- Gene expression profiling of bone marrow stromal cells from juvenile, adult, aged and osteoporotic rats: with an emphasis on osteoporosis
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
Bone 40:700-15. 2007
..To better understand the possible relationships among genes, we fingerprinted genes in a rat model induced by ovariectomy to determine differences among osteoporotic, non-osteoporotic, aged and juvenile rats...
- The immunosuppressant FK506 activates capsaicin- and bradykinin-sensitive DRG neurons and cutaneous C-fibers
Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
Neurosci Res 50:257-62. 2004
..These findings, taken together, indicate that FK506 application on inflamed skin may activate nociceptive C-fibers, which bear bradykinin receptors and capsaicin-sensitive heat transducer of TRP family, TRPV1...
- Prevention of mammary carcinogenesis by short-term estrogen and progestin treatments
Department of Molecular and Cell Biology and The Cancer Research Laboratory, University of California, Berkeley, California, USA
Breast Cancer Res 6:R31-7. 2004
..This protective effect is observed universally among women of all ethnic groups. Parity in rats and mice also protects them against chemically induced mammary carcinogenesis...
- Islet cell engraftment and control of diabetes in rats after transplantation of pig pancreatic anlagen
Sharon A Rogers
Renal Division, Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Am J Physiol Endocrinol Metab 286:E502-9. 2004
..Herein is described a novel means to effect the xenotransplantation of individual islet cells across a highly disparate barrier...
- Ocular transfer of retinal glial cells transduced ex vivo with adenovirus expressing viral IL-10 or CTLA4-Ig inhibits experimental autoimmune uveoretinitis
UMR CNRS 8527, Cellular Immunopathology of Infectious Diseases, Lille, France
Gene Ther 10:1970-81. 2003
- Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
Y Y Kong
Amgen Institute, Toronto, Ontario, Canada
Nature 402:304-9. 1999
..These results show that both systemic and local T-cell activation can lead to OPGL production and subsequent bone loss, and they provide a novel paradigm for T cells as regulators of bone physiology...
- Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, H 7643 Pecs, Szigeti u 12, Hungary
Arthritis Rheum 50:1677-85. 2004
..This study was undertaken to examine this systemic "sensocrine" function of neuronally derived somatostatin in chronic inflammation in the Freund's complete adjuvant (CFA)-induced arthritis model...
- Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion
Thomas R Bernik
Division of Vascular Surgery, North Shore University, 300 Community Drive, Manhasset, NY 11030, USA
J Vasc Surg 36:1231-6. 2002
..VNS protects against endotoxin-induced shock by inhibiting hepatic and cardiac synthesis of TNF. Here, the effects of VNS on suppression of ischemia-reperfusion injury and cytokine release were studied in a rat model of aortic occlusion...
- Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations
P G McMenamin
Department of Anatomy and Human Biology, University of Western Australia, Nedlands
J Comp Neurol 405:553-62. 1999
- Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists
Institute for Virology and Immunobiology, University of Wurzburg, Versbacher Str 7, D 97078 Wurzburg, Germany
J Exp Med 197:955-66. 2003
..Antibodies with this property may prove useful for the development of T cell stimulatory drugs...
- Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation
L V Borovikova
The Picower Institute for Medical Research, Manhasset, NY 11030, USA
Auton Neurosci 85:141-7. 2000
..These results now identify a previously unrecognized role of efferent vagus nerve activity in mediating the central action of an anti-inflammatory agent...
- Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery
C P Hofstetter
Department of Neuroscience, Karolinska Institutet, S 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 99:2199-204. 2002
..MSC constitute an easily accessible, easily expandable source of cells that may prove useful in the establishment of spinal cord repair protocols...
- Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
Max Planck Institute for Neurobiology, 82152 Martinsried, Germany
Nature 462:94-8. 2009
..These contacts stimulated the effector T cells to produce pro-inflammatory mediators, and provided a trigger to tissue invasion and the formation of inflammatory infiltrations...
- Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology
Timothy S Kern
Medicine and Ophthalmology, 434 Biomedical Research Building, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
Diabetes 56:373-9. 2007
..Local inhibition of inflammatory pathways in the eye offers a novel therapeutic approach toward inhibiting the development of lesions of diabetic retinopathy...
- Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cells
E H Javazon
Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
Stem Cells 19:219-25. 2001
..The rat mMSCs differed from human mMSCs in that they regenerated RS cells in culture. Also, after low-density plating, colonies of rMSCs expanded into confluent cultures, whereas colonies of hMSCs did not...
- Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis
Max Planck Institute of Neurobiology, Department of Neuroimmunology, 82152 Martinsried, 10098, Berlin, Germany
Immunity 14:547-60. 2001
..Within the CNS, the effector cells are reactivated, with upregulated proinflammatory cytokines and downmodulated T cell receptor-associated structures, presumably reflecting autoantigen recognition in situ...
- Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes
Josbert M Metselaar
Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands
Arthritis Rheum 48:2059-66. 2003
- The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats
Florence M Bareyre
Department of Neuromorphology, Brain Research Institute, University of Zurich, Switzerland
Nat Neurosci 7:269-77. 2004
..Hence, after incomplete spinal cord injury, spontaneous extensive remodeling occurs, based on axonal sprout formation and removal. Such remodeling may be crucial for rehabilitation in humans...
- Pharmacological stimulation of the cholinergic antiinflammatory pathway
Thomas R Bernik
Laboratory of Biomedical Science, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
J Exp Med 195:781-8. 2002
..Together, these results indicate that stimulation of the cholinergic antiinflammatory pathway by either pharmacological or electrical methods can attenuate the systemic inflammatory response to endotoxin-induced shock...
- Cu/Zn superoxide dismutase plays important role in immune response
Department of Animal Sciences, Faculty of Agricultural, Food, and Environmental Quality Sciences, Hebrew University of Jerusalem, Rehovot, Israel
J Immunol 170:2993-3001. 2003
- Large-dose ascorbic acid administration suppresses the development of arthritis in adjuvant-infected rats
Department of Orthopaedic Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
Arch Orthop Trauma Surg 119:121-6. 1999
- Poly(ADP-ribose) polymerase is involved in the development of diabetic retinopathy via regulation of nuclear factor-kappaB
Department of Pharmacology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
Diabetes 53:2960-7. 2004
..Thus, PARP activation plays an important role in the diabetes-induced death of retinal capillary cells, at least in part via its regulation of NF-kappaB...
- Adipose-derived stem cells are an effective cell candidate for treatment of heart failure: an MR imaging study of rat hearts
Institute for Biodiagnostics, National Research Council Canada, Winnipeg, Canada
Am J Physiol Heart Circ Physiol 297:H1020-31. 2009
..Results of this study suggest that ASCs were able to improve cardiac function of infarcted rat hearts. Paracrine effect may be the mechanism underlying the improved cardiac function and increased capillary density...
- Paradigm to test a drug-induced aversion to ethanol
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Alcohol Alcohol 35:435-8. 2000
..This model should be of value in the testing of new agents that reduce aldehyde dehydrogenase levels for prolonged periods for their potential as an aversive treatment in alcoholism...
- Additive bone-protective effects of anabolic treatment when used in conjunction with RANKL and tumor necrosis factor inhibition in two rat arthritis models
Amgen Inc, Thousand Oaks, California, and Medical University of Vienna, Vienna, Austria
Arthritis Rheum 52:1604-11. 2005
..To investigate whether the bone-preserving effects of a RANKL antagonist or a tumor necrosis factor (TNF) antagonist could be further improved by the addition of a bone anabolic agent in inflammatory arthritis...
- Suppressive DNA vaccination in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis involves a T1-biased immune response
Neuroimmunology Unit, Center for Molecular Medicine, L8 04, Karolinska Hospital, 171 76 Stockholm, Sweden
J Immunol 170:1806-13. 2003
..The enhanced IgG2b responses together with the requirement for CpG DNA motifs in the vaccine suggest a protective mechanism involving induction of a T1-biased immune response...
- Fibroblast growth factor-2 determines severity of joint disease in adjuvant-induced arthritis in rats
Division of Pathophysiological and Experimental Pathology, Department of Pathology, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Immunol 168:450-7. 2002
..FGF-2 may prove to be a possible therapeutic target to treat subjects with RA...
