dogs

Summary

Summary: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

Top Publications

  1. pmc On a Cercopithifilaria sp. transmitted by Rhipicephalus sanguineus: a neglected, but widespread filarioid of dogs
    Domenico Otranto
    Dipartimento di Sanità Pubblica e Zootecnia, Universita degli Studi di Bari, Valenzano, BA, Italy
    Parasit Vectors 5:1. 2012
  2. pmc Re-evaluating the burden of rabies in Africa and Asia
    Darryn L Knobel
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, Scotland
    Bull World Health Organ 83:360-8. 2005
  3. pmc Vector-borne helminths of dogs and humans in Europe
    Domenico Otranto
    Dipartimento di Medicina Veterinaria, Universita degli Studi di Bari, Bari, Valenzano, Italy
    Parasit Vectors 6:16. 2013
  4. ncbi Canine parvovirus--a review of epidemiological and diagnostic aspects, with emphasis on type 2c
    Nicola Decaro
    Department of Veterinary Public Health, Faculty of Veterinary Medicine of Bari, Strada per Casamassima Km 3, 70010 Valenzano, Bari, Italy
    Vet Microbiol 155:1-12. 2012
  5. ncbi Genome sequence, comparative analysis and haplotype structure of the domestic dog
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 438:803-19. 2005
  6. ncbi Efficient mapping of mendelian traits in dogs through genome-wide association
    Elinor K Karlsson
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1321-8. 2007
  7. pmc Control of visceral leishmaniasis in latin america-a systematic review
    Gustavo A S Romero
    Nucleo de Medicina Tropical, Faculdade de Medicina, Universidade de Brasilia, Brasilia, Distrito Federal, Brazil
    PLoS Negl Trop Dis 4:e584. 2010
  8. pmc The clathrin adaptor AP-1A mediates basolateral polarity
    Diego Gravotta
    Margaret Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, New York, NY 10065, USA
    Dev Cell 22:811-23. 2012
  9. pmc mtDNA data indicate a single origin for dogs south of Yangtze River, less than 16,300 years ago, from numerous wolves
    Jun feng Pang
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    Mol Biol Evol 26:2849-64. 2009
  10. pmc Prevalence of Dirofilaria immitis, Ehrlichia canis, Borrelia burgdorferi sensu lato, Anaplasma spp. and Leishmania infantum in apparently healthy and CVBD-suspect dogs in Portugal--a national serological study
    Luis Cardoso
    Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Tras os Montes e Alto Douro, Vila Real, Portugal
    Parasit Vectors 5:62. 2012

Detail Information

Publications326 found, 100 shown here

  1. pmc On a Cercopithifilaria sp. transmitted by Rhipicephalus sanguineus: a neglected, but widespread filarioid of dogs
    Domenico Otranto
    Dipartimento di Sanità Pubblica e Zootecnia, Universita degli Studi di Bari, Valenzano, BA, Italy
    Parasit Vectors 5:1. 2012
    ..A large epidemiological survey was conducted by examining skin samples (n = 917) and ticks (n = 890) collected from dogs at different time points in Italy, central Spain and eastern Greece.
  2. pmc Re-evaluating the burden of rabies in Africa and Asia
    Darryn L Knobel
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, Scotland
    Bull World Health Organ 83:360-8. 2005
    ..To quantify the public health and economic burden of endemic canine rabies in Africa and Asia...
  3. pmc Vector-borne helminths of dogs and humans in Europe
    Domenico Otranto
    Dipartimento di Medicina Veterinaria, Universita degli Studi di Bari, Bari, Valenzano, Italy
    Parasit Vectors 6:16. 2013
    ..into non-endemic areas, another example is represented by Thelazia callipaeda eyeworm, an emergent pathogen of dogs, cats and humans in several regions of Europe...
  4. ncbi Canine parvovirus--a review of epidemiological and diagnostic aspects, with emphasis on type 2c
    Nicola Decaro
    Department of Veterinary Public Health, Faculty of Veterinary Medicine of Bari, Strada per Casamassima Km 3, 70010 Valenzano, Bari, Italy
    Vet Microbiol 155:1-12. 2012
    ..In comparison to the original type CPV-2, the antigenic variants display increased pathogenicity in dogs and extended host range, being able to infect and cause disease in cats...
  5. ncbi Genome sequence, comparative analysis and haplotype structure of the domestic dog
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 438:803-19. 2005
    ..The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health...
  6. ncbi Efficient mapping of mendelian traits in dogs through genome-wide association
    Elinor K Karlsson
    Broad Institute of Harvard and Massachusetts Institute of Technology MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1321-8. 2007
    With several hundred genetic diseases and an advantageous genome structure, dogs are ideal for mapping genes that cause disease...
  7. pmc Control of visceral leishmaniasis in latin america-a systematic review
    Gustavo A S Romero
    Nucleo de Medicina Tropical, Faculdade de Medicina, Universidade de Brasilia, Brasilia, Distrito Federal, Brazil
    PLoS Negl Trop Dis 4:e584. 2010
    ....
  8. pmc The clathrin adaptor AP-1A mediates basolateral polarity
    Diego Gravotta
    Margaret Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, New York, NY 10065, USA
    Dev Cell 22:811-23. 2012
    ..The basolateral sorting function of AP-1A reported here establishes AP-1 as a major regulator of epithelial polarity...
  9. pmc mtDNA data indicate a single origin for dogs south of Yangtze River, less than 16,300 years ago, from numerous wolves
    Jun feng Pang
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    Mol Biol Evol 26:2849-64. 2009
    ..We therefore analyzed entire mitochondrial genomes for 169 dogs to obtain maximal phylogenetic resolution and the CR for 1,543 dogs across the Old World for a comprehensive ..
  10. pmc Prevalence of Dirofilaria immitis, Ehrlichia canis, Borrelia burgdorferi sensu lato, Anaplasma spp. and Leishmania infantum in apparently healthy and CVBD-suspect dogs in Portugal--a national serological study
    Luis Cardoso
    Department of Veterinary Sciences, School of Agrarian and Veterinary Sciences, University of Tras os Montes e Alto Douro, Vila Real, Portugal
    Parasit Vectors 5:62. 2012
    Canine vector-borne diseases (CVBDs) are caused by a wide range of pathogens transmitted to dogs by arthropods including ticks and insects...
  11. pmc A molecular network for de novo generation of the apical surface and lumen
    David M Bryant
    Department of Anatomy, University of California, San Francisco, CA 94143 2140, USA
    Nat Cell Biol 12:1035-45. 2010
    ..This Rab11a-directed network directs Cdc42-dependent apical exocytosis during lumen formation, revealing an interaction between the machineries of vesicular transport and polarization...
  12. pmc A single IGF1 allele is a major determinant of small size in dogs
    Nathan B Sutter
    National Human Genome Research Institute, Building 50, Room 5349, 50 South Drive MSC 8000, Bethesda, MD 20892 8000, USA
    Science 316:112-5. 2007
    ..We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size...
  13. pmc Cross-species virus transmission and the emergence of new epidemic diseases
    Colin R Parrish
    Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Microbiol Mol Biol Rev 72:457-70. 2008
    ....
  14. ncbi Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis
    L Solano-Gallego
    Dept Pathology and Infectious Diseases, Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Herts, UK
    Vet Parasitol 165:1-18. 2009
    ..However, although most dogs recover clinically after therapy, complete elimination of the parasite is usually not achieved and infected dogs ..
  15. pmc Dog models of naturally occurring cancer
    JENNIE L ROWELL
    The Ohio State University College of Nursing, 1585 Neil Avenue, Columbus, OH 34210, USA
    Trends Mol Med 17:380-8. 2011
    Studies using dogs provide an ideal solution to the gap in animal models for natural disease and translational medicine...
