sheep

Summary

Summary: Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.

Top Publications

  1. doi Accuracy of genotype imputation in sheep breeds
    B J Hayes
    Biosciences Research Division, Department of Primary Industries, 1 Park Drive, Bundoora, Victoria 3083, Australia
    Anim Genet 43:72-80. 2012
  2. pmc Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection
    James W Kijas
    Livestock Industries, CSIRO, Brisbane, Australia
    PLoS Biol 10:e1001258. 2012
  3. doi Small ruminant lentiviruses: immunopathogenesis of visna-maedi and caprine arthritis and encephalitis virus
    Barbara A Blacklaws
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Comp Immunol Microbiol Infect Dis 35:259-69. 2012
  4. ncbi A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
    Alex Clop
    Unit of Animal Genomics, Department of Animal Production, Faculty of Veterinary Medicine and Centre for Biomedical Integrative Genoproteomics, University of Liège B43, 20 Boulevard de Colonster, 4000 Liege, Belgium
    Nat Genet 38:813-8. 2006
  5. pmc Cells release prions in association with exosomes
    Benoit Fevrier
    Centre National de la Recherche Scientifique, Unite Mixte de Recherche 144, Institut Curie, 75005 Paris, France
    Proc Natl Acad Sci U S A 101:9683-8. 2004
  6. doi The Q fever epidemic in The Netherlands: history, onset, response and reflection
    H I J Roest
    Department of Bacteriology and TSEs, Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands
    Epidemiol Infect 139:1-12. 2011
  7. ncbi Novel proteinaceous infectious particles cause scrapie
    S B Prusiner
    Science 216:136-44. 1982
  8. doi A goat poxvirus-vectored peste-des-petits-ruminants vaccine induces long-lasting neutralization antibody to high levels in goats and sheep
    Weiye Chen
    Key Laboratory of Veterinary Public Health of Ministry of Agriculture and State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, PR China
    Vaccine 28:4742-50. 2010
  9. doi A genome scan for QTL affecting resistance to Haemonchus contortus in sheep
    G Salle
    INRA, UR631, Station d Amélioration Génétique des Animaux, BP 27, F 31326, Castanet Tolosan, France
    J Anim Sci 90:4690-705. 2012
  10. doi The pathology and pathogenesis of bluetongue
    N J MacLachlan
    Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Comp Pathol 141:1-16. 2009

Detail Information

Publications373 found, 100 shown here

  1. doi Accuracy of genotype imputation in sheep breeds
    B J Hayes
    Biosciences Research Division, Department of Primary Industries, 1 Park Drive, Bundoora, Victoria 3083, Australia
    Anim Genet 43:72-80. 2012
    Although genomic selection offers the prospect of improving the rate of genetic gain in meat, wool and dairy sheep breeding programs, the key constraint is likely to be the cost of genotyping...
  2. pmc Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection
    James W Kijas
    Livestock Industries, CSIRO, Brisbane, Australia
    PLoS Biol 10:e1001258. 2012
    Through their domestication and subsequent selection, sheep have been adapted to thrive in a diverse range of environments...
  3. doi Small ruminant lentiviruses: immunopathogenesis of visna-maedi and caprine arthritis and encephalitis virus
    Barbara A Blacklaws
    Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK
    Comp Immunol Microbiol Infect Dis 35:259-69. 2012
    ..Infection of sheep or goats with these viruses causes slow, progressive, inflammatory pathology in many tissues, but the most common ..
  4. ncbi A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep
    Alex Clop
    Unit of Animal Genomics, Department of Animal Production, Faculty of Veterinary Medicine and Centre for Biomedical Integrative Genoproteomics, University of Liège B43, 20 Boulevard de Colonster, 4000 Liege, Belgium
    Nat Genet 38:813-8. 2006
    Texel sheep are renowned for their exceptional meatiness. To identify the genes underlying this economically important feature, we performed a whole-genome scan in a Romanov x Texel F2 population...
  5. pmc Cells release prions in association with exosomes
    Benoit Fevrier
    Centre National de la Recherche Scientifique, Unite Mixte de Recherche 144, Institut Curie, 75005 Paris, France
    Proc Natl Acad Sci U S A 101:9683-8. 2004
    ..were actively released into the extracellular environment by PrP-expressing cells before and after infection with sheep prions, respectively...
  6. doi The Q fever epidemic in The Netherlands: history, onset, response and reflection
    H I J Roest
    Department of Bacteriology and TSEs, Central Veterinary Institute of Wageningen UR, Lelystad, The Netherlands
    Epidemiol Infect 139:1-12. 2011
    ..Q fever was endemic in The Netherlands several decades before the disease was diagnosed in dairy goats and dairy sheep. This was in 2005 and the increase in humans started in 2007...
  7. ncbi Novel proteinaceous infectious particles cause scrapie
    S B Prusiner
    Science 216:136-44. 1982
    ..a prolonged incubation period, the scrapie agent causes a degenerative disease of the central nervous system in sheep and goats...
  8. doi A goat poxvirus-vectored peste-des-petits-ruminants vaccine induces long-lasting neutralization antibody to high levels in goats and sheep
    Weiye Chen
    Key Laboratory of Veterinary Public Health of Ministry of Agriculture and State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, PR China
    Vaccine 28:4742-50. 2010
    ..The immunogenicity of this vectored vaccine in goats and sheep, however, has not been fully evaluated...
  9. doi A genome scan for QTL affecting resistance to Haemonchus contortus in sheep
    G Salle
    INRA, UR631, Station d Amélioration Génétique des Animaux, BP 27, F 31326, Castanet Tolosan, France
    J Anim Sci 90:4690-705. 2012
    Gastrointestinal nematodes are one of the main health issues in sheep breeding. To identify loci affecting the resistance to Haemonchus contortus, a genome scan was carried out using 1,275 Romane × Martinik Black Belly backcross lambs...
  10. doi The pathology and pathogenesis of bluetongue
    N J MacLachlan
    Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Comp Pathol 141:1-16. 2009
    ..Amongst domestic livestock, BT is most common in certain breeds of sheep whereas asymptomatic BT virus (BTV) infection of cattle is typical in enzootic regions...
  11. ncbi Viable offspring derived from fetal and adult mammalian cells
    I Wilmut
    Roslin Institute Edinburgh, Roslin, Midlothian, UK
    Nature 385:810-3. 1997
    ....
  12. ncbi A subset of skin-expressed microRNAs with possible roles in goat and sheep hair growth based on expression profiling of mammalian microRNAs
    Zhang Wenguang
    Key Laboratory of Animal Genetics, Breeding and Reproduction, Nei Mongol Autonomous Region, Hohhot, PR China
    OMICS 11:385-96. 2007
    ..in hair growth, we characterized the expression of 159 miRNAs in adult body side skin and ear skin from goat and sheep using microarray analysis...
  13. pmc Airway injury from initiating ventilation in preterm sheep
    Noah H Hillman
    Division of Pulmonary Biology, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Pediatr Res 67:60-5. 2010
    ..We report where injury occurred within the lung after brief ventilation at birth. Preterm sheep (129 d gestation) were ventilated with an escalating tidal volume to 15 mL/kg by 15 min to injure the lungs, with ..
  14. ncbi Sex-specific effects of placental restriction on components of the metabolic syndrome in young adult sheep
    J A Owens
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia
    Am J Physiol Endocrinol Metab 292:E1879-89. 2007
    ..the effects of restricted placental and fetal growth on components of the metabolic syndrome in young adult sheep and the relationships of the latter to size at birth and early postnatal growth...
  15. pmc Histopathological correlates of magnetic resonance imaging-defined chronic perinatal white matter injury
    Art Riddle
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Ann Neurol 70:493-507. 2011
    ..We determined whether ex vivo MRI can distinguish distinct microglial and astroglial responses related to WMI progression and arrested preOL differentiation...
