swine

Summary

Summary: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).

Top Publications

  1. pmc Design of a high density SNP genotyping assay in the pig using SNPs identified and characterized by next generation sequencing technology
    Antonio M Ramos
    Wageningen University, Animal Breeding and Genomics Centre, Wageningen, The Netherlands
    PLoS ONE 4:e6524. 2009
  2. ncbi Mystery swine disease in The Netherlands: the isolation of Lelystad virus
    G Wensvoort
    Central Veterinary Institute, Virology Department, Lelystad, The Netherlands
    Vet Q 13:121-30. 1991
  3. ncbi Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States
    Eric J Neumann
    Office of Swine Health Information and Research, National Pork Board, 1776 NW 114th St, Clive, IA 50325, USA
    J Am Vet Med Assoc 227:385-92. 2005
  4. pmc Genome-wide association study identifies Loci for body composition and structural soundness traits in pigs
    Bin Fan
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa, United States of America
    PLoS ONE 6:e14726. 2011
  5. pmc Methicillin-resistant Staphylococcus aureus in pig farming
    Andreas Voss
    Radboud University Medical Centre, Nijmegen, The Netherlands
    Emerg Infect Dis 11:1965-6. 2005
  6. ncbi A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
    Anne Sophie Van Laere
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala University, BMC, Box 597, SE 751 24 Uppsala, Sweden
    Nature 425:832-6. 2003
  7. pmc Past, present, and future of Japanese encephalitis
    Tobias E Erlanger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Emerg Infect Dis 15:1-7. 2009
  8. pmc Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark
    Kegong Tian
    China Animal Disease Control Center, Beijing, China
    PLoS ONE 2:e526. 2007
  9. pmc Emergence and pandemic potential of swine-origin H1N1 influenza virus
    Gabriele Neumann
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
    Nature 459:931-9. 2009
  10. ncbi Swine as models in biomedical research and toxicology testing
    M M Swindle
    Medical University of South Carolina, Department of Comparative Medicine, MSC 777, 114 Doughty St, Charleston, SC 29425 7770, USA
    Vet Pathol 49:344-56. 2012

Detail Information

Publications306 found, 100 shown here

  1. pmc Design of a high density SNP genotyping assay in the pig using SNPs identified and characterized by next generation sequencing technology
    Antonio M Ramos
    Wageningen University, Animal Breeding and Genomics Centre, Wageningen, The Netherlands
    PLoS ONE 4:e6524. 2009
    ....
  2. ncbi Mystery swine disease in The Netherlands: the isolation of Lelystad virus
    G Wensvoort
    Central Veterinary Institute, Virology Department, Lelystad, The Netherlands
    Vet Q 13:121-30. 1991
    In early 1991, the Dutch pig-industry was struck by the so-called mystery swine disease. Large-scale laboratory investigations were undertaken to search for the etiological agent...
  3. ncbi Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States
    Eric J Neumann
    Office of Swine Health Information and Research, National Pork Board, 1776 NW 114th St, Clive, IA 50325, USA
    J Am Vet Med Assoc 227:385-92. 2005
    To estimate the annual cost of infections attributable to porcine reproductive and respiratory syndrome (PRRS) virus to US swine producers.
  4. pmc Genome-wide association study identifies Loci for body composition and structural soundness traits in pigs
    Bin Fan
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa, United States of America
    PLoS ONE 6:e14726. 2011
    The recent completion of the swine genome sequencing project and development of a high density porcine SNP array has made genome-wide association (GWA) studies feasible in pigs.
  5. pmc Methicillin-resistant Staphylococcus aureus in pig farming
    Andreas Voss
    Radboud University Medical Centre, Nijmegen, The Netherlands
    Emerg Infect Dis 11:1965-6. 2005
    ..While spa-type t108 is apparently a more widespread clone among pig farmers and their environment, we did find other spa-types...
  6. ncbi A regulatory mutation in IGF2 causes a major QTL effect on muscle growth in the pig
    Anne Sophie Van Laere
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala University, BMC, Box 597, SE 751 24 Uppsala, Sweden
    Nature 425:832-6. 2003
    ..The result supports the long-held view that regulatory mutations are important for controlling phenotypic variation...
  7. pmc Past, present, and future of Japanese encephalitis
    Tobias E Erlanger
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Emerg Infect Dis 15:1-7. 2009
    ..On a global scale, however, the incidence of JE may decline as a result of large-scale vaccination programs implemented in China and India...
  8. pmc Emergence of fatal PRRSV variants: unparalleled outbreaks of atypical PRRS in China and molecular dissection of the unique hallmark
    Kegong Tian
    China Animal Disease Control Center, Beijing, China
    PLoS ONE 2:e526. 2007
    ....
  9. pmc Emergence and pandemic potential of swine-origin H1N1 influenza virus
    Gabriele Neumann
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin 53711, USA
    Nature 459:931-9. 2009
    ..A prime example is the recent emergence of swine-origin H1N1 viruses that have transmitted to and spread among humans, resulting in outbreaks internationally...
  10. ncbi Swine as models in biomedical research and toxicology testing
    M M Swindle
    Medical University of South Carolina, Department of Comparative Medicine, MSC 777, 114 Doughty St, Charleston, SC 29425 7770, USA
    Vet Pathol 49:344-56. 2012
    b>Swine are considered to be one of the major animal species used in translational research, surgical models, and procedural training and are increasingly being used as an alternative to the dog or monkey as the choice of nonrodent species ..
  11. pmc Diverse and abundant antibiotic resistance genes in Chinese swine farms
    Yong Guan Zhu
    Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China
    Proc Natl Acad Sci U S A 110:3435-40. 2013
    ..at three stages of manure processing to land disposal at three large-scale (10,000 animals per year) commercial swine farms in China...
  12. ncbi Virulence factors involved in the pathogenesis of the infection caused by the swine pathogen and zoonotic agent Streptococcus suis
    Nahuel Fittipaldi
    Groupe de Recherche sur les Maladies Infectieuses du Porc and Centre de Recherche en Infectiologie Porcine, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 rue Sicotte, CP5000, St Hyacinthe, Quebec, J2S 7C6, Canada
    Future Microbiol 7:259-79. 2012
    Streptococcus suis is a major swine pathogen responsible for important economic losses to the swine industry worldwide. It is also an emerging zoonotic agent of meningitis and streptococcal toxic shock-like syndrome...
  13. pmc Classical swine fever virus N(pro) limits type I interferon induction in plasmacytoid dendritic cells by interacting with interferon regulatory factor 7
    Ana R Fiebach
    Institute of Virology and Immunoprophylaxis IVI, Mittelhausern, Switzerland
    J Virol 85:8002-11. 2011
    ..Here, we report that N(pro) of classical swine fever virus (CSFV) interacts also with IRF7, another mediator of type I IFN induction...
  14. ncbi Comparative analyses of the complete mitochondrial genomes of Ascaris lumbricoides and Ascaris suum from humans and pigs
    Guo hua Liu
    State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, PR China
    Gene 492:110-6. 2012
    ..lumbricoides and A. suum may represent the same species. The mt genome data presented in this study are also useful novel markers for studying the molecular epidemiology and population genetics of Ascaris...
  15. pmc Are Ascaris lumbricoides and Ascaris suum a single species?
    Daniela Leles
    Departamento de Microbiologia e Parasitologia, Instituto Biomedico, Universidade Federal Fluminense, MIP UFF, Rua Professor Hernani Melo 101, São Domingos, Niteroi, 24210 130, RJ, Brazil
    Parasit Vectors 5:42. 2012
    ..Finally, we conclude that Ascaris lumbricoides and A. suum are a single species and that the name A. lumbricoides Linnaeus 1758 has taxonomic priority; therefore A. suum Goeze 1782 should be considered a synonym of A. lumbricoides...
