inbred lew rats

Summary

Top Publications

  1. ncbi Gene expression profiling of bone marrow stromal cells from juvenile, adult, aged and osteoporotic rats: with an emphasis on osteoporosis
    Yin Xiao
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Bone 40:700-15. 2007
  2. ncbi The immunosuppressant FK506 activates capsaicin- and bradykinin-sensitive DRG neurons and cutaneous C-fibers
    Emiko Senba
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Neurosci Res 50:257-62. 2004
  3. pmc Prevention of mammary carcinogenesis by short-term estrogen and progestin treatments
    Lakshmanaswamy Rajkumar
    Department of Molecular and Cell Biology and The Cancer Research Laboratory, University of California, Berkeley, California, USA
    Breast Cancer Res 6:R31-7. 2004
  4. ncbi Islet cell engraftment and control of diabetes in rats after transplantation of pig pancreatic anlagen
    Sharon A Rogers
    Renal Division, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 286:E502-9. 2004
  5. ncbi Ocular transfer of retinal glial cells transduced ex vivo with adenovirus expressing viral IL-10 or CTLA4-Ig inhibits experimental autoimmune uveoretinitis
    C Verwaerde
    UMR CNRS 8527, Cellular Immunopathology of Infectious Diseases, Lille, France
    Gene Ther 10:1970-81. 2003
  6. ncbi Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    Y Y Kong
    Amgen Institute, Toronto, Ontario, Canada
    Nature 402:304-9. 1999
  7. ncbi Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat
    Zsuzsanna Helyes
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7643 Pecs, Szigeti u 12, Hungary
    Arthritis Rheum 50:1677-85. 2004
  8. ncbi Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion
    Thomas R Bernik
    Division of Vascular Surgery, North Shore University, 300 Community Drive, Manhasset, NY 11030, USA
    J Vasc Surg 36:1231-6. 2002
  9. ncbi Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations
    P G McMenamin
    Department of Anatomy and Human Biology, University of Western Australia, Nedlands
    J Comp Neurol 405:553-62. 1999
  10. pmc Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists
    Fred Luhder
    Institute for Virology and Immunobiology, University of Wurzburg, Versbacher Str 7, D 97078 Wurzburg, Germany
    J Exp Med 197:955-66. 2003

Research Grants

  1. GENETIC ANALYSIS OF HIP FRAGILITY
    Tatiana M Foroud; Fiscal Year: 2010
  2. A Novel Type of Dendritic Cell in Prevention of Glomerulonephritis
    YAHUAN LOU; Fiscal Year: 2013
  3. MURINE CRD: A MODEL OF CHRONIC PULMONARY IMFLAMMATION
    Gail Cassell; Fiscal Year: 1991
  4. GENETIC RESISTANCE TO EAE
    Elizabeth Blankenhorn; Fiscal Year: 2000
  5. ENCEPHALITOGENIC NATURE OF ALTERED BRAIN PREPARATION
    ROBERT SWANBORG; Fiscal Year: 2004
  6. Role of Innate Immunity in EAE
    ROBERT SWANBORG; Fiscal Year: 2007
  7. MOLECULAR TARGETS OF NITRIC OXIDE IN CARDIAC TRANSPLANTS
    GALEN PIEPER; Fiscal Year: 2004
  8. iNOS Posttranslational Regulation in Cardiac Rejection
    GALEN PIEPER; Fiscal Year: 2009
  9. CNS VIRAL INJURY AND VULNERABILITY TO OPIATE DRUG ABUSE
    Marylou Solbrig; Fiscal Year: 2002
  10. Viral neuropathology neuropeptides and epilepsy
    Marylou Solbrig; Fiscal Year: 2005

Detail Information

Publications243 found, 100 shown here

  1. ncbi Gene expression profiling of bone marrow stromal cells from juvenile, adult, aged and osteoporotic rats: with an emphasis on osteoporosis
    Yin Xiao
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
    Bone 40:700-15. 2007
    ..To better understand the possible relationships among genes, we fingerprinted genes in a rat model induced by ovariectomy to determine differences among osteoporotic, non-osteoporotic, aged and juvenile rats...
  2. ncbi The immunosuppressant FK506 activates capsaicin- and bradykinin-sensitive DRG neurons and cutaneous C-fibers
    Emiko Senba
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Neurosci Res 50:257-62. 2004
    ..These findings, taken together, indicate that FK506 application on inflamed skin may activate nociceptive C-fibers, which bear bradykinin receptors and capsaicin-sensitive heat transducer of TRP family, TRPV1...
  3. pmc Prevention of mammary carcinogenesis by short-term estrogen and progestin treatments
    Lakshmanaswamy Rajkumar
    Department of Molecular and Cell Biology and The Cancer Research Laboratory, University of California, Berkeley, California, USA
    Breast Cancer Res 6:R31-7. 2004
    ..This protective effect is observed universally among women of all ethnic groups. Parity in rats and mice also protects them against chemically induced mammary carcinogenesis...
  4. ncbi Islet cell engraftment and control of diabetes in rats after transplantation of pig pancreatic anlagen
    Sharon A Rogers
    Renal Division, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 286:E502-9. 2004
    ..Herein is described a novel means to effect the xenotransplantation of individual islet cells across a highly disparate barrier...
  5. ncbi Ocular transfer of retinal glial cells transduced ex vivo with adenovirus expressing viral IL-10 or CTLA4-Ig inhibits experimental autoimmune uveoretinitis
    C Verwaerde
    UMR CNRS 8527, Cellular Immunopathology of Infectious Diseases, Lille, France
    Gene Ther 10:1970-81. 2003
    ....
  6. ncbi Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    Y Y Kong
    Amgen Institute, Toronto, Ontario, Canada
    Nature 402:304-9. 1999
    ..These results show that both systemic and local T-cell activation can lead to OPGL production and subsequent bone loss, and they provide a novel paradigm for T cells as regulators of bone physiology...
  7. ncbi Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat
    Zsuzsanna Helyes
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7643 Pecs, Szigeti u 12, Hungary
    Arthritis Rheum 50:1677-85. 2004
    ..This study was undertaken to examine this systemic "sensocrine" function of neuronally derived somatostatin in chronic inflammation in the Freund's complete adjuvant (CFA)-induced arthritis model...
  8. ncbi Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion
    Thomas R Bernik
    Division of Vascular Surgery, North Shore University, 300 Community Drive, Manhasset, NY 11030, USA
    J Vasc Surg 36:1231-6. 2002
    ..VNS protects against endotoxin-induced shock by inhibiting hepatic and cardiac synthesis of TNF. Here, the effects of VNS on suppression of ischemia-reperfusion injury and cytokine release were studied in a rat model of aortic occlusion...
  9. ncbi Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations
    P G McMenamin
    Department of Anatomy and Human Biology, University of Western Australia, Nedlands
    J Comp Neurol 405:553-62. 1999
    ....
