inbred dba mice

Summary

Top Publications

  1. ncbi Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration
    Richard T Libby
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Vis Neurosci 22:637-48. 2005
  2. pmc Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice
    Tatjana C Jakobs
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114
    J Cell Biol 171:313-25. 2005
  3. pmc Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)
    Wei Li
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Genet 35:84-9. 2003
  4. ncbi Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma
    Xiaohong Zhou
    Department of Ophthalmology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 280:31240-8. 2005
  5. ncbi Genetics of gene expression surveyed in maize, mouse and man
    Eric E Schadt
    Rosetta Inpharmatics, LLC, 12040 115th Avenue N E, Kirkland, Washington 98034, USA
    Nature 422:297-302. 2003
  6. pmc High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 102:4566-71. 2005
  7. ncbi Metabolic adaptations of three inbred strains of mice (C57BL/6, DBA/2, and 129T2) in response to a high-fat diet
    Alexandra Funkat
    The University of Melbourne, Department of Medicine, AH NH, Heidelberg Repatriation Hospital, Heidelberg Heights, Victoria 3081 Australia
    J Nutr 134:3264-9. 2004
  8. ncbi CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis
    Mary E Morgan
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 48:1452-60. 2003
  9. pmc Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Genetics 172:1783-97. 2006
  10. ncbi Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer
    S Tanaka
    Laboratory of Cellular Biochemistry, Animal Resource Sciences/Veterinary Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
    Biol Reprod 65:1813-21. 2001

