- Species-specific assessment of pain in laboratory animals
Karen L Stasiak
Department of Pathology, Veterinary Teaching Hospital, Colorado State University, Fort Collins, CO 80523 1682, USA
Contemp Top Lab Anim Sci 42:13-20. 2003
- Modifications to husbandry and housing conditions of laboratory rodents for improved well-being
Abigail L Smith
School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
ILAR J 46:140-7. 2005
..Also suggested are possible inexpensive and effective enrichment schemes for laboratory mice that might include reducing the cage floor space per mouse combined with providing nesting material...
- Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals
P J O'Brien
Safety Sciences Europe, Sandwich, Kent CT1 3NJ, UK
Lab Anim 40:153-71. 2006
..directly demonstrates that cardiac troponin I (cTnI) is a sensitive, specific, and persistent biomarker in laboratory animals. Histopathological and pathophysiological cardiac changes in dogs, rats and mice correlated with increased ..
- Establishing an appropriate period of acclimatization following transportation of laboratory animals
Jennifer A Obernier
Institute for Laboratory Animal Research, The National Academies, Washington, DC, USA
ILAR J 47:364-9. 2006
Stress associated with transportation has widespread effects on physiological systems in laboratory animals, including changes in the cardiovascular, endocrine, immune, central nervous, and reproductive systems...
- Guidelines for the design and statistical analysis of experiments using laboratory animals
Michael F W Festing
MRC Toxicology Unit, University of Leicester, UK
ILAR J 43:244-58. 2002
- Laboratory animals: the Renaissance rat
Nature 428:464-6. 2004
- Hearing in laboratory animals: strain differences and nonauditory effects of noise
Jeremy G Turner
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9629, USA
Comp Med 55:12-23. 2005
Hearing in laboratory animals is a topic that traditionally has been the domain of the auditory researcher...
- An inclined plane system with microcontroller to determine limb motor function of laboratory animals
Ming Wen Chang
Department of Electrical Engineering, National Cheng Kung University, Tainan 701, Taiwan
J Neurosci Methods 168:186-94. 2008
..It is found that the system is stable, accurate and easily used by investigators...
- Spatial and temporal patterns of expression of messenger RNA for insulin-like growth factors and their binding proteins in the placenta of man and laboratory animals
V K Han
Department of Paediatrics, Obstetrics and Gynaecology, Biochemistry and Anatomy, MRC Group in Fetal and Neonatal Health and Development, Lawson Research Institute, University of Western Ontario, London, Ontario, N6A 4V2, Canada
Placenta 21:289-305. 2000
..to date highlight the diversity in the expression of the IGF system among placentae of man and different laboratory animals, and even between closely related species...
- A comparative immunohistochemical study of pancreatic islets in laboratory animals (rats, dogs, minipigs, nonhuman primates)
Experimental Pathology, Novartis Pharma AG, Basel, Switzerland
Exp Toxicol Pathol 50:151-72. 1998
..and describe the patterns of distribution of pancreatic islets within the pancreas of four species of laboratory animals, including rats, dogs, minipigs and monkeys, and furthermore, to identify immunohistochemically various ..
- Defining, measuring, and interpreting stress in laboratory animals
Veterinary Medical Unit, Research 151 L, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, Washington 98108, USA
Contemp Top Lab Anim Sci 44:41-5. 2005
..However, stress is not inherently bad, and a stress response should not be assumed to indicate an experience of distress or pain. This paper examines ways in which research animal stress may be defined, measured, and interpreted...
- Virucidal efficacy of physico-chemical treatments against coronaviruses and parvoviruses of laboratory animals
Laboratory Animal Research Center, University of Tsukuba, Ibaraki, Japan
Jikken Dobutsu 37:341-5. 1988
..Ultraviolet radiation inactivated all viruses within 15 minutes. No significant differences in stability against physico-chemical treatments were seen between viruses in the same group...
- Incidence of allergy and allergy symptoms among workers exposed to laboratory animals
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Occup Environ Med 62:766-71. 2005
Few studies have described relations between exposure to laboratory animals and the incidence of laboratory animal allergy (LAA)...
