inbred shr rats

Summary

Summary: A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.

Top Publications

  1. ncbi Hypertension in the spontaneously hypertensive rat is linked to the Y chromosome
    D L Ely
    Department of Biology, University of Akron, Ohio 44325
    Hypertension 16:277-81. 1990
  2. ncbi Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats
    J F Reckelhoff
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 31:435-9. 1998
  3. ncbi Location of resistance arteries
    K L Christensen
    Department of Pharmacology, University of Aarhus, Denmark
    J Vasc Res 38:1-12. 2001
  4. ncbi Blood pressure variability is more important than blood pressure level in determination of end-organ damage in rats
    Chao Yu Miao
    Department of Pharmacology, Second Military Medical University, Shanghai, China
    J Hypertens 24:1125-35. 2006
  5. ncbi HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species
    S Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Hamburg/Saar, Germany
    Hypertension 37:1450-7. 2001
  6. ncbi Reciprocal rat chromosome 2 congenic strains reveal contrasting blood pressure and heart rate QTL
    Adamu Alemayehu
    Department of Pharmacology, University of California San Diego, La Jolla, California 92093 0636, USA
    Physiol Genomics 10:199-210. 2002
  7. ncbi Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat
    H J Jacob
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 67:213-24. 1991
  8. ncbi Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition
    Torsten Schlüter
    Department of Physiology, University of Greifswald, Greifswalder Street 11C, D17495 Greifswald, Karlsburg, Germany
    Cardiovasc Res 80:271-9. 2008
  9. ncbi Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat
    Michal Pravenec
    Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Hypertension 51:148-53. 2008
  10. ncbi Oxidative impairment of mitochondrial electron transport chain complexes in rostral ventrolateral medulla contributes to neurogenic hypertension
    Samuel H H Chan
    Center for Translational Research in Biomedical Sciences, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan, Republic of China
    Hypertension 53:217-27. 2009

Detail Information

Publications241 found, 100 shown here

  1. ncbi Hypertension in the spontaneously hypertensive rat is linked to the Y chromosome
    D L Ely
    Department of Biology, University of Akron, Ohio 44325
    Hypertension 16:277-81. 1990
    ..The data strongly suggest that hypertension in the SHR has two primary components of equal magnitude, one consisting of a small number of autosomal loci with a second Y-linked component...
  2. ncbi Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats
    J F Reckelhoff
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Hypertension 31:435-9. 1998
    ..Pressure-natriuresis was also blunted in ovx+T females as found in intact male SHR. These data support the hypothesis that male sex hormones contribute to the exacerbation of hypertension in SHR by reducing pressure-natriuresis...
  3. ncbi Location of resistance arteries
    K L Christensen
    Department of Pharmacology, University of Aarhus, Denmark
    J Vasc Res 38:1-12. 2001
    ..Furthermore, evidence concerning man is not available. We therefore conclude the review with suggestions for future research in this area...
  4. ncbi Blood pressure variability is more important than blood pressure level in determination of end-organ damage in rats
    Chao Yu Miao
    Department of Pharmacology, Second Military Medical University, Shanghai, China
    J Hypertens 24:1125-35. 2006
    ..This study was designed to determine how important a novel risk factor of elevated blood pressure variability (BPV) is in the determination of end-organ damage by comparison with the classic risk factor of a high blood pressure (BP) level...
  5. ncbi HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species
    S Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Hamburg/Saar, Germany
    Hypertension 37:1450-7. 2001
    ....
  6. ncbi Reciprocal rat chromosome 2 congenic strains reveal contrasting blood pressure and heart rate QTL
    Adamu Alemayehu
    Department of Pharmacology, University of California San Diego, La Jolla, California 92093 0636, USA
    Physiol Genomics 10:199-210. 2002
    ..Taken together with our other studies, we conclude that rat chromosome 2 is rich in alleles for cardiovascular and behavioral traits and for coordinated coupling between behavior and cardiovascular responses...
  7. ncbi Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat
    H J Jacob
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 67:213-24. 1991
    ..We also find significant, albeit weaker, linkage to a locus, Bp2, on chromosome 18. We discuss the implications of genetic dissection of quantitative disease-related phenotypes in mammals...
  8. ncbi Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition
    Torsten Schlüter
    Department of Physiology, University of Greifswald, Greifswalder Street 11C, D17495 Greifswald, Karlsburg, Germany
    Cardiovasc Res 80:271-9. 2008
    ..Further experiments were performed in normotensive rats and in NADPH oxidase subunit knock-out mice to test if apocynin-induced vasodilation depends on NADPH oxidase inhibition at all...
  9. ncbi Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat
    Michal Pravenec
    Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Hypertension 51:148-53. 2008
    ....
  10. ncbi Oxidative impairment of mitochondrial electron transport chain complexes in rostral ventrolateral medulla contributes to neurogenic hypertension
    Samuel H H Chan
    Center for Translational Research in Biomedical Sciences, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan, Republic of China
    Hypertension 53:217-27. 2009
    ..and ETC enzymes contribute to chronic oxidative stress in the RVLM of spontaneously hypertensive rats, leading to augmented sympathetic vasomotor tone and hypertension...
  11. pmc NF-kappaB inhibition is involved in tobacco smoke-induced apoptosis in the lungs of rats
    Cai Yun Zhong
    Center for Health and the Environment, University of California, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 230:150-8. 2008
    ..Tobacco smoke exposure did not alter the levels of p53 and Bax proteins. These findings suggest the role of NF-kappaB pathway in tobacco smoke-induced apoptosis...
  12. ncbi Maternal supplementation with citrulline increases renal nitric oxide in young spontaneously hypertensive rats and has long-term antihypertensive effects
    Maarten P Koeners
    Department of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands
    Hypertension 50:1077-84. 2007
    ..This early renal deficiency and its adverse sequels can be corrected by perinatal citrulline supplementation persistently in female and transiently in male SHRs...
  13. pmc Implication of chromosome 13 on hypertension and associated disorders in Lyon hypertensive rats
    Sophie Gilibert
    Universite de Lyon, Université Lyon1, Departement de Physiologie et Pharmacologie Clinique, Faculte de Pharmacie, Lyon, France
    J Hypertens 27:1186-93. 2009
    ..Previous genetic mapping identified quantitative trait loci (QTLs) influencing blood pressure (BP) on rat chromosome 13 (RNO13) in several models of hypertension...
