newborn animals

Summary

Top Publications

  1. ncbi Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
    H Monyer
    Laboratory of Molecular Neuroscience, Heidelberg University, Federal Republic of Germany
    Neuron 12:529-40. 1994
  2. ncbi Innate immunity of the newborn: basic mechanisms and clinical correlates
    Ofer Levy
    Department of Medicine, Division of Infectious Diseases, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Nat Rev Immunol 7:379-90. 2007
  3. ncbi Mosaic organization of neural stem cells in the adult brain
    Florian T Merkle
    Department of Neurosurgery and Developmental and Stem Cell Biology Program, University of California, San Francisco, San Francisco, CA 94143 0525, USA
    Science 317:381-4. 2007
  4. ncbi Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
    Mark S Ansorge
    Sackler Institute for Developmental Psychobiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Science 306:879-81. 2004
  5. pmc Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    R Ashery-Padan
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Goettingen D 37077, Germany
    Genes Dev 14:2701-11. 2000
  6. ncbi Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    Danielle L Champagne
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 28:6037-45. 2008
  7. ncbi A murine oral enterovirus 71 infection model with central nervous system involvement
    Yi Chun Chen
    Department of Microbiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Gen Virol 85:69-77. 2004
  8. ncbi Lifespan: catch-up growth and obesity in male mice
    Susan E Ozanne
    Department of Clinical Biochemistry, University of Cambridge, Cambridge, CB2 2QR, UK
    Nature 427:411-2. 2004
  9. pmc Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons
    Shibeshih Belachew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010 2970, USA
    J Cell Biol 161:169-86. 2003
  10. ncbi Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2
    Gary A Wayman
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Neuron 50:897-909. 2006

Detail Information

Publications287 found, 100 shown here

  1. ncbi Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
    H Monyer
    Laboratory of Molecular Neuroscience, Heidelberg University, Federal Republic of Germany
    Neuron 12:529-40. 1994
    ..Thus, the distinct expression profiles and functional properties of NR2 subunits provide a basis for NMDA channel heterogeneity in the brain...
  2. ncbi Innate immunity of the newborn: basic mechanisms and clinical correlates
    Ofer Levy
    Department of Medicine, Division of Infectious Diseases, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Nat Rev Immunol 7:379-90. 2007
    ..This Review describes innate immunity in newborns and discusses how this knowledge might be used to prevent and treat infection in this vulnerable population...
  3. ncbi Mosaic organization of neural stem cells in the adult brain
    Florian T Merkle
    Department of Neurosurgery and Developmental and Stem Cell Biology Program, University of California, San Francisco, San Francisco, CA 94143 0525, USA
    Science 317:381-4. 2007
    ..This suggests that rather than being plastic and homogeneous, neural stem cells are a restricted and diverse population of progenitors...
  4. ncbi Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice
    Mark S Ansorge
    Sackler Institute for Developmental Psychobiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Science 306:879-81. 2004
    ....
  5. pmc Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    R Ashery-Padan
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Goettingen D 37077, Germany
    Genes Dev 14:2701-11. 2000
    ....
  6. ncbi Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
    Danielle L Champagne
    Swammerdam Institute for Life Sciences Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 28:6037-45. 2008
    ....
  7. ncbi A murine oral enterovirus 71 infection model with central nervous system involvement
    Yi Chun Chen
    Department of Microbiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Gen Virol 85:69-77. 2004
    ..Leukocyte infiltration was evident in the spinal cord and brain stem. Furthermore, EV71 virus could be transmitted to littermates within the same cage...
  8. ncbi Lifespan: catch-up growth and obesity in male mice
    Susan E Ozanne
    Department of Clinical Biochemistry, University of Cambridge, Cambridge, CB2 2QR, UK
    Nature 427:411-2. 2004
    ....
  9. pmc Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons
    Shibeshih Belachew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010 2970, USA
    J Cell Biol 161:169-86. 2003
    ..These data show that at least a subpopulation of postnatal NG2-expressing cells are CNS multipotent precursors that may underlie adult hippocampal neurogenesis...
  10. ncbi Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2
    Gary A Wayman
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Neuron 50:897-909. 2006
    ..This novel signaling pathway contributes to dynamic remodeling of the dendritic architecture in response to neuronal activity during development...
  11. pmc VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
    Holger Gerhardt
    Deparrment of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, Box 440, SE 405 30 Goteborg, Sweden
    J Cell Biol 161:1163-77. 2003
    ..Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells...
  12. ncbi Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection
    Sofia Papadia
    Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, United Kingdom
    J Neurosci 25:4279-87. 2005
    ..Thus, activity-dependent neuroprotection comprises two mechanistically distinct phases that differ in their spatial requirements for calcium and in their reliance on the CREB family...
  13. ncbi Postsynaptic expression of homeostatic plasticity at neocortical synapses
    Corette J Wierenga
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 25:2895-905. 2005
    ....
  14. ncbi Vesicular glutamate transporters in the spinal cord, with special reference to sensory primary afferent synapses
    Francisco J Alvarez
    Department of Anatomy and Physiology, Wright State University, Dayton, Ohio 45435, USA
    J Comp Neurol 472:257-80. 2004
    ..These results indicate a diversity of VGLUT isoform combinations expressed in different spinal primary afferents...
  15. pmc Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry
    Dorota Maciag
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA
    Neuropsychopharmacology 31:47-57. 2006
    ..It is not known whether this effect of SSRIs is paralleled in humans; however, these data suggest that in utero, exposure to SSRIs may have unforeseen long-term neurobehavioral consequences...
  16. ncbi Transforming growth factor beta (TGFbeta) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFbeta-mediated death to Schwann cell differentiation
    D B Parkinson
    Department of Anatomy, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 21:8572-85. 2001
    ....