  10. pmc Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists
    Fred Luhder
    Institute for Virology and Immunobiology, University of Wurzburg, Versbacher Str 7, D 97078 Wurzburg, Germany
    J Exp Med 197:955-66. 2003
    ..Antibodies with this property may prove useful for the development of T cell stimulatory drugs...
  11. ncbi Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation
    L V Borovikova
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    Auton Neurosci 85:141-7. 2000
    ..These results now identify a previously unrecognized role of efferent vagus nerve activity in mediating the central action of an anti-inflammatory agent...
  12. pmc Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery
    C P Hofstetter
    Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 99:2199-204. 2002
    ..MSC constitute an easily accessible, easily expandable source of cells that may prove useful in the establishment of spinal cord repair protocols...
  13. ncbi Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
    Ingo Bartholomäus
    Max Planck Institute for Neurobiology, 82152 Martinsried, Germany
    Nature 462:94-8. 2009
    ..These contacts stimulated the effector T cells to produce pro-inflammatory mediators, and provided a trigger to tissue invasion and the formation of inflammatory infiltrations...
  14. ncbi Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology
    Timothy S Kern
    Medicine and Ophthalmology, 434 Biomedical Research Building, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Diabetes 56:373-9. 2007
    ..Local inhibition of inflammatory pathways in the eye offers a novel therapeutic approach toward inhibiting the development of lesions of diabetic retinopathy...
  15. ncbi Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cells
    E H Javazon
    Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Stem Cells 19:219-25. 2001
    ..The rat mMSCs differed from human mMSCs in that they regenerated RS cells in culture. Also, after low-density plating, colonies of rMSCs expanded into confluent cultures, whereas colonies of hMSCs did not...
  16. ncbi Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis
    A Flügel
    Max Planck Institute of Neurobiology, Department of Neuroimmunology, 82152 Martinsried, 10098, Berlin, Germany
    Immunity 14:547-60. 2001
    ..Within the CNS, the effector cells are reactivated, with upregulated proinflammatory cytokines and downmodulated T cell receptor-associated structures, presumably reflecting autoantigen recognition in situ...
  17. ncbi Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes
    Josbert M Metselaar
    Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands
    Arthritis Rheum 48:2059-66. 2003
    ....
  18. ncbi The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
    Florence M Bareyre
    Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
    Nat Neurosci 7:269-77. 2004
    ..Hence, after incomplete spinal cord injury, spontaneous extensive remodeling occurs, based on axonal sprout formation and removal. Such remodeling may be crucial for rehabilitation in humans...
  19. pmc Pharmacological stimulation of the cholinergic antiinflammatory pathway
    Thomas R Bernik
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    J Exp Med 195:781-8. 2002
    ..Together, these results indicate that stimulation of the cholinergic antiinflammatory pathway by either pharmacological or electrical methods can attenuate the systemic inflammatory response to endotoxin-induced shock...
  20. ncbi Cu/Zn superoxide dismutase plays important role in immune response
    Moshe Marikovsky
    Department of Animal Sciences, Faculty of Agricultural, Food, and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
    J Immunol 170:2993-3001. 2003
    ....
  21. ncbi Large-dose ascorbic acid administration suppresses the development of arthritis in adjuvant-infected rats
    A Sakai
    Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Arch Orthop Trauma Surg 119:121-6. 1999
    ....
  22. ncbi Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB
    Ling Zheng
    Department of Pharmacology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Diabetes 53:2960-7. 2004
    ..Thus, PARP activation plays an important role in the diabetes-induced death of retinal capillary cells, at least in part via its regulation of NF-kappaB...
  23. ncbi Adipose-derived stem cells are an effective cell candidate for treatment of heart failure: an MR imaging study of rat hearts
    Lei Wang
    Institute for Biodiagnostics, National Research Council Canada, Winnipeg, Canada
    Am J Physiol Heart Circ Physiol 297:H1020-31. 2009
    ..Results of this study suggest that ASCs were able to improve cardiac function of infarcted rat hearts. Paracrine effect may be the mechanism underlying the improved cardiac function and increased capillary density...
  24. ncbi Paradigm to test a drug-induced aversion to ethanol
    E Garver
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Alcohol Alcohol 35:435-8. 2000
    ..This model should be of value in the testing of new agents that reduce aldehyde dehydrogenase levels for prolonged periods for their potential as an aversive treatment in alcoholism...
  25. ncbi Additive bone-protective effects of anabolic treatment when used in conjunction with RANKL and tumor necrosis factor inhibition in two rat arthritis models
    Georg Schett
    Amgen Inc, Thousand Oaks, California, and Medical University of Vienna, Vienna, Austria
    Arthritis Rheum 52:1604-11. 2005
    ..To investigate whether the bone-preserving effects of a RANKL antagonist or a tumor necrosis factor (TNF) antagonist could be further improved by the addition of a bone anabolic agent in inflammatory arthritis...
  26. ncbi Suppressive DNA vaccination in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis involves a T1-biased immune response
    Anna Lobell
    Neuroimmunology Unit, Center for Molecular Medicine, L8 04, Karolinska Hospital, 171 76 Stockholm, Sweden
    J Immunol 170:1806-13. 2003
    ..The enhanced IgG2b responses together with the requirement for CpG DNA motifs in the vaccine suggest a protective mechanism involving induction of a T1-biased immune response...
  27. ncbi Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats
    Akihisa Yamashita
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 168:450-7. 2002
    ..FGF-2 may prove to be a possible therapeutic target to treat subjects with RA...
  28. ncbi Differential regulation of metzincins in experimental chronic renal allograft rejection: potential markers and novel therapeutic targets
    C C Berthier
    Division of Nephrology Hypertension, Inselspital, University of Bern, Bern, Switzerland
    Kidney Int 69:358-68. 2006
    ..Thus, an altered pattern of metzincins may represent novel diagnostic markers and possibly may provide novel targets for future therapeutic interventions...
  29. ncbi Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators
    Maria Mamani-Matsuda
    Laboratory of Immunology and Parasitology, EA3677, Faculty of Pharmacy, Bordeaux 2 University, France
    Biochem Pharmacol 72:1304-10. 2006
    ..These data indicate that QU is a potential anti-inflammatory therapeutic and preventive agent targeting the inflammatory response of macrophages...
  30. ncbi Factors influencing isolation of functional pancreatic rat islets
    Bart J de Haan
    Transplantation Biology and Immunoendocrinology, Pathology and Laboratory Medicine, Section of Medical Biology, University of Groningen, Groningen, The Netherlands
    Pancreas 29:e15-22. 2004
    ..Our observations indicate that strain and weight of the rat donor, the source of bovine serum albumin, and the culture conditions of islets are pertinent factors in efficacious isolation of islets...
  31. ncbi Anti-ergotypic T cells in naïve rats
    Avishai Mimran
    Department of Immunology, The Weizmann Institute of Science, Herzel Street, Rehovot 76100, Israel
    J Autoimmun 24:191-201. 2005
    ..The existence of anti-ergotypic T cells in naive animals suggests that these cells might have a role in the regulation and maintenance of the immune system...