  14. ncbi Sleep-related sympathovagal imbalance in SHR
    Terry B J Kuo
    Dept of Physiology, Tzu Chi Univ, 701, Sect 3, Chung Yang Rd, Hualien 970, Taiwan
    Am J Physiol Heart Circ Physiol 286:H1170-6. 2004
    ..We concluded that significant cardiac sympathovagal imbalance with an increased sympathetic modulation occurred in SHR during sleep, although it was less evident during waking...
  15. ncbi Sleep-related changes in cardiovascular neural regulation in spontaneously hypertensive rats
    Terry B J Kuo
    Institute of Neuroscience, Department of Physiology, Tzu Chi University, Tzu Chi Buddhist General Hospital, Hualien, Taiwan
    Circulation 112:849-54. 2005
    ..The aim of this study is to explore the possible change in sympathetic vasomotor activity and baroreflex sensitivity associated with spontaneous hypertension during each stage of the sleep-wake cycle...
  16. pmc Attenuation of conducted vasodilatation in rat mesenteric arteries during hypertension: role of inwardly rectifying potassium channels
    Kenichi Goto
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 0200, Australia
    J Physiol 561:215-31. 2004
    ....
  17. ncbi Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat
    M Pravenec
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Mamm Genome 12:295-8. 2001
    ....
  18. ncbi Effects of omapatrilat in low, normal, and high renin experimental hypertension
    N C Trippodo
    The Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000, USA
    Am J Hypertens 11:363-72. 1998
    ..Omapatrilat has the potential to be an effective, broad spectrum antihypertensive agent...
  19. ncbi Influence of sources of dietary oils on the life span of stroke-prone spontaneously hypertensive rats
    W M Ratnayake
    Nutrition Research Division, Food Directorate, Health Protection Branch, Health Canada, Ottawa, Ontario
    Lipids 35:409-20. 2000
    ....
  20. ncbi Analogy of cardiac and renal complications in essential hypertension and aged SHR or L-NAME/SHR
    Xiaoyan Zhou
    Ochsner Clinic Foundation, 1516 Jefferson Highway, New Orleans, LA 70121, USA
    Med Chem 3:61-5. 2007
    ..The latter hypertensive rat model with induced endothelial dysfunction is recommended enthusiastically for its foregoing as well as time-saving and economic values...
  21. ncbi Gene expression profiling and functional proteomic analysis reveal perturbed kinase-mediated signaling in genetic stroke susceptibility
    Myriam Fornage
    Houston Institute of Molecular Medicine, University of Texas, Houston, USA
    Physiol Genomics 15:75-83. 2003
    ..Altered gene and protein expression patterns in SHRSP are consistent with increased vulnerability of this strain to cerebrovascular injury...
  22. ncbi Vasopeptidase inhibition prevents target organ damage and improves survival in spontaneously hypertensive rats
    Wolfgang Linz
    Therapeutic Department Cardiovascular Diseases, Sanofi Aventis Deutschland GmbH, Frankfurt am Main, Germany
    J Renin Angiotensin Aldosterone Syst 7:155-61. 2006
    ..We investigated the myocardial, vascular and renal effects of chronic vasopeptidase inhibition in arterial hypertension...
  23. ncbi Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats
    Dan Li
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, UK
    Hypertension 50:69-74. 2007
    ..We conclude that artificial upregulation of sympathetic nNOS via gene transfer with a noradrenergic promoter may provide a novel approach for correcting peripheral sympathetic hyperactivity in hypertension...
  24. ncbi Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat: congenic analysis
    Delyth Graham
    BHF Glasgow Cardiovascular Research Centre, 126 University Pl, Glasgow, G12 8TA United Kingdom
    Hypertension 50:1134-41. 2007
    ..This region contains several physiological candidate genes for salt-sensitive hypertension in the SHRSP, including Edg1 and Vcam1, which are differentially expressed and lie on common and functionally important pathways...
  25. ncbi Clonidine, moxonidine, folic acid, and mecobalamin improve baroreflex function in stroke-prone, spontaneously hypertensive rats
    Xiu juan Ma
    Department of Pharmacology, Second Military Medical University, Shanghai 200433, China
    Acta Pharmacol Sin 28:1550-8. 2007
    ..To investigate the effect of clonidine, moxonidine, folic acid, and mecobalamin on arterial baroreflex (ABR) function in stroke-prone spontaneously hypertensive rats (SHR-SP) and the possible mechanisms involved...
  26. ncbi Reduced expression of GSTM2 and increased oxidative stress in spontaneously hypertensive rat
    Si Gui Zhou
    Pharmacology and Toxicology Laboratory, School of Pharmaceutical Sciences, Sun Yat Sen University, 74 Zhongshan II Road, Guangzhou 510080, PR China
    Mol Cell Biochem 309:99-107. 2008
    ....
  27. ncbi Acute tobacco smoke-induced airways inflammation in spontaneously hypertensive rats
    Bei Yu
    Center for Health and the Environment, University of California, Davis, California 95616, USA
    Inhal Toxicol 20:623-33. 2008
    ..The spontaneously hypertensive rat may be a more relevant animal model of acute tobacco smoke-induced airway inflammation than other laboratory rats...
  28. ncbi Noradrenergic content and turnover rate in kidney and heart shows gender and strain differences
    Ann Caplea
    Department of Biology, The University of Akron, Akron, Ohio 44325 3908, USA
    J Appl Physiol 92:567-71. 2002
    ..This study suggests both a strain and gender difference in sympathetic nervous system activity through noradrenergic neurotransmission...
  29. ncbi Angiotensin receptors contribute to blood pressure homeostasis in salt-depleted SHR
    Shigefumi Nakamura
    Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Physiol Regul Integr Comp Physiol 284:R164-73. 2003
    ..Combined blockade of AT(2) and AT((1-7)) receptors and ANG II neutralization by the ANG II antibody reversed as much as 67% of the blood pressure-lowering effect of losartan...
  30. ncbi Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy
    Norbert Zilka
    Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovak Republic
    J Neuroimmunol 209:16-25. 2009
    ..These findings have important consequences for the rationale drug development of effective inflammation-based therapeutic strategies for human tauopathies...
  31. ncbi Acute and chronic effects of free radicals on alpha1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats
    Helene Girouard
    Research Group on Autonomic Nervous System, Department of Physiology, Faculty of Medicine, University of Montreal, Montreal Quebec, Canada
    J Hypertens 23:807-14. 2005
    ..To determine whether free radicals participate in the increased sensitivity of the alpha-adrenergic pathway in mesenteric arteries from spontaneously hypertensive rats (SHRs)...