  16. pmc Prionemia and leukocyte-platelet-associated infectivity in sheep transmissible spongiform encephalopathy models
    Caroline Lacroux
    UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Veterinaire de Toulouse, Toulouse, France
    J Virol 86:2056-66. 2012
    ..Using two distinct sheep scrapie models and blood transfusion, this work demonstrates the occurrence of a very early and persistent ..
  17. pmc Ovine TRIM5α can restrict visna/maedi virus
    P Jáuregui
    Instituto de Agrobiotecnologia, CSIC UPNA Gobierno de Navarra, Mutilva Baja, Navarra, Spain
    J Virol 86:9504-9. 2012
    ..Here, we identify highly similar TRIM5α sequences in sheep and goats...
  18. doi Delayed cortical impairment following lipopolysaccharide exposure in preterm fetal sheep
    Justin M Dean
    Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Ann Neurol 70:846-56. 2011
    ..the effect of fetal lipopolysaccharide (LPS) exposure on WM and cortical development as assessed by magnetic resonance imaging (MRI), electroencephalography (EEG), and histopathology in fetal sheep at preterm human equivalent age.
  19. ncbi The foot-and-mouth epidemic in Great Britain: pattern of spread and impact of interventions
    N M Ferguson
    Department of Infectious Disease Epidemiology, Imperial College School of Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Science 292:1155-60. 2001
    ..Culling is predicted to be more effective than vaccination...
  20. doi A deletion in the bone morphogenetic protein 15 gene causes sterility and increased prolificacy in Rasa Aragonesa sheep
    A Martinez-Royo
    CITA, Unidad de Tecnologia en Produccion Animal, 50059 Zaragoza, Spain
    Anim Genet 39:294-7. 2008
    ..of the transforming growth factor beta superfamily, is specifically expressed in oocytes and is essential for sheep prolificacy...
  21. doi Oocyte mitochondrial bioenergy potential and oxidative stress: within-/between-subject, in vivo versus in vitro maturation, and age-related variations in a sheep model
    Nicola Antonio Martino
    Department of Animal Production, Aldo Moro University of Bari, Bari, Italy
    Fertil Steril 97:720-8.e1. 2012
    ..within-/between-subject, in vivo versus in vitro maturation (IVM), and age-related variations of mitochondrial (mt) bioenergy potential and oxidative status of metaphase II (MII) oocytes recovered from hormonally stimulated sheep.
  22. ncbi Routes of transmission and consequences of small ruminant lentiviruses (SRLVs) infection and eradication schemes
    Ernst Peterhans
    Institute of Veterinary Virology, University of Bern, Bern, Switzerland
    Vet Res 35:257-74. 2004
    Small ruminant lentiviruses (SRLV = maedi-visna in sheep and caprine arthritis encephalitis in goats) are distributed throughout most countries of the world, particularly Europe...
  23. doi Proteomic characterisation of Echinococcus granulosus hydatid cyst fluid from sheep, cattle and humans
    Ammar Aziz
    Qld Tropical Health Alliance, James Cook University, Queensland, 4870, Australia
    J Proteomics 74:1560-72. 2011
    ..fractionation techniques and tandem mass spectrometry 130 HCF proteins were identified from fertile cysts of sheep and human origin and infertile cysts from cattle...
  24. doi Staphylococcus aureus host specificity: comparative genomics of human versus animal isolates by multi-strain microarray
    Julia M L Sung
    Centre for Infection, Department of Cellular and Molecular Medicine, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Microbiology 154:1949-59. 2008
    ..aureus microarray, we compared 56 UK S. aureus isolates that caused infection in cows, horses, goats, sheep and a camel with 161 human S. aureus isolates from healthy carriers and community acquired infections in the UK...
  25. doi Prenatal glucocorticoid exposure in the sheep alters renal development in utero: implications for adult renal function and blood pressure control
    Karen M Moritz
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Australia
    Am J Physiol Regul Integr Comp Physiol 301:R500-9. 2011
    ..In adulthood, sheep treated with dexamethasone or cortisol in utero had elevated arterial pressure and an apparent increase in single ..
  26. ncbi Dynamics of the 2001 UK foot and mouth epidemic: stochastic dispersal in a heterogeneous landscape
    M J Keeling
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Science 294:813-7. 2001
    ..We assess the history and possible duration of the epidemic, the performance of control strategies, and general implications for disease dynamics in space and time...
  27. ncbi Effect of ewe ovine lentivirus infection on ewe and lamb productivity
    J E Keen
    US Meat Animal Research Center, USDA, Clay Center, NE 68933, USA
    Prev Vet Med 30:155-69. 1997
    ..Our results suggest that subclinical OLV infection has important detrimental effects on sheep production which occur in cumulative fashion from breeding through weaning and that OLV control efforts may be ..
  28. ncbi Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten disease
    Ruming Chen
    Medical Research Council Dunn Human Nutrition Unit, Wellcome Trust Medical Research Council Building, Hills Road, Cambridge, CB2 2XY, United Kingdom
    J Biol Chem 279:21883-7. 2004
    ..The residue and the modification are not conserved in all ATP synthases, and their role in the assembly and (or) functioning of the enzyme appear to be confined to higher organisms...
  29. doi Prevention strategies against small ruminant lentiviruses: an update
    Ramses Reina
    Institute of Agrobiotechnology CSIC UPNA Government of Navarra, 31192 Mutilva Baja, Spain
    Vet J 182:31-7. 2009
    Small ruminant lentiviruses (SRLVs), including maedi-visna virus (MVV) of sheep and caprine arthritis-encephalitis virus (CAEV), are widespread, cause fatal diseases and are responsible for major production losses in sheep and goats...
  30. doi Mapping the basic reproduction number (R₀) for vector-borne diseases: a case study on bluetongue virus
    N A Hartemink
    Theoretical Epidemiology, Veterinary Medicine, Utrecht, The Netherlands
    Epidemics 1:153-61. 2009
    ....
  31. ncbi Compensatory renal growth after unilateral nephrectomy in the ovine fetus
    Rebecca Douglas-Denton
    Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia
    J Am Soc Nephrol 13:406-10. 2002
    ..amount of compensatory growth and nephron endowment in a remaining kidney after unilateral nephrectomy during the period of active nephrogenesis in the sheep. This is the first time such events have been shown to occur in utero.
  32. doi Efficacy of three inactivated vaccines against bluetongue virus serotype 8 in sheep
    Michael Eschbaumer
    Institute of Diagnostic Virology, Friedrich Loeffler Institut, Südufer 10, 17493 Greifswald Insel Riems, Germany
    Vaccine 27:4169-75. 2009
    ..The efficacy of these vaccines was evaluated in a pilot study in sheep immunised under field conditions by clinical, virological and serological examination before and after ..
  33. pmc Accumulation and dissemination of prion protein in experimental sheep scrapie in the natural host
    Stephen J Ryder
    Department of Pathology, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey KT153NB, UK
    BMC Vet Res 5:9. 2009
    ..This model provides an excellent system in which to study the disease in the natural host by virtue of the relatively short incubation period and close resemblance to natural infection...
  34. ncbi Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture
    L E Young
    Roslin Institute Edinburgh, Roslin, Midlothian, Scotland, UK
    Nat Genet 27:153-4. 2001
    ..This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures...
  35. ncbi Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha
    I Franceschini
    UMR 6175 INRA CNRS UniversityTours Haras Nationaux, IFR 135, 37380 Nouzilly, France
    Neurosci Lett 401:225-30. 2006
    ..The pattern of distribution of kp10 immunoreactivity in the hypothalamus suggests a role for kisspeptin in the estrogen-dependent regulation of GnRH and LH secretion in the ewe...
  36. pmc Novel bluetongue virus serotype from Kuwait
    Sushila Maan
    Institute for Animal Health, Woking, UK
    Emerg Infect Dis 17:886-9. 2011
    b>Sheep and goats sampled in Kuwait during February 2010 were seropositive for bluetongue virus (BTV)...