  16. pmc Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping
    Amaury Vaysse
    Institut de Génétique et Développement de Rennes, CNRS UMR6061, Universite de Rennes 1, Rennes, France
    PLoS Genet 7:e1002316. 2011
    ..Here we perform a comprehensive analysis using multiple test statistics to identify regions under selection in 509 dogs from 46 diverse breeds using a newly developed high-density genotyping array consisting of >170,000 evenly ..
  17. pmc Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication
    Bridgett M VonHoldt
    Department of Ecology and Evolutionary Biology, 621 Charles E Young Drive South, University of California, Los Angeles, California 90095, USA
    Nature 464:898-902. 2010
    ..better, we conducted an extensive genome-wide survey of more than 48,000 single nucleotide polymorphisms in dogs and their wild progenitor, the grey wolf...
  18. pmc The genomic architecture of segmental duplications and associated copy number variants in dogs
    Thomas J Nicholas
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Genome Res 19:491-9. 2009
    ..Our results provide insight into mechanisms of canine genome evolution and generate a valuable resource for future evolutionary and phenotypic studies...
  19. pmc A simple genetic architecture underlies morphological variation in dogs
    Adam R Boyko
    Department of Genetics, Stanford School of Medicine, Stanford, California, United States of America
    PLoS Biol 8:e1000451. 2010
    Domestic dogs exhibit tremendous phenotypic diversity, including a greater variation in body size than any other terrestrial mammal...
  20. ncbi Babesiosis in dogs and cats--expanding parasitological and clinical spectra
    Laia Solano-Gallego
    Department of Pathology and Infectious Diseases, Royal Veterinary College of London, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK
    Vet Parasitol 181:48-60. 2011
    ..Historically, Babesia infection in dogs was identified based on the morphologic appearance of the parasite in the erythrocyte...
  21. ncbi Recent advances in leishmaniosis in pet animals: epidemiology, diagnostics and anti-vectorial prophylaxis
    M Gramiccia
    Vector borne Diseases and International Health, MIPI Department, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Vet Parasitol 181:23-30. 2011
    ..animals are found infected with different Leishmania species but Leishmania infantum is the most widespread being dogs the main reservoir of zoonotic visceral leishmaniosis (ZVL)...
  22. ncbi PNPLA1 mutations cause autosomal recessive congenital ichthyosis in golden retriever dogs and humans
    Anaïs Grall
    Centre National de la Recherche Scientifique, Institut de Génétique et Développement de Rennes, Rennes, France
    Nat Genet 44:140-7. 2012
    ..insertion-deletion (indel) mutation in PNPLA1 that leads to a premature stop codon in all affected golden retriever dogs. We subsequently found one missense and one nonsense mutation in the catalytic domain of human PNPLA1 in six ..
  23. pmc Influenza virus M2 protein mediates ESCRT-independent membrane scission
    Jeremy S Rossman
    Department of Biochemistry, Northwestern University, Evanston, IL 60208, USA
    Cell 142:902-13. 2010
    ..These data suggest that M2 mediates the final steps of budding for influenza viruses, bypassing the need for host ESCRT proteins...
  24. ncbi Canine leishmaniosis in the Old and New Worlds: unveiled similarities and differences
    Filipe Dantas-Torres
    Department of Immunology, Aggeu Magalhães Research Institute, Oswaldo Cruz Foundation, 50670 420 Recife, Pernambuco, Brazil
    Trends Parasitol 28:531-8. 2012
    ..Finally, it calls the attention of veterinary and public health authorities to standardize and improve practices for diagnosing, treating, and preventing the disease...
  25. ncbi Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    R M Chemelli
    Howard Hughes Medical Institute, Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, 75235 9050, USA
    Cell 98:437-51. 1999
    ..knockout mice exhibit a phenotype strikingly similar to human narcolepsy patients, as well as canarc-1 mutant dogs, the only known monogenic model of narcolepsy...
  26. pmc A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity
    David Jackson
    Howard Hughes Medical Institute and Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 105:4381-6. 2008
    ..The increase in pathogenicity was not caused by the overproduction of IFN, suggesting the NS1 protein C terminus may interact with PDZ-binding protein(s) and modulate pathogenicity through alternative mechanisms...
  27. ncbi The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    L Lin
    Center for Narcolepsy, Department of Psychiatry, Stanford University School of Medicine, California 94305 5485, USA
    Cell 98:365-76. 1999
    ..This result identifies hypocretins as major sleep-modulating neurotransmitters and opens novel potential therapeutic approaches for narcoleptic patients...
  28. ncbi Transmission, reservoir hosts and control of zoonotic visceral leishmaniasis
    R J Quinnell
    Institute of Integrative and Comparative Biology, University of Leeds, Leeds LS2 9JT, UK
    Parasitology 136:1915-34. 2009
    Zoonotic visceral leishmaniasis (ZVL) caused by Leishmania infantum is an important disease of humans and dogs. Here we review aspects of the transmission and control of ZVL...
  29. ncbi Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
    Yasuyuki Fujita
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13125 Berlin, Germany
    Nat Cell Biol 4:222-31. 2002
    ..Through dynamic recycling of E-cadherin, Hakai can thus modulate cell adhesion, and could participate in the regulation of epithelial--mesenchymal transitions in development or metastasis...
  30. ncbi Advances in the control of Ctenocephalides felis (cat flea) on cats and dogs
    Michael K Rust
    Department of Entomology, University of California, Riverside, CA 92521 0314, USA
    Trends Parasitol 21:232-6. 2005
    Cat fleas are the most important ectoparasite of cats and dogs worldwide...
  31. pmc LeishVet guidelines for the practical management of canine leishmaniosis
    Laia Solano-Gallego
    Department of Pathology and Infectious Diseases, Royal Veterinary College of London, London, UK
    Parasit Vectors 4:86. 2011
    ....
  32. ncbi PCR diagnosis and characterization of Leishmania in local and imported clinical samples
    Gabriele Schonian
    Institute of Microbiology and Hygiene, Humboldt University, Charite, Berlin, Germany
    Diagn Microbiol Infect Dis 47:349-58. 2003
    ..113 cases (69.7%) were positive by PCR and species identification was possible in 110 samples. Leishmania DNA was also amplified and identified at the species level from archived non-stained and Giemsa stained microscope slides...
  33. pmc In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
    Yasushi Itoh
    Department of Pathology, Shiga University of Medical Science, Ohtsu, Shiga 520 2192, Japan
    Nature 460:1021-5. 2009
    ..Finally, we show that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic...
  34. ncbi Emerging arthropod-borne diseases of companion animals in Europe
    Frederic Beugnet
    Meria Animal Health, 69007, Lyon, France
    Vet Parasitol 163:298-305. 2009
    ..Here, after consideration of the main reasons for changes in tick vector ecology, an overview of each "emerging" vector-borne diseases of pets is presented...
  35. pmc The fecal microbiome in dogs with acute diarrhea and idiopathic inflammatory bowel disease
    Jan S Suchodolski
    Gastrointestinal Laboratory, Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX, USA
    PLoS ONE 7:e51907. 2012
    ..is mounting evidence that microbes play an important role in the pathogenesis of acute and chronic enteropathies of dogs, including idiopathic inflammatory bowel disease (IBD)...
  36. pmc Association between nasal shedding and fever that influenza A (H3N2) induces in dogs
    DaeSub Song
    Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejon 305 806, Korea
    Virol J 8:1. 2011
    ..This study was focused on viral excretion and fever in order to elucidate the epidemiological associations which might be helpful to control the disease transmissions in CIV outbreak in dogs.
  37. ncbi Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model
    Guilherme V Silva
    Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Tex 77030, USA
    Circulation 111:150-6. 2005
    ..Bone marrow-derived stem cells are under investigation as a treatment for ischemic heart disease. Mesenchymal stem cells (MSCs) have been used preferentially in the acute ischemia model; data in the chronic ischemia model are lacking...