  17. ncbi Co-expression of de novo DNA methyltransferases Dnmt3a2 and Dnmt3L in gonocytes of mouse embryos
    Yasuhiro Sakai
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara 228 8555, Japan
    Gene Expr Patterns 5:231-7. 2004
    ..The results strongly suggest that Dnmt3a2 and Dnmt3L are responsible for the global DNA methylation in mouse male germ cells...
  18. ncbi BAX is required for neuronal death after trophic factor deprivation and during development
    T L Deckwerth
    Department of Molecular Biology and Pharmacology, Howard Hughes Medical Institute Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 17:401-11. 1996
    ..Bax-deficient superior cervical ganglia and facial nuclei possessed increased numbers of neurons. Our observations demonstrate that trophic factor deprivation-induced death of sympathetic and motor neurons depends on Bax...
  19. ncbi Transient and persistent dendritic spines in the neocortex in vivo
    Anthony J G D Holtmaat
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 45:279-91. 2005
    ..In 6-month-old mice, spines turn over more slowly in visual compared to somatosensory cortex, possibly reflecting differences in the capacity for experience-dependent plasticity in these brain regions...
  20. ncbi Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis
    G V Putcha
    Departments of Neurology and Molecular Biology and Pharmacology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuron 29:615-28. 2001
    ....
  21. ncbi Long-term fate and distribution of newborn cells in the adult mouse olfactory bulb: Influences of olfactory deprivation
    N Mandairon
    Laboratoire de Neurosciences et Systèmes Sensoriels, CNRS UMR 5020, Universite Claude Bernard Lyon 1, 50 avenue Tony Garnier, 6936, Lyon Cedex 07, France
    Neuroscience 141:443-51. 2006
    ..In addition, our data suggest a functional heterogeneity of neurogenesis within the granular layer...
  22. ncbi Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo
    Paola Arlotta
    MGH HMS Center for Nervous System Repair, Departments of Neurosurgery and Neurology, Program in Neuroscience and Harvard Stem Cell Institute, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuron 45:207-21. 2005
    ....
  23. pmc Isoflurane-induced neuroapoptosis in the neonatal rhesus macaque brain
    Ansgar M Brambrink
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Anesthesiology 112:834-41. 2010
    ..Therefore, we exposed postnatal day 6 (P6) rhesus macaques to a surgical plane of isoflurane anesthesia for 5 h, and studied the brains 3 h later for histopathologic changes...
  24. ncbi c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice
    K Burau
    Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, INF 307, D 69120 Heidelberg, Germany
    Eur J Neurosci 20:353-62. 2004
    ..ChAT) and the vesicular acetylcholine transporter (VAChT) in stellate ganglia of homozygous newborn animals. The number of neurons positive for tyrosine hydroxylase (TH) mRNA, the rate-limiting enzyme of noradrenaline ..
  25. pmc Neonatal exposure to bisphenol a alters reproductive parameters and gonadotropin releasing hormone signaling in female rats
    Marina Fernandez
    Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Environ Health Perspect 117:757-62. 2009
    ..Several reports have revealed potent in vivo effects, because BPA acts as an estrogen agonist and/or antagonist and as an androgen and thyroid hormone antagonist...
  26. pmc The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
    O F Bueno
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    EMBO J 19:6341-50. 2000
    ..The results of the present study indicate that the MEK1-ERK1/2 signaling pathway stimulates a physiologic hypertrophy response associated with augmented cardiac function and partial resistance to apoptotsis...
  27. pmc The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia
    Kuei Y Tseng
    Department of Cellular and Molecular Pharmacology, RFUMS The Chicago Medical School, North Chicago, IL 60064, USA
    Behav Brain Res 204:295-305. 2009
    ....
  28. pmc Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase
    S F Kash
    Department of Medicine, School of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 94:14060-5. 1997
    ....
  29. ncbi Brain injury and neurofunctional deficit in neonatal mice with hypoxic-ischemic encephalopathy
    Vadim S Ten
    Department of Pediatrics, Columbia University, 3959 Broadway, BHS 12, Room 115, New York, NY 10032, USA
    Behav Brain Res 145:209-19. 2003
    ....
  30. ncbi Protection of neonatal mice from lethal enterovirus 71 infection by maternal immunization with attenuated Salmonella enterica serovar Typhimurium expressing VP1 of enterovirus 71
    Cheng Hsun Chiu
    Department of Pediatrics, Chang Gung Children s Hospital, Chang Gung University College of Medicine, Kweishan, Taoyuan 333, Taiwan
    Microbes Infect 8:1671-8. 2006
    ..Our data indicated that Salmonella-based VP1 subunit vaccines are a promising vaccine strategy in the prevention of EV71 infection...
  31. ncbi Perlecan is essential for cartilage and cephalic development
    E Arikawa-Hirasawa
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 23:354-8. 1999
    ..Our findings suggest that these molecules affect similar signalling pathways...
  32. ncbi Manipulation of antioxidant pathways in neonatal murine brain
    R Ann Sheldon
    Department of Neurology, University of California San Francisco, San Francisco, California 94143
    Pediatr Res 56:656-62. 2004
    ..008). These findings support the hypothesis that the immature brain has limited GPX activity and is more susceptible to oxidative damage and may explain the paradoxical effect seen in ischemic neonatal brain when SOD1 is overexpressed...
  33. pmc Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells
    Helene C Dujardin
    Unité du Développement des Lymphocytes, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1961, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 101:14473-8. 2004
    ..This study demonstrates that the peripheral immune system of newborn mice is endowed of a remarkable regulatory potential, which develops considerably in the absence of thymic supply...
