- Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
Laboratory of Molecular Neuroscience, Heidelberg University, Federal Republic of Germany
Neuron 12:529-40. 1994
..Thus, the distinct expression profiles and functional properties of NR2 subunits provide a basis for NMDA channel heterogeneity in the brain...
- Innate immunity of the newborn: basic mechanisms and clinical correlates
Department of Medicine, Division of Infectious Diseases, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Nat Rev Immunol 7:379-90. 2007
..This Review describes innate immunity in newborns and discusses how this knowledge might be used to prevent and treat infection in this vulnerable population...
- Mosaic organization of neural stem cells in the adult brain
Florian T Merkle
Department of Neurosurgery and Developmental and Stem Cell Biology Program, University of California, San Francisco, San Francisco, CA 94143 0525, USA
Science 317:381-4. 2007
..This suggests that rather than being plastic and homogeneous, neural stem cells are a restricted and diverse population of progenitors...
- Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
Mark S Ansorge
Sackler Institute for Developmental Psychobiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Science 306:879-81. 2004
- Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Goettingen D 37077, Germany
Genes Dev 14:2701-11. 2000
- Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
Danielle L Champagne
Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
J Neurosci 28:6037-45. 2008
- A murine oral enterovirus 71 infection model with central nervous system involvement
Yi Chun Chen
Department of Microbiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
J Gen Virol 85:69-77. 2004
..Leukocyte infiltration was evident in the spinal cord and brain stem. Furthermore, EV71 virus could be transmitted to littermates within the same cage...
- Lifespan: catch-up growth and obesity in male mice
Susan E Ozanne
Department of Clinical Biochemistry, University of Cambridge, Cambridge, CB2 2QR, UK
Nature 427:411-2. 2004
- Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons
Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010 2970, USA
J Cell Biol 161:169-86. 2003
..These data show that at least a subpopulation of postnatal NG2-expressing cells are CNS multipotent precursors that may underlie adult hippocampal neurogenesis...
- Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2
Gary A Wayman
Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
Neuron 50:897-909. 2006
..This novel signaling pathway contributes to dynamic remodeling of the dendritic architecture in response to neuronal activity during development...
- VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Deparrment of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
J Cell Biol 161:1163-77. 2003
..Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells...
- Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection
Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
J Neurosci 25:4279-87. 2005
..Thus, activity-dependent neuroprotection comprises two mechanistically distinct phases that differ in their spatial requirements for calcium and in their reliance on the CREB family...
- Postsynaptic expression of homeostatic plasticity at neocortical synapses
Corette J Wierenga
Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454 9110, USA
J Neurosci 25:2895-905. 2005
- Vesicular glutamate transporters in the spinal cord, with special reference to sensory primary afferent synapses
Francisco J Alvarez
Department of Anatomy and Physiology, Wright State University, Dayton, Ohio 45435, USA
J Comp Neurol 472:257-80. 2004
..These results indicate a diversity of VGLUT isoform combinations expressed in different spinal primary afferents...
- Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry
Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
Neuropsychopharmacology 31:47-57. 2006
..It is not known whether this effect of SSRIs is paralleled in humans; however, these data suggest that in utero, exposure to SSRIs may have unforeseen long-term neurobehavioral consequences...
- Transforming growth factor beta (TGFbeta) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFbeta-mediated death to Schwann cell differentiation
D B Parkinson
Department of Anatomy, University College London, London WC1E 6BT, United Kingdom
J Neurosci 21:8572-85. 2001
- Co-expression of de novo DNA methyltransferases Dnmt3a2 and Dnmt3L in gonocytes of mouse embryos
Department of Anatomy, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
Gene Expr Patterns 5:231-7. 2004
..The results strongly suggest that Dnmt3a2 and Dnmt3L are responsible for the global DNA methylation in mouse male germ cells...