  38. ncbi Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions
    Hector Peinado
    Instituto de Investigaciones Biomédicas Alberto Sols CSIC UAM and Departamento de Bioquímica UAM, Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 278:21113-23. 2003
    ..These data support that MAPK and phosphatidylinositol 3-kinase signaling pathways are implicated in TGFbeta1-mediated induction of Snail promoter, probably through Ras activation and its downstream effectors...
  39. ncbi Translation of new cancer treatments from pet dogs to humans
    Melissa Paoloni
    Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Room 2144, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 8:147-56. 2008
    Naturally occurring cancers in pet dogs and humans share many features, including histological appearance, tumour genetics, molecular targets, biological behaviour and response to conventional therapies...
  40. pmc Molecular characterization of insulin-mediated suppression of hepatic glucose production in vivo
    Christopher J Ramnanan
    Department of Molecular Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 59:1302-11. 2010
    ..We determined, for the first time, the time course and relevance (to metabolic flux) of these molecular events during physiological hyperinsulinemia in vivo in a large animal model...
  41. pmc Phylodynamics and human-mediated dispersal of a zoonotic virus
    Chiraz Talbi
    Institut Pasteur, Unit Lyssavirus Dynamics and Host Adaptation, WHO Collaborating Centre for Reference and Research on Rabies, Paris, France
    PLoS Pathog 6:e1001166. 2010
    ....
  42. ncbi The role of cytokines in osteoarthritis pathophysiology
    Julio C Fernandes
    Osteoarthritis Research Unit, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
    Biorheology 39:237-46. 2002
    ..Future directions in the research and treatment of osteoarthritis (OA) will be based on the emerging picture of pathophysiological events that modulate the initiation and progression of OA...
  43. pmc Altered receptor specificity and cell tropism of D222G hemagglutinin mutants isolated from fatal cases of pandemic A(H1N1) 2009 influenza virus
    Yan Liu
    The Glycosciences Laboratory, Department of Medicine, Imperial College London, UK
    J Virol 84:12069-74. 2010
    ..These features of 222G mutants may contribute to exacerbation of disease...
  44. ncbi Canine leishmaniosis - new concepts and insights on an expanding zoonosis: part one
    Gad Baneth
    School of Veterinary Medicine, Hebrew University, PO Box 12, Rehovot, Israel
    Trends Parasitol 24:324-30. 2008
    ..In addition, infection spreads rapidly among dogs in the presence of optimal conditions for transmission...
  45. ncbi Genetic evidence for an East Asian origin of domestic dogs
    Peter Savolainen
    Department of Biotechnology, Royal Institute of Technology KTH, 10691 Stockholm, Sweden
    Science 298:1610-3. 2002
    ..To address these questions, we examined the mitochondrial DNA (mtDNA) sequence variation among 654 domestic dogs representing all major dog populations worldwide...
  46. ncbi A prospective study on the clinical features of chronic canine atopic dermatitis and its diagnosis
    Claude Favrot
    Clinical for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    Vet Dermatol 21:23-31. 2010
    ..Sets of criteria have been proposed but are mainly used to include dogs in clinical studies...
  47. pmc Tracking footprints of artificial selection in the dog genome
    Joshua M Akey
    Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:1160-5. 2010
    ..Here, we describe a genome-wide scan for selection in 275 dogs from 10 phenotypically diverse breeds that were genotyped for over 21,000 autosomal SNPs...
  48. pmc 16S rRNA gene pyrosequencing reveals bacterial dysbiosis in the duodenum of dogs with idiopathic inflammatory bowel disease
    Jan S Suchodolski
    Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, Texas, United States of America
    PLoS ONE 7:e39333. 2012
    ..The objective of this study was to evaluate mucosa-adherent microbiota in the duodenum of dogs with spontaneous idiopathic IBD using 16 S rRNA gene pyrosequencing.
  49. pmc Rethinking dog domestication by integrating genetics, archeology, and biogeography
    Greger Larson
    Durham Evolution and Ancient DNA, Department of Archaeology, University of Durham, Durham DH1 3LE, United Kingdom
    Proc Natl Acad Sci U S A 109:8878-83. 2012
    ..of modern genetic data to elucidate the origins of dog domestication, we analyzed 49,024 autosomal SNPs in 1,375 dogs (representing 35 breeds) and 19 wolves...
  50. pmc Differential genetic regulation of canine hip dysplasia and osteoarthritis
    Zhengkui Zhou
    College of Animal Science and Technology, Northwest A and F University, Yangling, China
    PLoS ONE 5:e13219. 2010
    Canine hip dysplasia (HD) is a common polygenic trait characterized by hip malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human hip which also leads to OA.
  51. pmc Use of a LiESP/QA-21 vaccine (CaniLeish) stimulates an appropriate Th1-dominated cell-mediated immune response in dogs
    Javier Moreno
    WHO Collaborating Centre for Leishmaniasis, Centro Nacional de Microbiologia, Instituto de Carlos III, Madrid, Spain
    PLoS Negl Trop Dis 6:e1683. 2012
    Canine leishmaniasis is an important zoonotic disease of dogs. The clinical outcome of infection is variable, with the efficiency of the immune response being the key determining factor...
  52. pmc The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats
    Dorothee Stanneck
    Bayer Animal Health GmbH, Leverkusen, Germany
    Parasit Vectors 5:73. 2012
    The control of tick and flea burdens in dogs and cats has become essential to the control of important and emerging vector borne diseases, some of which are zoonoses...
  53. ncbi Massive parallel 16S rRNA gene pyrosequencing reveals highly diverse fecal bacterial and fungal communities in healthy dogs and cats
    Stefanie Handl
    Department for Farm Animals and Veterinary Public Health, Institute of Animal Nutrition, University of Veterinary Medicine Vienna, Vienna, Austria
    FEMS Microbiol Ecol 76:301-10. 2011
    This study evaluated the fecal microbiota of 12 healthy pet dogs and 12 pet cats using bacterial and fungal tag-encoded FLX-Titanium amplicon pyrosequencing...
  54. ncbi Effect of a multi-species synbiotic formulation on fecal bacterial microbiota of healthy cats and dogs as evaluated by pyrosequencing
    Jose F Garcia-Mazcorro
    Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A and M University, College Station, TX, USA
    FEMS Microbiol Ecol 78:542-54. 2011
    The effect of a multi-species synbiotic on the fecal microbiota of healthy cats (n = 12) and dogs (n = 12) was evaluated...
  55. ncbi Evidence for evolution of canine parvovirus type 2 in Italy
    C Buonavoglia
    Department of Animal Health and Well Being, Faculty of Veterinary Medicine of Bari, s p per Casamassima km 3, 70010 Valenzano, Bari, Italy
    J Gen Virol 82:3021-5. 2001
    Two isolates of canine parvovirus (CPV) were obtained from dogs affected with severe haemorrhagic diarrhoea...
  56. ncbi Leader of the pack: gene mapping in dogs and other model organisms
    Elinor K Karlsson
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge Center, 02142, USA
    Nat Rev Genet 9:713-25. 2008
    ..Here, we review the different trait-mapping strategies, some key biological findings emerging from recent studies and the implications for human health. We also discuss the development of similar resources for other vertebrate organisms...
  57. ncbi Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly
    T S Jou
    Department of Anatomy, Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA
    Nat Cell Biol 3:831-8. 2001
    ..These findings implicate Rac1-mediated laminin assembly in apical pole orientation. By linking apical orientation to generation of the basement membrane, epithelial cells ensure the coordination of polarity with tissue architecture...
