cats

Summary

Summary: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)

Top Publications

  1. ncbi Genotyping of Toxoplasma gondii isolates from cats in different geographic regions of China
    Z W Chen
    Department of Parasitology and Key Laboratories of Pathogen Biology and Zoonoses, Anhui Medical University, Hefei 230032, China
    Vet Parasitol 183:166-70. 2011
  2. ncbi Babesiosis in dogs and cats--expanding parasitological and clinical spectra
    Laia Solano-Gallego
    Department of Pathology and Infectious Diseases, Royal Veterinary College of London, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK
    Vet Parasitol 181:48-60. 2011
  3. ncbi Advances in the control of Ctenocephalides felis (cat flea) on cats and dogs
    Michael K Rust
    Department of Entomology, University of California, Riverside, CA 92521 0314, USA
    Trends Parasitol 21:232-6. 2005
  4. pmc Seroprevalence of Toxoplasma gondii infection in household and stray cats in Lanzhou, northwest China
    Song Ming Wu
    College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu Province, PR China
    Parasit Vectors 4:214. 2011
  5. pmc Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons
    A Destexhe
    Unite de Neurosciences Integratives et Computationnelles, CNRS, UPR 2191, Gif sur Yvette, France
    Neuroscience 107:13-24. 2001
  6. ncbi Natural waking and sleep states: a view from inside neocortical neurons
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 85:1969-85. 2001
  7. ncbi Spontaneously emerging cortical representations of visual attributes
    Tal Kenet
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 425:954-6. 2003
  8. pmc The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats
    Dorothee Stanneck
    Bayer Animal Health GmbH, Leverkusen, Germany
    Parasit Vectors 5:73. 2012
  9. ncbi Massive parallel 16S rRNA gene pyrosequencing reveals highly diverse fecal bacterial and fungal communities in healthy dogs and cats
    Stefanie Handl
    Department for Farm Animals and Veterinary Public Health, Institute of Animal Nutrition, University of Veterinary Medicine Vienna, Vienna, Austria
    FEMS Microbiol Ecol 76:301-10. 2011
  10. ncbi Effect of a multi-species synbiotic formulation on fecal bacterial microbiota of healthy cats and dogs as evaluated by pyrosequencing
    Jose F Garcia-Mazcorro
    Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A and M University, College Station, TX, USA
    FEMS Microbiol Ecol 78:542-54. 2011

Detail Information

Publications404 found, 100 shown here

  1. ncbi Genotyping of Toxoplasma gondii isolates from cats in different geographic regions of China
    Z W Chen
    Department of Parasitology and Key Laboratories of Pathogen Biology and Zoonoses, Anhui Medical University, Hefei 230032, China
    Vet Parasitol 183:166-70. 2011
    Fourteen isolates of Toxoplasma gondii were isolated from cats from 4 different geographic provinces (Anhui, Hubei, Shanxi and Guangdong) in China and their genetic diversity with 8 nuclear loci SAG2, SAG3, BTUB, GRA6, L358, PK1, c22-8, ..
  2. ncbi Babesiosis in dogs and cats--expanding parasitological and clinical spectra
    Laia Solano-Gallego
    Department of Pathology and Infectious Diseases, Royal Veterinary College of London, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK
    Vet Parasitol 181:48-60. 2011
    ..Babesiosis in domestic cats is less common and has mostly been reported from South Africa where infection is mainly due to Babesia felis, a ..
  3. ncbi Advances in the control of Ctenocephalides felis (cat flea) on cats and dogs
    Michael K Rust
    Department of Entomology, University of California, Riverside, CA 92521 0314, USA
    Trends Parasitol 21:232-6. 2005
    Cat fleas are the most important ectoparasite of cats and dogs worldwide...
  4. pmc Seroprevalence of Toxoplasma gondii infection in household and stray cats in Lanzhou, northwest China
    Song Ming Wu
    College of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu Province, PR China
    Parasit Vectors 4:214. 2011
    ..As the only definitive host, cats play a crucial role in the transmission of T. gondii infection by shedding parasite oocysts in their feces...
  5. pmc Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons
    A Destexhe
    Unite de Neurosciences Integratives et Computationnelles, CNRS, UPR 2191, Gif sur Yvette, France
    Neuroscience 107:13-24. 2001
    ..We conclude that many of the characteristics of cortical neurons in vivo can be explained by fast glutamatergic and GABAergic conductances varying stochastically...
  6. ncbi Natural waking and sleep states: a view from inside neocortical neurons
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medicine, Universite Laval, Quebec G1K 7P4, Canada
    J Neurophysiol 85:1969-85. 2001
    ..We investigated the incidence of different firing patterns in neocortical neurons of awake cats, the relation between membrane potential fluctuations and firing rates, and the input resistance during all states ..
  7. ncbi Spontaneously emerging cortical representations of visual attributes
    Tal Kenet
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 425:954-6. 2003
    ..dye imaging, we previously established a close link between ongoing activity in the visual cortex of anaesthetized cats and the spontaneous firing of a single neuron...
  8. pmc The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats
    Dorothee Stanneck
    Bayer Animal Health GmbH, Leverkusen, Germany
    Parasit Vectors 5:73. 2012
    The control of tick and flea burdens in dogs and cats has become essential to the control of important and emerging vector borne diseases, some of which are zoonoses...
  9. ncbi Massive parallel 16S rRNA gene pyrosequencing reveals highly diverse fecal bacterial and fungal communities in healthy dogs and cats
    Stefanie Handl
    Department for Farm Animals and Veterinary Public Health, Institute of Animal Nutrition, University of Veterinary Medicine Vienna, Vienna, Austria
    FEMS Microbiol Ecol 76:301-10. 2011
    This study evaluated the fecal microbiota of 12 healthy pet dogs and 12 pet cats using bacterial and fungal tag-encoded FLX-Titanium amplicon pyrosequencing...
  10. ncbi Effect of a multi-species synbiotic formulation on fecal bacterial microbiota of healthy cats and dogs as evaluated by pyrosequencing
    Jose F Garcia-Mazcorro
    Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A and M University, College Station, TX, USA
    FEMS Microbiol Ecol 78:542-54. 2011
    The effect of a multi-species synbiotic on the fecal microbiota of healthy cats (n = 12) and dogs (n = 12) was evaluated...
  11. ncbi Properties of somatosensory synaptic integration in cerebellar granule cells in vivo
    Henrik Jörntell
    Department of Experimental Medical Sciences, Section for Neuroscience, Biomedical Center F10, SE 221 84 Lund, Sweden
    J Neurosci 26:11786-97. 2006
    In decerebrated, nonanesthetized cats, we made intracellular whole-cell recordings and extracellular cell-attached recordings from granule cells in the cerebellar C3 zone...
  12. pmc European bat Lyssavirus transmission among cats, Europe
    Laurent Dacheux
    Institut Pasteur, Paris, France
    Emerg Infect Dis 15:280-4. 2009
    We identified 2 cases of European bat lyssavirus subtype 1 transmission to domestic carnivores (cats) in France. Bat-to-cat transmission is suspected. Low amounts of virus antigen in cat brain made diagnosis difficult.
  13. ncbi Receptive field plasticity profoundly alters the cutaneous parallel fiber synaptic input to cerebellar interneurons in vivo
    Henrik Jörntell
    Department of Physiological Sciences, Section for Neurophysiology, SE 221 84 Lund, Sweden
    J Neurosci 23:9620-31. 2003
    ..The CF response, which is crucial for the induction of the PF synaptic potentiation, was strong but variable and very different from the conventional EPSPs evoked by PFs...
  14. pmc A small world of neuronal synchrony
    Shan Yu
    Department of Neurophysiology, Max Planck Institute for Brain Research, D 60528 Frankfurt am Main, Germany
    Cereb Cortex 18:2891-901. 2008
    ..Visual responses were recorded in visual cortex of anesthetized cats, simultaneously from up to 24 neurons...