- [Prevalence of occupational allergy to laboratory animals in two towns of northern and central Italy]
F Larese Filon
Dipartimento di Scienze di Medicina Pubblica, Universita degli Studi di Trieste, Via della Pieta 19, 34129 Trieste
Med Lav 93:87-94. 2002
..Laboratory animal allergy (LAA) is a well known occupational hazard for workers employed in biological and medical research institutes, but few Italian data on this disease exist...
- Review of growth plate closure compared with age at sexual maturity and lifespan in laboratory animals
Susan H Kilborn
Animal Care and Veterinary Service, Department of Medicine, University of Ottawa, Ontario, Canada K1H 8M5
Contemp Top Lab Anim Sci 41:21-6. 2002
..The rat was compared to other laboratory animals to assess differences in the duration of bone growth and its relationship to age at sexual maturity and ..
- An updated review of inhalation studies with cigarette smoke in laboratory animals
Christopher R E Coggins
Carson Watts Consulting, 1266 CarsonWatts Road, King, North Carolina 27021 7453, USA
Int J Toxicol 26:331-8. 2007
Until recently, the published literature on inhalation studies with laboratory animals and cigarette smoke consisted entirely of negative findings, as far as neoplastic disease is concerned...
- Factors affecting hearing in mice, rats, and other laboratory animals
James F Willott
University of South Florida, Tampa, FL, USA
J Am Assoc Lab Anim Sci 46:23-7. 2007
..An understanding of genetic and environmental influences on hearing and auditory behavior is important for those who provide, use, and care for laboratory animals.
- [Laboratory animals and official Mexican norms (NOM-062-ZOO-1999)]
Aline S de Aluja
Departamento de Patologia, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autonoma de Mexico, Circuito exterior s n, Ciudad Universitaria, CP 04510 Mexico, D F
Gac Med Mex 138:295-8. 2002
..Mexican norm Nom 0062-Zoo-1999 entitled Technical specifications for the production, care and use of laboratory animals. The history of animal experimentation is briefly resumed...
- [Microbiological standardization of laboratory animals]
Deutsches Krebsforschungszentrum, Zentrales Tierlabor
Berl Munch Tierarztl Wochenschr 112:201-10. 1999
An overview is given on various aspects of microbiological standardisation of laboratory animals. The paper focuses on small rodents because rats and mice are the most frequently used animal species...
- Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals
James M Antonini
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
J Occup Environ Hyg 3:194-203; quiz D45. 2006
- RandoMate: a program for the generation of random mating schemes for small laboratory animals
Armin O Schmitt
Institute for Animal Sciences, Humboldt Universitat zu Berlin, Berlin, Germany
Mamm Genome 20:321-5. 2009
..RandoMate is freely available at http://www2.hu-berlin.de/RandoMate ...
- Wallace P. Rowe lecture. Poxviruses of laboratory animals
John Curtin School of Medical Research, Australian National University
Lab Anim Sci 40:469-80. 1990
..The list could have been extended had I included chickens and swine as laboratory animals, for that would have meant that I would have spoken about the birdpox viruses and swinepox virus as well...
- Natural pathogens of laboratory animals and their effects on research
M D Connole
Department of Veterinary Pathology and Anatomy, School of Veterinary Science, The University of Queensland, Brisbane, Australia
Med Mycol 38:59-65. 2000
The natural fungal pathogens of laboratory animals such as rabbits and guinea pigs are mainly dermatophyte species, most commonly Trichophyton mentagrophytes and also, less frequently Microsporum gypseum and M. canis...
- Enrichment strategies for laboratory animals from the viewpoint of clinical veterinary behavioral medicine: emphasis on cats on dogs
Karen L Overall
Center for Neurobiology and Behavior Psychiatry Department, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
ILAR J 46:202-15. 2005
Behavioral wellness has become a recent focus for the care of laboratory animals, farm and zoo animals, and pets. Behavioral enrichment issues for these groups are more similar than dissimilar, and each group can learn from the other...