  16. pmc Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals
    M Matrosovich
    Department of Virology and Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, Russia
    J Virol 74:8502-12. 2000
    ..we studied the HAs of the initial isolates from the human pandemics of 1957 (H2N2) and 1968 (H3N2), the European swine epizootic of 1979 (H1N1), and the seal epizootic of 1992 (H3N3), all of which were caused by the introduction of ..
  17. ncbi Immunological solutions for treatment and prevention of porcine reproductive and respiratory syndrome (PRRS)
    Michael P Murtaugh
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN, USA
    Vaccine 29:8192-204. 2011
    ..Despite these impediments, we should be confident that progress will be made. Sequencing of the swine genome is providing a rich source of primary knowledge of gene structure and transcriptional regulation that is ..
  18. pmc Estimation of linkage disequilibrium in four US pig breeds
    Yvonne M Badke
    Department of Animal Science, Michigan State University, East Lansing, MI, USA
    BMC Genomics 13:24. 2012
    ..To implement marker assisted selection in the swine breeding industry, information about extent and degree of LD is essential...
  19. pmc Advances in swine biomedical model genomics
    Joan K Lunney
    APDL, BARC, ARS, United States Department of Agriculture, Beltsville, MD 20705, USA
    Int J Biol Sci 3:179-84. 2007
    This review is a short update on the diversity of swine biomedical models and the importance of genomics in their continued development...
  20. pmc Genome-wide footprints of pig domestication and selection revealed through massive parallel sequencing of pooled DNA
    Andreia J Amaral
    Animal Breeding and Genomics Centre, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 6:e14782. 2011
    ..Artificial selection has caused rapid evolution in domesticated species. The identification of selection footprints across domesticated genomes can contribute to uncover the genetic basis of phenotypic diversity...
  21. pmc Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans
    Rebecca J Garten
    WHO Collaborating Center for Influenza, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Science 325:197-201. 2009
    ..2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans...
  22. pmc Comparison of molecular and biological characteristics of a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (ingelvac PRRS MLV), the parent strain of the vaccine (ATCC VR2332), ATCC VR2385, and two recent field isolates o
    T Opriessnig
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
    J Virol 76:11837-44. 2002
    ..Our data strongly suggest that isolate 98-38803 is a derivative of Ingelvac PRRS MLV and that the isolate is pneumovirulent...
  23. pmc Environmental injustice in North Carolina's hog industry
    S Wing
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7400, USA
    Environ Health Perspect 108:225-31. 2000
    ....
  24. pmc Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics
    Y Kawaoka
    Department of Virology Molecular Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38101 0318
    J Virol 63:4603-8. 1989
    ..Comparative analysis of deduced amino acid sequences disclosed highly conserved regions in PB1 proteins, which may be key structures required for PB1 activities...
  25. ncbi Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic
    Gavin J D Smith
    State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Nature 459:1122-5. 2009
    In March and early April 2009, a new swine-origin influenza A (H1N1) virus (S-OIV) emerged in Mexico and the United States...
  26. pmc In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
    Yasushi Itoh
    Department of Pathology, Shiga University of Medical Science, Ohtsu, Shiga 520 2192, Japan
    Nature 460:1021-5. 2009
    ..as an influenza A virus of the H1N1 subtype, the genomic segments of the new strain were most closely related to swine viruses...
  27. ncbi Livestock-associated methicillin-resistant Staphylococcus aureus in animals and humans
    Haitske Graveland
    Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, P O Box 80 176, 3508 TD Utrecht, The Netherlands
    Int J Med Microbiol 301:630-4. 2011
    ..Ongoing MRSA surveillance in humans and animals is needed to detect changes in epidemiology and to implement effective control measures...
  28. pmc Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets
    Melissa B Pearce
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 109:3944-9. 2012
    Recent isolation of a novel swine-origin influenza A H3N2 variant virus [A(H3N2)v] from humans in the United States has raised concern over the pandemic potential of these viruses...
  29. pmc Methicillin-resistant Staphylococcus aureus (MRSA) strain ST398 is present in midwestern U.S. swine and swine workers
    Tara C Smith
    Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA
    PLoS ONE 4:e4258. 2009
    Recent research has demonstrated that many swine and swine farmers in the Netherlands and Canada are colonized with MRSA...
  30. pmc Comparative fecal metagenomics unveils unique functional capacity of the swine gut
    Regina Lamendella
    National Risk Management Research Laboratory, U S Environmental Protection Agency, Cincinnati, OH 45268, USA
    BMC Microbiol 11:103. 2011
    Uncovering the taxonomic composition and functional capacity within the swine gut microbial consortia is of great importance to animal physiology and health as well as to food and water safety due to the presence of human pathogens in ..
  31. ncbi Nipah virus: a recently emergent deadly paramyxovirus
    K B Chua
    Department of Medical Microbiology, University of Malaya Medical Center, 50603 Kuala Lumpur, Malaysia
    Science 288:1432-5. 2000
    ..Like Hendra virus, Nipah virus is unusual among the paramyxoviruses in its ability to infect and cause potentially fatal disease in a number of host species, including humans...
  32. ncbi Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine
    Peter Schierack
    Institut für Mikrobiologie und Tierseuchen, Freie Universitat Berlin, Berlin, Germany
    Histochem Cell Biol 125:293-305. 2006
    In vitro studies on the pathogenesis in swine have been hampered by the lack of relevant porcine cell lines...
  33. pmc An atlas of DNA methylomes in porcine adipose and muscle tissues
    Mingzhou Li
    Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya an, Sichuan 625014, China
    Nat Commun 3:850. 2012
    ..This comprehensive map provides a solid basis for exploring epigenetic mechanisms of adipose deposition and muscle growth...
  34. pmc Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses
    Craig R Johnson
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    J Gen Virol 92:1107-16. 2011
    ..as the causative agent of porcine reproductive and respiratory syndrome (PRRS), now the most important disease of swine worldwide...
  35. ncbi Pig liver sausage as a source of hepatitis E virus transmission to humans
    Philippe Colson
    Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie Hygiène Virologie, Centre Hospitalo Universitaire Timone, Marseille, France
    J Infect Dis 202:825-34. 2010
    ..We investigated the role of figatellu, a traditional pig liver sausage widely eaten in France and commonly consumed raw, as a source of HEV infection...
  36. pmc MicroRNAome of porcine pre- and postnatal development
    Mingzhou Li
    Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya an, Sichuan, China
    PLoS ONE 5:e11541. 2010
    ..These results are prelude to the advancement in pig biology as well the use of pigs as model organism for human biological and biomedical studies...
  37. ncbi Spa type distribution in Staphylococcus aureus originating from pigs, cattle and poultry
    H Hasman
    Technical University of Denmark, National Food Institute, Bulowsvej 27, 1790 Copenhagen V, Denmark
    Vet Microbiol 141:326-31. 2010
    ..In conclusion, strains of MSSA CC398 were commonly present in pigs but not present at all in the other reservoirs tested...
  38. pmc Adaptive strategies of the influenza virus polymerase for replication in humans
    Andrew Mehle
    Departments of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, CA 94705, USA
    Proc Natl Acad Sci U S A 106:21312-6. 2009
    ..A 2009 swine-origin H1N1 influenza A virus recently established a pandemic infection in humans, even though the virus encodes a ..