  32. pmc Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment
    I Rioja
    Rheumatoid Arthritis Disease Biology Department, GlaxoSmithKline Medicines Research Centre, Stevenage, UK
    Clin Exp Immunol 137:65-73. 2004
    ....
  33. ncbi Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
    Deborah A Young
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Rheum 56:1152-63. 2007
    ..In this study, the effects of blocking IL-21 were examined in 2 rodent models of rheumatoid arthritis (RA) to determine whether IL-21 contributes to their pathologic processes...
  34. ncbi Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies
    Jens Schmidt
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, D 97080, Wurzburg, Germany
    J Neuroimmunol 140:143-52. 2003
    ..We demonstrate preventive and therapeutic effects of a "superagonistic" mAb-mediated, TCR-independent CD28 stimulation in EAN, possibly with implications for therapy of autoimmune-inflammatory disorders...
  35. pmc Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor
    H Neumann
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, Am Klopferspitz 18 A, 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 95:5779-84. 1998
    ..Our data suggest that neurotrophins secreted by electrically active neurons control the antigen-presenting potential of microglia cells, and indicate that this effect is mediated partly via the p75 neurotrophin receptor...
  36. ncbi Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1
    Peter Olofsson
    Section for Medical Inflammation Research, Lund University, S 22184 Lund, Sweden
    Genomics 83:765-71. 2004
    ..Therefore, the LEW/Mol should be regarded as a recombinant inbred strain...
  37. pmc The PI3K-NF-kappaB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis
    Pnina Fishman
    Can Fite BioPharma Ltd, Kiryat Matalon, Petah Tikva, Israel
    Arthritis Res Ther 8:R33. 2006
    ..The finding that the A3AR expression level in the peripheral blood mononuclear cells and in the DLN reflects the receptor status in the remote inflammatory site suggests use of the A3AR as a follow-up biomarker...
  38. ncbi Local retention of soluble antigen by potential antigen-presenting cells in the anterior segment of the eye
    Serge Camelo
    School of Anatomy and Human Biology, The University of Western Australia, Crawley Perth, Western Australia 6009, Australia
    Invest Ophthalmol Vis Sci 44:5212-9. 2003
    ..To determine the capacity of bone marrow-derived cells in the anterior segment of the eye to capture a fluorescence-labeled antigen (Ag) injected into the anterior chamber (AC)...
  39. ncbi Activation of extracellular signal-regulated kinases in the sciatic nerves of rats with experimental autoimmune neuritis
    Meejung Ahn
    Department of Veterinary Medicine, Cheju National University, Aradong 1, Jeju 690 756, South Korea
    Neurosci Lett 372:57-61. 2004
    ..Specifically, the activation of ERK in the recovery phase of EAN paralysis seems to be related in the survival of Schwann cells...
  40. pmc Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy
    Roland Jahns
    Department of Pharmacology and Toxicology, Medizinische Poliklinik, University of Wuerzburg, Germany
    J Clin Invest 113:1419-29. 2004
    ..Although carried out in an experimental animal model, our findings should further encourage the development of therapeutic strategies that combat harmful anti-beta(1)-EC(II) in receptor Ab-positive DCM patients...
  41. pmc Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion
    Naoto Kawakami
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    J Exp Med 201:1805-14. 2005
    ..We propose that rapid penetration of the CNS parenchyma by numerous autoimmune effector T cells along with multiple autoantigen-presentation events are responsible for the fulminate development of clinical EAE...
  42. ncbi Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of ischemic rat hearts
    Ingo Kutschka
    Department of Cardiothoracic Surgery, Stanford University, School of Medicine, Stanford, California, USA
    Circulation 114:I167-73. 2006
    ..Cardiac cell transplantation is limited by poor graft viability. We aimed to enhance the survival of transplanted cardiomyoblasts using growth factor-supplemented collagen matrices...
  43. pmc Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis
    Claire E Walters
    Department of Cell Biology, Institute of Ophthalmology, and Neuroinflammation Group, University College London, London, United Kingdom
    J Immunol 168:4087-94. 2002
    ..These studies demonstrate, for the first time, the potential for pharmacologically targeting CNS EC signaling responses, and particularly endothelial Rho proteins, as a means of attenuating leukocyte recruitment to the CNS...
  44. ncbi RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis
    Marina Stolina
    Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, California 91320, USA
    J Bone Miner Res 20:1756-65. 2005
    ..Osteoprotegerin (OPG) treatment reversed local and systemic bone loss, suggesting that RANKL is both a marker and mediator of bone loss in arthritis...
  45. pmc Short-term exposure to pregnancy levels of estrogen prevents mammary carcinogenesis
    L Rajkumar
    Department of Molecular and Cell Biology and The Cancer Research Laboratory, University of California, 491 Life Sciences Addition, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 98:11755-9. 2001
    ....
  46. ncbi Presence of CpG DNA and the local cytokine milieu determine the efficacy of suppressive DNA vaccination in experimental autoimmune encephalomyelitis
    A Lobell
    Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
    J Immunol 163:4754-62. 1999
    ..We conclude that the presence of ISS and induction of a local T1 cytokine milieu is decisive for specific protective DNA vaccination in EAE...
  47. pmc A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1)
    A S Hansson
    Section for Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University, 22362 Lund, Sweden
    J Clin Invest 104:589-98. 1999
    ..Taken together, these results represent a novel model for RP: matrilin-1-induced RP. Our findings also suggest that different cartilage proteins are involved in pathogenic models of RP and RA...
  48. ncbi Expression of constitutive endothelial and inducible nitric oxide synthase in the sciatic nerve of Lewis rats with experimental autoimmune neuritis
    Yongduk Lee
    Department of Veterinary Medicine, Graduate School Brain Korea 21 Project, Cheju National University, 690 756, Republic of Korea
    J Neuroimmunol 126:78-85. 2002
    ....
  49. ncbi Interferon-beta directly influences monocyte infiltration into the central nervous system
    Sarah Floris
    Department of Molecular Cell Biology, VU Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Neuroimmunol 127:69-79. 2002
    ..These data indicate that IFN-beta exerts direct antiinflammatory effects on brain endothelial cells thereby contributing to reduced lesion formation as observed in MS patients...
  50. ncbi The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus
    S Lenzen
    Institute of Clinical Biochemistry, Hannover Medical School, Germany
    Diabetologia 44:1189-96. 2001
    ..It could prove to be a valuable new animal model for clarifying the mechanisms involved in the development of autoimmune diabetes...
  51. ncbi Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy
    Ling Zheng
    Department of Medicine and Ophthalmology, 434 Biomedical Research Building, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Diabetes 56:337-45. 2007
    ....