  32. ncbi Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension
    M Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Physiol Res 52:681-8. 2003
    ....
  33. ncbi Inhibition of tobacco smoke-induced lung inflammation by a catalytic antioxidant
    Kevin R Smith
    Center for Health and the Environment, University of California, Davis, CA 95616, USA
    Free Radic Biol Med 33:1106-14. 2002
    ..05). We conclude that a synthetic catalytic antioxidant decreased the adverse effects of exposure to tobacco smoke...
  34. ncbi Acute effects of fine particles on cardiovascular system: differences between the spontaneously hypertensive rats and wistar kyoto rats
    Jinzhuo Zhao
    Department of Environment Health, School of Public Health, Fudan University, Shanghai, China
    Toxicol Lett 193:50-60. 2010
    ..Different response between SHR and WKY rats after exposed to fine particles indicated that SHR was more susceptible than WKY rats to acute cardiac impairments from fine particle exposure...
  35. ncbi Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats
    T J Aitman
    Molecular Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Nat Genet 16:197-201. 1997
    ....
  36. ncbi 1H NMR-based metabonomic analysis of urine from young spontaneously hypertensive rats
    Kazuki Akira
    College of Pharmaceutical Sciences, Matsuyama University, 4 2 Bunkyo cho, Matsuyama, Ehime 790 8578, Japan
    J Pharm Biomed Anal 46:550-6. 2008
    ..The present study suggests the usefulness of a (1)H NMR-based metabonomic approach using SHR in the field of hypertension research...
  37. ncbi Beneficial pleiotropic vascular effects of rosuvastatin in two hypertensive models
    Dinko Susic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    J Am Coll Cardiol 42:1091-7. 2003
    ..The goal of this research was to study the effects of rosuvastatin on systemic and regional hemodynamics in two hypertensive rat models, one genetic, the other induced with inhibition of nitric oxide synthesis...
  38. ncbi Effects of concentrated ambient particles on heart rate variability in spontaneously hypertensive rats
    Chuen Chau Chang
    Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University
    J Occup Health 47:471-80. 2005
    ..Our results indicate that concentrated PM(2.5) may decrease SDNN on SH rats during PM exposure. The study also showed that SDNN is more sensitive to PM induced effects than RMSSD...
  39. ncbi A model of chronic heart failure in spontaneous hypertensive rats (SHR)
    G Itter
    Aventis Pharma Deutschland, DG Cardiovascular Diseases, D 65926 Frankfurt Main, Germany
    Lab Anim 38:138-48. 2004
    ..Furthermore the infarcted animals showed enhanced levels of hydroxyproline/proline ratios, again much more so in the SHR/NHsd rat than in the WKY/NHsd rat...
  40. ncbi Soyabean protein hydrolysate prevents the development of hypertension in spontaneously hypertensive rats
    Hsin Yi Yang
    Department of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
    Br J Nutr 92:507-12. 2004
    ..The results suggest that the long-term administration of soyabean protein hydrolysate might retard the development of hypertension in SHR by its inhibitory effect on ACE in vivo...
  41. ncbi Intramuscular delivery of rAAV-mediated kallikrein gene reduces hypertension and prevents cardiovascular injuries in model rats
    Tao Wang
    Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Acta Pharmacol Sin 28:1898-906. 2007
    ..The current study was designed to investigate hypotensive effect of intramuscular delivery of HK gene...
  42. ncbi Different effects of 26-week dietary intake of rapeseed oil and soybean oil on plasma lipid levels, glucose-6-phosphate dehydrogenase activity and cyclooxygenase-2 expression in spontaneously hypertensive rats
    Naoki Ohara
    Division of Toxicology, Hatano Research Institute, Food and Drug Safety Center, Ochiai 729 5, Hadano, Kanagawa 257 8523, Japan
    Food Chem Toxicol 46:2573-9. 2008
    ..The increased COX-2 expression indicates a role of renin-angiotensin-aldosterone system activation in the increased vascular lesions, whereas the effects of oxidative stress remain unclear...
  43. ncbi Gas chromatography/time-of-flight mass spectrometry based metabonomic approach to differentiating hypertension- and age-related metabolic variation in spontaneously hypertensive rats
    Yihong Lu
    Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China
    Rapid Commun Mass Spectrom 22:2882-8. 2008
    ..It is also indicated that GC/TOFMS-based metabonomics is a powerful approach to identifying potential biomarkers and investigating the pathological processes of hypertension and the physiological developments of aging...
  44. ncbi Increasing oxidative stress with molsidomine increases blood pressure in genetically hypertensive rats but not normotensive controls
    Lourdes A Fortepiani
    Dept of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 289:R763-70. 2005
    ..Increasing oxidative stress elevated blood pressure further in SHR but not WKY. WKY are likely protected because of higher bioavailable levels of NO and the ability to upregulate catalase and GPx...
  45. ncbi Local RAS and inflammatory factors are involved in cardiovascular hypertrophy in spontaneously hypertensive rats
    Ling Li
    Department of Pharmacology, Second Military Medical University, Shanghai, China
    Pharmacol Res 58:196-201. 2008
    ..Statistically, LV hypertrophy was mainly determined by diastolic blood pressure and the cardiac angiotensin-converting enzyme gene expression, and aortic hypertrophy was mainly correlated with baroreflex sensitivity...
  46. ncbi Is the balance between nitric oxide and superoxide altered in spontaneously hypertensive rats with endothelial dysfunction?
    G Zalba
    Division of Cardiovascular Pathophysiology, School of Medicine, University of Navarra, Pamplona, Spain
    Nephrol Dial Transplant 16:2-5. 2001
    ..This study was designed to test the hypothesis that increased O2(.-) production, more than diminished nitric oxide (NO) generation, plays a critical role in endothelial dysfunction present in spontaneously hypertensive rats (SHR)...
  47. ncbi Quantitative trait loci in genetically hypertensive rats. Possible sex specificity
    J S Clark
    Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, Scotland
    Hypertension 28:898-906. 1996
    ..1). The sex specificity of blood pressure quantitative trait loci will be important in designing congenic strains and substrains for fine genetic mapping and for identifying genes that regulate blood pressure...
  48. ncbi Ramipril prevents extracellular matrix accumulation in cerebral microvessels
    Martin Liebetrau
    Department of Neurology, Dr Horst Schmidt Klinik, Ludwig Erhard Str 100, 65199 Wiesbaden, Germany
    Neurol Res 27:477-82. 2005
    ..The aim of this study was to determine the influence of chronic hypertension and ramipril treatment on the extracellular matrix in the cerebral microvasculature...
