inbred f344 rats

Summary

Top Publications

  1. ncbi Translocation of inhaled ultrafine particles to the brain
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Inhal Toxicol 16:437-45. 2004
  2. ncbi Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 293:607-17. 2000
  3. ncbi Macrophage-derived factors stimulate optic nerve regeneration
    Yuqin Yin
    Laboratories for Neuroscience Research in Neurosurgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 23:2284-93. 2003
  4. ncbi Chemotactic effect of ciliary neurotrophic factor on macrophages in retinal ganglion cell survival and axonal regeneration
    Ling Ping Cen
    Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou University Medical College, Shantou, Peoples Republic of China
    Invest Ophthalmol Vis Sci 48:4257-66. 2007
  5. ncbi Blockade of caspase-1 increases neurogenesis in the aged hippocampus
    Carmelina Gemma
    Center of Excellence for Ageing and Brain Repair, Department of Neurosurgery, University of South Florida, and James A Haley VA Hospital, 13000 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Eur J Neurosci 26:2795-803. 2007
  6. ncbi Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Eur J Neurosci 27:2250-61. 2008
  7. ncbi Identification of adult hepatic progenitor cells capable of repopulating injured rat liver
    Mladen I Yovchev
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 47:636-47. 2008
  8. pmc Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus
    Bharathi Hattiangady
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, United States
    Neurobiol Aging 29:129-47. 2008
  9. pmc Update on the genotoxicity and carcinogenicity of cobalt compounds
    D Lison
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Clos Chapelle aux Champs 3054, 1200 Bruxelles, Belgium
    Occup Environ Med 58:619-25. 2001
  10. ncbi Capture of authentic embryonic stem cells from rat blastocysts
    Mia Buehr
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, Edinburgh EH93JQ, UK
    Cell 135:1287-98. 2008

Detail Information

Publications262 found, 100 shown here

  1. ncbi Translocation of inhaled ultrafine particles to the brain
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Inhal Toxicol 16:437-45. 2004
    ..It could provide a portal of entry into the CNS for solid UFP, circumventing the tight blood-brain barrier. Whether this translocation of inhaled UFP can cause CNS effects needs to be determined in future studies...
  2. ncbi Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 293:607-17. 2000
    ....
  3. ncbi Macrophage-derived factors stimulate optic nerve regeneration
    Yuqin Yin
    Laboratories for Neuroscience Research in Neurosurgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 23:2284-93. 2003
    ..Thus, macrophages produce proteins with both positive and negative effects on RGCs, and the effects of macrophages can be optimized by the timing of their activation...
  4. ncbi Chemotactic effect of ciliary neurotrophic factor on macrophages in retinal ganglion cell survival and axonal regeneration
    Ling Ping Cen
    Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou University Medical College, Shantou, Peoples Republic of China
    Invest Ophthalmol Vis Sci 48:4257-66. 2007
    ..To examine whether ciliary neurotrophic factor (CNTF) has a chemotactic effect on macrophages and whether macrophages are involved in CNTF-induced retinal ganglion cell (RGC) survival and axonal regeneration after optic nerve (ON) injury...
  5. ncbi Blockade of caspase-1 increases neurogenesis in the aged hippocampus
    Carmelina Gemma
    Center of Excellence for Ageing and Brain Repair, Department of Neurosurgery, University of South Florida, and James A Haley VA Hospital, 13000 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Eur J Neurosci 26:2795-803. 2007
    ..These findings demonstrate that the intracerebroventricular administration of Ac-YVAD-CMK reversed the decrease in hippocampal neurogenesis associated with ageing...
  6. ncbi Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor
    Shusaku Uchida
    Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Eur J Neurosci 27:2250-61. 2008
    ....
  7. ncbi Identification of adult hepatic progenitor cells capable of repopulating injured rat liver
    Mladen I Yovchev
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 47:636-47. 2008
    ..It is shown that Thy-1(+) cells are mesenchymal cells with characteristics of myofibroblasts/activated stellate cells. Transplantation experiments reveal that EpCAM(+) cells are true progenitors capable of repopulating injured rat liver...
  8. pmc Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus
    Bharathi Hattiangady
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, United States
    Neurobiol Aging 29:129-47. 2008
    ..Thus, decreased dentate neurogenesis during aging is not attributable to altered number or phenotype of NSCs. Instead, it appears to be an outcome of increased quiescence of NSCs due to changes in NSC milieu...
  9. pmc Update on the genotoxicity and carcinogenicity of cobalt compounds
    D Lison
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Clos Chapelle aux Champs 3054, 1200 Bruxelles, Belgium
    Occup Environ Med 58:619-25. 2001
    ..To integrate recent understandings of the mechanisms of genotoxicity and carcinogenicity of the different cobalt compounds...
  10. ncbi Capture of authentic embryonic stem cells from rat blastocysts
    Mia Buehr
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, Edinburgh EH93JQ, UK
    Cell 135:1287-98. 2008
    ..Rat ES cells will also provide a refined test-bed for functional evaluation of pluripotent stem cell-derived tissue repair and regeneration...
  11. ncbi Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    FASEB J 17:1183-5. 2003
    ..Thus, a proinflammatory shift in the profile of vascular cytokine expression may contribute to the aging-induced phenotypic changes in coronary arteries, promoting the development of ischemic heart disease in the elderly...
  12. ncbi Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
    Haim Y Cohen
    Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Science 305:390-2. 2004
    ..Thus, CR could extend life-span by inducing SIRT1 expression and promoting the long-term survival of irreplaceable cells...
  13. ncbi Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells
    Kevin Park
    School of Anatomy and Human Biology and Western Australian Institute for Medical Research, The University of Western Australia, Crawley, Perth WA 6009, Australia
    J Neurosci 24:10806-15. 2004
    ....
  14. ncbi Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors
    Weigang Wang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 64:8585-94. 2004
    ..ZBP1 reexpression also inhibited metastasis from tumors. These experiments support the involvement in metastasis of the pathways identified in invasive cells, which are regulated by ZBP1...
  15. pmc Iron accumulation with age, oxidative stress and functional decline
    Jinze Xu
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 3:e2865. 2008
    ..These findings strongly suggest that the age-related iron accumulation in muscle contributes to increased oxidative damage and sarcopenia, and that CR effectively attenuates these negative effects...
  16. ncbi Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    J Neurosci 23:3807-19. 2003
    ....
