sus scrofa

Summary

Summary: A species of SWINE, in the family Suidae, comprising a number of subspecies including the domestic pig Sus scrofa domestica.

Top Publications

  1. pmc Patterns of East Asian pig domestication, migration, and turnover revealed by modern and ancient DNA
    Greger Larson
    State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China
    Proc Natl Acad Sci U S A 107:7686-91. 2010
  2. pmc Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR
    Ann Britt Nygard
    University of Copenhagen, Faculty of Life Sciences, Department of Basic Animal and Veterinary Sciences, Division of Genetics and Bioinformatics, Groennegaardsvej 3, 1870 Frederiksberg C, Denmark
    BMC Mol Biol 8:67. 2007
  3. ncbi Worldwide phylogeography of wild boar reveals multiple centers of pig domestication
    Greger Larson
    Henry Wellcome Ancient Biomolecules Centre, University of Oxford, Department of Zoology, South Parks Road OX1 3PS, UK
    Science 307:1618-21. 2005
  4. pmc A snapshot of CNVs in the pig genome
    João Fadista
    Group of Molecular Genetics and Systems Biology, Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, Aarhus University, Tjele, Denmark
    PLoS ONE 3:e3916. 2008
  5. ncbi Evidence of the role of European wild boar as a reservoir of Mycobacterium tuberculosis complex
    Victoria Naranjo
    Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
    Vet Microbiol 127:1-9. 2008
  6. pmc Deciphering the porcine intestinal microRNA transcriptome
    Soroush Sharbati
    Freie Universitat Berlin, Institute of Veterinary Biochemistry, Oertzenweg 19b, 14163 Berlin, Germany
    BMC Genomics 11:275. 2010
  7. pmc Ancient DNA, pig domestication, and the spread of the Neolithic into Europe
    Greger Larson
    Department of Zoology, Henry Wellcome Ancient Biomolecules Centre, South Parks Road, Oxford OX1 3PS, United Kingdom
    Proc Natl Acad Sci U S A 104:15276-81. 2007
  8. pmc MicroRNA expression profiling of the porcine developing brain
    Agnieszka Podolska
    Department of Basic Animal and Veterinary Sciences, Section of Genetics and Bioinformatics, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e14494. 2011
  9. pmc Contrasting mode of evolution at a coat color locus in wild and domestic pigs
    Meiying Fang
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    PLoS Genet 5:e1000341. 2009
  10. pmc The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence
    Lei Zhou
    Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People s Republic of China
    J Virol 83:5156-67. 2009

Detail Information

Publications325 found, 100 shown here

  1. pmc Patterns of East Asian pig domestication, migration, and turnover revealed by modern and ancient DNA
    Greger Larson
    State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing 100193, China
    Proc Natl Acad Sci U S A 107:7686-91. 2010
    ..151 previously uncharacterized specimens) and 18 ancient (representing six East Asian archeological sites) pig (Sus scrofa) DNA sequences sampled across East Asia, we provide evidence for the long-term genetic continuity between modern ..
  2. pmc Selection of reference genes for gene expression studies in pig tissues using SYBR green qPCR
    Ann Britt Nygard
    University of Copenhagen, Faculty of Life Sciences, Department of Basic Animal and Veterinary Sciences, Division of Genetics and Bioinformatics, Groennegaardsvej 3, 1870 Frederiksberg C, Denmark
    BMC Mol Biol 8:67. 2007
    ..Selection of high quality reference genes is of crucial importance for the interpretation of data generated by real-time qPCR...
  3. ncbi Worldwide phylogeography of wild boar reveals multiple centers of pig domestication
    Greger Larson
    Henry Wellcome Ancient Biomolecules Centre, University of Oxford, Department of Zoology, South Parks Road OX1 3PS, UK
    Science 307:1618-21. 2005
    ..In contrast, new genetic data reveal multiple centers of domestication across Eurasia and that European, rather than Near Eastern, wild boar are the principal source of modern European domestic pigs...
  4. pmc A snapshot of CNVs in the pig genome
    João Fadista
    Group of Molecular Genetics and Systems Biology, Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, Aarhus University, Tjele, Denmark
    PLoS ONE 3:e3916. 2008
    ..This CNV snapshot analysis is the first of its kind in the porcine genome and constitutes the basis for a better understanding of porcine phenotypes and genotypes with the prospect of identifying important economic traits...
  5. ncbi Evidence of the role of European wild boar as a reservoir of Mycobacterium tuberculosis complex
    Victoria Naranjo
    Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
    Vet Microbiol 127:1-9. 2008
    ..The European wild boar (Sus scrofa) is frequently considered a spillover or dead end host rather than a true reservoir, and scientific evidence is ..
  6. pmc Deciphering the porcine intestinal microRNA transcriptome
    Soroush Sharbati
    Freie Universitat Berlin, Institute of Veterinary Biochemistry, Oertzenweg 19b, 14163 Berlin, Germany
    BMC Genomics 11:275. 2010
    ..g. intestinal development or disease. Recent studies indicate that miRNAs are key regulators of intestinal development and their aberrant expression leads to intestinal malignancy...
  7. pmc Ancient DNA, pig domestication, and the spread of the Neolithic into Europe
    Greger Larson
    Department of Zoology, Henry Wellcome Ancient Biomolecules Centre, South Parks Road, Oxford OX1 3PS, United Kingdom
    Proc Natl Acad Sci U S A 104:15276-81. 2007
    ..Domestic pigs formed a key component of the Neolithic Revolution, and this detailed genetic record of their origins reveals a complex set of interactions and processes during the spread of early farmers into Europe...
  8. pmc MicroRNA expression profiling of the porcine developing brain
    Agnieszka Podolska
    Department of Basic Animal and Veterinary Sciences, Section of Genetics and Bioinformatics, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e14494. 2011
    ..Considering these similarities, studies examining microRNA expression during porcine brain development could potentially be used to predict the expression profile and role of microRNAs in the human brain...
  9. pmc Contrasting mode of evolution at a coat color locus in wild and domestic pigs
    Meiying Fang
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden
    PLoS Genet 5:e1000341. 2009
    ..diversity at the porcine melanocortin receptor 1 (MC1R) locus, we provide evidence that wild and domestic pig (Sus scrofa) haplotypes from China and Europe are the result of strikingly different selection pressures, and that coat ..
  10. pmc The 30-amino-acid deletion in the Nsp2 of highly pathogenic porcine reproductive and respiratory syndrome virus emerging in China is not related to its virulence
    Lei Zhou
    Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, People s Republic of China
    J Virol 83:5156-67. 2009
    ..RvHB1-ND30 exhibited low virulence for piglets, like RvHB-1/3.9 and the parental virus HB-1/3.9. Therefore, we conclude that the 30-amino-acid deletion is not related to the virulence of the highly pathogenic PRRSV emerging in China...
  11. pmc Comparative analyses by sequencing of transcriptomes during skeletal muscle development between pig breeds differing in muscle growth rate and fatness
    Xiao Zhao
    State Key Laboratory of Biocontrol, Sun Yat Sen University, Guangzhou, Guangdong, People s Republic of China
    PLoS ONE 6:e19774. 2011
    ..The raw data have been submitted to Gene Expression Omnibus (GEO) under series GSE25406...