  15. ncbi New molecular data on mammalian Hepatozoon species (Apicomplexa: Adeleorina) from Brazil and Spain
    A Criado-Fornelio
    Laboratory of Parasitology, Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Alcala, 28871 Alcala de Henares, Spain
    J Parasitol 92:93-9. 2006
    ..isolated from 13 foxes and 15 opossums from Brazil, and from 15 dogs, 20 foxes, 45 rodents, and 330 domestic cats from Spain. Hemogregarine infection was confirmed by amplification of the 18S rRNA gene and later sequencing...
  16. ncbi Low seroprevalence of Leishmania infantum infection in cats from northern Portugal based on DAT and ELISA
    Luis Cardoso
    Department of Veterinary Sciences, University of Tras os Montes e Alto Douro, P O Box 1013, 5001 801 Vila Real, Portugal
    Vet Parasitol 174:37-42. 2010
    b>Cats have been considered playing a role in the epidemiology of leishmaniasis caused by Leishmania infantum, an endemic zoonosis in countries of the Mediterranean basin. The present study assessed the prevalence of antibodies to L...
  17. pmc Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto®) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe
    Dorothee Stanneck
    Bayer Animal Health GmbH BAH, Monheim, Germany
    Parasit Vectors 5:66. 2012
    ..imidacloprid/flumethrin collar (Seresto®, Bayer AnimalHealth, Investigational Veterinary Product(IVP)) in dogs and cats naturally infested with fleas and/or ticks in comparison to a dimpylat collar ("Ungezieferband fuer Hunde/fuer ..
  18. ncbi Toxoplasma gondii: epidemiology, feline clinical aspects, and prevention
    Stacey A Elmore
    Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Trends Parasitol 26:190-6. 2010
    Toxoplasma gondii is a parasite of birds and mammals. Cats are the only definitive host and thus the only source of infective oocysts, but other mammals and birds can develop tissue cysts...
  19. pmc Feline vector-borne pathogens in the north and centre of Portugal
    Hugo Vilhena
    Department of Veterinary Medicine, Escola Universitária Vasco da Gama, Coimbra, Portugal
    Parasit Vectors 6:99. 2013
    ..In recent years, several clinical cases and epidemiological studies of feline vector-borne diseases (FVBD) have been reported worldwide. Nonetheless, information on FVBD agents and their prevalence in Portugal is scarce...
  20. ncbi Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats
    Niels C Pedersen
    Center for Companion Animal Health, University of California, One Shields Avenue, Davis, CA 95616, USA
    Virus Res 165:17-28. 2012
    ..order to confirm these assumptions, 27 fecal and 32 FIP coronavirus isolates were obtained from resident or adopted cats from a large metropolitan shelter during 2008-2009 and their 3a-c, E, and M genes sequenced...
  21. ncbi Role of pet dogs and cats in the transmission of helminthic zoonoses in Europe, with a focus on echinococcosis and toxocarosis
    Peter Deplazes
    Institute of Parasitology, Vetsuisse Faculty, University of Zurich, Switzerland
    Vet Parasitol 182:41-53. 2011
    ..However, pet dogs and cats can play an important role in the transmission of helminthic zoonotic agents such as the tapeworms Echinococcus and ..
  22. pmc Stimulus contrast modulates functional connectivity in visual cortex
    Ian Nauhaus
    Biomedical Engineering Department, University of California Los Angeles, 405 Hilgard Avenue, Los Angeles, California 90095, USA
    Nat Neurosci 12:70-6. 2009
    ..Lateral connections dominate at low contrast, when spatial integration of signals is perhaps most beneficial...
  23. ncbi Specificity of the Toxoplasma gondii-altered behaviour to definitive versus non-definitive host predation risk
    P H L Lamberton
    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, UK
    Parasitology 135:1143-50. 2008
    ..Drug treatment of infected rats prevented any such host-specificity from being displayed. We discuss our results in terms of their potential implications both for T. gondii epidemiology and the evolution of parasite-altered behaviour...
  24. pmc Identification and classification of hubs in brain networks
    Olaf Sporns
    Department of Psychological and Brain Sciences and Program in Cognitive Science, Indiana University, Bloomington, Indiana, United States of America
    PLoS ONE 2:e1049. 2007
    ....
  25. ncbi Reciprocal bidirectional plasticity of parallel fiber receptive fields in cerebellar Purkinje cells and their afferent interneurons
    Henrik Jörntell
    Department of Physiological Sciences, Section for Neurophysiology, Lund University, The Biomedical Center F10, Tornavagen 10, SE 221 84, Sweden
    Neuron 34:797-806. 2002
    ..These properties, and the fact the mossy fiber receptive fields were unchanged, suggest that the receptive field changes were due to bidirectional PF synaptic plasticity in Purkinje cells and interneurons...
  26. ncbi Persistence and transmission of natural type I feline coronavirus infection
    D D Addie
    Department of Veterinary Pathology, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
    J Gen Virol 84:2735-44. 2003
    ..the mode of natural transmission and persistence of feline coronavirus (FCoV), FCoV strains shed by domestic cats were investigated over periods of up to 7 years...
  27. pmc Independent evolution of an antiviral TRIMCyp in rhesus macaques
    Sam J Wilson
    Medical Research Council Centre for Medical Molecular Virology, Department of Infection, Royal Free and University College Medical School, University College London, London W1T 4JF, United Kingdom
    Proc Natl Acad Sci U S A 105:3557-62. 2008
    ..The lack of activity against HIV-1 suggests that Mamu7 homozygous animals will be null for TRIM5-mediated restriction of HIV-1 and could contribute to improved animal models for HIV/AIDS...
  28. ncbi The late Miocene radiation of modern Felidae: a genetic assessment
    Warren E Johnson
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 1201, USA
    Science 311:73-7. 2006
    ..The phylogenetic performance of distinct gene classes showed that Y-chromosome segments are appreciably more informative than mitochondrial DNA, X-linked, or autosomal genes in resolving the rapid Felidae species radiation...
  29. ncbi Giardia in symptomatic dogs and cats in Europe--results of a European study
    C Epe
    Centre for Infectious Medicine, Institute for Parasitology, University of Veterinary Medicine Hannover, Germany
    Vet Parasitol 173:32-8. 2010
    The percentage of Giardia infection in dogs and cats with gastrointestinal signs presenting to clinics was examined across Europe using the IDEXX SNAP Giardia Test (IDEXX Laboratories)...
  30. ncbi A genetic linkage map of microsatellites in the domestic cat (Felis catus)
    M Menotti-Raymond
    Laboratory of Genomic Diversity, NCI FCRDC, Frederick, Maryland, 21702, USA
    Genomics 57:9-23. 1999
    ..The map has an average intragroup intermarker spacing of 11 cM and provides a valuable resource for mapping phenotypic variation in the species and relating it to gene maps of other mammals, including human...
  31. pmc Efficacy of indoxacarb applied to cats against the adult cat flea, Ctenocephalides felis, flea eggs and adult flea emergence
    Michael W Dryden
    Department of Diagnostic Medicine Pathobiology, Kansas State University, Manhattan, KS 66506, USA
    Parasit Vectors 6:126. 2013
    A study was conducted to evaluate the effect of indoxacarb applied to cats on adult cat fleas, Ctenocephalides felis, flea egg production and adult flea emergence.
  32. pmc Ticks and associated pathogens collected from dogs and cats in Belgium
    Edwin Claerebout
    Laboratory of Parasitology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Parasit Vectors 6:183. 2013
    ..are vectors of pathogens causing babesiosis, borreliosis, anaplasmosis, rickettsiosis and TBEV...
  33. pmc Endoparasite prevalence and recurrence across different age groups of dogs and cats
    Maureen C Gates
    University of Pennsylvania, School of Veterinary Medicine, 3800 Spruce St, Philadelphia, PA 19104, United States
    Vet Parasitol 166:153-8. 2009
    ..The apparent prevalence of endoparasite infections across different age groups was calculated from 6555 dogs and 1566 cats that had a fecal examination performed upon presentation to the Veterinary Hospital of the University of ..
  34. pmc Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts
    Karin C Lødrup Carlsen
    Department of Paediatrics, Oslo University Hospital, Ulleval, Norway
    PLoS ONE 7:e43214. 2012
    ..To examine the associations between pet keeping in early childhood and asthma and allergies in children aged 6-10 years...
