cattle

Summary

Summary: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

Articles from Journal RESEARCH

Top Publications

  1. pmc A whole-genome assembly of the domestic cow, Bos taurus
    Aleksey V Zimin
    Institute for Physical Science and Technology, University of Maryland, College Park, Maryland 20742, USA
    Genome Biol 10:R42. 2009
  2. pmc Development and characterization of a high density SNP genotyping assay for cattle
    Lakshmi K Matukumalli
    Department of Bioinformatics and Computational Biology, George Mason University, Manassas, Virginia, United States of America
    PLoS ONE 4:e5350. 2009
  3. ncbi Invited review: Genomic selection in dairy cattle: progress and challenges
    B J Hayes
    Department of Primary Industries Victoria, Biosciences Research Division, Bundoora, Australia
    J Dairy Sci 92:433-43. 2009
  4. ncbi Invited review: reliability of genomic predictions for North American Holstein bulls
    P M Vanraden
    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705 2350, USA
    J Dairy Sci 92:16-24. 2009
  5. ncbi Efficient methods to compute genomic predictions
    P M Vanraden
    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705 2350, USA
    J Dairy Sci 91:4414-23. 2008
  6. pmc Novel orthobunyavirus in Cattle, Europe, 2011
    Bernd Hoffmann
    Friedrich Loeffl er Institut, Greifswald Insel Riems, Germany
    Emerg Infect Dis 18:469-72. 2012
  7. ncbi Metagenomic discovery of biomass-degrading genes and genomes from cow rumen
    Matthias Hess
    Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USA
    Science 331:463-7. 2011
  8. pmc Re-evaluating the burden of rabies in Africa and Asia
    Darryn L Knobel
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, Scotland
    Bull World Health Organ 83:360-8. 2005
  9. ncbi Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature
    Latifa Karim
    Unit of Animal Genomics, Interdisciplinary Institute of Applied Genomics GIGA R and Faculty of Veterinary Medicine, University of Liège B34, Liege, Belgium
    Nat Genet 43:405-13. 2011
  10. ncbi Cellular motility driven by assembly and disassembly of actin filaments
    Thomas D Pollard
    Department of Cellular, Molecular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 112:453-65. 2003

Detail Information

Articles from Journal RESEARCH1

Publications278 found, 100 shown here

  1. pmc A whole-genome assembly of the domestic cow, Bos taurus
    Aleksey V Zimin
    Institute for Physical Science and Technology, University of Maryland, College Park, Maryland 20742, USA
    Genome Biol 10:R42. 2009
    ..The genome of the domestic cow, Bos taurus, was sequenced using a mixture of hierarchical and whole-genome shotgun sequencing methods...
  2. pmc Development and characterization of a high density SNP genotyping assay for cattle
    Lakshmi K Matukumalli
    Department of Bioinformatics and Computational Biology, George Mason University, Manassas, Virginia, United States of America
    PLoS ONE 4:e5350. 2009
    ..for the development of a custom genotyping assay interrogating 54,001 SNP loci to support GWA applications in cattle is described...
  3. ncbi Invited review: Genomic selection in dairy cattle: progress and challenges
    B J Hayes
    Department of Primary Industries Victoria, Biosciences Research Division, Bundoora, Australia
    J Dairy Sci 92:433-43. 2009
    A new technology called genomic selection is revolutionizing dairy cattle breeding. Genomic selection refers to selection decisions based on genomic breeding values (GEBV)...
  4. ncbi Invited review: reliability of genomic predictions for North American Holstein bulls
    P M Vanraden
    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705 2350, USA
    J Dairy Sci 92:16-24. 2009
    ..Reliability increased more by doubling the number of bulls genotyped than the number of markers genotyped. Genomic prediction improves reliability by tracing the inheritance of genes even with small effects...
  5. ncbi Efficient methods to compute genomic predictions
    P M Vanraden
    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705 2350, USA
    J Dairy Sci 91:4414-23. 2008
    ..Actual gains may differ because the simulation did not account for linkage disequilibrium in the base population or selection in subsequent generations...
  6. pmc Novel orthobunyavirus in Cattle, Europe, 2011
    Bernd Hoffmann
    Friedrich Loeffl er Institut, Greifswald Insel Riems, Germany
    Emerg Infect Dis 18:469-72. 2012
    In 2011, an unidentified disease in cattle was reported in Germany and the Netherlands. Clinical signs included fever, decreased milk production, and diarrhea...
  7. ncbi Metagenomic discovery of biomass-degrading genes and genomes from cow rumen
    Matthias Hess
    Department of Energy, Joint Genome Institute, Walnut Creek, CA 94598, USA
    Science 331:463-7. 2011
    ..These data sets provide a substantially expanded catalog of genes and genomes participating in the deconstruction of cellulosic biomass...
  8. pmc Re-evaluating the burden of rabies in Africa and Asia
    Darryn L Knobel
    Centre for Tropical Veterinary Medicine, Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, Scotland
    Bull World Health Organ 83:360-8. 2005
    ..To quantify the public health and economic burden of endemic canine rabies in Africa and Asia...
  9. ncbi Variants modulating the expression of a chromosome domain encompassing PLAG1 influence bovine stature
    Latifa Karim
    Unit of Animal Genomics, Interdisciplinary Institute of Applied Genomics GIGA R and Faculty of Veterinary Medicine, University of Liège B34, Liege, Belgium
    Nat Genet 43:405-13. 2011
    ..By performing expression QTL analyses, we identified a splice site variant in CHCHD7 and exploited this naturally occurring null allele to exclude CHCHD7 as single causative gene...
  10. ncbi Cellular motility driven by assembly and disassembly of actin filaments
    Thomas D Pollard
    Department of Cellular, Molecular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 112:453-65. 2003
    ..Profilin catalyzes the exchange of ADP for ATP, refilling the pool of ATP-actin monomers bound to profilin, ready for elongation...
  11. ncbi CpG islands in vertebrate genomes
    M Gardiner-Garden
    Kanematsu Laboratories, Royal Prince Alfred Hospital, Camperdown N S W, Australia
    J Mol Biol 196:261-82. 1987
    ..Possible functions of CpG islands in transcriptional and post-transcriptional regulation of gene expression were discussed, and were related to theories for the maintenance of CpG islands as "methylation-free zones" in germline DNA...
  12. pmc Gene-centric metagenomics of the fiber-adherent bovine rumen microbiome reveals forage specific glycoside hydrolases
    Jennifer M Brulc
    Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 106:1948-53. 2009
    ....
  13. pmc Extension of the bayesian alphabet for genomic selection
    David Habier
    Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, IA 50011, USA
    BMC Bioinformatics 12:186. 2011
    ..The methods were compared in terms of inference of the number of QTL and accuracy of genomic estimated breeding values (GEBVs), using simulated scenarios and real data from North American Holstein bulls...
  14. pmc Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study
    Laura García-Álvarez
    Department of Veterinary Medicine, University of Cambridge, UK
    Lancet Infect Dis 11:595-603. 2011
    ....
  15. pmc Seroprevalence of Schmallenberg virus antibodies among dairy cattle, the Netherlands, winter 2011-2012
    Armin R W Elbers
    Department of Epidemiology, Crisis organisation and Diagnostics, Central Veterinary Institute, part of Wageningen UR, Lelystad, The Netherlands
    Emerg Infect Dis 18:1065-71. 2012
    ..of infection, we conducted a seroprevalence study in the Netherlands to detect past exposure to SBV among dairy cattle. A total of 1,123 serum samples collected from cattle during November 2011-January 2012 were tested for antibodies ..
  16. pmc Copy number variation of individual cattle genomes using next-generation sequencing
    Derek M Bickhart
    USDA ARS, ANRI, Bovine Functional Genomics Laboratory, Beltsville, Maryland 20705, USA
    Genome Res 22:778-90. 2012
    ..copy number differences among five taurine (three Angus, one Holstein, and one Hereford) and one indicine (Nelore) cattle. Within mapped chromosomal sequence, we identified 1265 CNV regions comprising ~55...
