza
    Gary Fujii; Fiscal Year: 2010
    ..of our present proposal is to confirm that the L-IAVM2e1-HD vaccine will provide similar protective immunity in ferrets and non-human primates...
  8. Preclinical Development of m102.4, a Human Anti-Hendra and Nipah Antibody
    Timothy R Fouts; Fiscal Year: 2013
    ..4, that potently neutralizes all available NiV and HeV isolates in vitro and provided post-exposure protection of ferrets from NiV challenge and of African Green Monkeys (AGM) from HeV challenge. We believe that m102...
  9. Eritoran (E5564), a TLR4 antagonist, as a novel therapeutic for influenza
    Stefanie N Vogel; Fiscal Year: 2013
    ..against non-adapted human strains of virus and in a model of aged/immunocompromised animals, and finally, in ferrets, to confirm and extend the use of Eritoran using pandemic strains of influenza under ABSL3 conditions...
  10. Pandemic H5N1 vaccine containing recombinant H5 and a synthetic TLR4 agonist, GLA
    Christopher H Clegg; Fiscal Year: 2010
    ..If successful, then rH5+GLA adjuvant will be tested in virus challenge models by inoculating mice and ferrets with two strains of H5N1...
  11. rAAV-directed gene therapy to the lung in cystic fibrosis ferret models
    John F Engelhardt; Fiscal Year: 2013
    ..The CFTR-knockout ferrets demonstrate two lung colonization phenotypes that will be useful in developing therapies for CF-rapidly lethal ..
  12. Novel nanotechnology based oral influenza vaccines
    Sang Moo Kang; Fiscal Year: 2011
    ..In addition, we will evaluate the efficacy of oral vaccination in ferrets, which is a more relevant animal model for testing pre-clinical influenza vaccines for humans...
  13. Near-infrared laser to replace chemical vaccine adjuvant
    Satoshi Kashiwagi; Fiscal Year: 2013
    ..response to skin-based influenza vaccination using established animal models of influenza infection in mice and ferrets, 2) Elucidation of the cellula and molecular mechanisms of action of the NIR laser adjuvant in vitro and in vivo, ..
  14. Development of sG as a human vaccine against Nipah/Hendra
    Timothy R Fouts; Fiscal Year: 2013
    ..Immunization and challenge studies performed in cats, ferrets, and nonhuman primates using recombinant HeV soluble attachment protein G, HeV-sG, have demonstrated that a HeV-..
  15. Development of a novel adjuvant for vaccine sparing
    Hao Shen; Fiscal Year: 2013
    ..antibody and cellular responses after one immunization with the co-administered TIV flu vaccine in mice and ferrets using minimal immunogen consumption...
  16. Foundation Immunogens for Influenza Vaccines
    Eric A Weaver; Fiscal Year: 2013
    ..A final analysis will be done in ferrets, since ferrets more closely resemble natural influenza infection in humans...
  17. Virus-Like Particle Vaccine for SARS-CoV
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2010
    ..SARS-CoV VLP vaccines in BALB/c mice;and (3) to determine the potency of a VLP vaccine to protect BALB/c mice and ferrets challenged with live SARS-CoV...
  18. Development of Influenza Virus-Like Particle (VLP) Vaccines
    Innocent N Mbawuike; Fiscal Year: 2011
    ..dosage and adjuvant formulations for enhancement of vaccine potency and antigen sparing in preclinical studies in ferrets. C) Perform small scale cGMP vaccine production and toxicology studies for a Pre-Innovation Drug Application (IND)..
  19. IVIS Spectrum CT Imaging System in BSL-3 Containment
    KATHERINE D RYMAN; Fiscal Year: 2013
    ..anticipated use of the CVR/RBL laboratories includes pathogenesis and challenge studies in mice, rats, rabbits, ferrets and small NHPs, each of which are amenable to imaging in the IVIS Spectrum CT system...
  20. Neural Correlates of Streaming of Complex Sounds
    Shihab A Shamma; Fiscal Year: 2013
    ..The approach involves a combination of simultaneous single-unit recordings and behavioral tasks in ferrets, and psychophysical measures in humans...
  21. Transmissibility of avian influenza viruses in mammals
    Yoshihiro Kawaoka; Fiscal Year: 2013
    ..These mutant H5 HAs did not support virus transmission among ferrets (an established influenza virus transmission model) via respiratory droplets, but acquired this ability after two ..