  52. ncbi Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases
    T Zhou
    Department of Medicine, The University of Alabama at Birmingham, 35294, USA
    Nat Med 5:42-8. 1999
    ..Thus, the use of agents such as bisindolylmaleimide VIII may be therapeutically useful for supporting more effective elimination of detrimental cells through enhancement of Fas-dependent apoptosis signaling...
  53. ncbi The role of perivascular and meningeal macrophages in experimental allergic encephalomyelitis
    Machteld M J Polfliet
    Department of Molecular Cell Biology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    J Neuroimmunol 122:1-8. 2002
    ..These observations indicate that PVM and MM play a role during the early stages of EAE development...
  54. ncbi Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester
    M Tacke
    Institute for Virology and Immunobiology, University of Wurzburg, Germany
    J Immunol 154:5121-7. 1995
    ....
  55. ncbi Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis
    H Okamoto
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Clin Exp Rheumatol 23:323-30. 2005
    ..Ligands for peroxisome proliferator-activated receptor (PPAR) -gamma have recently been reported to inhibit the development of RA. In this study, we investigated the role of PPARalpha in RA...
  56. ncbi Physical map and expression profile of genes of the telomeric class I gene region of the rat MHC
    S Ioannidu
    Division of Immunogenetics, University of Gottingen, Gottingen, Germany
    J Immunol 166:3957-65. 2001
    ..The data provide further molecular information on the MHC for analyzing disease susceptibility and underline the usefulness of the rat model...
  57. ncbi Cellular adhesion molecules in rat adjuvant arthritis
    M M Halloran
    Northwestern University Medical School, Chicago, Illinois 60611, USA
    Arthritis Rheum 39:810-9. 1996
    ..To examine adhesion molecule expression during the progression of inflammation in a rheumatoid arthritis model of adjuvant-induced arthritis (AIA) in rats...
  58. ncbi Induction of osteoarthritis in the rat by surgical tear of the meniscus: Inhibition of joint damage by a matrix metalloproteinase inhibitor
    M J Janusz
    Procter and Gamble Pharmaceuticals Inc, 8700 Mason Montgomery Rd, Mason, OH 45040, USA
    Osteoarthritis Cartilage 10:785-91. 2002
    ..Characterize a model of osteoarthritis (OA) induced by a surgically transecting the medial collateral ligament and meniscus. Evaluate the effectiveness of a matrix metalloproteinase (MMP) inhibitor in this model...
  59. ncbi Resveratrol ameliorates experimental autoimmune myocarditis
    Yuki Yoshida
    Department of Internal Medicine and Cardiology, Kitasato University School of Medicine, Sagamihara, Japan
    Circ J 71:397-404. 2007
    ..Myosin-induced autoimmune myocarditis of rats is a model of human dilated cardiomyopathy. Resveratrol is a natural polyphenol found in grapes and wine that is reported to have cardioprotective and immunomodulatory effects...
  60. ncbi Inhibition of the chemokine receptor CXCR2 prevents kidney graft function deterioration due to ischemia/reperfusion
    Daniela Cugini
    Transplant Research Center Chiara Cucchi de Alessandri e Gilberto Crespi Mario Negri Institute for Pharmacological Research, Villa Camozzi, Ranica, Bergamo, Italy
    Kidney Int 67:1753-61. 2005
    ..Ischemia/reperfusion (I/R) injury after organ transplantation is a major cause of delayed graft function. Following I/R, locally produced CXC chemokines attract and activate granulocytes, which in turn promote graft damage...
  61. ncbi Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653
    Masataka Nishikawa
    Osaka University Graduate School of Medicine, Osaka, Japan
    Arthritis Rheum 48:2670-81. 2003
    ..In this study we investigated the effect of FR167653 on collagen-induced arthritis (CIA)...
  62. ncbi Acute myocarditis in a rat model: late gadolinium enhancement with histopathological correlation
    Huedayi Korkusuz
    Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Eur Radiol 19:2672-8. 2009
    ..Thus we think the current animal model can provide the opportunity for further fundamental research into myocarditis...
  63. ncbi Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization
    Felix Mor
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 172:4618-23. 2004
    ..Thus, T cells can play a role in angiogenesis by delivering VEGF to inflammatory sites, and VEGF can augment proinflammatory T cell differentiation...
  64. pmc Cell therapy attenuates cardiac dysfunction post myocardial infarction: effect of timing, routes of injection and a fibrin scaffold
    Juliana S Nakamuta
    Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 4:e6005. 2009
    ....
  65. ncbi Selective lack of the C16:0 fatty acid isoform of sulfatide in pancreas of type II diabetic animal models
    Maria Blomqvist
    Institute of Clinical Neuroscience, Experimental Neuroscience Section, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital Molndal, Sweden
    APMIS 111:867-77. 2003
    ..Thus, it is hypothesized that the selection of sulfatide isomers in pancreas might be a genetic factor contributing to disease development in type II diabetic animal models...
  66. ncbi Acute rejection after rat renal transplantation leads to downregulation of NA+ and water channels in the collecting duct
    Ana Velic
    Universitatsklinikum Munster, Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Munster, Germany
    Am J Transplant 5:1276-85. 2005
    ..These acute downregulations of ENaC and AQP2 may be triggered to reduce energy consumption in the distal nephron to protect the kidney immediately after transplantation...
  67. ncbi Antigen from the anterior chamber of the eye travels in a soluble form to secondary lymphoid organs via lymphatic and vascular routes
    Serge Camelo
    School of Anatomy and Human Biology, The University of Western Australia, Crawley Perth
    Invest Ophthalmol Vis Sci 47:1039-46. 2006
    ..To determine the afferent pathways linking the anterior chamber (AC) of the eye to the secondary lymphoid organs...
  68. ncbi Peroxisome proliferator-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis associated with inhibition of self-sensitive T cells
    Zuyi Yuan
    Department of Cardiovascular Medicine, First Hospital of Xi an Jiaotong University, Shaanxi, China
    J Cardiovasc Pharmacol 43:868-75. 2004
    ..In the present study, we investigated the expression of PPAR-gamma and the effect of PPAR-gamma ligands on experimental autoimmune myocarditis (EAM)...
  69. ncbi A CCR1 antagonist prevents the development of experimental autoimmune myocarditis in association with T cell inactivation
    Hideki Futamatsu
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Mol Cell Cardiol 40:853-61. 2006
    ..The CCR1 antagonist reduced the severity of EAM by inhibiting cytokine expression and inducing T cell inactivation. Thus, the CCR1 antagonist may provide a novel therapeutic strategy treatment of myocarditis...
  70. ncbi C16:0 sulfatide inhibits insulin secretion in rat beta-cells by reducing the sensitivity of KATP channels to ATP inhibition
    Karsten Buschard
    Bartholin Instituttet, Rigshospitalet, 2100 Copenhagen, Denmark
    Diabetes 55:2826-34. 2006
    ..We conclude that a major mechanism by which the predominant sulfatide isoform in beta-cells, C16:0 sulfatide, inhibits glucose-induced insulin secretion is by reducing the K(ATP) channel sensitivity to the ATP block...