- BAX is required for neuronal death after trophic factor deprivation and during development
T L Deckwerth
Department of Molecular Biology and Pharmacology, Howard Hughes Medical Institute Washington University School of Medicine, St Louis, Missouri 63110, USA
Neuron 17:401-11. 1996
..Bax-deficient superior cervical ganglia and facial nuclei possessed increased numbers of neurons. Our observations demonstrate that trophic factor deprivation-induced death of sympathetic and motor neurons depends on Bax...
- Transient and persistent dendritic spines in the neocortex in vivo
Anthony J G D Holtmaat
Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Neuron 45:279-91. 2005
..In 6-month-old mice, spines turn over more slowly in visual compared to somatosensory cortex, possibly reflecting differences in the capacity for experience-dependent plasticity in these brain regions...
- Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis
G V Putcha
Departments of Neurology and Molecular Biology and Pharmacology, Washington University School of Medicine, Saint Louis, MO 63110, USA
Neuron 29:615-28. 2001
- Long-term fate and distribution of newborn cells in the adult mouse olfactory bulb: Influences of olfactory deprivation
Laboratoire de Neurosciences et Systèmes Sensoriels, CNRS UMR 5020, Universite Claude Bernard Lyon 1, 50 avenue Tony Garnier, 6936, Lyon Cedex 07, France
Neuroscience 141:443-51. 2006
..In addition, our data suggest a functional heterogeneity of neurogenesis within the granular layer...
- Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo
MGH HMS Center for Nervous System Repair, Departments of Neurosurgery and Neurology, Program in Neuroscience and Harvard Stem Cell Institute, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Neuron 45:207-21. 2005
- Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain
Ansgar M Brambrink
Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
Anesthesiology 112:834-41. 2010
..Therefore, we exposed postnatal day 6 (P6) rhesus macaques to a surgical plane of isoflurane anesthesia for 5 h, and studied the brains 3 h later for histopathologic changes...
- c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice
Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, INF 307, D 69120 Heidelberg, Germany
Eur J Neurosci 20:353-62. 2004
..ChAT) and the vesicular acetylcholine transporter (VAChT) in stellate ganglia of homozygous newborn animals. The number of neurons positive for tyrosine hydroxylase (TH) mRNA, the rate-limiting enzyme of noradrenaline ..
- Neonatal exposure to bisphenol a alters reproductive parameters and gonadotropin releasing hormone signaling in female rats
Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
Environ Health Perspect 117:757-62. 2009
..Several reports have revealed potent in vivo effects, because BPA acts as an estrogen agonist and/or antagonist and as an androgen and thyroid hormone antagonist...
- The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
O F Bueno
Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
EMBO J 19:6341-50. 2000
..The results of the present study indicate that the MEK1-ERK1/2 signaling pathway stimulates a physiologic hypertrophy response associated with augmented cardiac function and partial resistance to apoptotsis...
- The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia
Kuei Y Tseng
Department of Cellular and Molecular Pharmacology, RFUMS The Chicago Medical School, North Chicago, IL 60064, USA
Behav Brain Res 204:295-305. 2009
- Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase
S F Kash
Department of Medicine, School of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 94:14060-5. 1997
- Brain injury and neurofunctional deficit in neonatal mice with hypoxic-ischemic encephalopathy
Vadim S Ten
Department of Pediatrics, Columbia University, 3959 Broadway, BHS 12, Room 115, New York, NY 10032, USA
Behav Brain Res 145:209-19. 2003
- Protection of neonatal mice from lethal enterovirus 71 infection by maternal immunization with attenuated Salmonella enterica serovar Typhimurium expressing VP1 of enterovirus 71
Cheng Hsun Chiu
Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan 333, Taiwan
Microbes Infect 8:1671-8. 2006
..Our data indicated that Salmonella-based VP1 subunit vaccines are a promising vaccine strategy in the prevention of EV71 infection...