  58. pmc Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach
    Milcah C Scott
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 5545, USA
    Bone 49:356-67. 2011
    ..The occurrence of spontaneous osteosarcoma is largely confined to humans and dogs. While the clinical features are remarkably similar in both species, the organization of dogs into defined breeds ..
  59. pmc Virulence-associated substitution D222G in the hemagglutinin of 2009 pandemic influenza A(H1N1) virus affects receptor binding
    Salin Chutinimitkul
    Department of Virology, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands
    J Virol 84:11802-13. 2010
    ..Altered receptor specificity of the virus with D222G thus affected interaction with cells of the human lower respiratory tract, possibly explaining the observed association with enhanced disease in humans...
  60. pmc Aligning multiple genomic sequences with the threaded blockset aligner
    Mathieu Blanchette
    Howard Hughes Medical Institute, University of California at Santa Cruz, Santa Cruz, California 95064, USA
    Genome Res 14:708-15. 2004
    ..We describe our use of MULTIZ to produce the whole-genome multiple alignments at the Santa Cruz Genome Browser...
  61. ncbi Heartworm disease in animals and humans
    John W McCall
    Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Adv Parasitol 66:193-285. 2008
    Heartworm disease due to Dirofilaria immitis continues to cause severe disease and even death in dogs and other animals in many parts of the world, even though safe, highly effective and convenient preventatives have been available for ..
  62. ncbi Lutzomyia longipalpis and the eco-epidemiology of American visceral leishmaniasis, with particular reference to Brazil: a review
    Ralph Lainson
    Departamento de Parasitologia, Instituto Evandro Chagas, Belem, PA, Brazil
    Mem Inst Oswaldo Cruz 100:811-27. 2005
    ..Although effective control measures in foci of the disease will diminish the number of canine and human infections, the presence of such an enzootic in a variety of native animals will render the total eradication of AVL unlikely...
  63. pmc Collective migration of an epithelial monolayer in response to a model wound
    M Poujade
    Laboratoire Physico Chimie Curie Unité Mixte de Recherche 168, Institut Curie, Centre National de Recherche Scientifique, Universite Pierre et Marie Curie, F 75248 Paris, France
    Proc Natl Acad Sci U S A 104:15988-93. 2007
    ..Experiments performed with autocrine cells constitutively expressing hepatocyte growth factor (HGF) or in the presence of exogenous HGF show a higher average velocity of the border and no leader...
  64. pmc Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa
    William A Beltran
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:2132-7. 2012
    ..Efficacy of gene therapy in these large animal models of X-linked retinitis pigmentosa provides a path for translation to human treatment...
  65. ncbi Current evidence of skin barrier dysfunction in human and canine atopic dermatitis
    Rosanna Marsella
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
    Vet Dermatol 22:239-48. 2011
    ..The purpose of this comparative review is to present the current evidence of barrier dysfunction in both human and canine AD...
  66. pmc Prevalence and factors associated with Leishmania infantum infection of dogs from an urban area of Brazil as identified by molecular methods
    Wendel Coura-Vital
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS Negl Trop Dis 5:e1291. 2011
    ..The aim of this study was to determine the prevalence of canine visceral leishmaniasis in an urban endemic area in Brazil and the factors associated with Leishmania infantum infection among seronegative and PCR-positive dogs.
  67. ncbi Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms
    G Rubinsky-Elefant
    Laboratory of Seroepidemiology and Immunobiology, Institute of Tropical Medicine of São Paulo, Avenida Dr Eneas de Carvalho Aguiar 470, 05403 000, Sao Paulo, SP, Brazil
    Ann Trop Med Parasitol 104:3-23. 2010
    ..The causal agents are the nematode parasites Toxocara canis and T. cati, whose definitive hosts are dogs and cats, respectively...
  68. pmc A supramolecular assembly formed by influenza A virus genomic RNA segments
    Emilie Fournier
    Architecture et Reactivite de l ARN, Universite de Strasbourg, CNRS, IBMC, 15 rue Rene Descartes, 67084 Strasbourg, France
    Nucleic Acids Res 40:2197-209. 2012
    ..Collectively, our findings support a model in which the eight genomic RNA segments are selected and packaged as an organized supramolecular complex held together by direct base pairing of the packaging signals...
  69. ncbi Selective imitation in domestic dogs
    Friederike Range
    Department for Neurobiology and Cognition Research, University of Vienna, Vienna 1091, Austria
    Curr Biol 17:868-72. 2007
    ..In the first trial after observation, dogs imitated the nonpreferred action only in the second group...
  70. ncbi The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    G Joberty
    Markey Center for Cell Signaling, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908 0577, USA
    Nat Cell Biol 2:531-9. 2000
    ..This assembly is implicated in the formation of normal tight junctions at epithelial cell-cell contacts. Thus, Par6 is a key adaptor that links Cdc42 and atypical PKCs to Par3...
  71. pmc Global gene expression profiles of canine macrophages and canine mammary cancer cells grown as a co-culture in vitro
    Magdalena Król
    Department of Physiological Sciences, Warsaw University of Life Sciences WULS, Warsaw, Poland
    BMC Vet Res 8:16. 2012
    ..The results were confirmed using real-time qPCR and confocal microscopy. Moreover, their ability for migration and invasion has been assessed...
  72. pmc The origin and phylogeography of dog rabies virus
    Herve Bourhy
    Institut Pasteur, UPRE Lyssavirus Dynamics and Host Adaptation, World Health Organization Collaborating Centre for Reference and Research on Rabies, Institut Pasteur, 75724 Paris Cedex 15, France
    J Gen Virol 89:2673-81. 2008
    ..Overall, our study reveals that the stochastic processes of genetic drift and population subdivision are the most important factors shaping the global phylogeography of canid RABV...
  73. pmc Variations in the hemagglutinin of the 2009 H1N1 pandemic virus: potential for strains with altered virulence phenotype?
    Jianqiang Ye
    Virginia Maryland Regional College of Veterinary Medicine, College Park, Maryland, United States of America
    PLoS Pathog 6:e1001145. 2010
    ..The rapid selection of ma-Ca/04 in mice suggests that a virus containing this constellation of amino acids might have already been present in Ca/04, likely as minor quasispecies...
  74. ncbi PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts
    S O Marx
    Center for Molecular Cardiology, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Cell 101:365-76. 2000
    ..6, PKA, the protein phosphatases PP1 and PP2A, and an anchoring protein, mAKAP. In failing human hearts, RyR2 is PKA hyperphosphorylated, resulting in defective channel function due to increased sensitivity to Ca2+-induced activation...
  75. ncbi Prevention and control of cystic echinococcosis
    Philip S Craig
    Cestode Zoonoses Research Group, School of Environment and Life Sciences, University of Salford, Salford, UK
    Lancet Infect Dis 7:385-94. 2007
    ..Incorporation of these new measures could increase the efficiency of hydatid control programmes, potentially reducing the time required to achieve effective prevention of disease transmission to as little as 5-10 years...
  76. ncbi Word learning in a domestic dog: evidence for "fast mapping"
    Juliane Kaminski
    Department of Developmental and Comparative Psychology, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Science 304:1682-3. 2004
    ..Fast mapping thus appears to be mediated by general learning and memory mechanisms also found in other animals and not by a language acquisition device that is special to humans...
  77. pmc Four loci explain 83% of size variation in the horse
    Shokouh Makvandi-Nejad
    Department of Clinical Sciences, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 7:e39929. 2012
    ..Our results in the horse, complemented by the prior work in cattle and dog, serve to pinpoint those very few genes that have played major roles in the rapid evolution of size during domestication...
  78. pmc The prevalence of canine Leishmania infantum infection in western China detected by PCR and serological tests
    Jun yun Wang
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People s Republic of China
    Parasit Vectors 4:69. 2011
    ..In the present study we report for the first time prevalence of Leishmania infection in dogs living in Jiuzhaigou County (Sichuan Provence, China), which is not only an important endemic area of CanL but also ..