  17. ncbi Novel hepatic progenitor cell surface markers in the adult rat liver
    Mladen I Yovchev
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 45:139-49. 2007
    ..Moreover, study of progenitor cells purified with Ep-CAM antibodies from D-galactosamine injured rat liver, a noncarcinogenic model of progenitor cell activation, verified that progenitor cells expressed these markers...
  18. pmc Purinergic signaling induces thrombospondin-1 expression in astrocytes
    Minh D Tran
    Research Service, Miami Veterans Affairs Medical Center, Miami, FL 33125, USA
    Proc Natl Acad Sci U S A 103:9321-6. 2006
    ....
  19. ncbi PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury
    Jian Min Luo
    Joint Shantou International Eye Center of Shantou University, Shantou, China
    Eur J Neurosci 26:828-42. 2007
    ..In contrast, the MEK/ERK pathway inhibition protected RGCs via macrophage-independent mechanism(s)...
  20. pmc Role of N-terminal amino acids in the potency of anthrax lethal factor
    Pradeep K Gupta
    Laboratory of Bacterial Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 3:e3130. 2008
    ....
  21. ncbi Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Anesthesiology 100:309-14. 2004
    ..This experiment was designed to test the hypothesis that learning of new information is particularly susceptible to prolonged disruption after general anesthesia...
  22. ncbi Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: implications for the mitochondrial theory of aging
    Sharon Judge
    University of Florida, Biochemistry of Aging Laboratory, Gainesville, FL 32611, USA
    FASEB J 19:419-21. 2005
    ..Our results emphasize the importance of studying both mitochondrial populations when attempting to elucidate the contribution of mitochondrial dysfunction to myocardial aging...
  23. ncbi Dynamics of docosahexaenoic acid metabolism in the central nervous system: lack of effect of chronic lithium treatment
    M C Chang
    Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurochem Res 24:399-406. 1999
    ....
  24. ncbi Cell-based assay for high-throughput quantitative screening of CFTR chloride transport agonists
    L V Galietta
    Department of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143-0521, USA
    Am J Physiol Cell Physiol 281:C1734-42. 2001
    ..The fluorescence assay and cell lines should facilitate the screening of novel CFTR activators and the characterization of alternative Cl(-) channels and transporters...
  25. pmc Does oxidative damage to DNA increase with age?
    M L Hamilton
    Department of Physiology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Proc Natl Acad Sci U S A 98:10469-74. 2001
    ..Our study also showed that dietary restriction prevented the age-related increase in oxo8dG levels in mtDNA isolated from the livers of both rats and mice...
  26. pmc Mitochondrial iron accumulation with age and functional consequences
    Arnold Y Seo
    Department of Aging and Geriatrics, Division of Biology of Aging, Genomics and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, FL 32611, USA
    Aging Cell 7:706-16. 2008
    ..Overall, our data suggest that age-dependent accumulation of mitochondrial iron may increase mitochondrial dysfunction and oxidative damage,thereby enhancing the susceptibility to apoptosis...
  27. pmc Translocation of inhaled ultrafine manganese oxide particles to the central nervous system
    Alison Elder
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Environ Health Perspect 114:1172-8. 2006
    ..Studies in monkeys with intranasally instilled gold ultrafine particles (UFPs; <100 nm) and in rats with inhaled carbon UFPs suggested that solid UFPs deposited in the nose travel along the olfactory nerve to the olfactory bulb...
  28. ncbi Olfactory ensheathing cell grafts have minimal influence on regeneration at the dorsal root entry zone following rhizotomy
    John S Riddell
    Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Glia 47:150-67. 2004
    ..We therefore conclude that OEC grafts are of little or no advantage in promoting the in-growth of regenerating afferent fibers at the dorsal root entry zone following rhizotomy...
  29. ncbi Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase
    Li Qian
    The Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, NC 27599 7455, USA
    J Pharmacol Exp Ther 319:44-52. 2006
    ..Together, our results suggest that IL-10 inhibits LPS-induced DA neurotoxicity through the inhibition of PHOX activity in a JAK1-dependent mechanism...
  30. ncbi Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats
    Xizhong Cui
    Critical Care Medicine Department, National Institutes of Health, Bldg 10, Rm 7D43, Bethesda, MD 20892, USA
    Am J Physiol Regul Integr Comp Physiol 286:R699-709. 2004
    ..Although therapies to modulate these host mediators may be applicable fo shock caused by LPS or other bacterial toxins, they may not with LeTx...
  31. ncbi Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus
    Barbara Shukitt-Hale
    USDA ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    Nutr Neurosci 11:172-82. 2008
    ..These results indicate that blueberry polyphenols attenuate learning impairments following neurotoxic insult and exert anti-inflammatory actions, perhaps via alteration of gene expression...
  32. ncbi A soluble receptor decoy protects rats against anthrax lethal toxin challenge
    Heather M Scobie
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, USA
    J Infect Dis 192:1047-51. 2005
    ..Stoichiometric concentrations of sCMG2 protect rats against lethal toxin challenge, making sCMG2 one of the most effective anthrax antitoxins described to date...
  33. ncbi Astroglia induce neurogenesis from adult neural stem cells
    Hongjun Song
    Molecular Neurobiology Laboratory, Howard Hughes Medical Institute at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 417:39-44. 2002
    ....
  34. ncbi Supportive interaction between cell survival signaling and angiocompetent factors enhances donor cell survival and promotes angiomyogenesis for cardiac repair
    Shujia Jiang
    Department of Pathology and Laboratory Medicine, 231 Albert Sabin Way, University of Cincinnati, OH 45267 0529, USA
    Circ Res 99:776-84. 2006
    ..We conclude that supportive interaction between Ang-1 and Akt during MSC transplantation gave better prognosis via enhanced cell survival, improved angiomyogenesis, and restored global cardiac function...
  35. ncbi Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats
    Angelo Pietro Femia
    Department of Pharmacology, University of Florence, 6 Viale Pieraccini, 50139 Florence, Italy
    Carcinogenesis 23:1953-60. 2002
    ..Cycloxygenase-2 expression was increased in the tumours of control rats but not in those from PRE, PRO or PREPRO rats. In conclusion, prebiotic administration in the diet decreases AOM-induced carcinogenesis in rats...