  34. ncbi Notch signaling contributes to the expression of cardiac markers in human circulating progenitor cells
    Masamichi Koyanagi
    Department of Molecular Cardiology, Internal Medicine III, University of Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Circ Res 101:1139-45. 2007
    ..Gamma-secretase-dependent Notch activation is required for cardiac gene expression in human cells and induces the expression of noncanonical Wnt proteins, which may act in a paracrine manner to further amplify cardiac differentiation...
  35. ncbi Null mutation in the desmin gene gives rise to a cardiomyopathy
    L Thornell
    Department of Anatomy, Umea University, Umea, Sweden
    J Mol Cell Cardiol 29:2107-24. 1997
    ..Thus, the intermediate filaments are required to maintain the basic integrity of cardiomyocytes and especially the link between the intermediate filaments and the sarcolemma appear more important than previously realized...
  36. pmc Developmental regulation of spontaneous activity in the Mammalian cochlea
    Nicolas X Tritsch
    The Solomon H Snyder Department of Neuroscience and Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 30:1539-50. 2010
    ..These results suggest that supporting cells in the cochlea provide the primary excitatory stimulus responsible for initiating bursts of action potentials in auditory nerve fibers before the onset of hearing...
  37. pmc alpha3beta1 Integrin is required for normal development of the epidermal basement membrane
    C M DiPersio
    Center for Cancer Research, and Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Cell Biol 137:729-42. 1997
    ..Our findings support a novel role for alpha3beta1 in establishment and/or maintenance of basement membrane integrity, while alpha6beta4 is required for stable adhesion of the epidermis to the basement membrane through hemidesmosomes...
  38. ncbi Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults
    David F Wozniak
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 17:403-14. 2004
    ..We hypothesize that neuroapoptotic damage in homologous regions of human brain underlies cognitive deficits in FAS and the human brain of FAS victims has a similar capacity to effect functional recovery...
  39. ncbi Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry
    Timothy J M Moss
    School of Women s and Infants Health and Centre for Child Health Research, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 165:805-11. 2002
    ....
  40. ncbi p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate
    Elizabeth J Coulson
    Queensland Brain Institute and School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Neurosci 28:315-24. 2008
    ..Our results demonstrate a novel mode of activation of GIRK channels, representing an early step in the p75(NTR)-mediated cell death pathway and suggesting a function for these channels during nervous system development...
  41. ncbi Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity
    Wenying Jin
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Neurosci 26:2380-90. 2006
    ..Together, our findings indicate that the lipid binding of the PICK1 BAR domain is important for its synaptic targeting, AMPA receptor trafficking, and synaptic plasticity...
  42. ncbi Protein-tyrosine phosphatase 1B-deficient myocytes show increased insulin sensitivity and protection against tumor necrosis factor-alpha-induced insulin resistance
    Iria Nieto-Vazquez
    Department of Biochemistry, Faculty of Pharmacy, Universidad Complutense, 28040 Madrid, Spain
    Diabetes 56:404-13. 2007
    ..However, mice lacking PTP1B maintained a rapid clearance of glucose and insulin sensitivity and displayed normal muscle insulin signaling regardless the presence of TNF-alpha...
  43. ncbi Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia
    Jihong Xu
    Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Neurosci Res 81:403-11. 2005
    ..Collectively, these results raise the possibility that PPAR-alpha and RXR agonists might have benefit as a therapy in MS, where activated microglia are believed to contribute to disease pathology...
  44. ncbi Early postnatal development of spontaneous and acoustically evoked discharge activity of principal cells of the medial nucleus of the trapezoid body: an in vivo study in mice
    Mandy Sonntag
    Faculty of Bioscience, Pharmacy, and Psychology, University of Leipzig, Leipzig, Germany
    J Neurosci 29:9510-20. 2009
    ..These data emphasize that models of signal transmission at the calyx of Held based on in vitro data have to take developmental changes in firing rates and response latencies up to the fourth postnatal week into account...
  45. ncbi Developmental changes in spontaneous smooth muscle activity in the neonatal rat urinary bladder
    Eniko A Szell
    Department of Pharmacology, University of Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Regul Integr Comp Physiol 285:R809-16. 2003
    ..The emergence of faster activity in bladders from older animals may reflect the development of multiple pacemaker sites, which would reduce coordination within the bladder wall and improve storage function in the mature bladder...
  46. ncbi Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells
    T Self
    MRC Institute of Hearing Research, University Park, Nottingham NG7 2RD, UK
    Development 125:557-66. 1998
    ..These findings suggest that myosin VIIA is required for normal stereocilia bundle organisation and has a role in the function of cochlear hair cells...
  47. ncbi NT-3, like NGF, is required for survival of sympathetic neurons, but not their precursors
    N Francis
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, 44106, USA
    Dev Biol 210:411-27. 1999
    ..5 but does alter axon outgrowth and decrease salivary gland innervation. Taken together these results suggest that neurotrophin-3 is required for survival of some sympathetic neurons that also require nerve growth factor...
  48. ncbi Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts
    Wei Hsueh
    Department of Pathology, Children s Memorial Hospital, Northwestern University Medical School, 2300 Children s Plaza, Chicago, IL 60614, USA
    Pediatr Dev Pathol 6:6-23. 2003
    ..The former maintains intestinal perfusion and the integrity of the mucosal barrier, and the latter keep virulent bacteria in check. The development of tissue injury depends on the balance between injurious and protective mechanisms...
  49. pmc Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival
    D Joshua Cameron
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Int J Biol Sci 3:111-9. 2007
    ..These results implicate the importance of these long chain fatty acids in skin barrier development. Furthermore, we suggest that Elovl4 is likely involved in the elongation of C26 and longer fatty acids...