  37. doi The 2006 outbreak of bluetongue in northern Europe--the entomological perspective
    R Meiswinkel
    Central Veterinary Institute of Wageningen UR, P O Box 65, 8200 AB Lelystad, The Netherlands
    Prev Vet Med 87:55-63. 2008
    ..obsoletus/C. scoticus and C. dewulfi occurred also widely and abundantly on sheep and cattle holdings across the entire affected region, (v) and during the latter part of the season showed strong ..
  38. pmc Bluetongue in Europe: past, present and future
    Anthony J Wilson
    Institute for Animal Health Pirbright Laboratory, Pirbright, Woking, Surrey GU24 0NF, UK
    Philos Trans R Soc Lond B Biol Sci 364:2669-81. 2009
    ..Although attempts are being made to improve the capacity of European countries to cope with future BTV incursions, the options available are limited by a lack of basic entomological data and limited virological surveillance...
  39. pmc Histological and transcriptome-wide level characteristics of fetal myofiber hyperplasia during the second half of gestation in Texel and Ujumqin sheep
    Hangxing Ren
    National Center for Molecular Genetics and Breeding of Animal, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China
    BMC Genomics 12:411. 2011
    ..Additionally, the molecular mechanisms of myostatin in myofiber hyperplasia at the fetal stage in sheep remain unknown...
  40. doi A new polymorphism in the Growth and Differentiation Factor 9 (GDF9) gene is associated with increased ovulation rate and prolificacy in homozygous sheep
    B D M Silva
    Universidade de Brasilia, Brasilia, Brazil
    Anim Genet 42:89-92. 2011
    Brazilian Santa Inês (SI) sheep are very well-adapted to the tropical conditions of Brazil and are an important source of animal protein. A high rate of twin births was reported in some SI flocks...
  41. pmc Causes of pneumonia epizootics among bighorn sheep, Western United States, 2008-2010
    Thomas E Besser
    Washington Animal Disease Diagnostic Laboratory, PO Box 647034, Washington State University, Pullman, WA 99164 7034, USA
    Emerg Infect Dis 18:406-14. 2012
    Epizootic pneumonia of bighorn sheep is a devastating disease of uncertain etiology...
  42. pmc Genetic testing for TMEM154 mutations associated with lentivirus susceptibility in sheep
    Michael P Heaton
    U S Meat Animal Research Center USMARC, Clay Center, Nebraska, USA
    PLoS ONE 8:e55490. 2013
    In sheep, small ruminant lentiviruses cause an incurable, progressive, lymphoproliferative disease that affects millions of animals worldwide. Known as ovine progressive pneumonia virus (OPPV) in the U.S...
  43. pmc A modeling framework to describe the transmission of bluetongue virus within and between farms in Great Britain
    Camille Szmaragd
    Institute for Animal Health, Pirbright Laboratory, Pirbright, Surrey, United Kingdom
    PLoS ONE 4:e7741. 2009
    ..Yet BT has emerged over the past decade as one of the most important diseases of livestock...
  44. doi Sensitivity and specificity of various serological tests for the detection of Toxoplasma gondii infection in naturally infected sheep
    R M Shaapan
    Department of Zoonosis, National Research Center, Giza, Egypt
    Vet Parasitol 153:359-62. 2008
    Comparative serological examination of 300 serum samples from sheep slaughtered in the main abattoir in Cairo, Egypt revealed a higher prevalence of toxoplasmosis (43...
  45. doi Impacts of climate, host and landscape factors on Culicoides species in Scotland
    B V Purse
    NERC Centre for Ecology and Hydrology, Penicuik, U K
    Med Vet Entomol 26:168-77. 2012
    ..Modelling approaches that may facilitate the more accurate prediction of local abundance patterns for a wider range of Culicoides species are discussed...
  46. ncbi Prevention and control of cystic echinococcosis
    Philip S Craig
    Cestode Zoonoses Research Group, School of Environment and Life Sciences, University of Salford, Salford, UK
    Lancet Infect Dis 7:385-94. 2007
    ..Incorporation of these new measures could increase the efficiency of hydatid control programmes, potentially reducing the time required to achieve effective prevention of disease transmission to as little as 5-10 years...
  47. ncbi The FAMACHA system for managing haemonchosis in sheep and goats by clinically identifying individual animals for treatment
    Jan A van Wyk
    Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa
    Vet Res 33:509-29. 2002
    ..Trials over several seasons showed that most sheep under severe Haemonchus contortus challenge required no, or only one treatment over a full summer season...
  48. doi Genomic selection in the French Lacaune dairy sheep breed
    S I Duchemin
    Institut National de la Recherche Agronomique INRA, UR631, Station d Amélioration Génétique des Animaux SAGA, Castanet Tolosan, France
    J Dairy Sci 95:2723-33. 2012
    ..Using real data of the French Lacaune dairy sheep breed, the purpose of this study was to compare the observed accuracies of genomic estimated breeding values using ..
  49. pmc Development and validation of an ovine progressive pneumonia virus quantitative PCR
    Lynn M Herrmann-Hoesing
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Washington State University, Pullman, WA 99164 6630, USA
    Clin Vaccine Immunol 14:1274-8. 2007
    Ovine progressive pneumonia virus (OPPV) infects at least one sheep in 81% of U.S. sheep flocks, as determined by serology, and can cause viral mastitis, arthritis, dyspnea, and cachexia...
  50. doi Characterization of new small ruminant lentivirus subtype B3 suggests animal trade within the Mediterranean Basin
    L Bertolotti
    Dipartimento di Produzioni Animali, Universita degli Studi di Torino, Grugliasco, Italy
    J Gen Virol 92:1923-9. 2011
    Small ruminant lentiviruses (SRLVs) represent a group of viruses infecting sheep and goats worldwide...
  51. doi A combined microscopic-molecular method for the diagnosis of strongylid infections in sheep
    Nathan J Bott
    Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, VIC 3030, Australia
    Int J Parasitol 39:1277-87. 2009
    We evaluated a combined microscopic-molecular approach for the diagnosis of key strongylid infections in sheep using panels of well-defined control and test samples...
  52. doi Genetic and antigenic characterization of small ruminant lentiviruses circulating in Poland
    Monika Olech
    Department of Biochemistry, National Veterinary Research Institute, 24 100 Pulawy, Poland
    Virus Res 163:528-36. 2012
    Small ruminant lentivirus (SRLV) infections are widespread in Poland, but the genetic features of sheep viruses are still lacking and limited to partial gag sequences for goat viruses...
  53. pmc The instrumented fetal sheep as a model of cerebral white matter injury in the premature infant
    Stephen A Back
    Department of Pediatrics, Oregon Health Sciences University, Portland, OR 97239, USA
    Neurotherapeutics 9:359-70. 2012
    ..Cerebral white matter development in fetal sheep shares many anatomical and physiological similarities with humans...
  54. doi Homozygosity for a single base-pair mutation in the oocyte-specific GDF9 gene results in sterility in Thoka sheep
    Linda Nicol
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Reproduction 138:921-33. 2009
    ..Previously, several mutations have been identified in sheep which increase the naturally low ovulation rate; although in some cases homozygous ewes are infertile...
  55. pmc Infection of dendritic cells by the Maedi-Visna lentivirus
    S Ryan
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 OES, United Kingdom
    J Virol 74:10096-103. 2000
    ..Maedi-visna virus (MVV) is a natural pathogen of sheep with a tropism for macrophages, but the infection of dendritic cells has not been proven, largely because of the ..
  56. pmc Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation
    Caitriona M Guinane
    The Roslin Institute and Centre for Infectious Diseases, Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Genome Biol Evol 2:454-66. 2010
    ..For example, the capacity of Staphylococcus aureus from sheep to coagulate ruminant plasma, reported over 60 years ago, led to the description of small ruminant and bovine S...