  36. ncbi Mitigation of radiation-induced optic neuropathy in rats by ACE inhibitor ramipril: importance of ramipril dose and treatment time
    Samuel Ryu
    Department of Radiation Oncology and Neurosurgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, Michigan 48202, USA
    J Neurooncol 82:119-24. 2007
    ..This study was to determine the optimum dose and administration time of ramipril for mitigating radiation-induced optic neuropathy...
  37. ncbi Beta-glucuronidase in human intestinal microbiota is necessary for the colonic genotoxicity of the food-borne carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline in rats
    Christèle Humblot
    UR910 Ecology and Physiology of the Digestive Tract, Institut National de la Recherche Agronomique, F 78352 Jouy en Josas Cedex, France
    Carcinogenesis 28:2419-25. 2007
    ..This is the first in vivo demonstration that bacterial beta-glucuronidase plays a pivotal role in the genotoxicity of a common food-borne carcinogen...
  38. ncbi Chronic ginseng consumption attenuates age-associated oxidative stress in rats
    Ying Fu
    Department of Kinesiology and Nutritional Science, University of Wisconsin Madison, Madison, WI 53706, USA
    J Nutr 133:3603-9. 2003
    ..These protective effects are explained in part by elevated antioxidant enzyme activities in the various tissues...
  39. pmc Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure
    Pal Pacher
    National Institute on Alcohol Abuse and Alcoholism, 12420 Parklawn Dr, MSC 8115, Bethesda, MD 20892 8115, USA
    Am J Physiol Heart Circ Physiol 287:H2132-7. 2004
    ..P-V analysis is a sensitive method to determine cardiac function in rats...
  40. ncbi Direct antioxidant properties of creatine
    John M Lawler
    276 B Read Building, Redox Biology and Cell Signaling Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Biochem Biophys Res Commun 290:47-52. 2002
    ..375 mM). To our knowledge, this is the first evidence that creatine has the potential to act as a direct antioxidant against aqueous radical and reactive species ions...
  41. ncbi Bone marrow as a potential source of hepatic oval cells
    B E Petersen
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Science 284:1168-70. 1999
    ..From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability...
  42. ncbi Mucin-depleted foci are modulated by dietary treatments and show deregulation of proliferative activity in carcinogen-treated rodents
    Angelo Pietro Femia
    Department of Pharmacology, University of Florence, Florence, Italy
    Int J Cancer 120:2301-5. 2007
    ..MDF were also identified in azoxymethane-initiated SWR/J mice. These results further confirm that MDF are preneoplastic lesions and could be useful biomarkers of colon carcinogenesis...
  43. pmc H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway
    Heather Francis
    Department of Research and Education, College of Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center, Temple, TX 76504, USA
    Lab Invest 87:473-87. 2007
    ..Downregulation of cAMP-dependent PKA/ERK1/2/Elk-1 phosphorylation (by activation of H3R) is important in the inhibition of cholangiocyte growth in liver diseases...
  44. ncbi The non-MHC quantitative trait locus Cia5 contains three major arthritis genes that differentially regulate disease severity, pannus formation, and joint damage in collagen- and pristane-induced arthritis
    Max Brenner
    Laboratory of Experimental Rheumatology, Robert S Boas Center for Genomics and Human Genetics and Graduate School of Molecular Medicine, North Shore Long Island Jewish LIJ Research Institute, Manhasset, NY 11030, USA
    J Immunol 174:7894-903. 2005
    ..These loci are syntenic to regions on human chromosomes 17q and 5q implicated in the susceptibility to rheumatoid arthritis, suggesting that the identification of these genes will be relevant to human disease...
  45. ncbi Mitochondrial function and apoptotic susceptibility in aging skeletal muscle
    Beatrice Chabi
    Department of Biology, York University, Toronto, Ontario, Canada
    Aging Cell 7:2-12. 2008
    ..These data suggest that the age-related sarcopenia and muscle fatigability are associated with enhanced ROS production, increased mitochondrial apoptotic susceptibility and reduced transcriptional drive for mitochondrial biogenesis...
  46. ncbi Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism
    Eugenio Gaudio
    Division of Anatomy, University La Sapienza, Rome, Italy
    Gastroenterology 130:1270-82. 2006
    ..The role of VEGF in cholangiocyte pathophysiology is unknown. We evaluated the role of VEGF in the regulation of cholangiocyte proliferation in rats that underwent bile duct ligation...
  47. ncbi Possible participation of oxidative stress in causation of cell proliferation and in vivo mutagenicity in kidneys of gpt delta rats treated with potassium bromate
    Takashi Umemura
    Division of Pathology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 257:46-52. 2009
    ..The overall data indicated that while oxidative stress well correlates with induction of cell proliferation in females, its role in males and in generation of in vivo mutagenicity by KBrO(3) in both sexes is limited...
  48. pmc Persistent Borna Disease Virus (BDV) infection activates microglia prior to a detectable loss of granule cells in the hippocampus
    Mikhail V Ovanesov
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Neuroinflammation 5:16. 2008
    ..The data demonstrate for the first time that a non-lytic persistent virus infection of neurons activates microglia long before any measurable neuronal loss...
  49. ncbi Role of angiotensin II and endothelin-1 receptors in aging-related functional changes in rat cardiovascular system
    Akira Ishihata
    Department of Physiology I, Yamagata University School of Medicine, Japan
    Ann N Y Acad Sci 1067:173-81. 2006
    ....
  50. ncbi Differential regulation of metzincins in experimental chronic renal allograft rejection: potential markers and novel therapeutic targets
    C C Berthier
    Division of Nephrology Hypertension, Inselspital, University of Bern, Bern, Switzerland
    Kidney Int 69:358-68. 2006
    ..Thus, an altered pattern of metzincins may represent novel diagnostic markers and possibly may provide novel targets for future therapeutic interventions...
  51. ncbi Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress
    Sufen Yang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, MD F1 01, P O Box 12233, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 319:595-603. 2006
    ....
  52. ncbi Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells
    Yuqin Yin
    Department of Neurosurgery and Neurobiology Program, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 9:843-52. 2006
    ..Oncomodulin also stimulates outgrowth from peripheral sensory neurons. Thus, oncomodulin is a new growth factor for neurons of the mature central and peripheral nervous systems...
  53. ncbi Newly born cells in the ageing dentate gyrus display normal migration, survival and neuronal fate choice but endure retarded early maturation
    Muddanna S Rao
    Division of Neurosurgery, DUMC Box 3807, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Neurosci 21:464-76. 2005
    ....