  39. ncbi The development of porcine models of obesity and the metabolic syndrome
    Michael E Spurlock
    Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA
    J Nutr 138:397-402. 2008
    ....
  40. pmc Discovery of porcine microRNAs in multiple tissues by a Solexa deep sequencing approach
    Sheng Song Xie
    Key Lab of Agricultural Animal Genetics, Breeding, and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture, Huazhong Agricultural University, Wuhan, People s Republic of China
    PLoS ONE 6:e16235. 2011
    ..Taken together, our results add new information to existing data on porcine miRNAs and should be useful for investigating the biological functions of miRNAs in pig and other species...
  41. pmc In-feed antibiotic effects on the swine intestinal microbiome
    Torey Looft
    Agricultural Research Service, National Animal Disease Center, US Department of Agriculture, Ames, IA 50010, USA
    Proc Natl Acad Sci U S A 109:1691-6. 2012
    ..used phylogenetic, metagenomic, and quantitative PCR-based approaches to address the impact of antibiotics on the swine gut microbiota...
  42. pmc A genome-wide association study on androstenone levels in pigs reveals a cluster of candidate genes on chromosome 6
    Naomi Duijvesteijn
    IPG, Institute for Pig Genetics B V, PO Box 43, 6640AA, Beuningen, The Netherlands
    BMC Genet 11:42. 2010
    ..The identification of major genetic effects causing boar taint would accelerate the reduction of boar taint through breeding to finally eliminate the need for castration...
  43. ncbi Emergence of Clostridium difficile infection due to a new hypervirulent strain, polymerase chain reaction ribotype 078
    Abraham Goorhuis
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    Clin Infect Dis 47:1162-70. 2008
    ..This strain has also been identified as the predominant strain in pigs and calves...
  44. pmc Reassortment of pandemic H1N1/2009 influenza A virus in swine
    D Vijaykrishna
    State Key Laboratory of Emerging Infectious Diseases and Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China
    Science 328:1529. 2010
    The emergence of pandemic H1N1/2009 influenza demonstrated that pandemic viruses could be generated in swine. Subsequent reintroduction of H1N1/2009 to swine has occurred in multiple countries...
  45. ncbi Genome-wide association studies for hematological traits in swine
    J Y Wang
    Key Laboratory of Animal Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science and Technology, China
    Anim Genet 44:34-43. 2013
    ..Thus far, few studies have been conducted using a high-density swine SNP chip panel to unravel the genetic mechanism of the immune capability in domestic animals...
  46. pmc Large scale genome-wide association and LDLA mapping study identifies QTLs for boar taint and related sex steroids
    Eli Grindflek
    NORSVIN The Norwegian Pig Breeders Association, 2304 Hamar, Norway
    BMC Genomics 12:362. 2011
    ....
  47. pmc Nasal colonization of humans with methicillin-resistant Staphylococcus aureus (MRSA) CC398 with and without exposure to pigs
    Christiane Cuny
    Robert Koch Institute, Wernigerode Branc, Wernigerode, Germany
    PLoS ONE 4:e6800. 2009
    ..The study presented here addresses the question of further transmission to non exposed humans...
  48. pmc Global transmission of influenza viruses from humans to swine
    Martha I Nelson
    Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA
    J Gen Virol 93:2195-203. 2012
    To determine the extent to which influenza viruses jump between human and swine hosts, we undertook a large-scale phylogenetic analysis of pandemic A/H1N1/09 (H1N1pdm09) influenza virus genome sequence data...
  49. pmc Pathogenesis of pandemic influenza A (H1N1) and triple-reassortant swine influenza A (H1) viruses in mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 84:4194-203. 2010
    ..relative virulence of selected 2009 H1N1 viruses and compared them to a representative human triple-reassortant swine influenza virus that has circulated in pigs in the United States for over a decade preceding the current pandemic...
  50. ncbi Cytokine profiles induced by the novel swine-origin influenza A/H1N1 virus: implications for treatment strategies
    Patrick C Y Woo
    State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China
    J Infect Dis 201:346-53. 2010
    BACKGROUND. Given the apparent high mortality associated with the novel swine-origin influenza A/H1N1 virus (S-OIV) in Mexico, we aimed to study the cytokine profiles induced by S-OIV and the effect of immunomodulators. METHODS...
  51. pmc Cocirculation of avian H9N2 and contemporary "human" H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment?
    J S Peiris
    Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, People s Republic of China
    J Virol 75:9679-86. 2001
    ..Cocirculation of avian H9N2 and human H3N2 viruses in pigs provides an opportunity for genetic reassortment leading to the emergence of viruses with pandemic potential...
  52. pmc Livestock-associated methicillin-resistant Staphylococcus aureus in humans, Europe
    Brigitte A G L van Cleef
    Epidemiology and Surveillance Unit, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Emerg Infect Dis 17:502-5. 2011
    ..Livestock-associated MRSA ST398 accounted for only a small proportion of MRSA isolates from humans; most were from the Netherlands, Belgium, Denmark, and Austria...
  53. ncbi Infection and colonization with methicillin resistant Staphylococcus aureus ST398 versus other MRSA in an area with a high density of pig farms
    M W H Wulf
    PAMM Laboratory for Medical Microbiology, de Run 6250, Veldhoven, The Netherlands
    Eur J Clin Microbiol Infect Dis 31:61-5. 2012
    ..ST398 isolates were more often multi-resistant than isolates of other spa-types. The emergence of MRSA ST398 led to an increase in both MRSA carriers and MRSA infections...
  54. ncbi Domestic-animal genomics: deciphering the genetics of complex traits
    Leif Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE 751 24 Uppsala, Sweden
    Nat Rev Genet 5:202-12. 2004
  55. ncbi Methicillin resistant Staphylococcus aureus colonization in pigs and pig farmers
    T Khanna
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Vet Microbiol 128:298-303. 2008
    ..This study demonstrates that MRSA is common in pigs in Ontario, Canada, and provides further support to concerns about transmission of MRSA between pigs and humans...
  56. pmc Single-reaction genomic amplification accelerates sequencing and vaccine production for classical and Swine origin human influenza a viruses
    Bin Zhou
    Wadsworth Center, New York State Department of Health, Albany, New York 12201, USA
    J Virol 83:10309-13. 2009
    ..We used these procedures to rescue a contemporary H3N2 virus and a swine origin H1N1 virus directly from human swab specimens...
  57. ncbi Inhibition of porcine reproductive and respiratory syndrome virus by interferon-gamma and recovery of virus replication with 2-aminopurine
    R R Rowland
    Department of Biology-Microbiology, South Dakota State University, Brookings, South Dakota, USA
    Arch Virol 146:539-55. 2001
    ..Immunostaining with anti-PKR antibody showed a redistribution of PKR from the cytoplasm into nucleoli of infected cells...
  58. pmc Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 325:484-7. 2009
    Recent reports of mild to severe influenza-like illness in humans caused by a novel swine-origin 2009 A(H1N1) influenza virus underscore the need to better understand the pathogenesis and transmission of these viruses in mammals...
  59. ncbi Streptococcus suis: an emerging human pathogen
    Heiman F L Wertheim
    Oxford University Clinical Research Unit, National Institute of Infectious and Tropical Diseases, Hanoi, Vietnam
    Clin Infect Dis 48:617-25. 2009
    ..Meningitis and sepsis are the most common clinical manifestations of S. suis infection; hearing loss is a frequent complication. In this article, we provide an overview of the emergence and clinical manifestations of S. suis infection...