  57. doi An innovative survey underlining the significant level of contamination by Toxoplasma gondii of ovine meat consumed in France
    Lénaïg Halos
    ENVA AFSSA INRA UMR BIPAR, National Reference Laboratory for Food Borne Parasites, 23 Avenue du Général de Gaulle, 94700 Maisons Alfort, France
    Int J Parasitol 40:193-200. 2010
    Consumption of sheep meat presents a risk of human contamination by Toxoplasma gondii. A nationwide study was conducted in France to evaluate the prevalence of Toxoplasma in fresh ovine meat...
  58. ncbi Maedi-visna virus and its relationship to human immunodeficiency virus
    Halldor Thormar
    University of Iceland, Institute of Biology, Sturlugata 7, 101 Reykjavik, Iceland
    AIDS Rev 7:233-45. 2005
    Maedi-visna is a slow virus infection of sheep leading to a progressing lymphoproliferative disease which is invariably fatal. It affects multiple organs, but primarily the lungs where it causes interstitial pneumonia (maedi)...
  59. ncbi Age, sex, density, winter weather, and population crashes in Soay sheep
    T Coulson
    Institute of Zoology, Zoological Society of London, Regent s Park, London NW1 4RY, UK
    Science 292:1528-31. 2001
    ..We analyzed the effect of these processes on the irregular pattern of population crashes of Soay sheep on the St. Kilda archipelago, United Kingdom...
  60. pmc Highly efficient prion transmission by blood transfusion
    Olivier Andreoletti
    UMR INRA ENVT 1225, Interactions Hôtes Agents Pathogènes, Ecole Nationale Veterinaire de Toulouse, Toulouse, France
    PLoS Pathog 8:e1002782. 2012
    ..the efficiency of TSE transmission by blood and blood components when administrated either through transfusion in sheep or by intra-cerebral inoculation (IC) in transgenic mice (tg338) over-expressing ovine PrP...
  61. pmc A novel nonsense mutation in the DMP1 gene identified by a genome-wide association study is responsible for inherited rickets in Corriedale sheep
    Xia Zhao
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa, United States of America
    PLoS ONE 6:e21739. 2011
    Inherited rickets of Corriedale sheep is characterized by decreased growth rate, thoracic lordosis and angular limb deformities. Previous outcross and backcross studies implicate inheritance as a simple autosomal recessive disorder...
  62. doi A first comparative map of copy number variations in the sheep genome
    L Fontanesi
    DIPROVAL, Sezione di Allevamenti Zootecnici, University of Bologna, Via F lli Rosselli 107, 42123 Reggio Emilia, Italy
    Genomics 97:158-65. 2011
    We carried out a cross species cattle-sheep array comparative genome hybridization experiment to identify copy number variations (CNVs) in the sheep genome analysing ewes of Italian dairy or dual-purpose breeds (Bagnolese, Comisana, ..
  63. ncbi Epizootic of ovine congenital malformations associated with Schmallenberg virus infection
    R van den Brom
    Department of Small Ruminant Health, Animal Health Service, Deventer, The Netherlands
    Tijdschr Diergeneeskd 137:106-11. 2012
    Epizootic outbreaks of congenital malformations in sheep are rare and have, to the best of our knowledge, never been reported before in Europe...
  64. ncbi Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive manner
    S M Galloway
    AgResearch Molecular Biology Unit, and Centre for Gene Research, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Nat Genet 25:279-83. 2000
    Multiple ovulations are uncommon in humans, cattle and many breeds of sheep. Pituitary gonadotrophins and as yet unidentified ovarian factors precisely regulate follicular development so that, normally, only one follicle is selected to ..
  65. ncbi Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries)
    James P Hanrahan
    Teagasc, Research Centre, Athenry, County Galway, Ireland
    Biol Reprod 70:900-9. 2004
    Belclare and Cambridge are prolific sheep breeds, the origins of which involved selecting ewes with exceptionally high litter size records from commercial flocks...
  66. ncbi Transmission of small ruminant lentiviruses
    B A Blacklaws
    Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Vet Microbiol 101:199-208. 2004
    ..However, such transmission has not been demonstrated to date. The application of control measures based on this information allows more efficient strategies to be developed which will reduce the rate of transmission...
  67. doi High prevalence and abundant atypical genotypes of Toxoplasma gondii isolated from lambs destined for human consumption in the USA
    J P Dubey
    United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Beltsville, MD 20705 2350, USA
    Int J Parasitol 38:999-1006. 2008
    ..gondii in lambs, which has important implications in public health. We believe this is the first in-depth genetic analysis of T. gondii isolates from sheep in the USA.
  68. pmc Microphthalmia in Texel sheep is associated with a missense mutation in the paired-like homeodomain 3 (PITX3) gene
    Doreen Becker
    Institute of Genetics, Vetsuisse Faculty, University of Berne, Berne, Switzerland
    PLoS ONE 5:e8689. 2010
    Microphthalmia in sheep is an autosomal recessive inherited congenital anomaly found within the Texel breed. It is characterized by extremely small or absent eyes and affected lambs are absolutely blind...
  69. ncbi Descriptive epidemiology of the 2001 foot-and-mouth disease epidemic in Great Britain: the first five months
    J C Gibbens
    Veterinary Service, DEFRA, London
    Vet Rec 149:729-43. 2001
    ..result of a combination of events, including a delay in the diagnosis of the index case, the movement of infected sheep to market before FMD was first diagnosed, and the time of year...
  70. pmc Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 176:575-81. 2007
    ..Premature infants are exposed to potentially injurious ventilation in the delivery room. Assessments of lung injury are confounded by effects of subsequent ventilatory support...
  71. ncbi Ovine lentivirus-infected macrophages mediate productive infection in cell types that are not susceptible to infection with cell-free virus
    D K Singh
    Department of Microbiology, Kansas University Medical Center, Kansas City 66160 7424, USA
    J Gen Virol 80:1437-44. 1999
    ..This strategy could be one of the mechanisms involved in the escape from immune surveillance and establishment of persistent infection in infected animals...
  72. pmc A gene duplication affecting expression of the ovine ASIP gene is responsible for white and black sheep
    Belinda J Norris
    CSIRO Livestock Industries, Queensland Bioscience Precinct, St Lucia, Queensland, Australia
    Genome Res 18:1282-93. 2008
    ..regions and the ITCH promoter region as the genetic cause of white coat color of dominant white/tan (A(Wt)) agouti sheep. The duplication 5' breakpoint is located upstream of the ASIP coding sequence...
  73. doi The effect of platelet rich plasma combined with microfractures on the treatment of chondral defects: an experimental study in a sheep model
    G Milano
    Department of Orthopaedics, Catholic University, Rome, Italy
    Osteoarthritis Cartilage 18:971-80. 2010
    ..To evaluate the effect of autologous platelet rich plasma (PRP) combined with microfractures on the treatment of chondral defects. The hypothesis of the study was that PRP can enhance cartilage repair after microfractures...
  74. ncbi Feasibility and implications of breeding sheep for resilience to nematode challenge
    S A Bisset
    AgResearch Wallaceville, Upper Hutt, New Zealand
    Int J Parasitol 26:857-68. 1996
    There are potentially 2 different types of host response which could be targeted when seeking to breed sheep which require minimal frequency of anthelmintic treatment to maintain acceptable health and productivity in the face of nematode ..
  75. pmc The physical relationship between infectivity and prion protein aggregates is strain-dependent
    Philippe Tixador
    INRA Institut National de la recherche Agronomique, UR892, Virologie Immunologie Moléculaires, Jouy en Josas, France
    PLoS Pathog 6:e1000859. 2010
    ..technique to a panel of natural, biologically cloned strains obtained by propagation of classical and atypical sheep scrapie and BSE infectious sources in transgenic mice expressing ovine PrP...