  54. ncbi Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program
    A Turturro
    Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 9502, USA
    J Gerontol A Biol Sci Med Sci 54:B492-501. 1999
    ....
  55. pmc Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens
    Clifford R Elcombe
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, United Kingdom
    Environ Health Perspect 110:363-75. 2002
    ..The judicious choice of markers and evaluation times can aid the detection of potential nongenotoxic rodent carcinogens...
  56. ncbi High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening
    Tonghui Ma
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 277:37235-41. 2002
    ..The new activators identified here may be useful in defining molecular mechanisms of CFTR activation and as lead compounds in CF drug development...
  57. ncbi Photoresponsive Fischer 344 Rats are reproductively inhibited by melatonin and differ in 2-[125I] lodomelatonin binding from nonphotoresponsive Sprague-Dawley rats
    P D Heideman
    Department of Biology, The College of William and Mary, PO Box 8795, Williamsburg, VA 23187, USA
    J Neuroendocrinol 13:223-32. 2001
    ..In addition, they provide support for the hypothesis that F344 rats may be photoresponsive due to differences from other strains in the location, density, or affinity of melatonin receptors...
  58. ncbi Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord
    P J Horner
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California 92037, USA
    J Neurosci 20:2218-28. 2000
    ....
  59. ncbi Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis
    M Takahashi
    Cancer Prevention Division, National Cancer Center Research Institute, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 21:1319-27. 2000
    ..These results show that beta-catenin alterations may be related to induction of iNOS expression, these being early events in AOM-induced colon tumorigenesis which may play important roles in causing dysplastic changes...
  60. ncbi Magnetic resonance imaging of temperature-sensitive liposome release: drug dose painting and antitumor effects
    Ana M Ponce
    Department of Biomedical Engineering, Duke University, Durham, NC, USA
    J Natl Cancer Inst 99:53-63. 2007
    ....
  61. pmc Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment
    L A Dieleman
    Center for Gastrointestinal Biology and Disease and Division of Digestive Diseases, University of North Carolina at Chapel Hill, North Carolina 27599 7038, USA
    Gut 52:370-6. 2003
    ....
  62. ncbi A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats
    E F Remmers
    Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA
    Nat Genet 14:82-5. 1996
    ..These genes may also represent novel targets for therapy...
  63. pmc Correlation of major histocompatibility complex class I downregulation with resistance of human T-cell leukemia virus type 1-infected T cells to cytotoxic T-lymphocyte killing in a rat model
    Takashi Ohashi
    Department of Immunotherapeutics, Tokyo Medical and Dental University, Medical and Dental Research Division, Tokyo 113 8519, Japan
    J Virol 76:7010-9. 2002
    ..This may be one of the mechanisms for persistence of HTLV-1-infected cells that evade CTL lysis and potentially develop ATL...
  64. ncbi Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines
    Carmelina Gemma
    James A Haley Veterans Affairs Medical Center, Tampa, Florida 33612, USA
    J Neurosci 22:6114-20. 2002
    ..In summary, the improved beta-adrenergic receptor function in aged rats induced by diets rich in antioxidants is related to the ORAC dose, and these diets reduce proinflammatory cytokine levels...
  65. ncbi Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?
    Ilan Gabriely
    Diabetes Research and Training Center and Division of Endocrinology, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Diabetes 51:2951-8. 2002
    ..This study documents a cause-and-effect relationship between VF and major components of the metabolic syndrome...
  66. ncbi Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Neurochem 83:973-83. 2002
    ..This study demonstrates that one of the mechanisms by which microglia can enhance the neurotoxicity of Abeta is via the production of reactive oxygen species...
  67. ncbi Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile
    N V Matusheski
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois 61801, USA
    J Agric Food Chem 49:5743-9. 2001
    ..Therefore, glucoraphanin hydrolysis directed toward the production of SF rather than SF nitrile could increase the potential chemoprotective effects of broccoli...
  68. ncbi Nanoparticle surface charges alter blood-brain barrier integrity and permeability
    Paul R Lockman
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106 1712, USA
    J Drug Target 12:635-41. 2004
    ..NPs were characterized by particle size and zeta potential. BBB integrity and NP brain permeability were evaluated by in situ rat brain perfusion...
  69. ncbi Ontogeny of spatial navigation in rats: a role for response requirements?
    H M Carman
    Research and Graduate Studies, University of Kentucky, Lexington 40536 0082, USA
    Behav Neurosci 115:870-9. 2001
    ....
  70. ncbi Nerve growth factor modulates the proliferative capacity of the intrahepatic biliary epithelium in experimental cholestasis
    Alessandro Gigliozzi
    Division of Gastroenterology, Department of Clinical Medicine, University of Rome La Sapienza, Italy
    Gastroenterology 127:1198-209. 2004
    ..We evaluated the expression of neurotrophins in rat cholangiocytes and the role and mechanisms by which nerve growth factor (NGF) modulates cholangiocyte proliferation...
  71. ncbi Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker
    Alessandro Taddei
    Laboratorio di Genetica Molecolare, Istituto Giannina Gaslini, 16148 Genoa, Italy
    FEBS Lett 558:52-6. 2004
    ..2 microM for DeltaF508 CFTR. Our studies provide evidence for CFTR inhibition by CFTR(inh)-172 by a mechanism involving altered CFTR gating...
  72. ncbi Inhibition by naloxone stereoisomers of beta-amyloid peptide (1-42)-induced superoxide production in microglia and degeneration of cortical and mesencephalic neurons
    Yuxin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 302:1212-9. 2002
    ..Combined with our previous observations with inflammagen-induced neurodegeneration, naloxone analogs, especially (+)-naloxone, may have potential therapeutic efficacy for the treatment of Alzheimer's and Parkinson's disease...
  73. ncbi Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha
    Gianfranco Alpini
    Department of Internal Medicine, Scott and White Hospital and The Texas A and M University System Health Science Center, College of Medicine and Central Texas Veterans Health Care System, Temple, TX 76504, USA
    Hepatology 35:1041-52. 2002
    ..Reduced cholangiocyte ABAT may decrease endogenous BA stimulation of cholangiocyte growth and secretion...