- Differential regulation of metzincins in experimental chronic renal allograft rejection: potential markers and novel therapeutic targets
C C Berthier
Division of Nephrology Hypertension, Inselspital, University of Bern, Bern, Switzerland
Kidney Int 69:358-68. 2006
..Thus, an altered pattern of metzincins may represent novel diagnostic markers and possibly may provide novel targets for future therapeutic interventions...
- Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators
Laboratory of Immunology and Parasitology, EA3677, Faculty of Pharmacy, Bordeaux 2 University, France
Biochem Pharmacol 72:1304-10. 2006
..These data indicate that QU is a potential anti-inflammatory therapeutic and preventive agent targeting the inflammatory response of macrophages...
- Factors influencing isolation of functional pancreatic rat islets
Bart J de Haan
Transplantation Biology and Immunoendocrinology, Pathology and Laboratory Medicine, Section of Medical Biology, University of Groningen, Groningen, The Netherlands
Pancreas 29:e15-22. 2004
..Our observations indicate that strain and weight of the rat donor, the source of bovine serum albumin, and the culture conditions of islets are pertinent factors in efficacious isolation of islets...
- Anti-ergotypic T cells in naïve rats
Department of Immunology, The Weizmann Institute of Science, Herzel Street, Rehovot 76100, Israel
J Autoimmun 24:191-201. 2005
..The existence of anti-ergotypic T cells in naive animals suggests that these cells might have a role in the regulation and maintenance of the immune system...
- Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment
Rheumatoid Arthritis Disease Biology Department, GlaxoSmithKline Medicines Research Centre, Stevenage, UK
Clin Exp Immunol 137:65-73. 2004
- Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
Deborah A Young
Wyeth Research, Cambridge, Massachusetts 02140, USA
Arthritis Rheum 56:1152-63. 2007
..In this study, the effects of blocking IL-21 were examined in 2 rodent models of rheumatoid arthritis (RA) to determine whether IL-21 contributes to their pathologic processes...
- Treatment and prevention of experimental autoimmune neuritis with superagonistic CD28-specific monoclonal antibodies
Department of Neurology, University of Wurzburg, Josef Schneider Str 11, D 97080, Wurzburg, Germany
J Neuroimmunol 140:143-52. 2003
..We demonstrate preventive and therapeutic effects of a "superagonistic" mAb-mediated, TCR-independent CD28 stimulation in EAN, possibly with implications for therapy of autoimmune-inflammatory disorders...
- Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor
Department of Neuroimmunology, Max Planck Institute of Neurobiology, Am Klopferspitz 18 A, 82152 Martinsried, Germany
Proc Natl Acad Sci U S A 95:5779-84. 1998
..Our data suggest that neurotrophins secreted by electrically active neurons control the antigen-presenting potential of microglia cells, and indicate that this effect is mediated partly via the p75 neurotrophin receptor...
- Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1
Section for Medical Inflammation Research, Lund University, S 22184 Lund, Sweden
Genomics 83:765-71. 2004
..Therefore, the LEW/Mol should be regarded as a recombinant inbred strain...
- The PI3K-NF-kappaB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis
Can Fite BioPharma Ltd, Kiryat Matalon, Petah Tikva, Israel
Arthritis Res Ther 8:R33. 2006
..The finding that the A3AR expression level in the peripheral blood mononuclear cells and in the DLN reflects the receptor status in the remote inflammatory site suggests use of the A3AR as a follow-up biomarker...
- Local retention of soluble antigen by potential antigen-presenting cells in the anterior segment of the eye
School of Anatomy and Human Biology, The University of Western Australia, Crawley Perth, Western Australia 6009, Australia
Invest Ophthalmol Vis Sci 44:5212-9. 2003
..To determine the capacity of bone marrow-derived cells in the anterior segment of the eye to capture a fluorescence-labeled antigen (Ag) injected into the anterior chamber (AC)...
- Activation of extracellular signal-regulated kinases in the sciatic nerves of rats with experimental autoimmune neuritis
Department of Veterinary Medicine, Cheju National University, Aradong 1, Jeju 690 756, South Korea
Neurosci Lett 372:57-61. 2004
..Specifically, the activation of ERK in the recovery phase of EAN paralysis seems to be related in the survival of Schwann cells...
- Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy
Department of Pharmacology and Toxicology, Medizinische Poliklinik, University of Wuerzburg, Germany
J Clin Invest 113:1419-29. 2004
..Although carried out in an experimental animal model, our findings should further encourage the development of therapeutic strategies that combat harmful anti-beta(1)-EC(II) in receptor Ab-positive DCM patients...
- Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion
Department of Neuroimmunology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
J Exp Med 201:1805-14. 2005
..We propose that rapid penetration of the CNS parenchyma by numerous autoimmune effector T cells along with multiple autoantigen-presentation events are responsible for the fulminate development of clinical EAE...
- Collagen matrices enhance survival of transplanted cardiomyoblasts and contribute to functional improvement of ischemic rat hearts
Department of Cardiothoracic Surgery, Stanford University, School of Medicine, Stanford, California, USA
Circulation 114:I167-73. 2006
..Cardiac cell transplantation is limited by poor graft viability. We aimed to enhance the survival of transplanted cardiomyoblasts using growth factor-supplemented collagen matrices...
- Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis
Claire E Walters
Department of Cell Biology, Institute of Ophthalmology, and Neuroinflammation Group, University College London, London, United Kingdom
J Immunol 168:4087-94. 2002
..These studies demonstrate, for the first time, the potential for pharmacologically targeting CNS EC signaling responses, and particularly endothelial Rho proteins, as a means of attenuating leukocyte recruitment to the CNS...
- RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis
Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, California 91320, USA
J Bone Miner Res 20:1756-65. 2005
..Osteoprotegerin (OPG) treatment reversed local and systemic bone loss, suggesting that RANKL is both a marker and mediator of bone loss in arthritis...
- Short-term exposure to pregnancy levels of estrogen prevents mammary carcinogenesis
Department of Molecular and Cell Biology and The Cancer Research Laboratory, University of California, 491 Life Sciences Addition, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 98:11755-9. 2001
- Presence of CpG DNA and the local cytokine milieu determine the efficacy of suppressive DNA vaccination in experimental autoimmune encephalomyelitis
Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden
J Immunol 163:4754-62. 1999
..We conclude that the presence of ISS and induction of a local T1 cytokine milieu is decisive for specific protective DNA vaccination in EAE...
- A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1)
A S Hansson
Section for Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University, 22362 Lund, Sweden
J Clin Invest 104:589-98. 1999
..Taken together, these results represent a novel model for RP: matrilin-1-induced RP. Our findings also suggest that different cartilage proteins are involved in pathogenic models of RP and RA...
- Expression of constitutive endothelial and inducible nitric oxide synthase in the sciatic nerve of Lewis rats with experimental autoimmune neuritis
Department of Veterinary Medicine, Graduate School Brain Korea 21 Project, Cheju National University, 690 756, Republic of Korea
J Neuroimmunol 126:78-85. 2002
- Interferon-beta directly influences monocyte infiltration into the central nervous system
Department of Molecular Cell Biology, VU Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
J Neuroimmunol 127:69-79. 2002
..These data indicate that IFN-beta exerts direct antiinflammatory effects on brain endothelial cells thereby contributing to reduced lesion formation as observed in MS patients...
- The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus
Institute of Clinical Biochemistry, Hannover Medical School, Germany
Diabetologia 44:1189-96. 2001
..It could prove to be a valuable new animal model for clarifying the mechanisms involved in the development of autoimmune diabetes...
- Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy
Department of Medicine and Ophthalmology, 434 Biomedical Research Building, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Diabetes 56:337-45. 2007
- Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases
Department of Medicine, The University of Alabama at Birmingham, 35294, USA
Nat Med 5:42-8. 1999
..Thus, the use of agents such as bisindolylmaleimide VIII may be therapeutically useful for supporting more effective elimination of detrimental cells through enhancement of Fas-dependent apoptosis signaling...
- The role of perivascular and meningeal macrophages in experimental allergic encephalomyelitis
Machteld M J Polfliet
Department of Molecular Cell Biology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
J Neuroimmunol 122:1-8. 2002
..These observations indicate that PVM and MM play a role during the early stages of EAE development...
- Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester
Institute for Virology and Immunobiology, University of Wurzburg, Germany
J Immunol 154:5121-7. 1995
- Inhibition of NF-kappaB signaling by fenofibrate, a peroxisome proliferator-activated receptor-alpha ligand, presents a therapeutic strategy for rheumatoid arthritis
Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
Clin Exp Rheumatol 23:323-30. 2005
..Ligands for peroxisome proliferator-activated receptor (PPAR) -gamma have recently been reported to inhibit the development of RA. In this study, we investigated the role of PPARalpha in RA...
- Physical map and expression profile of genes of the telomeric class I gene region of the rat MHC
Division of Immunogenetics, University of Gottingen, Gottingen, Germany
J Immunol 166:3957-65. 2001
..The data provide further molecular information on the MHC for analyzing disease susceptibility and underline the usefulness of the rat model...
- Cellular adhesion molecules in rat adjuvant arthritis
M M Halloran
Northwestern University Medical School, Chicago, Illinois 60611, USA
Arthritis Rheum 39:810-9. 1996
..To examine adhesion molecule expression during the progression of inflammation in a rheumatoid arthritis model of adjuvant-induced arthritis (AIA) in rats...
- Induction of osteoarthritis in the rat by surgical tear of the meniscus: Inhibition of joint damage by a matrix metalloproteinase inhibitor
M J Janusz
Procter and Gamble Pharmaceuticals Inc, 8700 Mason Montgomery Rd, Mason, OH 45040, USA
Osteoarthritis Cartilage 10:785-91. 2002
..Characterize a model of osteoarthritis (OA) induced by a surgically transecting the medial collateral ligament and meniscus. Evaluate the effectiveness of a matrix metalloproteinase (MMP) inhibitor in this model...
- Resveratrol ameliorates experimental autoimmune myocarditis
Department of Internal Medicine and Cardiology, Kitasato University School of Medicine, Sagamihara, Japan
Circ J 71:397-404. 2007
..Myosin-induced autoimmune myocarditis of rats is a model of human dilated cardiomyopathy. Resveratrol is a natural polyphenol found in grapes and wine that is reported to have cardioprotective and immunomodulatory effects...
- Inhibition of the chemokine receptor CXCR2 prevents kidney graft function deterioration due to ischemia/reperfusion
Transplant Research Center Chiara Cucchi de Alessandri e Gilberto Crespi Mario Negri Institute for Pharmacological Research, Villa Camozzi, Ranica, Bergamo, Italy
Kidney Int 67:1753-61. 2005
..Ischemia/reperfusion (I/R) injury after organ transplantation is a major cause of delayed graft function. Following I/R, locally produced CXC chemokines attract and activate granulocytes, which in turn promote graft damage...
- Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653
Osaka University Graduate School of Medicine, Osaka, Japan
Arthritis Rheum 48:2670-81. 2003
..In this study we investigated the effect of FR167653 on collagen-induced arthritis (CIA)...
- Acute myocarditis in a rat model: late gadolinium enhancement with histopathological correlation
Department of Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Eur Radiol 19:2672-8. 2009
..Thus we think the current animal model can provide the opportunity for further fundamental research into myocarditis...
- Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
J Immunol 172:4618-23. 2004
..Thus, T cells can play a role in angiogenesis by delivering VEGF to inflammatory sites, and VEGF can augment proinflammatory T cell differentiation...
- Cell therapy attenuates cardiac dysfunction post myocardial infarction: effect of timing, routes of injection and a fibrin scaffold
Juliana S Nakamuta
Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Sao Paulo, Brazil
PLoS ONE 4:e6005. 2009
- Selective lack of the C16:0 fatty acid isoform of sulfatide in pancreas of type II diabetic animal models
Institute of Clinical Neuroscience, Experimental Neuroscience Section, The Sahlgrenska Academy at Goteborg University, Sahlgrenska University Hospital Molndal, Sweden
APMIS 111:867-77. 2003
..Thus, it is hypothesized that the selection of sulfatide isomers in pancreas might be a genetic factor contributing to disease development in type II diabetic animal models...
