Genomes and Genes
Summary: Animals having a vertebral column, members of the phylum Chordata, subphylum Craniata comprising mammals, birds, reptiles, amphibians, and fishes.
Publications266 found, 100 shown here
- The origins of genome complexityMichael Lynch
Department of Biology, Indiana University, Bloomington, IN 47405, USA
Science 302:1401-4. 2003..The enormous long-term effective population sizes of prokaryotes may impose a substantial barrier to the evolution of complex genomes and morphologies...
- EnsemblCompara GeneTrees: Complete, duplication-aware phylogenetic trees in vertebratesAlbert J Vilella
EMBL EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
Genome Res 19:327-35. 2009..All data are made available in a number of formats and will be kept up to date with the Ensembl project...
- Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomesAdam Siepel
Center for Biomolecular Science and Engineering, University of California, Santa Cruz, Santa Cruz, California 95064, USA
Genome Res 15:1034-50. 2005..From yeasts to vertebrates, in order of increasing genome size and general biological complexity, increasing fractions of conserved bases ..
- The impact of conservation on the status of the world's vertebratesMichael Hoffmann
IUCN SSC Species Survival Commission, c o United Nations Environment Programme World Conservation Monitoring Centre, 219 Huntingdon Road, Cambridge CB3 0DL, UK
Science 330:1503-9. 2010..International Union for Conservation of Nature Red List, we present an assessment of the status of the world's vertebrates. One-fifth of species are classified as Threatened, and we show that this figure is increasing: On average, 52 ..
- NeuN, a neuronal specific nuclear protein in vertebratesR J Mullen
Department of Anatomy, University of Utah School of Medicine, Salt Lake City 84132
Development 116:201-11. 1992..This mAb and the protein recognized by it serve as an excellent marker for neurons in the central and peripheral nervous systems in both the embryo and adult, and the protein may be important in the determination of neuronal phenotype...
- Physiology of cell volume regulation in vertebratesElse K Hoffmann
Department of Biology, University of Copenhagen, Copenhagen, Denmark
Physiol Rev 89:193-277. 2009..A discussion of this issue concludes the review...
- Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebratesLajos Mátés
Max Delbruck Center for Molecular Medicine, Berlin, Germany
Nat Genet 41:753-61. 2009The Sleeping Beauty (SB) transposon is a promising technology platform for gene transfer in vertebrates; however, its efficiency of gene insertion can be a bottleneck in primary cell types...
- The amphioxus genome and the evolution of the chordate karyotypeNicholas H Putnam
Department of Energy Joint Genome Institute, Walnut Creek, California 94598, USA
Nature 453:1064-71. 2008..comparisons illuminate the murky relationships among the three chordate groups (tunicates, lancelets and vertebrates), and allow not only reconstruction of the gene complement of the last common chordate ancestor but also ..
- Toward automatic reconstruction of a highly resolved tree of lifeFrancesca D Ciccarelli
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
Science 311:1283-7. 2006..For example, we place the phylum Acidobacteria as a sister group of delta-Proteobacteria, support a Gram-positive origin of Bacteria, and suggest a thermophilic last universal common ancestor...
- Catalog of microRNA seed polymorphisms in vertebratesMinja Zorc
Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Domzale, Slovenia
PLoS ONE 7:e30737. 2012..In the present study, we developed an online tool for the detection of miRNA polymorphisms (miRNA SNiPer) in vertebrates (http://www.integratomics-time...
- Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotypeOlivier Jaillon
UMR 8030 Genoscope, CNRS and Université d Evry, 2 rue Gaston Cremieux, 91057 Evry Cedex, France
Nature 431:946-57. 2004..Comparison with other vertebrates and a urochordate indicates that fish proteins have diverged markedly faster than their mammalian homologues...
- Nine exceptional radiations plus high turnover explain species diversity in jawed vertebratesMichael E Alfaro
Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 106:13410-4. 2009..a diversity tree summarizing both evolutionary relationships and species richness of 44 major clades of jawed vertebrates. We identify 9 major changes in the tempo of gnathostome diversification; the most significant of these lies at ..
- Genetics, development and evolution of adaptive pigmentation in vertebratesH E Hoekstra
Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093 0116, USA
Heredity (Edinb) 97:222-34. 2006..served as the focus of many classic studies of naturally occurring phenotypic variation in a wide variety of vertebrates, providing some of the most compelling cases for parallel and convergent evolution...
- Polycomb group response elements in Drosophila and vertebratesJudith A Kassis
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Adv Genet 81:83-118. 2013..In this review, we discuss evidence for PREs in vertebrates and explore similarities and differences between Drosophila and vertebrate PREs.
- Timing of genome duplications relative to the origin of the vertebrates: did cyclostomes diverge before or after?Shigehiro Kuraku
Laboratory for Evolutionary Morphology, RIKEN Center for Developmental Biology, Kobe, Japan
Mol Biol Evol 26:47-59. 2009..duplications are thought to have played an important role in the establishment of gene repertoires in vertebrates. These events occurred during chordate evolution after the split of the urochordate and cephalochordate ..
- Natural selection at major histocompatibility complex loci of vertebratesA L Hughes
Department of Biology, Pennsylvania State University, University Park 16802, USA
Annu Rev Genet 32:415-35. 1998..d) Introns have been homogenized relative to exons over evolutionary time, suggesting that balancing selection acts to maintain diversity in the latter, in contrast to the former...
- Two rounds of whole genome duplication in the ancestral vertebrateParamvir Dehal
Evolutionary Genomics Department, Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Walnut Creek, California, USA
PLoS Biol 3:e314. 2005..Our results highlight the potential for these large-scale genomic events to have driven the evolutionary success of the vertebrate lineage...
- Vertebrate genome evolution and the zebrafish gene mapJ H Postlethwait
Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
Nat Genet 18:345-9. 1998..Vertebrate ancestors probably had single copies of genes now found in multiple copies in vertebrates and gene maps suggest that this occurred by polyploidization...
- Evolutionary transitions in parental care and live bearing in vertebratesJohn D Reynolds
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
Philos Trans R Soc Lond B Biol Sci 357:269-81. 2002We provide the first review of phylogenetic transitions in parental care and live bearing for a wide variety of vertebrates. This includes new analyses of both numbers of transitions and transition probabilities...
- Coagulation systems of invertebrates and vertebrates and their roles in innate immunity: the same side of two coins?Torsten G Loof
Department of Clinical Sciences, Lund University, Lund, Sweden
J Innate Immun 3:34-40. 2011..More recent evidence suggests that vertebrates, too, rely on clotting as an immune effector mechanism...
- Olfactory signalling in vertebrates and insects: differences and commonalitiesU Benjamin Kaupp
Center of Advanced European Studies and Research, Ludwig Erhard Allee 2, Bonn, Germany
Nat Rev Neurosci 11:188-200. 2010b>Vertebrates and insects have evolved complex repertoires of chemosensory receptors to detect and distinguish odours...
- Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional networkEric Dessaud
Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
Development 135:2489-503. 2008..We discuss recent advances in our understanding of these events and highlight unresolved questions...
- Highly conserved elements discovered in vertebrates are present in non-syntenic loci of tunicates, act as enhancers and can be transcribed during developmentRemo Sanges
Laboratory of Animal Physiology and Evolution, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
Nucleic Acids Res 41:3600-18. 2013..are conserved in non-syntenic regions between vertebrate and tunicate genomes, while being syntenic among vertebrates. Nevertheless, in all the groups, they are significantly associated with transcription factors showing specific ..