  74. ncbi The role of inflammation, oxidative stress, and proliferation in silica-induced lung disease: a species comparison
    J M Carter
    Procter and Gamble Company, Cincinnati, OH 45251, USA
    J Environ Pathol Toxicol Oncol 20:33-43. 2001
    ..A basic understanding of the different responses of various species to these inhaled toxins will contribute to our understanding of the mechanisms involved in human disease...
  75. ncbi LPS-induced neutrophilic inflammation and Bcl-2 expression in metaplastic mucous cells
    Jennifer E Foster
    Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA
    Am J Physiol Lung Cell Mol Physiol 285:L405-14. 2003
    ..These data demonstrate that Bcl-2 expression is independent of the number of neutrophils in the BAL and that bezafibrate may directly reduce Bcl-2 expression in epithelial cells...
  76. ncbi Shift toward an alternatively activated macrophage response in lungs of NO2-exposed rats
    Holger Garn
    Institute of Immunology, Department of Pathology, Laboratory of Lung Cell Biology, Philipps University Marburg, Marburg, Germany
    Am J Respir Cell Mol Biol 28:386-96. 2003
    ..In conclusion, a priming toward development of the alternatively activated macrophage phenotype occurred in the lungs of rats following nitrogen dioxide inhalation...
  77. ncbi Inflammatory blockade restores adult hippocampal neurogenesis
    Michelle L Monje
    Stanford University, Department of Neurosurgery, MSLS P309, Mail Code 5487, 1201 Welch Road, Stanford, CA 94305 5487, USA
    Science 302:1760-5. 2003
    ....
  78. ncbi Bone marrow-derived hepatic oval cells differentiate into hepatocytes in 2-acetylaminofluorene/partial hepatectomy-induced liver regeneration
    Seh Hoon Oh
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Gastroenterology 132:1077-87. 2007
    ..The present study analyzed whether the bone marrow cells are a source of hepatic oval cells involved in rat liver regeneration induced by 2-acetylaminofluorene (2-AAF) and 70% partial hepatectomy (PHx)...
  79. pmc Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells
    Hemant Sarin
    National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Transl Med 6:80. 2008
    ..Using functionalized polyamidoamine dendrimer generations 1 through 8, we investigated how nanoparticle size influences particle accumulation within malignant glioma cells...
  80. ncbi Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release
    John C Gant
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Medical Center, Lexington, Kentucky 40536 0298, USA
    J Neurosci 26:3482-90. 2006
    ..Thus, this study provides the first evidence that altered CICR plays a role in driving the early and simultaneous emergence in hippocampus of multiple Ca2+-related biomarkers of aging...
  81. ncbi Targeted delivery of methotrexate to epidermal growth factor receptor-positive brain tumors by means of cetuximab (IMC-C225) dendrimer bioconjugates
    Gong Wu
    Department of Pathology, The Ohio State University, 165 Hamilton Hall, 1645 Neil Avenue, Columbus, 43210, USA
    Mol Cancer Ther 5:52-9. 2006
    ..Our results, which are both positive and negative, show that specific molecular targeting is but one of several requirements that must be fulfilled if an antibody-drug bioconjugate will be therapeutically useful...
  82. ncbi Progesterone inhibits mature rat dendritic cells in a receptor-mediated fashion
    Cherie L Butts
    Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health National Institutes of Health, 5625 Fishers Lane, Bethesda, MD 20892, USA
    Int Immunol 19:287-96. 2007
    ..This mechanism could contribute to or account for some of the differential expression of autoimmune/inflammatory disease in females...
  83. pmc Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells
    Qilin Cao
    Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, Kentucky 40202, USA
    J Neurosci 25:6947-57. 2005
    ..Therefore, combined treatment with neurotrophins and GRP grafts can facilitate functional recovery after traumatic SCI and may prove to be a useful therapeutic strategy to repair the injured spinal cord...
  84. ncbi Chemoprevention of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced colonic and hepatic preneoplastic lesions in the F344 rat by cruciferous vegetables administered simultaneously with the carcinogen
    Fekadu Kassie
    Institute of Cancer Research, Borschkegasse 8a, 1090 Vienna, Austria
    Carcinogenesis 24:255-61. 2003
    ..Our findings support the assumption that Brassica vegetables protect against the carcinogenic effects of heterocyclic amines...
  85. ncbi K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine
    Angelo Pietro Femia
    Department of Pharmacology, University of Florence, Florence, Italy
    Int J Cancer 122:117-23. 2008
    ....
  86. ncbi Reproductive photoresponsiveness in unmanipulated male Fischer 344 laboratory rats
    P D Heideman
    Biology Department, College of William and Mary, Williamsburg, Virginia 23187 8795, USA
    Biol Reprod 57:134-8. 1997
    ....
  87. ncbi Improvement of memory for context by inhibition of caspase-1 in aged rats
    Carmelina Gemma
    James A Haley VA Hospital, 13000 Bruce B Downs Blvd, Tampa, FL, 33612, USA
    Eur J Neurosci 22:1751-6. 2005
    ..Chronic infusion of a specific caspase-1 inhibitor in aged rats ameliorated age-related increases in hippocampal IL-1beta and improved memory for context...
  88. ncbi Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system
    Ingrid Stromberg
    Department of Integrative Medical Biology, Umea University, S 901 87 Umea, Sweden
    Exp Neurol 196:298-307. 2005
    ..In conclusion, enhanced striatal dopamine recovery appeared in animals treated with diet enriched in antioxidants and anti-inflammatory phytochemicals and coincided with an early, transient increase in OX-6-positive microglia...
  89. ncbi Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis
    Barbara Peters
    Department of Cardiovascular Medicine, University of Greifswald, Greifswald, Germany
    J Hypertens 26:102-9. 2008
    ..In cyp1a1ren-2 transgenic rats, prorenin levels and arterial pressure can be increased by oral administration of indole-3-carbinol (I3C). The transgenic strain has been used as a model of malignant hypertension...
  90. ncbi Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord
    Laura Taylor
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 26:9713-21. 2006
    ..These findings indicate that a localized and continuous gradient of NT-3 can achieve axonal bridging beyond the glial scar, but growth for longer distances is not sustainable simply with a trophic stimulus...
  91. ncbi Background gene expression in rat kidney: influence of strain, gender, and diet
    Shawn D Seidel
    Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA
    Toxicol Sci 94:226-33. 2006
    ..These results demonstrate that gender and strain have significant influence on gene expression which could be a confounder when comparing results, especially when it involves predictive fingerprint/patterns...