- Acute rejection after rat renal transplantation leads to downregulation of NA+ and water channels in the collecting duct
Universitatsklinikum Munster, Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Munster, Germany
Am J Transplant 5:1276-85. 2005
..These acute downregulations of ENaC and AQP2 may be triggered to reduce energy consumption in the distal nephron to protect the kidney immediately after transplantation...
- Antigen from the anterior chamber of the eye travels in a soluble form to secondary lymphoid organs via lymphatic and vascular routes
School of Anatomy and Human Biology, The University of Western Australia, Crawley Perth
Invest Ophthalmol Vis Sci 47:1039-46. 2006
..To determine the afferent pathways linking the anterior chamber (AC) of the eye to the secondary lymphoid organs...
- Peroxisome proliferator-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis associated with inhibition of self-sensitive T cells
Department of Cardiovascular Medicine, First Hospital of Xi an Jiaotong University, Shaanxi, China
J Cardiovasc Pharmacol 43:868-75. 2004
..In the present study, we investigated the expression of PPAR-gamma and the effect of PPAR-gamma ligands on experimental autoimmune myocarditis (EAM)...
- A CCR1 antagonist prevents the development of experimental autoimmune myocarditis in association with T cell inactivation
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8519, Japan
J Mol Cell Cardiol 40:853-61. 2006
..The CCR1 antagonist reduced the severity of EAM by inhibiting cytokine expression and inducing T cell inactivation. Thus, the CCR1 antagonist may provide a novel therapeutic strategy treatment of myocarditis...
- C16:0 sulfatide inhibits insulin secretion in rat beta-cells by reducing the sensitivity of KATP channels to ATP inhibition
Bartholin Instituttet, Rigshospitalet, 2100 Copenhagen, Denmark
Diabetes 55:2826-34. 2006
..We conclude that a major mechanism by which the predominant sulfatide isoform in beta-cells, C16:0 sulfatide, inhibits glucose-induced insulin secretion is by reducing the K(ATP) channel sensitivity to the ATP block...
- Comparison of anti-arthritic properties of leflunomide with methotrexate and FK506: effect on T cell activation-induced inflammatory cytokine production in vitro and rat adjuvant-induced arthritis
Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, 2 1 6, Kashima, Yodogawa ku, 532 8514, Osaka, Japan
Inflamm Res 53:544-50. 2004
- Sulfatide controls insulin secretion by modulation of ATP-sensitive K(+)-channel activity and Ca(2+)-dependent exocytosis in rat pancreatic beta-cells
Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark
Diabetes 51:2514-21. 2002
..Our data suggest that sulfatide is important for the control of glucose-induced insulin secretion and that both an increase and a decrease in the sulfatide content have an impact on the secretory capacity of the individual beta-cells...
- In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals
Department of Nuclear Medicine, Erasmus MC Rotterdam, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
Eur J Nucl Med Mol Imaging 33:1214-7. 2006
..In vivo quantification of radiopharmaceuticals has great potential as a tool in developing new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole single-photon emission computed tomography (SPECT) in rats...
- Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis
Mary Jo Turk
Purdue University, West Lafayette, Indiana 47907, USA
Arthritis Rheum 46:1947-55. 2002
..To determine whether overexpression of the high-affinity folate receptor (FR) on activated macrophages can be exploited to selectively target imaging agents to sites of inflammation in rats with adjuvant-induced arthritis (AIA)...
- The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis
Department of Neuroimmunology, Max Planck Institute for Neurobiology, 82152 Martinsried, Germany
J Exp Med 199:185-97. 2004
..Low-level reactivation of weakly pathogenic T cells was not due to anergy because these cells could be activated by specific antigen in situ as well as after isolation ex vivo...
- The regulatory C-terminal determinants within mycobacterial heat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications for the pathogenesis of autoimmune arthritis
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Immunol 173:181-8. 2004
..The identification of disease-regulating cryptic determinants in Ags implicated in arthritis provides a novel approach for immunotherapy of rheumatoid arthritis...