  71. ncbi Comparison of anti-arthritic properties of leflunomide with methotrexate and FK506: effect on T cell activation-induced inflammatory cytokine production in vitro and rat adjuvant-induced arthritis
    K Magari
    Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, 2 1 6, Kashima, Yodogawa ku, 532 8514, Osaka, Japan
    Inflamm Res 53:544-50. 2004
    ....
  72. ncbi Sulfatide controls insulin secretion by modulation of ATP-sensitive K(+)-channel activity and Ca(2+)-dependent exocytosis in rat pancreatic beta-cells
    Karsten Buschard
    Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark
    Diabetes 51:2514-21. 2002
    ..Our data suggest that sulfatide is important for the control of glucose-induced insulin secretion and that both an increase and a decrease in the sulfatide content have an impact on the secretory capacity of the individual beta-cells...
  73. ncbi In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals
    F Forrer
    Department of Nuclear Medicine, Erasmus MC Rotterdam, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 33:1214-7. 2006
    ..In vivo quantification of radiopharmaceuticals has great potential as a tool in developing new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole single-photon emission computed tomography (SPECT) in rats...
  74. ncbi Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis
    Mary Jo Turk
    Purdue University, West Lafayette, Indiana 47907, USA
    Arthritis Rheum 46:1947-55. 2002
    ..To determine whether overexpression of the high-affinity folate receptor (FR) on activated macrophages can be exploited to selectively target imaging agents to sites of inflammation in rats with adjuvant-induced arthritis (AIA)...
  75. pmc The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis
    Naoto Kawakami
    Department of Neuroimmunology, Max Planck Institute for Neurobiology, 82152 Martinsried, Germany
    J Exp Med 199:185-97. 2004
    ..Low-level reactivation of weakly pathogenic T cells was not due to anergy because these cells could be activated by specific antigen in situ as well as after isolation ex vivo...
  76. ncbi The regulatory C-terminal determinants within mycobacterial heat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications for the pathogenesis of autoimmune arthritis
    Malarvizhi Durai
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 173:181-8. 2004
    ..The identification of disease-regulating cryptic determinants in Ags implicated in arthritis provides a novel approach for immunotherapy of rheumatoid arthritis...
  77. ncbi Normalization of glucose post-transplantation of pig pancreatic anlagen into non-immunosuppressed diabetic rats depends on obtaining anlagen prior to embryonic day 35
    Sharon A Rogers
    Renal Division, Department of Medicine, Washington University School of Medicine, St Louis MO 63110, USA
    Transpl Immunol 14:67-75. 2005
    ....
  78. ncbi Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist
    Chia Huey Lin
    Institute for Virology and Immunobiology, University of Wurzburg, Versbacherstrasse 7, D 97078 Wurzburg, Germany
    Eur J Immunol 33:626-38. 2003
    ..These data suggest that CD28-driven activation of Treg cells may be highly effective in the treatment of inflammatory and autoimmune diseases...
  79. pmc Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis
    C Beeton
    Laboratoire d'Immunologie, , 13385 Marseille, France
    Proc Natl Acad Sci U S A 98:13942-7. 2001
    ..We conclude that selective targeting of Kv1.3, alone or with IKCa1, may provide an effective new mode of therapy for multiple sclerosis...
  80. pmc Enhanced gene transfer to arthritic joints using adeno-associated virus type 5: implications for intra-articular gene therapy
    J Adriaansen
    Division of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 64:1677-84. 2005
    ..Gene therapy of the joint has great potential as a new therapeutic approach for the treatment of rheumatoid arthritis (RA). The vector chosen is of crucial importance for clinical success...
  81. ncbi Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling
    Salman R Khetani
    Department of Bioengineering at the University of California San Diego, La Jolla, CA 92093 0412, USA
    Hepatology 40:545-54. 2004
    ..g., bioartificial liver devices). In conclusion, the functional genomic approach presented in this study may be utilized to investigate mechanisms of cell-cell interaction in a variety of tissues and disease states...
  82. ncbi A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities
    Lichuan Yang
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Exp Neurol 191:86-93. 2005
    ..Our data provide further evidence that STAZN is a neuroprotective free radical spin trap, and suggest that the development of new antioxidants will broaden our therapeutic strategies for neurodegenerative diseases...
  83. ncbi Long-term effects of bone marrow mononuclear cell transplantation on left ventricular function and remodeling in rats
    Shaoheng Zhang
    Department of Cardiology, the Third Hospital of Peking University, 49 North Garden Road, Hai Dian District, Beijing, 100083, China
    Life Sci 74:2853-64. 2004
    ....
  84. ncbi DNA fragments of the human 60-kDa heat shock protein (HSP60) vaccinate against adjuvant arthritis: identification of a regulatory HSP60 peptide
    Francisco J Quintana
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 171:3533-41. 2003
    ..These results show that regulatory mechanisms can be activated by immunization with relevant self-HSP60 epitopes...
  85. ncbi Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy
    Punniyakoti T Veeraveedu
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Eur J Pharmacol 581:121-31. 2008
    ....
  86. ncbi Quantitative analysis of survival of transplanted smooth muscle cells with real-time polymerase chain reaction
    Tamotsu Yasuda
    Division of Cardiovascular Surgery, Toronto General Research Institute, Toronto General Hospital, Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 129:904-11. 2005
    ..Cell transplantation improves heart function after myocardial infarction. This study investigated the survival of implanted cells in normal and infarcted myocardium...
  87. ncbi Microarray-based gene expression profiles of allograft rejection and immunosuppression in the rat heart transplantation model
    Laurie M Erickson
    Fujisawa Research Institute of America, Northwestern University Evanston Research Park, Evanston, Illinois 60201, USA
    Transplantation 76:582-8. 2003
    ....
  88. ncbi DNA microarray analysis of gene expression in iris and ciliary body of rat eyes with endotoxin-induced uveitis
    Kouichi Ohta
    Department of Ophthalmology, School of Medicine, Shinshu University, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Exp Eye Res 80:401-12. 2005
    ..Our data suggest that the immediate early genes, such as Jun B, play an important role in inducing the inflammatory-related genes in the ICB...
  89. ncbi Protective role of heme oxygenase-1 against endotoxin-induced uveitis in rats
    Kouichi Ohta
    Department of Ophthalmology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Exp Eye Res 77:665-73. 2003
    ..001). Hemin is effective in inducing HO-1 and in reducing the ocular inflammation induced by LPS probably by down-regulating NO and pro-inflammatory cytokine expression...
  90. ncbi Regulatory T cells in experimental allergic encephalomyelitis. III. Comparison of disease resistance in Lewis and Fischer 344 rats
    D Sun
    Department of Neurology and the Center for Neuroimmunology of the University of Alabama at Birmingham, 35294, USA
    Eur J Immunol 29:1101-6. 1999
    ..However, the frequency of RTC that functionally inhibit MBP-reactive T cells is greater in F344 rats...