  79. pmc Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells
    M Furuse
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 153:263-72. 2001
    ....
  80. pmc CCDC39 is required for assembly of inner dynein arms and the dynein regulatory complex and for normal ciliary motility in humans and dogs
    Anne Christine Merveille
    Unit of Animal Genomics, Groupe Interdisciplinaire de Genomique Appliquee Recherche GIGA R and Faculty of Veterinary Medicine, University of Liège B34, Liege, Belgium
    Nat Genet 43:72-8. 2011
    ..Functional analyses indicated that CCDC39 localizes to ciliary axonemes and is essential for assembly of inner dynein arms and the dynein regulatory complex...
  81. ncbi Role of pet dogs and cats in the transmission of helminthic zoonoses in Europe, with a focus on echinococcosis and toxocarosis
    Peter Deplazes
    Institute of Parasitology, Vetsuisse Faculty, University of Zurich, Switzerland
    Vet Parasitol 182:41-53. 2011
    ..However, pet dogs and cats can play an important role in the transmission of helminthic zoonotic agents such as the tapeworms ..
  82. pmc Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins
    Yi Hao
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Curr Biol 20:1809-18. 2010
    ..Defects in signaling through Cdc42 and atypical protein kinase C (aPKC) also cause spindle misorientation. When epithelial cysts are grown in 3D cultures, misorientation creates multiple lumens...
  83. pmc Thelazia callipaeda: infection in dogs: a new parasite for Spain
    Guadalupe Miró
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, de Madrid, Spain
    Parasit Vectors 4:148. 2011
    ..Italy, France, Germany and Switzerland). In June 2010, the first case of canine thelaziosis was observed in central western Spain (La Vera region, Cáceres) and subsequent epidemiological investigation is reported in the present study...
  84. ncbi Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies
    R L Winslow
    Department of Biomedical Engineering, Center for Computational Medicine and Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Circ Res 84:571-86. 1999
    ..Model analyses also suggest that altered expression of Ca2+ handling proteins plays a significant role in prolongation of action potential duration in failing canine myocytes...
  85. ncbi Attachment behavior of adult dogs (Canis familiaris) living at rescue centers: forming new bonds
    M Gacsi
    Comparative Ethology Research Group, Hungarian Academy of Sciences, Budapest
    J Comp Psychol 115:423-31. 2001
    In this study, 60 shelter dogs (Canis familiaris) were observed in the modified version of the Strange Situation Test, which has proved to be a useful method for studying dogs' attachment behavior toward humans (J. Topál, A. Miklósi, V...
  86. pmc Possible involvement of phosphorylation of occludin in tight junction formation
    A Sakakibara
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Cell Biol 137:1393-401. 1997
    ..These findings suggest that the phosphorylation of occludin is a key step in tight junction assembly...
  87. pmc Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts
    Yuma Iwai
    Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima, Japan
    PLoS ONE 6:e19825. 2011
    ..Our present results indicate that marchantins are candidate anti-influenza drugs and demonstrate the utility of the PA endonuclease assay in the screening of phytochemicals for anti-influenza characteristics...
  88. ncbi Neurotoxocarosis
    Josef Finsterer
    Neurological Department, Krankenanstalt Rudolfstiftung
    Rev Inst Med Trop Sao Paulo 49:279-87. 2007
    ..If detected and treated early, the prognosis of neurological manifestations of toxocarosis is favourable...
  89. ncbi Morphological and molecular data on the dermal microfilariae of a species of Cercopithifilaria from a dog in Sicily
    Domenico Otranto
    Dipartimento di Sanità Pubblica e Zootecnia, Universita degli Studi di Bari, 70010 Valenzano, Bari, Italy
    Vet Parasitol 182:221-9. 2011
    ..and genetically and differentiated from those of all the other blood microfilariae commonly found in dogs. In particular, the microfilariae were short (mean length of 186...
  90. ncbi Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    Lazaros A Nikolaidis
    Department of Medicine, Allegheny General Hospital, Pittsburgh, PA 15212, USA
    Circulation 110:955-61. 2004
    ..impact of recombinant GLP-1 (rGLP-1) on LV and systemic hemodynamics and myocardial substrate uptake in conscious dogs with advanced dilated cardiomyopathy (DCM) as a mechanism for overcoming myocardial insulin resistance and ..
  91. pmc A single-amino-acid substitution in the HA protein changes the replication and pathogenicity of the 2009 pandemic A (H1N1) influenza viruses in vitro and in vivo
    Lili Xu
    Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences CAMS and Comparative Medicine Center, Peking Union Medical Collage PUMC, Beijing 100021, China
    Virol J 7:325. 2010
    ....
  92. ncbi Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs
    Bok Ki Kang
    Department of Polymer Science and Engineering, Chonbuk National University, Duckjin Dong, Jeonju 561 756, South Korea
    Int J Pharm 274:65-73. 2004
    ..was compared with the conventional tablet (Zocor) by administering the prefilled hard capsules to fasted beagle dogs. The absorption of simvastatin acid from SMEDDS form resulted in about 1...
  93. ncbi Decrease of the incidence of human and canine visceral leishmaniasis after dog vaccination with Leishmune in Brazilian endemic areas
    Clarisa B Palatnik-de-Sousa
    Department of General Microbiology, Institute of Microbiology Prof Paulo de Góes, Federal University of Rio de Janeiro UFRJ, Rio de Janeiro, RJ, Brazil
    Vaccine 27:3505-12. 2009
    ..licensed against canine visceral leishmaniasis (CVL), has been used in Brazil since 2004, where seropositive dogs are sacrificed in order to control human visceral leishmaniasis (VL)...
  94. pmc Dynamics of biologically active subpopulations of influenza virus: plaque-forming, noninfectious cell-killing, and defective interfering particles
    Philip I Marcus
    Department of Molecular and Cell Biology, Center of Excellence for Vaccine Research, University of Connecticut, Storrs, 06269, USA
    J Virol 83:8122-30. 2009
    ..DIP have been implicated in the virulence of influenza virus, but the role of niCKP is yet unknown...
  95. ncbi Canine leishmaniasis
    Jorge Alvar
    WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    Adv Parasitol 57:1-88. 2004
    ..L. chagasi, in America) and is transmitted by the bite of phlebotomine sand flies. Infected dogs constitute the main domestic reservoir of the parasite and play a key role in transmission to humans, in which the ..
  96. ncbi Chemotherapy of canine leishmaniosis
    Gad Baneth
    School of Veterinary Medicine, Hebrew University, P O Box 12, 76100, Rehovot, Israel
    Vet Parasitol 106:315-24. 2002
    Visceral leishmaniosis is a widespread and potentially fatal disease of dogs and humans common in the Mediterranean region, the Middle East, and South America...
  97. pmc Epidemiological investigations of human rabies in China
    Miao Song
    State Key Laboratory for Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, PR China
    BMC Infect Dis 9:210. 2009
    ..Moreover, the status of rabies infection and vaccination in dogs, and prophylaxis of humans after rabies exposure were analyzed.
  98. ncbi Isotype patterns of immunoglobulins: hallmarks for clinical status and tissue parasite density in Brazilian dogs naturally infected by Leishmania (Leishmania) chagasi
    Alexandre B Reis
    Laboratorio de Imunologia Celular e Molecular, Centro de Pesquisas Rene Rachou, Fundacao Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
    Vet Immunol Immunopathol 112:102-16. 2006
    ..the background on this issue, herein, we have evaluated, in Leishmania (Leishmania) chagasi naturally infected dogs, the relationship between tissue parasitism (skin, bone marrow, spleen, liver and lymph node), the CVL clinical ..