  12. ncbi Mitochondrial lineages reveal intense gene flow between Iberian wild boars and South Iberian pig breeds
    B Van Asch
    Instituto de Patologia e Imunologia da Universidade do Porto IPATIMUP, Rua Dr Roberto Frias s n, Porto, Portugal
    Anim Genet 43:35-41. 2012
    The phylogeography of wild boars (WB) and domestic pigs (Sus scrofa) has contributed important insights into where and when domestication occurred...
  13. ncbi MicroRNA identity and abundance in porcine skeletal muscles determined by deep sequencing
    M Nielsen
    Department of Genetics and Biotechnology, Aarhus University, DK Tjele, Denmark
    Anim Genet 41:159-68. 2010
    ....
  14. ncbi Genome-wide single nucleotide polymorphism analysis reveals recent genetic introgression from domestic pigs into Northwest European wild boar populations
    D J Goedbloed
    Resource Ecology Group, Wageningen UR, Wageningen, The Netherlands
    Mol Ecol 22:856-66. 2013
    ....
  15. ncbi A genome-wide association scan in pig identifies novel regions associated with feed efficiency trait
    Goutam Sahana
    Department of Molecular Biology and Genetics, Aarhus University, Blichers alle 20, Postboks 50, DK 8830 Tjele, Denmark
    J Anim Sci 91:1041-50. 2013
    ..The study provides a list of SNP associated with FCR and also offers valuable information on the genetic architecture and candidate genes for this trait...
  16. ncbi Animal QTLdb: beyond a repository. A public platform for QTL comparisons and integration with diverse types of structural genomic information
    Zhi Liang Hu
    Department of Animal Science, Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011 3150, USA
    Mamm Genome 18:1-4. 2007
    ..animalgenome.org)...
  17. ncbi Quantitative trait loci analysis for growth and carcass traits in a Meishan x Duroc F2 resource population
    S Sato
    National Livestock Breeding Center, Nishigo, Fukushima 961 8511, Japan
    J Anim Sci 81:2938-49. 2003
    ..quantitative trait loci (<1% genomewise error rate) affecting weight at 30 d and average daily gain on Sus scrofa chromosome (SSC) 6, carcass yield on SSC 7, backfat thickness on SSC 7 and SSC X, vertebra number on SSC 1 and ..
  18. pmc Linkage disequilibrium decay and haplotype block structure in the pig
    Andreia J Amaral
    Animal Breeding and Genomics Centre, Wageningen UR, 6700AH, Wageningen, The Netherlands
    Genetics 179:569-79. 2008
    ..Second, modern breeding programs increased the extent of LD in Europe and caused differences of LD between genomic regions. Large White, Landrace, and Duroc showed evidence of past introgression from Chinese breeds...
  19. pmc LongSAGE analysis of skeletal muscle at three prenatal stages in Tongcheng and Landrace pigs
    Zhonglin Tang
    Department of Gene and Cell Engineering, State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, PR China
    Genome Biol 8:R115. 2007
    ..Here, we describe a genome-wide analysis of differences in prenatal skeletal muscle between Tongcheng (a typical indigenous Chinese breed) and Landrace (a leaner Western breed) pigs...
  20. pmc Analysis of muscle and ovary transcriptome of Sus scrofa: assembly, annotation and marker discovery
    Qinghua Nie
    Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou, GuangDong 510642, People s Republic of China
    DNA Res 18:343-51. 2011
    Pig (Sus scrofa) is an important organism for both agricultural and medical purpose. This study aims to investigate the S. scrofa transcriptome by the use of Roche 454 pyrosequencing...
  21. ncbi Comparative analysis of monocyte subsets in the pig
    Lynsey Fairbairn
    The Roslin Institute and The Royal Dick School of Veterinary Studies, University of Edinburgh, Midlothian EH25 9RG, United Kingdom
    J Immunol 190:6389-96. 2013
    ..The results are discussed in terms of the relevance of the pig as a model for understanding human monocyte function...
  22. pmc Epidemiology, diagnosis, treatment, and control of trichinellosis
    Bruno Gottstein
    Faculty of Medicine, Institute of Parasitology, University of Bern, Bern, Switzerland
    Clin Microbiol Rev 22:127-45, Table of Contents. 2009
    ..The evidence that the disease can be monitored and to some extent controlled with a rigorous reporting and testing system in place should be motivation to expand appropriate programs worldwide...
  23. ncbi Synergistic effects of glutathione and β-mercaptoethanol treatment during in vitro maturation of porcine oocytes on early embryonic development in a culture system supplemented with L-cysteine
    Changyong Choe
    Republic of Korea Animal Genetic Resources Station, National Institute of Animal Science, RDA, Namwon, Korea
    J Reprod Dev 56:575-82. 2010
    ..05). These results suggest that a combination of 1 mM GSH or 25 µM β-ME with 1 mM L-cysteine could be used for production of high quality porcine blastocysts in IVC systems...
  24. ncbi Ancient vs. recent processes as factors shaping the genetic variation of the European wild boar: are the effects of the last glaciation still detectable?
    M Scandura
    Dipartimento di Zoologia e Genetica Evoluzionistica, Universita di Sassari, Via Muroni 25, 07100 Sassari, Italy
    Mol Ecol 17:1745-62. 2008
    ..In this context controlling some populations by hunting is not expected to affect significantly genetic variation in this species...
  25. ncbi Consequences of repeated early isolation in domestic piglets (Sus scrofa) on their behavioural, neuroendocrine, and immunological responses
    Ellen Kanitz
    Research Unit Behavioural Physiology, Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
    Brain Behav Immun 18:35-45. 2004
    ..Using the pig as a suitable animal model, the finding of this study may also have some implications for the etiology of anxiety and depression in humans...
  26. pmc Innate immune responses to human rotavirus in the neonatal gnotobiotic piglet disease model
    Ana M Gonzalez
    Department of Veterinary Preventive Medicine, Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA
    Immunology 131:242-56. 2010
    ..Stimulation of the anti-inflammatory effects of pDCs after the high dose, without increasing their pro-inflammatory impacts, may be critical to reduce further immunopathology during HRV infection...
  27. ncbi The fat mass and obesity-associated (FTO) gene is associated with intramuscular fat content and growth rate in the pig
    Bin Fan
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, USA
    Anim Biotechnol 20:58-70. 2009
    ....
  28. ncbi Identification and characterization of microRNAs from porcine skeletal muscle
    S S Xie
    Huazhong Agricultural University, Wuhan, China
    Anim Genet 41:179-90. 2010
    ..Our results add to existing data on porcine miRNAs and are useful for investigating the biological functions of miRNAs in porcine skeletal muscle development...
  29. pmc Wild boars as sources for infectious diseases in livestock and humans
    X J Meng
    Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, CRC Integrated Life Sciences Building, Blacksburg, VA 24061 0913, USA
    Philos Trans R Soc Lond B Biol Sci 364:2697-707. 2009
    Wild boars (Sus scrofa) are indigenous in many countries in the world. These free-living swine are known reservoirs for a number of viruses, bacteria and parasites that are transmissible to domestic animals and humans...