  17. pmc Genomic characteristics of cattle copy number variations
    Yali Hou
    Bovine Functional Genomics Laboratory, ANRI, USDA ARS, Beltsville, Maryland 20705, USA
    BMC Genomics 12:127. 2011
    ..In the dairy industry, a large quantity of SNP genotyping results are becoming available and can be used for CNV discovery to understand and accelerate genetic improvement for complex traits...
  18. pmc Dynamical patterns of cattle trade movements
    Paolo Bajardi
    Computational Epidemiology Laboratory, Institute for Scientific Interchange, Torino, Italy
    PLoS ONE 6:e19869. 2011
    ..network science approach, here we are able for the first time to fully analyze the longitudinal dataset of Italian cattle movements that reports the mobility of individual animals among farms on a daily basis...
  19. pmc Double muscling in cattle due to mutations in the myostatin gene
    A C McPherron
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 94:12457-61. 1997
    ..and the identification of mutations in the coding sequence of bovine myostatin in two breeds of double-muscled cattle, Belgian Blue and Piedmontese, which are known to have an increase in muscle mass relative to conventional cattle...
  20. pmc Evaluation of the bacterial diversity in the feces of cattle using 16S rDNA bacterial tag-encoded FLX amplicon pyrosequencing (bTEFAP)
    Scot E Dowd
    USDA ARS Livestock Issues Research Unit, Lubbock, TX 79403, USA
    BMC Microbiol 8:125. 2008
    ..There is still a scarcity of information on the microbial diversity in the gut of livestock species such as cattle. The primary reason for this lack of data relates to the expense of methods needed to generate such data...
  21. ncbi A deletion in the bovine myostatin gene causes the double-muscled phenotype in cattle
    L Grobet
    Department of Genetics, Faculty of Veterinary Medicine, University of Liege, Belgium
    Nat Genet 17:71-4. 1997
    An exceptional muscle development commonly referred to as 'double-muscled' (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers...
  22. pmc Analysis of copy number variations among diverse cattle breeds
    George E Liu
    USDA ARS, ANRI, Bovine Functional Genomics Laboratory, Beltsville, Maryland 20705, USA
    Genome Res 20:693-703. 2010
    ..we describe the first systematic and genome-wide analysis of copy number variations (CNVs) in modern domesticated cattle using array comparative genomic hybridization (array CGH), quantitative PCR (qPCR), and fluorescent in situ ..
  23. ncbi The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
    R Rohatgi
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 97:221-31. 1999
    ..Therefore, N-WASP and the Arp2/3 complex comprise a core mechanism that directly connects signal transduction pathways to the stimulation of actin polymerization...
  24. ncbi Improving accuracy of genomic predictions within and between dairy cattle breeds with imputed high-density single nucleotide polymorphism panels
    M Erbe
    Department of Animal Sciences, Animal Breeding and Genetics Group, Georg August University Gottingen, 37075 Gottingen, Germany
    J Dairy Sci 95:4114-29. 2012
    Achieving accurate genomic estimated breeding values for dairy cattle requires a very large reference population of genotyped and phenotyped individuals...
  25. ncbi The public health significance and control of schistosomiasis in China--then and now
    Xiao Nong Zhou
    National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China
    Acta Trop 96:97-105. 2005
    ..Finally, we discuss remaining challenges for schistosomiasis control with the ultimate goal of disease elimination...
  26. pmc Recent human-to-poultry host jump, adaptation, and pandemic spread of Staphylococcus aureus
    Bethan V Lowder
    The Roslin Institute and Centre for Infectious Diseases, Royal Dick School of Veterinary Studies, Queens Medical Research Institute, University of Edinburgh, Edinburgh EH8 9YL, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 106:19545-50. 2009
    ..These data provide a new paradigm for the impact of human activities on the emergence of animal pathogens...
  27. ncbi Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle
    R Kambadur
    AgResearch, Ruakura, Hamilton, New Zealand
    Genome Res 7:910-6. 1997
    ..mh), commonly known as double muscling, occurs with high frequency in the Belgian Blue and Piedmontese cattle breeds...
  28. pmc A deletion in the bovine FANCI gene compromises fertility by causing fetal death and brachyspina
    Carole Charlier
    Unit of Animal Genomics, GIGA R and Faculty of Veterinary Medicine, University of Liège B34, Liege, Belgium
    PLoS ONE 7:e43085. 2012
    Fertility is one of the most important traits in dairy cattle, and has been steadily declining over the last decades...
  29. pmc Genetic architecture of complex traits and accuracy of genomic prediction: coat colour, milk-fat percentage, and type in Holstein cattle as contrasting model traits
    Ben J Hayes
    Biosciences Research Division, Department of Primary Industries Victoria, Melbourne, Victoria, Australia
    PLoS Genet 6:e1001139. 2010
    ..Proportion of black coat colour in Holstein cattle was used as one model complex trait...
  30. pmc Genome-wide association study identified three major QTL for carcass weight including the PLAG1-CHCHD7 QTN for stature in Japanese Black cattle
    Shota Nishimura
    Shirakawa Institute of Animal Genetics, Japan Livestock Technology Association, Odakura, Nishigo, Fukushima, 961 8061, Japan
    BMC Genet 13:40. 2012
    ..Recent advances in genomic tools allowed us to perform a genome-wide association study (GWAS) in cattle to detect associations in a general population and estimate their effect size...
  31. pmc Genomic evaluations with many more genotypes
    Paul M Vanraden
    Animal Improvement Programs Laboratory, USDA, Building 5 BARC West, Beltsville, MD 20705 2350, USA
    Genet Sel Evol 43:10. 2011
    Genomic evaluations in Holstein dairy cattle have quickly become more reliable over the last two years in many countries as more animals have been genotyped for 50,000 markers...
  32. ncbi The genomic evaluation system in the United States: past, present, future
    G R Wiggans
    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, MD 20705 2350, USA
    J Dairy Sci 94:3202-11. 2011
    Implementation of genomic evaluation has caused profound changes in dairy cattle breeding. All young bulls bought by major artificial insemination organizations now are selected based on such evaluation...
  33. ncbi Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition
    Bernard Grisart
    Department of Genetics, Faculty of Veterinary Medicine, University of Liège B43, 4000 Liege, Belgium
    Genome Res 12:222-31. 2002
    ....
  34. ncbi Evidence for pleiotropism and recent selection in the PLAG1 region in Australian Beef cattle
    M R S Fortes
    Cooperative Research Centre for Beef Genetic Technologies Armidale, Armidale, NSW, 2351, Australia Queensland Alliance for Agriculture and Food Innovation, Centre for Animal Science, The University of Queensland, Gatton, QLD, 4343, Australia CSIRO Animal, Food and Health Sciences, Queensland Bioscience Precinct, Brisbane, QLD, 4067, Australia
    Anim Genet 44:636-47. 2013
    A putative functional mutation (rs109231213) near PLAG1 (BTA14) associated with stature was studied in beef cattle. Data from 8199 Bos taurus, Bos indicus and Tropical Composite cattle were used to test the associations between ..
  35. pmc Solexa sequencing of novel and differentially expressed microRNAs in testicular and ovarian tissues in Holstein cattle
    Jinming Huang
    Laboratory of Molecular Breeding, Center of Dairy Cattle Research, Shandong Academy of Agricultural Sciences, China
    Int J Biol Sci 7:1016-26. 2011
    ..role in the development and function of male and female reproductive organs and germ cells in mammals, including cattle. In the present study, we identified novel and differentially expressed miRNAs in the testis and ovary in Holstein ..
  36. ncbi Crystal structure of rhodopsin: A G protein-coupled receptor
    K Palczewski
    Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA
    Science 289:739-45. 2000
    ..Identification of a set of residues that mediate interactions between the transmembrane helices and the cytoplasmic surface, where G-protein activation occurs, also suggests a possible structural change upon photoactivation...