  99. pmc Integrin-dependent actomyosin contraction regulates epithelial cell scattering
    Johan de Rooij
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 171:153-64. 2005
    ..We conclude that integrin-dependent actomyosin traction force mediates the disruption of cell-cell adhesion during epithelial cell scattering...
  100. pmc Patterns of positive selection in six Mammalian genomes
    Carolin Kosiol
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 4:e1000144. 2008
    ..This study provides additional evidence for widespread positive selection in mammalian evolution and new genome-wide insights into the functional implications of positive selection...
  101. ncbi A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis
    Ji Young Min
    Institute for Cellular and Molecular Biology, Section of Molecular Genetics and Microbiology, room 2 122, 2500 Speedway, University of Texas at Austin, Austin, TX 78712, USA
    Virology 363:236-43. 2007
    ..This interaction would occur in the nucleus, whereas PKR would bind to NS1A proteins in the cytoplasm prior to their import into the nucleus...

Research Grants77

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..Serial biopsy samples will be taken from the ischemic and nonischemic areas during I/R in dogs. We will study the time course of FAK dephosphorylation and activation of downstream signaling pathways ERK, JNK, ..
  3. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
    ..g., use of pigs to study obesity and diabetes and dogs for cardiopulmonary diseases...
  4. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer
    Paul J Shami; Fiscal Year: 2012
    ..LS/MS/MS assay for measuring JS-K in biologic fluids;and 2) complete acute IV toxicology studies of JS-K in dogs and 28-day subchronic IV toxicology studies of JS-K in rats and dogs...
  5. Inhibition of IkK to treat lethal Graft-vs.-Host Disease
    Patrick Flood; Fiscal Year: 2009
    ..Finally, studies are proposed to investigate the pharmacokinetics and pharmacodynamics of the compound in dogs after transplantation...
  6. Systemic Inflammation and Central Nervous System Dysfunction
    Laura L Dugan; Fiscal Year: 2013
    ..Loss of these neurons is observed in rodents, dogs, and primates, and has been proposed to underlie cognitive deficits across cognitive domains...
  7. N-methanocarbathymidine (N-MCT) for the Treatment of Herpes and Pox Virus Infecti
    Aquilur Rahman; Fiscal Year: 2013
    ..and pox viruses and drug-resistant variants in vivo at doses that are non-cytotoxic in mice, rats, guinea pigs and dogs, even at doses 1000-fold higher than the therapeutic dose...
  8. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2013
    ..resorption, (iii) test tolerability of topical formulations for delivery of GM-0111 into the sulcus in dose-ranging studie in beagle dogs, and (iv) conduct a pivotal study in beagle dogs to test the efficacy of the selected formulation.
  9. SARS-CoV Pathogenic Mechanisms in Senescent Mice
    Ralph S Baric; Fiscal Year: 2012
    ..SARS-CoV) is a zoonotic pathogen that likely emerged from bats, was amplified in civet cats and raccoon dogs and then transmitted to humans causing severe acute respiratory disease, pneumonia, and high mortality rates in the ..
  10. Retroviral Vector-mediated Liver Gene Therapy for MPS I
    Katherine P Ponder; Fiscal Year: 2013
    ..with an intact long-terminal repeat (LTR) expressing canine IDUA had a truly remarkable effect in both mice and dogs with MPS I, with elimination or reduction in all major clinical manifestations...
  11. Iowa Phase II Clinical Trials of Novel Therapies for Lung Diseases (U01
    Lakshmi Durairaj; Fiscal Year: 2012
    ..In a 2 week, 2 animal species study done under good laboratory practices, beagle dogs and rats tolerated inhaled xylitol well...
  12. Proteomic signatures of an early life asthma-protective exposure
    Serrine S Lau; Fiscal Year: 2010
    ..g., indoor dogs) is associated with strong protection against asthma and asthma-related phenotypes (allergy, eczema) later in life...
  13. Adjunctive Use of Apyrase to Fibrinolytic Therapy
    Ridong Chen; Fiscal Year: 2013
    ..With the Phase I award, we demonstrated that in the r-tPA induced fibrinolysis model in dogs, treatment of APT102 completely prevented re-occlusion, maintained normal blood flow, and profoundly reduced ..
  14. Novel Small Molecule Therapeutics to Treat Obesity
    SUSAN MEDGHALCHI; Fiscal Year: 2010
    ..measurements to select a lead compound [4] perform a 5-day rat TK study, [5] undergo cardiac testing in conscious dogs, and [6] conclude a formal 28-day preclinical GLP rat toxicity study...
  15. Disruption of Autonomic Pathways in Left Atrium by Inhibition of G Proteins
    Alan H Kadish; Fiscal Year: 2010
    ..to study the effects of the peptide(s) on ion-channels that mediate autonomic effects, and in b) intact dogs, with localized injection into the PLA in order to inhibit vagally or adrenergically-mediated AF...
  16. Mechanisms regulating SR Ca2+ ATPase in the Atria
    Muthu Periasamy; Fiscal Year: 2012
    ..In addition, we found that SLN levels are significantly altered in diseased atria (heart failure and arrhythmia) of dogs and human, suggesting that an alteration in SLN /SERCA ratio could contribute to altered Ca2+ transport in failing ..
  17. Bifunctional Redox Catalyst &Organic Nitrate for Limb Reperfusion
    ANDREW LURIE SALZMAN; Fiscal Year: 2013
    ..IV dose range-finding and 2 week repeat-dose toxicology studies in rats and dogs, with associated toxicokinetic determinations.
  18. Abnormality in Gene Expression of Key Mediators of Vitamin A Action in COPD
    Salil K Das; Fiscal Year: 2010
    ..RA is known to be effective in promoting alveolization in papain-induced emphysema in dogs and elastase-induced emphysema in adult rats...
  19. Gluconeogenesis and Glycogenolysis - Role and Regulation
    Alan D Cherrington; Fiscal Year: 2013
    ..Studie will be carried out in normal and diet induced insulin resistant conscious dogs. Three weeks before study catheters will be inserted under general anesthesia into the femoral artery, the hepatic ..
  20. Disruption of Autonomic Pathways in the Left Atrium by Inhibition of G-proteins
    Rishi Arora; Fiscal Year: 2013
    ..of minigene into the PLA will be performed in order to inhibit vagally or adrenergically-mediated AF in normal dogs. In Aim 2, we propose to use these minigenes in a canine model of chronic AF;minigenes under the control of a long-..
  21. Rabies virus maintenance in bat populations
    APRIL DAWN DAVIS; Fiscal Year: 2013
    ..In the United States, large scale rabies outbreaks have been reported in other vector species such as dogs, skunks, raccoons, and foxes. However, to date, rabies outbreaks have not occurred in bat populations...
  22. Gene Therapy of Mucopolysaccharidosis VII
    Mark E Haskins; Fiscal Year: 2012
    ..repeat (LTR) expressing canine GUSB resulted in efficient transduction of liver cells in both mice and dogs with MPS VII...
  23. Physiology and Biophysics of Cardiac Slo2.1 Channels
    Alexey V Zaitsev; Fiscal Year: 2012
    ..IKATP in these phenomena will also be investigated in the whole heart (Aim 2) and in isolated myocytes (Aim 3) of dogs. Together these studies will define 1) the molecular basis of KNa channel activation, 2) the role of these channels ..
  24. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    David Stump; Fiscal Year: 2013
    ..We will perform MRI on six groups of dogs which simulate surgical embolic events...
  25. Brain Vascular Studies in Cardiac and Orthopedic Surgery
    William Brown; Fiscal Year: 2009
    ..We will perform MRI on six groups of dogs which simulate surgical embolic events...
  26. The Evolutionary and Biological Bases of Host Switching in Viruses
    Colin R Parrish; Fiscal Year: 2013
    ..and extend our work on two well characterized animal viruses that have successfully jumped species barriers to dogs in the recent past and which represent powerful and experimentally tractable models for human emerging viruses;the ..