  30. pmc The contribution of social effects to heritable variation in finishing traits of domestic pigs (Sus scrofa)
    R Bergsma
    Institute for Pig Genetics, Beuningen, The Netherlands
    Genetics 178:1559-70. 2008
    ..Our results suggest that genetic improvement in agriculture can be substantially advanced by redirecting breeding schemes, so as to capture heritable variance due to social effects...
  31. ncbi A linkage map of the porcine genome from a large-scale White Duroc x Erhualian resource population and evaluation of factors affecting recombination rates
    Y Guo
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, China
    Anim Genet 40:47-52. 2009
    ..However, recombination rates on paternal chromosomes were affected by the mating season of the F(1) animals. This could represent an effect of environmental temperature on spermatogenesis...
  32. ncbi Risk factors associated with the prevalence of tuberculosis-like lesions in fenced wild boar and red deer in south central Spain
    Joaquin Vicente
    Instituts de Investigación en Recursos cinegéticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13080 Ciudad Real, Spain
    Vet Res 38:451-64. 2007
    ..factors which investigated associations between the pattern of tuberculosis-like lesions (TBL) in wild boar (Sus scrofa) and red deer (Cervus elaphus) across 19 hunting estates from SCS and an extensive set of variables related to ..
  33. ncbi Unexpected sequence types in livestock associated methicillin-resistant Staphylococcus aureus (MRSA): MRSA ST9 and a single locus variant of ST9 in pig farming in China
    Jaap A Wagenaar
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, P O Box 80 165, 3508 TD Utrecht, The Netherlands
    Vet Microbiol 139:405-9. 2009
    ..The study confirms that livestock may act as a reservoir for MRSA...
  34. ncbi Progress in the control of bovine tuberculosis in Spanish wildlife
    Christian Gortazar
    IREC CSIC UCLM JCCM, Ronda de Toledo s n, Ciudad Real 13071, Spain
    Vet Microbiol 151:170-8. 2011
    ..Finally, preliminary vaccination and challenge experiments suggested that a single oral BCG vaccination may protect wild boar from infection by a virulent M. bovis field strain...
  35. ncbi A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population
    G Liu
    Animal Breeding and Husbandry Group, Institute of Animal Science, University of Bonn, Endenicher Allee 15, 53115 Bonn, Germany
    Anim Genet 38:241-52. 2007
    ..Two QTL for trait backfat thickness were detected on SSC2; a significant paternal effect was found for a QTL in the IGF2 region while another QTL in the middle of SSC2 showed Mendelian expression...
  36. ncbi Confirmation of QTL on porcine chromosomes 1 and 8 influencing leukocyte numbers, haematological parameters and leukocyte function
    E Wattrang
    Department of Molecular Biosciences, Section of Veterinary Immunology and Virology, Swedish University of Agricultural Sciences, Box 588, SE 751 23 Uppsala, Sweden
    Anim Genet 36:337-45. 2005
    ..05). The results confirm the involvement of earlier identified regions of SSC1 and SSC8 on porcine immune parameters and some candidate genes were suggested...
  37. pmc Gene expression profile suggests that pigs (Sus scrofa) are susceptible to Anaplasma phagocytophilum but control infection
    Ruth C Galindo
    Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, Ciudad Real 13005, Spain
    Parasit Vectors 5:181. 2012
    ..The objective of this research was to characterize gene expression in pigs (Sus scrofa) naturally and experimentally infected with A...
  38. ncbi Integrating comparative expression profiling data and association of SNPs with Salmonella shedding for improved food safety and porcine disease resistance
    J J Uthe
    Department of Animal Science, Iowa State University, Ames, IA 50014, USA
    Anim Genet 42:521-34. 2011
    ..These associations provide new information about the mechanisms of porcine host response to Salmonella and may be useful in improving genetic resistance to this bacterium...
  39. pmc Multi-locus analysis reveals a different pattern of genetic diversity for mitochondrial and nuclear DNA between wild and domestic pigs in East Asia
    Yin Qiu Ji
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    PLoS ONE 6:e26416. 2011
    ....
  40. ncbi Brucellosis in the United States: role and significance of wildlife reservoirs
    S C Olsen
    Bacterial Disease of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, USDA, Ames, IA 50010, USA
    Vaccine 28:F73-6. 2010
    ..Although some tools are currently available for use in the wildlife reservoirs, development of new vaccines, diagnostics, and management procedures will most likely be needed for effective control of brucellosis...
  41. pmc Surveillance of bovine tuberculosis and risk estimation of a future reservoir formation in wildlife in Switzerland and Liechtenstein
    Janne Marie Schöning
    Centre for Fish and Wildlife Health FIWI, Vetsuisse Faculty, University of Bern, Bern, Switzerland
    PLoS ONE 8:e54253. 2013
    ..data for Swiss and Liechtenstein wildlife are not available so far, although two native species, wild boar (Sus scrofa) and red deer (Cervus elaphus elaphus), act as bTB reservoirs elsewhere in continental Europe...
  42. ncbi Most of the benefits from genomic selection can be realized by genotyping a small proportion of available selection candidates
    M Henryon
    Danish Agriculture and Food Council, Pig Research Centre, Axeltorv 3, 1609 Copenhagen V, Denmark
    J Anim Sci 90:4681-9. 2012
    ..Our findings should benefit breeders because they suggest that large investments in genotyping are not required to reap most of the benefits from genomic selection...
  43. ncbi Quantitative trait loci for fatty acid composition in longissimus dorsi and abdominal fat: results from a White Duroc x Erhualian intercross F2 population
    T Guo
    Key Laboratory for Animal Biotechnology of Jiangxi Province, Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, China
    Anim Genet 40:185-91. 2009
    ..Chinese Erhualian alleles were associated with increased ratios of MUFA to saturated fatty acid at most of the QTL detected, showing beneficial effect in terms of human health...
  44. ncbi Identification of a single killer immunoglobulin-like receptor (KIR) gene in the porcine leukocyte receptor complex on chromosome 6q
    Jennifer G Sambrook
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, England, UK
    Immunogenetics 58:481-6. 2006
    ..identified by comparative genomics the first and possibly only KIR gene, named KIR2DL1, in the domesticated pig (Sus scrofa) allowing further evolutionary comparisons to be made...
  45. ncbi Seroprevalence study in forestry workers from eastern Germany using novel genotype 3- and rat hepatitis E virus-specific immunoglobulin G ELISAs
    Paul Dremsek
    Friedrich Loeffler Institut, Federal Research Institute for Animal Health, OIE Collaborating Centre for Zoonoses in Europe, Institute for Novel and Emerging Infectious Diseases, Südufer 10, 17493, Greifswald Insel Riems, Germany
    Med Microbiol Immunol 201:189-200. 2012
    ..The epidemiological role of ratHEV in human disease should be assessed in a large-scale study of risk and non-risk groups...
  46. ncbi Identification and comparison of microRNAs from skeletal muscle and adipose tissues from two porcine breeds
    Hong yi Li
    Guangdong Provincial Key Laboratory of Agro animal Genomics and Molecular Breeding, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642, China
    Anim Genet 43:704-13. 2012
    ..The great diversity of miRNA composition and expression levels both between breeds and between tissues suggests that a complex regulatory network exists in porcine subcutaneous fat development...