  35. pmc Spike protein fusion peptide and feline coronavirus virulence
    Hui Wen Chang
    Virology Division, Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, Utrecht, The Netherlands
    Emerg Infect Dis 18:1089-95. 2012
    ..By these and perhaps other mutations, the virus apparently acquires its macrophage tropism and spreads systemically...
  36. pmc Specifying and sustaining pigmentation patterns in domestic and wild cats
    Christopher B Kaelin
    HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA
    Science 337:1536-41. 2012
    ..A similar range of patterns in domestic cats suggests a conserved mechanism whose appearance can be altered by selection...
  37. ncbi Intestinal and lung parasites in owned dogs and cats from central Italy
    Francesca Riggio
    Dipartimento di Patologia Animale, Profilassi e Igiene degli Alimenti, Facolta di Medicina Veterinaria, Universita di Pisa, Viale delle Piagge 2, 56124 Pisa, Italy
    Vet Parasitol 193:78-84. 2013
    Prevalence and risk factors of intestinal and lung parasites were investigated in 239 owned dogs and 81 owned cats from central Italy...
  38. ncbi Number and ownership profiles of cats and dogs in the UK
    J K Murray
    Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS40 5DU
    Vet Rec 166:163-8. 2010
    A random sample of 2980 households in the UK in 2007 showed that 26 per cent and 31 per cent of households owned cats and dogs, respectively. Households with gardens were more likely to own cats and dogs than households without gardens...
  39. ncbi Canine and feline infections by cardiopulmonary nematodes in central and southern Italy
    Angela Di Cesare
    Department of Comparative Biomedical Sciences, Faculty of Veterinary Medicine, Teramo, Italy
    Parasitol Res 109:S87-96. 2011
    ..abstrusus, Angiostrongylus vasorum and Dirofilaria immitis are cardiopulmonary nematodes affecting dogs and cats and presently emerging in several countries...
  40. ncbi Companion animals symposium: microbes and gastrointestinal health of dogs and cats
    J S Suchodolski
    Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4474, USA
    J Anim Sci 89:1520-30. 2011
    ..have revealed complex bacterial, fungal, archaeal, and viral communities in the gastrointestinal tract of dogs and cats. More than 10 bacterial phyla have been identified, with Firmicutes, Bacteroidetes, Proteobacteria, Fusobacteria, ..
  41. pmc Going wild: lessons from naturally occurring T-lymphotropic lentiviruses
    Sue Vandewoude
    Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, CO 80538 1619, USA
    Clin Microbiol Rev 19:728-62. 2006
    ..This comparison of consistent patterns in lentivirus biology will expose new directions for scientific inquiry for understanding the basis for virulence versus avirulence...
  42. ncbi Theoretical neuroanatomy: relating anatomical and functional connectivity in graphs and cortical connection matrices
    O Sporns
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Cereb Cortex 10:127-41. 2000
    ..We hypothesize that adaptation to rich sensory environments and motor demands requires complex dynamics and that these dynamics are supported by neuroanatomical motifs that are characteristic of the cerebral cortex...
  43. ncbi Simultaneous anterograde labeling of axonal layers from lateral superior olive and dorsal cochlear nucleus in the inferior colliculus of cat
    D L Oliver
    Department of Anatomy and Center for Neurological Sciences, University of Connecticut Health Center, Farmington 06030 3405, USA
    J Comp Neurol 382:215-29. 1997
    ..A second zone may contain inputs from the cochlear nucleus but lack those of the lateral superior olive...
  44. pmc Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease
    Jolanda D F de Groot-Mijnes
    Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    J Virol 79:1036-44. 2005
    ..Experimental FIP presents a relevant, safe, and well-defined model to study coronavirus-mediated immunosuppression and should provide an attractive and convenient system for in vivo testing of anticoronaviral drugs...
  45. pmc Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors
    Ajai Vyas
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:6442-7. 2007
    ..Proximate mechanisms of such behavioral manipulations remain unknown, although a subtle tropism on part of the parasite remains a potent possibility...
  46. pmc Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity
    Zuzana Keckesova
    Department of Infection, Royal Free and University College Medical School, University College London, Windeyer Building, 46 Cleveland Street, London W1T4JF, United Kingdom
    J Virol 80:4683-90. 2006
    ..We speculate that cyclophilin A alters HIV-1 sensitivity to a TRIM5alpha-independent innate immune pathway in human cells...
  47. pmc Inhibitory stabilization of the cortical network underlies visual surround suppression
    Hirofumi Ozeki
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Neuron 62:578-92. 2009
    ..We confirm two strong tests of this scenario experimentally and show through simulation that observed cell-to-cell variability in surround effects, from facilitation to suppression, can arise naturally from variability in the ISN...
  48. pmc Sensory transmission in cerebellar granule cells relies on similarly coded mossy fiber inputs
    Fredrik Bengtsson
    Section for Neurophysiology, BMC F10, Tornavagen 10, SE 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 106:2389-94. 2009
    ..The computational consequences of this are that it becomes possible for granule cells to also transmit weak sensory inputs in a graded fashion and to preserve the specific activity patterns of the mossy fibers...
  49. ncbi Zoonotic parasites in fecal samples and fur from dogs and cats in The Netherlands
    Paul A M Overgaauw
    RnA BV, Yalelaan 2, 3584 CM, Utrecht, The Netherlands
    Vet Parasitol 163:115-22. 2009
    ..Fecal and hair samples were collected from healthy household dogs and cats in Dutch veterinary practices. Owners were interviewed about interaction with their pets...
  50. ncbi Molecular identification of Giardia duodenalis isolates from humans, dogs, cats and cattle from the state of São Paulo, Brazil, by sequence analysis of fragments of glutamate dehydrogenase (gdh) coding gene
    Silvio L P Souza
    Departamento de Medicina Veterinaria Preventiva e Saude Animal, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Av Prof Dr Orlando Marques de Paiva 87, CEP 05508 900, Sao Paulo, SP, Brazil
    Vet Parasitol 149:258-64. 2007
    ..gdh) coding genes were obtained from cysts of Giardia duodenalis isolated from feces of naturally infected cats (n=19), dogs (n=27), humans (n=37) and cattle (n=5)...
  51. ncbi The molecular biology of coronaviruses
    Paul S Masters
    Wadsworth Center, New York State Department of Health, Albany, 12201, USA
    Adv Virus Res 66:193-292. 2006
    ....
  52. pmc Perceptual learning improves contrast sensitivity of V1 neurons in cats
    Tianmiao Hua
    Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027, China
    Curr Biol 20:887-94. 2010
    ..measurements with extracellular single-unit recording under anesthetized preparations and examined the effects of training in grating orientation identification on both perceptual and neuronal contrast sensitivity functions of cats.
  53. ncbi The veterinary and public health significance of hookworm in dogs and cats in Australia and the status of A. ceylanicum
    Carlysle S Palmer
    WHO Collaborating Centre for Molecular Epidemiology of Parasitic Infections, School of Veterinary and Biomedical Sciences and Western Australian State Agricultural Biotechnology Centre, Murdoch University, Perth, Australia
    Vet Parasitol 145:304-13. 2007
    There is no current information regarding the prevalence of hookworm in Australian dogs and cats and based on the results of studies conducted over 20 years ago, where high prevalences of helminths were recorded, the prophylactic ..
  54. ncbi Characterization of neutrophil extracellular traps in cats naturally infected with feline leukemia virus
    Amanda B Wardini
    Instituto de Veterinaria, Universidade Federal Rural do Rio de Janeiro, Seropedica, RJ, Brazil
    J Gen Virol 91:259-64. 2010
    Feline leukemia virus (FeLV), a common, naturally occurring gammaretrovirus in domestic cats, is associated with degenerative diseases of the haematopoietic system, immunodeficiency and neoplasia...