  37. ncbi Molecular epidemiology of cryptosporidiosis: an update
    Lihua Xiao
    Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Bldg 22, Rm 14, 4770 Burford Highway, Atlanta, GA 30341, USA
    Exp Parasitol 124:80-9. 2010
    ..The wide use of a new generation of genotyping and subtyping tools in well designed epidemiologic studies should lead to a more in-depth understanding of the epidemiology of cryptosporidiosis in humans and animals...
  38. pmc Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus
    Anna C Shore
    Microbiology Research Unit, Dublin Dental University Hospital, University of Dublin, Trinity College Dublin, Dublin, Ireland
    Antimicrob Agents Chemother 55:3765-73. 2011
    ..aureus strains were predominantly from bovine sources. The highly divergent nature of SCCmec XI relative to other SCCmec elements indicates that it may have originated in another taxon...
  39. pmc Beyond the consensus: dissecting within-host viral population diversity of foot-and-mouth disease virus by using next-generation genome sequencing
    Caroline F Wright
    University of Glasgow Centre for Virus Research, Glasgow G12 8QQ, UK
    J Virol 85:2266-75. 2011
    ..8 × 10(-4) per nucleotide. The greater depth of detection achieved by NGS demonstrates that this method is a powerful and valuable tool for the dissection of FMDV populations within hosts...
  40. pmc Imputation of missing genotypes from sparse to high density using long-range phasing
    Hans D Daetwyler
    Biosciences Research Division, Department of Primary Industries, Bundoora 3083, Australia
    Genetics 189:317-27. 2011
    ..We also tested the algorithm in a real Holstein cattle data set to impute 50K genotypes in animals with a sparse 3K genotype...
  41. ncbi Effect of imputing markers from a low-density chip on the reliability of genomic breeding values in Holstein populations
    R Dassonneville
    INRA, UMR1313 Génétique Animale et Biologie Intégrative GABI, 78350 Jouy en Josas, France
    J Dairy Sci 94:3679-86. 2011
    ..48 based on EuroGenomics reference data in the Nordic validation, and the reliability of GEBV using the imputed SNP data was 0.41 based on national reference data, and 0.44 based on EuroGenomics reference data in the French validation...
  42. pmc Polymorphic regions affecting human height also control stature in cattle
    Jennie E Pryce
    Biosciences Research Division, Department of Primary Industries, Bundoora, Victoria 3083, Australia
    Genetics 187:981-4. 2011
    ..Single nucleotide polymorphisms close to eight of these genes were significantly associated with stature in cattle (Bos taurus and Bos indicus)...
  43. ncbi Pigment epithelium-derived factor: a potent inhibitor of angiogenesis
    D W Dawson
    Department of Microbiology Immunology, Department of Pathology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Science 285:245-8. 1999
    ..These results suggest that PEDF may be of therapeutic use, especially in retinopathies where pathological neovascularization compromises vision and leads to blindness...
  44. ncbi Ante mortem diagnosis of tuberculosis in cattle: a review of the tuberculin tests, gamma-interferon assay and other ancillary diagnostic techniques
    R de la Rua-Domenech
    Department for Environment, Food and Rural Affairs, Tuberculosis Division, 1A Page Street, London SW1P 4PQ, United Kingdom
    Res Vet Sci 81:190-210. 2006
    ..Tests of humoral (antibody) immunity, Mycobacterium bovis PCR probes on early tissue cultures or live cattle specimens, and tests based on "electronic nose" technology have been developed more recently...
  45. ncbi Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
    Tony Yeung
    Institute for Medicine and Engineering, University of Pennsylvania, PA 19104, USA
    Cell Motil Cytoskeleton 60:24-34. 2005
    ..These results support the hypothesis that mechanical factors impact different cell types in fundamentally different ways, and can trigger specific changes similar to those stimulated by soluble ligands...
  46. pmc Linkage disequilibrium and persistence of phase in Holstein-Friesian, Jersey and Angus cattle
    A P W de Roos
    CRV, 6800 AL Arnhem, The Netherlands
    Genetics 179:1503-12. 2008
    ..The objectives of this study were to compare the extent of LD and the persistence of LD phase across multiple cattle populations...
  47. ncbi Imputation of genotypes with low-density chips and its effect on reliability of direct genomic values in Dutch Holstein cattle
    H A Mulder
    Animal Breeding and Genomics Centre, Wageningen UR Livestock Research, PO Box 65, 8200 AB Lelystad, The Netherlands
    J Dairy Sci 95:876-89. 2012
    Genomic selection using 50,000 single nucleotide polymorphism (50k SNP) chips has been implemented in many dairy cattle breeding programs. Cheap, low-density chips make genotyping of a larger number of animals cost effective...
  48. ncbi Footprints of selection in the ancestral admixture of a New World Creole cattle breed
    Mathieu Gautier
    INRA, UMR CBGP INRA CIRAD IRD Supagro, Montferrier sur Lez, France
    Mol Ecol 20:3128-43. 2011
    ..Originating from several waves of recent introduction from European (EUT), African (AFT) and zebus (ZEB) cattle, New World Creole cattle allow investigating the response to tropical environmental challenges of these three ..
  49. pmc The genome response to artificial selection: a case study in dairy cattle
    Laurence Flori
    INRA, UMR de Génétique Animale et Biologie Intégrative, Jouy en Josas, France
    PLoS ONE 4:e6595. 2009
    Dairy cattle breeds have been subjected over the last fifty years to intense artificial selection towards improvement of milk production traits...
  50. pmc Application of site and haplotype-frequency based approaches for detecting selection signatures in cattle
    Saber Qanbari
    Animal Breeding and Genetics Group, Department of Animal Sciences, Georg August University, 37075 Gottingen, Germany
    BMC Genomics 12:318. 2011
    ..methods--integrated Haplotype Homozygosity Score (|iHS|) and population differentiation index (FST)--were applied to identify traces of decades of intensive artificial selection for traits of economic importance in modern cattle.
  51. pmc Epidemiology of Escherichia coli O157:H7 outbreaks, United States, 1982-2002
    Josefa M Rangel
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 11:603-9. 2005
    ..3%) laboratory-related. The food vehicle for 75 (41%) foodborne outbreaks was ground beef, and for 38 (21%) outbreaks, produce...
  52. ncbi A genome-wide scan for signatures of recent selection in Holstein cattle
    S Qanbari
    Animal Breeding and Genetics Group, Department of Animal Sciences, Georg August University, 37075 Gottingen, Germany
    Anim Genet 41:377-89. 2010
    ..available 50 K SNP chip was used for tagging the genome-wide footprints of positive selection in Holstein-Friesian cattle. For this purpose, we employed the recently described Extended Haplotype Homozygosity test, which detects ..
  53. ncbi A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
    Eleni Tzima
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 437:426-31. 2005
    ..Therefore, this mechanosensing pathway is required for the earliest-known events in atherogenesis...
  54. ncbi A genome scan for quantitative trait loci influencing carcass, post-natal growth and reproductive traits in commercial Angus cattle
    M C McClure
    Division of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
    Anim Genet 41:597-607. 2010
    To gain insight into the number of loci of large effect that underlie variation in cattle, a quantitative trait locus (QTL) scan for 14 economically important traits was performed in two commercial Angus populations using 390 ..
  55. ncbi Conceptus-induced changes in the endometrial transcriptome: how soon does the cow know she is pregnant?
    N Forde
    School of Agriculture, Food Science and Veterinary Medicine, Conway Institute, University College Dublin, Belfield, Dublin, Ireland
    Biol Reprod 85:144-56. 2011
    ..The identified genes represent known and novel early markers of conceptus development and/or return to cyclicity and may be useful to identify the earliest stage at which the endometrial response to the conceptus is detectable...
  56. pmc Genome wide association studies for milk production traits in Chinese Holstein population
    Li Jiang
    Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, People s Republic of China
    PLoS ONE 5:e13661. 2010
    ..genotyping technologies open a broad avenue for exploring genes associated with milk production traits in dairy cattle. Motivated by pinpointing novel quantitative trait nucleotide (QTN) across Bos Taurus genome, the present study is ..