  47. ncbi Why working with porcine circulating serum amyloid A is a pig of a job
    L Soler
    Department of Animal Medicine and Surgery, University of Murcia, 30100 Espinardo, Murcia, Spain
    J Theor Biol 317:119-25. 2013
    ..It is concluded that pig systemic SAA is unique compared to other species, which raises questions about the proposed importance of acute phase SAA in HDL metabolism during inflammation in this species...
  48. pmc Porcine kobuvirus in wild boars (Sus scrofa)
    Gabor Reuter
    Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ANTSZ Regional Institute of State Public Health Service, Szabadság út 7, 7623, Pecs, Hungary
    Arch Virol 158:281-2. 2013
    Fecal samples (N = 10) from 6- to 8-week-old wild boar piglets (Sus scrofa), collected from an animal park in Hungary in April 2011, were analyzed using viral metagenomics and complete genome sequencing...
  49. ncbi A chronologic review of mature oocyte vitrification research in cattle, pigs, and sheep
    S F Mullen
    The World Egg Bank, Phoenix, Arizona, USA
    Theriogenology 78:1709-19. 2012
    ..Messenger RNA levels are reportedly altered in sheep oocytes as a result of vitrification, and damage to the cytoskeleton is common across species...
  50. ncbi Lesions associated with Mycobacterium tuberculosis complex infection in the European wild boar
    María Paz Martín-Hernando
    Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
    Tuberculosis (Edinb) 87:360-7. 2007
    ..and distribution of lesions in 127 Mycobacterium tuberculosis Complex culture positive European wild boars (Sus scrofa), and use this information to discuss the role of this wildlife species in TB epidemiology in Mediterranean ..
  51. ncbi Genome-wide identification of quantitative trait loci for carcass composition and meat quality in a large-scale White Duroc x Chinese Erhualian resource population
    J Ma
    Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang 330045, China
    Anim Genet 40:637-47. 2009
    ..White Duroc alleles at a majority of QTL detected were favourable for carcass composition, while favourable QTL alleles for meat quality originated from both White Duroc and Erhualian...
  52. pmc Involvement of complexin 2 in docking, locking and unlocking of different SNARE complexes during sperm capacitation and induced acrosomal exocytosis
    Pei Shiue J Tsai
    Department of Farm Animal Health, Graduate School of Animal Health, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 7:e32603. 2012
    ..The possibility to study separate and dynamic interactions between SNARE proteins, complexin and Ca(2+) which are all involved in AE make sperm an ideal model for studying exocytosis...
  53. ncbi L-carnitine enhances oocyte maturation and development of parthenogenetic embryos in pigs
    G Q Wu
    Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, People s Republic of China
    Theriogenology 76:785-93. 2011
    ....
  54. ncbi Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research
    Birgitte R Kornum
    Neurobiology Research Unit and Center for Integrated Molecular Brain Imaging, N9201, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen East, Denmark
    Neurosci Biobehav Rev 35:437-51. 2011
    ..However, most tasks have only been established at a single research facility, and would benefit from further validation. This review presents the cognitive tasks that have been developed for pigs, their validation, and their current use...
  55. ncbi Zinc resistance of Staphylococcus aureus of animal origin is strongly associated with methicillin resistance
    Lina M Cavaco
    Research Group for Antimicrobial Resistance and Molecular Epidemiology, National Food Institute, Technical University of Denmark, Copenhagen, Denmark
    Vet Microbiol 150:344-8. 2011
    ..This study showed that zinc resistance and the czrC gene are widespread among CC398 MRSA isolates. This suggests that the use of zinc in feed might have contributed to the emergence of MRSA...
  56. ncbi Quantitative trait loci for production traits in pigs: a combined analysis of two Meishan x Large White populations
    Y M Guo
    Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin Biocentre, Roslin, Midlothian, UK
    Anim Genet 39:486-95. 2008
    ..There were also a number of significant interactions between detected QTL effects and population...
  57. ncbi Porcine reproductive and respiratory syndrome virus induces pronounced immune modulatory responses at mucosal tissues in the parental vaccine strain VR2332 infected pigs
    Cordelia Manickam
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, Department of Veterinary Preventive Medicine, The Ohio State University, 1680 Madison Avenue, Wooster, OH 44691, USA
    Vet Microbiol 162:68-77. 2013
    ..The NK cell-mediated cytotoxicity was significantly reduced in infected pigs. In addition, increased population of immunosuppressive T-regulatory cells (Tregs) and associated cytokines were also observed in VR2332 strain infected pigs...
  58. pmc African swine fever virus isolate, Georgia, 2007
    Rebecca J Rowlands
    Institute for Animal Health, Pirbright, UK
    Emerg Infect Dis 14:1870-4. 2008
    ..One possibility for the spread of disease to Georgia is that pigs were fed ASFV-contaminated pork brought in on ships and, subsequently, the disease was disseminated throughout the region...
  59. ncbi Free-ranging wild boar: a disease threat to domestic pigs in Switzerland?
    Natacha Wu
    Centre for Fish and Wildlife Health, Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Postfach 8466, CH 3001 Bern, Switzerland
    J Wildl Dis 47:868-79. 2011
    The risk of transmission of pathogens from free-ranging wild boars (Sus scrofa scrofa) to outdoor domestic pigs (S. scrofa domesticus) is of increasing concern in many European countries...
  60. ncbi Hypoxia-inducible factor-1 is a positive regulator of Sox9 activity in femoral head osteonecrosis
    Chi Zhang
    Department of Research, Texas Scottish Rite Hospital for Children, Dallas, TX, USA
    Bone 48:507-13. 2011
    ..We speculate that HIF-1α upregulation of Sox9 activity may have a chondroprotective role following femoral head ischemia...
  61. ncbi The insulin-like growth factor 2 (IGF2) gene intron3-g.3072G>A polymorphism is not the only Sus scrofa chromosome 2p mutation affecting meat production and carcass traits in pigs: evidence from the effects of a cathepsin D (CTSD) gene polymorphism
    L Fontanesi
    DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
    J Anim Sci 88:2235-45. 2010
    ..However, for practical applications, because the CTSD gene should not be imprinted (we obtained this information from expression analysis in adult skeletal muscle), the different modes of inheritance of the 2 genes have to be considered...
  62. ncbi Porcine T-helper and regulatory T cells exhibit versatile mRNA expression capabilities for cytokines and co-stimulatory molecules
    Tobias Käser
    Institute of Immunology, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinarplatz 1, 1210 Vienna, Austria
    Cytokine 60:400-9. 2012
    ..In contrast, Tregs appear to fulfil mainly immunosuppressive functions characterized by increased production of IL-10, IL-35, CD40L, and CD25...
  63. ncbi Wild boars as an important reservoir for foodborne pathogens
    Silke Wacheck
    Faculty of Veterinary Medicine, Institute of Food Hygiene and Technology, Ludwig Maximilians University, Munich, Germany
    Foodborne Pathog Dis 7:307-12. 2010
    ..This study shows that wild boars are frequent carriers of foodborne pathogens. High wild boar densities and increasing popularity of outdoor ranging of pigs may intensify the risk of transmission of these pathogens to fattening pigs...