- Structural and functional evolution of gonadotropin-releasing hormone in vertebratesK Okubo
Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki, Aichi, Japan
Acta Physiol (Oxf) 193:3-15. 2008..This review describes an overview of what is currently known about GnRH in vertebrates in the context of its structural and functional evolution...
- Fossils, genes and the evolution of animal limbsN Shubin
Department of Biology, University of Pennsylvania, Philadelphia 19104, USA
Nature 388:639-48. 1997..Although their respective evolutionary histories are unique, vertebrate, insect and other animal appendages are organized by a similar genetic regulatory system that may have been established in a common ancestor...
- Reconstruction of the vertebrate ancestral genome reveals dynamic genome reorganization in early vertebratesYoichiro Nakatani
Department of Computational Biology, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa 277 0882, Japan
Genome Res 17:1254-65. 2007Although several vertebrate genomes have been sequenced, little is known about the genome evolution of early vertebrates and how large-scale genomic changes such as the two rounds of whole-genome duplications (2R WGD) affected ..
- Early evolution of conserved regulatory sequences associated with development in vertebratesGayle K McEwen
School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom
PLoS Genet 5:e1000762. 2009..Although markedly shorter and less well conserved than within jawed vertebrates, identified lamprey CNEs are able to drive specific patterns of expression in zebrafish embryos, which are ..
- Tuning in to the signals: noncoding sequence conservation in vertebrate genomesGreg Elgar
School of Biological and Chemical Sciences, Queen Mary, University of London, London, UK
Trends Genet 24:344-52. 2008..In vertebrates, the comparison of human and rodent genomes and the comparison of evolutionarily distant genomes, such as human ..
- Vascular regeneration and angiogenic-like sprouting mechanism in a compound ascidian is similar to vertebratesFabio Gasparini
Dipartimento di Biologia, Universita di Padova, Via U Bassi 58 B 35131, Padova, Italy
Evol Dev 10:591-605. 2008..such as embryogenesis, asexual reproduction, and regeneration, because they are the closest relatives to vertebrates and are the only chordates to reproduce both sexually and asexually...
- Phylogenic outline of the olfactory system in vertebratesKazumi Taniguchi
School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Japan
J Vet Med Sci 73:139-47. 2011..The subdivision of the olfactory system into the main and the vomeronasal olfactory systems may partly be induced by the difference between paraphyletic groups and monophyletic groups in the phylogeny of vertebrates.
- microRNAs reveal the interrelationships of hagfish, lampreys, and gnathostomes and the nature of the ancestral vertebrateAlysha M Heimberg
Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
Proc Natl Acad Sci U S A 107:19379-83. 2010Hagfish and lampreys are the only living representatives of the jawless vertebrates (agnathans), and compared with jawed vertebrates (gnathostomes), they provide insight into the embryology, genomics, and body plan of the ancestral ..
- Global distribution and conservation of rare and threatened vertebratesRichard Grenyer
Department of Biology, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22904, USA
Nature 444:93-6. 2006..Instead, priority areas for biodiversity conservation must be based on high-resolution data from multiple taxa...
- Tissue/planar cell polarity in vertebrates: new insights and new questionsYanshu Wang
Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Development 134:647-58. 2007..review focuses on the tissue/planar cell polarity (PCP) pathway and its role in generating spatial patterns in vertebrates. Current evidence suggests that PCP integrates both global and local signals to orient diverse structures with ..
- Adult neurogenesis in non-mammalian vertebratesPrisca Chapouton
Department Zebrafish Neurogenetics, GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Neuherberg, Germany
Bioessays 29:745-57. 2007..Current research mainly focuses on rodents, but we review here recent examination of non-mammalian vertebrates, which demonstrates that bona fide adult neural stem cells exist in these species...
- Mid-Mesozoic flea-like ectoparasites of feathered or haired vertebratesTai Ping Gao
College of Life Sciences, Capital Normal University, Beijing 100048, China
Curr Biol 22:732-5. 2012....
- Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebratesJin Ben
Developmental and Biomedical Genetics Group, Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
Development 138:4969-78. 2011..Our findings underline the importance of the primary cilium for Hh signaling in zebrafish and reveal the conservation of Ta3 function during vertebrate evolution...
- Distribution of central pattern generators for rhythmic motor outputs in the spinal cord of limbed vertebratesO Kiehn
Department of Medical Physiology, University of Copenhagen, Denmark
Ann N Y Acad Sci 860:110-29. 1998..In this paper we concentrate on spinal CPGs in limbed vertebrates and in particular address the question: Where in the spinal cord, in the longitudinal and transverse planes, ..
- Translational selection frequently overcomes genetic drift in shaping synonymous codon usage patterns in vertebratesAoife Doherty
Bioinformatics and Molecular Evolution Unit, Department of Biology, National University of Ireland Maynooth, Maynooth, Co Kildare, Ireland
Mol Biol Evol 30:2263-7. 2013..To date, detection of translational selection in vertebrates has proven to be a challenging task, obscured by small long-term effective population sizes in larger animals ..
- Worlds within worlds: evolution of the vertebrate gut microbiotaRuth E Ley
Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri 63108, USA
Nat Rev Microbiol 6:776-88. 2008....
- Transposon-mediated genome manipulation in vertebratesZoltan Ivics
Max Delbruck Center for Molecular Medicine, Berlin, Germany
Nat Methods 6:415-22. 2009..Here we provide an overview of transposon-based methods used in vertebrate model organisms with an emphasis on the mouse system and highlight the most important considerations concerning genetic applications of the transposon systems...
- Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebratesDanwei Huangfu
Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
Development 133:3-14. 2006..is evolutionarily conserved, recent studies indicate that fundamental differences exist between Drosophila and vertebrates in the way signals are transduced from the membrane protein Smoothened (Smo) to the Ci/Gli transcription ..
- Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebratesMichael Dean
Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702, USA
Annu Rev Genomics Hum Genet 6:123-42. 2005..Most ABC transporters are conserved in all vertebrates, but there are also several examples of recent duplication and gene loss...
- Skeletal muscle formation in vertebratesM Buckingham
Unité de Génétique Moléculaire du Développement, CNRS URA1947, Departement de Biologie Moleculaire, Institut Pasteur, 25 rue du Dr Roux, 75724 Cedex 15, Paris, France
Curr Opin Genet Dev 11:440-8. 2001..The myogenic identity of precursor cells in the adult depends on Pax7, the orthologue of Pax3 which is required for early myogenesis; this finding is of major importance for muscle regeneration and the active field of stem cell research...
- Analysis of the vertebrate insulator protein CTCF-binding sites in the human genomeTae Hoon Kim
Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093 0653, USA
Cell 128:1231-45. 2007..In vertebrates, insulator's function requires association with the CCCTC-binding factor (CTCF), a protein that recognizes long ..
- The draft genome of Ciona intestinalis: insights into chordate and vertebrate originsParamvir Dehal
U S Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
Science 298:2157-67. 2002..To illuminate the origins of chordate and vertebrates, we generated a draft of the protein-coding portion of the genome of the most studied ascidian, Ciona ..
- Breeding together: kin selection and mutualism in cooperative vertebratesTim Clutton-Brock
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Science 296:69-72. 2002In cooperatively breeding vertebrates, nonbreeding helpers raise young produced by dominant breeders...
- Phylogenetic performance of mitochondrial protein-coding genes in resolving relationships among vertebratesR Zardoya
Department of Ecology and Evolution, State University of New York at Stony Brook 11794 5245, USA
Mol Biol Evol 13:933-42. 1996....