  55. pmc Lentiviral Vif degrades the APOBEC3Z3/APOBEC3H protein of its mammalian host and is capable of cross-species activity
    Rebecca S LaRue
    Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, and Comparative and Molecular Biology Graduate Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Virol 84:8193-201. 2010
    ..similarly promiscuous, degrading not only sheep A3Z3 but also the A3Z3-type proteins of humans, macaques, cows, and cats. In contrast to the neutralization capacity of these Vif proteins, human immunodeficiency virus (HIV), bovine ..
  56. ncbi Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex
    Kenichi Ohki
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 433:597-603. 2005
    ..These results indicate that cortical maps can be built with single-cell precision...
  57. ncbi Epidemiologic and zoonotic aspects of ascarid infections in dogs and cats
    Alice C Y Lee
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Campus Road, Ithaca, NY 14853, USA
    Trends Parasitol 26:155-61. 2010
    Toxocaracanis and Toxocara cati of dogs and cats, respectively, can cause significant disease in people...
  58. ncbi Isolation of relevant visual features from random stimuli for cortical complex cells
    Jon Touryan
    Group in Vision Science, University of California, Berkeley, California 94720, USA
    J Neurosci 22:10811-8. 2002
    ....
  59. ncbi Transmission of methicillin-resistant Staphylococcus pseudintermedius between infected dogs and cats and contact pets, humans and the environment in households and veterinary clinics
    E van Duijkeren
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, PO Box 80165, 3508 TD Utrecht, Netherlands
    Vet Microbiol 150:338-43. 2011
    ..Five of 14 (36%) contact dogs and four of 13 (31%) contact cats were found MRSP-positive...
  60. ncbi Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent
    M E Bruce
    Institute for Animal Health, BBSRC MRC Neuropathogenesis Unit, Edinburgh, UK
    Nature 389:498-501. 1997
    ..This BSE 'signature' has also been identified in transmissions to mice of TSEs of domestic cats and two exotic species of ruminant, providing the first direct evidence for the accidental spread of a TSE between ..
  61. ncbi Feline infectious peritonitis: insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene
    Hui Wen Chang
    Virology Division, Department of Infectious Diseases and Immunology, Veterinary Faculty, Utrecht University, Utrecht, The Netherlands
    J Gen Virol 91:415-20. 2010
    ..We analysed the 3c gene--a proposed virulence marker--in 27 FECV- and 28 FIPV-infected cats. Our findings suggest that functional 3c protein expression is crucial for FECV replication in the gut, but ..
  62. ncbi Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses
    H Vennema
    Center for Companion Animal Health, School of Veterinary Medicine, University of California at Davis, California 95616, USA
    Virology 243:150-7. 1998
    Feline infectious peritonitis virus (FIPV) strains from six cats and three different geographic areas were compared genetically with feline enteric coronavirus (FECV) isolates obtained from cats inhabiting the same environments...
  63. ncbi Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study
    T Platts-Mills
    University of Virginia Asthma and Allergic Diseases Center, University of Virginia Department of Medicine, Charlottesville, USA
    Lancet 357:752-6. 2001
    ..We investigated the immune response to cat and mite allergens, and asthma among children with a wide range of allergen exposure...
  64. ncbi Simulation of robustness against lesions of cortical networks
    Marcus Kaiser
    School of Computing Science, University of Newcastle, Claremont Tower, Newcastle upon Tyne NE1 7RU, UK
    Eur J Neurosci 25:3185-92. 2007
    ..This informs the understanding of the development of connectivity of the brain networks...
  65. ncbi Echinococcus multilocularis infections in domestic dogs and cats from Germany and other European countries
    Viktor Dyachenko
    Institute of Parasitology, University of Leipzig, An den Tierkliniken 35, 04103 Leipzig, Germany
    Vet Parasitol 157:244-53. 2008
    ..granulosus infections in domestic dogs and cats from Germany and other European countries...
  66. ncbi Spatial structure of complex cell receptive fields measured with natural images
    Jon Touryan
    Group in Vision Science, School of Optometry, University of California, Berkeley, CA 94720, USA
    Neuron 45:781-91. 2005
    ..The subunit RF model provides a useful basis for understanding cortical processing of natural stimuli...
  67. ncbi Ehrlichiosis and anaplasmosis in dogs and cats
    Susan E Little
    Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078 2007, USA
    Vet Clin North Am Small Anim Pract 40:1121-40. 2010
    ..the diversity of the rickettsial organisms responsible for ehrlichiosis and anaplasmosis in dogs and, occasionally, cats, the vectors capable of transmitting these agents, and the role these organisms play as both important veterinary ..
  68. ncbi Molecular and functional interactions of cat APOBEC3 and feline foamy and immunodeficiency virus proteins: different ways to counteract host-encoded restriction
    Sarah Chareza
    German Cancer Research Center DKFZ, Research Program Infection and Cancer, Heidelberg, Germany
    Virology 424:138-46. 2012
    ..Additionally, one-domain feA3 proteins can homo- and hetero-dimerize in vitro, but a trans-dominant phenotype of any of the low-activity feA3 forms on FFV restriction by one of the highly-active feA3Z2 proteins was not detectable...
  69. pmc Efficacy of an imidacloprid/flumethrin collar against fleas and ticks on cats
    Dorothee Stanneck
    Bayer HealthCare AG, Animal Health Division, D 51368 Leverkusen, Germany
    Parasit Vectors 5:82. 2012
    ..w/w) incorporated in a slow-release matrix collar, against laboratory-infestations of fleas and ticks on cats. Efficacy was evaluated against the flea Ctenocephalides felis felis, and the ticks Ixodes ricinus, Amblyomma ..
  70. ncbi Genetic diversity of Toxoplasma gondii isolates in Egyptian feral cats reveals new genotypes
    Y M Al-Kappany
    U S Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Building 1001, Beltsville, Maryland 20705 2350, USA
    J Parasitol 96:1112-4. 2010
    b>Cats are important in the epidemiology of Toxoplasma gondii because they are the only hosts that excrete environmentally resistant oocysts in feces. In the present study, 115 viable T...
  71. ncbi Results of parasitological examinations of faecal samples from cats and dogs in Germany between 2003 and 2010
    Dieter Barutzki
    Veterinary Laboratory Freiburg, Freiburg iBr, Germany
    Parasitol Res 109:S45-60. 2011
    In a retrospective study, the results of parasitological examinations of faecal samples from 8,560 cats and 24,677 dogs between January 2003 and December 2010 in Germany were analysed. 30.4 % of the examined dogs and 22...
  72. ncbi Can domestic cats be considered reservoir hosts of zoonotic leishmaniasis?
    Carla Maia
    Unidade de Parasitologia Médica, Centro de Malária e Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira, Portugal
    Trends Parasitol 27:341-4. 2011
    ..infantum, those regarding domestic cats deserve attention for the potential implications to public health...
  73. pmc Three pathogens in sympatric populations of pumas, bobcats, and domestic cats: implications for infectious disease transmission
    Sarah N Bevins
    USDA National Wildlife Disease Program, Fort Collins, Colorado, United States of America
    PLoS ONE 7:e31403. 2012
    ..Pumas, bobcats, and domestic cats are sympatric in many areas of North America and share many of the same pathogens, some of which are zoonotic...
  74. ncbi Isolation and characterization of Toxoplasma gondii strains from stray cats revealed a single genotype in Beijing, China
    Weifeng Qian
    Key Laboratory of Animal Epidemiology and Zoonosis, Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China
    Vet Parasitol 187:408-13. 2012
    b>Cats are essential in the epidemiology of Toxoplasma gondii because they are the only hosts that can excrete the environmentally resistant oocysts in nature...
  75. ncbi Vector-borne diseases in client-owned and stray cats from Madrid, Spain
    Tania Ayllon
    Departamento de Medicina y Cirugia Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avenida Puerta de Hierro s n, Madrid, Spain
    Vector Borne Zoonotic Dis 12:143-50. 2012
    The role of various vector-borne pathogens as a cause of disease in cats has not been clearly determined. The current study evaluated risk factors, clinical and laboratory abnormalities associated with Ehrlichia spp., Anaplasma spp...
  76. pmc Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region, China
    Proc Natl Acad Sci U S A 109:5435-40. 2012
    ..FmoPV RNA was detected in 56 (12.3%) of 457 stray cats (53 urine, four rectal swabs, and one blood sample) by RT-PCR...