Research Grants

Detail Information

Publications271 found, 100 shown here

  1. ncbi Inherited glaucoma in DBA/2J mice: pertinent disease features for studying the neurodegeneration
    Richard T Libby
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Vis Neurosci 22:637-48. 2005
    ..This information should help with the design of experiments, and we present the data in a manner that will be useful for future studies of retinal ganglion cell degeneration and optic neuropathy...
  2. pmc Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice
    Tatjana C Jakobs
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114
    J Cell Biol 171:313-25. 2005
    ..However, the architecture of the mouse eye seems to preclude a commonly postulated source of mechanical damage within the nerve head...
  3. pmc Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)
    Wei Li
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Genet 35:84-9. 2003
    ....
  4. ncbi Involvement of inflammation, degradation, and apoptosis in a mouse model of glaucoma
    Xiaohong Zhou
    Department of Ophthalmology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 280:31240-8. 2005
    ..The possibility that altered IL-18 expression in the eye of DBA/2J mice initiates and/or amplifies the pathogenesis of pigmentary glaucoma requires further investigation...
  5. ncbi Genetics of gene expression surveyed in maize, mouse and man
    Eric E Schadt
    Rosetta Inpharmatics, LLC, 12040 115th Avenue N E, Kirkland, Washington 98034, USA
    Nature 422:297-302. 2003
    ..We identify a gene expression pattern strongly associated with obesity in a murine cross, and observe two distinct obesity subtypes. Furthermore, we find that these obesity subtypes are under the control of different loci...
  6. pmc High-dose radiation with bone marrow transfer prevents neurodegeneration in an inherited glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 102:4566-71. 2005
    ..Because of the robust protective effect, this treatment offers another tool for studying mechanisms of neuroprotection...
  7. ncbi Metabolic adaptations of three inbred strains of mice (C57BL/6, DBA/2, and 129T2) in response to a high-fat diet
    Alexandra Funkat
    The University of Melbourne, Department of Medicine, AH NH, Heidelberg Repatriation Hospital, Heidelberg Heights, Victoria 3081 Australia
    J Nutr 134:3264-9. 2004
    ..It further highlights that the background strain used to produce genetically modified mice is critical to the resultant phenotype...
  8. ncbi CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis
    Mary E Morgan
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 48:1452-60. 2003
    ..We wished to evaluate their potential for influencing systemic and chronic joint inflammation by investigating their involvement in collagen-induced arthritis (CIA)...
  9. pmc Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Genetics 172:1783-97. 2006
    ..However, even with a very large panel of RILs, mapping resolution may not be sufficient to identify single genes unambiguously. Our results are generally applicable to the design of RILs in other species...
  10. ncbi Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer
    S Tanaka
    Laboratory of Cellular Biochemistry, Animal Resource Sciences/Veterinary Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
    Biol Reprod 65:1813-21. 2001
    ..Thus, a major cause of placentomegaly is expansion of the spongiotrophoblast layer, which consequently disturbs the architecture of the layers in the placenta and partially damages its function...
  11. ncbi Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagen
    D Plows
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Immunol 162:1018-23. 1999
    ..We conclude that adaptive immune responses are not the only arthritogenic mechanism and hypothesize that the nonantigenic properties of type II collagen can also lead to arthritis...
  12. ncbi An integrative genomics approach to the reconstruction of gene networks in segregating populations
    J Zhu
    Rosetta Inpharmatics, Seattle, WA, USA
    Cytogenet Genome Res 105:363-74. 2004
    ....
  13. ncbi Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    Erik Lubberts
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:650-9. 2004
    ..This T cell cytokine is implicated in the initiation phase of arthritis. However, the role of IL-17 during the effector phase of arthritis has still not been identified; this was the objective of the present study...
  14. pmc An integrative genomics approach to infer causal associations between gene expression and disease
    Eric E Schadt
    Rosetta Inpharmatics, Seattle, Washington 98109, USA
    Nat Genet 37:710-7. 2005
    ..We also demonstrate the utility of this approach by identifying and experimentally validating the involvement of three new genes in susceptibility to obesity...
  15. ncbi Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis
    Yoshinaga Ito
    Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Arthritis Rheum 60:2294-303. 2009
    ..The involvement of IL-17-producing gamma/delta T cells in SKG mice with autoimmune arthritis and patients with rheumatoid arthritis (RA) was also investigated...
  16. pmc Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors
    S Kleinau
    Department of Genetics and Pathology, Uppsala University, S 75185 Uppsala, Sweden
    J Exp Med 191:1611-6. 2000
    ..In comparison, DBA/1 mice lacking FcgammaRII developed an augmented IgG anticollagen response and arthritis. These observations suggest a crucial role of FcgammaRI and FcgammaRIII in triggering autoimmune arthritis...
  17. ncbi T2Rs function as bitter taste receptors
    J Chandrashekar
    Howard Hughes Medical Institute and Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Cell 100:703-11. 2000
    ..Since a single taste receptor cell expresses a large repertoire of T2Rs, these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds...
  18. pmc Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric
    Cassandra L Schlamp
    Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI, USA
    BMC Neurosci 7:66. 2006
    ....
  19. pmc The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria
    Xiaoxin X Wang
    Department of Medicine, University of Colorado Denver, and Veterans Affairs Medical Center, Aurora, Colorado, USA
    Am J Physiol Renal Physiol 297:F1587-96. 2009
    ....
  20. pmc Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis
    T Kasama
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    J Clin Invest 95:2868-76. 1995
