- Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration
Richard T Libby
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Vis Neurosci 22:637-48. 2005
..This information should help with the design of experiments, and we present the data in a manner that will be useful for future studies of retinal ganglion cell degeneration and optic neuropathy...
- Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice
Tatjana C Jakobs
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114
J Cell Biol 171:313-25. 2005
..However, the architecture of the mouse eye seems to preclude a commonly postulated source of mechanical damage within the nerve head...
- Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
Nat Genet 35:84-9. 2003
- Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma
Department of Ophthalmology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 280:31240-8. 2005
..The possibility that altered IL-18 expression in the eye of DBA/2J mice initiates and/or amplifies the pathogenesis of pigmentary glaucoma requires further investigation...
- Genetics of gene expression surveyed in maize, mouse and man
Eric E Schadt
Rosetta Inpharmatics, LLC, 12040 115th Avenue N E, Kirkland, Washington 98034, USA
Nature 422:297-302. 2003
..We identify a gene expression pattern strongly associated with obesity in a murine cross, and observe two distinct obesity subtypes. Furthermore, we find that these obesity subtypes are under the control of different loci...
- High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma
Michael G Anderson
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Proc Natl Acad Sci U S A 102:4566-71. 2005
..Because of the robust protective effect, this treatment offers another tool for studying mechanisms of neuroprotection...
- Metabolic adaptations of three inbred strains of mice (C57BL/6, DBA/2, and 129T2) in response to a high-fat diet
The University of Melbourne, Department of Medicine, AH NH, Heidelberg Repatriation Hospital, Heidelberg Heights, Victoria 3081 Australia
J Nutr 134:3264-9. 2004
..It further highlights that the background strain used to produce genetically modified mice is critical to the resultant phenotype...
- CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis
Mary E Morgan
Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 48:1452-60. 2003
..We wished to evaluate their potential for influencing systemic and chronic joint inflammation by investigating their involvement in collagen-induced arthritis (CIA)...
- Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
Genetics 172:1783-97. 2006
..However, even with a very large panel of RILs, mapping resolution may not be sufficient to identify single genes unambiguously. Our results are generally applicable to the design of RILs in other species...
- Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer
Laboratory of Cellular Biochemistry, Animal Resource Sciences/Veterinary Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Biol Reprod 65:1813-21. 2001
..Thus, a major cause of placentomegaly is expansion of the spongiotrophoblast layer, which consequently disturbs the architecture of the layers in the placenta and partially damages its function...
- Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen
Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
J Immunol 162:1018-23. 1999
..We conclude that adaptive immune responses are not the only arthritogenic mechanism and hypothesize that the nonantigenic properties of type II collagen can also lead to arthritis...
- An integrative genomics approach to the reconstruction of gene networks in segregating populations
Rosetta Inpharmatics, Seattle, WA, USA
Cytogenet Genome Res 105:363-74. 2004
- Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 50:650-9. 2004
..This T cell cytokine is implicated in the initiation phase of arthritis. However, the role of IL-17 during the effector phase of arthritis has still not been identified; this was the objective of the present study...
- An integrative genomics approach to infer causal associations between gene expression and disease
Eric E Schadt
Rosetta Inpharmatics, Seattle, Washington 98109, USA
Nat Genet 37:710-7. 2005
..We also demonstrate the utility of this approach by identifying and experimentally validating the involvement of three new genes in susceptibility to obesity...
- Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis
Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Arthritis Rheum 60:2294-303. 2009
..The involvement of IL-17-producing gamma/delta T cells in SKG mice with autoimmune arthritis and patients with rheumatoid arthritis (RA) was also investigated...
- Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors
Department of Genetics and Pathology, Uppsala University, S 75185 Uppsala, Sweden
J Exp Med 191:1611-6. 2000
..In comparison, DBA/1 mice lacking FcgammaRII developed an augmented IgG anticollagen response and arthritis. These observations suggest a crucial role of FcgammaRI and FcgammaRIII in triggering autoimmune arthritis...
- T2Rs function as bitter taste receptors
Howard Hughes Medical Institute and Department of Biology, University of California, San Diego, La Jolla 92093, USA
Cell 100:703-11. 2000
..Since a single taste receptor cell expresses a large repertoire of T2Rs, these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds...
- Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric
Cassandra L Schlamp
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
BMC Neurosci 7:66. 2006
- The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria
Xiaoxin X Wang
Department of Medicine, University of Colorado Denver, and Veterans Affairs Medical Center, Aurora, Colorado, USA
Am J Physiol Renal Physiol 297:F1587-96. 2009
- Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
J Clin Invest 95:2868-76. 1995
..These data suggest that MIP-1 alpha and MIP-2 play a crucial role in the initiation and maintenance, while IL-10 appears to play a regulatory role during the development of experimental arthritis...
- PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models
Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029 6574, USA
J Virol 84:4442-50. 2010
..In summary, our study demonstrates that PB1-F2 expression by the Cal/09 virus modulates the immune response to infection while having a minimal effect on virus virulence in two mammalian models...
- Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma
Michael G Anderson
The Jackson Laboratory, Bar Harbor, ME, USA
BMC Biol 4:20. 2006
..We initiated a study of congenic strains to further define the genetic requirements and disease mechanisms of the D2 glaucoma...
- Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice
Michael G Anderson
The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
Nat Genet 30:81-5. 2002
..The fact that hypopigmentation profoundly alleviates the D2 disease indicates that therapeutic strategies designed to decrease pigment production may be beneficial in human pigmentary glaucoma...
- The genetic control of neocortex volume and covariation with neocortical gene expression in mice
Shiv M Gaglani
Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
BMC Neurosci 10:44. 2009
..Here we use unbiased stereological techniques to map quantitative trait loci (QTLs) that modulate the volume of neocortex...
- Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice
Edward S Brodkin
Department of Psychiatry, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Room 111, Philadelphia, PA 19104 6140, USA
Brain Res 1002:151-7. 2004
..Thus, this phenotype is affected by spontaneous genetic variation in mice and can be measured in an assay useful for future neurogenetic studies...
- Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains
Sheryl S Moy
North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Behav Brain Res 176:4-20. 2007
..Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses...
- B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells
Yi Ling Hu
Department of Inflammation, Amgen, Inc, Thousand Oaks, CA 91320, USA
J Immunol 182:1421-8. 2009
..These findings further support the role of ICOS in autoimmunity and suggest that the expansion of the T(FH) cell pool is an important mechanism by which ICOS regulates Ab production...
- Synergistic protection against cartilage destruction by low dose prednisolone and interleukin-10 in established murine collagen arthritis
L A Joosten
Department of Rheumatology, University Hospital Nijmegen, The Netherlands
Inflamm Res 48:48-55. 1999
..To investigate potential synergy of low dosages glucocorticosteroids (GC's) and interleukin-10 (IL-10), using established murine collagen-induced arthritis (CIA) as a model...
- Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection
Xencor, Monrovia, CA 91016, USA
J Immunol 179:1872-83. 2007
- Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction
Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Arthritis Rheum 52:1585-94. 2005
..The current study was performed to determine whether systemic delivery of a soluble Tie2 receptor (ExTek) using an adenoviral vector (AdExTek) as a Tie2 inhibitor affects arthritis development and progression in an animal model...
- The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF
I K Campbell
Inflammation Research Centre, The University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia
J Leukoc Biol 68:144-50. 2000
..Our results also show that M-CSF-dependent cells are essential for CIA development, suggesting M-CSF may be a suitable target for therapeutic intervention in RA...
- DNA methylation errors in cloned mice disappear with advancement of aging
Laboratory of Cellular Biochemistry, Animal Resource Sciences Veterinary Medical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
Cloning Stem Cells 9:293-302. 2007
..Interestingly, we could detect only one aberrantly methylated locus in two of the three adult clones in mid-age and none of four senescent clones, indicating that errors in DNA methylation disappear with advancement of animals' aging...
- Altered expression of skeletal muscle myosin isoforms in cancer cachexia
Gary M Diffee
Biodynamics Laboratory, University of Wisconsin, Madison, Wisconsin 53706, USA
Am J Physiol Cell Physiol 283:C1376-82. 2002
..MHC isoform content was not significantly different from control in plantaris and gastrocnemius muscles. These data are the first to show a change in myosin isoform expression accompanying muscle atrophy during cancer cachexia...