  57. pmc Design of a bovine low-density SNP array optimized for imputation
    Didier Boichard
    UMR1313 Animal Genetics and Integrative Biology, National Institute for Agricultural Research INRA, Jouy en Josas, France
    PLoS ONE 7:e34130. 2012
    ..The minor allele frequencies were similar across taurine beef and dairy breeds as was the proportion of SNPs that were polymorphic. The new BovineLD chip should facilitate low-cost genomic selection in taurine beef and dairy cattle.
  58. ncbi Crystal structure of the ligand-free G-protein-coupled receptor opsin
    Jung Hee Park
    Institut für Medizinische Physik und Biophysik CC2, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Nature 454:183-7. 2008
    ..The opsin structure sheds new light on ligand binding to GPCRs and on GPCR activation...
  59. pmc Brucellosis: an overview
    M J Corbel
    National Institute of Biological Standards and Control, South Mimmas, Potters Bar, Hertfordshire, United Kingdom
    Emerg Infect Dis 3:213-21. 1997
    Brucellosis remains a major zoonosis worldwide. Although many countries have eradicated Brucella abortus from cattle, in some areas Brucella melitensis has emerged as a cause of infection in this species as well as in sheep and goats...
  60. pmc SNP discovery in the bovine milk transcriptome using RNA-Seq technology
    Angela Cánovas
    IRTA, Genetica i Millora Animal, 191 Alcalde Rovira Roure Av, 25198, Lleida, Spain
    Mamm Genome 21:592-8. 2010
    ..SNP detection, and provides more than 33,000 SNPs located in coding regions of genes expressed during lactation that can be used to develop genotyping platforms to perform marker-trait association studies in Holstein cattle.
  61. pmc Evolutionary genomics of Staphylococcus aureus reveals insights into the origin and molecular basis of ruminant host adaptation
    Caitriona M Guinane
    The Roslin Institute and Centre for Infectious Diseases, Royal Dick School of Veterinary Studies, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Genome Biol Evol 2:454-66. 2010
    ..aureus biotyping scheme. Taken together, these data provide broad new insights into the origin and molecular basis of S. aureus ruminant host specificity...
  62. ncbi Shiga toxin-producing Escherichia coli: an overview
    C L Gyles
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    J Anim Sci 85:E45-62. 2007
    The objective of this review is to highlight the importance of cattle in human disease due to Shiga toxin-producing Escherichia coli (STEC) and to discuss features of STEC that are important in human disease...
  63. pmc Methicillin resistant Staphylococcus aureus ST398 in veal calf farming: human MRSA carriage related with animal antimicrobial usage and farm hygiene
    Haitske Graveland
    Division of Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    PLoS ONE 5:e10990. 2010
    ..In this cross-sectional study, we investigated factors associated with MRSA colonization in veal calves and humans working and living on these farms...
  64. pmc Copy number variation in the bovine genome
    João Fadista
    Group of Molecular Genetics and Systems Biology, Department of Genetics and Biotechnology, Faculty of Agricultural Sciences, Aarhus University, Blichers alle 20, DK 8830 Tjele, Denmark
    BMC Genomics 11:284. 2010
    ..Notwithstanding, little is known about the extent to which CNV contributes to genetic variation in cattle.
  65. pmc Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows
    John B Cole
    Animal Improvement Programs Laboratory, Agricultural Research Service, USDA, Beltsville, Maryland, USA
    BMC Genomics 12:408. 2011
    ..Here, we report results of a genome-wide analysis of predicted transmitting ability (PTA) of 31 production, health, reproduction and body conformation traits in contemporary Holstein cows...
  66. pmc Imputation of high-density genotypes in the Fleckvieh cattle population
    Hubert Pausch
    Lehrstuhl fuer Tierzucht, Technische Universitaet Muenchen, 85354, Freising, Germany
    Genet Sel Evol 45:3. 2013
    Currently, genome-wide evaluation of cattle populations is based on SNP-genotyping using ~ 54,000 SNP. Increasing the number of markers might improve genomic predictions and power of genome-wide association studies...
  67. ncbi Comparison of genomic predictions using medium-density (∼54,000) and high-density (∼777,000) single nucleotide polymorphism marker panels in Nordic Holstein and Red Dairy Cattle populations
    G Su
    Department of Molecular Biology and Genetics, Aarhus University, DK 8830 Tjele, Denmark
    J Dairy Sci 95:4657-65. 2012
    ..54K) and high-density marker panels (∼777,000; 777K), based on data from Nordic Holstein and Red Dairy Cattle (RDC). The Holstein data comprised 4,539 progeny-tested bulls, and the RDC data 4,403 progeny-tested bulls...
  68. pmc Composition and similarity of bovine rumen microbiota across individual animals
    Elie Jami
    Department of Ruminant Science, Institute of Animal Sciences, Agricultural Research Organization, Bet Dagan, Israel
    PLoS ONE 7:e33306. 2012
    The bovine rumen houses a complex microbiota which is responsible for cattle's remarkable ability to convert indigestible plant mass into food products...
  69. pmc Association, effects and validation of polymorphisms within the NCAPG - LCORL locus located on BTA6 with feed intake, gain, meat and carcass traits in beef cattle
    Amanda K Lindholm-Perry
    United States Department of Agriculture, Agricultural Research Service, U S Meat Animal Research Center, Clay Center, NE 68933, USA
    BMC Genet 12:103. 2011
    ..002) with average daily feed intake (ADFI) in a population of crossbred beef cattle. The SNP were clustered in a 570 kb region around 38 Mb on the draft sequence of bovine chromosome 6 (BTA6), an ..
  70. pmc Accuracies of genomic breeding values in American Angus beef cattle using K-means clustering for cross-validation
    Mahdi Saatchi
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 43:40. 2011
    ..The objective of this study was to estimate marker effects to derive prediction equations for direct genomic values for 16 routinely recorded traits of American Angus beef cattle and quantify corresponding accuracies of prediction.
  71. ncbi Genome-wide association studies of female reproduction in tropically adapted beef cattle
    R J Hawken
    Cooperative Research Centre for Beef Genetic Technologies, University of New England, Armidale, New South Wales 2351, Australia
    J Anim Sci 90:1398-410. 2012
    ..To elucidate the genetics underlying reproduction in beef cattle, we performed a genome-wide association study using the bovine SNP50 chip in 2 tropically adapted beef cattle ..
  72. pmc Molecular epidemiology of mastitis pathogens of dairy cattle and comparative relevance to humans
    Ruth N Zadoks
    Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik EH26 0PZ, UK
    J Mammary Gland Biol Neoplasia 16:357-72. 2011
    ..In this review, we summarize knowledge gleaned from two decades of molecular epidemiological studies of mastitis pathogens in dairy cattle and discuss aspects of comparative relevance to human medicine.
  73. ncbi Accuracy of prediction of genomic breeding values for residual feed intake and carcass and meat quality traits in Bos taurus, Bos indicus, and composite beef cattle
    S Bolormaa
    Victorian Department of Primary Industries, Bundoora, VIC 3083, Australia
    J Anim Sci 91:3088-104. 2013
    ..genomic predictions for 19 traits including feed efficiency, growth, and carcass and meat quality traits in beef cattle. The 10,181 cattle in our study had real or imputed genotypes for 729,068 SNP although not all cattle were ..
  74. ncbi SNP discovery and allele frequency estimation by deep sequencing of reduced representation libraries
    Curtis P van Tassell
    Bovine Functional Genomics Laboratory, United States Department of Agriculture, Agricultural Research Service, 10300 Baltimore Avenue, Beltsville, Maryland 20705, USA
    Nat Methods 5:247-52. 2008
    ..Using nearly 50 million sequences generated on an Illumina Genome Analyzer from DNA of 66 cattle representing three populations, we identified 62,042 putative SNPs and predicted their allele frequencies...