  92. ncbi Effect of dietary fat on metabolism and DNA adduct formation after acute oral exposure of F-344 rats to fluoranthene
    Stormy A Walker
    Department of Pharmacology, Meharry Medical College, Nashville, TN 37208, USA
    J Nutr Biochem 18:236-49. 2007
    ....
  93. ncbi Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats
    Deborah J Culley
    Department of Anesthesiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Anesth Analg 99:1393-7; table of contents. 2004
    ..05). There were no differences in total number of errors (P < or = 0.06). Thus, spatial memory is impaired for 2 wk after general anesthesia in aged rats independent of whether nitrous oxide is used...
  94. pmc Connective tissue growth factor with a novel fibronectin binding site promotes cell adhesion and migration during rat oval cell activation
    Liya Pi
    Department of Pathology Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA
    Hepatology 47:996-1004. 2008
    ..Recombinant CTGF promoted an integrin alpha(5)beta(1)-dependent migration but not proliferation on Thy1(+) oval cells...
  95. pmc Advancing age alters the expression of the ryanodine receptor 3 isoform in adult rat superior cervical ganglia
    Conwin K Vanterpool
    Dept of Physiology and Pharmacology, Loma Linda Univ, School of Medicine, Loma Linda, CA 92350, USA
    J Appl Physiol (1985) 101:392-400. 2006
    ..In addition, these data may part provide some insight into the possible changes in the function of RyRs that may occur with the normal aging process...
  96. ncbi Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus
    Bharathi Hattiangady
    Department of Surgery Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 195:353-71. 2005
    ..Dramatically diminished CREB phosphorylation (and persistently reduced levels of BDNF and NPY) at old age may underlie the learning and memory impairments observed during senescence...
  97. ncbi Brussels sprouts, inulin and fermented milk alter the faecal microbiota of human microbiota-associated rats as shown by PCR-temporal temperature gradient gel electrophoresis using universal, Lactobacillus and Bifidobacterium 16S rRNA gene primers
    Christèle Humblot
    National Institute for Agronomic Research INRA, Unit on Ecology and Physiology of the Digestive Tract UEPSD, 78352 Jouy en Josas Cedex, France
    Br J Nutr 93:677-84. 2005
    ..This experiment shows for the first time that cruciferous vegetables are able to alter the diversity and the metabolic activities of the digestive microbiota in HMA rats...
  98. ncbi Hepatocyte growth factor as well as vascular endothelial growth factor gene induction effectively promotes liver regeneration after hepatectomy in Solt-Farber rats
    Hideaki Oe
    Department of Surgery and Surgical Basic Science, Kyoto University School of Medicine, Kyoto Japan
    Hepatogastroenterology 52:1393-7. 2005
    ..The aim of this study was to examine the effect of hepatocyte growth factor (HGF), or vascular endothelial growth factor (VEGF) on proliferation of oval cells in the Solt-Farber rat model...
  99. ncbi Spatial memory performance 2 weeks after general anesthesia in adult rats
    Catherine Crosby
    Department of Physiology, Harvard University, Cambridge, MA, USA
    Anesth Analg 101:1389-92. 2005
    ..005). Hence, in adult rats, previous general anesthesia is not associated with impaired learning 2 wk later. In fact, previous 1.2% isoflurane-70% nitrous oxide improves maze performance 2 wk later...
  100. ncbi In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate
    Takashi Umemura
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
    Cancer Sci 97:829-35. 2006
    ..The two-step experiment shows that cells exposed to the alteration of the intranuclear status by oxidative stress including 8-OHdG formation might be able to form tumors with appropriate promotion...
  101. ncbi Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a 28-day repeat-dose toxicity study
    Koji Nakayama
    Research Division for Advanced Technology, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd, 14 Sunayama, Kamisu, Ibaraki 314 0255, Japan
    Toxicol Appl Pharmacol 217:299-307. 2006
    ....

Research Grants66

  1. BIOARTIFICIAL MUSCLES FOR GENE THERAPY
    Herman Vandenburgh; Fiscal Year: 2002
    ..New therapeutic treatments with recombinant proteins for chronic musculoskeletal wasting disorders will lead to enhanced quality of life and reduced costs in this 150 billion dollar annual U.S. healthcare market. ..
  2. Mechanisms of Functional Recovery After Partial Nerve Injury
    Michael M Wang; Fiscal Year: 2012
    ..The drugs we will test are already available for the treatment of other disorders. Thus, these experiments may soon lead to development of new treatments to enhance neurological recovery after traumatic nerve injury. ..
  3. Genetics of struvite formation
    Leticia Reyes; Fiscal Year: 2010
    ....
  4. mtDNA mutation/heteroplasmy: a sensitive functional biomarker of oxidative stress
    Bruce N Ames; Fiscal Year: 2010
    ..The assay will help scientists better understand how oxidative stress leads to disease and will also provide a way to measure functional benefits of dietary antioxidant supplementation. ..
  5. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok K Shetty; Fiscal Year: 2010
    ..Collectively, the proposed experiments have immense value for the development of apt treatment strategy that prevents both chronic epilepsy and learning and memory impairments after hippocampal injury in adults. ..
  6. Inhibition of Rat Oral Carcinogenesis by Dietary Black Raspberries
    Christopher M Weghorst; Fiscal Year: 2013
    ....
  7. Estrogens, Ovarian Aging and Calcium Channel Modulation
    William H Griffith; Fiscal Year: 2013
    ..abstract_text> ..
  8. Molecular Mechanism of Kidney Aging
    Zhongjie Sun; Fiscal Year: 2013
    ..The results will reveal novel molecular pathways that mediate the pathogenesis of aging-related kidney damage. Completion of this project may offer new insights into therapeutic strategies for aging-related kidney damage. ..
  9. Mass Spectrometry based molecular imaging of native biological nanodomains
    FRANCISCO FERNANDEZ-LIMA; Fiscal Year: 2013
    ..abstract_text> ..
  10. Sympathetic Neural Regulation and Aging: Medullary Mechanisms and Strategies
    Michael J Kenney; Fiscal Year: 2013
    ....
  11. ENALS IN TUMORIGENESIS
    Fung Lung Chung; Fiscal Year: 2010
    ..These studies will provide insight into the significance of cyclic dG modifications as a class of endogenous DNA lesions in apoptosis and shed light on the mechanisms by which omega-3 fatty acids protect against colon carcinogenesis. ..