  50. ncbi Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis
    Fabian Docagne
    Universite de Caen, CNRS UMR 6551, Bd H Becquerel, B P 5229, 14074 Caen Cedex, France
    Mol Cell Neurosci 21:634-44. 2002
    ..Overall, this study underlines the critical role of the t-PA/PAI-1 axis in the regulation of glutamatergic neurotransmission...
  51. ncbi A common mechanism of action for three mood-stabilizing drugs
    Robin S B Williams
    Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK
    Nature 417:292-5. 2002
    ..Inhibitors of prolyl oligopeptidase reverse the effects of all three drugs on sensory neuron growth cone area and collapse. These results suggest a molecular basis for both bipolar affective disorder and its treatment...
  52. ncbi Tissue engineering of a differentiated cardiac muscle construct
    W H Zimmermann
    Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Circ Res 90:223-30. 2002
    ..The data indicate that EHTs represent highly differentiated cardiac tissue constructs, making EHTs a promising material for in vitro studies of cardiac function and tissue replacement therapy...
  53. ncbi Glial responses, neuron death and lesion resolution after intracerebral hemorrhage in young vs. aged rats
    Jason K Wasserman
    Toronto Western Research Institute, University Health Network, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, Canada
    Eur J Neurosci 28:1316-28. 2008
    ..These findings have important implications for efforts to reduce secondary injury after ICH and to develop anti-inflammatory therapies to treat ICH in aged humans...
  54. ncbi Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice
    E Hummler
    Institut de Pharmacologie et de Toxicologie de l Université, Lausanne, Switzerland
    Nat Genet 12:325-8. 1996
    ..Alpha-ENaC(-/-) neonates developed respiratory distress and died within 40 h of birth from failure to clear their lungs of liquid. This study shows that ENaC plays a critical role in the adaptation of the newborn lung to air breathing...
  55. pmc The neural substrates of infant sleep in rats
    Karl A E Karlsson
    Program in Behavioral and Cognitive Neuroscience, Department of Psychology, University of Iowa, Iowa City, USA
    PLoS Biol 3:e143. 2005
    ....
  56. pmc GABA regulates excitatory synapse formation in the neocortex via NMDA receptor activation
    Doris D Wang
    Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 28:5547-58. 2008
    ..Our study identifies an essential role for GABA in the synaptic integration of newborn cortical neurons and suggests an activity-dependent mechanism for achieving the balance between excitation and inhibition in the developing cortex...
  57. ncbi The role of autophagy during the early neonatal starvation period
    Akiko Kuma
    Time s Arrow and Biosignaling, PRESTO, Japan Science and Technology Agency, Kawaguchi 332 0012, Japan
    Nature 432:1032-6. 2004
    ..These results suggest that the production of amino acids by autophagic degradation of 'self' proteins, which allows for the maintenance of energy homeostasis, is important for survival during neonatal starvation...
  58. ncbi Infant vocalization, adult aggression, and fear behavior of an oxytocin null mutant mouse
    J T Winslow
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Horm Behav 37:145-55. 2000
    ..We conclude that the absence of exposure to OT during development was associated with abnormalities in the development of emotional behavior...
  59. ncbi An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons
    Fan Jia
    CV Starr Laboratory for Molecular Neuropharmacology, Department of Anesthesiology, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Neurophysiol 94:4491-501. 2005
    ..In view of the critical role of thalamic neurons in the generation of oscillatory activity associated with sleep, these receptors may represent a principal site of action for the novel hypnotic agent gaboxadol...
  60. ncbi Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death
    T Braun
    Department of Toxicology, University of Hamburg Medical School, Germany
    Cell 71:369-82. 1992
    ....
  61. ncbi Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma
    Siddharama Pawate
    Department of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci Res 77:540-51. 2004
    ....
  62. pmc Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells
    M C Ryan
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Cell Biol 145:1309-23. 1999
    ..These results indicate that laminin 5 has an important role in regulating tissue organization, gene expression, and survival of epithelium...
  63. pmc Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN-gamma in experimental biliary atresia
    Pranavkumar Shivakumar
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    J Clin Invest 114:322-9. 2004
    ..Thus, IFN-gamma-driven obstruction of bile ducts is a key pathogenic mechanism of disease and may constitute a therapeutic target to block disease progression in patients with biliary atresia...
  64. ncbi A novel functional neuron group for respiratory rhythm generation in the ventral medulla
    Hiroshi Onimaru
    Showa University School of Medicine, Shinagawa ku, Tokyo 142 8555, Japan
    J Neurosci 23:1478-86. 2003
    ..Our findings suggest that the pFRG comprises a neuronal population that is involved in the primary respiratory rhythm generation in the rostrocaudally extending respiratory neuron network of the medulla...
  65. pmc Age at first viral infection determines the pattern of T cell-mediated disease during reinfection in adulthood
    Fiona J Culley
    Department of Respiratory Medicine, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology, and Medicine, London W2 1PG, United Kingdom
    J Exp Med 196:1381-6. 2002
    ..Thus, simply delaying RSV infection beyond infancy might reduce subsequent respiratory morbidity in later childhood...
  66. pmc Neonatal bisphenol-a exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons
    Heather B Adewale
    Department of Biology, North Carolina State University, Raleigh, North Carolina, USA
    Biol Reprod 81:690-9. 2009
    ..Our data suggest that BPA disrupts ovarian development but not the ability of GnRH neurons to respond to steroid-positive feedback...
  67. ncbi Differential role of N-type calcium channel splice isoforms in pain
    Christophe Altier
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    J Neurosci 27:6363-73. 2007
    ..In contrast, both N-type channel isoforms (e37a- and e37b-containing) contribute to tactile neuropathic allodynia. Hence, exon 37a acts as a molecular switch that tailors the channels toward specific roles in pain...