  64. ncbi Tick-borne disease agents in various wildlife from Mississippi
    Ashley H Castellaw
    Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA
    Vector Borne Zoonotic Dis 11:439-42. 2011
    ..Whole blood and serum were tested from white-tailed deer (WTD; Odocoileus virginianus) and feral swine (Sus scrofa); serum was tested from raccoons (Procyon lotor) and opossums (Didelphis virginiana)...
  65. ncbi Impact of heart valve decellularization on 3-D ultrastructure, immunogenicity and thrombogenicity
    Jianye Zhou
    Thoracic, Cardiac and Vascular Surgery, University Hospital Tubingen, 72076 Tubingen, Germany
    Biomaterials 31:2549-54. 2010
    ..From our experiment, sodium deoxycholate enables cell removal with almost complete preservation of ECM structures. And all of these four decellularization protocols affected human immunological response and increased thrombogenicity...
  66. ncbi Identification of suitable endogenous control microRNA genes in normal pig tissues
    Yiren Gu
    Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya an, China
    Anim Sci J 82:722-8. 2011
    ..We envision that these results will serve as a valuable reference for other studies aimed at measuring tissue-specific miRNA abundance in porcine samples...
  67. pmc Whole-genome SNP association analysis of reproduction traits in the Finnish Landrace pig breed
    Pekka Uimari
    Agrifood Research Finland, MTT, Biotechnology and Food Research, Jokioinen, Finland
    Genet Sel Evol 43:42. 2011
    ..The purpose of this study was to identify SNP associated with reproduction traits in the Finnish Landrace pig breed using the Illumina PorcineSNP60 BeadChip...
  68. ncbi Anaplasma spp. in wild mammals and Ixodes ricinus from the north of Spain
    Aranzazu Portillo
    Área de Enfermedades Infecciosas Centro de Rickettsiosis y Enfermedades Transmitidas por Artrópodos Vectores, Hospital San Pedro CIBIR, Logrono, Spain
    Vector Borne Zoonotic Dis 11:3-8. 2011
    ..Further, it seems that the Ap-variant 1 is circulating among I. ricinus ticks from the North of Spain more frequently than the A. phagocytophilum strain associated to human anaplasmosis...
  69. ncbi A review of viral diseases of the European wild boar: effects of population dynamics and reservoir rôle
    Francisco Ruiz-Fons
    Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
    Vet J 176:158-69. 2008
    ..The focus is on those viral diseases of domestic swine and wild boars that are included as notifiable by the Office International des Epizooties (OIE)...
  70. pmc Slaughterhouse pigs are a major reservoir of Streptococcus suis serotype 2 capable of causing human infection in southern Vietnam
    Thi Hoa Ngo
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS ONE 6:e17943. 2011
    ..suis serotype 2 capable of causing human infection in southern Vietnam. Strict hygiene at processing facilities, and health education programs addressing food safety and proper handling of pork should be encouraged...
  71. pmc Traits associated with innate and adaptive immunity in pigs: heritability and associations with performance under different health status conditions
    Mary Clapperton
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian, EH25 9PS, UK
    Genet Sel Evol 41:54. 2009
    ....
  72. pmc Transcriptome analysis of porcine PBMCs after in vitro stimulation by LPS or PMA/ionomycin using an expression array targeting the pig immune response
    Yu Gao
    INRA, UMR 1313 de Génétique Animale et Biologie Intégrative, Domaine de Vilvert, 78350 Jouy en Josas, France
    BMC Genomics 11:292. 2010
    ..In order to address questions related to immunity and resistance to disease in pig, it is necessary to increase knowledge on its immune system and to produce efficient tools dedicated to this species...
  73. ncbi Two outbreaks of classical swine fever in wild boar in France
    F Pol
    Agence Française de Sécurité Sanitaire des Aliments Laboratorie d Etudes et de Recherches Avicoles Porcines et Piscicoles Unité de Virologie et Immunologie Porcines, Laboratorie National de Référence pour les Pestes Porcines, Zoopole, Ploufragan, France
    Vet Rec 162:811-6. 2008
    ....
  74. pmc Pathology of gastrointestinal organs in a porcine model of cystic fibrosis
    David K Meyerholz
    Department of Pathology, Howard Hughes Medical Institute, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Pathol 176:1377-89. 2010
    ..Thus, mucus cell hyperplasia and mucus accumulation play prominent roles in early disease. Our findings also have implications for CF lung disease, and they lay the foundation for a better understanding of CF pathogenesis...
  75. ncbi Preventive vaccination contributes to control classical swine fever in wild boar (Sus scrofa sp.)
    S Rossi
    Wildlife Sanitary Unit Unité Sanitaire de la Faune, Game and Wildlife Agency Office National de la Chasse et de la Faune Sauvage, 05000 Gap, France
    Vet Microbiol 142:99-107. 2010
    ..attenuated vaccine has been experimented in Europe in order to control classical swine fever (CSF) in Wild Boar (Sus scrofa sp.)...
  76. ncbi Serotype distribution and production of muramidase-released protein, extracellular factor and suilysin by field strains of Streptococcus suis isolated in the United States
    Nahuel Fittipaldi
    Groupe de Recherche sur les Maladies Infectieuses du Porc and Centre de Recherche en Infectiologie Porcine, Faculte de Medecine Veterinaire, Universite de Montreal, St Hyacinthe, QC J2S 7C6, Canada
    Vet Microbiol 139:310-7. 2009
    ..On the other hand, our results for the U.S. S. suis isolates are similar to those reported for Canadian strains, suggesting a common status in North America...
  77. ncbi Induced pluripotent stem cells from swine (Sus scrofa): why they may prove to be important
    R Michael Roberts
    Division of Animal Sciences, University of Missouri, Columbia, MO, USA
    Cell Cycle 8:3078-81. 2009
    ....
  78. pmc Immunohistochemical study of pig retinal development
    Jasenka Guduric-Fuchs
    Centre for Vision and Vascular Sciences, Queen s University Belfast, United Kingdom
    Mol Vis 15:1915-28. 2009
    ..The purpose of this study was to characterize retinal histology in the developing and mature pig retina using antibodies to well established retinal cell markers commonly used in rodents...
  79. pmc Hyposecretion of fluid from tracheal submucosal glands of CFTR-deficient pigs
    Nam Soo Joo
    Cystic Fibrosis Research Laboratory, Stanford University, Stanford, California 94305 2130, USA
    J Clin Invest 120:3161-6. 2010
    ..These data are a step toward determining whether gland secretory defects contribute to CF airway disease...
  80. pmc Identification of QTL with effects on intramuscular fat content and fatty acid composition in a Duroc x Large White cross
    Marie Pierre Sanchez
    INRA, UR337 Station de Génétique Quantitative et Appliquée, F 78350 Jouy en Josas, France
    BMC Genet 8:55. 2007
    ..The detection was performed in an experimental F2 Duroc x Large White population first by segregation analysis, then by QTL mapping using additional molecular information...
