rana pipiens

Summary

Summary: A highly variable species of the family Ranidae in Canada, the United States and Central America. It is the most widely used Anuran in biomedical research.

Top Publications

  1. ncbi Role for corticoids in mediating the response of Rana pipiens tadpoles to intraspecific competition
    Karen Ann Glennemeier
    Department of Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    J Exp Zool 292:32-40. 2002
  2. ncbi Partial life-cycle toxicity and bioconcentration modeling of perfluorooctanesulfonate in the northern leopard frog (Rana pipiens)
    Gerald T Ankley
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Environ Toxicol Chem 23:2745-55. 2004
  3. ncbi Agrochemicals increase trematode infections in a declining amphibian species
    Jason R Rohr
    Biology Department, University of South Florida, Tampa, Florida 33620, USA
    Nature 455:1235-9. 2008
  4. ncbi The architecture of active zone material at the frog's neuromuscular junction
    M L Harlow
    Department of Neurobiology, Stanford University School of Medicine, California 94305, USA
    Nature 409:479-84. 2001
  5. pmc The structural integrity exerted by N-terminal pyroglutamate is crucial for the cytotoxicity of frog ribonuclease from Rana pipiens
    You Di Liao
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    Nucleic Acids Res 31:5247-55. 2003
  6. ncbi Integration and recovery processes contribute to the temporal selectivity of neurons in the midbrain of the northern leopard frog, Rana pipiens
    T B Alder
    Department of Biology, University of Utah, Salt Lake City 84112 0840, USA
    J Comp Physiol A 186:923-37. 2000
  7. pmc In vivo confocal intrinsic optical signal identification of localized retinal dysfunction
    Qiu xiang Zhang
    Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Invest Ophthalmol Vis Sci 53:8139-45. 2012
  8. ncbi Tricaine (MS-222) is a safe anesthetic compound compared to benzocaine and pentobarbital to induce anesthesia in leopard frogs (Rana pipiens)
    Yavuz Cakir
    Department of Pathology, University of Alabama, Birmingham, AL 35294, USA
    Pharmacol Rep 57:467-74. 2005
  9. pmc Progesterone-induced changes in the phosphoryl potential during the meiotic divisions in amphibian oocytes: role of Na/K-ATPase
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    BMC Dev Biol 11:67. 2011
  10. pmc Live imaging of bulk endocytosis in frog motor nerve terminals using FM dyes
    Michael A Gaffield
    Department of Physiology and Biophysics, University of Colorado Denver, Anshutz Medical Campus, Aurora, CO 80045, USA
    J Neurophysiol 106:599-607. 2011

Research Grants

  1. STRUCTURE/FUNCTION OF MYOSIN IN SKELETAL MUSCLE
    Gordon Lutz; Fiscal Year: 2001
  2. DIVERSITY IN MEMBRANE PROPERTIES OF INNER EAR HAIR CELLS
    ELBA SERRANO; Fiscal Year: 1993
  3. BACTERIAL EXPRESSION OF LYMPHOMA RNRNASE IMMUNOTOXIN
    SHUI ON LEUNG; Fiscal Year: 1999
  4. The role of forelimb muscles in frog jumping
    Richard Essner; Fiscal Year: 2005
  5. DESIGN OF MUSCULAR SYSTEMS
    LAWRENCE ROME; Fiscal Year: 2003
  6. Dual Confocal Microscopic Scanner
    Eduardo Rios; Fiscal Year: 2008
  7. ELECTRICAL INJURY-- ELECTROCONFORMATION OF MEM PROTEINS
    Wei Chen; Fiscal Year: 2004
  8. EXCITATION-CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 2005
  9. FGF Regulation of GnRH Neurons
    Pei San Tsai; Fiscal Year: 2008
  10. FUNCTIONAL EVOLUTION OF OPIOID RECEPTORS
    Craig Stevens; Fiscal Year: 2007

Detail Information

Publications210 found, 100 shown here

  1. ncbi Role for corticoids in mediating the response of Rana pipiens tadpoles to intraspecific competition
    Karen Ann Glennemeier
    Department of Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
    J Exp Zool 292:32-40. 2002
    ..To test this hypothesis, we measured whole-body corticosterone content in premetamorphic Leopard frog (Rana pipiens) tadpoles raised at two different population densities and three different food levels...
  2. ncbi Partial life-cycle toxicity and bioconcentration modeling of perfluorooctanesulfonate in the northern leopard frog (Rana pipiens)
    Gerald T Ankley
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Environ Toxicol Chem 23:2745-55. 2004
    ..Therefore, we evaluated the effects of PFOS on survival and development of the northern leopard frog (Rana pipiens) from early embryogenesis through complete metamorphosis...
  3. ncbi Agrochemicals increase trematode infections in a declining amphibian species
    Jason R Rohr
    Biology Department, University of South Florida, Tampa, Florida 33620, USA
    Nature 455:1235-9. 2008
    ..candidates) of the abundance of larval trematodes (parasitic flatworms) in the declining northern leopard frog Rana pipiens. The effects of atrazine were consistent across trematode taxa...
  4. ncbi The architecture of active zone material at the frog's neuromuscular junction
    M L Harlow
    Department of Neurobiology, Stanford University School of Medicine, California 94305, USA
    Nature 409:479-84. 2001
    ..The structural linkage may include proteins that mediate the calcium-triggered exocytosis of neurotransmitter by the synaptic vesicles during synaptic transmission...
  5. pmc The structural integrity exerted by N-terminal pyroglutamate is crucial for the cytotoxicity of frog ribonuclease from Rana pipiens
    You Di Liao
    Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
    Nucleic Acids Res 31:5247-55. 2003
    Onconase, a cytotoxic ribonuclease from Rana pipiens, possesses pyroglutamate (Pyr) at the N-terminus and has a substrate preference for uridine-guanine (UG)...
  6. ncbi Integration and recovery processes contribute to the temporal selectivity of neurons in the midbrain of the northern leopard frog, Rana pipiens
    T B Alder
    Department of Biology, University of Utah, Salt Lake City 84112 0840, USA
    J Comp Physiol A 186:923-37. 2000
    ..Single units were recorded extracellularly in the torus semicircularis of the northern leopard frog, Rana pipiens. Two physiologically distinct classes of neurons were identified, based on their response latencies and their ..
  7. pmc In vivo confocal intrinsic optical signal identification of localized retinal dysfunction
    Qiu xiang Zhang
    Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Invest Ophthalmol Vis Sci 53:8139-45. 2012
    ....
  8. ncbi Tricaine (MS-222) is a safe anesthetic compound compared to benzocaine and pentobarbital to induce anesthesia in leopard frogs (Rana pipiens)
    Yavuz Cakir
    Department of Pathology, University of Alabama, Birmingham, AL 35294, USA
    Pharmacol Rep 57:467-74. 2005
    ..on the physiological changes, heart rate and ECG (electrocardiogram) parameters in the leopard frog, Rana pipiens. Loss of righting reflex (RR), loss of pain response (NR = nociceptor response) and recovery time were measured...