  76. ncbi Strain typing of German transmissible spongiform encephalopathies field cases in small ruminants by biochemical methods
    A Gretzschel
    Friedrich Loeffler Institut FLI, Institute for Novel and Emerging Diseases, Insel Riems, Germany
    J Vet Med B Infect Dis Vet Public Health 52:55-63. 2005
    ..In this national survey, 186 scrapie-affected sheep were found which originated from 78 flocks...
  77. doi In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapie
    Leigh Thorne
    Department of Molecular Pathogenesis and Genetics, Veterinary Laboratories Agency, New Haw, Addlestone, Surrey KT15 3NB, UK
    J Gen Virol 89:3177-84. 2008
    Scrapie is a fatal, naturally transmissible, neurodegenerative prion disease that affects sheep and goats and is characterized by the accumulation of a misfolded protein, PrPSc, converted from host-encoded PrPc, in the central nervous ..
  78. pmc AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep
    Mei J Zhu
    Department of Animal Science and Interdepartmental Molecular and Cellular Life Sciences Program, University of Wyoming, Laramie, WY 82071, USA
    J Physiol 586:2651-64. 2008
    ..on signalling of the AMP-activated protein kinase (AMPK) pathway in fetal skeletal muscle in an obese pregnant sheep model...
  79. ncbi Is the decline of desert bighorn sheep from infectious disease the result of low MHC variation?
    G A Gutierrez-Espeleta
    Department of Biology, Arizona State University, Tempe, Arizona 85287, USA
    Heredity 86:439-50. 2001
    Bighorn sheep populations have greatly declined in numbers and distribution since European settlement, primarily because of high susceptibility to infectious diseases transmitted to them from domestic livestock...
  80. ncbi Regenerative versus reparative healing in tendon: a study of biomechanical and histological properties in fetal sheep
    Pedro K Beredjiklian
    McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA, USA
    Ann Biomed Eng 31:1143-52. 2003
    ..A better understanding of the mechanisms of fetal healing may lead to novel therapeutic strategies in the clinical setting...
  81. pmc Bluetongue epidemiology in the European Union
    Claude Saegerman
    Department of Infectious and Parasitic Diseases, Epidemiology and Risk Analysis Applied to Veterinary, University of Liege, Liege, Belgium
    Emerg Infect Dis 14:539-44. 2008
    ..This condition increases the risk for reassortment of individual BTV gene segments...
  82. pmc Re-emergence of bluetongue, African horse sickness, and other orbivirus diseases
    N James MacLachlan
    Department of Pathology, Microbiology and Immunology, University of California, Davis, CA 95616, USA
    Vet Res 41:35. 2010
    ....
  83. pmc Lentiviral Vif degrades the APOBEC3Z3/APOBEC3H protein of its mammalian host and is capable of cross-species activity
    Rebecca S LaRue
    Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, and Comparative and Molecular Biology Graduate Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Virol 84:8193-201. 2010
    ..SIV(mac) Vif can mediate the degradation of the human, macaque, and cow A3Z3-type proteins but not of the sheep or cat A3Z3-type proteins...
  84. ncbi Effect of corticosteroids on brain growth in fetal sheep
    W L Huang
    Department of Zoology, The University of Western Australia, Nedlands, Australia
    Obstet Gynecol 94:213-8. 1999
    To compare the effects of single and repeated courses of corticosteroids on brain growth in fetal sheep.
  85. ncbi Strain characterization of natural sheep scrapie and comparison with BSE
    Moira E Bruce
    Institute for Animal Health, Neuropathogenesis Unit, Ogston Building, West Mains Road, Edinburgh EH9 3JF, UK
    J Gen Virol 83:695-704. 2002
    Scrapie was transmitted to mice from ten sheep, collected in the UK between 1985 and 1994...
  86. pmc New vectors of Rift Valley fever in West Africa
    D Fontenille
    Laboratoire de Zoologie Medicale, Institut Pasteur, Dakar, Senegal
    Emerg Infect Dis 4:289-93. 1998
    ..from the main vectors in East and South Africa, they use the same type of breeding sites and also feed on cattle and sheep. Although enzootic vectors have now been identified in West Africa, the factors causing outbreaks remain unclear.
  87. doi Natural interspecies recombinant bovine/porcine enterovirus in sheep
    Akos Boros
    Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ANTSZ Regional Institute of State Public Health Service, H 7623, Szabadság út 7, Pecs, Hungary
    J Gen Virol 93:1941-51. 2012
    ..enterovirus (ovine enterovirus type 1; OEV-1) in seven (44 %) of 16 faecal samples from 3-week-old domestic sheep (Ovis aries) collected in two consecutive years...
  88. pmc Proteinase K-resistant material in ARR/VRQ sheep brain affected with classical scrapie is composed mainly of VRQ prion protein
    J G Jacobs
    Central Veterinary Institute of Wageningen UR CVI, P O Box 65, 8200 AB Lelystad, The Netherlands
    J Virol 85:12537-46. 2011
    Classical scrapie is a prion disease in sheep and goats. In sheep, susceptibility to disease is genetically influenced by single amino acid substitutions...
  89. pmc A missense mutation in growth differentiation factor 9 (GDF9) is strongly associated with litter size in sheep
    Dag I Vage
    Centre for Integrative Genetics CIGENE, Department of Animal and Aquacultural Sciences IHA, Norwegian University of Life Sciences UMB, PO Box 5003, N 1432 As, Norway
    BMC Genet 14:1. 2013
    A genome wide association study for litter size in Norwegian White Sheep (NWS) was conducted using the recently developed ovine 50K SNP chip from Illumina...
  90. doi Long-term defaunation increases the abundance of cellulolytic ruminococci and methanogens but does not affect the bacterial and methanogen diversity in the rumen of sheep
    P Mosoni
    INRA, UR454 Microbiologie, F 63122 Saint Genes Champanelle, France
    J Anim Sci 89:783-91. 2011
    ..The trial was conducted in 5 adult sheep subjected successively to long-term defaunation (2 yr), refaunation (12 wk), and short-term defaunation (10 wk)...
  91. pmc Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep
    Noah H Hillman
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, OH 45236, USA
    Respir Res 11:151. 2010
    ..Increased pro-inflammatory cytokines in tracheal aspirates correlate with the development of BPD in preterm infants. Ventilation of preterm lambs increases pro-inflammatory cytokines and causes lung inflammation...
  92. doi Horn type and horn length genes map to the same chromosomal region in Soay sheep
    S E Johnston
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK
    Heredity (Edinb) 104:196-205. 2010
    ..Soay sheep have an inherited polymorphism for horn type in both sexes, with males presenting with either large, normal horns ..
  93. pmc Genetic characterizations of Giardia duodenalis in sheep and goats in Heilongjiang Province, China and possibility of zoonotic transmission
    Weizhe Zhang
    Department of Parasitology, Harbin Medical University, Harbin, People s Republic of China
    PLoS Negl Trop Dis 6:e1826. 2012
    ..duodenalis of animal origin is unclear. No information about occurrence and genotyping data of sheep and goat giardiasis is available in China...
  94. doi The effect of repeated testing on judgement biases in sheep
    Rebecca E Doyle
    CSIRO Livestock Industries, New England Highway, Armidale, NSW 2350, Australia
    Behav Processes 83:349-52. 2010
    ..This experiment investigated the effect of repeated testing using unreinforced, ambiguous cues on the response of sheep to a go/no-go judgement bias test...
  95. ncbi Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases
    S A Moore
    Institute of Molecular Biosciences, Massey University, Private Bag, 11 222, Palmerston North, New Zealand
    Structure 6:1541-51. 1998
    ..Thus, ALDH1 is very likely to have a key role in vertebrate development...
  96. doi Anaplasma phagocytophilum variants in sympatric red deer (Cervus elaphus) and sheep in southern Norway
    Snorre Stuen
    Norwegian School of Veterinary Science, Department of Production Animal Clinical Sciences, Sandnes, Norway
    Ticks Tick Borne Dis 4:197-201. 2013
    ..red deer (Cervus elaphus) are infective in lambs, but epidemiological links between infections in red deer and sheep have yet to be established...