  68. ncbi Selective adaptation in networks of cortical neurons
    Danny Eytan
    Faculties of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Neurosci 23:9349-56. 2003
    ..The observation that selective adaptation arises naturally in a network of cortical neurons developing ex vivo indicates that this is an inherent feature of spontaneously organizing cortical networks...
  69. ncbi A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling
    Hao Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Nat Genet 36:1111-6. 2004
    ..Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated...
  70. ncbi Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia
    Yoon Seong Kim
    Burke Medical Research Institute, Weill Medical College and Graduate School of Medical Sciences of Cornell University, White Plains, New York 10605, USA
    J Neurosci 25:3701-11. 2005
    ..Therefore, the release of MMP-3 from apoptotic neurons may play a major role in degenerative human brain disorders, such as Parkinson's disease...
  71. pmc Local sharing as a predominant determinant of synaptic matrix molecular dynamics
    Shlomo Tsuriel
    The Rappaport Family Institute for Research in the Medical Sciences, Technion Faculty of Medicine, Haifa, Israel
    PLoS Biol 4:e271. 2006
    ....
  72. ncbi Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin
    Sandra Thyssen
    Lawson Health Research Institute, St Joseph s Health Care, London, Ontario, Canada
    Endocrinology 147:2346-56. 2006
    ..The target cells of GLP-1 probably include immature beta-cells that coexpress proglucagon...
  73. ncbi Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2
    Jeremy A Cholfin
    Medical Scientist Training Program, University of California, San Francisco, San Francisco, California 94143 2611, USA
    J Comp Neurol 509:144-55. 2008
    ..We have integrated our results to propose a model for how fibroblast growth factors regulate FC patterning through regulation of regional transcription factor expression within the FC anlage...
  74. pmc Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin
    Charles Keller
    Division of Pediatric Hematology Oncology, Department of Pediatrics, University of Utah, Salt Lake City, Utah 84112, USA
    Genes Dev 18:2608-13. 2004
    ....
  75. ncbi Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: evidence for uncoupled regulation of mPGES-1 and COX-2
    Antonio Carlos Pinheiro de Oliveira
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    Glia 56:844-55. 2008
    ....
  76. ncbi A twist code determines the onset of osteoblast differentiation
    Peter Bialek
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Cell 6:423-35. 2004
    ..In vivo mutagenesis confirms the antiosteogenic function of the Twist box. Thus, relief of inhibition by Twist proteins is a mandatory event precluding osteoblast differentiation...
  77. ncbi Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats
    X Ke
    Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah 84158, USA
    Physiol Genomics 25:16-28. 2006
    ..Despite these differences, caloric, fat, and protein content were similar in breast milk from Con and IUGR dams. We conclude that IUGR results in postnatal changes in cerebral chromatin structure and that these changes are sex specific...
  78. ncbi Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex
    R H Baloh
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 21:1291-302. 1998
    ....
  79. ncbi Targeted ablation of Arnt in mouse epidermis results in profound defects in desquamation and epidermal barrier function
    Songmei Geng
    Department of Dermatology, Columbia University, New York, NY, USA
    J Cell Sci 119:4901-12. 2006
    ..The functional defects in Arnt-null mouse epidermis underscore the crucial role of Arnt in the maintenance of epidermal homeostasis, especially during the perinatal transition to the ex utero environment...
  80. ncbi Retinal progenitor cell xenografts to the pig retina: morphologic integration and cytochemical differentiation
    Karin Warfvinge
    Department of Ophthalmology, Lund University Hospital, Lund, Sweden
    Arch Ophthalmol 123:1385-93. 2005
    ..To investigate the survival, integration, and differentiation of mouse retinal progenitor cells after transplantation to the subretinal space of adult pigs...
  81. pmc Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
    Peter D Gluckman
    Liggins Institute, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand
    Proc Natl Acad Sci U S A 104:12796-800. 2007
    ....
  82. pmc Activation of NF-kappa B is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes
    N H Purcell
    Ben May Institute for Cancer Research and the Committee on Cancer Biology, University of Chicago, 5841 South Maryland Avenue, MC6027, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 98:6668-73. 2001
    ..These findings suggest that NF-kappaB plays a critical role in the hypertrophic growth of cardiomyocytes and may serve as a potential target for the intervention of heart disease...
  83. ncbi Minocycline decreases in vitro microglial motility, beta1-integrin, and Kv1.3 channel expression
    Nancy Nutile-McMenemy
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, USA
    J Neurochem 103:2035-46. 2007
    ....
  84. ncbi Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors
    Christopher L Antos
    Department of Molecular Biology, The University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas 75390 9148, USA
    J Biol Chem 278:28930-7. 2003
    ..HDAC inhibitors are currently being tested in clinical trials as anti-cancer agents. Our results suggest that these inhibitors may also hold promising clinical value as therapeutics for cardiac hypertrophy and heart failure...
  85. pmc A divergent canonical WNT-signaling pathway regulates microtubule dynamics: dishevelled signals locally to stabilize microtubules
    Lorenza Ciani
    Department of Biological Sciences, Imperial College London, London SW7 2AZ, England, UK
    J Cell Biol 164:243-53. 2004
    ..Our data indicate a bifurcation in the so-called canonical WNT-signaling pathway to regulate microtubule stability...
  86. pmc Electroporation and RNA interference in the rodent retina in vivo and in vitro
    Takahiko Matsuda
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:16-22. 2004
    ..Plasmid DNA was also efficiently transfected into retinal explants in vitro by high-voltage pulses...
  87. ncbi Early motor activity drives spindle bursts in the developing somatosensory cortex
    Rustem Khazipov
    INMED, INSERM U29, Avenue de Luminy, B P 13, 13273 Marseille, France
    Nature 432:758-61. 2004
    ..We suggest that the interaction between movement-triggered sensory feedback signals and self-organized spindle oscillations shapes the formation of cortical connections required for sensorimotor coordination...