  9. pmc Progesterone-induced changes in the phosphoryl potential during the meiotic divisions in amphibian oocytes: role of Na/K-ATPase
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    BMC Dev Biol 11:67. 2011
    Progesterone triggers resumption of the first meiotic division in the Rana pipiens oocyte by binding to the N-terminal external loop of the catalytic subunit of Na/K-ATPase, releasing a cascade of lipid second messengers...
  10. pmc Live imaging of bulk endocytosis in frog motor nerve terminals using FM dyes
    Michael A Gaffield
    Department of Physiology and Biophysics, University of Colorado Denver, Anshutz Medical Campus, Aurora, CO 80045, USA
    J Neurophysiol 106:599-607. 2011
    ....
  11. ncbi Regional decline of an iconic amphibian associated with elevation, land-use change, and invasive species
    Pieter T J Johnson
    Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309, USA
    Conserv Biol 25:556-66. 2011
    ..Our results highlight the importance of considering multiple, competing hypotheses to explain species declines, particularly when implicated factors operate at different spatial extents...
  12. pmc Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens)
    L Ramakrishnan
    Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305 5402, USA
    Infect Immun 65:767-73. 1997
    ..Here, we describe a laboratory animal model for M. marinum disease in the leopard frog (Rana pipiens), a natural host species. M. marinum causes a chronic granulomatous, nonlethal disease in immunocompetent frogs...
  13. pmc Amplitude distribution of calcium sparks in confocal images: theory and studies with an automatic detection method
    H Cheng
    Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Biophys J 76:606-17. 1999
    ..In addition, we discuss possible situations when a modal distribution might be observed...
  14. pmc Context-dependent effects of ranaviral infection on northern leopard frog life history traits
    Pierre Echaubard
    Genetics and Ecology of Amphibians Research Group, Department of Biology, Laurentian University, Sudbury, Canada
    PLoS ONE 5:e13723. 2010
    ..In a factorial experiment, we exposed Northern leopard frog (Lithobates pipiens, formerly Rana pipiens) tadpoles to different concentrations of Ranavirus and investigated the effect of host density on certain life-..
  15. pmc Low levels of the herbicide atrazine alter sex ratios and reduce metamorphic success in Rana pipiens tadpoles raised in outdoor mesocosms
    Valérie S Langlois
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    Environ Health Perspect 118:552-7. 2010
    ..There are conflicting reports regarding the effects of atrazine (ATZ) on amphibian development. Therefore, further studies are needed to examine the potential mechanisms of action of ATZ in amphibians...
  16. ncbi Atrazine is an immune disruptor in adult northern leopard frogs (Rana pipiens)
    Marc A Brodkin
    Department of Biology, Science Division, Widener University, One University Place, Chester, Pennsylvania 19013, USA
    Environ Toxicol Chem 26:80-4. 2007
    ..Exposure to atrazine (21 ppb for 8 d) affects the innate immune response of adult Rana pipiens in similar ways to acid exposure (pH 5.5), as we have previously shown...
  17. pmc Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes
    W Ardelt
    Alfacell Corporation, 300 Atrium Drive, Somerset, NJ 08873, USA
    Curr Pharm Biotechnol 9:215-25. 2008
    b>Rana pipiens oocytes contain two homologues of pancreatic ribonuclease A that are cytostatic and cytotoxic to human cancer cells...
  18. pmc Confocal imaging of [Ca2+] in cellular organelles by SEER, shifted excitation and emission ratioing of fluorescence
    Bradley S Launikonis
    Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University School of Medicine, 1750 W Harrison St Suite 1279JS, Chicago, IL 60612, USA
    J Physiol 567:523-43. 2005
    ..While the increase of [Ca2+]SR was limited by loss through Ca2+ release channels, its decrease in low [Ca2+]cyto was largely dependent on leaks through the SR Ca2+ pump...
  19. ncbi Rearing density and susceptibility of Rana pipiens metamorphs to cercariae of a digenetic trematode
    Oluwayemisi K Dare
    Department of Biology, Carleton University, Ottawa, Ontario, Canada
    J Parasitol 92:543-7. 2006
    ..We investigated the degree to which rearing density of Rana pipiens larvae influenced time to metamorphosis and snout-to-vent length and mass at metamorphosis, as well as ..
  20. pmc Calcium release flux underlying Ca2+ sparks of frog skeletal muscle
    E Rios
    Department of Molecular Biophysics and Physiology, Rush University, Chicago, Illinois 60612, USA
    J Gen Physiol 114:31-48. 1999
    ..Correspondingly, the algorithm reported greater spatial extent of the source for real sparks. This may again indicate a multichannel origin of sparks, or could reflect limitations in spatial resolution...
  21. pmc The spark and its ember: separately gated local components of Ca(2+) release in skeletal muscle
    A Gonzalez
    Department of Molecular Biophysics and Physiology, Rush University, Chicago, Illinois 60612, USA
    J Gen Physiol 115:139-58. 2000
    ....
  22. ncbi Uptake and elimination of naphthalene from liver, lung, and muscle tissue in the leopard frog (Rana pipiens)
    Erich K Stabenau
    Department of Biology, Bradley University, Peoria, Illinois, USA
    J Environ Sci Health A Tox Hazard Subst Environ Eng 41:1449-61. 2006
    ..of a 0-12-hour naphthalene exposure on pulmonary CO(2) excretion and bioaccumulation in the leopard frog, Rana pipiens, were investigated...
  23. ncbi Immunosuppression in the northern leopard frog (Rana pipiens) induced by pesticide exposure
    Mary Kate Gilbertson
    Great Lakes Institute for Environmental Research, Department of Biological Sciences, University of Windsor, Windsor, Ontario N9B 3P4, Canada
    Environ Toxicol Chem 22:101-10. 2003
    ..that environmental xenobiotics have the potential to alter the immune function of northern leopard frogs (Rana pipiens)...
  24. ncbi Apoptosis in the digestive tract of herbivorous Rana pipiens larvae and carnivorous Ceratophrys ornata larvae: an immunohistochemical study
    Jane C Kaltenbach
    Department of Biological Sciences, Mount Holyoke College, South Hadley, Massachusetts 01075, USA
    J Morphol 273:103-8. 2012
    The lifespan of herbivorous Rana pipiens larvae is ∼3 months, while that of carnivorous Ceratophrys ornata larvae is only about 2 weeks. During metamorphic climax, the larval gut shortens dramatically, especially in R...
  25. ncbi Small changes in whole-body corticosterone content affect larval Rana pipiens fitness components
    Karen Ann Glennemeier
    Department of Biology, 3065C Natural Science Building, University of Michigan, Ann Arbor 48109 1048, USA
    Gen Comp Endocrinol 127:16-25. 2002
    ..In the current study, we exposed pre-metamorphic Rana pipiens tadpoles to moderate doses (62 and 125 nM) of exogenous corticosterone by adding it to the rearing water...