  97. pmc Multilocus sequence analysis provides insights into molecular epidemiology of Chlamydia pecorum infections in Australian sheep, cattle, and koalas
    Martina Jelocnik
    Institute for Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia
    J Clin Microbiol 51:2625-32. 2013
    ..sequence analysis (MLSA) scheme to examine the genetic diversity of and relationships between Australian sheep, cattle, and koala isolates...
  98. pmc The pregnant sheep as a model for human pregnancy
    J S Barry
    Perinatal Research Facility, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045 0508, USA
    Theriogenology 69:55-67. 2008
    ..No animal model truly recapitulates human pregnancy, yet the pregnant sheep has been used extensively to investigate maternal-fetal interactions...
  99. doi Placental restriction reduces insulin sensitivity and expression of insulin signaling and glucose transporter genes in skeletal muscle, but not liver, in young sheep
    Miles J De Blasio
    The Robinson Institute and School of Pediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia 5005, Australia
    Endocrinology 153:2142-51. 2012
    ..Onset of insulin resistance after PR and IUGR is accompanied by, and can be accounted for by, reduced expression of insulin signaling and metabolic genes in skeletal muscle but not liver...
  100. pmc DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status
    Kevin D Sinclair
    School of Biosciences and School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, United Kingdom
    Proc Natl Acad Sci U S A 104:19351-6. 2007
    ..and folate) and methionine, within normal physiological ranges, from the periconceptional diet of mature female sheep. We hypothesized this would lead to epigenetic modifications to DNA methylation in the preovulatory oocyte and/or ..
  101. ncbi Are cattle, sheep, and goats endangered species?
    P Taberlet
    Laboratoire d Ecologie Alpine, CNRS UMR 5553, Universite Joseph Fourier, BP 53, 38041 Grenoble Cedex 09, France
    Mol Ecol 17:275-84. 2008
    For about 10 000 years, farmers have been managing cattle, sheep, and goats in a sustainable way, leading to animals that are well adapted to the local conditions...

Research Grants74

  1. The Primate Corpus Luteum: Functional Regression and Cardiovascular Impacts
    Randy L Bogan; Fiscal Year: 2012
    ..Dr. Bogan's graduate research utilized sheep as an experimental model to study mechanisms controlling the synthesis of progesterone (P4) by the corpus luteum (..
  2. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2013
    ..My preliminary data indicate that chloroquine: 1- terminates cholinergic AF in the isolated sheep heart;2- impedes ion movement through the channel's vestibule by interacting with specific amino acid ..
  3. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..My preliminary data indicate that chloroquine: 1- terminates cholinergic AF in the isolated sheep heart;2- impedes ion movement through the channel's vestibule by interacting with specific amino acid ..
  4. Novel Therapy for Preeclampsia
    James W Larrick; Fiscal Year: 2012
    ..Digibind (GlaxoSmithKline) is a commercially available anti-digoxin sheep polyclonal antibody approved for the treatment of digoxin overdose. Digibind cross-reacts with MBG and other CTS...
  5. Maternal nutrient restriction and nonhuman primate fetal skeletal muscle developm
    Min Du; Fiscal Year: 2010
    ..Underlying mechanisms remain undefined. RATIONALE: Sheep and rat studies indicate that FNR affects fetal skeletal muscle (SM) development with long-lasting effects on ..
  6. Resuscitation of smoke inhalation and burn injury with a thioredoxin mimetic
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..randomized, double-blinded, study in which respiratory insufficiency is induced in mechanically-ventilated Merino sheep by acute SIBI...
  7. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..The vessels will then be implanted as interposition grafts in the carotid arteries of living sheep, and will be imaged in 500[unreadable]m resolution to follow the tissue regeneration and function...
  8. The unique role of B-Raf in murine cardiac development and postnatal function
    Natasha N Chattergoon; Fiscal Year: 2013
    ..I have invested the several years required to become facile with the fetal sheep model used in Dr. Thornburg's laboratory. With that came extensive teaching by our collaborators, Drs...
  9. Role of Selectins in Burns and Inhalation Injury
    Daniel Traber; Fiscal Year: 2009
    ..ARDS is associated with organ system failure(MODS). This proposal models ARDS and MODS in a sheep that has a 40% 3rd degree burn with smoke inhalation injury...
  10. Effect of Prone Position on Ventilator-Induced Lung Injury
    Guido Musch; Fiscal Year: 2013
    ..This hypothesis will be examined in a large animal with physiology similar to the human (i.e., sheep), in three specific aims...
  11. Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigen
    Ana M Espino; Fiscal Year: 2013
    ..Fasciola hepatica causes liver fluke disease or fascioliasis, thereby affecting the health of humans, as well as sheep, cattle and goats, among others mammalians. Fascioliasis causes losses in agriculture estimated at >US3...
  12. (INTRODUCTION) MECHANISMS OF ACCLIMATIZATION: FETUS AND ADULT
    Lawrence D Longo; Fiscal Year: 2013
    ..Based on >21 years of research by our group, studies will be conducted in sheep acclimatized to high altitude (3801 m/12,470 ft). We shall test a number of hypotheses...
  13. Molecular Biology of Eukaryotic Viruses
    Bert L Semler; Fiscal Year: 2012
    ..The viruses/viral systems being studied include murine leukemia virus, a sheep retrovirus (JSRV), HIV, yeast Ty3, poliovirus, human rhinovirus, coxsackievirus, mouse hepatitis virus, SARS ..
  14. Platelet-Derived FVIII Gene Therapy of Hemophilia A
    Qizhen Shi; Fiscal Year: 2013
    ..sufficient platelet-FVIII expression and rescue the hemorrhagic phenotype in hemophilic mice and hemophilic sheep with inhibitors...
  15. Impact of Catecholamines to Insulin-Glucose Homeostasis in IUGR Fetuses
    Sean W Limesand; Fiscal Year: 2013
    ..chronic catecholamine stimulation (coupled with hypoxia and hypoglycemia) modulates insulin secretion in fetal sheep with placental insufficiency, a model system that shares many similarities to human IUGR fetuses with placental ..
  16. SYNTHESES AND CELLULAR STUDIES OF NEW PHOTOSENSITIZERS FOR MEDICAL APPLICATIONS
    Kevin M Smith; Fiscal Year: 2013
    ..from blood, bone marrow purging, and for inhibition of transmissible spongiform encephalopathies [bovine (BSE), sheep (scrapie) and human forms (Creutzfeld-Jacob disease)]...
  17. Role of Fetal Steroids in Formation and Activation of Bovine Ovarian Follicles
    Joanne E Fortune; Fiscal Year: 2010
    ..In cattle, sheep, and other large mammals, including humans, primordial follicles form over a number of weeks during fetal life, in ..
  18. Sulfotransferases in the Synthesis of L-Selectin Ligands
    Steven D Rosen; Fiscal Year: 2010
    ..g., anti TNF-1 therapy), our work may lead to new approaches for the treatment of RA. We will also investigate a sheep model of asthma in which L-selectin appears to play a highly novel role (Aim 3)...
  19. Biomaterials (Mf/Zn/F-BCPs) for osteoporosis therapy
    Yu Zhang; Fiscal Year: 2012
    ..D supplement;(3) evaluate the effect of MZF-CaP and MZ-CaP/FF on prevention of bone loss in a larger animal model (sheep);and (4) determine the effects of MZF-CaPs and MZ-CaP/FF on the following levels: (a) molecular (gene expression) ..
  20. Augmentation of Innate Anti-Microbial Immunity by TLR4 Agonists
    Edward R Sherwood; Fiscal Year: 2013
    ..This aim will test the hypothesis that MPLA will be well tolerated in burned sheep and will improve their response to wound infection and pneumonia...