- Primary and secondary allergies to laboratory animals
Leslie E Goodno
Department of Epidemiology, CB 7435 McGavran Greenberg Hall, UNC School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
J Occup Environ Med 44:1143-52. 2002
Although laboratory animal allergy (LAA) is a significant occupational hazard among workers exposed to laboratory animals, few studies have evaluated long-term risks to workers who remain in the workplace...
- Potential for unintended consequences of environmental enrichment for laboratory animals and research results
AAALAC International, Hilo, HI, USA
ILAR J 46:129-39. 2005
- Immunogenicity of biopharmaceuticals in laboratory animals
Toxicology Division, Lilly Research Laboratories, Eli Lilly and Company, 2001 W Main Street, GL45, Greenfield, IN 46140, USA
Toxicology 158:71-4. 2001
..In addition, the characterization of the immunogenicity of biotechnology molecules provides a practical basis for determining the significance of antibody formation in preclinical safety studies...
- Recognizing and assessing pain, suffering and distress in laboratory animals: a survey of current practice in the UK with recommendations
Research Animals Department, RSPCA, Wilberforce Way, Southwater, West Sussex, RH13 9RS, UK
Lab Anim 36:378-95. 2002
..org.uk/pain/(Hawkins 2002). The present paper and the full report, including its recommendations, are intended to provide a source of information, discussion topics and ideas for all establishments that need to monitor animal well-being...
- Hearing ranges of laboratory animals
Henry E Heffner
Department of Psychology, University of Toledo, Toledo, OH, USA
J Am Assoc Lab Anim Sci 46:20-2. 2007
..As a result, a sound that is easily audible to one species may be less audible, or even inaudible, to another. The purpose of this review is to describe the variation in the hearing ranges of common laboratory animals.
- Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: old and new
Stephen S Hecht
The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street, SE, Minneapolis, MN 55455, USA
Carcinogenesis 26:1488-92. 2005
..This commentary attempts to put the new results in perspective with the existing literature on cigarette smoke inhalation studies in animals and discusses strengths, limitations and possible applications of available models...
- Evaluation and applications of radiotelemetry in small laboratory animals
Department of Safety and Environmental Affairs, Free University, DVM, 1081 BT Amsterdam, The Netherlands
Physiol Genomics 13:197-205. 2003
Radiotelemetry is the "state of the art" for monitoring physiological functions in awake and freely moving laboratory animals, while minimizing stress artifacts...
- Phytochemical screening and effect of aqueous extract of Ficus sycomorus L. (Moraceae) stem bark on muscular activity in laboratory animals
U K Sandabe
Department of Veterinary Physiology and Pharmacology, University of Maiduguri, P M B 1069, Maiduguri, Nigeria
J Ethnopharmacol 104:283-5. 2006
..It was concluded that the extract has inhibitory effect on both smooth and skeletal muscles contractions and contains important constituents for pharmacological activities...
- Association of Toll-like receptor 4 alleles with symptoms and sensitization to laboratory animals
Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 122:896-902.e4. 2008
Researchers and technicians working with laboratory animals (LAs) are exposed to animal allergen and endotoxin, which can interact to potentiate or inhibit symptoms or allergic responses...
- Guidance on the transport of laboratory animals
Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
Lab Anim 39:1-39. 2005
- Reference data for the principal physiological indicators in three species of laboratory animals
C L Alemán
Departamento de Toxicologia, Centro de Productos Naturales, Centro Nacional de Investigaciones Cientificas, La Habana, Cuba
Lab Anim 34:379-85. 2000
This paper contains the reference data for the main physiological indicators of three species of laboratory animals: mice, rabbits and dogs...
- An event-driven motion correction method for neurological PET studies of awake laboratory animals
Victor W Zhou
School of Physics, University of Sydney, NSW 2006, Sydney, Australia
Mol Imaging Biol 10:315-24. 2008
The purpose of the study is to investigate the feasibility of an event driven motion correction method for neurological microPET imaging of small laboratory animals in the fully awake state.
- Natural history of sensitization, symptoms and occupational diseases in apprentices exposed to laboratory animals
Dept of Chest Medicine, , Montreal, Canada
Eur Respir J 17:904-8. 2001
..and asthma (OA); and assesses the predictive value of skin testing and RC symptoms in apprentices exposed to laboratory animals, in a 3-4-yr programme...