  26. ncbi Growth of the pectoral girdle of the Leopard frog, Rana pipiens (Anura: Ranidae)
    Rebecca M Shearman
    University of Chicago, Department of Organismal Biology and Anatomy, Chicago, Illinois 60637, USA
    J Morphol 264:94-104. 2005
    This article describes the growth of the anuran pectoral girdle of Rana pipiens and compares skeletal development of the shoulder to that of long bones. The pectoral girdle chondrifies as two halves, each adjacent to a developing humerus...
  27. ncbi Assessment of the risk of solar ultraviolet radiation to amphibians. I. Dose-dependent induction of hindlimb malformations in the northern leopard frog (Rana pipiens)
    Gerald T Ankley
    U S Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Environ Sci Technol 36:2853-8. 2002
    ..in a species in which this phenomenon seemingly is particularly prevalent, the northern leopard frog (Rana pipiens)...
  28. pmc Comparison of simulated and measured calcium sparks in intact skeletal muscle fibers of the frog
    S M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Gen Physiol 120:349-68. 2002
    ..Under the assumption that the single channel Ca(2+) current of a ryanodine receptor (RYR) is 0.5-2 pA, the results suggest that 1-5 active RYRs generate an average Ca(2+) spark in a frog intact muscle fiber...
  29. ncbi Estrogenic exposure affects metamorphosis and alters sex ratios in the northern leopard frog (Rana pipiens): identifying critically vulnerable periods of development
    Natacha S Hogan
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ont, Canada
    Gen Comp Endocrinol 156:515-23. 2008
    ..to identify sensitive developmental periods for estrogenic endocrine disruption in the northern leopard frog (Rana pipiens) using short, targeted exposures to the synthetic estrogen, ethinylestradiol (EE2)...
  30. ncbi Chronic exposure of Rana pipiens tadpoles to UVB radiation and the estrogenic chemical 4-tert-octylphenol
    Maxine C Croteau
    Department of Biology, University of Ottawa, Centre for Advanced Research in Environmental Genomics, Ottawa, Ontario, Canada
    J Toxicol Environ Health A 71:134-44. 2008
    ..4-tert-octylphenol (OP), alone and in combination, on the survival, development, growth, and metamorphosis of Rana pipiens (northern leopard frog) tadpoles are evaluated...
  31. pmc Type 3 ryanodine receptors of skeletal muscle are segregated in a parajunctional position
    Edward Felder
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    Proc Natl Acad Sci U S A 99:1695-700. 2002
    ..On the basis of these two observations, we postulate that RyR3s are restricted to the parajunctional region, and thus their activation must be indirect and derivative during excitation-contraction coupling...
  32. ncbi Impacts of agriculture on the parasite communities of northern leopard frogs (Rana pipiens) in southern Quebec, Canada
    K C King
    Department of Biology, Concordia University, Montreal, Quebec, Canada H3G 1M8
    Parasitology 134:2063-80. 2007
    ..Community composition was associated with dissolved organic carbon and conductivity, but few links were found with pesticides. Pollution effects may be masked by a strong impact of land use on parasite transmission...
  33. ncbi Lethal and sublethal effects of chronic cadmium exposure on northern leopard frog (Rana pipiens) tadpoles
    Jackson A Gross
    Department of Animal Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Environ Toxicol Chem 26:1192-7. 2007
    ..We exposed embryos and tadpoles of northern leopard frogs (Rana pipiens) to Cd (control, 0.25, 5.0, and 20...
  34. ncbi Amphibian ryanodine receptor isoforms are related to those of mammalian skeletal or cardiac muscle
    F A Lai
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill 27599 7260
    Am J Physiol 263:C365-72. 1992
    ..These results suggest that amphibian skeletal muscle expresses two distinct RyR isoforms that share epitopes in common with the mammalian skeletal or cardiac RyR...
  35. ncbi Physiological and morphological correlates of among-individual variation in standard metabolic rate in the leopard frog Rana pipiens
    Anthony C Steyermark
    Department of Biology, University of St Thomas, St Paul, MN 55105, USA
    J Exp Biol 208:1201-8. 2005
    ..Other conditions, such as high resource availability, may favor individuals with a high SMR, through large organ size, or high thyroxine or mitochondrial content...
  36. pmc A repetitive mode of activation of discrete Ca2+ release events (Ca2+ sparks) in frog skeletal muscle fibres
    M G Klein
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201
    J Physiol 515:391-411. 1999
    ..channel or a small cluster of such channels that act as a release unit, have been measured in single, frog (Rana pipiens) skeletal muscle fibres. 2...
  37. ncbi Amelogenin sequence and enamel biomineralization in Rana pipiens
    Xinping Wang
    Department of Oral Biology and Allan G Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Exp Zool B Mol Dev Evol 304:177-86. 2005
    ..to start elucidating the structure and function of amelogenins in the evolution of enamel, the leopard frog (Rana pipiens) was used as a model...
  38. ncbi Androgen effects on tyrosine hydroxylase cells in the northern leopard frog, Rana pipiens
    Joanne Chu
    Department of Zoology, Oregon State University, Corvallis, OR 97331, USA
    Neuroendocrinology 76:18-27. 2002
    ..DHT) on changes in tyrosine hydroxylase immunoreactive (TH-ir) neuron number in the fore- and midbrain of male Rana pipiens, the Northern leopard frog, using a whole-mount immunohistochemical procedure...
  39. ncbi Sex differences and hormone influences on tyrosine hydroxylase immunoreactive cells in the leopard frog
    Walter Wilczynski
    Department of Psychology, University of Texas at Austin, 4 212 Seay Psychology Buliding, 108 E Dean Keaton, Austin, Texas 78712, USA
    J Neurobiol 56:54-65. 2003
    ..suprachiasmatic nucleus (SCN), posterior tuberculum (TP), and caudal hypothalamus (Hy) in the leopard frog (Rana pipiens), in addition to the effects of natural variation in sex steroid hormones on these same populations in both ..
  40. ncbi Sublethal effects of chronic exposure to an organochlorine compound on northern leopard frog (Rana pipiens) tadpoles
    K A Glennemeler
    Department of Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Environ Toxicol 16:287-97. 2001
    ..In the current study, northern leopard frog (Rana pipiens) tadpoles were chronically exposed to a polychlorinated biphenyl (PCB) congener, 77-TCB, and effects on ..
  41. ncbi Caveolin-Na/K-ATPase interactions: role of transmembrane topology in non-genomic steroid signal transduction
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Steroids 77:1160-8. 2012
    ..Progesterone binding to the α-subunit may thus facilitate CB motif:CAV-1 interaction, which in turn induces helix-helix interaction and generates both a signaling cascade and formation of polar steroids...