- Perlecan is essential for cartilage and cephalic development
Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
Nat Genet 23:354-8. 1999
..Our findings suggest that these molecules affect similar signalling pathways...
- Manipulation of antioxidant pathways in neonatal murine brain
R Ann Sheldon
Department of Neurology, University of California San Francisco, San Francisco, California 94143
Pediatr Res 56:656-62. 2004
..008). These findings support the hypothesis that the immature brain has limited GPX activity and is more susceptible to oxidative damage and may explain the paradoxical effect seen in ischemic neonatal brain when SOD1 is overexpressed...
- Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells
Helene C Dujardin
Unité du Développement des Lymphocytes, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1961, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Proc Natl Acad Sci U S A 101:14473-8. 2004
..This study demonstrates that the peripheral immune system of newborn mice is endowed of a remarkable regulatory potential, which develops considerably in the absence of thymic supply...
- Notch signaling contributes to the expression of cardiac markers in human circulating progenitor cells
Department of Molecular Cardiology, Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Circ Res 101:1139-45. 2007
..Gamma-secretase-dependent Notch activation is required for cardiac gene expression in human cells and induces the expression of noncanonical Wnt proteins, which may act in a paracrine manner to further amplify cardiac differentiation...
- Null mutation in the desmin gene gives rise to a cardiomyopathy
Department of Anatomy, Umea University, Umea, Sweden
J Mol Cell Cardiol 29:2107-24. 1997
..Thus, the intermediate filaments are required to maintain the basic integrity of cardiomyocytes and especially the link between the intermediate filaments and the sarcolemma appear more important than previously realized...
- Developmental regulation of spontaneous activity in the Mammalian cochlea
Nicolas X Tritsch
The Solomon H Snyder Department of Neuroscience and Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21205, USA
J Neurosci 30:1539-50. 2010
..These results suggest that supporting cells in the cochlea provide the primary excitatory stimulus responsible for initiating bursts of action potentials in auditory nerve fibers before the onset of hearing...
- alpha3beta1 Integrin is required for normal development of the epidermal basement membrane
C M DiPersio
Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
J Cell Biol 137:729-42. 1997
..Our findings support a novel role for alpha3beta1 in establishment and/or maintenance of basement membrane integrity, while alpha6beta4 is required for stable adhesion of the epidermis to the basement membrane through hemidesmosomes...
- Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults
David F Wozniak
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Neurobiol Dis 17:403-14. 2004
..We hypothesize that neuroapoptotic damage in homologous regions of human brain underlies cognitive deficits in FAS and the human brain of FAS victims has a similar capacity to effect functional recovery...
- Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry
Timothy J M Moss
School of Women s and Infants Health and Centre for Child Health Research, University of Western Australia, Perth, Australia
Am J Respir Crit Care Med 165:805-11. 2002
- p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate
Elizabeth J Coulson
Queensland Brain Institute and School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
J Neurosci 28:315-24. 2008
..Our results demonstrate a novel mode of activation of GIRK channels, representing an early step in the p75(NTR)-mediated cell death pathway and suggesting a function for these channels during nervous system development...
- Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity
Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
J Neurosci 26:2380-90. 2006
..Together, our findings indicate that the lipid binding of the PICK1 BAR domain is important for its synaptic targeting, AMPA receptor trafficking, and synaptic plasticity...
- Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance
Department of Biochemistry, Faculty of Pharmacy, Universidad Complutense, 28040 Madrid, Spain
Diabetes 56:404-13. 2007
..However, mice lacking PTP1B maintained a rapid clearance of glucose and insulin sensitivity and displayed normal muscle insulin signaling regardless the presence of TNF-alpha...
- Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia
Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Neurosci Res 81:403-11. 2005
..Collectively, these results raise the possibility that PPAR-alpha and RXR agonists might have benefit as a therapy in MS, where activated microglia are believed to contribute to disease pathology...