- The use of radiotelemetry in small laboratory animals: recent advances
Department of Safety and Environmental Affairs, Free University, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
Contemp Top Lab Anim Sci 40:8-16. 2001
..provides an alternative means of obtaining physiological measurements from awake and freely moving laboratory animals, without introducing stress artifacts...
- Pathology and pathophysiology of drug-induced arterial injury in laboratory animals and its implications on the evaluation of novel chemical entities for human clinical trials
Department of Safety Assessment, SmithKline Beechman Pharmaceuticals, King of Prussia, PA 19403, USA
Pharmacol Toxicol 89:158-70. 2001
In toxicology studies, drug-induced arterial injury in laboratory animals continues to be a pressing issue of concern, particularly to those engaged in the discovery and development of novel therapies intended for human use...
- Investigating the dopaminergic synapse in vivo. II. Molecular imaging studies in small laboratory animals
Clinic of Nuclear Medicine, University Hospital Dusseldorf, Germany
Rev Neurosci 18:473-504. 2007
..Therefore, small laboratory animals such as rats and mice have become invaluable models for a variety of human disorders...
- Guidelines for the veterinary care of laboratory animals: report of the FELASA/ECLAM/ESLAV Joint Working Group on Veterinary Care
Hanna Marja Voipio
Laboratory Animal Centre, PO Box 5000, FIN 90014 University of Oulu, Finland
Lab Anim 42:1-11. 2008
..Managerial aspects, including occupational health and safety, are also areas where the veterinarian's input can assist in the successful implementation of the programme...
- Incidence and host determinants of probable occupational asthma in apprentices exposed to laboratory animals
Department of Chest Medicine, Hôpital du Sacré Coeur, Montreal, Quebec, Canada
Am J Respir Crit Care Med 163:899-904. 2001
..43 to 0.78). It is concluded that apprentices in animal health show a high incidence of probable OA, and that preexposure airway caliber and responsiveness as well as sensitization to pets are associated with an increased risk...
- Mandatory " enriched" housing of laboratory animals: the need for evidence-based evaluation
Ann C Benefiel
Beckman Institute, University of Illinois, Urbana Campaign, IL, USA
ILAR J 46:95-105. 2005
Environmental enrichment for laboratory animals has come to be viewed as a potential method for improving animal well-being in addition to its original sense as a paradigm for learning how experience molds the brain...
- A survey of rodent-borne pathogens carried by wild-caught Norway rats: a potential threat to laboratory rodent colonies
Judith D Easterbrook
The W Harry Feinstone Department of Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Lab Anim 42:92-8. 2008
..8%), were identified in wild-caught rats. The risk of pathogen transmission from wild-caught rats to laboratory colonies needs to be mitigated by minimizing exposures rather than assuming wild animals represent a minimal hazard...
- Science-based assessment of animal welfare: laboratory animals
Division of Laboratory Animal Science, Utrecht University, P O Box 80 166, 3508 TD Utrecht, the Netherlands Karolinska Institute, 17177 Stockholm, Sweden
Rev Sci Tech 24:503-13. 2005
..In this paper, attention is paid to the assessment of welfare, environmental factors affecting welfare, legislative requirements and future trends such as the production and use of genetically modified animals...
- Genetically modified laboratory animals--what welfare problems do they face?
Center for Bioethics and Risk Assessment, Department of Molecular Biology, University of Aarhus, Denmark
J Appl Anim Welf Sci 6:319-38. 2003
..In this article, we also consider suffering that may be involved in the process of generating GM animals. Finally, we discuss the role of GM animals in attempts to reduce, replace, and refine the use of animals in research...
- Host determinants for the development of allergy in apprentices exposed to laboratory animals
Dept of Chest Medicine, Hôpital du Sacré Coeur, Montreal, Canada
Eur Respir J 19:96-103. 2002
..sensitization and diseases differ between atopic and nonatopic subjects starting a career with exposure to laboratory animals (LA)...
- Frequency of allergic rhinitis to laboratory animals in university employees as confirmed by chamber challenges
Department of Otorhinolaryngology, Kuopio University Hospital, Kuopio, Finland
Allergy 59:295-301. 2004
..Occupational risk for laboratory animal allergy (LAA) is well known, but prevention is often insufficient and new cases keep appearing...