  81. ncbi MicroRNA expression profiles of porcine skeletal muscle
    B Zhou
    Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, No 1 Weigang, Nanjing, China
    Anim Genet 41:499-508. 2010
    ..These results provide a valuable resource for investigators interested in post-transcriptional gene regulation in pigs and related animals...
  82. ncbi Comparative analysis of progenitor cells isolated from the iris, pars plana, and ciliary body of the adult porcine eye
    Angus Macneil
    Division of Molecular Therapy, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL UK
    Stem Cells 25:2430-8. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  83. ncbi Severe hepatitis E virus infection after ingestion of uncooked liver from a wild boar
    Hiroyuki Matsuda
    J Infect Dis 188:944. 2003
  84. ncbi MicroRNA identity and abundance in developing swine adipose tissue as determined by Solexa sequencing
    Guoxi Li
    Laboratory of Animal Fat Deposition and Muscle Development, Northwest A and F University, Yangling, Shaanxi Province 712100, PR China
    J Cell Biochem 112:1318-28. 2011
    ..Our results expand the number of known porcine miRNAs and provide a thorough account of the miRNA transcriptome in porcine adipose tissue...
  85. pmc Analysis of imprinted gene expression in normal fertilized and uniparental preimplantation porcine embryos
    Chi Hun Park
    SooAm Biotech Research Foundation, Seoul, Republic of Korea
    PLoS ONE 6:e22216. 2011
    ..In addition we believe that imprinted expression occurs in at least four genes, namely H19, IGF2, XIST and PEG10 in porcine blastocyst stage embryos...
  86. ncbi Pig bone marrow-derived macrophages resemble human macrophages in their response to bacterial lipopolysaccharide
    Ronan Kapetanovic
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    J Immunol 188:3382-94. 2012
    ..These results establish pig BMDM as an alternative tractable model for the study of macrophage transcriptional control...
  87. ncbi Mitochondrial haplotypes of European wild boars with 2n = 36 are closely related to those of European domestic pigs with 2n = 38
    M Fang
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, S 751 24 Uppsala, Sweden
    Anim Genet 37:459-64. 2006
    ....
  88. pmc XMAP215 is a processive microtubule polymerase
    Gary J Brouhard
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Cell 132:79-88. 2008
    ..The similarities between XMAP215 and formins, actin polymerases, suggest that processive tip tracking is a common mechanism for stimulating the growth of cytoskeletal polymers...
  89. ncbi Comparison of luteinizing hormone and steroid hormone secretion during the peri- and post-ovulatory periods in Mangalica and Landrace gilts
    Istvan Egerszegi
    Research Institute for Animal Breeding and Nutrition, 2053 Herceghalom, Gesztenyés út 1, Hungary
    J Reprod Dev 49:291-6. 2003
    ..17.8 +/- 5.0, P<0.05). In our experiment, there was no evidence that differences in the secretion of analysed hormones during the peri- and post-ovulatory periods are a possible cause of usually lower fecundity in Mangalica gilts...
  90. ncbi Bovine tuberculosis in wild boar (Sus scrofa), red deer (Cervus elaphus) and cattle (Bos taurus) in a Mediterranean ecosystem (1992-2004)
    J Hermoso De Mendoza
    Patología Infecciosa, Departamento de Medicina y Sanidad Animal, Facultad de Veterinaria, Universidad de Extremadura, Caceres, Spain
    Prev Vet Med 74:239-47. 2006
    ..These findings, as well as recent history of game estates management and descriptive epidemiology field work, throw light on the rise and maintenance of these epizootics...
  91. ncbi Persistence of pseudorabies virus in feral swine populations
    Joseph L Corn
    Southeastern Cooperative Wildlife Disease Study, University of Georgia, Athens 30602, USA
    J Wildl Dis 40:307-10. 2004
    ..Consistent results from latex agglutination tests conducted in the field and laboratory demonstrated that this test was useful as a rapid and reliable diagnostic tool when used in the field...
  92. ncbi Porcine induced pluripotent stem cells produce chimeric offspring
    Franklin D West
    Regenerative Bioscience Center, University of Georgia, Athens, Georgia 30602, USA
    Stem Cells Dev 19:1211-20. 2010
    ....
  93. ncbi Serologic tests for detecting antibodies against Mycobacterium bovis and Mycobacterium avium subspecies paratuberculosis in Eurasian wild boar (Sus scrofa scrofa)
    Mariana Boadella
    IREC National Wildlife Research Institute CSIC UCLM JCCM, Ronda de Toledo s n, 13071 Ciudad Real, Spain
    J Vet Diagn Invest 23:77-83. 2011
    New tools to detect exposure of free-range Eurasian wild boar (Sus scrofa scrofa) to pathogenic mycobacteria would be valuable for improved disease surveillance and wildlife management...
  94. pmc Neuronal genes for subcutaneous fat thickness in human and pig are identified by local genomic sequencing and combined SNP association study
    Kyung Tai Lee
    Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, Rural Development Administration, Suwon, Republic of Korea
    PLoS ONE 6:e16356. 2011
    ..These results provide strong support for a major involvement of the CNS in the genetic predisposition to a common form of obesity...
  95. ncbi Molecular identification of Trichuris vulpis and Trichuris suis isolated from different hosts
    Cristina Cutillas
    Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Sevilla, Profesor García González s n, Sevilla, Spain
    Parasitol Res 100:383-9. 2007
    Trichuris suis was isolated from the cecum of two different hosts (Sus scrofa domestica -- swine and Sus scrofa scrofa -- wild boar) and Trichuris vulpis from dogs in Sevilla, Spain...
  96. ncbi Retrospective analysis of the oral immunisation of wild boar populations against classical swine fever virus (CSFV) in region Eifel of Rhineland-Palatinate
    Stefan von Rüden
    Institute for Virology, University of Veterinary Medicine Hannover, Hannover, Germany
    Vet Microbiol 132:29-38. 2008
    ..The last virus-positive pig was found 13 months after start of o.i...
  97. ncbi The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs
    L Fontanesi
    DIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F lli Rosselli 107, 42100 Reggio Emilia, Italy
    Anim Genet 40:90-3. 2009
    ..00001, P<0.001 and P<0.0001, considering all animals or only two- or three-generation unrelated animals respectively), indicating association between the analysed FTO marker and intermuscular fat deposition...
  98. ncbi Antimicrobial-resistant faecal Escherichia coli in wild mammals in central Europe: multiresistant Escherichia coli producing extended-spectrum beta-lactamases in wild boars
    I Literak
    Department of Biology and Wildlife Diseases, Faculty of Veterinary Hygiene and Ecology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
    J Appl Microbiol 108:1702-11. 2010
    ..To determine the presence of antibiotic-resistant faecal Escherichia coli in populations of wild mammals in the Czech Republic and Slovakia...
  99. ncbi Gene expression profiles of European wild boar naturally infected with Mycobacterium bovis
    Ruth C Galindo
    Instituto de Investigacion en Recursos Cinegeticos IREC CSIC UCLM JCCM, Ciudad Real, Spain
    Vet Immunol Immunopathol 129:119-25. 2009
    ..Gene expression studies in naturally infected wildlife reservoirs of bovine tuberculosis are important for functional genomics and vaccine studies to aid in disease control in wildlife...