  75. ncbi Temporal gene expression profiling of liver from periparturient dairy cows reveals complex adaptive mechanisms in hepatic function
    Juan J Loor
    Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    Physiol Genomics 23:217-26. 2005
    ..and +49 days relative to parturition for transcript profiling using a microarray consisting of 7,872 annotated cattle cDNA inserts. More than 5,000 cDNA elements represented on the microarray were expressed in liver...
  76. ncbi Spa type distribution in Staphylococcus aureus originating from pigs, cattle and poultry
    H Hasman
    Technical University of Denmark, National Food Institute, Bulowsvej 27, 1790 Copenhagen V, Denmark
    Vet Microbiol 141:326-31. 2010
    ..aureus (MRSA) of clonal complex 398 (CC398) is emerging globally among production animals such as cattle, pigs and poultry as well as among humans...
  77. pmc Comparison of transcriptomic landscapes of bovine embryos using RNA-Seq
    Wen Huang
    Department of Dairy Science, University of Wisconsin, Madison, WI 53706, USA
    BMC Genomics 11:711. 2010
    ..Although RNA-seq has been demonstrated in many organisms, no study has provided a comprehensive investigation of the bovine transcriptome using RNA-seq...
  78. ncbi Microarray based study on virulence-associated genes and resistance determinants of Staphylococcus aureus isolates from cattle
    Stefan Monecke
    Institute for Medical Microbiology and Hygiene, Faculty of Medicine, Carl Gustav Carus at the Technical University of Dresden, Fetscherstrasse 74, D 01307, Dresden, Germany
    Vet Microbiol 125:128-40. 2007
    ..Especially, infection of cattle is of high economic relevance as S. aureus is an important causal agent of bovine mastitis...
  79. pmc The accuracy of Genomic Selection in Norwegian red cattle assessed by cross-validation
    Tu Luan
    Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, Box 5003, N 1432 As, Norway
    Genetics 183:1119-26. 2009
    ..To achieve a similar accuracy for the health traits probably more records will be needed...
  80. pmc Rift Valley fever during rainy seasons, Madagascar, 2008 and 2009
    Soa Fy Andriamandimby
    Institut Pasteur, Antananarivo, Madagascar
    Emerg Infect Dis 16:963-70. 2010
    ..To better predict and respond to RVF outbreaks in Madagascar, further epidemiologic studies are needed, such as RVFV complete genome analysis, ruminant movement mapping, and surveillance implementation...
  81. ncbi Hot topic: a unified approach to utilize phenotypic, full pedigree, and genomic information for genetic evaluation of Holstein final score
    I Aguilar
    Animal and Dairy Science Department, University of Georgia, Athens 30602 Instituto Nacional de Investigación Agropecuaria, Las Brujas 90200, Uruguay
    J Dairy Sci 93:743-52. 2010
    ..Advantages of single-step evaluations should increase in the future when animals are pre-selected on genotypes...
  82. ncbi Prediction of unobserved single nucleotide polymorphism genotypes of Jersey cattle using reference panels and population-based imputation algorithms
    K A Weigel
    Department of Dairy Science, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Dairy Sci 93:2229-38. 2010
    The availability of dense single nucleotide polymorphism (SNP) genotypes for dairy cattle has created exciting research opportunities and revolutionized practical breeding programs...
  83. pmc Whole genome resequencing of black Angus and Holstein cattle for SNP and CNV discovery
    Paul Stothard
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada
    BMC Genomics 12:559. 2011
    ..advances in DNA sequencing technology allow for in-depth characterization of the genetic variations present in cattle. Here we describe the whole-genome resequencing of two Bos taurus bulls from distinct breeds for the purpose of ..
  84. pmc Novel multilocus measure of linkage disequilibrium to estimate past effective population size
    Ben J Hayes
    Victorian Institute of Animal Science, Department of Natural Resources and Environment, Attwood, Victoria, 3049, Australia
    Genome Res 13:635-43. 2003
    ..We illustrate the utility of CSH by calculating CSH from human and dairy cattle SNP and microsatellite marker data, and predicting N at various times in the past for each species...
  85. pmc Characterization of microRNA expression in bovine adipose tissues: a potential regulatory mechanism of subcutaneous adipose tissue development
    Weiwu Jin
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G2P5, Canada
    BMC Mol Biol 11:29. 2010
    ..e. adipogenesis). However, no miRNA to date has been reported to modulate adipogenesis and lipid deposition in beef cattle.
  86. pmc A common reference population from four European Holstein populations increases reliability of genomic predictions
    Mogens S Lund
    Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University, AU Foulum, PO Box 50, DK 8830 Tjele, Denmark
    Genet Sel Evol 43:43. 2011
    ..Increased accuracies of genomic predictions depend on the number of individuals added to the reference population, the reliability of their phenotypes, and the relatedness of the populations that are combined...
  87. ncbi Progress in the control of bovine tuberculosis in Spanish wildlife
    Christian Gortazar
    IREC CSIC UCLM JCCM, Ronda de Toledo s n, Ciudad Real 13071, Spain
    Vet Microbiol 151:170-8. 2011
    Despite the compulsory test and slaughter campaigns in cattle, bovine tuberculosis (bTB) is still present in Spain, and the role of wildlife reservoirs is increasingly recognized...
  88. pmc The impact of genetic relationship information on genomic breeding values in German Holstein cattle
    David Habier
    Institute of Animal Breeding and Husbandry, Christian Albrechts University of Kiel, Olshausenstrasse 40, 24098 Kiel, Germany
    Genet Sel Evol 42:5. 2010
    ..However, this impact and the accuracy of GEBVs due to linkage disequilibrium (LD), which is fairly persistent over generations, must be known to implement future breeding programs...
  89. pmc Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans
    P Boerlin
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Clin Microbiol 37:497-503. 1999
    ....
  90. ncbi A relationship matrix including full pedigree and genomic information
    A Legarra
    INRA, UR631 SAGA, BP 52627, 32326 Castanet Tolosan, France
    J Dairy Sci 92:4656-63. 2009
    ..Numerical examples and alternative expressions are discussed. Matrix H is suitable for iteration on data algorithms that multiply a vector times a matrix, such as preconditioned conjugated gradients...
  91. pmc Molecular correlates of host specialization in Staphylococcus aureus
    Lisa Herron-Olson
    Department of Microbiology, Veterinary Pathobiology and Biomedical Genomics Center, University of Minnesota, Saint Paul, Minnesota, United States of America
    PLoS ONE 2:e1120. 2007
    ..of Staphylococcus aureus isolates that are recovered from either serious infections in humans or from mastitis in cattle represent genetically distinct sets of clonal groups...
  92. ncbi Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics
    Juri Rappsilber
    Center of Experimental BioInformatics, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK 5230 Odense M, Denmark
    Anal Chem 75:663-70. 2003
    ..Five femtomole of tryptic BSA digest could be recovered quantitatively. We have found that the Stage system is well-suited as a universal sample preparation system for proteomics...
  93. pmc Escherichia coli infection induces distinct local and systemic transcriptome responses in the mammary gland
    Simone Mitterhuemer
    Laboratory for Functional Genome Analysis LAFUGA, Gene Center, LMU Munich, Feodor Lynen Str 25, 81377 Munich, Germany
    BMC Genomics 11:138. 2010
    ..coli (6 h and 24 h post infection), from neighboring quarters of the same animals, and from untreated control animals...
  94. pmc Bos taurus genome assembly
    Yue Liu
    Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    BMC Genomics 10:180. 2009
    ..The assembly method combines the BAC plus WGS local assembly used for the rat and sea urchin with the whole genome shotgun (WGS) only assembly used for many other animal genomes including the rhesus macaque...
  95. ncbi Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper--Excel-based tool using pair-wise correlations
    Michael W Pfaffl
    Physiology, FML Weihenstephan, Centre of Life and Food Science, Technical University of Munich, Germany
    Biotechnol Lett 26:509-15. 2004
    ..The BestKeeper application and necessary information about data processing and handling can be downloaded on http://www.wzw.tum.de/gene-quantification/bestkeeper.html...