  91. ncbi Renal transplantation modulates expression and function of receptors and transporters of rat proximal tubules
    Ana Velic
    Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, Domagkstrasse 3a, D 48149 Munster, Germany
    J Am Soc Nephrol 15:967-77. 2004
    ..The local renin-angiotensin-system is apparently not altered. Downregulation of NHE-3 may be a protective mechanism occurring in the graft...
  92. pmc Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis
    Inmaculada Rioja
    Rheumatoid Arthritis Disease Biology Department, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK
    Arthritis Res Ther 7:R101-17. 2005
    ..These findings improve our understanding of the molecular events that underlie the pathology in this animal model, which is potentially a valuable comparator to human rheumatoid arthritis (RA)...
  93. ncbi Protective DNA vaccination against experimental autoimmune encephalomyelitis is associated with induction of IFNbeta
    Judit Wefer
    Applied Immunology Group, Karolinska Institutet Center for Molecular Medicine L8 04 Karolinska Hospital 171 76, Stockholm, Sweden
    J Neuroimmunol 149:66-76. 2004
    ..We suggest that the underlying mechanism of DNA vaccination is associated with immunomodulation exerted by induced IFNbeta...
  94. ncbi Inhibition of adjuvant-induced arthritis by DNA vaccination with the 70-kd or the 90-kd human heat-shock protein: immune cross-regulation with the 60-kd heat-shock protein
    Francisco J Quintana
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Arthritis Rheum 50:3712-20. 2004
    ..We have recently demonstrated that vaccination with human Hsp60 DNA inhibits AIA. The present study was undertaken to analyze the role of the T cell responses to self HSP molecules other than Hsp60 in the control of AIA...
  95. ncbi An intravital and confocal microscopic study of the distribution of intracameral antigen in the aqueous outflow pathways and limbus of the rat eye
    Serge Camelo
    School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Perth 6009, Western Australia
    Exp Eye Res 79:455-64. 2004
    ..In conclusion our data reveal that the majority of intracamerally injected soluble Ag retained in the eye is taken up by resident macrophages not only in the iris but in all tissues lining the AC of the eye...
  96. ncbi Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium
    Daxin Chen
    Department of Immunology, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
    Am J Transplant 4:1958-63. 2004
    ..This genetic strategy could be applied in a clinically relevant species such as the pig...
  97. ncbi Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60
    Francisco J Quintana
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 169:3422-8. 2002
    ..Our results support a regulatory role for HSP60 autoreactivity in AA and demonstrate that this control mechanism can be activated by DNA vaccination with both HSP60 or HSP65...
  98. ncbi Protective role of NHE-3 inhibition in rat renal transplantation undergoing acute rejection
    Stefan Reuter
    Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, Munster, Germany
    Pflugers Arch 456:1075-84. 2008
    ..Observed NHE-I-dependent changes in electrolyte excretion, polyuria, and reduced protein reabsorption in the acute postoperative phase are predictors of favorable graft outcome in humans...
  99. ncbi Comparative anatomy of laboratory animal corneas with a new-generation high-resolution in vivo confocal microscope
    Antoine Labbe
    Department of Ophthalmology III, Quinze Vingts National Ophthalmology Hospital, Paris, France
    Curr Eye Res 31:501-9. 2006
    ..The aim of the current study was to compare the corneas of three commonly used laboratory animals with a new in vivo confocal microscope...
  100. ncbi Inhibition of interleukin-1 but not tumor necrosis factor suppresses neovascularization in rat models of corneal angiogenesis and adjuvant arthritis
    Angela Coxon
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Arthritis Rheum 46:2604-12. 2002
    ..To assess the capacities of the cytokine inhibitors interleukin-1 receptor antagonist (IL-1Ra; anakinra) and PEGylated soluble tumor necrosis factor receptor I (PEG sTNFRI; pegsunercept) to suppress neovascularization...
  101. ncbi Allogenic immune response promotes the accumulation of host-derived smooth muscle cells in transplant arteriosclerosis
    Piotr Religa
    Department of Surgical Sciences, Karolinska Hospital, SE 17176 Stockholm, Sweden
    Cardiovasc Res 65:535-45. 2005
    ..Here, the role of an allogenic immune response in the accumulation of host-derived SMCs in the neointima was explored...

Research Grants68

  1. GENETIC ANALYSIS OF HIP FRAGILITY
    Tatiana M Foroud; Fiscal Year: 2010
    ..Our goal is to find genetic causes for bone weakening conditions like osteoporosis so better treatments can be developed. ..
  2. A Novel Type of Dendritic Cell in Prevention of Glomerulonephritis
    YAHUAN LOU; Fiscal Year: 2013
    ..Accomplishment of those aims will not only reveal a unique immune tolerance mechanism occurring in the target organ, but also provide a working model for development of cell-based immunotherapy for autoimmune GN. ..
  3. MURINE CRD: A MODEL OF CHRONIC PULMONARY IMFLAMMATION
    Gail Cassell; Fiscal Year: 1991
    ....
  4. GENETIC RESISTANCE TO EAE
    Elizabeth Blankenhorn; Fiscal Year: 2000
    ....
  5. ENCEPHALITOGENIC NATURE OF ALTERED BRAIN PREPARATION
    ROBERT SWANBORG; Fiscal Year: 2004
    ..Our objective is to ascertain how the activation of autoreactive encephalitogenic T cells is controlled, and how they evade immunological homeostasis to become activated and elicit autoimmune disease. ..
  6. Role of Innate Immunity in EAE
    ROBERT SWANBORG; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. MOLECULAR TARGETS OF NITRIC OXIDE IN CARDIAC TRANSPLANTS
    GALEN PIEPER; Fiscal Year: 2004
    ..These studies will provide a novel mechanism to explain the pathogenesis of dyskinesis and graft failure during cardiac transplant rejection. ..
  8. iNOS Posttranslational Regulation in Cardiac Rejection
    GALEN PIEPER; Fiscal Year: 2009
    ..A better understanding of this molecular process may lead to better strategies to prevent injury cardiac cells in these patients. ..
  9. CNS VIRAL INJURY AND VULNERABILITY TO OPIATE DRUG ABUSE
    Marylou Solbrig; Fiscal Year: 2002
    ..At the conclusion of the grant period, the requisite skills in behavioral pharmacology, neuropharmacology and molecular biology for continued work in the study and treatment of drug addiction will have been acquired by the candidate. ..
  10. Viral neuropathology neuropeptides and epilepsy
    Marylou Solbrig; Fiscal Year: 2005
    ....
  11. Estrogen, ACE2 and Salt-Sensitivity
    Mark Chappell; Fiscal Year: 2008
    ..Lewis strain. ..
  12. Robotics Extraction System/HPLC for Shared Resource Lab
    Mark Chappell; Fiscal Year: 2005
    ..abstract_text> ..