  12. Early experiences, oxytocin, and dysfunctional play of the Fischer 344 rat
    Stephen M Siviy; Fiscal Year: 2013
    ..As an R15 application, this project will also provide rich opportunities for undergraduates at many levels of instruction to become involved in a vibrant research program. ..
  13. BIOMARKERS OF NNK AND NNN METABOLISM IN HUMANS
    Peter Foiles; Fiscal Year: 1993
    ..This information will allow us to develop quantitative measures of risk which are more accurate than that possible using simple measures of exposure...
  14. Studies to evaluate the tox and carcinogentic potential of test articles
    MILTON D HEJTMANCIK; Fiscal Year: 2011
    ..abstract_text> ..
  15. MURINE CRD: A MODEL OF CHRONIC PULMONARY IMFLAMMATION
    Gail Cassell; Fiscal Year: 1991
    ....
  16. Aged F344 Rat Colony
    RICHARD MATACCHIERO; Fiscal Year: 2011
    ..The purpose of this project is to develop, maintain and distribute a standing colony of aged F344 rats for use by investigators in studies of aging...
  17. Aged F344 Rat Colony
    RICHARD MATACCHIERO; Fiscal Year: 2009
    ..The purpose of this project is to develop, maintain and distribute a standing colony of aged F344 rats for use by investigators in studies of aging...
  18. Aged F344 Rat Colony
    RICHARD MATACCHIERO; Fiscal Year: 2012
    ..The purpose of this project is to develop, maintain and distribute a standing colony of aged F344 rats for use by investigators in studies of aging. ..
  19. Aged F344 Rat Colony
    RICHARD MATACCHIERO; Fiscal Year: 2013
    ..The purpose of this project is to develop, maintain and distribute a standing colony of aged F344 rats for use by investigators in studies of aging. ..
  20. STUDIES TO EVALUATE THE TOXIC AND CARCINOGENIC POTENTIAL
    Jeffrey Dill; Fiscal Year: 2009
    ..Cobalt metal 14 and 90 day as well as 2-year studies have been reported. Keywords Carcinogenicity;Toxicity;Bioassay;F344 rats;B6C3F1 mice;inhalation exposure;1-Bromopropane;Cobalt metal;Diethylamine;Triethylamine. ..
  21. IMMUNOLOGIC BASIS ENIVR MODULATION OF AUTOIM ARTHRITIS
    KAMAL MOUDGIL; Fiscal Year: 2001
    ....
  22. Isothiocyanates in the Chemoprevention of Bladder Cancer
    Yuesheng Zhang; Fiscal Year: 2007
    ..Aim 5 will determine the efficacy of an orally administered ITC in inhibiting N-butyl-N- (4-hydroxybutyl)-nitrosamine-induced bladder tumorigenesis in F344 rats. ..
  23. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  24. Chemoprevention of Tobacco Related Cancer in Animals
    Michael Pereira; Fiscal Year: 2004
    ....
  25. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..Tissue distribution and comparative metabolism studies of curcumin and PEMC will be studied with synthetic [3H] curcumin and [3H]-PEMC in vivo in male F-344 rats. ..
  26. CALCIUM INHIBITION OF COLON CANCER PROGRESSION
    Michael Wargovich; Fiscal Year: 1993
    ....
  27. SENESCENCE ALTERS SYMPATHETIC REGULATION TO HEAT STRESS
    MICHAEL KENNEY; Fiscal Year: 2004
    ..The proposed studies will, for the first time, advance the hypothesis that the working strategies employed by sympathetic neural circuits to respond to heat stress are modified by aging. ..
  28. Aged F344 Rat Colony
    KENNETH EHLEN; Fiscal Year: 2009
    ..Provision for a supply of aged rats is essential to the achievement of NIA research objectives by NIA grantees. ..
  29. Studies to evaluate the tox and carcinogentic potential of test articles
    Milton Hejtmancik; Fiscal Year: 2010
    ..abstract_text> ..
  30. Aged F344 Rat Colony
    KENNETH EHLEN; Fiscal Year: 2012
    ..Provision for a supply of aged rats is essential to the achievement of NIA research objectives by NIA grantees. ..
  31. SLEEP, AGING, AND THE HYPOCRETIN/OREXIN SYSTEM
    THOMAS KILDUFF; Fiscal Year: 2007
    ..To address these questions, we will use a combination of in vivo physiological, neuroanatomical, molecular, and receptor pharmacological methods. ..
  32. Mechanistic Studies on the Disposition of Farnesol with Single and Multiple Dosin
    Thomas Cook; Fiscal Year: 2007
    ..SA2: Determine the intestinal disposition and intestinal tissue kinetics of farnesol in Fisher F344 rats. [unreadable] [unreadable] [unreadable]..
  33. ALCOHOL REWARD AND BRAIN DOPAMINE--PHARMACO-MODULATIONS
    ELIOT GARDNER; Fiscal Year: 1993
    ..Research is required to specifically delineate the potential of agents that alter dopaminergic function..and..to identify the precise mechanisms by which the opioid system alters drinking behavior..")...
  34. TISSUE ENGINEERED MYOFIBERS FOR GENE THERAPY
    Herman Vandenburgh; Fiscal Year: 2001
    ..S. health care market. ..
  35. SALT PREFERENCE--INFLUENCE OF STRAIN AND AGE
    ILENE BERNSTEIN; Fiscal Year: 2000
    ....
  36. GLYCOSAMINOGLYCANS: TREATMENT FOR ALZHEIMER'S DISEASE
    Israel Hanin; Fiscal Year: 2002
    ..the potential commercial outcome of these studies would be the development of new, effective agents for the prevention and/or treatment of Alzheimer's Disease. ..
  37. GENES CONTROLLING VIRUS INDUCED ASTHMA IN RATS
    William Castleman; Fiscal Year: 2002
    ....
  38. Ethanol and synaptic plasticity in the cerebellum
    CHIMING HUANG; Fiscal Year: 2004
    ..To ensure that the observed synaptic reorganization/loss and functional deficit occur without significant cell loss, we will employ unbiased stereology to evaluate the number of granule cells and Purkinje cells. ..