  96. pmc Viral booster vaccines improve Mycobacterium bovis BCG-induced protection against bovine tuberculosis
    H Martin Vordermeier
    TB Research Group, VLA Weybridge, New Haw, Addlestone, Surrey, United Kingdom
    Infect Immun 77:3364-73. 2009
    ..Here we report the first efficacy data on using these vaccines in cattle, a natural target species of tuberculous infection...
  97. ncbi The role of wild animal populations in the epidemiology of tuberculosis in domestic animals: how to assess the risk
    L A L Corner
    Department of Large Animal Clinical Studies, University College Dublin, Dublin, Ireland
    Vet Microbiol 112:303-12. 2006
    ..A detailed analysis of Mycobacterium bovis infection in the Eurasian badger (Meles meles) in Ireland and their role as a reservoir of infection for cattle is also presented.
  98. ncbi Abundance of six tetracycline resistance genes in wastewater lagoons at cattle feedlots with different antibiotic use strategies
    Nicholas Peak
    Department of Civil, Environmental, and Architectural Engineering, University of Kansas, Lawrence, KS 66045, USA
    Environ Microbiol 9:143-51. 2007
    ..Eight lagoons at five cattle feedlots in the Midwestern United States were monitored for 6 months...
  99. pmc International genomic evaluation methods for dairy cattle
    Paul M Vanraden
    Animal Improvement Programs Laboratory, USDA, Building 5 BARC West, Beltsville, MD 20705 2350, USA
    Genet Sel Evol 42:7. 2010
    Genomic evaluations are rapidly replacing traditional evaluation systems used for dairy cattle selection. Higher reliabilities from larger genotype files promote cooperation across country borders...
  100. ncbi A bovine homologue of the human TSPY gene
    S Jakubiczka
    Institut fur Humangenetik, Medizinische Hochschule Hannover, Germany
    Genomics 17:732-5. 1993
    ..The clone isolated from the bovine genome has two regions that are highly conserved between homo and bos. One stretch of DNA is homologous in 45 of 51 bp (88%), and the other stretch shares 71 of 100 bp (71%)...
  101. ncbi Consensus recommendations on diagnostic testing for the detection of paratuberculosis in cattle in the United States
    Michael T Collins
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706 1102, USA
    J Am Vet Med Assoc 229:1912-9. 2006
    ..The report is intended to provide simple, practical, cost-effective consensus testing recommendations for cattle herds that are not enrolled in the US Test-Negative Program...

Research Grants75

  1. A Sindbis virus-based Vaccine Against RVFV Infection
    Ilya Frolov; Fiscal Year: 2006
    ..and spread across the Red Sea to Saudi Arabia and Yemen, causing devastating disease outbreaks in sheep and cattle. The RVFV has potential for use in bioterrorism, and its projected effect on U.S...
  2. Mycobacterium avium subspecies in Crohn's Disease
    Saleh Naser; Fiscal Year: 2005
    ..mycobacterial theory is based on the significant similarity between CD and Johne's disease, a chronic enteritis in cattle that is caused by MAP...
  3. Investigation of Occupational Exposure to and Infection by MRSA in Rural Iowa
    Tara Smith; Fiscal Year: 2012
    ..We will examine 30 farms during this research, including farms with live swine, cattle, and poultry. In the second part of our research plan, we will examine transmission of S...
  4. ANALYSIS OF TRYPANOSOME MRNA SYNTHESIS BY GENE TRANSFER
    Vivian Bellofatto; Fiscal Year: 2010
    ..In Africa, Trypanosoma brucei ssp. infect humans and domestic cattle, causing African sleeping sickness and Nagana, respectively. Human infection by the subspecies T. b...
  5. Characterize functions of T. brucei RAP1 and TRF in antigenic variation and telom
    Bibo Li; Fiscal Year: 2013
    ..applicant): Trypanosoma brucei is a protozoan parasite that causes African trypanosomiasis in humans and nagana in cattle. In mammalian hosts, bloodstream form (BF) T...
  6. Trophoblast MHC-I: Trigger for Immune-Mediated Rejection of Cloned Bovine Fetuses
    Kenneth L White; Fiscal Year: 2011
    ..The incidence of immune-mediated abortion and placental insufficiency in both humans and cattle are greatly increased with the use of assisted reproductive technologies such as in vitro fertilization...
  7. Novel High Affinity and Long-Acting Bovine FSH Analogs for Veterinary Superovulat
    BRUCE DALE WEINTRAUB; Fiscal Year: 2012
    ..in CHO-DG44 cells in preparation for Phase 2 large-scale production, purification and superovulation studies in cattle. This completely novel recombinant bFSH analog protected by international patents until 2032 &without a known ..
  8. Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigen
    Ana M Espino; Fiscal Year: 2013
    ..hepatica causes liver fluke disease or fascioliasis, thereby affecting the health of humans, as well as sheep, cattle and goats, among others mammalians. Fascioliasis causes losses in agriculture estimated at >US3...
  9. The development of a recombinant vaccine against human onchocerciasis
    Sara Lustigman; Fiscal Year: 2013
    ..Importantly, protective immunity against Ov larvae has now been definitively demonstrated in humans, cattle and mice, thereby proving the conceptual underpinnings that a vaccine can be produced against this infection...
  10. Research and Development of a Novel System to Produce Polysaccharide Conjugate Va
    Peng George Wang; Fiscal Year: 2013
    ..coli fermentation. Such a bioconjugate already offers good possibility to be used to induce antibodies in cows or cattle to kill an inoculum of E. coli O157, since the vaccines can be produced in large scale economically...
  11. Role of Fetal Steroids in Formation and Activation of Bovine Ovarian Follicles
    Joanne E Fortune; Fiscal Year: 2010
    ..In cattle, sheep, and other large mammals, including humans, primordial follicles form over a number of weeks during fetal ..
  12. Heterologous abs from llama and chicken egg yolk to prevent rotavirus diarrhea
    Linda J Saif; Fiscal Year: 2010
    ..of state-of-the-art technology for diagnosis (assays, reagents) and treatments (vaccines) for RV infections of cattle, the major agricultural commodity in Argentina...
  13. SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTING
    Shinichiro Kurosawa; Fiscal Year: 2011
    ..There are certain strains of dangerous E. coli bacteria that can infect crops or cattle, and can be transmitted through our food distribution system to thousands of households...
  14. Mechanisms of Resistance and Susceptibility to African Trypanosome Infection
    Stephen L Hajduk; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Trypanosoma brucei brucei causes Nagana in cattle but is non-infectious to humans because of its susceptibility to the cytotoxic activity of normal human serum...
  15. Immunogenicity of the Type IV Secretin System
    WENDY CATHERINE BROWN; Fiscal Year: 2012
    ..By testing cattle that express a diverse repertoire of class II haplotypes, representative of the diversity of MHC class II ..
  16. A Phase I Study to Evaluate the Safety and Immunogenicity of HPV 16 L2 11-200
    WARNER KING HUH; Fiscal Year: 2012
    ..Vaccination of cattle with bovine papillomavirus type 4 (BPV4) L2 11-200 protects against BPV4 challenge on the soft palate...
  17. Preventing Human Prion Diseases - Inactivation of Prions
    Stanley B Prusiner; Fiscal Year: 2010
    ..plan to study three strains of prions passaged in mice: RML and 301V, which originated from sheep with scrapie and cattle with BSE, respectively, plus a novel synthetic strain MoSP1, which is the most stable strain reported to date...
  18. Impact of Microparticles on Oral TSE Infections
    Joel A Pedersen; Fiscal Year: 2012
    ..Microparticles are found in many other substances than soil. Meat and bone meal (MBM), a commonly used cattle food supplement thought responsible for BSE in Europe...