  60. ncbi Preventing heart injury during negative pressure wound therapy in cardiac surgery: assessment using real-time magnetic resonance imaging
    Malin Malmsjo
    Department of Medicine, Lund University Hospital, Lund, Sweden
    J Thorac Cardiovasc Surg 138:712-7. 2009
    ..The present study aimed to examine the effects of negative pressure wound therapy on the position of the heart in relation to the thoracic wall using magnetic resonance imaging in a porcine sternotomy wound model...
  61. ncbi Role of neutralizing antibodies in PRRSV protective immunity
    O J Lopez
    Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, 141 VBS, East Campus, UNL, Lincoln, NE 68583 0905, USA
    Vet Immunol Immunopathol 102:155-63. 2004
    ..This information should prove central to the design of new generation vaccines against PRRSV...
  62. pmc Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity
    Henry C Quevedo
    Interdisciplinary Stem Cell Institute and Department of Medicine, Cardiovascular Division, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 106:14022-7. 2009
    ..Twelve weeks after myocardial infarction, female swine received catheter-based transendocardial injections of either placebo (n = 4) or male allogeneic MSCs (200 million;..
  63. pmc Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs
    Christopher S Rogers
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Science 321:1837-41. 2008
    ..The pig model may provide opportunities to address persistent questions about CF pathogenesis and accelerate discovery of strategies for prevention and treatment...
  64. ncbi The emergence of Staphylococcus aureus ST398
    Tara C Smith
    Department of Epidemiology, Center for Emerging Infectious Diseases, University of Iowa, Iowa City, IA 52242, USA
    Vector Borne Zoonotic Dis 11:327-39. 2011
    ..More recently, a third group of MRSA strains have been identified in association with livestock, particularly swine. These strains, termed livestock-associated MRSA, have now been identified in Europe, North America, and Asia in ..
  65. ncbi Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning
    Liangxue Lai
    Department of Animal Science, University of Missouri, Columbia, MO 65211, USA
    Science 295:1089-92. 2002
    ..These pigs were produced by nuclear transfer technology; clonal fetal fibroblast cell lines were used as nuclear donors for embryos reconstructed with enucleated pig oocytes...
  66. ncbi Successful piglet production after transfer of blastocysts produced by a modified in vitro system
    Kazuhiro Kikuchi
    Genetic Diversity Department, National Institute of Agrobiological Sciences, Kannondai 2 1 2, Tsukuba, Ibaraki 305 8602, Japan
    Biol Reprod 66:1033-41. 2002
    ..This system has advantages for the generation of cloned and transgenic pigs...
  67. ncbi Monoclonal antibodies isolated from human B cells neutralize a broad range of H1 subtype influenza A viruses including swine-origin Influenza virus (S-OIV)
    Roberto Burioni
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy
    Virology 399:144-52. 2010
    The new H1N1 swine-origin influenza virus (S-OIV) strain is a global health problem. The elucidation of the virus-host relationship is crucial for the control of the new infection...
  68. ncbi North American and European porcine reproductive and respiratory syndrome viruses differ in non-structural protein coding regions
    R Allende
    Department of Veterinary and Biomedical Sciences, University of Nebraska Lincoln, 68583 0905, USA
    J Gen Virol 80:307-15. 1999
    ..The 3' NCR (150 nucleotides) was 76% identical between isolates. These genomic differences confirm the presence of distinct North American and European PRRSV genotypes...
  69. pmc Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals
    Debby van Riel
    Department of Virology, Erasmus MC, P O Box 2040, 3015 CA, Rotterdam, The Netherlands
    Am J Pathol 171:1215-23. 2007
    ..The PVA in human respiratory tract most closely mirrored that in ferrets and pigs for human influenza viruses and that in ferrets, pigs, and cats for avian influenza viruses...
  70. pmc Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing
    Shuqi Xiao
    State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou, Guangdong, China
    PLoS ONE 5:e11377. 2010
    ..reproductive and respiratory syndrome (PRRS) has been one of the most economically important diseases affecting swine industry worldwide and causes great economic losses each year...
  71. pmc A glimpse of streptococcal toxic shock syndrome from comparative genomics of S. suis 2 Chinese isolates
    Chen Chen
    Beijing Genomics Institute, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 2:e315. 2007
    ..However, the molecular mechanisms underlying STSS are poorly understood...
  72. ncbi Porcine circovirus diseases
    Joaquim Segales
    Virology Department, Veterinary Research Laboratory, Veterinary Sciences Division, Stoney Road Stormont, DARDNI, Stormont, BT4 SD Belfast, Northern Ireland, UK
    Anim Health Res Rev 6:119-42. 2005
    ..Among them, only PMWS is considered to have a severe impact on domestic swine production...
  73. pmc MicroRNA transcriptome profiles during swine skeletal muscle development
    Tara G McDaneld
    USDA ARS Meat Animal Research Center, Clay Center, NE, USA
    BMC Genomics 10:77. 2009
    ..To evaluate the role of miR in skeletal muscle of swine, global microRNA abundance was measured at specific developmental stages including proliferating satellite cells, ..
  74. pmc Completion of the swine genome will simplify the production of swine as a large animal biomedical model
    Eric M Walters
    National Swine Resource and Research Center, University of Missouri, Columbia, MO 65211, USA
    BMC Med Genomics 5:55. 2012
    Anatomic and physiological similarities to the human make swine an excellent large animal model for human health and disease.
  75. pmc Ancient DNA, pig domestication, and the spread of the Neolithic into Europe
    Greger Larson
    Department of Zoology, Henry Wellcome Ancient Biomolecules Centre, South Parks Road, Oxford OX1 3PS, United Kingdom
    Proc Natl Acad Sci U S A 104:15276-81. 2007
    ..Domestic pigs formed a key component of the Neolithic Revolution, and this detailed genetic record of their origins reveals a complex set of interactions and processes during the spread of early farmers into Europe...
  76. pmc Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury
    Javier A Sala-Mercado
    Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Circulation 122:S179-84. 2010
    ..Our aim was to test this paradigm in a clinically relevant, large animal model of acute myocardial infarction...
  77. pmc Structural and functional annotation of the porcine immunome
    Harry D Dawson
    USDA ARS, Beltsville Human Nutrition Research Center, Diet, Genomics, Immunology Laboratory, Beltsville, MD 20705, USA
    BMC Genomics 14:332. 2013
    ..Susceptibility to infectious disease is one of the major constraints on swine performance, yet the structure and function of genes comprising the pig immunome are not well-characterized...
  78. pmc Evolution of novel reassortant A/H3N2 influenza viruses in North American swine and humans, 2009-2011
    Martha I Nelson
    Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 86:8872-8. 2012
    Novel H3N2 influenza viruses (H3N2v) containing seven genome segments from swine lineage triple-reassortant H3N2 viruses and a 2009 pandemic H1N1 (H1N1pdm09) matrix protein segment (pM) were isolated from 12 humans in the United States ..
  79. ncbi Challenges for porcine reproductive and respiratory syndrome virus (PRRSV) vaccinology
    Tjeerd G Kimman
    Central Veterinary Institute of Wageningen UR CVI, P O Box 65, 8200 AB Lelystad, The Netherlands
    Vaccine 27:3704-18. 2009
    ....
  80. pmc Prevalence of livestock-associated MRSA in communities with high pig-densities in The Netherlands
    Brigitte A van Cleef
    Centre for Infectious Disease Control Netherlands, RIVM National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    PLoS ONE 5:e9385. 2010
    ..This cross-sectional study aimed to determine the spread to persons not in direct contact with livestock in areas with a high density of pig farms...