    ..These data suggest that MIP-1 alpha and MIP-2 play a crucial role in the initiation and maintenance, while IL-10 appears to play a regulatory role during the development of experimental arthritis...
  21. pmc PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models
    Rong Hai
    Department of Microbiology, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029 6574, USA
    J Virol 84:4442-50. 2010
    ..In summary, our study demonstrates that PB1-F2 expression by the Cal/09 virus modulates the immune response to infection while having a minimal effect on virus virulence in two mammalian models...
  22. pmc Genetic context determines susceptibility to intraocular pressure elevation in a mouse pigmentary glaucoma
    Michael G Anderson
    The Jackson Laboratory, Bar Harbor, ME, USA
    BMC Biol 4:20. 2006
    ..We initiated a study of congenic strains to further define the genetic requirements and disease mechanisms of the D2 glaucoma...
  23. ncbi Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice
    Michael G Anderson
    The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
    Nat Genet 30:81-5. 2002
    ..The fact that hypopigmentation profoundly alleviates the D2 disease indicates that therapeutic strategies designed to decrease pigment production may be beneficial in human pigmentary glaucoma...
  24. pmc The genetic control of neocortex volume and covariation with neocortical gene expression in mice
    Shiv M Gaglani
    Department of Neurology, Division of Behavioral Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    BMC Neurosci 10:44. 2009
    ..Here we use unbiased stereological techniques to map quantitative trait loci (QTLs) that modulate the volume of neocortex...
  25. ncbi Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice
    Edward S Brodkin
    Department of Psychiatry, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Room 111, Philadelphia, PA 19104 6140, USA
    Brain Res 1002:151-7. 2004
    ..Thus, this phenotype is affected by spontaneous genetic variation in mice and can be measured in an assay useful for future neurogenetic studies...
  26. pmc Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains
    Sheryl S Moy
    North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 176:4-20. 2007
    ..Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses...
  27. ncbi B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells
    Yi Ling Hu
    Department of Inflammation, Amgen, Inc, Thousand Oaks, CA 91320, USA
    J Immunol 182:1421-8. 2009
    ..These findings further support the role of ICOS in autoimmunity and suggest that the expansion of the T(FH) cell pool is an important mechanism by which ICOS regulates Ab production...
  28. ncbi Synergistic protection against cartilage destruction by low dose prednisolone and interleukin-10 in established murine collagen arthritis
    L A Joosten
    Department of Rheumatology, University Hospital Nijmegen, The Netherlands
    Inflamm Res 48:48-55. 1999
    ..To investigate potential synergy of low dosages glucocorticosteroids (GC's) and interleukin-10 (IL-10), using established murine collagen-induced arthritis (CIA) as a model...
  29. ncbi Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection
    Jonathan Zalevsky
    Xencor, Monrovia, CA 91016, USA
    J Immunol 179:1872-83. 2007
    ....
  30. ncbi Gene therapy targeting the Tie2 function ameliorates collagen-induced arthritis and protects against bone destruction
    Ying Chen
    Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Arthritis Rheum 52:1585-94. 2005
    ..The current study was performed to determine whether systemic delivery of a soluble Tie2 receptor (ExTek) using an adenoviral vector (AdExTek) as a Tie2 inhibitor affects arthritis development and progression in an animal model...
  31. ncbi The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF
    I K Campbell
    Inflammation Research Centre, The University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Leukoc Biol 68:144-50. 2000
    ..Our results also show that M-CSF-dependent cells are essential for CIA development, suggesting M-CSF may be a suitable target for therapeutic intervention in RA...
  32. ncbi DNA methylation errors in cloned mice disappear with advancement of aging
    Sho Senda
    Laboratory of Cellular Biochemistry, Animal Resource Sciences Veterinary Medical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Cloning Stem Cells 9:293-302. 2007
    ..Interestingly, we could detect only one aberrantly methylated locus in two of the three adult clones in mid-age and none of four senescent clones, indicating that errors in DNA methylation disappear with advancement of animals' aging...
  33. ncbi Altered expression of skeletal muscle myosin isoforms in cancer cachexia
    Gary M Diffee
    Biodynamics Laboratory, University of Wisconsin, Madison, Wisconsin 53706, USA
    Am J Physiol Cell Physiol 283:C1376-82. 2002
    ..MHC isoform content was not significantly different from control in plantaris and gastrocnemius muscles. These data are the first to show a change in myosin isoform expression accompanying muscle atrophy during cancer cachexia...
  34. ncbi Trypanosoma cruzi: role of host genetic background in the differential tissue distribution of parasite clonal populations
    Luciana O Andrade
    Departamento de Bioquimica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270 901 MG, Brazil
    Exp Parasitol 100:269-75. 2002
    ....
  35. pmc Genomic analysis of metabolic pathway gene expression in mice
    Anatole Ghazalpour
    Department of Human Genetics, Molecular Biology Institute, University of California, Los Angeles, CA 90095 1679, USA
    Genome Biol 6:R59. 2005
    ..Quantitative trait locus analyses were applied to the subcutaneous fat-mass trait and all gene-expression data. These data were then used to identify gene sets that are differentially perturbed in lean and obese mice...
  36. ncbi Activated CD4+CD25+ regulatory T cells inhibit osteoclastogenesis and collagen-induced arthritis
    H Kelchtermans
    Laboratory of Immunobiology, Rega Institute, Leuven, Belgium
    Ann Rheum Dis 68:744-50. 2009
    ..A similar situation has been described in collagen-induced arthritis (CIA). In this study, it was investigated whether a single transfer of polyclonally activated T(reg) cells inhibits CIA and osteoclastogenesis...
  37. pmc Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice
    M G Anderson
    The Howard Hughes Medical Institute, Bar Harbor, Maine, USA
    BMC Genet 2:1. 2001