  19. Development of a Novel Rift Valley Fever Virus Vaccine
    Shinji Makino; Fiscal Year: 2013
    ..disease of sub-Saharan Africa that can emerge in explosive mosquito-borne epidemics, decimating herds of sheep and cattle and resulting in enormous economic losses;humans are infected concurrently, and their infection results in ..
  20. Point-of-Care Diagnostic Assay for Direct Detection of Pathogenic Leptospira
    Jeffrey Smith; Fiscal Year: 2010
    ..The World Health Organization lists the groups of people at risk of the infection ranging from cattle and pig farmers to veterinarians, butchers and slaughterhouse workers to children playing in rain puddles or mud, ..
  21. Structure and assembly of the fungal prion HET-s
    William N Wan; Fiscal Year: 2013
    ..TSEs include scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle, chronic wasting disease (CWD) in deer and elk, and several forms of Creutzfeldt-Jakob disease (CJD) in humans...
  22. REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEI
    CHING CHUNG WANG; Fiscal Year: 2012
    ..are the causative pathogens of African sleeping sickness in humans and nagana in cattle. They are a family of deeply branched eukaryotes that exhibit many unique features during their cell cycle ..
  23. Liposome-siRNA-Peptide Complexes as Therapy to Cure Prion Diseases in Mouse Model
    Mark D Zabel; Fiscal Year: 2013
    ..spongiform encephalopathies (TSEs) include scrapie in sheep;bovine spongiform encephalopathy (BSE) in cattle;chronic wasting disease (CWD) in deer and elk;and Kuru and Creutzfeldt-Jakob disease in humans...
  24. 2009 Spirochetes, Biology of
    David A Haake; Fiscal Year: 2010
    ..including syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been very difficult to study...
  25. Lysosomal biogenesis and function in African trypanosomes
    James D Bangs; Fiscal Year: 2013
    ..are parasitic protozoa that cause human African trypanosomiasis (HAT, sleeping sickness), as well as nagana in cattle and other livestock...
  26. Epigenetic Modulation of PTPG by Zeranol in Beef Increases Breast Cancer Risk
    Young C Lin; Fiscal Year: 2010
    ..The overall HYPOTHESIS to be evaluated is that the consumption of beef products, derived from Z-implanted beef cattle may possess a potential health impact on human consumers, particularly with respect to reproductive endocrinology ..
  27. The role of Variable Erythrocyte Surface Antigen (VESA1) proteins in Babesia bovi
    KERRY SUE SONDGEROTH; Fiscal Year: 2011
    ..This project will use Babesia bovis infection of cattle as a natural animal model of cytoadherence and virulence, and will address a significant knowledge gap to ..
  28. Regulation of osteoclast biology by anion exchanger SLC4A2 in mouse and human sys
    Antonios O Aliprantis; Fiscal Year: 2013
    ..A recent publication has identified a nearly identical phenotype in cattle that lack SLC4A2...
  29. EVC2: A novel modulator in tooth development
    Yoshiyuki Mochida; Fiscal Year: 2013
    ..A causative gene, LIMBIN for bovine chondrodysplastic dwarfism (bcd) found in Japanese brown cattle was later identified as the bovine ortholog of EVC2, indicating the significance of EVC2 protein function...
  30. One Health Innovation Fellowships for Zoonotic Disease Research In Mongolia
    GREGORY CHARLES GRAY; Fiscal Year: 2013
    ..Mongolia has undergone rapid change with increases in mining operations and animal production of sheep, goats, and cattle. Large segments of the normally nomadic pastoral populations have begun migrating to urban areas and introducing ..
  31. Parameters that govern initiation of VSG switching in T.brucei
    F Nina Papavasiliou; Fiscal Year: 2013
    ..The parasite Trypanosoma brucei is the causative agent of African sleeping sickness in humans and of Nagana in cattle, and one of the leading impediments to development in much of sub-Saharan Africa. T...
  32. Pathogenesis, Transmission and Detection of Zoonotic Prion Diseases (P01)
    Claudio Soto; Fiscal Year: 2012
    ..Although rare, the recent outbreak of Bovine Spongiform Encephalopathy(BSE) in cattle and Chronic Wasting disease (CWD) in cervids and the transmission of the disease from cattle to humans have caused ..
  33. REGULATION OF THE DEVELOPMENT OF TRYPANOSOMA BRUCEI
    Ching Wang; Fiscal Year: 2009
    ..are the causative pathogens of spp., African sleeping sickness in humans and nagana in cattle. They are a family of sickness in humans and nagana in cattle...
  34. Environmental Health Specialist Network
    RICHARD NORMAN DANILA; Fiscal Year: 2013
    ..specific questions about well water and other exposures), and application of GIS using data sources such as cattle density, geologic sensitivity to groundwater contamination, and climate variables (e.g., flooding)...
  35. Development of a Biochemical Diagnosis for Creutzfeldt-Jakob disease
    Claudio Soto; Fiscal Year: 2013
    ..disease (sCJD), the most common form, and variant CJD (vCJD) which is associated to consumption of cattle meat infected by bovine spongiform encephalopathy...
  36. Epigenetic control of preimplantation embryo development
    Pablo Juan Ross; Fiscal Year: 2013
    ..Early embryonic mortality is a major cause of infertility in dairy cattle and humans...
  37. RNA CAPPING IN TRYPANOSOMES
    Christian Tschudi; Fiscal Year: 2012
    ..agents of African trypanosomiasis or sleeping sickness in humans and a wasting and fatal disease (Nagana) in cattle, domestic pigs and other farm animals causing a profound effect on the economy of much of the continent...
  38. Molecular Mechanisms of Prion and Amyloid Propagation
    Christopher P Jaroniec; Fiscal Year: 2013
    ..disorders that include Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy in cattle. Mammalian prions propagate by a mechanism involving the conformational conversion of a largely a-helical cellular ..
  39. Identifying components of Toxoplasma oocysts that confer environmental resistance
    HEATHER MICHELLE FRITZ; Fiscal Year: 2013
    ..g. swine, cattle, sheep) containing bradyzoite tissue cysts, or through congenital transmission...
  40. Feed Safety and BSE/Ruminant Feed Ban Support Project (U18)
    CLAUDIA G COLES; Fiscal Year: 2013
    ..WSDA describes Washington State's vulnerability to BSE agent release from imported Canadian cattle in age cohorts shared by the ongoing BSE positives identified by Canadian BSE surveillance...
  41. "Physical and Chemical Cues that Guide Sperm Migration"
    Mingming Wu; Fiscal Year: 2013
    ..Infertility affects about 7% of married couples in the US and the success rate of artificial insemination in the cattle industry has been dropping over the past several years...
  42. Structural basis of species-specific infectivities of two prion strains
    Peter M Tessier; Fiscal Year: 2010
    ..infectious proteins that cause devastating neurodegenerative diseases (transmissible encephalopathies) in humans, cattle and other mammals...
  43. Tuberculosis epidemiology and novel transmission routes in rural Tanzania
    Philip C Hopewell; Fiscal Year: 2013
    ..livestock keepers (pastoralists) combined with poor public health infrastructure, limited TB control measures for cattle and animal products, and a large immunocompromised human population due to HIV/AIDS, make Africa particularly ..
  44. High Throughput Screening for Foot and Mouth Disease Virus Antivirals
    John F Atkins; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The infection of cattle with Foot and Mouth Disease Virus (FMDV) causes not only great economic damage but great popular panic, e.g...
  45. Mechanisms underlying myostatin regulation and activity
    Se Jin Lee; Fiscal Year: 2013
    ..Subsequent genetic studies in cattle, sheep, dogs, and humans have all shown that the function of myostatin as a negative regulator of muscle mass has ..
  46. Key molecular mechanisms of extraneural pathogenesis and transmission of TSEs
    Mark D Zabel; Fiscal Year: 2012
    ..include chronic wating disease (CWD) of deer and elk, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jacob disease and kuru in humans...