- Early postnatal development of spontaneous and acoustically evoked discharge activity of principal cells of the medial nucleus of the trapezoid body: an in vivo study in mice
Faculty of Bioscience, Pharmacy, and Psychology, University of Leipzig, Leipzig, Germany
J Neurosci 29:9510-20. 2009
..These data emphasize that models of signal transmission at the calyx of Held based on in vitro data have to take developmental changes in firing rates and response latencies up to the fourth postnatal week into account...
- Developmental changes in spontaneous smooth muscle activity in the neonatal rat urinary bladder
Eniko A Szell
Department of Pharmacology, University of Pittsburgh, Pennsylvania 15261, USA
Am J Physiol Regul Integr Comp Physiol 285:R809-16. 2003
..The emergence of faster activity in bladders from older animals may reflect the development of multiple pacemaker sites, which would reduce coordination within the bladder wall and improve storage function in the mature bladder...
- Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells
MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK
Development 125:557-66. 1998
..These findings suggest that myosin VIIA is required for normal stereocilia bundle organisation and has a role in the function of cochlear hair cells...
- NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, 44106, USA
Dev Biol 210:411-27. 1999
..5 but does alter axon outgrowth and decrease salivary gland innervation. Taken together these results suggest that neurotrophin-3 is required for survival of some sympathetic neurons that also require nerve growth factor...
- Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts
Department of Pathology, Children s Memorial Hospital, Northwestern University Medical School, 2300 Children s Plaza, Chicago, IL 60614, USA
Pediatr Dev Pathol 6:6-23. 2003
..The former maintains intestinal perfusion and the integrity of the mucosal barrier, and the latter keep virulent bacteria in check. The development of tissue injury depends on the balance between injurious and protective mechanisms...
- Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival
D Joshua Cameron
Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
Int J Biol Sci 3:111-9. 2007
..These results implicate the importance of these long chain fatty acids in skin barrier development. Furthermore, we suggest that Elovl4 is likely involved in the elongation of C26 and longer fatty acids...
- Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis
Universite de Caen, CNRS UMR 6551, Bd H Becquerel, B P 5229, 14074 Caen Cedex, France
Mol Cell Neurosci 21:634-44. 2002
..Overall, this study underlines the critical role of the t-PA/PAI-1 axis in the regulation of glutamatergic neurotransmission...
- A common mechanism of action for three mood-stabilizing drugs
Robin S B Williams
Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK
Nature 417:292-5. 2002
..Inhibitors of prolyl oligopeptidase reverse the effects of all three drugs on sensory neuron growth cone area and collapse. These results suggest a molecular basis for both bipolar affective disorder and its treatment...
- Tissue engineering of a differentiated cardiac muscle construct
W H Zimmermann
Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
Circ Res 90:223-30. 2002
..The data indicate that EHTs represent highly differentiated cardiac tissue constructs, making EHTs a promising material for in vitro studies of cardiac function and tissue replacement therapy...
- Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs. aged rats
Jason K Wasserman
Toronto Western Research Institute, University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, Canada
Eur J Neurosci 28:1316-28. 2008
..These findings have important implications for efforts to reduce secondary injury after ICH and to develop anti-inflammatory therapies to treat ICH in aged humans...
- Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice
Institut de Pharmacologie et de Toxicologie de l Université, Lausanne, Switzerland
Nat Genet 12:325-8. 1996
..Alpha-ENaC(-/-) neonates developed respiratory distress and died within 40 h of birth from failure to clear their lungs of liquid. This study shows that ENaC plays a critical role in the adaptation of the newborn lung to air breathing...
- The neural substrates of infant sleep in rats
Karl A E Karlsson
Program in Behavioral and Cognitive Neuroscience, Department of Psychology, University of Iowa, Iowa City, USA
PLoS Biol 3:e143. 2005
- GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation
Doris D Wang
Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 28:5547-58. 2008
..Our study identifies an essential role for GABA in the synaptic integration of newborn cortical neurons and suggests an activity-dependent mechanism for achieving the balance between excitation and inhibition in the developing cortex...