  42. ncbi Effects of wetland vs. landscape variables on parasite communities of Rana pipiens: links to anthropogenic factors
    Anna M Schotthoefer
    College of Veterinary Medicine, University of Illinois, 2001 South Lincoln Avenue, Urbana, Illinois 61802, USA
    Ecol Appl 21:1257-71. 2011
    ..determine risks of parasitism in frogs, helminth communities in metamorphic frogs of the northern leopard frog (Rana pipiens) were examined in relation to wetland and landscape factors at local (1 km) and regional (10 km) spatial ..
  43. ncbi The developmental effects of a municipal wastewater effluent on the northern leopard frog, Rana pipiens
    Anthony D Sowers
    Institute of Environmental Toxicology, Department of Biological Sciences, Clemson University, 509 Westinghouse Road, Pendleton, SC 29670, USA
    Aquat Toxicol 94:145-52. 2009
    ..to characterize the developmental and behavioral effects of such a complex mixture, northern leopard frogs, Rana pipiens, were exposed to a range of concentrations (0%, 10%, 50%, 100%) of municipal wastewater effluent from the egg ..
  44. ncbi Transmitter release from Rana pipiens vestibular hair cells via mGluRs: a role for intracellular Ca(++) release
    Adam W Hendricson
    Division of Pharmacology Toxicology, University of Texas at Austin College of Pharmacy, 2409 University Ave, PHR 5 214, Austin, TX 78712, USA
    Hear Res 172:99-109. 2002
    ....
  45. ncbi Induction of hepatic cytochrome P-450 by phenobarbital in semi-aquatic frog (Rana pipiens)
    M A Khan
    Department of Biological Sciences, University of Illinois at Chicago 60607 7060, USA
    Biochem Biophys Res Commun 244:737-44. 1998
    ..form, a CYPIIB gene product) can be induced by pentobarbital (PB) in the adults of the semiaquatic frog, Rana pipiens (as in other terrestrial vertebrates), but not in adults of the aquatic frog Xenopus laevis or in bluegill ..
  46. pmc The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells
    Csaba Miskey
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    Nucleic Acids Res 31:6873-81. 2003
    ..method was used to isolate uninterrupted transposase coding regions from the genome of the frog species Rana pipiens. The isolated clones were approximately 90% identical to a predicted transposase gene sequence from Xenopus ..
  47. pmc Calcium sparks in intact skeletal muscle fibers of the frog
    S Hollingworth
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6085, USA
    J Gen Physiol 118:653-78. 2001
    ..51 microm in z. Observations were made at 17-20 degrees C on fibers from Rana pipiens and Rana temporaria. Fibers were studied in two external solutions: normal Ringer's ([K(+)] = 2...
  48. ncbi Changes in selected aspects of immune function in the leopard frog, Rana pipiens, associated with exposure to cold
    G D Maniero
    Department of EPO Biology, University of Colorado, Boulder 80309, USA
    J Comp Physiol B 167:256-63. 1997
    ..proliferation, leukocyte populations, and serum complement levels was examined in the northern leopard frog, Rana pipiens. Proliferation of T lymphocytes in response to phytohemagglutinin stimulation was significantly decreased in ..
  49. ncbi Optical dissection of stimulus-evoked retinal activation
    Xin Cheng Yao
    Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Opt Express 16:12446-59. 2008
    ..Fast CMOS imaging disclosed rapid IOSs within 5 ms after the stimulus onset, and both ON and OFF optical responses were observed associated with a step light stimulus...
  50. ncbi Progesterone and subsequent polar metabolites are essential for completion of the first meiotic division in amphibian oocytes
    Adele B Kostellow
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Mol Cell Endocrinol 291:50-6. 2008
    We find that completion of the first meiotic division in Rana pipiens oocytes requires the sequential action of at least two steroids: progesterone and one or more subsequent polar metabolites of progesterone...
  51. pmc Depletion "skraps" and dynamic buffering inside the cellular calcium store
    Bradley S Launikonis
    Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University, 1750 West Harrison Street, Suite 1279JS, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 103:2982-7. 2006
    ..When store depletion becomes widespread, the polymers would collapse to increase store [Ca2+] and sustain the concentration gradient that drives release flux...
  52. ncbi Experimental infection of Rana pipiens tadpoles with Echinostoma trivolvis cercariae
    B Fried
    Department of Biology, Lafayette College, Easton, PA 18042, USA
    Parasitol Res 83:666-9. 1997
    Studies were done on laboratory-raised Rana pipiens tadpoles experimentally infected with Echinostoma trivolvis cercariae. Tadpoles exposed individually to 250 cercariae died within 24 h...
  53. pmc Progesterone binding to the alpha1-subunit of the Na/K-ATPase on the cell surface: insights from computational modeling
    Gene A Morrill
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Steroids 73:27-40. 2008
    ..Analysis of [(3)H]ouabain and [(3)H]progesterone binding to the plasma membrane of the Rana pipiens oocyte indicates that progesterone competes with ouabain for a low affinity ouabain binding site on a 112kDa ..
  54. pmc Pesticide mixtures, endocrine disruption, and amphibian declines: are we underestimating the impact?
    Tyrone B Hayes
    Laboratory for Integrative Studies in Amphibian Biology, Department of Integrative Biology, Museum of Vertebrate Zoology, Group in Endocrinology, University of California, Berkeley, California 94720 3140, USA
    Environ Health Perspect 114:40-50. 2006
    ..We examined larval growth and development, sex differentiation, and immune function in leopard frogs (Rana pipiens)...
  55. pmc Octylphenol and UV-B radiation alter larval development and hypothalamic gene expression in the leopard frog (Rana pipiens)
    Douglas Crump
    Department of Biology and Centre for Advanced Research in Environmental Genomics, University of Ottawa, 30 Marie Curie Street, Ottawa, Ontario, K1N 6N5, Canada
    Environ Health Perspect 110:277-84. 2002
    ..for their effects on hypothalamic gene expression and premetamorphic development in the leopard frog Rana pipiens. Newly hatched tadpoles were exposed for 10 days to OP alone at two different dose levels; to subambient UV-B ..
  56. pmc Prevalence of the pathogenic chytrid fungus, Batrachochytrium dendrobatidis, in an endangered population of northern leopard frogs, Rana pipiens
    Maarten J Voordouw
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada
    BMC Ecol 10:6. 2010
    ..Chytridiomycosis, an emerging infectious disease of amphibians, is caused by the pathogenic fungus Batrachochytrium dendrobatidis (Bd) and has been linked to global declines in amphibians...
  57. ncbi Changes in brain-derived neurotrophic factor and trkB receptor in the adult Rana pipiens retina and optic tectum after optic nerve injury
    Mildred V Duprey-Díaz
    Institute of Neurobiology and Department of Anatomy, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico 00901
    J Comp Neurol 454:456-69. 2002
    ..neurotrophic factor (BDNF) and its receptor tyrosine kinase (trkB) in retina and optic tectum of the frog Rana pipiens during regeneration after axotomy. We also measured changes in BDNF mRNA in retina and tectum...