  49. ncbi Monocyte adhesion to cerebromicrovascular endothelial cells derived from hypertensive and normotensive rats
    R M McCarron
    Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892
    Am J Physiol 267:H2491-7. 1994
    ..In summary, these findings indicate hypertension may enhance responsiveness of endothelium to factors that promote monocyte adhesion...
  50. ncbi Arterial hypertension exacerbates oxidative stress in early diabetic retinopathy
    Camila C Pinto
    Renal Pathophysiology Laboratory, Department of Internal Medicine, Faculty of Medical Sciences FCM, State University of Campinas, Campinas, Sao Paulo, Brazil
    Free Radic Res 41:1151-8. 2007
    ..0001). Hypertension aggravates oxidative-induced cytotoxicity in diabetic retina due to increasing of superoxide production and impairment of antioxidative system...
  51. ncbi Long-term arterial pressure in spontaneously hypertensive rats is set by the kidney
    Olaf Grisk
    Department of Physiology, University of Greifswald, Greifswalder Strasse 11c, D 17495 Karlsburg, Germany
    J Hypertens 20:131-8. 2002
    ..In addition, the effect of differential genetic predisposition to hypertension of recipients of an SHR kidney on the development of post-transplantation hypertension was studied...
  52. ncbi Dietary lipids impacts on healthy ageing
    Harumi Okuyama
    Laboratory of Preventive Nutraceutical Sciences, Kinjo Gakuin University College of Pharmacy, 2 1723 Omori, Moriyamaku, Nagoya, 463 8521, Japan
    Lipids 42:821-5. 2007
    ..Thus, factors other than fatty acids (omega6/omega3 balance) and phytosterols must be taken into account when fats and oils are evaluated in relation to healthy ageing...
  53. ncbi Phytosterol additives increase blood pressure and promote stroke onset in salt-loaded stroke-prone spontaneously hypertensive rats
    Hiroshi Ogawa
    Department of Hygiene and Division of Basic Medical Science, Kinki University School of Medicine, Osaka Sayama City, Osaka, Japan
    Clin Exp Pharmacol Physiol 30:919-24. 2003
    ..The significant decrease in the intestinal mRNA expression of Abcg5 and Abcg8 in SHRSP may be responsible, at least in part, for the unfavourable effects observed following the addition of phytosterol...
  54. ncbi Antihypertensive activity of chitin derivatives
    Jae Young Je
    Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    Biopolymers 83:250-4. 2006
    ..021 microM. In addition, the antihypertensive effect of AEC50 on spontaneously hypertensive rats (SHR) was evaluated, and the result showed that it effectively decreased systolic blood pressure (SBP) in a dose-dependent manner...
  55. ncbi Cellular aspects of vascular remodeling in hypertension revealed by confocal microscopy
    S M Arribas
    Clinical Research Initiative in Heart Failure, Institute of Biomedical and Life Sciences, Western Infirmary, University of Glasgow, UK
    Hypertension 30:1455-64. 1997
    ....
  56. ncbi Circulating succinate is elevated in rodent models of hypertension and metabolic disease
    Nalini Sadagopan
    Pfizer Global Research and Development, Ann Arbor, Michigan, USA
    Am J Hypertens 20:1209-15. 2007
    ..We sought to test the hypothesis that GPR91 contributes to BP elevation in hypertension. In addition we investigated whether elevated succinate in diabetes could contribute to the increased rate of gluconeogenesis in that condition...
  57. ncbi Factors other than phytosterols in some vegetable oils affect the survival of SHRSP rats
    Kenjiro Tatematsu
    Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabedori, Mizuhoku, Nagoya 467 8603, Japan
    Food Chem Toxicol 42:1443-51. 2004
    ..These results indicate that factors other than PS, tocopherol status and fatty acid composition in some vegetable oils are critical for the survival-shortening activity observed in SHRSP rats...
  58. ncbi Remodeling of the cardiac pacemaker L-type calcium current and its beta-adrenergic responsiveness in hypertension after neuronal NO synthase gene transfer
    Daniel A Heaton
    Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, Oxford, United Kingdom
    Hypertension 48:443-52. 2006
    ..Decreased calcium current after cardiac nNOS gene transfer contributes to the normalization of beta-adrenergic hyperresponsiveness in the SAN from hypertensive rats by modulating cyclic nucleotide signaling...
  59. ncbi Inhaled environmental combustion particles cause myocardial injury in the Wistar Kyoto rat
    Urmila P Kodavanti
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 71:237-45. 2003
    ..These findings provide supportive evidence for the epidemiological associations of cardiovascular morbidity and ambient PM...
  60. ncbi Early and sustained inhibition of nuclear factor-kappaB prevents hypertension in spontaneously hypertensive rats
    Bernardo Rodriguez-Iturbe
    Renal Service, Hospital Universitario, Universidad del Zulia, Instituto de Investigaciones Biomedicas, Maracaibo, Venezuela
    J Pharmacol Exp Ther 315:51-7. 2005
    ..Results suggest that NF-kappaB-driven intrarenal inflammatory reactivity play a major role in the pathogenesis of hypertension in the SHR...
  61. ncbi Oxidative stress in hypertensive,diabetic, and diabetic hypertensive rats
    Joseph Friedman
    A J Chorley Institute for Hypertension, Chaim Sheba Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Hashomer, Israel
    Am J Hypertens 16:1049-52. 2003
    ..Reactive oxygen species play a key role in the formation of endothelial dysfunction accompanying diabetes mellitus, hypertension, and other cardiovascular diseases...
  62. ncbi Age-related changes in blood pressure, hematological values, concentrations of serum biochemical constituents and weights of organs in the SHR/Izm, SHRSP/Izm and WKY/Izm
    Satoshi Fukuda
    International Space Radiation Laboratory, National Institute of Radiological Sciences, Anaganwa, Inage Ku, Chiba shi, Chiba, Japan
    Exp Anim 53:67-72. 2004
    ....
  63. ncbi Persistent lowering of pressure by transplanting kidneys from adult spontaneously hypertensive rats treated with brief antihypertensive therapy
    Corry Smallegange
    Department of Pharmacology and Toxicology, Queen s University, Kingston, Ontario, Canada
    Hypertension 44:89-94. 2004
    ..The findings also suggest that a key pharmacotherapeutic target in hypertension should be kidney-specific changes, such as renal vascular structure...