- The role of autophagy during the early neonatal starvation period
Time s Arrow and Biosignaling, PRESTO, Japan Science and Technology Agency, Kawaguchi 332 0012, Japan
Nature 432:1032-6. 2004
..These results suggest that the production of amino acids by autophagic degradation of 'self' proteins, which allows for the maintenance of energy homeostasis, is important for survival during neonatal starvation...
- Infant vocalization, adult aggression, and fear behavior of an oxytocin null mutant mouse
J T Winslow
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Horm Behav 37:145-55. 2000
..We conclude that the absence of exposure to OT during development was associated with abnormalities in the development of emotional behavior...
- An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons
CV Starr Laboratory for Molecular Neuropharmacology, Department of Anesthesiology, Weill Medical College, Cornell University, New York, NY 10021, USA
J Neurophysiol 94:4491-501. 2005
..In view of the critical role of thalamic neurons in the generation of oscillatory activity associated with sleep, these receptors may represent a principal site of action for the novel hypnotic agent gaboxadol...
- Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death
Department of Toxicology, University of Hamburg Medical School, Germany
Cell 71:369-82. 1992
- Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma
Department of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurosci Res 77:540-51. 2004
- Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells
M C Ryan
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
J Cell Biol 145:1309-23. 1999
..These results indicate that laminin 5 has an important role in regulating tissue organization, gene expression, and survival of epithelium...
- Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
J Clin Invest 114:322-9. 2004
..Thus, IFN-gamma-driven obstruction of bile ducts is a key pathogenic mechanism of disease and may constitute a therapeutic target to block disease progression in patients with biliary atresia...
- A novel functional neuron group for respiratory rhythm generation in the ventral medulla
Showa University School of Medicine, Shinagawa ku, Tokyo 142 8555, Japan
J Neurosci 23:1478-86. 2003
..Our findings suggest that the pFRG comprises a neuronal population that is involved in the primary respiratory rhythm generation in the rostrocaudally extending respiratory neuron network of the medulla...
- Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood
Fiona J Culley
Department of Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, London W2 1PG, United Kingdom
J Exp Med 196:1381-6. 2002
..Thus, simply delaying RSV infection beyond infancy might reduce subsequent respiratory morbidity in later childhood...
- Neonatal bisphenol-a exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons
Heather B Adewale
Department of Biology, North Carolina State University, Raleigh, North Carolina, USA
Biol Reprod 81:690-9. 2009
..Our data suggest that BPA disrupts ovarian development but not the ability of GnRH neurons to respond to steroid-positive feedback...
- Differential role of N-type calcium channel splice isoforms in pain
Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 1N4
J Neurosci 27:6363-73. 2007
..In contrast, both N-type channel isoforms (e37a- and e37b-containing) contribute to tactile neuropathic allodynia. Hence, exon 37a acts as a molecular switch that tailors the channels toward specific roles in pain...
- Selective adaptation in networks of cortical neurons
Faculties of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
J Neurosci 23:9349-56. 2003
..The observation that selective adaptation arises naturally in a network of cortical neurons developing ex vivo indicates that this is an inherent feature of spontaneously organizing cortical networks...
- A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Nat Genet 36:1111-6. 2004
..Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated...
- Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia
Yoon Seong Kim
Burke Medical Research Institute, Weill Medical College and Graduate School of Medical Sciences of Cornell University, White Plains, New York 10605, USA
J Neurosci 25:3701-11. 2005
..Therefore, the release of MMP-3 from apoptotic neurons may play a major role in degenerative human brain disorders, such as Parkinson's disease...