  21. A novel model for studying fetal skeletal muscle development
    Min Du; Fiscal Year: 2009
    ..Pregnant sheep carrying these fetuses will be allowed to lamb which will then be euthanized for muscle collection...
  22. Preventing Human Prion Diseases - Inactivation of Prions
    Stanley B Prusiner; Fiscal Year: 2010
    ..Initially, we plan to study three strains of prions passaged in mice: RML and 301V, which originated from sheep with scrapie and cattle with BSE, respectively, plus a novel synthetic strain MoSP1, which is the most stable ..
  23. Intrauterine chronic hypoxia and ryanodine receptors in fetal pulmonary arteries
    Sean M Wilson; Fiscal Year: 2013
    ..Gestation at high altitude causes a variety of pulmonary vascular malformations in fetal sheep including suppressed endothelium dependent relaxation, altered myocyte growth, and reactivity that place them at ..
  24. Impact of Microparticles on Oral TSE Infections
    Joel A Pedersen; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Prion diseases are transmissible neurologic disorders that can affect animals (sheep scrapie, cervid chronic wasting disease, bovine spongiform encephalopathy) and humans (Creutzfeldt-Jakob disease ..
  25. TISSUE SPECIFIC REGULATION OF GLUCOSE METABOLISM AND INSULIN ACTION IN IUGR FETUS
    Stephanie R Thorn; Fiscal Year: 2013
    ..which are normally absent during fetal life, are strikingly up-regulated in the late gestation IUGR fetal sheep. Our data also indicate that insulin fails to suppress glucose production in the IUGR fetus, yet robustly ..
  26. Nutrient Restriction: Placental and Fetal Brain and Renal Outcomes and Mechanism
    Peter W Nathanielsz; Fiscal Year: 2012
    ..Whilst primary causes are diverse, poor F development is generally secondary to F NR. Rodent and sheep studies provide insight but parallel nonhuman primate (NHP) data are minimal...
  27. Physiological Mechanisms Underlying Heightened Responsiveness of Gonadotropes to
    Colin M Clay; Fiscal Year: 2013
    ..responsive phenotype does not;however, appear to involve direct binding of activated estrogen receptor (ER) to the sheep gene...
  28. Development of a Novel Rift Valley Fever Virus Vaccine
    Shinji Makino; Fiscal Year: 2013
    ..endemic disease of sub-Saharan Africa that can emerge in explosive mosquito-borne epidemics, decimating herds of sheep and cattle and resulting in enormous economic losses;humans are infected concurrently, and their infection results ..
  29. Crystalline hydroxocobalamin and methemoglobin as a treatment of H2S intoxication
    PHILIPPE A HAOUZI; Fiscal Year: 2013
    ..rodents) a specific protective response, not found in larger mammals, we intend to conduct our studies in adult sheep. In this proposal, we will determine the ability of these antidotes to lower the concentration of H2S, and its ..
  30. Effects of maternal cortisol on fetal and neonatal growth and metabolism
    Maureen Keller-Wood; Fiscal Year: 2013
    ..In these studies we will use pregnant sheep in late gestation to test several hypotheses relating to effects of maternal cortisol on fetal growth and on ..
  31. Bisphenol-A and Reproductive Dysfunction
    Vasantha Padmanabhan; Fiscal Year: 2013
    ..Our preliminary studies using sheep as a model revealed that prenatal exposure to the plasticizer bisphenol A (BPA), an environmentally relevant EDC, ..
  32. Actions of Estrogen on Uterine Artery Endothelium
    DongBao Chen; Fiscal Year: 2010
    ..Five specific aims will be studied by using the well-defined sheep uterine artery endothelial cell culture model and human umbilical cord vein endothelial cells...
  33. Pre-Clinical Development of a Fetal Micropacemaker
    Ramen Chmait; Fiscal Year: 2013
    ..next translational step of the project requires the successful implantation of a functional device into a fetal sheep to demonstrate proof of concept in a relevant pre-clinical animal model...
  34. Structure and assembly of the fungal prion HET-s
    William N Wan; Fiscal Year: 2013
    ..TSEs include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in deer and elk, and several ..
  35. Targeted genome modification of guinea pig and sheep using engineered zinc finger
    Hilda Holcombe; Fiscal Year: 2011
    ..rodent and one non-rodent, to demonstrate proof of concept and to generate genetically modified guinea pigs and sheep that are valuable models for human diseases...
  36. Cortisol regulation of perinatal adipose tissue and sheep neonatal leptin peak
    Stephen P Ford; Fiscal Year: 2013
    ..No comprehensive studies on neonatal leptin exist in precocial species, humans or important farm animals. Our sheep model of diet-induced maternal obesity (MO) increases adult OFF appetite and adiposity...
  37. FT-IR Microscopy of Mineral Structure
    Adele L Boskey; Fiscal Year: 2013
    ..This will be tested by analyses of pre- and post- treatment human biopsies and by analyses in a sheep model. 4) XLR, which is altered in osteoporosis, is related to collagen orientation...
  38. Installation of Energy-Efficient Cage Washers for Childrens Hospital Vivarium
    Philip R Johnson; Fiscal Year: 2012
    ..The vivarium houses both large animal species (dogs, pigs, sheep, and rabbits) and CHOP's rodent quarantine facility...
  39. Liposome-siRNA-Peptide Complexes as Therapy to Cure Prion Diseases in Mouse Model
    Mark D Zabel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Transmissible spongiform encephalopathies (TSEs) include scrapie in sheep;bovine spongiform encephalopathy (BSE) in cattle;chronic wasting disease (CWD) in deer and elk;and Kuru and Creutzfeldt-Jakob ..
  40. Development of High Affinity Analogues of Brevenal: Novel Molecular Probes for Ne
    Mary C Wolf; Fiscal Year: 2011
    ..In sheep inhalation models, brevenal blocks PbTx-induced bronchoconstriction and leads to increased tracheal mucous ..
  41. Hypoxia and Aberrant Uterine Vascular Adaptation in Pregnancy
    Lubo Zhang; Fiscal Year: 2013
    ..Recent studies in sheep have demonstrated that chronic hypoxia during gestation causes a significant decrease in estrogen receptor 1 (ER1) ..
  42. STUDIES OF UTEROPLACENTAL CIRCULATION
    CHARLES RICHARD ROSENFELD; Fiscal Year: 2013
    ..g., diabetes. To address these questions, we will study chronically instrumented nonpregnant, pregnant and fetal sheep, which provide physiologic data and observations that can be explained by parallel studies of biochemical, ..
  43. Biocompatibility of Implantable Renal Replacement Devices
    Shuvo Roy; Fiscal Year: 2013
    ..techniques, and short-term implantable hemofiltration in rodents and pigs as well as wearable cell therapy in sheep. We also identified a number of critical roadblocks to successful development of implantable bioartificial kidney...
  44. Cellular and molecular mechanisms of preterm white matter injury
    Art Riddle; Fiscal Year: 2013
    ..To achieve these objectives an in utero preparation in the 0.65 gestation sheep will be utilized in which ischemia will be induced in fetuses through the inflation of occluders placed on the ..
  45. Interactions of dynorphin, NKB, and kisspeptin in control of GnRH secretion
    Michael N Lehman; Fiscal Year: 2013
    ..These questions will be addressed using the female sheep, a model that possesses several unique advantages including the ability to directly monitor GnRH in hypophysial ..
  46. Prenatal Events-Postnatal Consequences
    James C Rose; Fiscal Year: 2013
    ..During the past five years we have studied the programming effects of antenatal steroid therapy in a widely used sheep model and in a cohort of adolescents...
  47. Serum microRNAs as biomarkers of post-traumatic osteoarthritis
    Gary J Gibson; Fiscal Year: 2010
    ..will then be conducted in two distinct models of PTOA;a much larger group of patients with ACL injury and a sheep model of PTOA, mimicking human PTOA resulting from impact trauma...