  27. K777 for treatment of Chagas Disease: IND-enabling Studies and IND Submission
    Robert Don; Fiscal Year: 2012
    ..K777 has since been shown to be efficacious in models of acute and chronic Chagas disease in both mice and dogs. K777 is non-mutagenic, has an acceptable PK profile, and has been shown to be well tolerated in animal safety ..
  28. Virus Clearance from the Central Nervous System
    Rodney E Willoughby; Fiscal Year: 2013
    ..TriGAS therapy will be optimized in mice, validated in dogs, and preclinically correlated with biomarkers of protective immunity in TriGAS-infected human brain tissues in ..
  29. Dual AAV Vectors for Duchenne Muscular Dystrophy Therapy
    Dongsheng Duan; Fiscal Year: 2012
    ..We have now overcome this hurdle and achieved systemic single AAV transduction in wild type newborn dogs. This is the first demonstration of a whole body gene transfer in a large animal model...
  30. Towards a Model of Fanconi Anemia
    BEVERLY JO TOROK STORB; Fiscal Year: 2010
    ..we will take several parallel paths to exploit this approach to derive the tools to generate genetically modified dogs, focusing on the future generation of a Fanconi anemia dog as a test of principle...
  31. MYOCARDIAL PERFUSION IN THE HYPERTROPHIED HEART
    ROBERT JAMES BACHE; Fiscal Year: 2010
    ..Pacing-induced tachycardia will be used to produce CHF in dogs;animals will be chronically instrumented for measurement of left ventricular (LV) function and MVO2...
  32. IL12 Gene Therapy For Enhancing Therapeutic Efficacy of Bleomycin Against Oral Tu
    Shulin Li; Fiscal Year: 2013
    ..Our preliminary study in two dogs also suggests that IL12 gene therapy may prevent tumor redevelopment when co-administered with bleomycin via ..
  33. Novel Adeno-Associated Viral Therapy for X-linked Retinitis Pigmentosa
    James M Wilson; Fiscal Year: 2010
    ..promoter and RPGR transgene will be put through biodistribution and safety/toxicology studies in mice and in dogs to complete the package of data needed for filing an IND...
  34. Developing a Paramyxovirus-based H5N1 Vaccine
    Biao He; Fiscal Year: 2012
    ..Parainfluenza virus 5 (PIV5), a paramyxovirus, causes kennel cough in dogs, but is not known to cause any illness in humans...
  35. Excitotoxicity in Circulatory Arrest ? Brain Injury
    WILLIAM ANTHONY BAUMGARTNER; Fiscal Year: 2012
    ..In our canine model, which replicates clinical experience during cardiac surgical procedures, dogs subjected to two hours of HCA at 180C sustain a consistent neurologic deficit and histological pattern of selective ..
  36. A Novel Approach for Mycobacterium Tuberculosis Vaccine Development
    Biao He; Fiscal Year: 2013
    ..First, kennel cough vaccines containing live PIV5 have been used in dogs over 30 years. Humans are likely exposed to this virus due to close contact to dogs...
  37. Therapeutic Development for Amyotrophic Lateral Sclerosis in a Canine Model
    JOAN RIPLEY COATES; Fiscal Year: 2013
    ..Specific Aims: 1) Evaluate the safety and pharmacokinetics of intrathecal delivery of a SOD1 ASO in normal dogs to develop an optimized protocol for therapy in DM...
  38. Mechanisms of Brain Injury after Intraventricular Hemorrhage
    Guohua Xi; Fiscal Year: 2013
    ..cells reaches its peak concentration by the second day following injection of blood into the cerebrospinal fluid of dogs. Hemoglobin release, from lysis of erythrocytes in human intracranial hemorrhage, increases during the first few ..
  39. MECHANOTRANSDUCTION IN INTESTINAL SMOOTH MUSCLE CELLS
    Gianrico Farrugia; Fiscal Year: 2013
    ..Nav1.5 is selectively expressed. It generates a Na+ current in the intestinal tract of humans, dogs and rats but not in several other species such as guinea pig and mouse. Mutations in Nav1.5 cause disease...
  40. Pyruvate: Powerful Brain Protection after Cardiac Arrest
    Robert T Mallet; Fiscal Year: 2013
    ..This hypothesis will be addressed in dogs subjected to ventricular fibrillation cardiac arrest, CPR, defibrillatory countershocks and recovery...
  41. Deep Sequencing for the Detection of Viral Sequences in Primary Progressive Multi
    John D Kriesel; Fiscal Year: 2012
    ..A number of central nervous system viral infections can lead to demyelination, including distemper in dogs and measles (SSPE) and influenza in humans...
  42. PTEN Gene Therapy for Vein Graft Disease
    Christopher D Kontos; Fiscal Year: 2010
    ..grafts;and 2) Compare 6-month aortocoronary saphenous vein graft (SVG) patency rates and intimal hyperplasia in dogs following ex vivo vein graft treatment with AdPTEN, AAV-PTEN, or saline control...
  43. Development of Estrogen Receptor B Selective Receptor Agonists to Treat Neuropath
    ETHAN SAMUEL BURSTEIN; Fiscal Year: 2012
    ..cardiovascular toxicity (hERG channel inhibition, cardiovascular monitoring in conscious, telemetered dogs or monkeys) and repeat dose toxicity studies for 28 days in rodent and non-rodent models...
  44. VEGF receptor-1-mediated protection in dilated cardiomyopathy
    Fabio A Recchia; Fiscal Year: 2013
    ..angiotensin II-induced oxidative stress and markedly attenuates cardiac remodeling and functional derangement in dogs with pacing- induced dilated cardiomyopathy...
  45. Installation of Energy-Efficient Cage Washers for Childrens Hospital Vivarium
    Philip R Johnson; Fiscal Year: 2012
    ..The vivarium houses both large animal species (dogs, pigs, sheep, and rabbits) and CHOP's rodent quarantine facility...
  46. Investigational Safety and Toxicity Studies of Subcutaneous COG1410 for Alzheimer
    MICHAEL PETER VITEK; Fiscal Year: 2013
    ..1 SBIR application will perform the dose range finding studies with subcutaneously administered COG1410 in rats and dogs so as to determine the low, middle and high doses of SC-COG1410 that will be used in Phase 2 SBIR studies...
  47. Alpha Radioimmunotherapy for Lymphoma Treatment
    BRENDA MARIE SANDMAIER; Fiscal Year: 2013
    ..by delivering targeted anti-CD45 radiotherapy using an ?-emitter, astatine-211 (211At), to sites of disease in dogs with spontaneous lymphoma...
  48. Evaluation of NBD Peptides as an Adjunct Therapy for the Treatment of Non-Hodgkin
    PATRICK MICHAEL FLOOD; Fiscal Year: 2010
    ..can safely inhibit aberrant, constitutive NF-?B activity and prolong disease free survival in privately owned dogs with spontaneous, relapsed NHL...
  49. High-Grade Astrocytoma-specific Molecular Targeting
    Waldemar Debinski; Fiscal Year: 2013
    ..Third, six novel monoclonal antibodies (MAb) were generated that recognize specifically IL-13Ra2 in both humans and dogs. Dogs develop spontaneous malignant gliomas and their clinical and pathological and molecular features, including ..
  50. Therapeutic-Expression of a Platelet-Specific Integrin
    DAVID ALLEN WILCOX; Fiscal Year: 2010
    ..A line of Great Pyrenees dogs affected with GT due to an abnormality in allb will serve as a model to test the feasibility for platelet-targeted ..
  51. Erythropoietin Blockade for the Treatment of Cancer
    C Anthony Blau; Fiscal Year: 2012
    ..cells and their progeny allows for CID-dependent blood cell production, predominantly red blood cells, from mice, dogs and humans...