- Trypanosoma cruzi: role of host genetic background in the differential tissue distribution of parasite clonal populations
Luciana O Andrade
Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270 901 MG, Brazil
Exp Parasitol 100:269-75. 2002
- Genomic analysis of metabolic pathway gene expression in mice
Department of Human Genetics, Molecular Biology Institute, University of California, Los Angeles, CA 90095 1679, USA
Genome Biol 6:R59. 2005
..Quantitative trait locus analyses were applied to the subcutaneous fat-mass trait and all gene-expression data. These data were then used to identify gene sets that are differentially perturbed in lean and obese mice...
- Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis
Laboratory of Immunobiology, Rega Institute, Leuven, Belgium
Ann Rheum Dis 68:744-50. 2009
..A similar situation has been described in collagen-induced arthritis (CIA). In this study, it was investigated whether a single transfer of polyclonally activated T(reg) cells inhibits CIA and osteoclastogenesis...
- Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice
M G Anderson
The Howard Hughes Medical Institute, Bar Harbor, Maine, USA
BMC Genet 2:1. 2001
..The purpose of this study was to determine if the effects of the DBA/2J derived isa and ipd loci are modified in strain AKXD-28/Ty...
- The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies
J K Belknap
Research Service R and D5, Department of Veterans Affairs Medical Center, Portland Alcohol Research Center, and Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, Oregon 97201, USA
Mamm Genome 12:893-9. 2001
..Two other QTLs on Chrs 1 (distal) and 11 (mid) were less consistent, but still reached overall significance (P <.0001)...
- Variants of kappa-opioid receptor gene and mRNA in alcohol-preferring and alcohol-avoiding mice
Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
Alcohol 29:39-49. 2003
..The strain-dependent variation in the expression of alternatively spliced genes can be a significant source of phenotypic variation of complex traits such as alcohol preference...
- Optic nerve degeneration in the DBA/2NNia mouse: is the lamina cribrosa important in the development of glaucomatous optic neuropathy?
Christian Albrecht May
Department of Anatomy, Carl Gustav Carus Medical Faculty, TU Dresden, Dresden, Germany
Acta Neuropathol 111:158-67. 2006
..In addition, astrocytes in the ON head form extracellular material similar to that found in human glaucomatous eyes...
- Clinical and immunomodulatory effects of fun-boi, an herbal medicine, on collagen-induced arthritis in vivo
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
Clin Exp Rheumatol 21:57-62. 2003
..The objective of this study was therefore to evaluate the efficacy of Fun-boi against arthritis and its effect on the immune system...
- Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Exp Med 197:1297-302. 2003
..These data demonstrate the critical role of cPLA2alpha in the pathogenesis of CIA...
- Effective antiprotease-antibiotic treatment of experimental anthrax
Serguei G Popov
Advanced Biosystems, Inc, Manassas, VA, USA
BMC Infect Dis 5:25. 2005
..anthracis distinct from lethal toxin...
- Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma
Denise M Inman
Harborview Research and Training, Department of Neurosurgery, University of Washington, Seattle, Washington 98104, USA
Invest Ophthalmol Vis Sci 47:986-96. 2006
..To investigate quantitatively the relationships between elevated intraocular pressure (IOP), axonal loss, and corneal thickness in the DBA/2 mouse model of glaucoma, to understand better how these factors contribute to disease progression...
- Organ-specific disease provoked by systemic autoimmunity
Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
Cell 87:811-22. 1996
..We suggest that human RA develops by an analogous mechanism...
- Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade
Julia J Inglis
Kennedy Institute of Rheumatology, Imperial College London, London, UK
Arthritis Rheum 56:4015-23. 2007
..We then validated the model using anti-tumor necrosis factor (anti-TNF) therapy, which has analgesic effects in models of inflammation as well as in human RA...
- Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice
Veronica V Colinayo
Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California 90095, USA
Mamm Genome 14:464-71. 2003
..In this intercross, the genes primarily influencing atherosclerosis are distinct from those controlling plasma lipid levels...
- The pattern electroretinogram as a tool to monitor progressive retinal ganglion cell dysfunction in the DBA/2J mouse model of glaucoma
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Invest Ophthalmol Vis Sci 48:745-51. 2007
- Effects of cigarette smoke in mice with different levels of alpha(1)-proteinase inhibitor and sensitivity to oxidants
Dipartimento di Fisiopatologia e Medicina Sperimentale, , Siena, Italy
Am J Respir Crit Care Med 164:886-90. 2001
..All these results indicate that sensitivity to the effects of cigarette smoke is strain-dependent and cigarette smoke accelerates the effects of alpha(1)-PI deficiency...
- Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
R N Kulkarni
Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Cell 96:329-39. 1999
- New replicable anxiety-related measures of wall vs center behavior of mice in the open field
Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel 69978
J Appl Physiol (1985) 97:347-59. 2004
..The entire set of end points can be used on various genetic and pharmacological models of anxiety with good prospects of providing fine discrimination in a replicable manner...
- IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis
Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St Radboud, Nijmegen, The Netherlands
J Immunol 167:1004-13. 2001
..These findings suggest IL-17 to be a novel target for the treatment of destructive arthritis and may have implications for tissue destruction in other autoimmune diseases...
- Potent adjuvant effect by anti-CD40 in collagen-induced arthritis. Enhanced disease is accompanied by increased production of collagen type-II reactive IgG2a and IFN-gamma
A C Tellander
Active Biotech Research AB, Lund, Sweden
J Autoimmun 14:295-302. 2000
..In conclusion, our results indicate that the level of CD40 activation during the induction of an autoimmune response may determine the severity of the resulting disease...
- Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
Serono Pharmaceutical Research Institute, Serono International S A, 14, Chemin des Aulx, 1228 Plan les Ouates, Geneva, Switzerland
Nat Med 11:936-43. 2005
..Our results identify selective PI3Kgamma inhibitors as potential therapeutic molecules for the treatment of chronic inflammatory disorders such as rheumatoid arthritis...
- Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFalpha, anti-IL-1alpha/beta and IL-1Ra
Leo A B Joosten
University Hospital Nijimegen, Nijimegen, The Netherlands
Arthritis Rheum 58:S110-22. 2008
..To examine the role of tumor necrosis factor alpha (TNF alpha), interleukin-1 alpha (IL-1 alpha), and IL-1 beta in collagen-induced arthritis (CIA), immediately after onset and during the phase of established arthritis...
- Differential T cell costimulatory requirements in CD28-deficient mice
Department of Medical Biophysics and Immunology, University of Toronto, Canada
Science 261:609-12. 1993
..Thus, CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist...
- A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice
Kim W McIntyre
Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
Arthritis Rheum 48:2652-9. 2003
- Effects of repeated maternal separation on prepulse inhibition of startle across inbred mouse strains
R A Millstein
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, MD 20852, USA
Genes Brain Behav 5:346-54. 2006
..The development and validation of a reliable mouse model of early life stress remains an important research goal...
- Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice
Adrianus C M Boon
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Virol 83:10417-26. 2009
..One of the validated genes, the hemolytic complement gene, affected virus titer 7 days after infection. We conclude that H5N1 influenza virus-induced pathology is affected by a complex and multigenic host component...
- IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic joints
C Q Chu
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
Ann Rheum Dis 62:983-90. 2003
..Transgenic deficiency in interferon gamma (IFNgamma) or IFNgamma receptor makes resistant strains of mice bearing H-2(b) or H-2(d) susceptible to collagen induced arthritis (CIA)...
- Interleukin 6 is required for the development of collagen-induced arthritis
Istituto Ricerche di Biologia Molecolare P Angeletti, 00040 Pomezia, Rome, Italy
J Exp Med 187:461-8. 1998
..These results are discussed in the light of the present knowledge of cytokine networks in chronic inflammatory disorders and suggest that IL-6 receptor antagonists might be beneficial for the treatment of RA...