  58. pmc How source content determines intracellular Ca2+ release kinetics. Simultaneous measurement of [Ca2+] transients and [H+] displacement in skeletal muscle
    Gonzalo Pizarro
    Dept of Molecular Biophysics and Physiology, Rush University School of Medicine, 1750 W Harrison St, Suite 1279JS, Chicago, IL 60612, USA
    J Gen Physiol 124:239-58. 2004
    ..e., a slower inactivation of Ca(2+) release). These results are consistent with a major inhibitory effect of cytosolic (rather than intra-SR) Ca(2+) on the activity of Ca(2+) release channels...
  59. ncbi Effects of steroid hormones on spermatogenesis and GnRH release in male Leopard frogs, Rana pipiens
    Pei San Tsai
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    Gen Comp Endocrinol 134:330-8. 2003
    ..and DHT administration on the in vitro release of GnRH and on the spermatogenesis of adult male leopard frog, Rana pipiens. R...
  60. ncbi Calcium sparks in skeletal muscle fibers
    Stephen M Baylor
    Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, 19104 6085, USA
    Cell Calcium 37:513-30. 2005
    ..A major goal of future experiments is to estimate this number more precisely and, if it is two or more, to investigate the communication mechanism that allows multiple RYRs to be co-activated in a rapid but self-limited fashion...
  61. pmc The changes in Ca2+ sparks associated with measured modifications of intra-store Ca2+ concentration in skeletal muscle
    Bradley S Launikonis
    Section of Cellular Signaling, Department of Molecular Biophysics and Physiology, Rush University, Chicago, IL 60612, USA
    J Gen Physiol 128:45-54. 2006
    ....
  62. pmc Activation of Ca2+ release by caffeine and voltage in frog skeletal muscle
    N Shirokova
    Department of Molecular Biophysics and Physiology, Rush University, School of Medicine, Chicago, IL 60612, USA N Shirokova
    J Physiol 493:317-39. 1996
    ....
  63. ncbi The steroid-binding subunit of the Na/K-ATPase as a progesterone receptor on the amphibian oocyte plasma membrane
    Gene A Morrill
    Department of Physiology and Biophysics, Yeshiva University, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Steroids 70:933-45. 2005
    ..Progesterone may thus act in part through the plasma membrane Na/K-ATPase signaling system...
  64. ncbi Expression and characterization of a Rana pipiens amelogenin protein
    T G H Diekwisch
    Department of Oral Biology and Allan G Brodie Laboratory for Craniofacial Genetics, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Eur J Oral Sci 114:86-92; discussion 93-5, 379-80. 2006
    ..Here we report, for the first time, amphibian amelogenin recombinant protein expression and characterization in Rana pipiens. In order to characterize R...
  65. pmc Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): laboratory and field evidence
    Tyrone Hayes
    Laboratory for Integrative Studies in Amphibian Biology, Group in Endocrinology, Museum of Vertebrate Zoology, and Department of Integrative Biology, University of California, Berkeley, California 94720, USA
    Environ Health Perspect 111:568-75. 2003
    ..retarded gonadal development (gonadal dysgenesis) and testicular oogenesis (hermaphroditism) in leopard frogs (Rana pipiens). Slower developing males even experienced oocyte growth (vitellogenesis)...
  66. ncbi Nucleus isthmi enhances calcium influx into optic nerve fiber terminals in Rana pipiens
    Elizabeth A Dudkin
    Division of Science, Commonwealth College, Pennsylvania State University, 25 Yearsley Mill Road, Media, PA 19063, USA
    Brain Res 969:44-52. 2003
    ..These results suggest that nucleus isthmi input can facilitate retinotectal neurotransmission, and the mechanism could be used to allow the frog to attend to a single prey stimulus in an environment of several prey stimuli...
  67. pmc Simulation of calcium sparks in cut skeletal muscle fibers of the frog
    W K Chandler
    Department of Cellular and Molecular Physiology, Yale Universtiy School of Medicine, New Haven, CT 06520, USA
    J Gen Physiol 121:311-24. 2003
    ..These results indicate that the gating of RYRs, or their apparent single channel Ca2+ flux, is different in frog cut fibers--and, perhaps, in other disrupted preparations--than in intact fibers...
  68. ncbi Acid exposure is an immune disruptor in adult Rana pipiens
    Itzick Vatnick
    Department of Biology, Science Division, Widener University, One University Place, Chester, Pennsylvania 19013, USA
    Environ Toxicol Chem 25:199-202. 2006
    ..effect of an acidic environment on innate immune system function under controlled experimental conditions in Rana pipiens. We developed an in vivo assay, by injecting a suspension of 1-microm fluorescent beads in fluid thioglycollate,..
  69. pmc Regulation of Ca2+ sparks by Ca2+ and Mg2+ in mammalian and amphibian muscle. An RyR isoform-specific role in excitation-contraction coupling?
    Jingsong Zhou
    Department of Molecular Biophysics and Physiology, Rush University, Chicago, IL 60612, USA
    J Gen Physiol 124:409-28. 2004
    ..It is proposed that relief of this inhibition could be the mechanism by which increased SR load increases spark frequency...
  70. ncbi Effects of nitrate and atrazine on larval development and sexual differentiation in the northern leopard frog Rana pipiens
    Frances Orton
    School of Biological Sciences, University of Plymouth, Plymouth, Devon PL4 8AA, United Kingdom
    Environ Toxicol Chem 25:65-71. 2006
    ..Histological evidence suggests that premature maturation of gonad may occur as a result of nitrate and/or atrazine exposure during larval development...
  71. pmc Effects of azumolene on Ca2+ sparks in skeletal muscle fibers
    Yingfan Zhang
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N Greene St, Baltimore, MD 21201, USA
    J Pharmacol Exp Ther 314:94-102. 2005
    ..We conclude that azumolene suppresses the opening rate but not the open time of RyR Ca2+ release channels within skeletal fibers...
  72. pmc Concerted vs. sequential. Two activation patterns of vast arrays of intracellular Ca2+ channels in muscle
    Jinsong Zhou
    Section of Cellular Signaling, Rush University, Chicago, IL 60612, USA
    J Gen Physiol 126:301-9. 2005
    ..Concerted opening instead appears to be a property of RyR alpha in the amphibian and the homologous isoform 1 in the mammal...
  73. ncbi Effects of agricultural pesticides on the immune system of Rana pipiens and on its resistance to parasitic infection
    Marie Soleil Christin
    INRS Institut Armand Frappier Santé humaine, 245 Hymus Boulevard, Pointe Claire, Quebec H9R 1G6, Canada
    Environ Toxicol Chem 22:1127-33. 2003
    ..In this study, juvenile leopard frogs (Rana pipiens) were exposed for 21 d to a mixture of six pesticides (atrazine, metribuzin, aldicarb, endosulfane, lindane, ..