  13. Mechanism of Actions of Multitasking of Statins in AD
    Inderjit Singh; Fiscal Year: 2006
    ..abstract_text> ..
  14. Dopaminergic Mechanisms of Opioid Immunomodulation
    Timothy Saurer; Fiscal Year: 2006
    ..Collectively, the proposed studies will provide innovative and important new data regarding the neural mechanisms underlying immunomodulation by opioid drugs. ..
  15. Recombinant T-cell Receptor Ligands for Treatment of Uveitis
    Grazyna Adamus; Fiscal Year: 2006
    ..To determine an effective treatment regimen for clinical rat AAU using RTLs. 2. To determine the abilities of RTLs to inhibit recurrent anterior and posterior uveitis in Lewis rats. [unreadable] [unreadable] [unreadable] [unreadable]..
  16. Age, ethanol, and strain effects on the behavioral pharmacology of cannabinoids
    BRETT GINSBURG; Fiscal Year: 2008
    ..This project will help us understand how aging, exposure to ethanol, and perhaps genetic disposition change the behavioral response to these drugs. [unreadable] [unreadable] [unreadable]..
  17. Models for examining selective effects of pharmacotherapy on reinforced behaviors
    BRETT GINSBURG; Fiscal Year: 2008
    ..This project will clarify important factors involved in studies of alcohol effects and potential medications for alcoholics. [unreadable] [unreadable] [unreadable]..
  18. Structure/Function of Peroxisomes in Neuroinflammation
    Inderjit Singh; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  19. IMMUNOLOGICAL MECHANISM OF INFLAMMATION IN UVEITIS & EAE
    Grazyna Adamus; Fiscal Year: 2001
    ..3) Examine the role of cytokines and chemokines in the recruitment of cell to the eye in primary and recurrent uveitis associated with EAE after immunization of Lewis rats with MBP. ..
  20. Immunoregulation in Cyclosporine-Induced Autoimmunity
    Allan Hess; Fiscal Year: 2003
    ..This unique model and the proposed studies will provide novel insights into systemic control of autoaggression. ..
  21. INVARIANT CHAIN BASED VACCINE STRATEGIES
    Allan Hess; Fiscal Year: 2003
    ..These studies will identify novel strategies to enhance the immunogenicity of tumor peptides that may be broadly applicable to many different types of cancer. ..
  22. MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY
    Grazyna Adamus; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  23. Viral vector-based RNAi therapy for Alexander Disease
    Daniel Bonthius; Fiscal Year: 2008
    ..The disease is due to an abnormal gene. This research aims to develop a form of gene therapy to prevent and reverse the brain dysfunction of Alexander Disease. [unreadable] [unreadable] [unreadable]..
  24. Innate Immune Protection Against HIV-1 by Reproductive Tract Epithelial Cells
    Charles Wira; Fiscal Year: 2007
    ..These studies should provide the basis of knowledge essential for the development of more effective microbicides, therapeutic interventions, ..
  25. The role of costimulatory molecules in uveitis
    Hui Shao; Fiscal Year: 2011
    ..These studies should provide insights into the pathogenic mechanism leading to disease progression and help in the development of supplementary therapies for this devastating disease. ..
  26. Effects of abused drugs and genetics on impulsive choice
    Karen Anderson; Fiscal Year: 2007
    ..g., sharing needles that may result in the spread of HIV/AIDS. [unreadable] [unreadable] [unreadable]..
  27. Angiogenesis and Cardiac Growth as Heart Failure Therapy
    Y Woo; Fiscal Year: 2008
    ..The candidate's institution, sponsor, and chairman provide a uniquely supportive, high-caliber, educationally stimulating environment highly conducive to the achievement of these goals. ..
  28. BEHAVIORAL FACTORS IN HEROIN'S EFFECT ON NITRIC OXIDE
    DONALD LYSLE; Fiscal Year: 2007
    ..Collectively, the characterization of heroin-induced modulation of inducible nitric oxide in bacterial injections models provides a greater understanding of how opioids impact the immune system and health. ..
  29. Regulation of the Ocular Immune Response by Retinal Pigment Epithelium
    Hui Shao; Fiscal Year: 2007
    ..The results of our studies will provide new insights into the pathogenesis of uveitis. [unreadable] [unreadable] [unreadable]..
  30. IMMUNE RESPONSES IN PATIENTS WITH GBS AND CIDP
    AMJAD ILYAS; Fiscal Year: 2002
    ..Early and serial serum specimens from GBS and CIDP patients will be examined to see whether autoantibody titers correlate with disease severity. ..
  31. FETAL ALCOHOL EXPOSURE--NEUROIMMUNE INTERACTIONS
    Anna Taylor; Fiscal Year: 2001
    ....
  32. MACROPHAGE HETEROGENEITY AFTER SPINAL CORD INJURY
    Phillip Popovich; Fiscal Year: 2008
    ..In this way, CNS macrophages could be used as vehicles for drug delivery. [unreadable] [unreadable]..
  33. BORNA DISEASE VIRUS AND NEUROPSYCHIATRIC DISEASE
    WALTER LIPKIN; Fiscal Year: 2002
    ..This study will be the first to collect and process human sera and PBMC samples in clinical laboratories with no history of BDV research and dispense aliquots to a central laboratory for randomized, blinded analysis. ..
  34. HSP27 in Kidney Epithelial to Mesenchymal Transformation
    Arjang Djamali; Fiscal Year: 2008
    ..Overexpression of HSP27 will be obtained by recombinant virus-mediated HSP27 gene transfer. This proposal would allow us to determine whether HSP27 overexpression can prevent/delay EMT. ..
  35. Is ethanol rewarding or aversive?
    Chuang Liu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. MOLECULAR ANALYSIS OF A NEUROTROPIC AGENT--BORNA VIRUS
    WALTER LIPKIN; Fiscal Year: 2002
    ....
  37. Pathogen Discovery in Chronic Lung Disease by Mass Tag PCR and Microarray
    W Ian Lipkin; Fiscal Year: 2009
    ....
  38. Neural Mechanisms of Heroin-induced Conditioned Immunomodulation
    DONALD T contact LYSLE; Fiscal Year: 2010
    ..abstract_text> ..
  39. SELF-DETERMINANTS & INDIRECTION OF ANTI-SELF IMMUNITY
    KAMAL MOUDGIL; Fiscal Year: 2001
    ..They believe that such predetermined, experimentally programmed control of the display hierarchy of cryptic self determinants would pave the way for novel immunotherapeutic strategies for prevention and treatment of cancer. ..
  40. Feline Model of Neuropathy associated with anti-MAG/SGPG antibodies
    AMJAD ILYAS; Fiscal Year: 2007
    ..These studies may lead to the development of a feline model of anti-MAG/SGPG neuropathy that closely resembles the human disorder [unreadable] [unreadable] [unreadable] [unreadable]..