  22. Transmissibility of avian influenza viruses in mammals
    Yoshihiro Kawaoka; Fiscal Year: 2012
    ..These mutant H5 viruses did not transmit among ferrets (an established influenza virus transmission model) via respiratory droplets (aerosols), but acquired this ..
  23. Influenza vaccines inducing broadly cross protective immunity
    Sang Moo Kang; Fiscal Year: 2013
    ..efficacy of promising vaccine candidates and the duration of cross protection will be further evaluated in ferrets, which is a more relevant animal model for testing pre-clinical vaccines for humans...
  24. Development of a Universal Influenza Seasonal Vaccine
    David B Weiner; Fiscal Year: 2013
    ..resulting in broad HI activity at protective levels (greater than 1/40 HI titers in an indicator animal species - Ferrets). Studies in ferrets will include challenge with pandemic as well as seasonal strains...
  25. Reagents for the analyses of CMI in the ferret influenza model.
    KAREN MARIE DUUS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Ferrets have the potential to become an important animal model of influenza infection, as they most closely demonstrate the disease symptoms and pathology that occurs in humans...
  26. Antigenic Relationships of SARS and Animal Coronaviruses
    Linda Saif; Fiscal Year: 2006
    ..SARS CoV experimentally infects macaques, ferrets and cats...
  27. Developing a Novel Mumps Virus Vaccine
    Biao He; Fiscal Year: 2013
    ..We propose to develop a novel mumps virus vaccine by attenuating virus through introducing mutations at desirable locations within the genome and to test immunogenicity of vaccine candidates in mice and ferrets.
  28. Boosting Flu Vaccination without Adjuvant Injection
    Mei X Wu; Fiscal Year: 2013
    ..Finally, we will extend the investigation to H5N1 pandemic flu vaccine, protecting mice and ferrets from a lethal challenge of a highly pathogenic avian H5N1 flu virus after one dose of the stockpiled H5N1 vaccine ..
  29. VLP Vaccine Technology
    Sang Moo Kang; Fiscal Year: 2013
    ..In the aim 3, we will extend the preclinical efficacy tests of VLP vaccines to cotton rats (RSV VLPs) and ferrets (novel universal influenza VLPs)...
  30. Omics-Based Predictive Modeling of Age-Dependent Outcome to Influenza Infection
    Elodie Ghedin; Fiscal Year: 2013
    ..We propose to use an age-dependent animal model (neonatal, adult and aged ferrets) and clinical human samples to collect biological measurements at multiple scales of host-virus interaction...
  31. Circuit mechanisms governing the development of direction selectivity
    GORDON BRAWN SMITH; Fiscal Year: 2013
    ..Furthermore, in visually naove ferrets brief exposure to a drifting grating stimulus (motion training) is sufficient to drive the emergence of direction ..
  32. Number Representation in Primates
    Elizabeth M Brannon; Fiscal Year: 2010
    ..Animal genera as diverse as rats, pigeons, ferrets, raccoons, monkeys, and apes have been shown to make numerical judgments with stimuli that include light flashes, ..
  33. The Effects of Antibodies on Vascular Permeability in Dengue Virus Infection
    Lindsey E Bazzone; Fiscal Year: 2013
    ..b>Ferrets that are either mock treated or treated with HMAbs will subsequently be challenged with DENV and assessed for ..
  34. CARDIAC & VASCULAR TOXICITY OF COCAINE
    James Morgan; Fiscal Year: 1991
    ..Electrical and mechanical studies will be performed with cardiac and vascular tissue from swine and ferrets that has been loaded with the calcium indicator aequorin to directly measure intracellular levels of free, ..
  35. BSL-3/ABSL-3 Expansion for Select Agent Translational Research
    Colleen Jonsson; Fiscal Year: 2010
    ..CPM) Regional Biocontainment Laboratory (RBL) to support work with select agents utilizing rodents, rabbits and ferrets as animal models in long term efficacy/product evaluation studies...
  36. MECHANISMS GOVERNING ONSET OF OVARIAN FUNCTION
    Kathleen Ryan; Fiscal Year: 1990
    ..The proximate cause of ovarian activation at puberty in ferrets and several other species is a marked decrease in the efficacy of estradiol to inhibit LH secretion...