  39. DENDRITIC PARAMETERS--AGE AND ETHANOL EFFECTS
    Roberta Pentney; Fiscal Year: 1999
    ..This information is expected to promote the development of pharmacological interventions that will contribute to the health of elderly individuals in need of pharmacological assistance during recovery from long term alcohol dependency. ..
  40. AUTONOMIC CONTROL OF LACRIMAL GLAND FUNCTION
    BARRY BROMBERG; Fiscal Year: 1992
    ..Cultured cells will be stimulated with autonomic agonists to secrete radio-labeled exocytotic proteins. Rates of secretion will be measured, and the electrophoretic pattern of secreted proteins will be determined by fluorography...
  41. IN VIVO STUDIES OF ETHANOL AGING AND OSTEOPENIA
    HORACE PERRY; Fiscal Year: 1992
    ....
  42. AGING, HIGH SUCROSE DIETS AND PANCREATIC FUNCTION
    ROGER MCDONALD; Fiscal Year: 1993
    ....
  43. Aging, Hypoxia, and Sympathetic Cardiac Projections
    Zixi Cheng; Fiscal Year: 2004
    ..Collectively, the proposed experiments will advance our knowledge of brain-heart interactions and provide unique insights into the remodeling of sympathetic outflow to cardiac tissues during aging and following CIH. ..
  44. DETERMINANTS OF PITUITARY DEVELOPMENT
    Joel Schechter; Fiscal Year: 1992
    ..Methods used in our studies are light- and electron microscopy, immunocytochemistry and cryo-immunocytochemistry, and radioimmunoassay...
  45. CHRONIC TOXICITY STUDY OF SALICYLAZOSULFAPYRIDINE
    J Prejean; Fiscal Year: 1991
    ....
  46. CHRONIC TOXICITY STUDIES OF TRIETHANOLAMINE
    ARTHUR PETERS; Fiscal Year: 1991
    ..Results of these studies will provide information about the toxicity of chemicals in experimental animals, which can be used to predict possible hazard to humans...
  47. TOXICOLOGIC & CARCINOGENIC CHEMICALS IN ANIMALS
    JOE PREJAEAN; Fiscal Year: 2000
    ..2-Methylimidazole involves 2-year studies via dosed feed, with special studies including thyroid hormones and UDP-GT. 4-Methylimidazole involves 2-year studies via dosed feed, with special studies including thyroid hormones and UDP-GT. ..
  48. EFFICACY STUDIES OF CHEMOPREVENTIVE AGENTS IN ANIMAL MOD
    David McCormick; Fiscal Year: 2000
    ..For histopathologic confirmation, tissues and gross lesions shall be fixed in 10% buffered formalin, embedded in paraffin blocks and processed by conventional histologic methods using H&E staining. ..
  49. GENETIC MONITORING OF RODENTS
    Carol Whisnant; Fiscal Year: 2000
    ....
  50. ADULT-DERIVED STEM CELL DIFFERENTIATION IN THE HEART
    Page Anderson; Fiscal Year: 2006
    ..The proposed studies will provide new and important information about the functional properties of stem cell-derived cardiac myocytes and the potential value of stem cell-based approaches to treating heart failure. ..
  51. CHRONIC TOXICITY STUDIES OF PROPANEDIOL
    J Prejean; Fiscal Year: 1991
    ..To monitor progress of chemically-induced lesions, interim sacrifices will be conducted with the stop study animals at 3, 6, 12, and 18 months...
  52. DIVINYLBENZENE & STODARD SOLVENTS (I-A, II-C)
    Billy Chou; Fiscal Year: 1999
    ..Special studies in the subchronic study include hematology, clinical chemistries, SMVCE and micronuclei (mice). The 2-year studies involve the treatment of 50 animals per sex/species at 3 exposure concentrations plus controls. ..
  53. RODENT PRODUCTION CENTERS
    SAMUEL PHELAN; Fiscal Year: 1993
    ..Centralized colonies of disease-free, genetically homogeneous and microbiologically defined rodents will ensure an adequate and continuous supply of defined quality animals for the NTP toxicology research and testing program...
  54. AGING AND CENTRAL IL-1B CONTROL OF GLUCOSE HOMEOSTASIS
    Lacinda DeCicco; Fiscal Year: 1999
    ..c.v.) Infection of IL-1beta. This research will lead to a better understanding of the alternations in glucose metabolism observed during aging and, possibly, to more effective treatments for this problem. ..
  55. CHRONIC TOXICITY STUDIES OF P-NITROBENZOIC ACID
    J Prejean; Fiscal Year: 1991
    ..All grossly visible lesions and all tissues with non-neoplastic or neoplastic associated with chemicalo exposure lesions will receive a complete histopathologic examination...
  56. Role of the Amygdala in Opioid Self-administration in Rats with Chronic Pain.
    Thomas Martin; Fiscal Year: 2009
    ....
  57. Repair of Chronially Injured Hippocampus by Grafts
    Ashok Shetty; Fiscal Year: 2006
    ..These studies also have implications for the treatment of other neurodegenerative conditions such as stroke and head injury. [unreadable] [unreadable]..
  58. Colon and liver anticarcinogenicity by acetaminophen
    Gary Williams; Fiscal Year: 2004
    ..In addition, these experiments will provide support for the epidemiological observations of reduced cancer risk associated with the use of APAP. ..
  59. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2006
    ..abstract_text> ..
  60. AGING AND 6 HYDROXYDOPAMINE NEUROTOXICITY
    Wayne Cass; Fiscal Year: 2005
    ....
  61. Calcitriol and Methamphetamine Neurotoxicity
    Wayne Cass; Fiscal Year: 2008
    ..Furthermore, if calcitriol is effective, it could have therapeutic applications in other disease processes where there is a loss of monoamine neurons, such as in Parkinson's disease. [unreadable] [unreadable] [unreadable]..
  62. Calcitriol-Induced Restoration of Dopamine in a Model of Parkinson's Disease
    Wayne Cass; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  63. LC-MS/MS Methods for Analysis of Hemoglogbin Adducts
    Timothy Fennell; Fiscal Year: 2004
    ..abstract_text> ..
  64. CHEMICAL INDUCED NEPHROTOXICITY--SUCCINIMIDES
    GARY RANKIN; Fiscal Year: 2001
    ..Collectively, the results of these studies should add important, new knowledge about the nephrotoxic and urotoxic species of succinimides, cellular targets of the toxicant species and potential mechanisms of nephrotoxicity. ..