- Experimental infection of laboratory animals and sheep with Gongylonema pulchrum in Japan
School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
J Vet Med Sci 65:921-5. 2003
..No distinct morphological differences were observed in the worms from rabbits and sheep. These results indicate that rabbits are very suitable experimental definitive hosts for G. pulchrum...
- A fully implantable stimulator for use in small laboratory animals
Rodney E Millard
Department of Otolaryngology, University of Melbourne, East Melbourne, Victoria 3002, Australia
J Neurosci Methods 166:168-77. 2007
..which are delivered to a bipolar electrode array for chronic stimulation of neural tissue in free-running laboratory animals such as rats and mice. The system is magnetically coupled and contains no batteries or external leadwires...
- Interspecies transmission of Enterozytozoon bieneusi supported by observations in laboratory animals and phylogeny
Medical Microbiology Section, Bernhard Nocht Insitute for Tropical Medicine, Bernhard Nocht Str 74, 20359 Hamburg, Germany
Med Microbiol Immunol 194:207-9. 2005
..Zoonotic potential of E. bieneusi is thus supported on a phylogenetic basis...
- Measuring blood pressure in small laboratory animals
Department of Safety and Environmental Affairs DVM, Free University, Amsterdam, The Netherlands
Methods Mol Med 108:51-62. 2005
..This chapter describes the surgical aspects of the radiotelemetry techniques currently used to monitor and measure blood pressure in awake animals...
- Nasal lavage fluid examination and rhinomanometry in the diagnostics of occupational airway allergy to laboratory animals
Department of Occupational Diseases, Nofer Institute of Occupational Medicine, Lodz, Poland
Int J Occup Med Environ Health 16:125-32. 2003
- The use of lignocaine-prilocaine local anaesthetic cream for pain-free venepuncture in laboratory animals
P A Flecknell
Comparative Biology Centre, Medical School, Newcastle upon Tyne, UK
Lab Anim 24:142-6. 1990
..of topical application of a eutectic mixture of local anaesthetics (EMLA cream) in a number of species of laboratory animals. Application of EMLA cream enabled percutaneous insertion of catheters into the cephalic vein in dogs and ..
- Have the prevalence and incidence of occupational asthma and rhinitis because of laboratory animals declined in the last 25 years?
Occupational Allergology, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy
Allergy 63:834-41. 2008
..Data for time trends in the prevalence of occupational asthma (OA) and rhinitis (OR) are not known...
- A novel type of implantable and programmable infusion pump for small laboratory animals
Department of Physiology, Gifu University Graduate School of Medicine, Gifu, Japan
J Pharmacol Toxicol Methods 59:7-12. 2009
The iPRECIO (Primetech Corporation, Tokyo, Japan) is a new form of pump for infusing small laboratory animals. The key features of the iPRECIO are that it can be implanted within the animal, it is refillable, and it is programmable...
- Japanese macaques as laboratory animals
Section for NBR Promotion, National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan
Exp Anim 58:451-7. 2009
..The project is in progress and should lead to the establishment of a National Primate Center in Japan, which will support the supply of monkeys as well as social outreach and handling of animal welfare issues...
- Molecular characterization of pneumococcal isolates from pets and laboratory animals
Mark van der Linden
Department of Medical Microbiology, National Reference Center for Streptococci, University Hospital RWTH, Aachen, Germany
PLoS ONE 4:e8286. 2009
..dolphins (n = 2), rat (n = 2), gorilla (n = 1)) treated in medical veterinary laboratories and zoos, and 44 laboratory animals (mastomys (multimammate mice; n = 32), mice (n = 6), rats (n = 4), guinea pigs (n = 2)) during routine ..
- Comparable measures of cognitive function in human infants and laboratory animals to identify environmental health risks to children
Westat, Rockville, Maryland, USA
Environ Health Perspect 111:1630-9. 2003
..examining measures of cognitive function that can be applied to both human infants (0-12 months old) and laboratory animals. We begin with a discussion of the definition of cognitive function and important considerations in cross-..