  81. pmc Spatial dynamics of human-origin H1 influenza A virus in North American swine
    Martha I Nelson
    Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 7:e1002077. 2011
    The emergence and rapid global spread of the swine-origin H1N1/09 pandemic influenza A virus in humans underscores the importance of swine populations as reservoirs for genetically diverse influenza viruses with the potential to infect ..
  82. pmc Human Streptococcus suis outbreak, Sichuan, China
    Hongjie Yu
    Chinese Center for Disease Control and Prevention, Beijing, People s Republic of China
    Emerg Infect Dis 12:914-20. 2006
    ..A single strain of S. suis caused the outbreak, as shown by the identification of a single ribotype. The high death ratio was of concern; prohibiting backyard slaughtering ended the outbreak...
  83. ncbi Diabetes-induced accelerated atherosclerosis in swine
    R G Gerrity
    Department of Pathology, Medical College of Georgia, 1120 15th St, Augusta, GA 30912, USA
    Diabetes 50:1654-65. 2001
    ..In this study, diabetes was superimposed on a well-characterized swine model of atherosclerosis by injection of the beta-cell cytotoxin streptozotocin (STZ), resulting in a >80% ..
  84. ncbi Streptococcus suis infections in humans: the Chinese experience and the situation in North America
    Marcelo Gottschalk
    Centre de Recherche en Infectiologie Porcine CRIP, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 rue Sicotte, St Hyacinthe, Quebec, J2S 2M2, Canada
    Anim Health Res Rev 8:29-45. 2007
    Infections caused by Streptococcus suis are considered a global problem in the swine industry. In this animal species, S. suis is associated with septicemia, meningitis, endocarditis, arthritis and, occasionally, other infections...
  85. ncbi Replication, pathogenicity, shedding, and transmission of Zaire ebolavirus in pigs
    Gary P Kobinger
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
    J Infect Dis 204:200-8. 2011
    ..See the editorial commentary by Bausch, on pages 179-81.)..
  86. pmc Novel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: infectious potential for humans
    Huachen Zhu
    International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China
    J Virol 85:10432-9. 2011
    ..The prevalence and repeated introduction of the pdm/09 virus into pigs raises the possibility of generating novel swine influenza viruses with the potential to infect humans...
  87. pmc Muscle transcriptomic profiles in pigs with divergent phenotypes for fatness traits
    Angela Cánovas
    IRTA, Genetica i Millora Animal, 191 Av Alcalde Rovira Roure, 25198 Lleida, Spain
    BMC Genomics 11:372. 2010
    ....
  88. ncbi Limited and excess dietary protein during gestation affects growth and compositional traits in gilts and impairs offspring fetal growth
    C Rehfeldt
    Leibniz Institute for Farm Animal Biology, 18196 Dummerstorf, Germany
    J Anim Sci 89:329-41. 2011
    ....
  89. pmc Integrating expression profiling and whole-genome association for dissection of fat traits in a porcine model
    S Ponsuksili
    Functional Genome Analysis Research Group, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
    J Lipid Res 52:668-78. 2011
    ..In this study, genome-wide association analysis of trait-correlated expression was successfully used in a porcine model to display molecular networks and list genes relevant to fatness traits...
  90. pmc Persistence of livestock-associated methicillin-resistant Staphylococcus aureus in field workers after short-term occupational exposure to pigs and veal calves
    Brigitte A G L van Cleef
    Centre for Infectious Disease Control Netherlands, RIVM National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 49:1030-3. 2011
    ..In conclusion, MRSA is frequently present after short-term occupational exposure, but in most cases the strain is lost again after 24 h...
  91. pmc Genome-wide association scan and phased haplotype construction for quantitative trait loci affecting boar taint in three pig breeds
    Vivi R Gregersen
    Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University, P, O, Box 50, DK 8830 Tjele, Denmark
    BMC Genomics 13:22. 2012
    ..In the study presented in this paper, markers and haplotypes, which can be applied to DNA-based selection schemes in order to reduce or eliminate the boar taint problem, are identified...
  92. pmc Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer
    Christopher S Rogers
    Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    J Clin Invest 118:1571-7. 2008
    ..In addition, because gene-modified mice often fail to replicate human diseases, this approach could be used to generate models of other human genetic diseases in species other than mice...
  93. ncbi Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-beta production by interfering with the RIG-I signaling pathway
    Rui Luo
    State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China
    Mol Immunol 45:2839-46. 2008
    Porcine reproductive and respiratory syndrome virus (PRRSV) is the cause of an economically important swine disease that has been devastating the swine industry since the late 1980s...
  94. pmc Vulnerability of polarised intestinal porcine epithelial cells to mycotoxin deoxynivalenol depends on the route of application
    Anne Kathrin Diesing
    Medical Faculty, Institute of Anatomy, Otto von Guericke University, Magdeburg, Germany
    PLoS ONE 6:e17472. 2011
    ..In the present study, the impact of the direction of DON exposure on epithelial cell behaviour and intestinal barrier integrity was elucidated...
  95. pmc Alveolar macrophages are indispensable for controlling influenza viruses in lungs of pigs
    Heui Man Kim
    Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, 220 Gung Dong, Yuseong Gu, Daejeon, 305 764, Korea
    J Virol 82:4265-74. 2008
    ..Taken together, our findings suggest that alveolar macrophages are essential for controlling H1N1 influenza viruses in pigs...
  96. ncbi Streptococcus suis: a new emerging or an old neglected zoonotic pathogen?
    Marcelo Gottschalk
    Streptococcus suis Research Laboratory and International Reference Laboratory for S suis Serotyping, Departement de Pathologie et Microbiologie, Universite de Montreal, CP 5000, St Hyacinthe, Quebec, Canada
    Future Microbiol 5:371-91. 2010
    Infections caused by Streptococcus suis are considered a global and an economical problem in the swine industry. Moreover, S. suis is an agent of zoonosis that afflicts people in close contact with infected pigs or pork-derived products...
  97. pmc Small rho GTPases and cholesterol biosynthetic pathway intermediates in African swine fever virus infection
    Jose I Quetglas
    Departamento de Biotecnologia Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, INIA, Madrid, Spain
    J Virol 86:1758-67. 2012
    The integrity of the cholesterol biosynthesis pathway is required for efficient African swine fever virus (ASFV) infection...
  98. ncbi Ebola Reston virus infection of pigs: clinical significance and transmission potential
    Glenn A Marsh
    Australian Animal Health Laboratory, Livestock Industries, Commonwealth Scientific and Industrial Research Organisation CSIRO, Geelong, Australia
    J Infect Dis 204:S804-9. 2011
    ..conducted experimental challenge studies in 5-week-old pigs, with exposure of animals to 10(6) TCID(50) of a 2008 swine isolate of REBOV via either the oronasal or subcutaneous route...
  99. pmc A combined long-range phasing and long haplotype imputation method to impute phase for SNP genotypes
    John M Hickey
    University of New England, Armidale, Australia
    Genet Sel Evol 43:12. 2011
    ..Long-range phasing and haplotype library imputation constitute a fast and accurate method to impute phase for SNP data...
  100. ncbi Apoptosis and porcine reproductive and respiratory syndrome virus
    Laura C Miller
    Roman L Hruska U S Meat Animal Research Center MARC, ARS, USDA, State Spur 18D, P O Box 166, Clay Center, NE 68933 0166, USA
    Vet Immunol Immunopathol 102:131-42. 2004
    ..This study indicates that PRRSV-infected MARC-145 cells undergo necrosis at a much higher level than apoptosis, and increases with virus levels used to infect the cells...
  101. ncbi Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets
    Vincent J Munster
    National Influenza Center and Department of Virology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
    Science 325:481-3. 2009
    The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments...