  77. ncbi World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) second edition: guidelines for evaluating the efficacy of parasiticides for the treatment, prevention and control of flea and tick infestations on dogs and cats
    A A Marchiondo
    Zoetis Inc, formerly Pfizer Animal Health, 333 Portage Road, Kalamazoo, MI 49007, USA
    Vet Parasitol 194:84-97. 2013
    ..and conduct of laboratory and clinical studies to assess the efficacy of ectoparasiticides applied to dogs or cats for the purpose of treating, preventing and controlling flea and tick infestations...
  78. pmc Transmission of Bartonella henselae by Ixodes ricinus
    Violaine Cotte
    Institut National de la Recherche Agronomique, Maisons Alfort, France
    Emerg Infect Dis 14:1074-80. 2008
    ..b>Cats are the main reservoir for B. henselae and the bacteria are transmitted to cats by cat fleas...
  79. ncbi Prevalence of selected zoonotic and vector-borne agents in dogs and cats in Costa Rica
    Andrea V Scorza
    Veterinary Teaching Hospital, Colorado State University, 300 West Drake Road, Fort Collins, CO 80523, USA
    Vet Parasitol 183:178-83. 2011
    To estimate the prevalence of enteric parasites and selected vector-borne agents of dogs and cats in San Isidro de El General, Costa Rica, fecal and serum samples were collected from animals voluntarily undergoing sterilization...
  80. pmc Developing neocortex organization and connectivity in cats revealed by direct correlation of diffusion tractography and histology
    Emi Takahashi
    Division of Newborn Medicine, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cereb Cortex 21:200-11. 2011
    ..These results suggest that diffusion tractography can differentially characterize internal and external SP zones and their transition into mature cortical pathways...
  81. ncbi Cats and Toxoplasma: implications for public health
    H A Dabritz
    Infant Botulism Treatment and Prevention Program, California Department of Public Health, Richmond, CA 94804, USA
    Zoonoses Public Health 57:34-52. 2010
    b>Cats are popular as pets worldwide because they are easy to care for and provide companionship that enriches the lives of human beings...
  82. ncbi Population receptive fields of ON and OFF thalamic inputs to an orientation column in visual cortex
    Jianzhong Jin
    Department of Biological Sciences, State University of New York, College of Optometry, New York, New York, USA
    Nat Neurosci 14:232-8. 2011
    ..These results support developmental models of orientation maps that are based on the receptive field arrangement of ON and OFF visual inputs to cortex...
  83. pmc Feline immunodeficiency virus (FIV) as a model for study of lentivirus infections: parallels with HIV
    John H Elder
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    Curr HIV Res 8:73-80. 2010
    ..with HIV and thus serves well as a model for development of intervention strategies relevant to infection in both cats and man...
  84. ncbi Prevalence of flea infestation in dogs and cats in Hungary combined with a survey of owner awareness
    R Farkas
    Department of Parasitology and Zoology, Faculty of Veterinary Science, Szent Istvan University, Budapest, Hungary
    Med Vet Entomol 23:187-94. 2009
    ..was conducted in order to gain current information on flea species (Siphonaptera: Pulicidae) infesting dogs and cats living in urban and rural areas of Hungary, along with data on the factors that affect the presence, distribution ..
  85. pmc Pontine respiratory-modulated activity before and after vagotomy in decerebrate cats
    Thomas E Dick
    Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4941, USA
    J Physiol 586:4265-82. 2008
    ..were obtained before and after vagotomy and during delayed-I tests in decerebrate, paralysed and ventilated cats. In general, changes in activity pattern during the delayed-I tests were similar to those after vagotomy, with the ..
  86. ncbi Exposure to furry pets and the risk of asthma and allergic rhinitis: a meta-analysis
    B Takkouche
    Department of Preventive Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Allergy 63:857-64. 2008
    ..We sought to examine the association between exposure to furry pets and asthma and allergic rhinitis by means of a meta-analysis...
  87. ncbi Flea and tick control in the 21st century: challenges and opportunities
    Michael Wayne Dryden
    Department of Diagnostic Medicine Pathobiology, Kansas State University, Manhattan, KS 66506, USA
    Vet Dermatol 20:435-40. 2009
    ..such as fipronil, imidacloprid, nitenpyram and selamectin, have had a positive clinical effect on dogs and cats with FAD...
  88. ncbi Genetic diversity and introgression in the Scottish wildcat
    M Beaumont
    Institute of Zoology, Zoological Society of London, Regents Park, London NW 1RY, UK
    Mol Ecol 10:319-36. 2001
    This paper describes a genetic analysis of wild-living cats in Scotland. Samples from 230 wild-living Scottish cats (including 13 museum skins) and 74 house cats from England and Scotland were surveyed for nine microsatellite loci...
  89. ncbi Temporal precision in the neural code and the timescales of natural vision
    Daniel A Butts
    School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 449:92-5. 2007
    ....
  90. pmc The effects of toxoplasma infection on rodent behavior are dependent on dose of the stimulus
    A Vyas
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Neuroscience 148:342-8. 2007
    ..This report also demonstrates that toxoplasma affects emotional valence of the cat odor as indicated by altered learned fear induced by cat odor...
  91. ncbi Tritrichomonas foetus and not Pentatrichomonas hominis is the etiologic agent of feline trichomonal diarrhea
    Michael G Levy
    Department of Farm Animal and Health Resource Management, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, North Carolina 27606 1499, USA
    J Parasitol 89:99-104. 2003
    Recently, several investigators have reported large-bowel diarrhea in cats associated with intestinal trichomonad parasites...
  92. ncbi Visual cortex neurons of monkeys and cats: temporal dynamics of the spatial frequency response function
    Robert A Frazor
    Department of Psychology and Center for Perceptual Systems, University of Texas, Austin, TX 78712, USA
    J Neurophysiol 91:2607-27. 2004
    ....
  93. ncbi Emerging arthropod-borne diseases of companion animals in Europe
    Frederic Beugnet
    Meria Animal Health, 69007, Lyon, France
    Vet Parasitol 163:298-305. 2009
    ..Here, after consideration of the main reasons for changes in tick vector ecology, an overview of each "emerging" vector-borne diseases of pets is presented...
  94. pmc Acquisition of macrophage tropism during the pathogenesis of feline infectious peritonitis is determined by mutations in the feline coronavirus spike protein
    Peter J M Rottier
    Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands
    J Virol 79:14122-30. 2005
    ..The implications of these findings are discussed...
  95. pmc One health: the importance of companion animal vector-borne diseases
    Michael J Day
    School of Veterinary Sciences, University of Bristol, Langford BS40 5DU, UK
    Parasit Vectors 4:49. 2011
    ..One Health and specifically addresses the major vector-borne infectious diseases that are shared by man, dogs and cats. The most significant of these are leishmaniosis, borreliosis, bartonellosis, ehrlichiosis, rickettsiosis and ..
  96. ncbi Spectrotemporal receptive fields in the lemniscal auditory thalamus and cortex
    Lee M Miller
    W M Keck Center for Integrative Neuroscience, University of California Medical Center, San Francisco, CA 94143, USA
    J Neurophysiol 87:516-27. 2002
    ..By comparing simultaneously along multiple stimulus dimensions in both stations, these observations establish the global characteristics of the thalamocortical receptive field transformation...
  97. ncbi Prevalence of methicillin-resistant Staphylococcus aureus among staff and pets in a small animal referral hospital in the UK
    Anette Loeffler
    Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, London, UK
    J Antimicrob Chemother 56:692-7. 2005
    ....
  98. ncbi Cellular mechanisms of the slow (<1 Hz) oscillation in thalamocortical neurons in vitro
    Stuart W Hughes
    School of Biosciences, Cardiff University, Museum Avenue, CF10 3US, Cardiff, United Kingdom
    Neuron 33:947-58. 2002
    ..These results suggest an active role for the thalamus in shaping the slow (<1 Hz) sleep rhythm...