  41. Repopulation of Liver Allografts by Recipients
    Zhaoli Sun; Fiscal Year: 2007
    ..Our studies may provide new insights into the mechanisms which promote tolerance and regeneration after liver transplantation and will provide the basis for the development of novel therapies. [unreadable] [unreadable] [unreadable]..
  42. PROFILING SYNOVIAL VASCULATURE IN ARTHRITIS-PRONE RATS
    KAMAL MOUDGIL; Fiscal Year: 2005
    ..abstract_text> ..
  43. A Staged Strategy for Virus Identification and Discovery
    W Ian Lipkin; Fiscal Year: 2005
    ..Our initial focus will be two chronic diseases where specific viral taxa are associated and potentially implicated in pathogenesis: bronchioalveolar cell carcinoma and amyotrophic lateral sclerosis. ..
  44. NEUROTERATOGENIC MECHANISM OF LCM VIRUS INFECTION
    Daniel Bonthius; Fiscal Year: 2005
    ..The importance of a-DG in influencing the tropism and infectivity of LCMV will be examined by blocking alpha-DG with an antibody prior to exposure of brain slices to LCMV. ..
  45. Mass Tag PCR Detection of Respiratory Pathogens
    W Ian Lipkin; Fiscal Year: 2004
    ..abstract_text> ..
  46. A Staged Strategy for Virus Identification and Discovery
    WALTER LIPKIN; Fiscal Year: 2004
    ..Consistent with aims proposed in AI51292, our initial clinical application will be to analyze enteroviral serotypes implicated in human disease in North America. ..
  47. ATHEROGENESIS AND THE BONE MARROW ANGIOTENSIN SYSTEM
    Carlos Ferrario; Fiscal Year: 2004
    ..The proposed research will uncover novel mechanisms of atherogenesis that may have significant impact in the development of new therapeutic modalities applicable to cardiovascular and blood vessel diseases. ..
  48. A DEVELOPMENTAL MODEL FOR AUTISM BASED ON CNS INFECTION
    WALTER LIPKIN; Fiscal Year: 2004
    ..4) Determine how opoptosis contributes to the neuropathology observed after neonatal infection. (5) Analyze regional changes in neurotransmitter systems following neonatal infection. ..
  49. Opioid-Induced Immune Alterations: Gender Differences
    DONALD LYSLE; Fiscal Year: 2006
    ..These studies have clinical importance and will influence the selection of opioids for patient care, as well as enhance our understanding of potential sex differences in the adverse consequences of opioid use and abuse. ..
  50. REGULATION OF AUTOIMMUNITY THROUGH EPITOPE SPREADING
    KAMAL MOUDGIL; Fiscal Year: 2006
    ..This in turn would contribute to developing novel therapeutic approaches for RA and other autoimmune diseases. [unreadable] [unreadable]..
  51. Mesenchymal Progenitors of Intragraft Fibroblasts
    GORDON WU; Fiscal Year: 2007
    ..Completion of this research project will have defined the FP of IF and determined the migratory mechanisms by which FP home to allografts during chronic rejection. ..
  52. DETERMINANTS OF OPIOID/IMMUNE INTERACTIONS
    DONALD LYSLE; Fiscal Year: 2003
    ..Collectively, the proposed experiments promise to advance our understanding of the health consequences of heroin and morphine, providing important information to guide clinical care and advance development of new therapeutic approaches. ..
  53. Modulation of Autoimmunity by Green Tea Polyphenols
    KAMAL MOUDGIL; Fiscal Year: 2006
    ..The results of this study would help in establishing a reliable scientific basis for the use of PGT in autoimmune arthritis, and in developing better therapeutic approaches for RA. ..
  54. OPIOID INDUCED ALTERATIONS OF IMMUNE STATUS
    DONALD LYSLE; Fiscal Year: 2006
    ..This integration will provide a unique and comprehensive understanding of the health consequences of opioid use. ..
  55. DENVER CARDIOVASCULAR HEALTH EDUCATION ALLIANCE, PHASE I
    Leslie Leinwand; Fiscal Year: 2004
    ..abstract_text> ..
  56. MECHANISM OF CIGARETTE SMOKE-INDUCED IMMUNOSUPPRESSION
    Mohan Sopori; Fiscal Year: 2003
    ..Additionally, the results may provide insight into the mechanism of T cell tolerance and neuroimmune interactions. ..
  57. Mechanisms of CMV latency in accelerated vascular disease
    Daniel N Streblow; Fiscal Year: 2010
    ..Does mutation of the RCMV genes expressed in the latently infected allografts alter virus-induced acceleration of disease? B. What is the function of RCMV genes expressed in latently infected allografts? ..
  58. Behavioral Economics in Closed Economies
    GREGORY MADDEN; Fiscal Year: 2003
    ..Correct predictions will support the behavioral economic account of relative reinforcer efficacy. Experiment 2 will assess the same predictions using drug (alcohol self-administration) and non-drug reinforcers. ..
  59. Cytoskeletal Modulation of Bone Cell Mechanosensitivity
    ALEXANDER ROBLING; Fiscal Year: 2006
    ..Insights into the mechanisms of mechanosensory loss and recovery hold potential in the public health arena for optimizing the positive effects of loading on bone mass, fragility, and fracture risk. ..
  60. THE ROLE OF LYMPHOCYTES IN CEREBRAL ISCHEMIC INJURY
    Kyra Becker; Fiscal Year: 2004
    ....
  61. Nicotine and Cognition in Parkinsonism
    Jay Schneider; Fiscal Year: 2008
    ..Information obtained from these studies will hopefully lead to more efficient design of nicotinic therapeutics for patients with a variety of cognitive disorders. ..
  62. Chronobiology of alcohol: animal models
    ALAN ROSENWASSER; Fiscal Year: 2006
    ..The results of these studies will contribute substantially to understanding both the causes and the consequences of sleep and circadian rhythm disruptions occurring in human alcoholics. ..
  63. Neuroprotective Role of Fetuin in Cerebral Ischemia
    Haichao Wang; Fiscal Year: 2008
    ..Answers to these questions will improve our understanding of the pathophysiology of ischemic neural injury, and identify novel therapeutic agents for the treatment of stroke and related disorders. ..
  64. NMR Detection of Gene Expression
    BRIAN ROMAN; Fiscal Year: 2007
    ..This system will also be able to evaluate therapeutic regimens as the activity of the biosensor (CK) will modulate with the disease process. ..
  65. MECHANICS OF ACUTE LUNG INJURY
    Jason Bates; Fiscal Year: 2009
    ..The results of our studies are expected to lead to the design of physiologically-based lung recruitment strategies that can be tailored to the individual patient with ALI. This will set the stage for future clinical trials. ..
  66. Role of T Cells in Experimental Spondyloarthropathy
    JOEL TAUROG; Fiscal Year: 2002
    ..These experiments will examine directly the effect of Tap2a on the B27 peptide repertoire and on disease manifestations. ..