  100. ncbi Magnetic resonance imaging analysis of right ventricular pressure-volume loops: in vivo validation and clinical application in patients with pulmonary hypertension
    Titus Kuehne
    Department of Congenital Heart Diseases and Pediatric Cardiology, German Heart Institute, Augustenburger Platz 1, Berlin 13353 Germany
    Circulation 110:2010-6. 2004
    ....
  101. ncbi Hemodynamic effects of vacuum-assisted closure therapy in cardiac surgery: assessment using magnetic resonance imaging
    Rainer Petzina
    Department of Medicine, Lund University Hospital, Lund, Sweden
    J Thorac Cardiovasc Surg 133:1154-62. 2007
    ....

Research Grants70

  1. Commercial Feasibility Assessment of Pancreatic Islet Progenitor Cell Technology
    Kelvin Brockbank; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis Model
    Aliye Uc; Fiscal Year: 2010
    ..We produced pigs (Sus scrofa) with a targeted disruption of both cystic fibrosis transmembrane conductance regulator (CFTR) alleles...
  3. Biomechanical and Molecular Mechanisms in Alveolar Bone Development
    TRACY POPOWICS; Fiscal Year: 2008
    ..these experimental conditions. Taken together, these studies will provide fundamental new information about how tooth loading modifies alveolar bone in newly erupted teeth and promotes adaptive tooth support. ..
  4. CRYOPRESERVATION OF ARTICULAR CARTILAGE BY VITRIFICATION
    Kelvin Brockbank; Fiscal Year: 2003
    ..The U.S. market for cartilage repair products is predicted to exceed 90,000 units and $248 million in the near future. ..
  5. Engineered Cartilage Storage and Transport Solution
    Kelvin Brockbank; Fiscal Year: 2005
    ..These studies will lead to the development and commercialization of Unisol formulations specifically designed for cold storage of tissue engineered cartilage constructs. ..
  6. Freeze-Dried, Viable Allogeneic Heart Valves
    Kelvin Brockbank; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  7. Feasibility of Unfrozen Sub-zero Storage of Mammalian Tissues with Insect Anti-Fr
    Kelvin Brockbank; Fiscal Year: 2008
    ....
  8. Feasibility of Hypothermic Liver Perfusion
    Kelvin Brockbank; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  9. IMPROVED ALLOGRAFT HEART VALVE PRESERVATION
    Kelvin Brockbank; Fiscal Year: 2003
    ..It is anticipated that modification or reduction of ice formation in cryopreserved valves should decrease the need for reoperation due to structural deterioration and calcification in allograft recipients. ..
  10. BONE GROWTH, PERIOSTEAL MIGRATION AND MUSCLE FUNCTION
    Susan Herring; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  11. MECHANICAL ENVIRONMENT IN MANDIBULAR DISTRACTION
    Susan Herring; Fiscal Year: 2006
    ....
  12. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2009
    ..abstract_text> ..
  13. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
    ....
  14. NO-MEDIATED MODIFICATION OF NMDA RECEPTOR DURING HYPOXIA
    Om Mishra; Fiscal Year: 2008
    ..abstract_text> ..
  15. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  16. NO-MEDIATED MODIFICATION OF NMDA RECEPTOR DURING HYPOXIA
    Om Mishra; Fiscal Year: 2006
    ..abstract_text> ..
  17. Nitric Oxide Tolerance in Smooth Muscle
    William Perkins; Fiscal Year: 2005
    ..We will use a combination of pharmacological probes and novel antisense oligomers to determine the mechanism by which chronic NO treatment decreases the expression and activity of sGC subunits and cGK isoforms. ..
  18. Ischemic Arrest, Cytokines, and Organ Dysfunction
    James Niemann; Fiscal Year: 2008
    ..In aim 3, the effect of anti-TNF therapy on long-term survival and neurologic outcome will be evaluated. [unreadable] [unreadable]..
  19. Arginine and Ovine Model for Fetal Growth Restriction
    Guoyao Wu; Fiscal Year: 2007
    ..This will ultimately promote favorable pregnancy outcomes while saving billions of healthcare dollars in the U.S. and worldwide. [unreadable] [unreadable] [unreadable]..
  20. Reproduction of Transgenic Pigs by Nuclear Transplantation
    Randall S Prather; Fiscal Year: 2010
    ..of DNA methylation changes during development will provide clues as to the process of imprinting in Sus scrofa. To that end we propose to bring to bear the most relevant technologies into a systems or integrated approach, i...
  21. STRETCH-INDUCED CYCLOOXYGENASE-2 IN UROTHELIAL CELLs
    Stephen Nakada; Fiscal Year: 2005
    ..abstract_text> ..
  22. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  23. TRPV4 Initiates Ventilator Induced Lung Injury
    James C Parker; Fiscal Year: 2010
    ..and that lung PAR1 and PAR2 activation peptidesincrease lung vascular permeability in TRPV4+/+ mice ventilated with high airway pressures but not in TRPV4-/- mice, or either genotype ventilated with low airway pressures ..
  24. Enhanced Primary Repair of Ligament Injuries
    Martha Murray; Fiscal Year: 2008
    ..In the third aim, the optimized scaffolds will be tested in an in vivo canine ACL non-union model. Information gained in each of these aims will serve to improve our understanding of mechanisms of ligament healing. ..
  25. Formation of the Enamel-Dentin Interface
    Elia Beniash; Fiscal Year: 2010
    ..abstract_text> ..
  26. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  27. Improved MRI techniques for measurement of absolute temperature distributions
    NICHOLAS TODD; Fiscal Year: 2008
    ..A temporally constrained reconstruction algorithm has been shown to be capable of reducing scan time and can also be implemented with any pulse sequence. [unreadable] [unreadable] [unreadable]..
  28. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  29. Bridges to the Doctorate in Reproductive Biology
    Fuller Bazer; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. INTERACTION BETWEEN BLASTOCYST AND UTERINE ENDOMETRIUM
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2010
    ..Together these studies are expected to provide information on two key events in early pregnancy, the formation of an early placenta and immediate maternal responses to the presence of a tiny embryo attaching to her uterine wall. ..
  31. Improving Institutional Animal Resources at MUSC
    MARVIN SWINDLE; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  32. Pulsed Electron Avalanche Knife: Intraocular Microsurg.
    Daniel Palanker; Fiscal Year: 2006
    ..The low cost and small size of this system combined with high precision, reliability and versatility should allow for a widespread acceptance into operating practice. ..
  33. Relationship between diet and sex of offspring
    Robert Roberts; Fiscal Year: 2008
    ..abstract_text> ..
  34. Light dosimetry for esophageal photodynamic therapy
    Linda Jones; Fiscal Year: 2007
    ..As esophageal photodynamic therapy is improved, it is likely to be used more often as an alternative to esophagectomy. [unreadable] [unreadable] [unreadable]..