- Local sharing as a predominant determinant of synaptic matrix molecular dynamics
The Rappaport Family Institute for Research in the Medical Sciences, Technion Faculty of Medicine, Haifa, Israel
PLoS Biol 4:e271. 2006
- Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin
Lawson Health Research Institute, St Joseph s Health Care, London, Ontario, Canada
Endocrinology 147:2346-56. 2006
..The target cells of GLP-1 probably include immature beta-cells that coexpress proglucagon...
- Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2
Jeremy A Cholfin
Medical Scientist Training Program, University of California, San Francisco, San Francisco, California 94143 2611, USA
J Comp Neurol 509:144-55. 2008
..We have integrated our results to propose a model for how fibroblast growth factors regulate FC patterning through regulation of regional transcription factor expression within the FC anlage...
- Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin
Division of Pediatric Hematology Oncology, Department of Pediatrics, University of Utah, Salt Lake City, Utah 84112, USA
Genes Dev 18:2608-13. 2004
- Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2
Antonio Carlos Pinheiro de Oliveira
Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
Glia 56:844-55. 2008
- A twist code determines the onset of osteoblast differentiation
Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Dev Cell 6:423-35. 2004
..In vivo mutagenesis confirms the antiosteogenic function of the Twist box. Thus, relief of inhibition by Twist proteins is a mandatory event precluding osteoblast differentiation...
- Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats
Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84158, USA
Physiol Genomics 25:16-28. 2006
..Despite these differences, caloric, fat, and protein content were similar in breast milk from Con and IUGR dams. We conclude that IUGR results in postnatal changes in cerebral chromatin structure and that these changes are sex specific...
- Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex
R H Baloh
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Neuron 21:1291-302. 1998
- Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function
Department of Dermatology, Columbia University, New York, NY, USA
J Cell Sci 119:4901-12. 2006
..The functional defects in Arnt-null mouse epidermis underscore the crucial role of Arnt in the maintenance of epidermal homeostasis, especially during the perinatal transition to the ex utero environment...
- Retinal progenitor cell xenografts to the pig retina: morphologic integration and cytochemical differentiation
Department of Ophthalmology, Lund University Hospital, Lund, Sweden
Arch Ophthalmol 123:1385-93. 2005
..To investigate the survival, integration, and differentiation of mouse retinal progenitor cells after transplantation to the subretinal space of adult pigs...
- Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
Peter D Gluckman
Liggins Institute, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
Proc Natl Acad Sci U S A 104:12796-800. 2007
- Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes
N H Purcell
Ben May Institute for Cancer Research and the Committee on Cancer Biology, University of Chicago, 5841 South Maryland Avenue, MC6027, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 98:6668-73. 2001
..These findings suggest that NF-kappaB plays a critical role in the hypertrophic growth of cardiomyocytes and may serve as a potential target for the intervention of heart disease...
- Minocycline decreases in vitro microglial motility, beta1-integrin, and Kv1.3 channel expression
Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
J Neurochem 103:2035-46. 2007
- Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors
Christopher L Antos
Department of Molecular Biology, The University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
J Biol Chem 278:28930-7. 2003
..HDAC inhibitors are currently being tested in clinical trials as anti-cancer agents. Our results suggest that these inhibitors may also hold promising clinical value as therapeutics for cardiac hypertrophy and heart failure...
- A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules
Department of Biological Sciences, Imperial College London, London SW7 2AZ, England, UK
J Cell Biol 164:243-53. 2004
..Our data indicate a bifurcation in the so-called canonical WNT-signaling pathway to regulate microtubule stability...
- Electroporation and RNA interference in the rodent retina in vivo and in vitro
Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:16-22. 2004
..Plasmid DNA was also efficiently transfected into retinal explants in vitro by high-voltage pulses...
- Early motor activity drives spindle bursts in the developing somatosensory cortex
INMED, INSERM U29, Avenue de Luminy, B P 13, 13273 Marseille, France
Nature 432:758-61. 2004
..We suggest that the interaction between movement-triggered sensory feedback signals and self-organized spindle oscillations shapes the formation of cortical connections required for sensorimotor coordination...
- Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): suppression of receptor-evoked calcium signaling and control of release function
Department of Cellular Neurosciences, Max Delbruck Center for Molecular Medicine, D 13092 Berlin, Germany
J Neurosci 23:4410-9. 2003
..Elevation of basal [Ca 2+]i could thus prove a central element in the regulation of executive functions in activated microglia...
- Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis
Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA
Oncogene 21:3765-79. 2002
..This study demonstrates that Matriptase/MT-SP1 has pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system...
- A single intravenous injection of adeno-associated virus serotype-9 leads to whole body skeletal muscle transduction in dogs
Department of Molecular Microbiology and Immunology, School of Medicine, The University of Missouri, Columbia, Missouri 65212, USA
Mol Ther 16:1944-52. 2008
..In particular, cardiac muscle was barely transduced in dogs. Many muscular dystrophy patients can be identified by neonatal screening. The technology described here may lead to an effective early intervention in these patients...
- Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long-Evans rats
Rollins Research Centre, Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Room 5074, Atlanta, GA 30322, USA
Pharmacol Biochem Behav 73:131-40. 2002
..Therefore, experiencing maternal separation results in a long-lasting increase in anxiety-like behaviors that occurs in a sex-dependent manner...
- Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex
Department of Neurology, Harvard Medical School and Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
J Comp Neurol 479:168-80. 2004
..The patterns of expression of Cux genes suggest potential roles as determinants of the neuronal fate of the upper cortical layer neurons...
- Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions
Department of Development and Genetics, Evolution Biology Centre, Uppsala University, Norbyvagen 18A, SE 752 36 Uppsala, Sweden
Nat Genet 38:1341-7. 2006
..These observations shed new light on development, cancer epigenetics and the evolution of imprinting...
- Physiological development of insulin secretion, calcium channels, and GLUT2 expression of pancreatic rat beta-cells
Department of Biophysics, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
Am J Physiol Endocrinol Metab 292:E1018-29. 2007
- Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors
Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
Neuron 63:48-62. 2009
- Desmin is essential for the tensile strength and integrity of myofibrils but not for myogenic commitment, differentiation, and fusion of skeletal muscle
Station Centrale de Microscopie Electronique, Institut Pasteur, Paris, France
J Cell Biol 139:129-44. 1997
..The results presented here show that desmin is essential to maintain the structural integrity of highly solicited skeletal muscle...
- Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis
Department of Neurochemistry, National Institute of Neuroscience, Kodaira, Tokyo 187 8502, Japan
Glia 55:604-16. 2007
..These results indicate that P2X(4)R as well as P2Y(12)R is involved in ATP-induced microglial chemotaxis...
- Smooth-muscle contraction without smooth-muscle myosin
Max Delbrück Center for Molecular Medicine MDC, Robert Rössle Strabe 10, D 13092 Berlin, Germany
Nat Cell Biol 2:371-5. 2000
..We conclude that phase 1 becomes indispensable for survival and normal growth soon after birth, particularly for functions such as homeostasis and circulation...
- Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes
Department of Biomedical Sciences and Venetian Institute for Molecular Medicine, University of Padua, Via Orus 2, 35129 Padua, Italy
Science 295:1711-5. 2002
..Furthermore, we demonstrate that such gradients of cAMP specifically activate a subset of protein kinase A molecules anchored in proximity to the T tubule...
- Dlx5 regulates regional development of the branchial arches and sensory capsules
M J Depew
Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience, Developmental Biology, Oral Biology and Biomedical Sciences, University of California at San Fran
Development 126:3831-46. 1999
- Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartment
Anthony D Tramontin
Department of Neurosurgery Research, University of California, San Francisco, CA 94143, USA
Cereb Cortex 13:580-7. 2003
..We propose that a VZ 'compartment' is retained postnatally and that this niche may be essential for stem cell function...