  52. Air Pollution and Cognitive Aging Among Older Women
    Jennifer Weuve; Fiscal Year: 2010
    ..In autopsy studies of dogs and humans, air pollution exposure is associated with Alzheimer-like changes in the brain...
  53. Mechamism of Activation of Oxidative Metabolism in vivo During Exercise
    JESSICA ROSE SPIRES; Fiscal Year: 2012
    ..Experiments in dogs (normal and with altered dehydrogenase activity) will be conducted at rest and during exercise to quantify the ..
  54. Optogenetic Control of Vigilance State Transition
    Luis de Lecea; Fiscal Year: 2013
    ..Studies in mice, dogs and humans have shown that loss-of- function of the hypocretin system results in narcolepsy/cataplexy...
  55. DP ARF Ultrasound for Monitoring Muscle Degeneration in Duchenne Muscular Dystrop
    Caterina M Gallippi; Fiscal Year: 2013
    ..30 Our preliminary data in Golden Retriever Muscular Dystrophy (GRMD) dogs, a relevant model of human DMD,31-36 supports that DP ARF discriminates fibrous deposition in the rectus femoris (..
  56. Clinical Trial of the FAST Real-Time GFR System
    Bruce A Molitoris; Fiscal Year: 2011
    ..This System has been successfully tested under physiologic and AKI conditions in dogs, and shows a close correlation with a research gold standard measure of GFR...
  57. Genetic components influencing the feline - human social bond
    Leslie A Lyons; Fiscal Year: 2011
    ..been linked to genetic variation of the genes within these biological pathways in humans, primates, rodents, and dogs. The objective of this R03 request is to investigate the influence of genetic variation in a cat's role in AAI ..
  58. Achromatopsia - Disease Mechanisms and Cone-Directed Gene Therapy
    Andras Komaromy; Fiscal Year: 2013
    ..for primary defects of the retinal pigment epithelium (RPE) has been demonstrated in several species, including dogs. Because of their successful, stable, and apparently safe transgene expression, these studies are now in Phase 1 ..
  59. A novel in vivo test system to evaluate therapeutic antibodies in dog models of s
    GENEVIEVE HANSEN; Fiscal Year: 2010
    ..antibody drug candidates with sequences compatible with the dog immune system to allow repeated administration in dogs, and (2) their testing for efficacy and safety in a dog model of spontaneous cancer...
  60. Identification of XX DSD Mutations by RNA-seq and Comparative Genomics
    Vicki N Meyers-Wallen; Fiscal Year: 2013
    ..If our hypothesis is correct, we will identify orthologs in XX DSD individuals (humans and dogs) that are evolutionarily conserved, yet contain nucleotides that are different from the reference genomes...
  61. Estrogen receptors in benign prostatic hyperplasia
    TRISTAN MARRINER NICHOLSON; Fiscal Year: 2013
    ..Treatment of male dogs with androgens and estrogens induces earlier onset and more extensive BPH, and male rats treated with T+E2 develop ..
  62. One Health;Epidemiology of natural and deliberate contaminants (infectious and t
    Susan Sanchez; Fiscal Year: 2013
    ..Furthermore, we were the first laboratory to diagnose melamine toxicosis in dogs due to contaminated components in canned pet food...
  63. DIETARY & GENETIC CONTROL OF ROS DAMAGE TO THE LENS
    Norman S Wolf; Fiscal Year: 2010
    ..This work has shown the mechanisms at work in the development of ARC, in mice and rats, and still underway, in dogs and humans...
  64. HYALURONIC ACID/TGF-B COMPOSITE TO TREAT OSTEOARTHRITIS
    STEVEN KINCAID; Fiscal Year: 1991
    ..The left knees of 4 groups of 4 dogs will be immobilized by casts for 56 days. A fifth group of 4 dogs will serve as untreated controls...
  65. Intervention strategies of hemorrhagic colitis and HUS
    Edgar Boedeker; Fiscal Year: 2004
    ..coli (EHEC) infection, in rabbits and dogs, to develop therapeutic regimens to prevent and treat EHEC disease...
  66. Improving Gastrointestinal Recovery after Radiation
    George Georges; Fiscal Year: 2007
    ..syndrome will be given after TBI, and in Aim 2, the drugs will be given before and after TBI to achieve survival of dogs with good GI tract recovery. Based on our prior work in this model, we will begin with a TBI dose of 10 Gy at 0...
  67. GENE THERAPY FOR HEMOPHILIA
    Mark Kay; Fiscal Year: 2005
    ..gene transfer in fetal monkeys, and validate these conditions in neonatal monkeys and neonatal hemophilia A dogs. (#3) Dr...
  68. Gene Therapy for hemophilia using muscle-expressed FVIIa
    Katherine A High; Fiscal Year: 2011
    ..FVIIa following adeno-associated virus (AAV) gene transfer can correct the phenotypic defect in hemophilic mice and dogs. This approach has immunological advantages over Factor IX (FIX) or Factor VIII (FVIII) gene strategies since the ..
  69. Stampidine: A Novel Broad-Spectrum Antiviral Agent
    Taracad Venkatachalam; Fiscal Year: 2003
    ..Pharmacokinetic and toxicity studies of STAMP conducted in mice, rats, cats, and dogs following oral administration of formulated GMP-grade STAMP (25-100 mg/kg/day) as hard gelatin capsules showed ..
  70. REMODELING RESEARCH ANIMAL ROOMS
    DONALD MAUL; Fiscal Year: 1990
    ..animal facility and the quarantine facility at the Veterinary Teaching Hospital (VTH) currently house cats and/or dogs in projects from the departments of Radiology and Radiation Biology, and Clinical Sciences in the College of ..
  71. CLINICAL PHARMACOLOGY CENTER
    Michael Murphy; Fiscal Year: 1991
    ..These studies will be conducted with measurements of blood flow in vascular beds of anesthetized dogs by electromagnetic flowmeters. Studies will also be conducted with isolated canine and rabbit blood vessels...
  72. HEMOSTATIC DEFECTS AND THYROID HORMONE THERAPY
    WINIFRED DODDS; Fiscal Year: 1990
    ..A unique colony of dogs with well- characterized inherited defects and a clinical population of dogs referred for bleeding problems will be ..
  73. Evaluation of Salmonella in Symptomatic and Asymptomatic Pets: Study for the Vet-
    Shelley Rankin; Fiscal Year: 2012
    ..There is a scarcity of information on the prevalence of Salmonella in dogs and much of the available research highlights one particular confounding factor: quite often the observed ..
  74. Environmental Risk Factors and Canine Malignant Lymphoma
    Elizabeth Bertone Johnson; Fiscal Year: 2005
    ..Because canine malignant lymphoma (CML) has been established as a model for NHL and domestic dogs share their living environment with their human owners, a study of environmental exposures and CML provides a ..
  75. DETERMINANTS OF REGIONAL LUNG EXPANSION AND PERFUSION
    Eric Hoffman; Fiscal Year: 1993
    We have recently found strong evidence in dogs and sloths that the intrathoracic position of the heart is a major determinant of regional lung air content, while other studies have demonstrated that vascular geometry (vascular conductance)..
  76. Biomimetic Actinide Decorporation: Characterization and Preclinical Development
    David K Shuh; Fiscal Year: 2010
    ..Extensive efficacy studies in mice have been published and a limited number of tests have been performed in dogs and baboons, establishing that two of the designed agents, 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2- HOPO), are up to 30 ..
  77. Treatment for Canine Diabetic Cataracts
    Milton Wyman; Fiscal Year: 2007
    ..In dogs, DM is characterized by the rapid onset of bilateral sugar cataracts which often result in vision loss...