  35. Prostanoids and hypoxic neonatal pulmonary hypertension
    CANDICE FIKE; Fiscal Year: 2009
    ..The goal of this project is to help us understand why infants develop pulmonary hypertension, determine what happens in the lung blood vessels during disease development, and develop treatments for this disease. ..
  36. Mechanical Injury to Lung Endothelium
    James Parker; Fiscal Year: 2001
    ....
  37. MMP-20 AND MMP-20 DOMAIN FUNCTION IN FORMING ENAMEL
    John Bartlett; Fiscal Year: 2006
    ..This application builds on results from a highly productive R29 grant (DE12098). ..
  38. Role of CRH in skin physiology and pathology
    Andrzej Slominski; Fiscal Year: 2004
    ..g., melanocytes and keratinocytes, and test the role of CRH/CRH-R1 axis in the regulation of human hair growth. ..
  39. DEVELOPING BSL3 ANIMAL FACILITIES AT MUSC
    MARVIN SWINDLE; Fiscal Year: 2004
    ..The facility will be in full compliance with CDC and NIH regulations for performing this type of research. ..
  40. JEOL 1230 TEM and BOC Edwards Vacuum Evaporator
    Michael Welsh; Fiscal Year: 2004
    ..McCray will be involved with gene transfer using lentiviral vectors. Tobacman will study the structure of short actin filaments. Zabner will examine the morphology of Adeno-associated virus. ..
  41. High Intensity Ultrasound in Gastroenterology
    JOO HWANG; Fiscal Year: 2003
    ..It is anticipated that this work will help to gain a better understanding of the mechanisms of HIFU and its potential role for other GI applications such as tumor therapy. ..
  42. IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    MARVIN SWINDLE; Fiscal Year: 2003
    ....
  43. OVARIAN LDL RECEPTOR AND STAR GENE REGULATION
    HOLLY LAVOIE; Fiscal Year: 2003
    ..These studies will promote our understanding of how multiple genes are coordinated by different trophic factors in the ovary during follicular differentiation and add to our understanding of mechanisms of infertility. ..
  44. HIV/SIV ENVELOPE GLYCOPROTEIN EFFECTS ON ENDOTHELIA
    Changyi Chen; Fiscal Year: 2002
    ....
  45. AIRWAY PERFUSION ASSISTED LIQUID VENTILATOR
    James Parker; Fiscal Year: 2002
    ..Other applications include continuous intrapulmonary administration of drugs and anesthetics and clearance of material from the lungs...
  46. SERPIN-PROTEASE REACTION, HYDRATION AND GEOMETRY CHANGES
    Maria McGee; Fiscal Year: 2002
    ..This information will serve to develop therapies to prevent and control thromboembolic complications of cardiovascular disease. ..
  47. OVINE INTERFERON-TAU REGULATES UTERINE HORMONE RECEPTOR
    Fuller Bazer; Fiscal Year: 2005
    ....
  48. ZOONOTIC AND XENOZOONOTIC RISKS OF HEPATITIS E VIRUS
    Xiang Jin Meng; Fiscal Year: 2001
    ..abstract_text> ..
  49. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
    ....
  50. Regulation of Fibroblast Survival in the Collagen Matrix
    Mark Carlson; Fiscal Year: 2005
    ..Loss of matrix anchorage is hypothesized to reverse these effects and induce apoptosis. The involvement of each protein will be probed with mutated isoforms. ..
  51. Selectins and Fetal wound Healing
    Oluyinka Olutoye; Fiscal Year: 2007
    ..These may then provide opportunities to assist with the inflammatory responses in these children when they are most vulnerable. ..
  52. Effects of Myostatin Deficiency on Bone Strength
    Mark Hamrick; Fiscal Year: 2007
    ..abstract_text> ..
  53. A Novel Mechanism for Intra-articular Nonunion
    Martha M Murray; Fiscal Year: 2010
    ....
  54. Molecular Surgeon Symposium on Genetics and Genomics of Pancreatic Cancer
    Changyi Chen; Fiscal Year: 2008
    ..Furthermore, invited speakers are encouraged to submit manuscripts related to their presentations to "World Journal of Surgery" for consideration of publications. [unreadable] [unreadable] [unreadable]..
  55. PRESERVATION OF LIVER SLICES BY VITRIFICATION
    Michael Taylor; Fiscal Year: 2005
    ..The molecular ice control formulations which provide the highest tissue viability and least interstitial ice formation will be tested in larger animal and human PCLS tissues in a sub-sequent Phase II SBIR proposal. ..
  56. ANGIOTENSIN II AND REGULATION OF MCP-1 GENE EXPRESSION
    Changyi Chen; Fiscal Year: 2002
    ....
  57. Pancreas Transporter Development and Validation
    Michael Taylor; Fiscal Year: 2006
    ..This research program is supported by collaboration with three major clinical centers interested in validation of this perfusion technology for their future use. [unreadable] [unreadable]..
  58. MOLECULAR ICE CONTROL FOR ENGINEERED TISSUES
    Michael Taylor; Fiscal Year: 2003
    ..The potential markets are enormous. Cryopreservation methods, which result in retained viability and function, will be licensed to the tissue engineering industry. ..
  59. Cerebral Microvascular Endothelin Production
    Momoh Yakubu; Fiscal Year: 2003
    ..Our understanding of the mechanisms underlying the consequences of SAH will make it possible for early and appropriate intervention to prevent or reduce these complications from hemorrhagic stroke. ..
  60. Effects of HAART drugs on endothelial dysfunction of pu*
    Changyi Chen; Fiscal Year: 2009
    ..abstract_text> ..
  61. HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTION
    Changyi Chen; Fiscal Year: 2004
    ..Together, the integrated basic science, non-human primate and human investigations offer a multi disciplinary approach to the understanding and prevention of protease inhibitor-associated vascular complications. ..
  62. Transcription Factors in Trophectoderm Differentiation
    Robert Roberts; Fiscal Year: 2007
    ..The studies are expected to reveal mechanisms underpinning the transition of embryonic stem cells to trophectoderm, a developmental event that immediately precedes implantation and a time when expression of hCG begins. ..
  63. Molecular Surgeon Symposium on Vascular Injury, Repair
    Changyi Chen; Fiscal Year: 2005
    ..A pre-approved letter for acceptance of submission of this application from NIH/NHLBI is included. ..
  64. Tissue engineering of small diameter vascular graft
    Changyi Chen; Fiscal Year: 2006
    ..Success of this proposal will directly indicate the clinical applications of tissue engineered small diameter vascular grafts. ..
  65. Effects of HIV Protease Inhibitors of Endothelial Barrie
    Changyi Chen; Fiscal Year: 2005
    ..Our findings may also suggest new therapeutic strategies, which may eventually prove effective for the prevention and treatment of these complications. ..
  66. Induced hypothermic arrest in traumatic shock
    Hasan Alam; Fiscal Year: 2005
    ..Sub aim 2: Develop and test methods and techniques that can facilitate the induction of hypothermic arrest in the setting of traumatic shock. ..
  67. VSV RNA TRANSCRIPTION AND REPLICATION
    ASIT PATTNAIK; Fiscal Year: 2005
    ..These studies are of major importance for an understanding of the mechanisms of the viral gene expression and virus growth. ..