  48. Endogenous Retroviruses and Placental Morphogenesis
    Thomas E Spencer; Fiscal Year: 2011
    ..betaretoviruses during the peri-implantation period of conceptus development and placental morphogenesis in sheep. Sheep harbor endogenous betaretroviruses (termed endogenous Jaagsiekte Sheep Retroviruses or enJSRVs) that are ..
  49. One Health Innovation Fellowships for Zoonotic Disease Research In Mongolia
    GREGORY CHARLES GRAY; Fiscal Year: 2013
    ..economy in 1992, Mongolia has undergone rapid change with increases in mining operations and animal production of sheep, goats, and cattle...
  50. Isolation, Identification and Characterization of a Toxin Causing Biliary Atresia
    Rebecca G Wells; Fiscal Year: 2013
    ..of BA in newborn livestock in Australia associated with ingestion of the plant Dysphania glomulifera by pregnant sheep and cows...
  51. Targeted genome modification of guinea pig and sheep using engineered zinc finger
    Hilda Holcombe; Fiscal Year: 2012
    ..rodent and one non-rodent, to demonstrate proof of concept and to generate genetically modified guinea pigs and sheep that are valuable models for human diseases...
  52. Characteristics of Prion Entry and Neuroinvasion Following Nasal Cavity Infection
    Anthony E Kincaid; Fiscal Year: 2013
    ..spread of prion disease between animals, such as chronic wasting disease in deer and elk, and scrapie in sheep and goats...
  53. Role of nitrite and hemoglobin in vascular NO homeostasis in the fetus and adult
    Arlin B Blood; Fiscal Year: 2013
    ..The first will use chronically instrumented near-term fetal sheep to determine the effects of circulating nitrite on the fetal cardiovasculature and oxygen consumption, and whether ..
  54. Genes contributing to patent ductus arteriosus susceptibility in preterm newborns
    Ronald I Clyman; Fiscal Year: 2013
    ..In this proposal, we will extend our previous work (performed in mice, sheep, and baboons) to the human ductus and identify molecular pathways that are altered in premature human ductus that ..
  55. EFFECTS OF INHALED FLORIDA RED TIDE BREVETOXINS
    Daniel G Baden; Fiscal Year: 2011
    ..Research Project 3 "Mechanism of PbTx-lnduced Responses" explores inhaled effects in a sheep model, including inflammation, mucociliary clearance, therapeutics and prevention...
  56. Identifying components of Toxoplasma oocysts that confer environmental resistance
    HEATHER MICHELLE FRITZ; Fiscal Year: 2013
    ..g. swine, cattle, sheep) containing bradyzoite tissue cysts, or through congenital transmission...
  57. Late Preterm Birth, Ureaplasma Species and Childhood Lung Disease
    Suhas Kallapur; Fiscal Year: 2012
    ..parvum chorioamnionitis in fetal sheep. The clinical study will select cohorts of late preterm infants based on cultures for Ureaplasma spp, and ..
  58. Perfluorooctane Sulfonate (PFOS) affects 1gM Production via IL-2
    Margie M Peden Adams; Fiscal Year: 2010
    ..IL-1 and IL-10, and CD25, CD27, and CD70 expression in the suppression of antibody production by PFOS in sheep red blood cell challenged (activated) immune cells The unimmunized and immunized experiments will be conducted to ..
  59. Thyroid regulation of cardiomyocyte maturation
    KENT L R THORNBURG; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In fetal sheep, cardiomyocytes gradually cease dividing and become binucleated (terminal differentiation) at ~100 days of a 145 day gestational period...
  60. Translational Studies of FASD Using a Sheep Model-U01
    Shannon E Washburn; Fiscal Year: 2011
    ..Animal models are essential to those goals. This project proposes a novel sheep model that is especially well suited for experimental translational studies of FASD...
  61. "New Needle for Two-Needle Hemodialysis"
    ALFREDO R ZARATE; Fiscal Year: 2011
    ..c) More importantly, the data from HD in sheep and patients suggest that the NVN is clinically superior to the CVN because it causes less damage to circulating ..
  62. IN UTERO STEM CELL TRANSPLANTATION
    Esmail Zanjani; Fiscal Year: 2011
    ..will enable achievement of therapeutic levels of HSC engraftment following IUSCT and cure a clinically relevant sheep model of a lysosomal storage disease...
  63. Anti-fibrotic Coatings for Rapidly Exchangeable Bioprosthetic Heart Valve
    Ivan Vesely; Fiscal Year: 2010
    ..second, VXI investigated the ability of anti-adhesion coatings to abate fibrotic overgrowth in the hyper-fibrotic sheep model...
  64. THE EFFECTS OF COCAINE ON FETAL OXYGENATION
    James Woods; Fiscal Year: 1993
    ..laboratory suggest that intravenous cocaine produces greater systemic responses in the pregnant than nonpregnant sheep which are accompanied by reduced uterine blood flow and fetal oxygen levels...
  65. Exchangeable Heart Valve for Tissue Engineering Applications
    Ivan Vesely; Fiscal Year: 2007
    ..Progress in this field has been hampered by the cost of the experimental model - the juvenile sheep that has a tissue-engineered valve implanted in the aortic position...
  66. LUNG FUNCTION IN PROLONGED HEART FAILURE
    Marie Francoise Doursout; Fiscal Year: 2004
    ..The first specific aim is to test if lung connective tissue is increased and late phase edema occurs in a sheep model of elevated Pc...
  67. Characterization of de novo generation of infectious prions
    Joaquin Castilla; Fiscal Year: 2009
    ..e. Bovine spongiform encephalopathy (BSE) in US cattle and Nor98 (atypical scrapie) in New Zealand sheep, provide evidence that this infrequent spontaneous phenomenon may occur naturally...
  68. RENAL FUNCTION AND BLOOD PRESSURE CONTROL IN PREGNANCY
    Edmond Quillen; Fiscal Year: 2000
    ..These studies will be conducted in vivo using non- pregnant and pregnant sheep, and then supplemented with a number of cellular and molecular approaches to further define mechanisms of action...
  69. Assessing the Transmissibility of CWD to Humans
    Qingzhong Kong; Fiscal Year: 2010
    ..to humans directly (Aim 1)? Can CWD be transmitted to humans after passage through secondary hosts (cattle or sheep) (Aim 2)? Has CWD transmission to humans already occurred (Aim 3)? The ultimate goals are to define the risks of ..
  70. MECHANISMS OF HYPOXIC CEREBRAL VASODILATATION IN NEWBORN
    William Pearce; Fiscal Year: 1992
    ..carotid, basilar, posterior communicating, and rostral choroidal arteries taken from 3-7 day old lambs and adult sheep. Three main hypotheses will be examined...
  71. Engineered Multi-Functional Nanofibrous Meniscus Implants
    John Esterhai; Fiscal Year: 2009
    ..Next, scaffolds will be formed into anatomic shapes, and used to repair subtotal meniscectomies in a sheep model...
  72. Endocrine Disruptors and Fetal Development
    Vasantha Padmanabhan; Fiscal Year: 2010
    ..Our preliminary studies using sheep as a model revealed that prenatal exposure to the plasticizer bisphenol A (BPA), an environmentally pervasive ..
  73. Paracorporeal Artificial Lung Development
    Scott Merz; Fiscal Year: 2001
    ..UTMB) in a pulmonary artery-to-pulmonary artery (PA-PA) configuration, and supported gas exchange in normal sheep (N=8) for up to 7 days...
  74. SYSTEMIC AND LOCAL REGULATION OF MYOMETRIAL ACTIVITY
    Jorge Figueroa; Fiscal Year: 1993
    ..the sympathoadrenal system (SAS), prostaglandins (PG) and oxytocin (OT) in regulating myometrial activity in sheep. I will study these interactive factors in non pregnant ewes and pregnant ewes both before and during labor...