  64. ncbi Role of androgens in mediating hypertension and renal injury
    J F Reckelhoff
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Clin Exp Pharmacol Physiol 26:127-31. 1999
    ....
  65. ncbi Up-regulation of kidney NAD(P)H oxidase and calcineurin in SHR: reversal by lifelong antioxidant supplementation
    Chang De Zhan
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California, USA
    Kidney Int 65:219-27. 2004
    ..The study further sought to explore the effect of diet modification on renal tissue NAD(P)H oxidase and calcineurin abundance...
  66. ncbi Effects of instilled combustion-derived particles in spontaneously hypertensive rats. Part I: Cardiovascular responses
    L B Wichers
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, USA
    Inhal Toxicol 16:391-405. 2004
    ..This study demonstrates substantial dose-related deficits in cardiac function in SH rats after IT exposure to a low-metal content, combustion-derived particle...
  67. ncbi Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress
    Martin W McBride
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom
    Hypertension 45:786-92. 2005
    ..Coupled to significant increases in nitrotyrosine levels in the kidney, this suggests a pathophysiological role of this protein in hypertension and oxidative stress. Similar processes may underlie oxidative stress in the vasculature...
  68. pmc Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains
    Michal Pravenec
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague 142 20, Czech Republic
    Genome Res 17:1319-26. 2007
    ....
  69. ncbi The spontaneously hypertensive rat: an experimental model of sulfur dioxide-induced airways disease
    Urmila P Kodavanti
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
    Toxicol Sci 94:193-205. 2006
    ..SO(2) effects on these genes were more pronounced in SH than in SD rats. Thus, SO(2) exposure in SH rats may yield a relevant experimental model of bronchitis...
  70. ncbi Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity
    Rocio Vera
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Clin Sci (Lond) 112:183-91. 2007
    ..This latter effect appears to be related to increased eNOS activity associated with increased calmodulin-1 expression and decreased O(2)(-) generation...
  71. ncbi Changes in autonomic activity and baroreflex sensitivity with the hypertension process and age in rats
    Ryuji Nagai
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Exp Pharmacol Physiol 30:419-25. 2003
    ..Therefore, the contribution of autonomic activity to hypertension may be discussed separately as a developmental period and a sustained period...
  72. ncbi Multi-modal characterisation of the neocortical clip model of focal cerebral ischaemia by MRI, behaviour and immunohistochemistry
    Maria Ashioti
    Neuroimaging Research Group, Department of Neurology PO42, Institute of Psychiatry, Kings College London, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Brain Res 1145:177-89. 2007
    ..The correlation of MRI with two different behavioural measures and post-mortem histology strengthens the basis for MRI providing an in vivo surrogate marker for structural and behavioural deficits caused by a cortical stroke...
  73. pmc A cell culture model using rat coronary artery adventitial fibroblasts to measure collagen production
    Cathleen Jenkins
    Kent State University, Kent, Ohio, USA
    BMC Cardiovasc Disord 7:13. 2007
    ..To demonstrate the application of our cell model, cultured adventitial fibroblasts were treated with sex hormones and the effect on collagen production measured...
  74. ncbi Genetic Models in Applied Physiology. HXB/BXH rat recombinant inbred strain platform: a newly enhanced tool for cardiovascular, behavioral, and developmental genetics and genomics
    Morton P Printz
    Department of Pharmacology, University of California San Diego, La Jolla, California 92093 0636, USA
    J Appl Physiol (1985) 94:2510-22. 2003
    ..These strains provide a ready and available vehicle for many physiological and pharmacological studies...
  75. ncbi Hypertension increases retinal inflammation in experimental diabetes: a possible mechanism for aggravation of diabetic retinopathy by hypertension
    Kamila C Silva
    Renal Pathophysiology Laboratory, Faculty of Medical Sciences, State University of Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Curr Eye Res 32:533-41. 2007
    ..Aggravation of the inflammatory process may be involved in the mechanism by which essential hypertension exacerbates retinopathy in the presence of diabetes...
  76. ncbi Blood pressure variability, baroreflex sensitivity and organ damage in spontaneously hypertensive rats treated with various antihypertensive drugs
    He Hui Xie
    Department of Pharmacology, Second Military Medical University, 325 Guo He Road, Shanghai 200433, China
    Eur J Pharmacol 543:77-82. 2006
    ..Besides the blood pressure reduction, the decrease in blood pressure variability and the restoration of baroreflex sensitivity may contribute to this organ protection...
  77. ncbi Renal mitochondrial dysfunction in spontaneously hypertensive rats is attenuated by losartan but not by amlodipine
    Elena M V de Cavanagh
    Physical Chemistry Department, School of Pharmacy and Biochemistry, University of Buenos Aires, Helguera 2365, Buenos Aires 1417, Argentina
    Am J Physiol Regul Integr Comp Physiol 290:R1616-25. 2006
    ..The mitochondrial-antioxidant actions of losartan may be an additional or alternative way to explain some of the beneficial effects of AT1-receptor antagonists...
  78. ncbi Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes
    Cruz A Hinojos
    Institute for Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
    Hypertension 45:698-704. 2005
    ..The present approach identifies a number of genes that may influence blood pressure in SHR by virtue of allelic effects on gene expression...
  79. ncbi Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats
    J M Seubert
    Division of Intramural Research, National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Physiol Renal Physiol 289:F552-61. 2005
    ..Together, our data highlight the complexity of hypertension and the numerous genes involved in and affected by this condition...
  80. ncbi Quinapril effects on resistance artery structure and function in hypertension
    Lufang Yang
    Smooth Muscle Research Programme and Department of Anaesthesia, McMaster University, Hamilton, ON, Canada, L8N 3Z5
    Naunyn Schmiedebergs Arch Pharmacol 370:444-51. 2004
    ..An increase in apoptotic process of medial smooth muscle cells is one of the mechanisms underlying the vascular structural improvement...
  81. ncbi Effect of a gamma-aminobutyric acid-enriched dairy product on the blood pressure of spontaneously hypertensive and normotensive Wistar-Kyoto rats
    Kazuhito Hayakawa
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    Br J Nutr 92:411-7. 2004
    ..The present results suggest that low-dose oral GABA has a hypotensive effect in SHR/Izm and that the hypotensive effect of FMG is due to GABA...
  82. ncbi Nicotianamine preferentially inhibits Angiotensin I-converting enzyme
    Atsumi Hayashi
    Department of Food and Nutrition, Tokyo Kasei University, Tokyo, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:331-6. 2007
    ..These results suggest that the preferential inhibition of circulatory and tissue ACE by NA can contribute to the suppression of hypertension...