- Normalization of glucose post-transplantation of pig pancreatic anlagen into non-immunosuppressed diabetic rats depends on obtaining anlagen prior to embryonic day 35
Sharon A Rogers
Renal Division, Department of Medicine, Washington University School of Medicine, St Louis MO 63110, USA
Transpl Immunol 14:67-75. 2005
- Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist
Chia Huey Lin
Institute for Virology and Immunobiology, University of Wurzburg, Versbacherstrasse 7, D 97078 Wurzburg, Germany
Eur J Immunol 33:626-38. 2003
..These data suggest that CD28-driven activation of Treg cells may be highly effective in the treatment of inflammatory and autoimmune diseases...
- Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis
Laboratoire d'Immunologie, , 13385 Marseille, France
Proc Natl Acad Sci U S A 98:13942-7. 2001
..We conclude that selective targeting of Kv1.3, alone or with IKCa1, may provide an effective new mode of therapy for multiple sclerosis...
- Enhanced gene transfer to arthritic joints using adeno-associated virus type 5: implications for intra-articular gene therapy
Division of Clinical Immunology and Rheumatology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Ann Rheum Dis 64:1677-84. 2005
..Gene therapy of the joint has great potential as a new therapeutic approach for the treatment of rheumatoid arthritis (RA). The vector chosen is of crucial importance for clinical success...
- Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling
Salman R Khetani
Department of Bioengineering at the University of California San Diego, La Jolla, CA 92093 0412, USA
Hepatology 40:545-54. 2004
..g., bioartificial liver devices). In conclusion, the functional genomic approach presented in this study may be utilized to investigate mechanisms of cell-cell interaction in a variety of tissues and disease states...
- A novel azulenyl nitrone antioxidant protects against MPTP and 3-nitropropionic acid neurotoxicities
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
Exp Neurol 191:86-93. 2005
..Our data provide further evidence that STAZN is a neuroprotective free radical spin trap, and suggest that the development of new antioxidants will broaden our therapeutic strategies for neurodegenerative diseases...
- Long-term effects of bone marrow mononuclear cell transplantation on left ventricular function and remodeling in rats
Department of Cardiology, the Third Hospital of Peking University, 49 North Garden Road, Hai Dian District, Beijing, 100083, China
Life Sci 74:2853-64. 2004
- DNA fragments of the human 60-kDa heat shock protein (HSP60) vaccinate against adjuvant arthritis: identification of a regulatory HSP60 peptide
Francisco J Quintana
Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
J Immunol 171:3533-41. 2003
..These results show that regulatory mechanisms can be activated by immunization with relevant self-HSP60 epitopes...
- Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy
Punniyakoti T Veeraveedu
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
Eur J Pharmacol 581:121-31. 2008
- Quantitative analysis of survival of transplanted smooth muscle cells with real-time polymerase chain reaction
Division of Cardiovascular Surgery, Toronto General Research Institute, Toronto General Hospital, Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada
J Thorac Cardiovasc Surg 129:904-11. 2005
..Cell transplantation improves heart function after myocardial infarction. This study investigated the survival of implanted cells in normal and infarcted myocardium...
- Microarray-based gene expression profiles of allograft rejection and immunosuppression in the rat heart transplantation model
Laurie M Erickson
Fujisawa Research Institute of America, Northwestern University Evanston Research Park, Evanston, Illinois 60201, USA
Transplantation 76:582-8. 2003
- DNA microarray analysis of gene expression in iris and ciliary body of rat eyes with endotoxin-induced uveitis
Department of Ophthalmology, School of Medicine, Shinshu University, 3 1 1 Asahi, Matsumoto 390 8621, Japan
Exp Eye Res 80:401-12. 2005
..Our data suggest that the immediate early genes, such as Jun B, play an important role in inducing the inflammatory-related genes in the ICB...
- Protective role of heme oxygenase-1 against endotoxin-induced uveitis in rats
Department of Ophthalmology, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
Exp Eye Res 77:665-73. 2003
..001). Hemin is effective in inducing HO-1 and in reducing the ocular inflammation induced by LPS probably by down-regulating NO and pro-inflammatory cytokine expression...
- Regulatory T cells in experimental allergic encephalomyelitis. III. Comparison of disease resistance in Lewis and Fischer 344 rats
Department of Neurology and the Center for Neuroimmunology of the University of Alabama at Birmingham, 35294, USA
Eur J Immunol 29:1101-6. 1999
..However, the frequency of RTC that functionally inhibit MBP-reactive T cells is greater in F344 rats...