  99. ncbi Use of CD134 as a primary receptor by the feline immunodeficiency virus
    Masayuki Shimojima
    Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Science 303:1192-5. 2004
    Feline immunodeficiency virus (FIV) induces a disease similar to acquired immunodeficiency syndrome (AIDS) in cats, yet in contrast to human immunodeficiency virus (HIV), CD4 is not the viral receptor...
  100. ncbi Virulence differences between two field isolates of feline immunodeficiency virus (FIV-APetaluma and FIV-CPGammar) in young adult specific pathogen free cats
    N C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Immunol Immunopathol 79:53-67. 2001
    ..of this study was to identify a strain of feline immunodeficiency virus (FIV) that would be more virulent for adult cats than the prototype FIV-APetaluma and, thereby, enhance the FIV infection model for HIV-1 related research...
  101. pmc Description of outcomes of experimental infection with feline haemoplasmas: copy numbers, haematology, Coombs' testing and blood glucose concentrations
    Severine Tasker
    School of Clinical Veterinary Science, University of Bristol, Langford, Bristol BS40 5DU, United Kingdom
    Vet Microbiol 139:323-32. 2009
    The aim of this study was to compare blood copy, haematological and glucose values between cats experimentally infected with either Mycoplasma haemofelis (Group HF: 10 cats), 'Candidatus M...

Research Grants80

  1. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..The first uses phenylbiguanide (PBG) in chloralose anesthetized cats to stimulate 5- hydroxytryptamine-3 (5-HT3) cardiopulmonary receptors to reflexly lower heart rate and blood ..
  2. SARS-CoV Pathogenic Mechanisms in Senescent Mice
    Ralph S Baric; Fiscal Year: 2012
    ..Syndrome Coronavirus (SARS-CoV) is a zoonotic pathogen that likely emerged from bats, was amplified in civet cats and raccoon dogs and then transmitted to humans causing severe acute respiratory disease, pneumonia, and high ..
  3. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    Katherine P Ponder; Fiscal Year: 2013
    ..Another problem is that administration of this vector to adult MPS I mice or newborn MPS I cats resulted in a potent cytotoxic T lymphocyte (CTL) response that destroyed transducer cells...
  4. NITRIC OXIDE SYNTHASE IN THE JUXTAGLOMERULAR APPARATUS
    Christopher S Wilcox; Fiscal Year: 2013
    ..metabolized by dimethylarginine dimethylaminohydrolases (DDAHs) and exported by cationic amino acid transporters (CATs)...
  5. ROLE OF NITRIC OXIDE IN INTERSTITIAL CYSTITIS
    Lori A Birder; Fiscal Year: 2013
    ..There is a comparable disease in domestic cats termed feline interstitial cystitis (FIC), which demonstrates nearly all of the characteristics and symptoms of ..
  6. Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat Model
    GREGORY TODD PHARR; Fiscal Year: 2010
    ..Very high rates of placental and fetal infection occur in cats experimentally infected with FIV-B-2542, and reproductive failure is frequent at early and late-term pregnancy...
  7. Novel Therapies and Biomarkers for the Mucopolysaccharidoses
    CALOGERA MARIA SIMONARO; Fiscal Year: 2013
    ..and synovial fluid as sources of biomarkers for the MPS disorders by a) obtaining these materials from MPS VI cats of various stages of disease severity, and comparing the levels of several pro-inflammatory/pro-apoptotic proteins ..
  8. Neurotransplantation and Training to Promote Recovery of Chronic SCI Cats
    Michel A Lemay; Fiscal Year: 2013
    ..Recently we replicated this rat acute PNG approach in cats where we observed thousands of axons regenerating into the graft, a small percentage of which extended from the ..
  9. Bilateral cochlear implants: Physiology and psychophysics
    Bertrand Delgutte; Fiscal Year: 2012
    ..human subjects will be conducted in parallel with single-unit recordings from the inferior colliculus of deaf cats implanted bilaterally with intracochlear electrode arrays...
  10. Unihemispheric sleep: implications for mechanisms of sleep control and function i
    Jerome M Siegel; Fiscal Year: 2013
    ..supported work on sleep in mammals other than the already well understood "standard lab mammals," mostly rodents, cats and primates...
  11. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
    ..we will perform neurobehavioral analyses characterizing nociceptive and other sensory modality responses in cats together with evaluating the systemic effects of viral infection...
  12. LPL-Deficient Cats-A Quantitative Model of Gene Delivery
    PHILIP RICHARD VULLIET; Fiscal Year: 2010
    ..This disease is termed "familial chylomicronemia" in humans. LPL-/- cats share the identical mutation and cannot hydrolyze chylomicrons resulting in identical aberrations of their plasma ..
  13. Hematological consequences of FLVCR, a cytoplasmic heme export protein
    Janis L Abkowitz; Fiscal Year: 2013
    ..b>Cats viremic with Feline leukemia virus, subgroup C (FeLV-C) down-regulate the cell surface expression of FLVCR and ..
  14. FIV Testing of a CNS-Relevant Antiretroviral Compound
    Rick B Meeker; Fiscal Year: 2013
    ..The proposed studies are designed to accomplish four goals: 1) Establish safety and pharmacokinetics of FX101 in cats, including penetration into the CNS...
  15. Genetic components influencing the feline - human social bond
    Leslie A Lyons; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The role of domestic cats in animal-assisted interventions (AAI) has been well- recognized in nursing care for decades, especially improving the quality of life for the elderly, dementia patients, and ..
  16. Gene Therapy for Neurodegenerative Lysosomal Storage Diseases
    Douglas R Martin; Fiscal Year: 2013
    ..In Aim 2 long-term studies of therapeutic efficacy in GM1 cats and mice will be conducted using clinical, behavioral, and biochemical assays of disease progression...
  17. Genes, Home Allergens and Asthma in Puerto Rican Children
    JUAN CARLOS CELEDON; Fiscal Year: 2010
    ..We will then examine whether parental report of exposure to each of two pets (dogs and cats) in early life is associated with reduced risks of asthma (in all subjects) and atopy (separately in cases and in ..
  18. Role of Nitric Oxide in Feline Interstitial Cystitis.
    Lori Birder; Fiscal Year: 2009
    ..There is a comparable disease in domestic cats termed feline interstitial cystitis (FIC), which demonstrates nearly all of the characteristics and symptoms of ..
  19. Cognitive Behavioral Effects on Sleep, Pain, and Cytokines in Gynecologic Cancer
    Deidre B Pereira; Fiscal Year: 2013
    ..Grounded within the Central Arousal Theory of Stress (CATS) and a biobehavioral model of tumor biology, the central hypothesis of this application is that a CBT intervention ..
  20. Development of an in vivo model of chlamydial persistence.
    Robert V Schoborg; Fiscal Year: 2010
    ..Additional investigations using C. muridarum-infected mice and C. psittaci- infected cats suggest that amoxicillin/clavulonate (Amox/Clav)-exposed animals develop persistent infection...
  21. In vivo magnetic resonance-based analysis of inherited neurologic disease after g
    HEATHER G EDWARDS; Fiscal Year: 2013
    ..resonance imaging (MRI) to effectively evaluate disease progression (or retention of function) in gangliosidosis cats with or without AAV treatment. Aim...
  22. Comparative Genetics of Sweet Taste in Carnivora
    Peihua Jiang; Fiscal Year: 2013
    ..range of sweet taste behavior and because preliminary results suggest a mechanism for these species differences: cats do not like sugar and also have a microdeletion in one subunit of the sweet receptor gene that renders it ..
  23. The role of PPAR{gamma} ligands in corneal wound healing and optics
    Krystel R Huxlin; Fiscal Year: 2013
    ..We will perform binocular PRK in cats followed by the topical administration of select PPAR3 ligands, anti-TGF2 antibodies, steroids or Mitomycin C...
  24. The role of chemokines in cumulus oocyte expansion (C-OE) and oocyte maturation
    MARINA CINTHIA PELUFFO; Fiscal Year: 2013
    ..The PI's preliminary results from domestic cats demonstrated that the chemokine MCP-1 and its receptor (CCR2) are expressed in the oocyte and cumulus cells of COCs ..