  88. ncbi Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): suppression of receptor-evoked calcium signaling and control of release function
    Anja Hoffmann
    Department of Cellular Neurosciences, Max Delbruck Center for Molecular Medicine, D 13092 Berlin, Germany
    J Neurosci 23:4410-9. 2003
    ..Elevation of basal [Ca 2+]i could thus prove a central element in the regulation of executive functions in activated microglia...
  89. ncbi Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis
    Karin List
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland, MD 20892, USA
    Oncogene 21:3765-79. 2002
    ..This study demonstrates that Matriptase/MT-SP1 has pleiotropic functions in the development of the epidermis, hair follicles, and cellular immune system...
  90. pmc A single intravenous injection of adeno-associated virus serotype-9 leads to whole body skeletal muscle transduction in dogs
    Yongping Yue
    Department of Molecular Microbiology and Immunology, School of Medicine, The University of Missouri, Columbia, Missouri 65212, USA
    Mol Ther 16:1944-52. 2008
    ..In particular, cardiac muscle was barely transduced in dogs. Many muscular dystrophy patients can be identified by neonatal screening. The technology described here may lead to an effective early intervention in these patients...
  91. ncbi Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long-Evans rats
    Mikhail Kalinichev
    Rollins Research Centre, Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Room 5074, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 73:131-40. 2002
    ..Therefore, experiencing maternal separation results in a long-lasting increase in anxiety-like behaviors that occurs in a sex-dependent manner...
  92. ncbi Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex
    Marta Nieto
    Department of Neurology, Harvard Medical School and Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Comp Neurol 479:168-80. 2004
    ..The patterns of expression of Cux genes suggest potential roles as determinants of the neuronal fate of the upper cortical layer neurons...
  93. ncbi Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions
    Zhihu Zhao
    Department of Development and Genetics, Evolution Biology Centre, Uppsala University, Norbyvagen 18A, SE 752 36 Uppsala, Sweden
    Nat Genet 38:1341-7. 2006
    ..These observations shed new light on development, cancer epigenetics and the evolution of imprinting...
  94. ncbi Physiological development of insulin secretion, calcium channels, and GLUT2 expression of pancreatic rat beta-cells
    Victor Navarro-Tableros
    Department of Biophysics, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Am J Physiol Endocrinol Metab 292:E1018-29. 2007
    ....
  95. pmc Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors
    Setsuko Sahara
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Neuron 63:48-62. 2009
    ....
  96. pmc Desmin is essential for the tensile strength and integrity of myofibrils but not for myogenic commitment, differentiation, and fusion of skeletal muscle
    Z Li
    Station Centrale de Microscopie Electronique, Institut Pasteur, Paris, France
    J Cell Biol 139:129-44. 1997
    ..The results presented here show that desmin is essential to maintain the structural integrity of highly solicited skeletal muscle...
  97. ncbi Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis
    Keiko Ohsawa
    Department of Neurochemistry, National Institute of Neuroscience, Kodaira, Tokyo 187 8502, Japan
    Glia 55:604-16. 2007
    ..These results indicate that P2X(4)R as well as P2Y(12)R is involved in ATP-induced microglial chemotaxis...
  98. ncbi Smooth-muscle contraction without smooth-muscle myosin
    I Morano
    Max Delbrück Center for Molecular Medicine MDC, Robert Rössle Strabe 10, D 13092 Berlin, Germany
    Nat Cell Biol 2:371-5. 2000
    ..We conclude that phase 1 becomes indispensable for survival and normal growth soon after birth, particularly for functions such as homeostasis and circulation...
  99. ncbi Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes
    Manuela Zaccolo
    Department of Biomedical Sciences and Venetian Institute for Molecular Medicine, University of Padua, Via Orus 2, 35129 Padua, Italy
    Science 295:1711-5. 2002
    ..Furthermore, we demonstrate that such gradients of cAMP specifically activate a subset of protein kinase A molecules anchored in proximity to the T tubule...
  100. ncbi Dlx5 regulates regional development of the branchial arches and sensory capsules
    M J Depew
    Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry and Programs in Neuroscience, Developmental Biology, Oral Biology and Biomedical Sciences, University of California at San Fran
    Development 126:3831-46. 1999
    ....
  101. ncbi Postnatal development of radial glia and the ventricular zone (VZ): a continuum of the neural stem cell compartment
    Anthony D Tramontin
    Department of Neurosurgery Research, University of California, San Francisco, CA 94143, USA
    Cereb Cortex 13:580-7. 2003
    ..We propose that a VZ 'compartment' is retained postnatally and that this niche may be essential for stem cell function...

Research Grants62

  1. The upper airway and the Sudden Infant Death Syndrome
    Donald Bartlett; Fiscal Year: 2012
    ..LCR)-apnea and swallowing in response to intralaryngeal water, milk or other fluids-is more prominent in newborn animals and human infants than in adults and, therefore, has long been suspected as a cause of some cases of SIDS...
  2. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2013
    ..to cross the placenta and concentrate in the fetus, and prenatal nicotine exposure impairs the ability of newborn animals to resuscitate from cardiorespiratory challenges...
  3. Children's Exposure to Flame Retardants: Effects on Thyroid Hormone Regulation
    Heather M Stapleton; Fiscal Year: 2012
    ..have found that PBDEs exert negative effects on thyroid hormone homeostasis, which is more pronounced in newborn animals relative to adults...
  4. Mitochondria, Superoxide &MnSOD in a fetal hypoxic cerebral palsy model
    Matthew Derrick; Fiscal Year: 2012
    ..clinically relevant model of acute placental insufficiency that results in a cerebral palsy phenotype in the newborn animals. Magnetic resonance imaging during the acute insult and the early reperfusion period predicts which animals ..