Research Grants80

  1. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..There are also a number of emerging viruses such as West Nile and the breaking Mexican swine flu, and a number of potential bioterrorism pathogens such as smallpox that are of concern to the safety of the ..
  2. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..amp;amp;control</keyword;keyword>*Stem Cell Transplantation</keyword;keyword>Swine</keyword;/keywords;dates;year>2000</year;pub-dates;date>Jun</date;/pub-dates;/dates;accession-num&..
  3. Transgenesis and Xenotransplantation
    Jorge A Piedrahita; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The ability to efficiently modify the swine genome to generate genetically modified animals has the potential to provide a novel source of cells/tissues for clinical applications...
  4. Investigation of Occupational Exposure to and Infection by MRSA in Rural Iowa
    Tara Smith; Fiscal Year: 2012
    ..As pilot studies by our group have documented the presence of MRSA in US swine, we seek to expand upon this research and examine the epidemiology of Staphylococcus aureus more broadly in ..
  5. Clinical Development of Hemostatic Agent ClotFoam for Severe Hemorrhage
    Maja Nowakowski; Fiscal Year: 2013
    ..S. Army) in the swine model, have established the remarkable sealing properties of the agent...
  6. Mechanisms of coronary microvascular dysfunction in metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2012
    ..The proposed studies will be performed on Ossabaw swine fed a normal maintenance diet (7% kcal from fat) or an atherogenic diet (45% kcal from fat and 2% cholesterol) for ..
  7. Vitamin A adjuvant to enhance gut immunity and rotavirus vaccines in neonates
    Linda J Saif; Fiscal Year: 2010
    ..Also swine metabolize retinol comparable to humans...
  8. CT Evaluation of the Myocardial Effects of Risk Factors
    Lilach O Lerman; Fiscal Year: 2013
    ..Importantly, however, novel imaging techniques for studying the myocardial microcirculation, and swine models that mimic human cardiovascular physiology and pathophysiology, now provide a unique opportunity to ..
  9. Ibis T-6,000 Biosensor System
    CYNTHIA SEARS; Fiscal Year: 2010
    ..Most recently, this system was used to diagnosis the first swine H1N1 2009 cases in the United States...
  10. Modulation of Natriuretic Peptides via Caveolin in Hypertrophy and Heart Failure.
    David M Roth; Fiscal Year: 2013
    ..determine if gene transfer of Cav-3 modulates ANP and shows efficacy in a preclinical model of heart failure in swine. State of the art molecular and physiological techniques will be used in the studies in clinically relevant models ..
  11. Surgical Revascularization's Impact on Mitochondria in Hibernating Myocardium
    ROSEMARY FRANCES KELLY; Fiscal Year: 2013
    ..Our group has successfully established a reproducible swine model of hibernating myocardium and has studied this model extensively...
  12. EPICARDIAL ADIPOSE TISSUE, OBESITY AND INFLAMMATION IN ATHEROSCLEROSIS
    Devendra K Agrawal; Fiscal Year: 2013
    ..Aim 3: Our hypothesis predicts that enhanced inflammatory phenotype of EAT in obese and atherosclerotic swine is due to increased translocation of NF-?B to the nucleus via increased transcription and translation of importin-[..
  13. Carbohydrate-based Antiinfective Agents
    Chi Huey Wong; Fiscal Year: 2013
    ..g., the rapid emergence of Tamiflu resistant "swine flu" during the 2009 level-6 pandemic outbreak) and antigenic drift (i.e., escape from protective immunity)...
  14. IRES-mediated translation initiation on viral mRNAs
    CHRISTOPHER ULRICH TRISTRAM HELLEN; Fiscal Year: 2013
    ..The IRES of classical swine fever virus, a pestivirus, is substantially resistant to inhibition by eIF2 phosphorylation, which can be ..
  15. Autologous EPC lining to improve biocompatibility of circulatory assist devices
    Jeffrey H Lawson; Fiscal Year: 2010
    ..the following specific aims: Specific Aim 1: to genetically enhance endothelial progenitor cells, isolated from swine peripheral blood, by over-expressing the anticoagulant and anti-inflammatory protein thrombomodulin (TM) before ..
  16. Crossprotective CTL Against Influenza
    Ellis L Reinherz; Fiscal Year: 2013
    ..Such alterations adversely impact public health preparedness. The current swine flu H1N1 pandemic 2009 strain is a case in point...
  17. Stem Cells For Myocardial Repair: A Large Bore Magnet Study
    Jianyi Zhang; Fiscal Year: 2012
    ..We have recently established a population of multipotent adult progenitor cells from swine bone marrow (sMPC) that can proliferate for >100 population doublings, and differentiate at the single cell ..
  18. Cardiovascular effects of GLP-1 in obesity/metabolic syndrome
    Johnathan D Tune; Fiscal Year: 2013
    ..first evidence for impaired myocardial GLP-1 responses in the setting of the obese-metabolic syndrome (MetS) in swine and type 2 diabetes mellitus in humans...
  19. Genetic Epidemiology of Life-Threatening Influenza in Children
    Adrienne G Randolph; Fiscal Year: 2013
    ..We are in the midst of an influenza pandemic caused by a novel H1N1 influenza strain that includes swine origin viral DNA...
  20. Stem Cell Based Therapy for Regenerative Endodontics
    George T J Huang; Fiscal Year: 2013
    ..Aim 3- To test pulp regeneration in a relevant tissue environment in swine. This experimental swine model simulates actual clinical applications in humans using autologous stem cells for ..
  21. CT imaging for the assessment of kidney injury distal to renal artery stenosis
    Lilach O Lerman; Fiscal Year: 2013
    ..To test this hypothesis we will utilize obese swine, a unique large animal model with a naturally occurring constellation of features of the MetS, and a combination ..
  22. Induced Pluripotent Stem Cells from Swine: application to genetic modification
    ROBERT MICHAEL ROBERTS; Fiscal Year: 2013
    ..Such chimeras may also be valuable as an alternative to cloning for creating genetically modified swine. Aim 2 is to determine whether or not the various LIF-and FGF2-dependent piPSC at our disposal are superior donors ..
  23. Mathematical Modeling of Inflammation in ARDS
    Gary F Nieman; Fiscal Year: 2010
    ..settings of acute inflammation, and have calibrated distinct variants of this model with data from mice, rats, swine, and humans (University of Pittsburgh Inflammatory Analyte/Modeling Component)...
  24. Mathematical Modeling of Inflammation in ARDS
    Yoram Vodovotz; Fiscal Year: 2010
    ..settings of acute inflammation, and have calibrated distinct variants of this model with data from mice, rats, swine, and humans (University of Pittsburgh Inflammatory Analyte/Modeling Component)...
  25. Point of care microfluidic diagnosis system for rapid and sensitive detection of
    Michel G Bergeron; Fiscal Year: 2013
    ..Seventeen viruses, including influenza A (such as avian flu and swine flu), influenza B, SARS coronavirus, parainfluenza, and adenovirus responsible for the majority of VRTI along with ..
  26. A Novel Therapy for Septic Shock
    Xiaoling Qiang; Fiscal Year: 2011
    ..pharmacokinetic properties of rhMFG-E8 in normal and septic animals;and 5) determine the efficacy of rhMFG-E8 in a swine model of septic shock...
  27. Barcoded Magnetic Beads for Rapid Tests of MRSA and Respiratory Viral Panels
    WINSTON Z HO; Fiscal Year: 2010
    ..The 2009 Influenza A/H1N1, or "swine flu," pandemic occupied the time and attention of many...