  74. ncbi ATPase and MHC class II molecules co-expression in Rana pipiens dendritic cells
    A E Castell-Rodríguez
    Departamento de Biologia Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México DF, Mexico
    Dev Comp Immunol 23:473-85. 1999
    ..Some ATPase-positive dendritic cells showed co-expression of class II molecules. These results suggest the existence of dendritic cell subsets in amphibians as is clearly demonstrated in mammals...
  75. ncbi Level dependence of distortion product otoacoustic emissions in the leopard frog, Rana pipiens pipiens
    Sebastiaan W F Meenderink
    Institute for Brain and Behaviour, Maastricht University, The Netherlands
    Hear Res 192:107-18. 2004
    ..This quantitative difference between the low-level slopes for DPOAEs from the AP and the BP may signify the involvement of different mechanisms in low-level DPOAE generation for the two papillae, respectively...
  76. ncbi Effects of agricultural pesticides on the immune system of Xenopus laevis and Rana pipiens
    M S Christin
    INRS Institut Armand Frappier Santé humaine, 245 Hymus Blvd, Pointe Claire, Que, Canada H9R 1G6
    Aquat Toxicol 67:33-43. 2004
    ..In this study, we exposed two frog species, Xenopus laevis and Rana pipiens, for a short period of time to a mixture of pesticides (atrazine, metribuzine, endosulfan, lindane, aldicarb ..
  77. ncbi Stimulus frequency otoacoustic emissions in the Northern leopard frog, Rana pipiens pipiens: implications for inner ear mechanics
    Sebastiaan W F Meenderink
    University of California, Department of Physiological Science, 621 Charles E Youngdrive S, Los Angeles, CA 90095 1606, United States
    Hear Res 220:67-75. 2006
    ..are emissions thought to arise via linear coherent reflection, from an amphibian (the Northern leopard frog, Rana pipiens pipiens)...
  78. ncbi Hormone cross-regulation in the tadpole brain: developmental expression profiles and effect of T3 exposure on thyroid hormone- and estrogen-responsive genes in Rana pipiens
    Natacha S Hogan
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, Canada K1N 6N5
    Gen Comp Endocrinol 154:5-15. 2007
    ..changes in thyroid hormone receptors (TRalpha and TRbeta) and the estrogen receptor (ERalpha) in the brain of Rana pipiens throughout metamorphosis and in response to 48 h waterborne triiodothyronine (T3) exposure (0.5, 5 and 50 nM)...
  79. ncbi Physiological vulnerability of distortion product otoacoustic emissions from the amphibian ear
    Pim van Dijk
    Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Acoust Soc Am 114:2044-8. 2003
    ..vulnerability of distortion product otoacoustic emissions (DPOAEs) was investigated in the leopard frog, Rana pipiens pipiens. For each frog, DPOAEs were recorded from the amphibian and the basilar papillae...
  80. pmc Detailed f1, f2 area study of distortion product otoacoustic emissions in the frog
    Sebastiaan W F Meenderink
    Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Maastricht, 5800, 6202 AZ, Maastricht, The Netherlands
    J Assoc Res Otolaryngol 6:37-47. 2005
    ..It indicates that DPOAEs generated by neither papilla agree with the two-mechanism traveling wave model. This confirms our expectation for the BP and does not support the hypothesized presence of a mechanical traveling wave in the AP...
  81. pmc Unitary Ca2+ current through mammalian cardiac and amphibian skeletal muscle ryanodine receptor Channels under near-physiological ionic conditions
    Claudia Kettlun
    Department of Physiology, Loyola University Chicago, 2160 S First Ave, Maywood, IL 60153, USA
    J Gen Physiol 122:407-17. 2003
    ....
  82. ncbi Enzymatic and structural characterisation of amphinase, a novel cytotoxic ribonuclease from Rana pipiens oocytes
    Umesh P Singh
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Mol Biol 371:93-111. 2007
    Besides Onconase (ONC) and its V11/N20/R103-variant, oocytes of the Northern Leopard frog (Rana pipiens) contain another homologue of ribonuclease A, which we named Amphinase (Amph)...
  83. ncbi Comparison between distortion product otoacoustic emissions and nerve fiber responses from the basilar papilla of the frog
    Sebastiaan W F Meenderink
    Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, and Institute for Brain and Behavior, Maastricht University, The Netherlands
    J Acoust Soc Am 117:3165-73. 2005
    ..For larger stimulus frequency ratios, DPOAE recordings clearly deviate from model predictions. These differences are most likely caused by the oversimplified representation of the frog BP by the model...
  84. ncbi Effects of cannabinoids on synaptic transmission in the frog neuromuscular junction
    Enrique Sanchez-Pastor
    Unidad de Investigación Enrico Stefani del Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Av 25 de Julio 965, Colonia Villa San Sebastián, Apartado Postal 11, C P 28000 Colima, Colima, Mexico
    J Pharmacol Exp Ther 321:439-45. 2007
    ..study aimed to investigate the function of the cannabinoid receptor in the neuromuscular junction of the frog (Rana pipiens)...
  85. ncbi Exposure of leopard frogs to a pesticide mixture affects life history characteristics of the lungworm Rhabdias ranae
    A D Gendron
    St Lawrence Centre, Environment Canada, 105 McGill Street, 7th Floor, H2Y 2E7, Montreal, QC, Canada
    Oecologia 135:469-76. 2003
    We tested the hypothesis that exposure of leopard frogs ( Rana pipiens) to agricultural pesticides can affect the infection dynamics of a common parasite of ranid frogs, the lungworm Rhabdias ranae...
  86. pmc Intracellular Ca(2+) release as irreversible Markov process
    Juliana Rengifo
    Department of Molecular Biophysics and Physiology, Rush University, 1750 W Harrison Street, Chicago, IL 60612, USA
    Biophys J 83:2511-21. 2002
    ..Q., L.-S. Song, L. Xu, G. Meissner, E. G. Lakatta, E. Ríos, M. D. Stern, and H. Cheng. 2002. Biophys. J. 83:242-251) exemplify a cell-wide oscillation caused by coupling between ion permeation and channel gating...
  87. ncbi Amphibian declines. Conflict brewing over herbicide's link to frog deformities
    Rebecca Renner
    Science 298:938-9. 2002
  88. ncbi Immunohistochemical localization of cytochrome P4501A induced by 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in multiple organs of northern leopard frogs, Rana pipiens
    Y W Huang
    Department of Zoology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Environ Toxicol Chem 20:191-7. 2001
    ..In skin, mild staining was seen in epithelial cells of mucous glands and serous glands and in vascular endothelium, demonstrating induction of CYP1A in the dermal layer...
  89. pmc A preferred amplitude of calcium sparks in skeletal muscle
    E Rios
    Department of Molecular Biophysics and Physiology, Rush University, 1750 W Harrison Street, Suite 1279 JS, Chicago, Illinois 60612, USA
    Biophys J 80:169-83. 2001
    ..Channel groups, instead, could cooperate allosterically or through their calcium sensitivity, and give rise to a stereotyped amplitude in their collective spark...