- Renal transplantation modulates expression and function of receptors and transporters of rat proximal tubules
Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, Domagkstrasse 3a, D 48149 Munster, Germany
J Am Soc Nephrol 15:967-77. 2004
..The local renin-angiotensin-system is apparently not altered. Downregulation of NHE-3 may be a protective mechanism occurring in the graft...
- Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis
Rheumatoid Arthritis Disease Biology Department, GlaxoSmithKline, Medicines Research Centre, Stevenage, UK
Arthritis Res Ther 7:R101-17. 2005
..These findings improve our understanding of the molecular events that underlie the pathology in this animal model, which is potentially a valuable comparator to human rheumatoid arthritis (RA)...
- Protective DNA vaccination against experimental autoimmune encephalomyelitis is associated with induction of IFNbeta
Applied Immunology Group, Karolinska Institutet Center for Molecular Medicine L8 04 Karolinska Hospital 171 76, Stockholm, Sweden
J Neuroimmunol 149:66-76. 2004
..We suggest that the underlying mechanism of DNA vaccination is associated with immunomodulation exerted by induced IFNbeta...
- Inhibition of adjuvant-induced arthritis by DNA vaccination with the 70-kd or the 90-kd human heat-shock protein: immune cross-regulation with the 60-kd heat-shock protein
Francisco J Quintana
Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
Arthritis Rheum 50:3712-20. 2004
..We have recently demonstrated that vaccination with human Hsp60 DNA inhibits AIA. The present study was undertaken to analyze the role of the T cell responses to self HSP molecules other than Hsp60 in the control of AIA...
- An intravital and confocal microscopic study of the distribution of intracameral antigen in the aqueous outflow pathways and limbus of the rat eye
School of Anatomy and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Perth 6009, Western Australia
Exp Eye Res 79:455-64. 2004
..In conclusion our data reveal that the majority of intracamerally injected soluble Ag retained in the eye is taken up by resident macrophages not only in the iris but in all tissues lining the AC of the eye...
- Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium
Department of Immunology, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK
Am J Transplant 4:1958-63. 2004
..This genetic strategy could be applied in a clinically relevant species such as the pig...
- Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60
Francisco J Quintana
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
J Immunol 169:3422-8. 2002
..Our results support a regulatory role for HSP60 autoreactivity in AA and demonstrate that this control mechanism can be activated by DNA vaccination with both HSP60 or HSP65...
- Protective role of NHE-3 inhibition in rat renal transplantation undergoing acute rejection
Medizinische Klinik und Poliklinik D, Experimentelle Nephrologie, Universitatsklinikum Munster, Munster, Germany
Pflugers Arch 456:1075-84. 2008
..Observed NHE-I-dependent changes in electrolyte excretion, polyuria, and reduced protein reabsorption in the acute postoperative phase are predictors of favorable graft outcome in humans...
- Comparative anatomy of laboratory animal corneas with a new-generation high-resolution in vivo confocal microscope
Department of Ophthalmology III, Quinze Vingts National Ophthalmology Hospital, Paris, France
Curr Eye Res 31:501-9. 2006
..The aim of the current study was to compare the corneas of three commonly used laboratory animals with a new in vivo confocal microscope...
- Inhibition of interleukin-1 but not tumor necrosis factor suppresses neovascularization in rat models of corneal angiogenesis and adjuvant arthritis
Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
Arthritis Rheum 46:2604-12. 2002
..To assess the capacities of the cytokine inhibitors interleukin-1 receptor antagonist (IL-1Ra; anakinra) and PEGylated soluble tumor necrosis factor receptor I (PEG sTNFRI; pegsunercept) to suppress neovascularization...
- Allogenic immune response promotes the accumulation of host-derived smooth muscle cells in transplant arteriosclerosis
Department of Surgical Sciences, Karolinska Hospital, SE 17176 Stockholm, Sweden
Cardiovasc Res 65:535-45. 2005
..Here, the role of an allogenic immune response in the accumulation of host-derived SMCs in the neointima was explored...