- Laboratory animal welfare: cage enrichment and mouse behaviour
David P Wolfer
Division of Neuroanatomy and Behaviour, Institute of Anatomy, University of Zurich, 8057 Zurich, Switzerland
Nature 432:821-2. 2004
..Our findings indicate that the housing conditions of laboratory mice can be markedly improved without affecting the standardization of results...
- Scientific procedures on living animals in Great Britain in 2003: the facts, figures and consequences
FRAME, Russell and Burch House, 96 98 North Sherwood Street, Nottingham NG1 4EE, UK
Altern Lab Anim 32:473-85. 2004
..The implications of these latest statistics are discussed with reference to key areas of interest and to the impact of existing regulations and pending legislative reforms...
- To enrich or not to enrich: providing shelter does not complicate handling of laboratory mice
Christel P H Moons
Animal Nutrition, Genetics, Breeding and Ethology, Faculty of Veterinary Medicine, Ghent University, Belgium
Contemp Top Lab Anim Sci 43:18-21. 2004
..does not complicate catching or handling mice and that allowing access to enrichment in the laboratory cage, which has been shown to have positive effects on welfare, does not interfere with the management or cost of laboratory animals.
- Assessment of the use of two commercially available environmental enrichments by laboratory mice by preference testing
Pascalle L P Van Loo
Department of Laboratory Animal Science, Utrecht University, The Netherlands
Lab Anim 39:58-67. 2005
In the field of biomedical research, the demand for standardization of environmental enrichment for laboratory animals is growing. For laboratory mice, a wide variety of environmental enrichment items are commercially available...
- Environmental enrichment options for laboratory rats and mice
National Institute for Medical Research, Medical Research Council, The Ridgeway, Mill Hill, London NW7 1AA
Lab Anim (NY) 33:39-44. 2004
- Environmental enrichment: room for reduction?
Heleen A Van de Weerd
Department of Laboratory Animal Science, Faculty of Veterinary Medicine, Utrecht University, P O Box 80 166, 3508 TD Utrecht, The Netherlands
Altern Lab Anim 32:69-71. 2004
- Effects of an individually ventilated cage system on the airway integrity of rats (Rattus norvegicus) in a laboratory in Brazil
M A Teixeira
Centro de Ciencias Biologicas e da Saude, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil
Lab Anim 40:419-31. 2006
- Husbandry refinements for rats, mice, dogs and non-human primates used in telemetry procedures. Seventh report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement, Part B
Research Animals Department, RSPCA, Wilberforce Way, Southwater, West Sussex, RH13 9RS, UK
Lab Anim 38:1-10. 2004
- Issues to consider for preparing ferrets as research subjects in the laboratory
Roberta Scipioni Ball
Department of Animal Health, Marshall BioResources, North Rose, NY, USA
ILAR J 47:348-57. 2006
..Ferrets have a distinct niche in biomedical research and are hardy animals that thrive well in the laboratory...
- A renewed look at laboratory rodent housing and management
Janet C Gonder
Garber Consulting LLC, Pinehurst, NC, USA
ILAR J 48:29-36. 2007
Since its publication in 1996, the Guide for the Care and Use of Laboratory Animals (National Research Council, Washington DC, National Academy Press) has become a primary source of information for institutional animal care and use ..
- Survey of environmental enhancement programs for laboratory primates
Kate C Baker
Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, Louisiana 70433, USA
Am J Primatol 69:377-94. 2007
..The data from this survey may be useful for anticipating future program evaluations, establishing more effective internal evaluations, and assessing program progress and resource allocation...
- Reflecting on refinement
Lab Anim (NY) 31:9. 2002
- Animal health assurance
BioResources Consulting, Wayne, Pennsylvania, USA
Curr Protoc Neurosci . 2002
A program to assure the health of laboratory animals and to provide a stable environment for their maintenance is necessary to reduce unwanted variables or complicating factors in experimentation...
- Training nonhuman primates to cooperate with scientific procedures in applied biomedical research
Biomedical Sciences, Dstl Porton Down, Salisbury, Wiltshire, England
J Appl Anim Welf Sci 6:199-207. 2003
..The importance of discussion and consideration of alternative procedures cannot be overemphasized...