  37. Development of a SARS Coronavirus Vaccine
    Jeffrey Ulmer; Fiscal Year: 2004
    ..the inactivated SARS-CoV vaccine under cGMP and complete a preclinical package, including efficacy studies in ferrets and monkeys, which will provide the basis for a subsequent clinical trial under Specific Aim 2...
  38. Peptide drugs against influenza virus
    Robert Garry; Fiscal Year: 2007
    ..Specific Aim 2 is to evaluate the efficacy of lead peptides in ferrets, the small animal model that best recapitulates human influenza virus pathogenesis...
  39. NATURAL AND INDUCED IMMUNITY AGAINST HELICOBACTER PYLORI
    Pierre Michetti; Fiscal Year: 2001
    ..In contrast, oral immunization in mice and ferrets with various H. pylori antigens can prevent and even cure Helicobacter infection, indicating that H...
  40. NATURAL AND INDUCED IMMUNITY AGAINST HELICOBACTER PYLORI
    Pierre Michetti; Fiscal Year: 2000
    ..In contrast, oral immunization in mice and ferrets with various H. pylori antigens can prevent and even cure Helicobacter infection, indicating that H...
  41. MECHANISM OF BACTERIAL SUPERINFECTION
    BARBARA SANFORD; Fiscal Year: 1991
    ..We have selected to use ferrets (Mustela putorius furo), which are small carnivores, because influenza in the ferret most resembles the disease ..
  42. CAROTENOID BINDING PROTEIN AND CAROTENOID METABOLISM
    Raj Lakshman; Fiscal Year: 2002
    ..Our ongoing studies in ferrets showed the following: 1. 0.5 percent taurocholate (TC) and 13...
  43. Lycopene Chemoprevention of Lung Cancer in Ferret
    Xiang Dong Wang; Fiscal Year: 2010
    ..and the prevention (or promotion) of premalignant and malignant lung lesions in smoke-exposed, carcinogen-treated ferrets;2) lycopene (or lycopene metabolites) inhibit lung carcinogenesis by up-regulating insulin-likegrowth factor ..
  44. Biologic Activity of Lycopene
    Xiang Dong Wang; Fiscal Year: 2002
    ..of lycopene in vitro in the tissue of smoke-exposed versus non smoke-exposed lung and prostate tissues of ferrets. These studies will provide important information for the potential future use of lycopene as cancer preventive ..
  45. BRUGIAN FILARIASIS IN THE FERRET
    CATHERINE CRANDALL; Fiscal Year: 1990
    ..3) To identify cytokines regulating eosinophil activity in infected ferrets by assays for chemotaxis/chemokinesis and by activation of adherence and cytotoxicity to microfilariae...
  46. EFFECT OF OXIDANT POLLUTANTS ON AIRWAY SECRETION
    MATTHEW MARIN; Fiscal Year: 1990
    ..Two experimental models will be employed: 1) explants of tracheal submucosal glands of ferrets; and 2) tantalum coated surface of pig trachea, in vivo (hillock experiments)...
  47. BEHAVIORAL EFFECTS OF SEX STEROIDS
    Michael Baum; Fiscal Year: 1999
    ..of olfactory bulb deafferentation on sexual partner preference in gonadectomized, steroid-treated male and female ferrets. He will also determine whether intracerebroventricular infusion of galanin or of a galanin antagonist modifies ..
  48. T5000 Diagnostic System in Ferret Model of Influenza
    Frederick Koster; Fiscal Year: 2009
    ..identify the earliest time and respiratory secretion site of viral detection by TIGER, we will test secretions of ferrets infected by intranasal H3N2 and H5N1 strains in the ABSL-3 laboratory at LRRI...
  49. DOES PULMONARY SURFACTANT REACT WITH INHALED POLLUTANTS?
    BARBARA FINLAYSON PITTS; Fiscal Year: 1993
    ..Questions to be addressed through in vivo studies include: (1) Are ferrets an appropriate animal model for oxidant inhalation? (2) Can reaction products characteristic of the PS-oxidant ..
  50. HORMONAL CONTROL OF DELAYED IMPLANTATION
    RODNEY MEAD; Fiscal Year: 1991
    ..I then propose to demonstrate by passive immunization of ferrets and spotted skunks, that antibodies to LIF will inhibit implantation...