- Genetic variation in morphine analgesic tolerance: a survey of 11 inbred mouse strains
Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, Staten Island, NY 10314, USA
Pharmacol Biochem Behav 73:821-8. 2002
..The present work demonstrates that the presence and magnitude of morphine analgesic tolerance is genotype-dependent and identifies strains with widely divergent liabilities that should facilitate identification of trait-relevant genes...
- Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis
Department of Oncology, Biology, and Genetics, University of Genoa, National Institute for Cancer Research, Genoa, Italy
Arthritis Rheum 56:1175-86. 2007
..We explored the feasibility of using allogeneic MSCs as therapy for collagen-induced arthritis, a mouse model for human rheumatoid arthritis...
- The polarization of T(h)1/T(h)2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production
Basic Research Laboratories, Ajinomoto Co Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 0861, Japan
Int Immunol 14:201-12. 2002
..The findings implicate that the alteration in Mp functions because altered intracellular glutathione may play a relevant role in the pathological progression of inflammation...
- Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer
Center for Developmental Biology, RIKEN Kobe, Japan
J Reprod Dev 53:165-70. 2007
- Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet
University of Melbourne, Department of Medicine, Heidelberg Repatriation Hospital, Heidelberg Heights, Victoria 3081, Australia
J Endocrinol 187:45-53. 2005
..Understanding these differences will provide researchers with the information to choose the appropriate genetic background on which to express their particular genetic alteration...
- Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine
Max Planck Institute of Psychiatry, 80804 Munich, Germany
Psychopharmacology (Berl) 200:557-72. 2008
..Monoamine-based antidepressants inhibit neurotransmitter reuptake within short time. However, it commonly takes several weeks until clinical symptoms start to resolve--indicating the involvement of effects distant from reuptake inhibition...
- Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate
J C Bowman
Department of Human and Animal Infectious Disease Research, Merck Research Laboratories, Rahway, New Jersey 07065-0900, USA
Antimicrob Agents Chemother 45:3474-81. 2001
- Mapping the genetic architecture of complex traits in experimental populations
Institute of Bioinformatics, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, PR China
Bioinformatics 23:1527-36. 2007
..Two real-world phenotypes (BXD mouse olfactory bulb weight data and rice yield data) are used as exemplars to demonstrate our methods. AVAILABILITY: A software package is freely available at http://ibi.zju.edu.cn/software/qtlnetwork..
- Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis
J M Metselaar
Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, The Netherlands
Ann Rheum Dis 63:348-53. 2004
- Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen-induced arthritis
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Arthritis Rheum 58:3742-52. 2008
- Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice
K E Browman
Portland Alcohol Research Center, Department of Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, 97201, USA
Alcohol Clin Exp Res 24:17-23. 2000
..Many QTL analyses have been performed in BXD recombinant inbred (RI) strains of mice derived from a cross of C57BL/6J (B6) and DBA/2J (D2) progenitor strains...
- Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice
Robnet T Kerns
Department of Pharmacology Toxicology and the Center for Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia 23298, USA
J Neurosci 25:2255-66. 2005
..Brain region-specific changes in signaling and neuronal plasticity may be critical components in development of lasting ethanol behavioral phenotypes such as dependence, sensitization, and craving...
- Gene expression differences in mice divergently selected for methamphetamine sensitivity
Abraham A Palmer
Columbia Genome Center, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
Mamm Genome 16:291-305. 2005
..The identified genes provide excellent candidates for future hypothesis-driven studies, translational genetic studies, and pharmacological interventions...
- Using gene expression databases for classical trait QTL candidate gene discovery in the BXD recombinant inbred genetic reference population: mouse forebrain weight
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, PR China
BMC Genomics 9:444. 2008
..We also required verification of mRNA abundance by an independent method, and finally we required either differences in protein levels or confirmed DNA sequence differences...
- Adrenalectomy prevents behavioural sensitisation of mice to cocaine in a genotype-dependent manner
Inge E M de Jong
Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, Division of Medical Pharmacology, Gorlaeus Laboratories, Einsteinweg 55, P O Box 9502, 2300 RA Leiden, The Netherlands
Behav Brain Res 177:329-39. 2007
..The present results demonstrate that adrenal stress hormones facilitate behavioural sensitisation to cocaine in a genotype-dependent manner and suggest that glucocorticoids contribute to strain differences in psychostimulant sensitivity...
- Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma
Department of Ophthalmology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Dev Neurobiol 67:603-16. 2007
..These findings suggest the possible involvement of multiple biochemical events, including estrogen receptor/Akt/CREB/thioredoxin-1, and estrogen receptor/MAPK/NF-kappaB, in estrogen-mediated retinal ganglion cell protection...
- Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease
Department Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
Nat Med 7:563-8. 2001
..The therapeutic effect of VIP was associated with downregulation of both inflammatory and autoimmune components of the disease. Our data indicate VIP as a viable candidate for the development of treatments for RA...
- By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma
Jun Song Mo
The Howard Hughes Medical Institute, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
J Exp Med 197:1335-44. 2003
..These results suggest previously unsuspected roles for bone marrow-derived cells and ocular immune privilege in the pathogenesis of PG...
- A new set of BXD recombinant inbred lines from advanced intercross populations in mice
Jeremy L Peirce
Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA
BMC Genet 5:7. 2004
..elegans, and Drosophila, mouse RI panels typically consist of fewer than 30 lines. This is a severe constraint on the power and precision of mapping efforts and greatly hampers analysis of epistatic interactions...
- Quantitative analysis of retinal ganglion cell (RGC) loss in aging DBA/2NNia glaucomatous mice: comparison with RGC loss in aging C57/BL6 mice
Department of Ophthalmology, Mount Sinai School of Medicine, Mount Sinai Medical Center, 1 Gustave L Levy Place, New York, NY 10029, USA
Invest Ophthalmol Vis Sci 44:5151-62. 2003
..To quantify the extent and pattern of retinal ganglion cell (RGC) loss in the DBA2/NNia glaucomatous mouse strain as a function of age and compare it with ganglion cell loss in a nonglaucomatous strain...
- Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence
Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, 10314, USA
Neuroscience 115:463-9. 2002
..The data also demonstrate that the differential genetic liability to morphine physical dependence begins with, and is predicted by, the first morphine exposure...
- Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis
Amgen Institute, Ontario Cancer Institute, Ontario, Canada
J Immunol 156:4520-6. 1996
- IL-6 inhibits the tolerogenic function of CD8 alpha+ dendritic cells expressing indoleamine 2,3-dioxygenase
Department of Experimental Medicine, University of Perugia, Via del Giochetto, I 06122 Perugia, Italy
J Immunol 167:708-14. 2001
..The activity of IL-6 includes down-regulation of IFN-gammaR expression in the CD8(+) DC subset and correlates to a reduced ability of these cells to metabolize tryptophan and initiate T cell apoptosis in vitro...
- What do comparative studies of inbred mice add to current investigations on the neural basis of spatial behaviors?
Dipartimento di Psicologia, Rome, Italy
Exp Brain Res 123:36-44. 1998
..The data highlight the variability in the neural mechanisms subserving well-differentiated levels of spatial performance. The contribution of inbred mice to our general understanding of the neural basis of spatial cognition is discussed...
- Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
Deborah A Young
Wyeth Research, Cambridge, Massachusetts 02140, USA
Arthritis Rheum 56:1152-63. 2007
..In this study, the effects of blocking IL-21 were examined in 2 rodent models of rheumatoid arthritis (RA) to determine whether IL-21 contributes to their pathologic processes...
- Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes
Department of Psychiatry, SUNY at Stony Brook, NY 11794 8101, USA
Alcohol Clin Exp Res 27:1-11. 2003
- Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice
F O Risinger
Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health Sciences University, 97201 3098, USA
Alcohol Clin Exp Res 22:1234-44. 1998
..Some of these genes appear to influence taste sensitivity, whereas others appear to mediate sensitivity to aversive pharmacological effects of ethanol...
- Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains
J K Belknap
Research Service 151W, VA Med Ctr, Portland, OR 97201, USA
Life Sci 57:PL117-24. 1995
- Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies
A M Malfait
Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, UK
Arthritis Rheum 44:1215-24. 2001
..CONCLUSION: Chronic relapsing homologous collagen-induced arthritis is a valuable model for identifying remission-inducing antiarthritic drugs and has predictive value with respect to their joint-protective potency...
- M-1/M-2 macrophages and the Th1/Th2 paradigm
C D Mills
Department of Surgery, University of Minnesota, Minneapolis 55455, USA
J Immunol 164:6166-73. 2000
..Together, the results indicate that M-1- or M-2-dominant macrophage responses can influence whether Th1/Th2 or other types of inflammatory responses occur...
- Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma
Michael R Steele
Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah 84132, USA
Invest Ophthalmol Vis Sci 47:977-85. 2006
..The study was undertaken to correlate changes in retinal gene expression with IOP elevation by performing microarray analysis of retinal RNA from DBA/2J mice at 3 months before disease onset and at 8 months after IOP elevation...
- Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB
Kutty Selva Nandakumar
Medical Inflammation Research, Biomedical Center, Lund University, Lund, Sweden
Eur J Immunol 33:2269-77. 2003
..These results demonstrate that single IgG anti-CII mAb can induce erosive arthritis and that IgG anti-CII Ab mediate arthritis by engagement of FcgammaR...
- Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells
Manuel A Gonzalez
Cellerix SA, Tres Cantos, and Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, Madrid, Spain
Arthritis Rheum 60:1006-19. 2009
..The purpose of this study was to examine a new therapeutic strategy for RA based on the administration of human adipose-derived MSCs (AD-MSCs)...
- Gene-expression profile of collagen-induced arthritis
Saleh Mohamed Ibrahim
Institute of Immunology, University of Rostock, Schillingallee 70, Rostock, 18055, Germany
J Autoimmun 18:159-67. 2002
..The profile of gene expression supports current theoretical models of disease progression and might open new perspectives for both diagnosis and treatment of arthritis...
- Localized expression of an anti-TNF single-chain antibody prevents development of collagen-induced arthritis
Baxter Laboratory for Genetic Pharmacology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94304, USA
Gene Ther 10:1248-57. 2003
..This is encouraging for the potential development of safe adoptive cellular therapies to treat autoimmunity...
- Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18
X Q Wei
Department of Immunology and Bacteriology, University of Glasgow, Glasgow, G11 6NT, United Kingdom
J Immunol 166:517-21. 2001
..These data directly demonstrate a pivotal role of IL-18 in the development of inflammatory arthritis and suggest that antagonists to IL-18 may have therapeutic potential in rheumatic diseases...
- Differential change in neuroactive steroid sensitivity during ethanol withdrawal
D A Finn
Portland Alcohol Research Center, Research Service, Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, OR 97201, USA
J Pharmacol Exp Ther 292:394-405. 2000
..These results suggest that sensitization to the anticonvulsant effect of 3alpha,5alpha-P during EtOH withdrawal does not generalize across all genotypes nor does it generalize to all of the pharmacological effects of 3alpha,5alpha-P...
- Variation in mouse basolateral amygdala volume is associated with differences in stress reactivity and fear learning
Rebecca J Yang
Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852 9411, USA
Neuropsychopharmacology 33:2595-604. 2008
- Role of cyclooxygenase-2, but not cyclooxygenase-1, on type II collagen-induced arthritis in DBA/1J mice
Department of Immunology and Inflammation, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, 1 6, Kashima 2 chome, Yodogawa ku, Osaka 532 8514, Japan
Biochem Pharmacol 66:1055-60. 2003
..20 and 0.12 mg/kg, respectively, similar to indomethacin. In contrast, FR122047 and SC-560 had no effect. These results suggest that COX-2, but not COX-1, contributes to the edema and the formation of PGE(2) and TXB(2) in mouse CIA model...
- Changes in retinal neuronal populations in the DBA/2J mouse
Jung Il Moon
Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul, 137 701, Korea
Cell Tissue Res 320:51-9. 2005
..Thus, the D2 mouse retina represents a useful model for studying the pathogenesis of glaucoma and mechanisms of retinal neuronal death and for evaluating neuroprotection strategies...