- Introduction: environmental enrichment
Thomas L Wolfle
Institute for Laboratory Animal Research, Washington, DC, USA
ILAR J 46:79-82. 2005
- USDA perspective on environmental enrichment for animals
Jodie A Kulpa-Eddy
United States Department of Agriculture, Animal and Plant Health Inspection Service, Riverdale, MD, USA
ILAR J 46:83-94. 2005
- Considerations in the selection and conditioning of Old World monkeys for laboratory research: animals from domestic sources
John P Capitanio
California National Primate Research Center, University of California, Davis, CA, USA
ILAR J 47:294-306. 2006
..Attention to issues of animal selection and conditioning by both researchers and colony managers can lead to the shared goal of high-quality research that utilizes the minimal number of animals...
- Laboratory environments and rodents' behavioural needs: a review
J P Balcombe
Physicians Committee for Responsible Medicine, 5100 Wisconsin Avenue, NW, Suite 400, Washington, DC 20016, USA
Lab Anim 40:217-35. 2006
..Adding environmental 'enrichments' to small cages reduces but does not eliminate these problems, and I argue that substantial changes in housing and husbandry conditions would be needed to further reduce them...
- Management of unanticipated outcomes in transgenic mouse facilities
Covance Research Products, Inc, Denver, PA 17517, USA
Lab Anim (NY) 35:27-30. 2006
- Selection, acclimation, training, and preparation of dogs for the research setting
LaVonne D Meunier
Department of Laboratory Animal Science, GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, USA
ILAR J 47:326-47. 2006
..Canine socialization and training programs provided by skilled personnel, together with comprehensive veterinary health programs, can further enhance animal welfare and minimize interanimal and group variability in studies...
- Behavioral assessment of intermittent wheel running and individual housing in mice in the laboratory
Therese M Pham
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
J Appl Anim Welf Sci 8:157-73. 2005
..Intermittent withdrawal of individual housing affects the animals more than other commodities. Wheel running normalizes some effects of intermittent separation from the enriched, social home cage...
- Balancing animal well-being, cost, and employee health and safety in caging design and selection
Eli Lilly and Company, Indianapolis, Indiana, USA
Contemp Top Lab Anim Sci 44:68-71. 2005
- Preparation of swine for the laboratory
Alison C Smith
Department of Comparative Medicine, Medical University of South Carolina, Charleston, SC, USA
ILAR J 47:358-63. 2006
..This manuscript provides an overview of best practices that have been utilized in the authors' facility...
- Introduction to the 3Rs (refinement, reduction and replacement)
Pfizer Animal Health, Vet Med R and D Pharmaceuticals Discovery, Sandwich, Kent, United Kingdom
Contemp Top Lab Anim Sci 44:58-9. 2005
- Behavioral management of chimpanzees in biomedical research facilities: the state of the science
Mollie A Bloomsmith
Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
ILAR J 46:192-201. 2005
..The next challenge is to implement effectively and thoroughly the approaches that have been shown to be beneficial...
- Environmental enrichment for nonhuman primates: theory and application
Corrine K Lutz
Division of Behavioral Biology, New England Primate Research Center, Harvard Medical School, Southborough, MA, USA
ILAR J 46:178-91. 2005
..Only social contact satisfies the goal of promoting a wide variety of species-typical activities while at the same time reducing or preventing the development of abnormal behavior...
- Environmental enrichment for laboratory rodents and rabbits: requirements of rodents, rabbits, and research
Karolinska Institutet, Stockholm, Sweden
ILAR J 46:162-70. 2005
..However, housing systems for laboratory animals have often been designed on the basis of economic and ergonomic aspects...
- Environmental enrichment for laboratory rodents
Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
ILAR J 46:148-61. 2005
..Survey data on current enrichment practices in a large multi-institutional organization are presented, and practical aspects requiring consideration when devising a rodent enrichment program are discussed...
- Balancing animal research with animal well-being: establishment of goals and harmonization of approaches
James L Weed
Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA
ILAR J 46:118-28. 2005
..Better documentation of environmental variables and their correlation with experimental results will promote critical knowledge about the relationships between an animal's environment, its well-being, and science...