  83. ncbi Superoxide dismutase, catalase and glutathione peroxidase in the spontaneously hypertensive rat kidney: effect of antioxidant-rich diet
    Chang De Zhan
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California, USA
    J Hypertens 22:2025-33. 2004
    ..e. superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX)] in the kidney of SHR fed a regular or an antioxidant-rich diet...
  84. ncbi Cardiopulmonary responses of Wistar Kyoto, spontaneously hypertensive, and stroke-prone spontaneously hypertensive rats to particulate matter (PM) exposure
    J Grace Wallenborn
    Department of Environmental Sciences and Engineering, University of North Carolina School of Public Health, Chapel Hill, North Carolina, USA
    J Toxicol Environ Health A 70:1912-22. 2007
    ..Preexisting cardiovascular disease may influence susceptibility to PM pulmonary and cardiac health effects in a disease-specific manner...
  85. ncbi A 14-gene region of rat chromosome 8 in SHR-derived polydactylous congenic substrain affects muscle-specific insulin resistance, dyslipidaemia and visceral adiposity
    O Seda
    Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Folia Biol (Praha) 51:53-61. 2005
    ....
  86. ncbi Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains
    Alison C P Elder
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Inhal Toxicol 16:461-71. 2004
    ....
  87. ncbi Signal transduction pathways involved in particulate matter induced relaxation in rat aorta--spontaneous hypertensive versus Wistar Kyoto rats
    K Bagate
    Particle Research, Institut fur Umweltmedizinische, Forschung IUF, University of Dusseldorf, NRW, Germany
    Toxicol In Vitro 20:52-62. 2006
    ..The purpose of the current study was to investigate the intracellular messengers involved in PM-elicited vasodilatation in aortas from spontaneous hypertensive (SHR) and normotensive (WKY) rats...
  88. ncbi Perinatal L-arginine and antioxidant supplements reduce adult blood pressure in spontaneously hypertensive rats
    Simona Racasan
    Department of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands
    Hypertension 44:83-8. 2004
    ..This suggests a critical role for perinatal pro- and antioxidant balance in programming BP later in life...
  89. pmc Vascular microarray profiling in two models of hypertension identifies caveolin-1, Rgs2 and Rgs5 as antihypertensive targets
    T Hilton Grayson
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    BMC Genomics 8:404. 2007
    ..We studied gene expression and morphology of a saphenous artery branch in normotensive WKY rats, spontaneously hypertensive rats (SHR) and adrenocorticotropic hormone (ACTH)-induced hypertensive rats...
  90. ncbi Sodium directly impairs target organ function in hypertension
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Curr Opin Cardiol 20:424-9. 2005
    ....
  91. ncbi Microarray analysis of rat chromosome 2 congenic strains
    Martin W McBride
    BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow, G11 6NT, Scotland
    Hypertension 41:847-53. 2003
    ..8 x 10(-3); P=0.0034) and WKY 4.03 x 10(-3)+/-5.1 x 10(-4); (95% CI -5.4 x 10(-3) to -8.9 x 10(-4); P=0.027). We also identified regions of conserved synteny, each containing the Gstm2 gene, on mouse chromosome 3 and human chromosome 1...
  92. ncbi Difference of gene expression profiles in spontaneous hypertensive rats and Wistar-Kyoto rats from two sources
    Tomohiko Okuda
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Biochem Biophys Res Commun 296:537-43. 2002
    ..Our study showed the complex nature of the genetic heterogeneity between SHR and WKY from different sources...
  93. ncbi Rosiglitazone fails to improve hypertriglyceridemia and glucose tolerance in CD36-deficient BN.SHR4 congenic rat strain
    Ondrej Seda
    Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Genomics 12:73-8. 2003
    ..Altogether, these results support involvement of CD36 in RSG action, suggesting this pharmacogenetic interaction may be of particular importance in CD36-deficient humans...
  94. ncbi Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness
    Imran M Khan
    Department of Pharmacology, University of California, San Diego, California 92093 0636, USA
    Physiol Genomics 11:65-72. 2002
    ....
  95. pmc Extension of the thrombolytic time window with minocycline in experimental stroke
    Yoshihiro Murata
    Neuroprotection Res Lab, Charlestown, MA 02129, USA
    Stroke 39:3372-7. 2008
    ..In this study, we ask whether minocycline can prevent tPA-associated cerebral hemorrhage and extend the reperfusion window in an experimental stroke model in rats...
  96. ncbi Tyrosine hydroxylase antisense gene therapy causes hypotensive effects in the spontaneously hypertensive rats
    T Kumai
    Department of Pharmacology, St Marianna University School of Medicine, Kawasaki shi, Japan
    J Hypertens 19:1769-73. 2001
    ..These findings suggest that peripheral systemic injection of TH AS ODN may be effective as hypotensive therapy in SHR...
  97. ncbi Blood pressure and proteinuria effects of multiple quantitative trait loci on rat chromosome 9 that differentiate the spontaneously hypertensive rat from the Dahl salt-sensitive rat
    Edward J Toland
    Physiological Genomics Laboratory, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614 5804, USA
    J Hypertens 26:2134-41. 2008
    ....
  98. pmc Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699, USA
    J Clin Invest 95:2170-7. 1995
    ..In F2(S x MNS) functionally variant alleles at both QTL influence blood pressure, but in F2(S x WKY) only the QTL marked by Nos2 is segregating alleles influencing blood pressure...
  99. ncbi The hippocampus in spontaneously hypertensive rats: an animal model of vascular dementia?
    Maurizio Sabbatini
    Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via M Scalzino 5, 62032, Camerino, Italy
    Mech Ageing Dev 123:547-59. 2002
    ..The occurrence in the hippocampus of SHR of regressive changes and astroglial reaction similar to those occurring in neurodegenerative disorders with cognitive impairment suggests that they represent an animal model of vascular dementia...
  100. ncbi Insulin-receptor binding characteristics in perfused SHR and WKY rat hearts
    A B Bikhazi
    Department of Physiology, Faculty of Medicine, American University of Beirut, Lebanon
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 120:127-36. 1998
    ..The results support the hypothesis that insulin-resistance on the myocytes could be a pathophysiologic defect in insulin-receptor structure, function and affinity, and therefore myocardial function...
  101. ncbi Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
    Michal Pravenec
    Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic
    Nat Genet 40:952-4. 2008
    ....