  51. INTERPLAY BETWEEN THE HA AND NA OF INFLUENZA VIRUSES
    Larisa Gubareva; Fiscal Year: 2003
    ..determine how changes in the HA and/or NA of zanamivir-resistant mutants affect the virulence of such viruses in ferrets. The major strength of this application is (i) availability of well-characterized zanamivir-resistant mutants ..
  52. FACILITY FOR NON-HUMAN PRIMATES IN INFECTIOUS DIS RES
    RICHARD BRADBURY; Fiscal Year: 1993
    ..viruses and rotaviruses will be done in squirrel, owl, patas, rhesus, and African Green monkeys, and possibly ferrets. Studies with respiratory tract infections will, particularly, be focused on testing of candidate vaccine strains ..
  53. Structural correlates of rapid cortical plasticity
    Mriganka Sur; Fiscal Year: 2010
    ..two-photon laser scanning microscopy in vivo and in vitro, and viral expression of exogenous proteins, in ferrets and mice, to examine: (1) the time course of functional changes in the ferret visual cortex during the critical ..
  54. CWD--MODEL OF NVCJD AND LYMPHOID PATHOGENESIS IN TSE'S
    Edward Hoover; Fiscal Year: 2003
    ..In aim 2 therefore they will expose ferrets to infectious CWD prions orally and determine by sequential sampling whether PrPres is detectable in lymphoid ..
  55. JUVENILE LUNG--TOXICOLOGICAL MODEL FOR CHILDREN
    RONALD RASMUSSEN; Fiscal Year: 1992
    ..The experimental approach will be to expose neonate ferrets daily to moderate levels of NO2 or a model particulate until they reach adult size...
  56. Biodefense vaccine for pandemic influenza
    Lawrence Smith; Fiscal Year: 2005
    ..AIM 1: Vaccination of mice and ferrets with pDNAs encoding human NP(concensus) and S7(concensus) and the avian HA(A/Vietnam/1194/04) genes and challenge ..
  57. Epileptogenic Mechanisms in Developmental Malformations
    KIMBERLE JACOBS; Fiscal Year: 2005
    ..Because brain development in ferrets is immature at birth, deletion of selective cellular laminae can be achieved...
  58. Adenoviral Vector-based Pandemic Influenza Vaccine
    SURESH MITTAL; Fiscal Year: 2009
    ..Naive and primed inbred mice and outbred ferrets will be used for immunization and challenge trials to address the complex spectrum of immunity that would exist ..
  59. AFFERENTS TO LHRH NEURONS AND MAMMALIAN REPRODUCTION
    Joan King; Fiscal Year: 1992
    ..Animal models will include: - 1) spontaneous ovulators with a luteal phase, guinea pigs; 2) induced ovulators, ferrets; 3) seasonal ovulators, bats; and 4) once only ovulators, lamprey...
  60. MECHANISMS OF VISUAL CONTEXT EFFECTS IN VISUAL CORTEX
    Jonathan Levitt; Fiscal Year: 2003
    ..1) In electrophysiological and neuroanatomical experiments in adult monkeys and ferrets, we will test whether the spatial extent and topography of response suppression or enhancement from beyond the ..
  61. STRUCTURAL CORRELATES OF CORTICAL INFORMATION PROCESSING
    Sharon L Juliano; Fiscal Year: 2010
    ..cells? These studies will use organotypic cultures and transplantation of neural progenitor cells into neonatal ferrets. We expect these experiments to lead to novel ideas about factors mediating tangential migration of neurons ..
  62. MECHANISMS OF VISUAL SYSTEM MATURATION
    Vivien Casagrande; Fiscal Year: 1990
    ..Each of the specific aims is designed to test aspects of this model in the developing LGN of tree shrews and ferrets. SPECIFIC AIM 1 will determine whether the developmental sequence of growth of afferents and dendrites supports ..
  63. ACTIVITY DEPENDENT MECHANISMS OF VISUAL DEVELOPMENT
    Mriganka Sur; Fiscal Year: 2002
    ..of specific connections between retinal ganglion cell axons and cells of the lateral geniculate nucleus (LGN) in ferrets, during the sorting of retinogeniculate projections into on-center and off-center sublaminae...
  64. INTRINSIC NEURAL SIGNALING IN PRIMATE PREFRONTAL CORTEX
    LEONID KRIMER; Fiscal Year: 2002
    ..Experiments will be conducted initially in ferrets and then in nonhuman primates and in human temporal cortex surgically removed for the treatment of intractable ..