  28. Mechanisms of Immune Modulation by Probiotics
    Lijuan Yuan; Fiscal Year: 2012
    ..facilitates extrapolating our findings to humans and prevents interference and confounding factors from wild swine rotavirus contaminations...
  29. VITAMIN D AND IMMUNOMODULATION IN CORONARY ARTERY DISEASE
    Devendra K Agrawal; Fiscal Year: 2013
    ..effect of vitamin D status on the outcome measures of coronary patency following intervention in a well-controlled swine model of atherosclerosis and to determine the underlying cellular and molecular mechanisms...
  30. Construct novel influenza A (H1N1) virus chimeric HA genes for development of bro
    VICTOR CHESTER HUBER; Fiscal Year: 2010
    ..The recent emergence and pandemic classification of novel swine-origin influenza A H1N1 virus, 2009 A (H1N1) poses a significant threat to public health...
  31. Susceptibility and Protective Immunity to Noroviruses
    Ralph S Baric; Fiscal Year: 2013
    ..4 challenge model in swine and characterizes human monoclonal antibodies (mAb) to GI and GII strains, providing key reagents for advancing ..
  32. Nuclear magnetic Tirho relaxation in acute and chronic myocardial infarctions
    Walter R T Witschey; Fiscal Year: 2013
    ..In preliminary investigations performed on swine, T1A was shown to detect changes to the overall apparent exchange rate and rate of relaxation caused by rotational ..
  33. Prevalance of Community-Acquired MRSA in Live Pigs and thier Human Handlers
    LYNDA UJU ODOFIN; Fiscal Year: 2010
    ..Lt will determine if a strain of swine origin exists, and also explore the necessity and feasibility of implementing a nation-wide farm screening scheme ..
  34. Hepatic Insulin Gene Therapy in Swine
    Peter M Thule; Fiscal Year: 2013
    ..b>Swine are a more accurate model of human responses to diabetes mellitus than rodents...
  35. Ultrasound-Assisted AQP1 Gene Therapy for Functional Restoration of Salivary Glan
    Michael J Passineau; Fiscal Year: 2013
    ..Considering the substantial prior work that has been performed in miniature swine as a close-to- man model of salivary gland function, our first aim will be to upscale our UAGT technique in ..
  36. Mechanisms of Myocardial Ischemia and Reperfusion
    Dorothy E Vatner; Fiscal Year: 2010
    ..mechanisms of cardiac protection in the second window of ischemic protection in chronically instrumented conscious swine. The project is based, in part, on the novel observation that either regional cardiac denervation or adrenergic ..
  37. Microcirculation in Renovascular Hypertension
    ALEJANDRO ROBERTO CHADE; Fiscal Year: 2013
    ..We have developed a swine model of RAS that closely mimics the renal functional and structural changes that occur in humans with RAS, ..
  38. TRANSMISSION OF OSELTAMIVIR-RESISTANT INFLUENZA A H1N1 VIRUSES IN GUINEA PIGS
    Nicole M Bouvier; Fiscal Year: 2012
    ..The use of oseltamivir has dramatically increased during the current swine-origin A/H1N1 pandemic [72];this has in turn increased the chances of selecting resistant viruses in novel A/H1N1-..
  39. Therapeutic to Reduce Acute Inflammation Following Cardiac Ischemia
    ELISABETH M ALICOT-CARROLL; Fiscal Year: 2011
    ..Studies described in the application will extend our testing of the inhibitors to a swine model of acute myocardial infarction.
  40. 2009 Spirochetes, Biology of
    David A Haake; Fiscal Year: 2010
    ..syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been very difficult to study...
  41. CHRONIC ADAPTATIONS TO MYOCARDIAL ISCHEMIA
    John M Canty; Fiscal Year: 2013
    ..To ultimately enhance translation, studies will be conducted in swine with a heart size similar to humans...
  42. Bioenergetics in Hypertrophied and Remodeled Left Ventricle
    Jianyi Zhang; Fiscal Year: 2013
    ..Comparing two swine models of LVH secondary to pressure overload or to postinfarction LV remodeling, the effects of MSCs ..
  43. Structural insights into pandemic and emerging influenza viruses
    Ian A Wilson; Fiscal Year: 2013
    ..Furthermore, because we do not understand why certain viruses, such as the recent H1N1 2009 swine flu, are able to enter the human population and cause pandemics, we will also study the molecular basis of ..
  44. Stimulation of broadly neutralizing antibodies against influenza in a pig model
    RADHEY SHYAM KAUSHIK; Fiscal Year: 2011
    ..approached by an interdisciplinary team that consists of David Francis (Co-PI, Pig model), Radhey Kaushik (Co-PI, swine immunology), Feng Li (Investigator, influenza virology) and two swine influenza consultants (Weijun Ma and Mahesh ..
  45. Top Down Proteomics Of Myofilaments In Heart Failure
    Ying Ge; Fiscal Year: 2013
    ..2) Determine altered protein modifications in KMRPs from hypertrophied and failing swine myocardium...
  46. Development of Porcine Genetic Models of Atherosclerosis
    SCOTT CHRISTOPHER FAHRENKRUG; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Because the cardiovascular anatomy of swine is similar to humans with regard to size, morphology, relative collateral arterial supply, and the presence of a well-developed vasa vasorum, the porcine ..
  47. Exercise, Diabetes, &Coronary Smooth Muscle Ca2+
    Michael Sturek; Fiscal Year: 2013
    ..e. peri-stent CAD. Major findings in our previous grant provide outstanding rationale for this project. Ossabaw swine have clinically significant atherosclerosis (>50% stenosis) and we have for the first time stented natural ..
  48. Molecularly guided multimodal theranostics for breast cancer
    Amit Joshi; Fiscal Year: 2013
    ..The developed system and methods will be validated on a clinically relevant Swine based animal model for detecting lymph node locations in three dimensions, following microdose intradermal ..
  49. A Revolutionary Therapy for Atherosclerosis: Liquid Cast Arterial Stents
    Guillermo A Ameer; Fiscal Year: 2010
    ..this system in an ex vivo perfusion circuit;and 4) evaluate the liquid cast NO-eluting PDC stent system in a swine model of atherosclerosis to evaluate the in vivo polymerization of the device as well as overall outcome...
  50. Functional Dynamics of Mammalian and Viral DNA Repair Polymerases
    W M BUJALOWSKI; Fiscal Year: 2013
    ..Mammalian Polymerase ? (pol ?) and African Swine Fever Virus Polymerase X (pol X) provide outstanding model systems to study the molecular mechanism of the DNA ..
  51. Amplification of Cardiosphere-Derived Cell Therapy
    BRIAN RAYMOND WEIL; Fiscal Year: 2013
    ..the capacity of each cell population to elicit improvements in myocardial contractile function and perfusion in swine with hibernating myocardium resulting from a chronic coronary stenosis...
  52. Renovations of the Animal Care Facility
    AWADH AMIR BINHAZIM; Fiscal Year: 2010
    ..Currently the ACF houses mice, rats, rabbits, guinea pigs, and swine. Use of the facility has increased considerably in recent years: in 2007-2008, there were 27 investigators ..
  53. Pre-emptive conditioning of the ischemic heart
    Dorothy E Vatner; Fiscal Year: 2012
    ..We will combine an in vitro system (isolated cardiac myocytes and gene knockdown) with mouse models in vivo (TG and KO) and a pre-clinical model (gene delivery in the swine) to address these goals comprehensively.