- The evolution of isochore patterns in vertebrate genomesMaria Costantini
Stazione Zoologica Anton Dohrn, Naples, Italy
BMC Genomics 10:146. 2009..g., between amphibians and mammals); and (v) isochores are tightly linked to a number of basic biological properties, such as gene density, gene expression, replication timing and recombination...
- DNA methylation and structural and functional bimodality of vertebrate promotersNavin Elango
School of Biology, Georgia Institute of Technology, USA
Mol Biol Evol 25:1602-8. 2008....
- Codon-substitution models for heterogeneous selection pressure at amino acid sitesZ Yang
Department of Biology, University College London, London NW1 2HE, United Kingdom
Genetics 155:431-49. 2000..Genes undergoing positive selection include the beta-globin gene from vertebrates, mitochondrial protein-coding genes from hominoids, the hemagglutinin (HA) gene from human influenza virus A, ..
- CpG islands in vertebrate genomesM Gardiner-Garden
Kanematsu Laboratories, Royal Prince Alfred Hospital, Camperdown N S W, Australia
J Mol Biol 196:261-82. 1987..Possible functions of CpG islands in transcriptional and post-transcriptional regulation of gene expression were discussed, and were related to theories for the maintenance of CpG islands as "methylation-free zones" in germline DNA...
- Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebratesTatsuo Miyamoto
Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734 8553, Japan
Hum Mol Genet 20:2058-70. 2011....
- Links between global taxonomic diversity, ecological diversity and the expansion of vertebrates on landSarda Sahney
Department of Earth Sciences, University of Bristol, Bristol, UK
Biol Lett 6:544-7. 2010Tetrapod biodiversity today is great; over the past 400 Myr since vertebrates moved onto land, global tetrapod diversity has risen exponentially, punctuated by losses during major extinctions...
- Motor primitives in vertebrates and invertebratesTamar Flash
Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
Curr Opin Neurobiol 15:660-6. 2005In recent years different lines of evidence have led to the idea that motor actions and movements in both vertebrates and invertebrates are composed of elementary building blocks...
- Tunicates and not cephalochordates are the closest living relatives of vertebratesFrédéric Delsuc
Departement de Biochimie, Centre Robert Cedergren, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec H3C3J7, Canada
Nature 439:965-8. 2006Tunicates or urochordates (appendicularians, salps and sea squirts), cephalochordates (lancelets) and vertebrates (including lamprey and hagfish) constitute the three extant groups of chordate animals...
- Early eye development in vertebratesR L Chow
Program in Developmental Biology, The Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
Annu Rev Cell Dev Biol 17:255-96. 2001..Questions about early eye development first addressed using tissue manipulations remain topical as we try to understand the molecular basis of this process...
- Hedgehog secretion and signal transduction in vertebratesKaitlyn E Ryan
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
J Biol Chem 287:17905-13. 2012..Although many aspects of the Drosophila Hh pathway are conserved in vertebrates, mechanistic differences between the two species have begun to emerge...
- Duplications of hox gene clusters and the emergence of vertebratesNatalia Soshnikova
Department of Genetics and Evolution, University of Geneva, Sciences III, Quai Ernest Ansermet 30, 1211 Geneva 4, Switzerland
Dev Biol 378:194-9. 2013..suggesting that the ancestral HoxA/B cluster was co-opted to help in diversifying the complex organ in vertebrates. Other phenotypic effects observed seem to illustrate the resurgence of ancestral (plesiomorphic) features...
- Sex chromosome evolution in non-mammalian vertebratesManfred Schartl
Physiologische Chemie I, Biozentrum der Universität Würzburg, Am Hubland, 97074 Wurzburg, Germany
Curr Opin Genet Dev 14:634-41. 2004..that function downstream of the mammalian master sex-determining gene, Sry, have been found in non-mammalian vertebrates. Although the components of the machinery that determines sex seem to be conserved, their interaction and most ..
- Impact of gene gains, losses and duplication modes on the origin and diversification of vertebratesCristian Canestro
Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Av Diagonal 645, 08028 Barcelona, Spain
Semin Cell Dev Biol 24:83-94. 2013The study of the evolutionary origin of vertebrates has been linked to the study of genome duplications since Susumo Ohno suggested that the successful diversification of vertebrate innovations was facilitated by two rounds of whole-..
- Transposable elements as drivers of genomic and biological diversity in vertebratesAstrid Böhne
Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, France
Chromosome Res 16:203-15. 2008..Taken together, these observations indicate that transposable elements are major drivers of genomic and biological diversity in vertebrates, with possible important roles in speciation and major evolutionary transitions.
- Molecular evolution of multiple forms of kisspeptins and GPR54 receptors in vertebratesYeo Reum Lee
Laboratory of G Protein Coupled Receptors, Graduate School of Medicine, Korea University, Seoul, Korea
Endocrinology 150:2837-46. 2009..These data shed new light on the molecular evolution of the kisspeptin-GPR54 system in vertebrates.
- MicroRNAs and the advent of vertebrate morphological complexityAlysha M Heimberg
Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA
Proc Natl Acad Sci U S A 105:2946-50. 2008..vertebrate complexity has been sought in genome duplication events (GDEs) that occurred during the emergence of vertebrates, but evidence beyond coincidence is wanting...
- The genetic and evolutionary basis of colour variation in vertebratesMichael Hofreiter
Department of Biology, University of York, York, UK
Cell Mol Life Sci 67:2591-603. 2010Variation in pigmentation is one of the most conspicuous phenotypic traits in vertebrates. Although mammals show less variation in body pigmentation than other vertebrate groups, the genetics of colour determination and variation is best ..
- Extending the aerolysin family: from bacteria to vertebratesPawel Szczesny
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
PLoS ONE 6:e20349. 2011..Its putative role in the virulence of B. anthracis and its three dimensional model are discussed...
- Skin regeneration in adult axolotls: a blueprint for scar-free healing in vertebratesAshley W Seifert
Department of Biology, University of Florida, Gainesville, Florida, United States of America
PLoS ONE 7:e32875. 2012..Our findings outline a blueprint to understand the cellular and molecular mechanisms coordinating scar-free healing that will be useful towards elucidating new regenerative therapies targeting fibrosis and wound repair...
- Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammalsAlicia Felip
Consejo Superior de Investigaciones Cientificas, Instituto de Acuicultura de Torre de la Sal, Ribera de Cabanes, 12595 Castellon, Spain
Mol Cell Endocrinol 312:61-71. 2009..are the first to provide conclusive evidence for the existence of a second KiSS gene, KiSS-2, in non-placental vertebrates, whose product is likely to play a dominant stimulatory role in the regulation of the gonadotropic axis at ..
- Homolonto: generating homology relationships by pairwise alignment of ontologies and application to vertebrate anatomyGilles Parmentier
Department of Ecology and Evolution, University of Lausanne, 1015 Lausanne, Switzerland
Bioinformatics 26:1766-71. 2010..To compare such data between species, we need to establish relations between ontologies describing different species...
- Evolution of colour vision in vertebratesJ K Bowmaker
Department of Visual Science, University College London, UK
Eye (Lond) 12:541-7. 1998....
- OrthoDB: the hierarchical catalog of eukaryotic orthologsEvgenia V Kriventseva
Department of Genetic Medicine and Development, University of Geneva Medical School, Swiss Institute of Bioinformatics, 1 rue Michel Servet, Geneva, Switzerland
Nucleic Acids Res 36:D271-5. 2008..the basis of all-against-all Smith-Waterman sequence comparisons to analyze 58 eukaryotic genomes, focusing on vertebrates, insects and fungi to facilitate further comparative studies. The database is freely available at http://cegg...
- Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebratesB M Lange
Cell Biology and Cell Biophysics Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
EMBO J 19:1252-62. 2000..is localized at the centrosome throughout the cell cycle at different stages of development in Drosophila and vertebrates. This association between Hsp90 and the centrosome can be observed in purified centrosomes and after treatment ..
- MHC studies in nonmodel vertebrates: what have we learned about natural selection in 15 years?L Bernatchez
Department de Biologie, Universite Laval, Ste Foy, Quebec, Canada
J Evol Biol 16:363-77. 2003..that positive selection has a determinant role in shaping patterns of nucleotide diversity in MHC genes in all vertebrates studied...
- Stripes and belly-spots -- a review of pigment cell morphogenesis in vertebratesRobert N Kelsh
Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
Semin Cell Dev Biol 20:90-104. 2009..current understanding of mechanisms underlying the control of pigment cell migration and patterning in diverse vertebrates. The model systems discussed here - chick, mouse, and zebrafish - each provide unique insights into the major ..
- Vertebrate innovationsS M Shimeld
School of Animal and Microbial Sciences, University of Reading, Whiteknights, Reading RG6 6AJ, United Kingdom
Proc Natl Acad Sci U S A 97:4449-52. 2000..Comparative molecular and developmental data give new insights into the evolutionary origins of these characteristics and the complexity of the vertebrate body...
- The amphioxus genome illuminates vertebrate origins and cephalochordate biologyLinda Z Holland
Marine Biology Research Division, Scripps Institution of Oceanography, La Jolla, California 92093 0202, USA
Genome Res 18:1100-11. 2008Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago...
- Gen(om)e duplications in the evolution of early vertebratesA Sidow
Whitehead Institute, Cambridge, Massachusetts 02142, USA
Curr Opin Genet Dev 6:715-22. 1996..indicate that two large-scale gene duplications, most likely genome duplications, occurred in ancestors of vertebrates. Relaxed constraints allowed duplicated and thus redundant genes to diverge in a two stage mechanism...
- A common fold mediates vertebrate defense and bacterial attackCarlos J Rosado
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
Science 317:1548-51. 2007..In vertebrates, the ninth component of complement and perforin form oligomeric pores that lyse bacteria and kill virus-..
- Maternal transfer of antibodies in vertebrates: trans-generational effects on offspring immunityDennis Hasselquist
Department of Animal Ecology, Lund University, Ecology Building, 223 62 Lund, Sweden
Philos Trans R Soc Lond B Biol Sci 364:51-60. 2009..In vertebrates, maternal antibodies (matAb) are transferred from the mother, via the placenta, egg yolk or milk during ..
- Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspectiveTakashi Angata
Glycobiology Research and Training Center, Department of Medicine, University of California San Diego, La Jolla, California 92093 0687, USA
Chem Rev 102:439-69. 2002
- Early vertebrate whole genome duplications were predated by a period of intense genome rearrangementAndrew L Hufton
Max Planck Institute for Molecular Genetics, 12169 Berlin, Germany
Genome Res 18:1582-91. 2008..chordate genome, we have used gene proximity conservation to estimate rates of genome rearrangement throughout vertebrates and some of their invertebrate ancestors...
- Gene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolutionClaus Kemkemer
Institute of Human Genetics, University of Ulm, Ulm, Germany
BMC Evol Biol 9:84. 2009..Gene synteny analysis (E-painting) not only greatly reduces the complexity of comparative genome sequence analysis but also extends its evolutionary reach...
- Gonad morphogenesis in vertebrates: divergent means to a convergent endTony DeFalco
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Annu Rev Cell Dev Biol 25:457-82. 2009..We also discuss the plasticity of the adult gonad and consider how different genetic and environmental conditions can induce transitions between testis and ovary morphology...
- Structural and functional evolution of the basal ganglia in vertebratesA Reiner
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Memphis, 855 Monroe Avenue, Memphis, TN 38163
Brain Res Brain Res Rev 28:235-85. 1998....
- A multicassette Gateway vector set for high throughput and comparative analyses in ciona and vertebrate embryosAgnes Roure
Institut de Biologie du Developpement de Marseille Luminy, UMR 6216 CNRS Université de la Méditerranée, Marseille, France
PLoS ONE 2:e916. 2007..Large scale cross-species comparisons of protein function and cis-regulatory sequences may help to understand the emergence of specific traits during evolution...
- Dynamic limbic networks and social diversity in vertebrates: from neural context to neuromodulatory patterningJames L Goodson
Department of Biology, Indiana University, Bloomington, IN 47405, USA
Front Neuroendocrinol 30:429-41. 2009....
- What brought the adaptive immune system to vertebrates?--The jaw hypothesis and the seahorseT Matsunaga
Department of Immunology, University of Umea, Sweden
Immunol Rev 166:177-86. 1998A hypothesis is discussed that the adaptive immune system of vertebrates evolved in the gastrointestinal regions of primitive jawed fish (placoderms) due to increased localized injuries and infections which were inadvertently brought ..
- Asymmetry in the epithalamus of vertebratesM L Concha
Department of Anatomy and Developmental Biology, University College London, UK
J Anat 199:63-84. 2001..Structural asymmetries in this region are widespread amongst vertebrates and involve differences in size. neuronal organisation, neurochemistry and connectivity...
- Myogenic progenitor cells and skeletal myogenesis in vertebratesMargaret Buckingham
Department of Developmental Biology, CNRS URA2578, Pasteur Institute, 25 rue du Docteur Roux, 75015 Paris Cedex, France
Curr Opin Genet Dev 16:525-32. 2006..New approaches that permit the grafting of purified satellite cells demonstrate their capacity for efficient muscle repair and for self-renewal. Regeneration in amphibians is now also shown to involve Pax-positive progenitor cells...
- Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retentionAndrew L Hufton
Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
Genome Res 19:2036-51. 2009..This method is powerful enough to identify more than a thousand PCNEs that have been conserved between vertebrates and the basal chordate amphioxus...
- Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebratesSusannah Rankin
Systems Biology Department, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell 18:185-200. 2005..Based on sequence analysis, this protein has no apparent orthologs outside of the vertebrates. We speculate that the protein, which we have named sororin, regulates the ability of the cohesin complex to ..
- Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebratesDany S Adams
The Forsyth Center for Regenerative and Developmental Biology, and Department of Developmental Biology, Harvard School of Dental Medicine, 140 The Fenway, Boston, MA 02115, USA
Development 133:1657-71. 2006..Our data implicate H+-V-ATPase activity in patterning the LR axis of vertebrates and reveal mechanisms upstream and downstream of its activity...
- Neural bases of goal-directed locomotion in vertebrates--an overviewSten Grillner
The Nobel Institute for Neurophysiology, Department of Neuroscience, Karolinska Institutet, SE 17177 Stockholm, Sweden
Brain Res Rev 57:2-12. 2008....
- Connecting muscles to tendons: tendons and musculoskeletal development in flies and vertebratesRonen Schweitzer
Shriners Hospital for Children, Research Division, Portland, OR 97239, USA
Development 137:2807-17. 2010..systems is the anchoring of the force-generating muscles to the solid support of the organism: the skeleton in vertebrates and the exoskeleton in invertebrates...