  90. pmc The pattern of stimulation influences the amount of oscillatory work done by frog muscle
    E D Stevens
    Department of Zoology, University of Guelph, Ontario, Canada
    J Physiol 494:279-85. 1996
    ..e. a triplet. 6. The results of the present study imply that doublet stimulation patterns may be important to reduce the fatigue that occurs during artificial neuromuscular stimulation of skeletal muscle...
  91. ncbi Spontaneous otoacoustic emissions in seven frog species
    P van Dijk
    ENT Department, Audiology, University Hospital, Groningen, The Netherlands
    Hear Res 101:102-12. 1996
    ..Hyla cinerea, n = 10 ears; Hyla chrysoscelis, n = 10; Hyla versicolor, n = 7; Leptodactylus albilabris, n = 2; Rana pipiens pipiens, n = 8), and two primitive frog species (Xenopus laevis, n = 9; Bombina orientalis, n = 12)...
  92. pmc Reduction of calcium inactivation of sarcoplasmic reticulum calcium release by fura-2 in voltage-clamped cut twitch fibers from frog muscle
    D S Jong
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510 8026
    J Gen Physiol 102:333-70. 1993
    Cut fibers from Rana temporaria and Rana pipiens (striation spacing, 3.9-4.2 microns) were mounted in a double Vaseline-gap chamber and studied at 14 degrees C...
  93. ncbi Effects of atrazine on embryos, larvae, and adults of anuran amphibians
    J W Allran
    Department of Wildlife Ecology, University of Wisconsin, Madison 53706, USA
    Environ Toxicol Chem 20:769-75. 2001
    ..Atrazine treatments did not affect hatchability of embryos or 96-h posthatch mortality of larvae of Rana pipiens, Rana sylvatica, or Bufo americanus. Furthermore, atrazine had no effect on swimming speed (measured for R...
  94. ncbi Amphibian decline. Ubiquitous herbicide emasculates frogs
    Jay Withgott
    Science 296:447-8. 2002
  95. ncbi Functional morphology of proximal hindlimb muscles in the frog Rana pipiens
    William J Kargo
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    J Exp Biol 205:1987-2004. 2002
    ..In the present study, we developed the initial musculotendon subsystem of a realistic model of the frog Rana pipiens. We measured the anatomical properties of 13 proximal muscles in the frog hindlimb and incorporated these ..
  96. pmc Local calcium release in mammalian skeletal muscle
    N Shirokova
    Department of Molecular Biophysics and Physiology, Rush University, 1750 W Harrison Street, Chicago, IL 60612, USA
    J Physiol 512:377-84. 1998
    ..The present results suggest that in these rat fibres there is little contribution by CICR to Ca2+ release triggered by depolarization, and a lack of concerted channel opening...
  97. ncbi Inhibitory action of the gonadopeptide inhibin on amphibian (Rana pipiens) steroidogenesis and oocyte maturation
    Y W Lin
    Biology Department, School of Natural and Health Sciences, Barry University, Miami Shores, Florida 33161, USA
    J Exp Zool 284:232-40. 1999
    ..we have examined the effects of the gonadopeptide inhibin in the process of oocyte maturation using amphibian (Rana pipiens) fully grown preovulatory ovarian follicles cultured in vitro...
  98. pmc Cytostatic and cytotoxic properties of Amphinase: a novel cytotoxic ribonuclease from Rana pipiens oocytes
    Barbara Ardelt
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, New York 10595, USA
    Cell Cycle 6:3097-102. 2007
    ..It was recently reported that Rana pipiens oocytes contain still another ribonuclease, named Amphinase (Amph)...
  99. ncbi Localization of the two constitutively expressed nitric oxide synthase isoforms (nNOS and eNOS) in the same cell types in the saccule maculae of the frog Rana pipiens by immunoelectron microscopy: evidence for a back-up system?
    Ulf Rüdiger Heinrich
    ENT Department, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, D 55131 Mainz, Germany
    J Electron Microsc (Tokyo) 52:197-206. 2003
    ..cellular and subcellular levels, ultrathin sections of London Resin White-embedded saccule maculae of the frog Rana pipiens were incubated with various concentrations of commercially available antibodies to nNOS and eNOS...
  100. ncbi Opposite effects of cooling on twitch contractions of skeletal muscle isolated from tropical toads (Leptodactylidae) and northern frogs (Ranidae)
    C Caputo
    IVIC, , Caracas, Venezuela
    J Comp Physiol B 168:600-10. 1998
    Cooling increases the twitch force of frog skeletal muscle (Rana temporaria; Rana pipiens), but decreases the twitch force of tropical toad muscle (Leptodactylus insularis)...
  101. ncbi Synchronization modulation of Na/K pump molecules can hyperpolarize the membrane resting potential in intact fibers
    Wei Chen
    Cellular and Molecular Biophysics, University of South Florida, Tampa, FL 33620, USA
    J Bioenerg Biomembr 39:117-26. 2007
    ..The results clearly show that the entrainment of the pump molecules by the synchronization modulation electric field can effectively increase the ionic concentration gradient, and hence, hyperpolarize the membrane potential...

Research Grants39

  1. STRUCTURE/FUNCTION OF MYOSIN IN SKELETAL MUSCLE
    Gordon Lutz; Fiscal Year: 2001
    ..Single muscle fibers will be isolated from adult Rana pipiens and the force-velocity properties will be measured within 1 mm segments along the full length of the fiber...
  2. DIVERSITY IN MEMBRANE PROPERTIES OF INNER EAR HAIR CELLS
    ELBA SERRANO; Fiscal Year: 1993
    ..This research will use the inner ear from the anuran species, Rana pipiens, for comparative cellular studies of vestibular and auditory hair cells...
  3. BACTERIAL EXPRESSION OF LYMPHOMA RNRNASE IMMUNOTOXIN
    SHUI ON LEUNG; Fiscal Year: 1999
    ..this project is to employ a bacterial high-level expression system to express recombinant ribonuclease of frog (Rana Pipiens) origin (rpRNase), either alone, or as a fusion protein with a humanized single chain antibody specific for B-..
  4. The role of forelimb muscles in frog jumping
    Richard Essner; Fiscal Year: 2005
    ..goal is to incorporate data from these elements into an existing realistic musculoskeletal model of the frog (Rana pipiens)...
  5. DESIGN OF MUSCULAR SYSTEMS
    LAWRENCE ROME; Fiscal Year: 2003
    ..g., crossbridge kinetics) to whole animal function in meaningful way. The frog, Rana pipiens, presents a superb model to proceed to this level...
  6. Dual Confocal Microscopic Scanner
    Eduardo Rios; Fiscal Year: 2008
    ..The extraordinary level of institutional support bestowed on this proposal attests to its perceived importance for basic and translational research at Rush University. [unreadable] [unreadable] [unreadable]..