  47. Characterization of prion protein conformational changes
    VALERIE D DAGGETT; Fiscal Year: 2010
    ..disease, fatal familial insomnia and Kuru in humans, scrapie in sheep, bovine spongiform encephalopathy in cattle, and chronic wasting disease in deer and elk. While rare, these diseases are always fatal...
  48. Evidence based control strategies of Sleeping Sickness vectors
    Serap Aksoy; Fiscal Year: 2012
    ..is at risk of HAT outbreaks due to ongoing epidemics in neighboring Uganda and increased movement of people and cattle (known reservoirs for Trypanosoma brucei rhodesiense)...
  49. LYMPHOCYTE-MEDIATED IMMUNITY TO ANAPLASMA MARGINALE
    Reginald Valdez; Fiscal Year: 1999
    ..There was some uncertainty as to the extent of the problem of acute anaplasmosis infection in cattle and how the research findings might impact the field. Since Dr...
  50. SdiA regulation of EHEC virulence
    Vanessa Sperandio; Fiscal Year: 2013
    ..The main reservoir for EHEC is cattle herds...
  51. Assembly of a Dodecahedral Virus
    Adam Zlotnick; Fiscal Year: 2013
    ..BEV is non-pathogenic even in cattle, where it is endemic...
  52. Mechanisms of prion aggregation and species barriers
    Christina Sigurdson; Fiscal Year: 2013
    ..Here we propose that the [unreadable]2-a2 loop also plays an important role for prion transmission to humans and cattle. In this proposal, we will evaluate the impact of the [unreadable]2-a2 loop residues on prion aggregation, species ..
  53. System biology approach to understand endometrial receptivity &pregnancy loss
    Thomas E Spencer; Fiscal Year: 2013
    ..endometrial receptivity an pregnancy success, which will increase production efficiency and profitability of cattle enterprises...
  54. Phosphoinositides in the T. brucei Endomembrane System
    Julia K Gilden; Fiscal Year: 2013
    ..protozoa responsible for causing human African trypanosomiasis (HAT, sleeping sickness) in humans and nagana in cattle and other livestock...
  55. Method validation and comparison for the detection of mycotoxins in novel animal
    Lisa Murphy; Fiscal Year: 2013
    ..If the Charm ROSA-M readers can be validated for the analysis of dog food, cattle feed, and swine feed, they will provide an easy method for minimally-trained personnel at multiple laboratories to ..
  56. Artiodactyl Gene Modification with Tal Effector Nucleases
    SCOTT CHRISTOPHER FAHRENKRUG; Fiscal Year: 2012
    ..studies proposed here will establish a new paradigm for the genetic modification of artiodactyls (pigs, sheep, and cattle) for use as large animal models of human disease and the production of biomedical materials...
  57. Assessing the Transmissibility of CWD to Humans
    Qingzhong Kong; Fiscal Year: 2010
    ..be transmitted to humans directly (Aim 1)? Can CWD be transmitted to humans after passage through secondary hosts (cattle or sheep) (Aim 2)? Has CWD transmission to humans already occurred (Aim 3)? The ultimate goals are to define the ..
  58. Cyclic Amplification of Prion Protein Misfolding
    Claudio Soto; Fiscal Year: 2013
    ..outbreak of Bovine Spongiform Encephalopathy and Chronic Wasting disease and the transmission of the disease from cattle to humans have risen a great public health concern...
  59. Mechanism of membrane permeabilization by a cytolytic high density lipoprotein
    JOHN MATTHEW HARRINGTON; Fiscal Year: 2010
    ..innate immunity against the mammalian parasite Trypanosoma brucei brucei, the causative agent of Nagana in African cattle. The morphologically indistinct T. brucei subspecies T. b. rhodesiense and T. b...
  60. Structural Characterization of Prion Isoforms in Multiple TSE Diseases
    MICHELE ANN MCGUIRL; Fiscal Year: 2012
    ..Familial Insomnia, and kuru (humans), scrapie (sheep), chronic wasting disease (elk, deer), and mad cow disease (cattle)...
  61. Mathematical and Statistical Modeling of Mycobacterial Disease Control
    REBECCA LEE SMITH; Fiscal Year: 2013
    ..to determine the efficacy of mycobacterial disease control programs, focusing on tuberculosis in humans and cattle and on leprosy in humans...
  62. Development of a Transfection System for Trypanosome Mitochondria
    Torsten Ochsenreiter; Fiscal Year: 2010
    ..Trypanosoma brucei is the causative agent of African human sleeping sickness and the wasting disease Nagana in cattle. The parasite developmentally regulates its mitochondrial function...
  63. Identification of factors contributing to group behavior in African Trypanosomes
    MIGUEL AUGUSTO LOPEZ; Fiscal Year: 2012
    ..a flagellated protozoan parasite that is the causative agent of African sleeping sickness in humans and nagana in cattle. Sleeping sickness is a reemerging disease in sub-Saharan Africa where ~60 million people live at risk of ..
  64. Missouri Food Safety Council Initiative
    LINDA HICKAM; Fiscal Year: 2013
    ..Missouri's agricultural diversity includes 107,825 farms, 3 million swine, over 3 million cattle, 4,448 egg retailers, 764 egg dealers, 8 processors, as well as 1,445 total permitted and licensed dairy farms, ..
  65. Characterization of de novo generation of infectious prions
    Joaquin Castilla; Fiscal Year: 2009
    ..e. Bovine spongiform encephalopathy (BSE) in US cattle and Nor98 (atypical scrapie) in New Zealand sheep, provide evidence that this infrequent spontaneous phenomenon ..
  66. TRYPANOSOME VARIANT SURFACE GLYCOPROTEIN CARBOHYDRATES
    Herman van Halbeek; Fiscal Year: 1993
    ..It presents a threat to man and drastically impedes effective cattle-rearing. The causative agents of this infectious disease are members of the genus Trypanosoma...
  67. GORDON CONFERENCE--BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2002
    ..including syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been difficult to study...
  68. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    JANIS WEIS; Fiscal Year: 2004
    ..including syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery. Historically, spirochetes have been difficult to study...
  69. MECHANISMS OF NEUROPATHOGENESIS IN BORNA DISEASE
    Mady Hornig; Fiscal Year: 2002
    ..Natural infection has been confirmed only in horses, sheep, cattle, birds, and cats; however, primates can be infected experimentally...
  70. MOLECULAR MECHANISMS OF MSP2 VARIATION IN RICKETTSIAE
    Anthony Barbet; Fiscal Year: 2007
    ..MSP2 was initially defined in Anaplasma marginale and infections of cattle and ticks with this pathogen provide an excellent model for discovering the mechanisms used to modify the surface ..
  71. Molecular Definition of Mycobacterium paratuberculosis
    JULIA INAMINE; Fiscal Year: 2005
    ..M. paratuberculosis is the etiological agent of Johne's disease, chronic granulomatous enteritis in cattle and other ruminants, and has been implicated as a possible cause of Crohn's disease in humans...
  72. Origin of Virulence Factors in African Trypanosomes
    ANDREW MCARTHUR; Fiscal Year: 2004
    ..that cause African sleeping sickness in humans while Trypanosoma brucei brucei causes a wasting disease in cattle called Nagana...
  73. GORDON CONFERENCE: BIOLOGY OF THE SPIROCHETES
    Steven Norris; Fiscal Year: 2000
    ..that cause syphilis, Lyme disease, relapsing fever, leptospirosis, periodontal disease, digital dermatitis of cattle, and swine and human dysentery...
  74. Intercellular transfer of prion in prion disease
    Man Sun Sy; Fiscal Year: 2006
    ..In animal TSE, such as scrapie in sheep and bovine spongiform encephalopathy (BSE) in cattle, it is believed that the PrP sc enters the host through the gastrointestinal tract, migrates to the spleen, and ..
  75. MARKERS OF HUMAN INFECTION WITH BOVINE LEUKEMIA VIRUS
    GERTRUDE BUEHRING; Fiscal Year: 2007
    ..Bovine leukemia virus (BLV), an oncogenic retrovirus, causes widespread infection of cattle globally...