- Revisiting the origin of the vertebrate Hox14 by including its relict sarcopterygian membersNathalie Feiner
Department of Biology, University of Konstanz, Konstanz, Germany
J Exp Zool B Mol Dev Evol 316:515-25. 2011..Particularly in vertebrates, their regulation is tightly coordinated by tandem arrays of genes [paralogy groups (PGs)] in four gene ..
- Evolution of the Rho family of ras-like GTPases in eukaryotesAnthony Boureux
Centre de Recherche en Biochimie des Macromolécules CNRS, IFR122, 34293 Montpellier, France
Mol Biol Evol 24:203-16. 2007..In vertebrates, gene duplications and retrotranspositions increased the size of each chordate Rho subfamily, whereas RhoH, the ..
- Using new tools to solve an old problem: the evolution of endothermy in vertebratesRoberto F Nespolo
Instituto de Ciencias de la Tierra y Evolución, Facultad de Ciencias, Universidad Austral de Chile
Trends Ecol Evol 26:414-23. 2011..Here, we argue that the evolution of endothermy could now be elucidated based on a joint, and perhaps unprecedented, effort of researchers from the fields of genomics, physiology and evolution...
- Differential loss and retention of cytoglobin, myoglobin, and globin-E during the radiation of vertebratesFederico G Hoffmann
School of Biological Sciences, University of Nebraska, Lincoln, USA
Genome Biol Evol 3:588-600. 2011..In contrast to the highly restricted phyletic distribution of GbE, the overwhelming majority of jawed vertebrates (gnathostomes) possess copies of the related cytoglobin (Cygb) and myoglobin (Mb) genes...
- The protein CTCF is required for the enhancer blocking activity of vertebrate insulatorsA C Bell
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0540, USA
Cell 98:387-96. 1999..site for CTCF, a previously identified eleven-zinc finger DNA-binding protein that is highly conserved in vertebrates. CTCF sites are present in all of the vertebrate enhancer-blocking elements we have examined...
- The evolution of adaptive immunity in vertebratesMasayuki Hirano
Emory Vaccine Center, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Adv Immunol 109:125-57. 2011Approximately 500 million years ago, two types of recombinatorial adaptive immune systems (AISs) arose in vertebrates. The jawed vertebrates diversify their repertoire of immunoglobulin domain-based T and B cell antigen receptors mainly ..
- Regulation of centrosome separation in yeast and vertebrates: common threadsHong Hwa Lim
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research A STAR, Proteos, 138673 Singapore
Trends Cell Biol 19:325-33. 2009..Here, we review recent studies that uncover new players and provide a greater understanding of the regulation of centrosome (or SPB) separation...
Research Grants115 found, 100 shown here
- GENETIC ANALYSIS OF POLARITYRUTH M STEWARD; Fiscal Year: 2010..originally identified in mammalian cells as an apoptosis-associated gene, but our results suggest that also in vertebrates it is associated with cell proliferation...
- Systematics of medically important Dermacentor tick vectorsDmitry A Apanaskevich; Fiscal Year: 2011..DESCRIPTION (provided by applicant): Ticks are obligate blood-feeders and temporary ectoparasites of terrestrial vertebrates. Among arthropods, ticks are second only to mosquitoes in transmitting pathogens to humans, pets, livestock, ..
- Mechanisms of Sex Determination in ZebrafishJOHN HARVEY POSTLETHWAIT; Fiscal Year: 2013..In nonmammalian vertebrates, other genes in the network determine sex, and in some species, environmental factors such as temperature or ..
- Integrated signaling of eicosanoids in HSC formation and regenerationTrista E North; Fiscal Year: 2013..In vertebrates, definitive hematopoietic stem cells (HSCs) produce each of the mature blood cell lineages of an individual ..
- Human middle-ear imaging, physiology, and biomechanicsCHARLES RICHARD STEELE; Fiscal Year: 2013..While it is well accepted that amongst terrestrial vertebrates, the mammalian middle ear is unique in its ability to transmit sounds from the external world to the cochlea ..
- Non-coding RNA engineers antibody diversityUttiya Basu; Fiscal Year: 2011..Antibodies are polypeptide complexes produced from B-lymphocytes that are present in the bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign antigens, such as bacteria and viruses...
- Intracellular Serpin Regulation of Intestinal Cell NecrosisGARY ARTHUR SILVERMAN; Fiscal Year: 2012..ancient, serpinIC anti-peptidase defense system regulates intestinal epithelial cell fitness in higher vertebrates. Conservation of this pathway provides the rationale for eventually developing novel anti- necrosis ..
- Dietary Supplement Creatine for Adolescent Females with SSRI-Resistant DepressionPERRY FRANKLIN RENSHAW; Fiscal Year: 2013..The organic acid creatine is endogenous to all vertebrates, and is known to play a vital role in maintaining ATP supplies in brain and skeletal muscle...
- IRON REGULATION OF GENE EXPRESSIONELIZABETH ANN LEIBOLD; Fiscal Year: 2013..All organisms have therefore developed mechanisms to sense, acquire and store iron. In vertebrates, iron metabolism is controlled by iron-regulatory protein 2 (IRP2)...
- Neuropeptide modulation of biogenic amine function and aggression in a crustaceanMaria A Sosa; Fiscal Year: 2013..evidence linking biogenic amines to behaviors associated with the establishment of social hierarchies in both vertebrates and invertebrates, but the specific mechanisms by which these amines act remain largely unknown...
- Role of Dendritic Ca2+ Transients in Respiratory Rhythm GenerationJack L Feldman; Fiscal Year: 2010..Breathing is a remarkable behavior in vertebrates that regulates gas exchange to support metabolism...
- Biological Functions of Iron Responsive ElementsRichard S Eisenstein; Fiscal Year: 2012..In vertebrates, iron regulatory protein 1 (IRP1) and IRP2 are central regulators of cellular iron metabolism...
- PROMOTER SPECIFICITY OF TRANSCRIPTION FACTORSDavid J Stillman; Fiscal Year: 2010..for studies of gene regulation, and since the transcription regulatory machinery is conserved between yeast and vertebrates the insights gained from studies in yeast are generally universal...
- Melanin-Concentrating Hormone: Ancestral Role in Feeding &Sleep RegulationPhilippe Mourrain; Fiscal Year: 2013..neurons and is up-regulated upon fasting, suggesting a conservation of MCH2/hMCH regulation and function across vertebrates. However, while mammalian hypothalamus harbors thousands of MCH cells, zebrafish larval and adult brains ..
- Developmental Regulation of Brain and BehaviorJULI S WADE; Fiscal Year: 2011DESCRIPTION (provided by applicant): Sex differences in brain and behavior exist across vertebrates. Several of these models have become powerful tools for elucidating mechanisms regulating development of neural structure and function, ..
- Genetic Control of Axial Patterning in Drosophila EyeAmit Singh; Fiscal Year: 2010..Since the genetic machinery is highly conserved it will be interesting to extrapolate the information to higher vertebrates. These studies will contribute towards understanding the genetic mechanism of early developmental events during ..
- Analysis of the tumor suppressor gene Tsc1 in motor neuron patterningOnanong Chivatakarn; Fiscal Year: 2013..In vertebrates, MNs develop in the ventral spinal cord and hindbrain, their cell bodies migrate to specific positions along ..
- Genomic approaches to inner ear hair cell regenerationMichael Lovett; Fiscal Year: 2010..Mammals cannot regenerate their hair cells. However, birds (and other lower vertebrates) can regenerate these cells...