  54. Targeting Airway Inflammation from Concentrated Animal Feeding Operation Dust
    Debra Romberger; Fiscal Year: 2013
    ..vivo in a mouse model that has all of the prominent features of the pulmonary disorders seen in persons working in swine confinement facilities...
  55. Linking Spatial Variations in Shear Stress with Oxidation Stress
    Tzung K Hsiai; Fiscal Year: 2013
    ..New Zealand White (NZW) rabbits on a hypercholesterolemic diet, and applied our intravascular methodology to the swine model...
  56. Immune factors in vaccine-enhanced pandemic H1N1 influenza disease
    Amy L Vincent; Fiscal Year: 2013
    ..A similar phenomenon of enhanced disease is observed in pigs after vaccination with an inactivated H1 swine influenza virus, followed by heterologous panH1N1 challenge...
  57. Dynamic of Retroviruses Assembly and Budding
    NOLWENN MONIQUE JOUVENET; Fiscal Year: 2010
    ..and Immunology of the Institute for Animal Health, England, where I studied the intracellular transport of African swine fever virus, a large DNA virus. My work led to the publication of 3 first-author papers...
  58. Impact of Atrial Fibrillation and Surgical Ablation on Atrial Function
    JASON OWEN ROBERTSON; Fiscal Year: 2012
    ..A Hanford mini-swine model of persistent AF will be employed whereby the animals will be atrially paced at 400 bpm with the ventricular ..
  59. Rational design of M2e-FP conserved epitope-based universal influenza A vaccines
    Lanying Du; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The recent global outbreak of influenza A caused by a novel swine-origin H1N1 influenza A virus (S-OIV) has led to a growing concern regarding the pandemic potential of the highly pathogenic avian ..
  60. DNA REPLICATION AND GENE EXPRESSION OF CHLORELLA VIRUSES
    James Van Etten; Fiscal Year: 2009
    ..Thus, chlorella viruses are an important model for studying large nucleocytoplasmic dsDNA viruses because they have evolutionary ties to important mammalian viruses, such as the pox viruses and the quarantined African swine fever virus.
  61. Rational Design of Live Attenuated Influenza A Vaccine Candidates
    Eckard Wimmer; Fiscal Year: 2013
    ..CA07 was the strain responsible for the 2009 H1N1 ("swine flu") pandemic...
  62. Identifying components of Toxoplasma oocysts that confer environmental resistance
    HEATHER MICHELLE FRITZ; Fiscal Year: 2013
    ..g. swine, cattle, sheep) containing bradyzoite tissue cysts, or through congenital transmission...
  63. OZONE INDUCED AIRWAY EPITHELIAL HYPERPROLIFERATION
    CHRISTOPHER MURLAS; Fiscal Year: 1999
    ..For this work, the growth of cells isolated from adult, specific pathogen-free miniature swine will be routinely monitored by serial measurements of cell counts and tritiated thymidine incorporation...
  64. High Throughput Cryopreservation of In Vivo-Derived Swine Embryos
    Randall S Prather; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The current methods for cryopreservation of swine embryos are time consuming and troublesome...
  65. VENTILATION CONTROL TO REDUCE AIRBORNE CONTAMINANTS
    PATRICK O SHAUGHNESSY; Fiscal Year: 2001
    Studies have shown conclusively that airborne contaminant levels in swine confinements are typically of a sufficient level to pose a health hazard to workers in that occupation...
  66. Role of NO and Endothelin in Human NEC
    GAIL BESNER; Fiscal Year: 2007
    ..This hypothesis was initially developed based on work carried out in perinatal swine, in which we demonstrated that the roles of NO and ET-1 in intestinal vascular regulation are substantially ..
  67. MRI-Guided Angioplasty of Renal Artery Stenosis
    Reed Omary; Fiscal Year: 2005
    ..candidate proposes learning: 1) fundamental MRI techniques related to blood vessel imaging and intervention, 2) swine experimental methods, and 3) methods for the responsible conduct of research...
  68. INTESTINAL LIPOPROTEINS IN THE NEONATE
    Dennis Black; Fiscal Year: 2007
    Apolipoprotein A-IV expression is acutely up-regulated 7-fold by a high-fat diet in newborn swine, suggesting a role in lipid absorption...
  69. A Novel Thin Film Nitinol Covered Stent to Treat Peripheral Arterial Disease
    David A Rigberg; Fiscal Year: 2010
    ..Short term preliminary in vivo swine studies have also demonstrated that S-TFN covered stents support endothelial growth without unwanted neointimal ..
  70. REGULATION OF ENDOMETRIAL PROSTAGLANDIN F-2A SECRETION
    MARK MIRANDO; Fiscal Year: 1999
    ..The incidence of early embryonic mortality in swine is approximately 30-40% and is similar to that reported for women...
  71. Chitosan Endoluminal Hemostatic Dressing
    Hua Xie; Fiscal Year: 2009
    ..dressing (CEHD) that can be delivered through a Foley catheter to control and prevent urethral bleeding in a swine model...
  72. Population-based Surveillance for Zoonotic Influenza A
    Gregory Gray; Fiscal Year: 2005
    ..In the last 10 years, human influenza has caused severe morbidity among US domestic swine, herds, avian influenza has caused the destruction of large poultry flocks in Virginia and North Carolina, and ..
  73. Nipah Virus Marker Vaccine and Companion Diagnostic Test
    James Roth; Fiscal Year: 2005
    Nipah virus infection is an emerging new disease of humans and swine, first described during a 1998-1999 epidemic in Malaysia...
  74. FACILITY RENOVATION AND ANNENBERG CAGE WASH FACILITIY
    Kenneth Davis; Fiscal Year: 2003
    ..continues to expand at MSSM; however, there is also concurrently an increase in the use of large animal species (swine, sheep primarily)...
  75. OPIATE MODULATION OF PULMONARY INFECTION
    Thomas Molitor; Fiscal Year: 2000
    ..bovis infection. To test the hypothesis, both in vitro and in vivo experiments will be conducted using a swine model of disseminated TB. The specific aims are to: (1) characterize the effect of morphine in vitro on M...
  76. Contrast-Enhanced Ultrasound Detection of Secondary Lymph Nodes
    Barry B Goldberg; Fiscal Year: 2010
    ..Investigations using a melanoma swine model have demonstrated the superior accuracy of contrast-enhanced ultrasound (CEUS) compared to scintigraphy for ..
  77. HORMONE ACTION IN THE OVARY: ROLE OF CALCIUM IONS
    Johannes Veldhuis; Fiscal Year: 1999
    ..Notably, in gonadal target cells bearing native gonadotropin receptors (e.g. swine granulosa and rat Sertoli cells), FSH and LH both stimulate adenyl cyclase, but each gonadotropin also activates a ..
  78. ZOONOTIC AND XENOZOONOTIC RISKS OF HEPATITIS E VIRUS
    Xiang Jin Meng; Fiscal Year: 2001
    ..Recently, a strain of HEV was identified in pigs in the United States (U.S.) and designated as swine HEV...
  79. Immunopathogenesis of Chronic Allograft Rejection
    MOHAMED SAYEGH; Fiscal Year: 2005
    ..focus on studying the immunopathogenesis of chronic rejection using clinically relevant large animal (miniature swine) models of heart and lung transplantation...
  80. IMAGING INTIMAL HYPERPLASIA, MYOCYTE HYPOXIA, NECROSIS
    Lynne Johnson; Fiscal Year: 2000
    ..In preliminary experiments, the applicants reported documenting in vivo uptake of In-111 Z2D3 in a swine model of stent overexpansion restenosis, but there was no correlation between the extent of neointimal ..