  25. Cat allergen-human Fc-gamma1 chimeric proteins to treat cat allergy
    NOLAN contact SIGAL; Fiscal Year: 2010
    ..With nearly 78 million cats in the US and 40% of asthmatics sensitive to Fel d1, exposure to cat dander is a major contributor to the high ..
  26. EPIDEMIOLOGY AND ERADICATION OF MRSA IN HOUSEHOLDS WITH CHILDREN
    STEPHANIE ANN FRITZ; Fiscal Year: 2013
    ..Commonly handled household objects and surfaces, and pet dogs and cats, will be cultured...
  27. Feline Leukemia Virus C Receptor Heme Export and Erythroid Differentiation
    SIOBAN BRIDGET KEEL; Fiscal Year: 2010
    ..b>Cats naturally or experimentally infected with feline leukemia virus, subgroup C (FeLV-C) develop profound pure red cell ..
  28. Spinal Cord Injury, Plasticity and Transplant Mediated Repair
    John D Houle; Fiscal Year: 2013
    ..These studies then will be advanced into a cat model of SCI. Project 4 will use spinalized cats to test whether transplant-derived neurotrophins modify excitability of afferent pathways during locomotion and ..
  29. Development of sG as a human vaccine against Nipah/Hendra
    Timothy R Fouts; Fiscal Year: 2013
    ..Immunization and challenge studies performed in cats, ferrets, and nonhuman primates using recombinant HeV soluble attachment protein G, HeV-sG, have demonstrated that ..
  30. Quantifying cognitive-motor decline in FIV-infected cats
    Lola C Hudson; Fiscal Year: 2010
    ..We have developed a protocol to increase CNS FIV viral burden in the cats to facilitate CNS disease progression...
  31. AAV-mediated gene therapy for GM2-gangliodoses
    MIGUEL S ESTEVES; Fiscal Year: 2012
    ..In GM2 cats, we will first test the stability of the therapeutic effect of the new AAV vector formulation injected bilaterally ..
  32. Parasite / host interaction and the neurobiology of fear
    Robert M Sapolsky; Fiscal Year: 2012
    ..the capacity to, once having formed cysts in the brain, abolish the innate fear that rodents have of the odors of cats, and to convert that fear into an attraction;this increases the likelihood of the rodent being predated, thereby ..
  33. Metabolite effects on Group III and IV afferents
    MARC PETER KAUFMAN; Fiscal Year: 2013
    ..Dynamic exercise will be induced in decerebrated unanesthetized cats by electrical and possibly chemical stimulation of the mesencephalic or subthalamic locomotor regions...
  34. Intrathecal cyclodextrin therapy of feline Niemann-Pick type C disease
    Charles H Vite; Fiscal Year: 2013
    ..of children with NPC disease based on favorable treatment outcome data in subcutaneously treated npc1-/- mice and cats. However, due to the small patient sample size and the inability to undertake control studies in normal children ..
  35. China Adherence through Technology Study (CATS)
    Lora Sabin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): China Adherence through Technology Study (CATS) Effective highly active antiretroviral therapy (ART) requires strict adherence to dosing regimens...
  36. Structural and Functional Characterization of a Novel Model for Glaucoma Research
    GILLIAN JANE MCLELLAN; Fiscal Year: 2012
    ..rigorous clinical, functional and morphological characterization of primary glaucoma within this pedigree of cats. Over the first 3 years of the project, a cohort of cats will be evaluated longitudinally by both non-invasive ..
  37. MOLECULAR CHARACTERIZATION OF FIV
    John H Elder; Fiscal Year: 2013
    ..Sera from Progressor and Non-progressor cats will be analyzed against an overlapping peptide library to map epitopes recognized by infected cats as a function ..
  38. Estimating the Causal Effect of Interacting with Pet Dogs and Cats
    JEREMY NOWELL VILLETTE MILES; Fiscal Year: 2011
    ..In 2003, CHIS surveyed 42,000 adults and asked about dogs and cats living in their households...
  39. Probing dopamine D2 receptor trafficking in schizophrenia
    Anissa Abi-Dargham; Fiscal Year: 2013
    ..This "late phase" decrease (e4 hr after amphetamine) in BPND has been observed across species including rodents, cats, monkeys and humans...
  40. Enabling forelimb function with agonist drug and epidural stimulation in SCI
    Daniel Lu; Fiscal Year: 2013
    ..We have demonstrated that the physiological state of the lumbosacral spinal circuitry of spinal rats and cats can be modulated with spinal cord epidural stimulation (EDS) and/or administration of pharmacological agents to ..
  41. Recombinant Lactobacillus as an Oral Mucosal Vaccine Against HIV-1
    Gregg A Dean; Fiscal Year: 2012
    ..gasseri can induce protective immunity. These studies will be performed using the cat/FIV model of HIV-1 since cats have oropharyngeal mucosa associated lymphoid tissue similar to humans, can be economically studied using ..
  42. Analysis of Toxoplasma sexual development in polarized cat intestinal cells
    Laura J Knoll; Fiscal Year: 2013
    ..Curretly, only a limited number of sexual crosses of T. gondii are performed because they must occur in live cats after feeding them infected mouse brains and collecting their feces 3-10 days after infection...
  43. Protective CMI mechanisms of a dual-subtype FIV vaccine
    Janet K Yamamoto; Fiscal Year: 2012
    ..The mechanisms of dual-subtype FIV vaccine protection in cats should provide insights to the development of effective HIV-1/AIDS vaccine in humans...
  44. Computer Adaptive Testing Methods
    BARTH BRIAN RILEY; Fiscal Year: 2010
    ..age, gender, race, primary substance). The proposed project seeks to develop a coherent methodology for creating CATs for standardized biopsychosocial assessments that is applicable to diverse populations and effectively addresses ..
  45. Fatigue and Lifestyle Physical Activity in SLE
    Rosalind Ramsey-Goldman; Fiscal Year: 2012
    ..In addition, we propose to measure covariates of fatigue using computerized adaptive tests (CATs) patient-reported outcomes (PROs) that have been developed using state-of-the-art cognitive, qualitative, ..
  46. Gene Transfer and NMR Studies in Alpha-Mannosidosis Brain
    John H Wolfe; Fiscal Year: 2013
    ..Clinically, the treated AMD cats showed promising improvements in the neurological syndrome, but not complete resolution...
  47. Transmission-blocking live vaccine for Chagas disease
    Rick L Tarleton; Fiscal Year: 2013
    ..cruzi infected dogs or cats in the home...
  48. Neuroplasticity of Urinary Tract Disorders after SCI
    William C DeGroat; Fiscal Year: 2010
    ..techniques to examine the spinal organization and properties of these reflexes in normal, acute and chronic SCI cats and the mechanism underlying the spinal interactions between somatic and parasympathetic afferent inputs...
  49. Development of Molecular Imaging Technology Visualizing Viral Reservoirs in Vivo
    Won Bin Young; Fiscal Year: 2013
    ..Before applying to much more expensive SIV/monkey model, in Aim 2, we will inoculate cats with the engineered FIV constructs as a pilot experiment to evaluate the imaging technology in vivo to reveal the ..
  50. CORE GRANT FOR VISION RESEARCH
    Curtis R Brandt; Fiscal Year: 2013
    ..the effects of their infectious agents, drugs, manipulations, and vectors/constructs on ocular function in rodents, cats, rabbits and primates. During the previous funding period a total of 28 qualifying NEI grants were assisted...
  51. Repairing maladaptive corticospinal tract development
    John H Martin; Fiscal Year: 2013
    ..We will assay changes in connectivity and function in awake behaving cats using chronic electrophysiological recording techniques we have developed...
  52. Referral Center-Animal models of human genetic disease
    Mark E Haskins; Fiscal Year: 2013
    ..We will also serve as a resource for normal dogs and cats and their tissues, and we will continue to offer a facility and expertise for investigators to perform pathogenetic ..