Research Grants62

  1. HYPOTHALAMIC NEURONAL SENSITIVITY IN PREGNANT RATS
    DORANNA CHRISTENSON; Fiscal Year: 1990
    ..Interactions between these factors will be studied; and comparisons made of the various neuronal populations (and their sensitivities) in the pregnant and non-pregnant SHR and WKY animals...
  2. BIOLOGY OF ATRIAL NATRIURETIC FACTOR AND ITS RECEPTORS
    Thomas Maack; Fiscal Year: 2000
    ..The studies are expected to provide novel insights on ANF receptor function and the role of ANF in health and disease. ..
  3. PAIN, OPIOID ANALGESIA AND BLOOD PRESSURE CONTROL
    Bradley Taylor; Fiscal Year: 2002
    ..The results of these studies will facilitate our understanding of the mechanisms that contribute to chronic pain in the hypertensive patient. ..
  4. ROLE OF GABAERGIC NEURONS IN AUTONOMIC NUCLEI
    BANG HWANG; Fiscal Year: 1991
    ..These studies may provide new information on the neural basis of hypertension associated with GABA/VP neurons, which will be useful for drug developments aimed at the treatment or prevention of hypertension...
  5. Pathogenesis of Exercise Pressor Reflex Dysfunction in Hypertension
    ANNA LEAL; Fiscal Year: 2009
    ....
  6. Adrenal decommissioning and hypertension
    Elise Gomez Sanchez; Fiscal Year: 2007
    ..Using similar protocols as those in Aim 1, we will study and compare the process of adrenal decommissioning between SHR-SP and regular SHR rats with emphasis of the ZG genes identified as important in Aim 1. ..
  7. REGULATION OF NA+ REABSORPTION IN RAT COLLECTING DUCT
    C Hawk; Fiscal Year: 1993
    ..This will indicate the fraction of he observed Na+ flux which occurs through an amiloride-sensitive, electrogenic pathway versus a putative electroneutral cotransport pathway or by free diffusion through the paracellular pathway...
  8. ANGIOTENSIN 1-7 IN THE SPONTANEOUSLY HYPERTENSIVE
    Carlos Ferrario; Fiscal Year: 2000
    ..The proposed studies may provide a new understanding of the biochemical physiology of the renin angiotensin system and the mode of action of therapies that depend upon inhibition of ACE and Ang II receptor blockade. ..
  9. Novel PPAR alpha/gamma Agonist for Type 2 Diabetes
    EDWARD AMENTO; Fiscal Year: 2005
    ..Data from these studies will further characterize the potential of THR-0940 for treatment of type 2 diabetes and will provide valuable information to qualify this molecule for entry into clinical development. ..
  10. Estrogen, fatty acyl CoA, & NOS function in hypertension
    MARGARET WEIS; Fiscal Year: 2003
    ..If our hypothesis is correct, then eLCFACoAS might represent a new and novel target for rational drug desian in the treatment of hvpertension. ..
  11. AN ANTIHYPERTENSIVE CLASS OF NEUTRAL LIPIDS IN KIDNEY
    FRED SNYDER; Fiscal Year: 1993
    ....
  12. AT2 Receptors in Cardiovascular Control
    Colin Sumners; Fiscal Year: 2005
    ..We believe that the studies are low risk in nature and will have a high impact on the development of new strategies based on gene targeting, for the treatment of hypertension and cardiovascular disease. ..
  13. CYCLIC AMP/ADENOSINE PATHWAY
    Edwin Jackson; Fiscal Year: 2002
    ..abstract_text> ..
  14. Interaction of age and gender on NO bioavailability
    Jennifer Sullivan; Fiscal Year: 2005
    ..We will then determine the affects of age and gender on antioxidant systems and the sources of oxidative stress in the mesenteric vasculature. ..
  15. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  16. HYPERTENSION: CONTRIBUTION OF ARTERIAL WALL CHANGES
    Robert Cox; Fiscal Year: 2007
    ..These studies will define a novel therapeutic target for antihypertensive drug development based upon the mechanism(s) of Ca2+-Kv channel modulation. ..
  17. Transcription Factors & Inflammatory Mediators in Stroke
    Raghu Vemuganti; Fiscal Year: 2007
    ..The ultimate goal is to define the role of SOCS-3/STAT-3 in post-ischemic cerebral inflammation. ..
  18. Gender and susceptibility to kidney damage in high BP
    Jane F Reckelhoff; Fiscal Year: 2010
    ....
  19. Androgens raise venous and arterial adrenergic tone.
    Douglas S Martin; Fiscal Year: 2010
    ..A better understanding the factors that control arterial and venous tone in hypertension may lead to design antihypertensive drugs with fewer adverse effects ..
  20. Equipment Support for USD Laboratory Animal Services
    Douglas Martin; Fiscal Year: 2005
    ..The long-term goal is to achieve AAALAC accreditation. It is expected that AAALAC review for accreditation will be requested within 18 months of completion and occupancy of the new LAS. ..
  21. Role of Egr-1 in post-stroke inflammation & brain damage
    Raghu Vemuganti; Fiscal Year: 2009
    ..The ultimate goal is to define the role of EgM and its regulators to develop therapies to control cerebral inflammation at the level of transcription. ..
  22. REGULATION OF RENAL VASCULAR CELLS IN HYPERTENSION
    CRAIG GELBAND; Fiscal Year: 2001
    ....
  23. IGF-1, Oxidative Stress and Cardiovascular Aging
    Jun Ren; Fiscal Year: 2002
    ..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
  24. Early Experience and Adult Responses to Stress
    Brian Sanders; Fiscal Year: 2003
    ..Consistent with the mission of the AREA program, this project will provide a significant training and educational opportunity for undergraduate students. ..
  25. Calcium for Prevention of Postpartum Depression
    Daniel Hatton; Fiscal Year: 2004
    ..A significantly smaller proportion in the calcium group will be taken as evidence in support of the hypothesis. Positive results from this trial will provide a strong foundation for a multicenter intervention trial. ..
  26. Role of Acetaldehyde in Alcoholic Cardiomyopathy
    Jun Ren; Fiscal Year: 2008
    ..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
  27. Mechanisms of peripheral vascular anesthetic sensitivity
    THOMAS STEKIEL; Fiscal Year: 2008
    ..Additionally, this model also greatly facilitates development of congenic sub strains (partial chromosomal substitutions) for use in subsequent genetic mapping studies. ..