- Presynaptic Mechanisms Regulating the Dopamine TransporterJAMES A HARDAWAY; Fiscal Year: 2013..genetic screen may reveal genes that both support DA signaling in the nematode and that are conserved in vertebrates, including humans...
- Development and Regulation of Cholinergic SynapsesAndres Villu Maricq; Fiscal Year: 2013..Because many of the gene products important for synaptic transmission are conserved from invertebrates to vertebrates, we predict that what we learn from our studies in C...
- The regulation and activation of STATs in adipocytesJacqueline M Stephens; Fiscal Year: 2013Adipocytes are highly specialized cells that play a major role in energy homeostasis in vertebrates. Obesity is the primary disease of fat cells and the most common metabolic disorder in the industrial world...
- Biological Functions of Iron Responsive ElementsRichard S Eisenstein; Fiscal Year: 2013..In vertebrates, iron regulatory protein 1 (IRP1) and IRP2 are central regulators of cellular iron metabolism...
- Role of exogenous melatonin in skin biologyAndrzej T Slominski; Fiscal Year: 2013DESCRIPTION (provided by applicant): It was assumed that in vertebrates melatonin is only produced in the pineal gland and retina...
- Targets of a cytidine deaminase required for left-right axis in XenopusAlin Vonica; Fiscal Year: 2010..The investigator found that APOBEC2, a cytidine deaminase conserved in vertebrates with no previously known function, is required for correct orientation of asymmetric internal organs (left-..
- NADPH-Oxidase and SLE SusceptibilitySwapan K Nath; Fiscal Year: 2013..5). Follow up bioinformatic and molecular modeling analyses on selected variants show high conservation across vertebrates, implicating potential functional roles and predicting detrimental effects on NADPHO assembly that ultimately ..
- Molecular Analysis of Juvenile Hormone ActionSubba R Palli; Fiscal Year: 2013..Since these hormones are not present in vertebrates, they represent attractive targets for the development of insect control methods...
- Identifying the Atoh1 targetome in hair cells with deep sequencingAndrew K Groves; Fiscal Year: 2013..Third, Atoh1 is one of the first genes to be expressed during hair cell regeneration in non-mammalian vertebrates. Finally, ectopic expression of Atoh1 is sufficient to generate new hair cells in some regions of the inner ear ..
- Mycobacterium tuberculosis carbon metabolism in vivoJohn D McKinney; Fiscal Year: 2010..cycle, which is required for metabolism of fatty acid substrates, is widespread among prokaryotes but absent in vertebrates. Previously we reported that isocitrate lyase 1 (ICL1) and 2 (ICL2), which catalyze the first unique reaction ..
- Biochemistry and Cell Biology of CHC22 ClathrinFrances M Brodsky; Fiscal Year: 2013..The gene encoding CHC22 is present in humans and other vertebrates but evolved into a pseudogene in mice, so humans, but not mice, express CHC22 clathrin...
- A search for genes that regulate allogeneic stem cell competitionIrving L Weissman; Fiscal Year: 2013DESCRIPTION (provided by applicant): Graft rejection in immune competent vertebrates can utilize both T and NK cell responses to hematopoietic cell transplants [HCT] and tissue grafts...
- Symbiotic Rickettsia Species as a Model System for the Study of Folate BiosynthesJianmin Zhong; Fiscal Year: 2012..The sole diet of most ticks is blood from vertebrates, but the sources of B-vitamins for Ixodes pacificus ticks are unknown...
- Role of Cofilin and Wnt Signaling in Neural Crest DevelopmentO apos NEIL WIGGAN; Fiscal Year: 2013..However it is not known whether cofilin is involved in Wnt signaling in vertebrates. This proposal aims to identify regulatory mechanisms governing cofilin and actin dynamics during neural crest ..
- The Molecular Genetics of Early NeurogenesisEthan Bier; Fiscal Year: 2013..In Drosophila and vertebrates alike, dorsal cells of the CNS form along the border of the BMP producing epidermis and express the Msx1 ..
- Regeneration of stereocilia of cochlear hair cellsDavid Z Z He; Fiscal Year: 2010..have demonstrated that lost hair cells can be replaced by production of new hair cells in birds and lower vertebrates. Hair cell regeneration is limited in mammals, but there is evidence to suggest that damaged hair cells may ..
- The Role of TAF4b in Spermatogonial Stem Cell Maintenance and Self-RenewalEric Gustafson; Fiscal Year: 2013..This new paradigm of germ cell-specific gene regulation is conserved between invertebrates and vertebrates, and may reflect an important mechanism for evolving germ cell-specific modes of gene regulation...
- Molecular genetics of epithelium formation in C. elegansStephen E Von Stetina; Fiscal Year: 2010..pathway that initiates epithelial polarization has been uncovered in many systems, including vertebrates. For example, the serine/threonine kinase LKB1 is sufficient to polarize single human intestine cells in the ..
- Defining Estrogenic Regulation of Hematopoietic Stem Cell Formation and FunctionTrista E North; Fiscal Year: 2013..Most genes involved in HSC formation are highly conserved across vertebrates, and continue to regulate HSC self-renewal and differentiation in the adult...
- Control of developmental timing and body size in DrosophilaMICHAEL BRENDAN O'CONNOR; Fiscal Year: 2013..transitions and thereby provide a paradigm for understanding how these processes might be regulated in vertebrates including humans...
- Mechanisms of Neural Crest Differentiation during Craniofacial DevelopmentVivian M Lee; Fiscal Year: 2010..One of the most prominent cell types in the craniofacial skeleton of vertebrates arises from a migratory stem cell population called the neural crest...
- The role of the primitive choana in amniote craniofacial morphogenesisJohn Abramyan; Fiscal Year: 2013..Despite their persistence in all vertebrates, very little focus has been placed on thi structure...
- Definition of an Ancient T cell-like System in LampreysMAX DALE COOPER; Fiscal Year: 2013..T- and B-like lymphocytes are basic features of the adaptive immune system of both jawless and jawed vertebrates, although jawless vertebrates (lampreys and hagfish) generate variable lymphocyte receptors (VLR) for antigen ..
- CELLULAR AND MOLECULAR BASES FOR RHYTHMIC GNRH RELEASESuzanne M Moenter; Fiscal Year: 2013..Episodic release of gonadotropin-releasing hormone (GnRH) is required for fertility in all vertebrates of both sexes, and frequency shifts are essential for female reproductive cycles...
- Regulation of tubulogenesis in the Drosophila ovaryCeleste A Berg; Fiscal Year: 2012..Synthesis of the dorsal respiratory appendages by the follicular epithelium resembles primary neurulation in vertebrates. The aberrant rearrangement of cells exhibited by G-protein mutants is similar to the tube-closure defects that ..
- Competetive Renewal of MSM: Multiscale Studies of Segmentation in VertebratesClaudio D Stern; Fiscal Year: 2013..Its emphasis on model and data share ability will promote efficient sharing of resources, tools and models among biomodelers and experimentalists, significantly reducing duplication of effort. ..
- Novel Model Systems Link Floridean Starch Metabolism to Lafora DiseaseMatthew S Gentry; Fiscal Year: 2010..phosphatase in Kingdom Animalia with a carbohydrate binding domain, regulates changes in glycogen metabolism in vertebrates and invertebrates...
- Development and Functional Analysis of Components of the Zebrafish Serotonin SignKenneth N Wallace; Fiscal Year: 2012..Enterochromaffin cells (EC) store about 95% of the serotonin within vertebrates. Mechanical and nutrient stimulation of EC cells results in basal 5-HT secretion into the submucosa...