  5. Stratum Corneum Acidification in the Neonate
    Kenneth Feingold; Fiscal Year: 2007
    ..b) compromised SC integrity and cohesion, and c) decreased threshold for the development of inflammation in newborn animals with a neutral SC pH...
  6. Neuroplasticity and the carotid body
    Estelle Gauda; Fiscal Year: 2009
    ..during early postnatal development significantly depresses ventilatory responses to acute hypoxia in both newborn animals and human infants born prematurely...
  7. CEREBRAL ISCHEMIA AND FREE OXYGEN RADICALS
    Jeffrey Kirsch; Fiscal Year: 1991
    ..in the pathophysiology of global cerebral ischemia and hypoxia and to determine if the apparent ability of newborn animals to tolerate reduced cerebral oxygen availability is related to a free radical mechanism...
  8. Regulation of Akt and glucose transport by prolactin
    Steven Anderson; Fiscal Year: 2006
    Lactation is of great importance to survival of newborn animals. Prolactin plays a critical role in this process by regulating the differentiation of mammary epithelial cells into secretory epithelial cells...
  9. ADENO-ASSOCIATED VIRUS GENE TRANSFER INTO NEONATES
    Mark Sands; Fiscal Year: 1999
    ..whether AAV can be readministered, what the in vivo distribution is following intravenous administration to newborn animals or whether the levels of expression can impact on a disease...
  10. INDUCERS OF MATURATION OF RENAL AMINO ACID TRANSPORT
    Russell Chesney; Fiscal Year: 1980
    ..of different ages who have been treated with a high taurine diet, examine the differences between adult and newborn animals in terms of their differential response to dibutyryl cyclic AMP, develop assays for marker enzymes for kidney ..
  11. Renal and Hormonal Mechanisms of Perinatal Programming
    LORI WOODS; Fiscal Year: 2005
    ..Intrarenal RAS activity will be measured in fetal and newborn animals. Arterial pressure, renal function, and nephron number will be measured in chronically instrumented juvenile ..
  12. MOLECULAR PATHOGENESIS OF REOVIRUS INDUCED DISEASE
    Howard Weiner; Fiscal Year: 1980
    ..These serotypes, when injected into newborn animals, cause different diseases of the central nervous systems...
  13. NUTRITIONAL TAURINE--PREGNANCY AND OUTCOME
    John Sturman; Fiscal Year: 1993
    ..morphometric measures of brain cells for all three groups, both at weaning 8 weeks after birth and in newborn animals. This will include a laminar analysis of the number of neurons, astrocytes, oligodendrocytes and microglia in ..
  14. CHEMOKINE REGULATION IN PULMONARY OXYGEN INJURY
    CARL D ANGIO; Fiscal Year: 2001
    ..Adult and newborn AMs will be exposed to pulmonary lavage fluid from hyperoxia-exposed adult and newborn animals to assess independently possible host and cellular immaturities in the response.
  15. PRENATAL VIRAL INFECTION AND NEUROENDOCRINE DEVELOPMENT
    MAUREEN O GRADY; Fiscal Year: 1991
    ..Viral infection elevates glucocorticoid levels in adult and newborn animals. The proposed experiments have been designed to assess whether or not exposure to viral infection during the ..
  16. ANTIVIRAL ANTIBODIES AND CNS INFECTION WITH CMV
    William Britt; Fiscal Year: 2001
    ..b>Newborn animals, including transgenic mu chain knockout mice (antibody negative), will be infected, and the CNS infection ..
  17. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
    ....
  18. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  19. Calcium Homeostasis and Neonatal Brain Injury
    Christopher Turner; Fiscal Year: 2009
    ....
  20. Perinatal Infection and Memory
    STACI BILBO; Fiscal Year: 2006
    ..The duration of memory impairment will also be measured, and a number of memory paradigms will be tested. ..
  21. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  22. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  23. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  24. Early Life Infection, Neuroinflammation, and Memory
    Staci D Bilbo; Fiscal Year: 2010
    ....
  25. Mechanism and Molecular Recognition in Human Pyruvate Dehydrogenase Complex
    Mulchand Patel; Fiscal Year: 2008
    ..abstract_text> ..
  26. Sphingolipids in Ethanol-Induced Neuronal Apoptosis
    Mariko Saito; Fiscal Year: 2010
    ..These studies will reveal the functions of sphingolipids in ethanol-induced apoptosis in the developing brain, and will offer bases for future therapeutic strategies for FASD. ..
  27. Prenatal Virally Induced Brain Disorder in Mouse
    SEYYED FATEMI; Fiscal Year: 2009
    ..In addition, it is expected that the results will provide clues that will lead to fundamental advances in our knowledge of the pathogenesis of schizophrenia and, therefore, of how it can be prevented and treated. ..
  28. Varenicline and Smoking Cessation in Schizophrenia
    SEYYED HOSSEIN FATEMI; Fiscal Year: 2010
    ..Such outcomes will be significant, because they will offer a new treatment for smoking cessation in this vulnerable population. ..
  29. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    ..We feel these experiments will provide important specific insights into the regulation of neonatal intestinal growth and injury. ..
  30. Epo as a Rescue Agent for Perinatal Hypoxia-Ischemia
    Sandra Juul; Fiscal Year: 2004
    ....
  31. Aerosolized PGE1 in Neonatal Pulmonary Hypertension
    BEENA SOOD; Fiscal Year: 2005
    ..If effective, a proposal for using aerosolized PGE1 in neonatal PPHN as a multicenter study will be submitted to the NICHD Neonatal Network. ..
  32. REGULATION OF MAMMALIAN DIHYDROLIPOAMIDE DEHYDROGENASE
    Mulchand Patel; Fiscal Year: 2002
    ..abstract_text> ..