  53. Evolution of Dendritic Cell Dysfunction in FIV Infection
    TRACY L WEBB; Fiscal Year: 2012
    ..1) to determine the time course and mechanisms of altered bone marrow(BM)-derived mDC function in FIV-infected cats, (2) to determine whether ex vivo manipulation of BM-derived mDCs from FIV-infected cats can restore function and ..
  54. Evaluation of Fecal Salmonella Carriage in Symptomatic and Asymptomatic Dogs in t
    Timothy Baszler; Fiscal Year: 2012
    ..main source of Salmonella infection in humans, non-food Salmonella sources can include pets (particularly dogs and cats), as well as their foods, snacks, and supplements...
  55. Genetic Mapping Resources for Common Mammalian Diseases
    Leslie A Lyons; Fiscal Year: 2013
    ..phenotypic and health information registry that will collect cat health data and provide DMA resources for the same cats. The project is relevant as it will generate genetic resources and models focusing on diseases that are difficult ..
  56. AIDS Lentivirus-induced TGF-beta+ Treg cells Mediate T cell Immune Dysfunction
    Mary B Tompkins; Fiscal Year: 2012
    ..and functionally (inhibition of ConA-induced proliferation and IL2 by CD4+ Th cells and IFN-3 by CD8+ T cells) in cats acutely infected with the NCSU1 isolate of FIV...
  57. Miniaturized Laser Sources for Optical Neuroprostheses
    MATTHEW DUMMER; Fiscal Year: 2012
    ..demonstrated by Northwestern University and Lockheed Martin by coupling light into the cochlear spiral ganglion of cats with a remote laser and optical fibers...
  58. Is pet ownership associated with childhood asthma?
    John Henderson; Fiscal Year: 2013
    ..A recent review of the role played by cats and dogs in the development of asthma and allergy concluded that, to date, no definitive conclusions can be drawn ..
  59. NCRR RESEARCH TRAINING FOR TUFTS VETERINARY STUDENTS
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2013
    ..Using animal models that include pigs, horses, sheep, goats, cats, dogs, rats and mice, program faculty will provide intensive laboratory training in the research areas of ..
  60. NCRR RESEARCH TRAINING FOR TUFTS VETERINARY STUDENTS
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2011
    ..Using animal models that include pigs, horses, sheep, goats, cats, dogs, rats and mice, program faculty will provide intensive laboratory training in the research areas of ..
  61. CRCNS: Organization of the locomotor CPG in the rodent spinal cord
    Ilya A Rybak; Fiscal Year: 2013
    ..cord injuries, and are in principle capable of restoring locomotion after injury, as demonstrated in rodents and cats. Better understanding of the organization and function of such CPGs will provide essential insights into future ..
  62. Knee CAT Study - Validity of PROMIS Pain Interference and Physical Function CATs
    James J Irrgang; Fiscal Year: 2013
    ..is needed to provide validity evidence for interpretation and use of the pain interference and physical function CATs for patients with a variety of common knee conditions including ACL injuries, meniscus tears or OA...
  63. Antigenic Relationships of SARS and Animal Coronaviruses
    Linda Saif; Fiscal Year: 2006
    ..Genetically similar SARS CoV were isolated from civet cats and raccoon dogs in China and from a recent human SARS case in China suggesting the latter SARS virus reemerged ..
  64. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 2002
    ..Natural infection has been confirmed only in horses, sheep, cattle, birds, and cats; however, primates can be infected experimentally...
  65. DIABETES MELLITUS & ISLET AMYLOID POLYPEPTIDE (IAAP)
    Kenneth Johnson; Fiscal Year: 1991
    ..polypeptide hormone identified as islet amyloid polypeptide (IAPP) was recently purified from islet amyloid (IA) of cats and humans with TYPE 2 diabetes mellitus (DM)...
  66. REMODELING RESEARCH ANIMAL ROOMS
    DONALD MAUL; Fiscal Year: 1990
    ..The research animal facility and the quarantine facility at the Veterinary Teaching Hospital (VTH) currently house cats and/or dogs in projects from the departments of Radiology and Radiation Biology, and Clinical Sciences in the ..
  67. COMPUTER ASSISTED GUIDELINES FOR ADMISSION TESTING
    RANDALL CEBUL; Fiscal Year: 1991
    This is a revised proposal to study the effects of introducing a Computerized Admission Testing System (CATS) into the Emergency Department (ED) of a large urban teaching hospital...
  68. Parasite/Host Interactions and the Neurobiology of Fear
    Robert Sapolsky; Fiscal Year: 2006
    ..The protozoan Toxoplasma gondii reproduces sexually in a two-species life cycle. The parasite reproduces in cats, and is then excreted. Infected feces are eaten by rodents, in which Toxoplasma forms cysts in muscle and the CNS...
  69. Stampidine: A Novel Broad-Spectrum Antiviral Agent
    Taracad Venkatachalam; Fiscal Year: 2003
    ..Pharmacokinetic and toxicity studies of STAMP conducted in mice, rats, cats, and dogs following oral administration of formulated GMP-grade STAMP (25-100 mg/kg/day) as hard gelatin capsules ..
  70. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..contraceptive efficacy studies in rabbits; (iv) single- and/or multiple-dose toxicity studies in mice, rabbits, cats as well as monkey; (v) mucosal, reproductive, and developmental toxicity studies in mice and rabbits; (vi) ..
  71. ANIMAL MODEL OF DRUG-INDUCED SLE
    David Aucoin; Fiscal Year: 1990
    We have reported that greater than 50% of normal healthy cats receiving 150mg daily of propylthiouracil (PTU) develop a lupus- like syndrome within 6 weeks...
  72. INCIDENTAL INFECTIOUS DISEASES AS COFACTORS
    Niels Pedersen; Fiscal Year: 1993
    ..Feline Immunodeficiency Virus (FIV) infection might provide such a model. Specific pathogen free (SPF) cats are available, experimental infections can be created, and various infectious disease exposing environments can be ..
  73. VIRAL-AUTONOMIC INTERACTIONS IN THE TRACHEA
    Cheryl Killingsworth; Fiscal Year: 1991
    ..D. thesis in physiology investigating the autonomic regulation of tracheal smooth muscle in cats exposed to feline viral rhinotracheitis virus...
  74. UNDERSTANDING OVARIAN CONTROL IN RARE BIOMEDICAL MODELS
    KATHARINE PELICAN; Fiscal Year: 2006
    ..will receive state-of-the art training while advancing scholarly knowledge on ovarian cycle control in felids (cats)...
  75. ENDOMEMBRANE TRAFFICKING OF FIV ENVELOPE GLYCOPROTEINS
    D Morre; Fiscal Year: 1993
    ..FIV is a lentivirus that causes lymphadenopathy and increased susceptibility to opportunistic infection in domestic cats. Like its human counterpart, the disease culminates eventually in the death of the infected animals...
  76. RRE LINKED MUCOSAL BARRIER TO LENTIVIRUS INFECTION
    Margaret Barr; Fiscal Year: 2000
    Feline immunodeficiency virus, a lentivirus of cats, provides a natural model for human immunodeficiency virus (HIV) infection and disease...
  77. BIOSYNTHESIS OF OLEAMIDE AND OTHER FATTY ACID AMIDES
    DAVID MERKLER; Fiscal Year: 1999
    ..Oleamide was originally discovered as an agent that accumulates in the cerebral spinal fluid of cats during sleep deprivation...
  78. MARROW TRANSPLANT THERAPY FOR MUCOPOLYSACCHARIDOSIS
    MARY THRALL; Fiscal Year: 1992
    ..Six MPS VI affected-BMT treated cats, two MPS VI affected-BMT treated cats which autologously recovered their own marrow, and 8 MPS VI affected non BMT ..
  79. Characterization of cougar lentiviruses
    Mary Poss; Fiscal Year: 2003
    In the last 2 decades, both humans and domestic cats have become new hosts for lentivirus. Infection results in progressive immunodeficiency and death in both hosts...
  80. A flexible, web-based system for design, support, and delivery of adaptive tests
    ROBERT WIRTH; Fiscal Year: 2009
    ..Although a small number of computerized adaptive tests (CATs) exist for behavioral measurement, they have been designed as "single-use" CATs which were developed to assess a ..