  7. ELECTRICAL INJURY-- ELECTROCONFORMATION OF MEM PROTEINS
    Wei Chen; Fiscal Year: 2004
    ..These studies will lead to a comprehensive understanding of the underlying mechanisms involved in electrical injury. ..
  8. EXCITATION-CONTRACTION COUPLING IN STRIATED MUSCLE
    STEPHEN BAYLOR; Fiscal Year: 2005
    ..Overall, the knowledge obtained will contribute importantly to understanding the mechanisms of intracellular Ca signaling and the mechanisms by which specific drugs and diseases affect muscle performance. ..
  9. FGF Regulation of GnRH Neurons
    Pei San Tsai; Fiscal Year: 2008
    ..In addition, it will reveal if mutations on other genes encoding FGFs/FGFRs are also candidates for these human disorders. ..
  10. FUNCTIONAL EVOLUTION OF OPIOID RECEPTORS
    Craig Stevens; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  11. MECHANISMS OF SKELETAL MUSCLE FATIGUE
    Jay Williams; Fiscal Year: 2001
    ..In addition, it will attempt to identify direct links between muscle glycogen levels, CHO metabolism and the fatigue process. ..
  12. OLFACTORY ELECTROPHYSIOLOGY IN CAENORHABDITIS ELEGANS
    STEVEN KLEENE; Fiscal Year: 2003
    ..The work proposed here will advance understanding of the molecular and cellular processes which subserve sensory function. ..
  13. High-Speed, Depth-Resolved Images of Cardiac physiology
    Guy Salama; Fiscal Year: 2007
    ..We focus here on the heart because therein lie salient problems that are ready to be addressed by this new technology. However, the wide range of possible applications may lead to the commercialization of this new technology. ..
  14. From infra- to ultrasound: Diversity in acoustic processing by the vertebrate ear
    Peter M Narins; Fiscal Year: 2010
    ..Ultimately, our research may lead to new therapeutic approaches to treatment of hyperacusis and noise-induced tinnitus, two known syndromes in which efferent system malfunction has been implicated. ..
  15. Investigation of Human Muscle Function in vivo
    BRUCE DAMON; Fiscal Year: 2005
    ..In this application we have requested partial support for the trainees to attend and benefit from the workshop; we have also requested support for a minority trainee travel stipend program...
  16. CONTROL OF CALCIUM RELEASE IN SKELETAL MUSCLE FIBERS
    Martin Schneider; Fiscal Year: 2006
    ..The results of these studies should provide further insight into muscle pathological states and to the overall wellness associated with functioning muscle. ..
  17. MRI Detection of Skeletal Muscle Microvascular Dysfunction
    BRUCE DAMON; Fiscal Year: 2007
    ..In these studies we will be developing new methods for studying blood flow to muscles non-invasively. [unreadable] [unreadable] [unreadable]..
  18. ACOUSTIC COMMUNICATION AND HORMONE CONTROL
    Walter Wilczynski; Fiscal Year: 2006
    ..These are all natural behaviors with clinical significance, as dysfunctions of sexual response and reproductive function, affiliation and aggression, and stress are important human clinical problems. ..
  19. STEM CELLS AND PERIODONTAL BIOENGINEERING
    THOMAS DIEKWISCH; Fiscal Year: 2007
    ..3. To test the conditions necessary to differentiate stem cells into periodontal cells in vitro. 4. To ask the question whether stem cells will mimic existing periodontal tissues following tissue implantation. ..
  20. Activity Dependent Signaling in Muscle Fiber Plasticity
    Martin Schneider; Fiscal Year: 2007
    ..The studies proposed here should have important bearing on the effects of use and disuse on muscle fiber gene expression. [unreadable] [unreadable]..
  21. BIOLOGY AND BIOMETRICS OF ENAMEL CRYSTAL GROWTH
    THOMAS DIEKWISCH; Fiscal Year: 2005
    ....
  22. Peptide Hormone Structure Function
    Victor J Hruby; Fiscal Year: 2010
    ....
  23. MECHANISMS OF REPOLARIZATION-INDUCED ARRHYTHMIAS
    Guy Salama; Fiscal Year: 2002
    ..abstract_text> ..
  24. Conference on Muscle: Excitation-Contraction Coupling
    Martin Schneider; Fiscal Year: 2003
    ..The organizing committee and session leaders will strive to achieve appropriate representation of women, minorities and disabled. All facilities are handicapped accessible. ..
  25. BASAL LAMINA MOLECULES AND SYNAPTOGENESIS
    MICHAEL WERLE; Fiscal Year: 2003
    ....
  26. CP 27 GENE FUNCTION IN TOOTH DEVELOPMENT
    THOMAS DIEKWISCH; Fiscal Year: 2004
    ..Understanding the function of CP27 may provide the basis for the development of novel clinical aids for craniofacial diseases. ..
  27. ROS Defense Mechanisms in Brain Reoxygenation
    Sarah Milton; Fiscal Year: 2004
    ....
  28. NMDA Receptors and Ethanol Withdrawal Seizures
    Adam Hendricson; Fiscal Year: 2005
    ....
  29. Local Ca2+ signaling in sympathetic ganglion neurons
    Martin Schneider; Fiscal Year: 2005
    ..Our results will provide new insights regarding local Ca2+ signaling mechanisms that could be compromised in neuronal disease. ..
  30. Gender-Differences in Cardiac Repolarization/Arrhythmias
    Guy Salama; Fiscal Year: 2005
    ..abstract_text> ..
  31. Chronic Cannabinoids, Tumor Growth and Hyperalgesia
    DARRYL HAMAMOTO; Fiscal Year: 2005
    ..Positive results from these studies would suggest that cannabinoids could be useful for the treatment of cancer pain. ..
  32. BUILDING A TOOTH: The Chicago Blueprint for Dental Regeneration
    THOMAS DIEKWISCH; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  33. Factors that Initiate Arrhythamias in Long QT Syndrome
    Guy Salama; Fiscal Year: 2006
    ..Stimulation paradigms that i) enhance DOR or ii) elicit a bradycardia followed by a tachycardia are more likely to increase the incidence of EADs or TdP. ..
  34. Chronic Ingestion of Lutein and Zeaxanthin in Primates
    Frederick Khachik; Fiscal Year: 2003
    ..Lutein/zeaxanthin supplements have widely used as a nutritional supplement un the U.S. since 1995, while safety and efficacy of these carotenoids has not yet been established. ..
  35. EXOCYTOSIS & MEMBRANE TRAFFICKING IN NEUROENDOCRINE CELL
    Joseph Angleson; Fiscal Year: 2003
    ..abstract_text> ..
  36. Quantifying Oxidative Metabolism in Diabetic Muscle
    BRUCE DAMON; Fiscal Year: 2005
    ..Moreover, these techniques will be suitable for future studies of the effects of exercise training or other interventions in diabetic animal models. ..