- Stereotypies and other abnormal repetitive behaviors: potential impact on validity, reliability, and replicability of scientific outcomes
Joseph P Garner
Department of Animals Sciences, Purdue University, West Lafayette, IN, USA
ILAR J 46:106-17. 2005
..Thus, ARBs in laboratory animals may compromise validity, reliability, and replicability, especially in behavioral experiments; and ..
- Preparation of animals for research--issues to consider for rodents and rabbits
Laura A Conour
Department of Veterinary Services, Charles River Laboratories Charles River, Wilmington, MA, USA
ILAR J 47:283-93. 2006
..Stress and distress are placed in perspective as they relate to the preparation of laboratory animals for research.
- Activists seek personhood for animals
R Scott Nolen
J Am Vet Med Assoc 223:759-60. 2003
- Of mice and their environments
John C Crabbe
Science 299:1313-4. 2003
- The rehabilitation of captive baboons
Department of Laboratory Animal Medicine, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549, USA
J Med Primatol 30:71-80. 2001
..This study provides evidence that even behaviorally disturbed nonhuman primates can be successfully rehabilitated to live in social groups...
- Environmental enrichment of nonhuman primates, dogs and rabbits used in toxicology studies
Kathryn A L Bayne
AAALAC International, Rockville, Maryland 20842, USA
Toxicol Pathol 31:132-7. 2003
The increasing emphasis on the provision of environmental enrichment to laboratory animals, vis-à-vis the USDA Animal Welfare Regulations, the Guide for the Care and Use of Laboratory Animals (NRC 1996), and a potential forthcoming ..
- The impact of reduced frequency of cage changes on the health of mice housed in ventilated cages
C K Reeb-Whitaker
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Lab Anim 35:58-73. 2001
..In conclusion, under the conditions of this study, cage changes once every 14 days and ventilation rates of 60 ACH provide optimum conditions for animal health and practical husbandry...
- Are "by-stander" female Sprague-Dawley rats affected by experimental procedures?
Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
Contemp Top Lab Anim Sci 42:19-27. 2003
..Finally, group housing often, but not always, reduces the stress-like responses that can occur in female by-stander rats...
- Automated mouse euthanasia in an individually ventilated caging system: system development and assessment
Alyssa R McIntyre
Tri Institutional Training Program in Laboratory Animal Medicine and Science, Memorial Sloan Kettering Cancer Center, Rockefeller University, New York, NY, USA
J Am Assoc Lab Anim Sci 46:65-73. 2007
..This system was safe, effective, and labor-saving for euthanizing large numbers of mice in an aesthetically acceptable and humane manner compatible with recommendations provided in the ACLAM 2005 Report on Euthanasia...
- Report of the 2006 RSPCA/UFAW Rodent Welfare Group meeting
Research Animals Department, Science Group, RSPCA, Wilberforce Way, Southwater, West Sussex RH13 9RS, UK
Lab Anim (NY) 37:216-22. 2008
..Topics included the housing and husbandry of mice and rats, refining the use of rodents in asthma research, good practice for the euthanasia of rodents using carbon dioxide and achieving reduction by sharing genetically modified mice...
- A comprehensive, barcoded system for the management of animal information in a research facility
Lab Animal Resources, Merck Research Laboratories, PO Box 4, WP44-201, Sumneytown Pike, West Point, PA 19486, USA
Lab Anim (NY) 30:36-8. 2001
..The authors describe an easy-to-use barcode-based animal tracking system that has improved record keeping and data retrieval and proved instrumental in the containment of an outbreak...
- Should clinical complications affect USDA pain categories? C is correct
Gail T Colbern
Laboratory Animal Resources at Genentech, Inc, 1 DNA Way, MS 72, South San Francisco, CA, USA
Lab Anim (NY) 36:14. 2007
- Affordable noise control in a laboratory animal facility
David L Carlton
Laboratory Animal Resources and Research, Texas A and M University, Building 972, Agronomy Road, College Station, TX 77843 4473, USA
Lab Anim (NY) 31:47-8. 2002