  28. Particulate Matter Exposure: Cardiovascular Mechanisms
    Chao Yin Chen; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  29. Psychiatric Genetics and Family Studies: Robust Methods
    Susan E Hodge; Fiscal Year: 2010
    ..Relevance: This work will contribute to public health by developing improved methods for identifying genes and understanding the genetics of common, complex diseases, including, but not limited to, psychiatric diseases. ..
  30. FUNCTIONAL GENOMICS OF ARTERIAL THROMBOSIS
    Myriam Fornage; Fiscal Year: 2004
    ..This collaborative effort is novel for its ability to translate unique animal model research findings to the human condition. ..
  31. Mechanisms of cardiovascular dysfunction in diabetes
    Csaba Szabo; Fiscal Year: 2005
    ..The final aim of the study is to investigate the activation of PARP in human microvasculature, and to correlate the degree of PARP activation with the degree of endothelial dysfunction in humans. ..
  32. Linage and Segregation in Complex Genetic Diseases
    SUSAN HODGE; Fiscal Year: 2007
    ..The project will also be flexible and will move rapidly to address new and pressing problems as they arise during the grant period, as this investigator has done successfully in the past. ..
  33. The Renin-Angiotensin II System in Cardiovascular Remodeling
    KATHLEEN BERECEK; Fiscal Year: 2007
    ..These studies will allow us to identify new targets for pharmacological intervention to prevent adverse cardiovascular remodeling in hypertension. ..
  34. MECHANISMS OF NEURODEGENERATION AND REGENERATION IN POST-STROKE SURVIVORS
    Raj Kalaria; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  35. Non-linear regulation of the renal circulation
    DONALD MARSH; Fiscal Year: 2007
    ..The revised proposal answers questions raised in the first review, and presents new results from simulations of coupled cortical and medullary nephrons. ..
  36. Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical Atherosclerosis
    Myriam Fornage; Fiscal Year: 2010
    ....
  37. Mechanisms of Arrhythmia Suppression by Exercise Traini*
    HEIDI LUJAN; Fiscal Year: 2005
    ..This experience will provide for me the research skill to develop into an independent investigator and the scientific foundation to obtain external funds at the national level. ..
  38. Peroxynitrate neutralizing agents for stroke therapy
    Csaba Szabo; Fiscal Year: 2003
    ....
  39. PHARMACOLOGIC PROBES IN NEURALLY-MEDIATED SYNCOPE
    Italo Biaggioni; Fiscal Year: 2003
    ..These studies will be directly applicable to the evaluation and treatment of patients with these incapacitating disorders. ..
  40. REGULATION OF RENAL FUNCTION AND BP BY THROMBOXANE
    CHRISTOPHER WILCOX; Fiscal Year: 2002
    ....
  41. ENDOTHELIAL CONTROL OF ARTERIOLAR TONE IN HYPERTENSION
    Akos Koller; Fiscal Year: 2004
    ....
  42. Gene-Environment Interactions and Stroke Susceptibility
    Myriam Fornage; Fiscal Year: 2004
    ..We will also identify and characterize DNA variation in a panel of selected stroke-candidate human genes and test whether variation in these genes is associated with risk of developing a stroke in the ARIC sample. ..
  43. Ultrapotent PARS inhibitor for CNS trauma
    Csaba Szabo; Fiscal Year: 2003
    ..Estimated worldwide revenues after market entry and maturation (ca. 4 years after FDA approval)=$750 million (annual). ..
  44. Myicardial injury: role of poly (ADP-ribose) synthetase
    Csaba Szabo; Fiscal Year: 2005
    ..Further, based on exciting preliminary data, the final, fifth aim is focusing in establishing the role of PARS in myocardial preconditioning. ..
  45. Identification of Novel Candidate Salt-Sensitivity Genes
    Robert Danziger; Fiscal Year: 2005
    ..This is a first step in the goal of developing novel and customized therapeutic approaches to hypertension based on genetics. ..
  46. Proteome Mapping of Heart Failure in Aging
    MARVIN BOLUYT; Fiscal Year: 2005
    ..Identification of proteins involved in aldosterone signaling will lead to the development of new hypotheses for future grant proposals addressing their roles in the development of heart failure in the elderly. ..
  47. TNF Alters Renal Tubular Function in Diabetes
    Frank Gesek; Fiscal Year: 2005
    ..Complementary techniques are used to examine alterations in vivo and at the cellular level. Our studies provide insights into the earliest changes that occur in DT due to the cytokine TNF. ..
  48. Ethanol Effects of SR Ca2+ Release in Cardiac Myocytes
    J Wasserstrom; Fiscal Year: 2005
    ....
  49. Cotinine for Cognitive Impairment in Neurological and Neuropsychiatric Disorders
    Alvin V Terry; Fiscal Year: 2010
    ..The partly translational design of the study will provide results leading to eventual clinical trials with cotinine or a relevant analog. ..
  50. Poly(ADP-ribose) synthetase inhibition and diabetes
    Csaba Szabo; Fiscal Year: 2004
    ....
  51. OPIOIDS AND CENTRAL NEURAL REGULATION OF RENAL FUNCTION
    DANIEL KAPUSTA; Fiscal Year: 2003
    ..In summary, an RCDA will greatly enhance my research productivity and scientific career. ..
  52. Neuroscience Center for Biomedical Research Excellence
    Francis W Flynn; Fiscal Year: 2010
    ....
  53. Genetic Analysis of Renal Disease in SHR and Dahl S Rats
    Michael Garrett; Fiscal Year: 2003
    ..These congenic strains are required for later fine genetic mapping and ultimate gene identification. ..
  54. KALLISTATIN IN HYPERTENSION
    Julie Chao; Fiscal Year: 2008
    ..abstract_text> ..
  55. Cerebrovascular mechanisms of ischemic injury in diabetes
    Adviye Ergul; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  56. GENETICS OF HEART AND KIDNEY DAMAGE IN HYPERTENSION
    Christian Deschepper; Fiscal Year: 2004
    ..abstract_text> ..
  57. Stretch-Induced Podocyte Injury
    Raghu Durvasula; Fiscal Year: 2007
    ..abstract_text> ..
  58. Decoupling Dynamics of the Autonomic Nervous System
    Ki Chon; Fiscal Year: 2005
    ..abstract_text> ..
  59. Cardio-renal actions of novel nociceptin analogues
    DANIEL KAPUSTA; Fiscal Year: 2008
    ..It is anticipated that work in this area will provide new strategies for the treatment of different pathological states associated with fluid retention and/or hyponatremia/hypokalemia. ..