- Analysis of Hair Cell Regeneration in ZebrafishALEJANDRO SANCHEZ ALVARADO; Fiscal Year: 2010..important transcription factors will be crucial for our understanding of how regeneration is triggered in lower vertebrates. Combined, these two approaches will discover key hair cell regeneration genes and set the stage for a ..
- Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination anUttiya Basu; Fiscal Year: 2013..Antibodies are polypeptide complexes produced from B-lymphocytes that are present in the bodily fluids of vertebrates, and are used by the immune system to identify and neutralize various foreign antigens...
- Melanin-Concentrating Hormone: Ancestral Role in Feeding & Sleep RegulationPhilippe Mourrain; Fiscal Year: 2010..neurons and is up-regulated upon fasting, suggesting a conservation of MCH2/hMCH regulation and function across vertebrates. However, while mammalian hypothalamus harbors thousands of MCH cells, zebrafish larval and adult brains ..
- Low-affinity aryl hydrocarbon receptors in the frog Xenopus laevisWade H Powell; Fiscal Year: 2010..general information about the toxicological and biological functions of this system in humans and other vertebrates. Understanding the differences between frog and human AHRs will also aid risk assessment by refining ..
- Using shared mechanisms of morphogenesis to study neural tube defectsJESSICA LEE SULLIVAN-BROWN; Fiscal Year: 2012..In vertebrates, mutations in approximately 200 genes lead to NTDs, but aside from a few important examples, most NTD genes ..
- East African Cichlids: A Natural Model for Dental RegenerationRYAN FREDRIC BLOOMQUIST; Fiscal Year: 2013..While we have learned a great deal from this system, in contrast to humans and most other vertebrates, the mouse lacks a successional or replacement set of teeth...
- Mechanisms of Sensory RegenerationMark Warchol; Fiscal Year: 2013..In contrast, the ears of nonmammalian vertebrates can quickly regenerate hair cells after injury, and it is of great interest to understand the cellular basis of ..
- "Gdf6 gene expression and evolution in vertebrates"Douglas Mortlock; Fiscal Year: 2009..These experiments will provide extensive insights into the conservation of this important signaling pathway gene in different animal models and the role genomic sequences play in normal skeletal patterning. ..
- Pre-osteoclast fusionPaul R Odgren; Fiscal Year: 2013..Both proteins are highly conserved in terrestrial vertebrates. In a model of acute, induced OC differentiation in an osteopetrotic rat model, we present preliminary evidence ..
- Mechanism of Apoptosis and Inhibition of Tumor Progression and Metastasis by Par-Vivek M Rangnekar; Fiscal Year: 2012..apoptosis response-4 protein (Par-4;also known as PAWR) is a leucine zipper domain protein that is conserved in vertebrates. During the previous funding period, we showed the core effector domain of Par-4 (amino acids 137-195, ..
- Reversible phosphorylation in Hedgehog signalingALAN ZHU; Fiscal Year: 2013..the mechanisms of how Hh signaling is precisely modulated by reversible phosphorylation, which will shed light on the role of PP2A as an effective therapeutic agent to prevent or treat Hh-related diseases in vertebrates.
- Regulated Retrotransposon Elements in Neuroendocrine SystemJanusz Puc; Fiscal Year: 2009..The pituitary gland is a critical component of the neuroendocrine system present in all vertebrates, and is essential in the maintenance of homeostasis, metabolism, reproduction, growth, and lactation...
- Retinal Cell-Fate Determination and Pattern FormationGraeme Mardon; Fiscal Year: 2012..of the retinal determination (RD) network, which is essential for normal development in both flies and vertebrates. Eya functions both as a transcriptional coactivator and a protein phosphatase while so encodes a homeodomain ..
- Gene-Expression Patterns During Hair-Cell RegenerationALBERT JAMES HUDSPETH; Fiscal Year: 2010..The structure, development, and operation of hair cells are conserved throughout the vertebrates. We accordingly anticipate that a detailed understanding of the molecular events underlying hair-cell ..
- Wnt Signaling in Hematopoietic Stem Cell Specification and LeukemiaWILSON KENDRICK CLEMENTS; Fiscal Year: 2013..cell-autonomous reception of a Notch signal in cells fated to become HSCs is an established requirement in vertebrates, the Notch signaling events regulated by DeltaC and DeltaD appear to be non-cell-autonomous and therefore ..
- Neural substrates for matching hearing to utteranceDarcy B Kelley; Fiscal Year: 2012..influence vocal output could derive from an ancient set of neural connections that have been elaborated in some vertebrates. If so, the forebrain/hindbrain, auditory/vocal system in Xenopus laevis should provide very interesting ..
- Cellular and molecular mechanisms of aging and regeneration in colonial chordateIrving L Weissman; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: In a colonial organism, Botryllus schlosseri, believed to be the link between vertebrates and invertebrates, weekly regeneration of individuals occurs via migration, proliferation, and self renewal by ..
- Gene Regulation of Cranial Sensory Placode DevelopmentSALLY ANN MOODY; Fiscal Year: 2013..different, powerful animal models will provide the strongest information for conserved gene regulation across vertebrates that will have the most relevance to human craniofacial syndromes...
- Oocyte polarity and mRNA localization in ZebrafishFLORENCE LOUISE MARLOW; Fiscal Year: 2013..by applicant): Asymmetry in oocytes is a well-documented and conserved feature among animals including vertebrates and humans...
- Regulation of cochlea hair cell differentiation by the Lin28b/let-7 axisErin Golden; Fiscal Year: 2013..While many vertebrates, including birds and reptiles, are able to regenerate damaged hair cells, mammals (including humans) do not ..
- Aging and Regeneration in a basal chordateAnthony W De Tomaso; Fiscal Year: 2013..Botryllus belongs to the phylum Tunicata, the sister group to the vertebrates. Besides this close phylogenetic relationship, Botryllus has a number of life history traits which make it an ..
- Identification of gene involved in late stage zebrafish craniofacial developmentREBECCA ANN ANDERSON; Fiscal Year: 2013DESCRIPTION (provided by applicant): The processes of bone formation, shared by all vertebrates, are often affected in human skeletal dysplasias, resulting in significant defects to craniofacial skeletogenesis...
- The Tunicate Ciona: A New Model for the Effects of Aging on Tissue RegenerationWilliam R Jeffery; Fiscal Year: 2013DESCRIPTION (provided by applicant): Many vertebrates have robust capacities for tissue regeneration as embryos and juveniles but this power fades during development and aging...
- ANALYSIS OF PROGRAMMED CELL DEATH IN FILAMENTOUS FUNGIN Louise Glass; Fiscal Year: 2013..Similar to other nonself recognition loci, such as the Major Histocompatibility Complex (MHC) in jawed vertebrates, het loci in N. crassa show evidence of balancing selection...
- Uncovering mechanisms controlling notochord vacuole and spine morphogenesisMichel Bagnat; Fiscal Year: 2013Abstract In vertebrates the notochord plays critical signaling roles during vertebrate development and acts as a hydrostatic skeleton for the embryo before bone formation...
- Basal Ganglia-Thalamic Interactions in Behaving Songbirds During LearningJESSE HEYMANN GOLDBERG; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: The basal ganglia are a set of brain nuclei highly conserved among vertebrates, including humans, critical for motor control and learning...