  33. DIET INDUCED HYPERINSULINEMIA AND BETA CELL FUNCTION
    Mulchand Patel; Fiscal Year: 2001
    ..This unique rat model has the potential for providing new and significant insight into the "fuel hypothesis" for altered insulin secretory response in response to diet and maternal influences on fetal pancreatic adaptations. ..
  34. Dynamic Molecular Mechanisms of Neurotransmitter Release
    FELIX SCHWEIZER; Fiscal Year: 2004
    ..By revealing novel mechanisms for the modulation of neurotransmitter release they may identify targets for therapeutic intervention in neurological diseases. ..
  35. Chemoreflex plasticity and BDNF
    David Katz; Fiscal Year: 2002
    ..Moreover, it is hoped that elucidating development of this system will, in turn, create a model of neurotrophin function applicable to the nervous system as a whole. ..
  36. Expression and function of PIGF in cardiomyocytes
    RONALD TORRY; Fiscal Year: 2003
    ..Collectively, these data may provide support for PIGF-mediated therapeutic approaches to facilitate coronary microvascular growth and/or reduce the cardiomyocyte loss associated with ischemic heart disease. ..
  37. Role of Apoptosis in Pemphigus
    Ning Li; Fiscal Year: 2008
    ..The work is likely to lead to a more comprehensive R01 project investigating the apoptotic pathways involved in pemphigus and its pathogenic role in pemphigus. ..
  38. ANESTHETIC ACTIONS AT GABA AND GLUTAMATE SYNAPSES
    M MacIver; Fiscal Year: 2004
    ..abstract_text> ..
  39. Prostanoids and hypoxic neonatal pulmonary hypertension
    CANDICE FIKE; Fiscal Year: 2009
    ..The goal of this project is to help us understand why infants develop pulmonary hypertension, determine what happens in the lung blood vessels during disease development, and develop treatments for this disease. ..
  40. MOLECULAR PATHOGENESIS OF FELINE SPINAL MUSCULAR ATROPHY
    JOHN FYFE; Fiscal Year: 2002
    ..Initial candidate genes will be those implicated in human SMA, but otherwise a comparative positional-candidate gene approach will be taken. ..
  41. Chromatin-based cellular memory in neural stem cells
    Daniel Lim; Fiscal Year: 2009
    ..Furthermore, our studies may lead to discoveries of how derangements in chromatin remodeling can lead to the development of brain tumors. ..
  42. NEONATAL ENCEPHALOPATHY TREATED BY MODERATE HYPOTHERMIA
    Dorothea Jenkins; Fiscal Year: 2001
    ..abstract_text> ..
  43. MOLECULAR NETWORKS THAT COORDINATE DIFFERENTIATION
    William Loomis; Fiscal Year: 2003
    ..Together these studies will help to establish a signal transduction pathway that can serve as a model for studies in other systems. ..
  44. Endothelial Transmigration Across the RPE Barrier
    Mary Elizabeth Hartnett; Fiscal Year: 2005
    ..Increased knowledge of the mechanisms that cause this destructive phenomenon may lead to future means to prevent CNV in the neurosensory retina, and thus, reduce vision loss in AMD. ..
  45. Development of neuromuscular junctions in children with cerebral palsy
    Robert Akins; Fiscal Year: 2008
    ..The PIs study these interactions in order to develop therapies and treatments that will improve and sustain the physical ability and health of patients with CP. [unreadable] [unreadable] [unreadable]..
  46. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  47. PEDIATRIC NEPHROLOGY TRAINING
    Michel Baum; Fiscal Year: 2005
    ..Fellows also attend seminars in basic science departments. The research mentor, as well as the program director, closely supervise trainees to ensure that the goals of the training program are achieved. ..
  48. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..This will lead to improved outcomes in adulthood. ..
  49. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005
    ..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..
  50. Brain Manganese Deposition in High Risk Neonates
    Judy Aschner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. Center for Fetal Gene Transfer for HLB Diseases
    Alice Tarantal; Fiscal Year: 2005
    ..abstract_text> ..
  52. Genetic risk factors for Sudden Cardiac Death
    Nona Sotoodehnia; Fiscal Year: 2007
    ....
  53. Enhancing Recovery after Neonatal Stroke
    John Barks; Fiscal Year: 2008
    ..Together these experiments will provide insights into the mechanisms that mediate and modulate functional recovery after neonatal stroke. [unreadable] [unreadable]..
  54. Ontogenetic Changes in Control of Rhythmicity in rabbits
    Mario Caba; Fiscal Year: 2008
    ..g. jet lag, shift work. Once characterized, we can use this information to control circadian rhythms in circumstances where it is disrupted. ..
  55. Leptin As A Novel Neurohormonal Anticonvulsant
    KWEE THIO; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  56. Hsp90/Client Protein Interactions in the Newborn Lung
    Judy Aschner; Fiscal Year: 2008
    ..These studies will improve understanding of the neonatal pulmonary hypertensive response to chronic hypoxia and are critical to the formulation of novel treatment strategies for infants with PH. ..
  57. 2007 CARTILAGE BIOLOGY & PATHOLOGY GORDON RESEARCH CONFERENCE
    Henry Kronenberg; Fiscal Year: 2007
    ..Special attention has been given to assure that the meeting takes full advantage of substantial representation of woman scientists as speakers and session chairs. ..
  58. REGULATION OF CAROTID BODY AFFERENT DEVELOPMENT
    David Katz; Fiscal Year: 2008
    ..Moreover, it is hoped that defining developmental mechanisms in this system will, in turn, create a model of growth factor function and regulation that is applicable to the nervous system as a whole. [unreadable] [unreadable]..