- ERV3 Control of Human PlacentationNEAL STEWART ROTE; Fiscal Year: 2013DESCRIPTION (provided by applicant): The genome of most vertebrates and some invertebrates has been transformed over millions of years by the integration of infectious retroviruses...
- Role of Shh-Hey1/Hey2 and Activin A in Hair Cell DifferentiationAna Benito-Gonzalez; Fiscal Year: 2013..While many vertebrates, including birds and reptiles, are able to regenerate damaged hair cells, mammals (including humans) do not ..
- Hydra: New Models for Aging ResearchSteven N Austad; Fiscal Year: 2013..Of particular note, a more distant ancestor to the vertebrates, the Cnidaria, have been discovered to contain a large number of obvious humans orthologs that are missing in ..
- Mechanisms of Cell Polarity EstablishmentIan G Macara; Fiscal Year: 2013..However, a Par3-related gene exists in vertebrates, which we discovered and named Par3L...
- 2013 Antimicrobial Peptides GRC/GRSGill Diamond; Fiscal Year: 2013..components of innate immunity used by all metazoans including bacteria, fungi, plants, invertebrates, vertebrates, and mammals including humans...
- IDENTIFYING GERMLINE GENES AS TARGETS FOR THERAPEUTIC INTERVENTION IN CANCERMary Lou King; Fiscal Year: 2013..difficult to isolate germ plasm in sufficient quantities for proten analysis and thus, genetic information in vertebrates has been limited...
- Connecting the proteome and transcriptome during regenerationKenro Kusumi; Fiscal Year: 2013DESCRIPTION (provided by applicant): Lizards are the most closely related vertebrates to mammals with the ability to regenerate an entire appendage as an adult...
- Transcriptional Regulation of Motor Neuron Subtype DevelopmentMADALYNN LEA ERB; Fiscal Year: 2013..Motor neuron circuits control respiration, coordinated movement and sympathetic nervous system activity in vertebrates. A promising treatment for motor neuron degenerative diseases is using cell therapies to replace lost motor ..
- Sensor Mechanisms of HSF ActivationEvgeny Nudler; Fiscal Year: 2013..HSF1 is constitutively expressed in vertebrates as inactive monomer under tight negative regulation...
- A protein-directed RNA switch that regulates translationPaul L Fox; Fiscal Year: 2013..We also speculate that the VEGF-A switch may represent the founding member of a family of protein-directed RNA switches in vertebrates that integrate physiological or pathological stimuli to control gene expression.
- The Role of SWI/SNF Alternative Splicing in CancerELAINE MARIE OBERLICK; Fiscal Year: 2013..SWI/SNF is an ATP-dependent nucleosome-remodeling complex conserved from yeast to mammals. In flies and vertebrates the complex is involved in development, differentiation, and is essential for the establishment and maintenance ..
- Adaptation of Staphylococcus aureus to Mn-limitation imposed by the hostTHOMAS EVERETT KEHL-FIE; Fiscal Year: 2013..A powerful strategy utilized by vertebrates to combat bacterial pathogens is the sequestration of essential nutrients, a process known as nutritional ..
- DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYOMary C Mullins; Fiscal Year: 2013..were found to exclusively signal in zebrafish DV patterning, providing an in vivo, physiological assay in vertebrates for BMP heterodimer signaling...
- Neuronal regulation of myelinationROMAN JENO GIGER; Fiscal Year: 2013DESCRIPTION (provided by applicant): In vertebrates, including humans, rapid neuronal communication in the peripheral (PNS) and central nervous system (CNS) is dependent on proper myelination...
- The Role of Muller Cells in Visual Pigment RegenerationGabriel H Travis; Fiscal Year: 2013..This result suggests that under daylight conditions, vertebrates (including humans) capture light energy in their retinas to regenerate visual chromophore...
- Identifying a transcriptional program that regulates compensatory proliferationJOY HART MESERVE; Fiscal Year: 2013..The results from these experiments will provide a comprehensive view of compensatory proliferation and will provide candidate genes that may be involved in regeneration and disease in vertebrates.
- 2013 Polyamines Gordon Research Conference and Gordon Research SeminarJohn L Cleveland; Fiscal Year: 2013..Thus, the GRC brings together top-notch researchers who study polyamines in several organisms (vertebrates, yeast, plants, protozoa and bacteria) with those assessing therapeutic applications...
- Role of molecular recognition in retinal patterning and synaptic organizationPETER GERARD FUERST; Fiscal Year: 2013..to ablate mosaic patterning and the first genes shown to mediate isoneuronal and heteroneuronal repulsion in vertebrates. Specific Aims: We propose to use the Dscam and Dscaml1 mutant mouse models to discover mechanisms underpinning ..
- Effects of insulin-like signaling, aging, and ubiquinone on C. elegans muscleAlfred L Fisher; Fiscal Year: 2013..Additionally, complex I activity in muscle and other tissues declines during aging in vertebrates. These findings led us to hypothesize that mitochondrial activity is a driver of the development of sarcopenia ..
- Imaging the struggle for nutrient metal between host and pathogenEric P Skaar; Fiscal Year: 2013..b>Vertebrates have taken advantage of this requirement by evolving high-affinity metal binding proteins that sequester metals ..
- The Genetics and Evolution of Extreme Body Size in Mice from Gough IslandBret A Payseur; Fiscal Year: 2013..Island vertebrates are often unusually large or small compared to their mainland relatives...
- Behavior-based chemical screening for GABAergic and startle modifying drugsDavid Kokel; Fiscal Year: 2013..Unlike larger vertebrates, zebrafish are small enough to be easily arrayed in the individual wells of a 96-well plate along with ..
- Molecular Interactions During Neural Crest FormationMARTIN IGNACIO GARCIA-CASTRO; Fiscal Year: 2013..This work will illuminate fundamental principles of neural crest formation in higher vertebrates (birds and mammals), and will invigorate human neural crest studies.
- Nitrogen Metabolism in Aedes Aegypti MosquitoesPATRICIA YOLANDA SCARAFFIA; Fiscal Year: 2013..Mosquitoes can also use the nitrogen from the amide group of glutamine to produce uric acid as vertebrates do, and more surprisingly, mosquitoes hydrolyze uric acid into urea through the same metabolic pathway that ..
- Quasispecies dynamics in arbovirus persistence emergence and fitnessGREGORY DAVID EBEL; Fiscal Year: 2013..The frequency of contact between mosquitoes and vertebrates varies in time and space...
- Mechanism of vertebrate neural tube morphogenesisJohn B Wallingford; Fiscal Year: 2013..The central nervous system of vertebrates develops initially as a flat sheet of cells that will roll up and seal shut to form the hollow neural tube...
- Functions of Heparan Sulfate Proteoglycans in Axon Guidance and Degeneration.FABIENNE POULAIN; Fiscal Year: 2013..While appealing, this "sugar code" hypothesis is still theoretial and has not been tested in vertebrates. Moreover, the contribution of the core proteins carrying these specific HS patterns is not known...
- Ontogeny of the Phase II cytosolic sulfotransferases and adverse drug reactionsMing Cheh Liu; Fiscal Year: 2013..In humans and other vertebrates, sulfation as mediated by the SULTs is known to play a major role in the detoxification of xenobiotics...
- Developing tools for understanding neuromodulation of hypothalamic funcSu Guo; Fiscal Year: 2013..factor (CRF) and pituitary pro-opiomelanocortin (POMC) neurons are evolutionarily conserved across vertebrates. They control organismal responses to aversive stimuli through regulating circulating neuropeptides and ..