    ..The purpose of this study was to determine if the effects of the DBA/2J derived isa and ipd loci are modified in strain AKXD-28/Ty...
  38. ncbi The replicability of QTLs for murine alcohol preference drinking behavior across eight independent studies
    J K Belknap
    Research Service R and D5, Department of Veterans Affairs Medical Center, Portland Alcohol Research Center, and Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mamm Genome 12:893-9. 2001
    ..Two other QTLs on Chrs 1 (distal) and 11 (mid) were less consistent, but still reached overall significance (P <.0001)...
  39. ncbi Variants of kappa-opioid receptor gene and mRNA in alcohol-preferring and alcohol-avoiding mice
    Mariko Saito
    Laboratory of Neurobehavior Genetics, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Alcohol 29:39-49. 2003
    ..The strain-dependent variation in the expression of alternatively spliced genes can be a significant source of phenotypic variation of complex traits such as alcohol preference...
  40. ncbi Optic nerve degeneration in the DBA/2NNia mouse: is the lamina cribrosa important in the development of glaucomatous optic neuropathy?
    Christian Albrecht May
    Department of Anatomy, Carl Gustav Carus Medical Faculty, TU Dresden, Dresden, Germany
    Acta Neuropathol 111:158-67. 2006
    ..In addition, astrocytes in the ON head form extracellular material similar to that found in human glaucomatous eyes...
  41. ncbi Clinical and immunomodulatory effects of fun-boi, an herbal medicine, on collagen-induced arthritis in vivo
    A Niizawa
    Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Clin Exp Rheumatol 21:57-62. 2003
    ..The objective of this study was therefore to evaluate the efficacy of Fun-boi against arthritis and its effect on the immune system...
  42. pmc Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis
    Martin Hegen
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Exp Med 197:1297-302. 2003
    ..These data demonstrate the critical role of cPLA2alpha in the pathogenesis of CIA...
  43. pmc Effective antiprotease-antibiotic treatment of experimental anthrax
    Serguei G Popov
    Advanced Biosystems, Inc, Manassas, VA, USA
    BMC Infect Dis 5:25. 2005
    ..anthracis distinct from lethal toxin...
  44. ncbi Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma
    Denise M Inman
    Harborview Research and Training, Department of Neurosurgery, University of Washington, Seattle, Washington 98104, USA
    Invest Ophthalmol Vis Sci 47:986-96. 2006
    ..To investigate quantitatively the relationships between elevated intraocular pressure (IOP), axonal loss, and corneal thickness in the DBA/2 mouse model of glaucoma, to understand better how these factors contribute to disease progression...
  45. ncbi Organ-specific disease provoked by systemic autoimmunity
    V Kouskoff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
    Cell 87:811-22. 1996
    ..We suggest that human RA develops by an analogous mechanism...
  46. ncbi Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 56:4015-23. 2007
    ..We then validated the model using anti-tumor necrosis factor (anti-TNF) therapy, which has analgesic effects in models of inflammation as well as in human RA...
  47. ncbi Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in mice
    Veronica V Colinayo
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California 90095, USA
    Mamm Genome 14:464-71. 2003
    ..In this intercross, the genes primarily influencing atherosclerosis are distinct from those controlling plasma lipid levels...
  48. pmc The pattern electroretinogram as a tool to monitor progressive retinal ganglion cell dysfunction in the DBA/2J mouse model of glaucoma
    Vittorio Porciatti
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 48:745-51. 2007
    ....
  49. ncbi Effects of cigarette smoke in mice with different levels of alpha(1)-proteinase inhibitor and sensitivity to oxidants
    E Cavarra
    Dipartimento di Fisiopatologia e Medicina Sperimentale, , Siena, Italy
    Am J Respir Crit Care Med 164:886-90. 2001
    ..All these results indicate that sensitivity to the effects of cigarette smoke is strain-dependent and cigarette smoke accelerates the effects of alpha(1)-PI deficiency...
  50. ncbi Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    R N Kulkarni
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell 96:329-39. 1999
    ....
  51. ncbi New replicable anxiety-related measures of wall vs center behavior of mice in the open field
    Dina Lipkind
    Department of Zoology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel 69978
    J Appl Physiol (1985) 97:347-59. 2004
    ..The entire set of end points can be used on various genetic and pharmacological models of anxiety with good prospects of providing fine discrimination in a replicable manner...
  52. ncbi IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis
    E Lubberts
    Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 167:1004-13. 2001
    ..These findings suggest IL-17 to be a novel target for the treatment of destructive arthritis and may have implications for tissue destruction in other autoimmune diseases...
  53. ncbi Potent adjuvant effect by anti-CD40 in collagen-induced arthritis. Enhanced disease is accompanied by increased production of collagen type-II reactive IgG2a and IFN-gamma
    A C Tellander
    Active Biotech Research AB, Lund, Sweden
    J Autoimmun 14:295-302. 2000
    ..In conclusion, our results indicate that the level of CD40 activation during the induction of an autoimmune response may determine the severity of the resulting disease...
  54. ncbi Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
    Montserrat Camps
    Serono Pharmaceutical Research Institute, Serono International S A, 14, Chemin des Aulx, 1228 Plan les Ouates, Geneva, Switzerland
    Nat Med 11:936-43. 2005
    ..Our results identify selective PI3Kgamma inhibitors as potential therapeutic molecules for the treatment of chronic inflammatory disorders such as rheumatoid arthritis...
  55. ncbi Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFalpha, anti-IL-1alpha/beta and IL-1Ra
    Leo A B Joosten
    University Hospital Nijimegen, Nijimegen, The Netherlands
    Arthritis Rheum 58:S110-22. 2008
    ..To examine the role of tumor necrosis factor alpha (TNF alpha), interleukin-1 alpha (IL-1 alpha), and IL-1 beta in collagen-induced arthritis (CIA), immediately after onset and during the phase of established arthritis...
  56. ncbi Differential T cell costimulatory requirements in CD28-deficient mice
    A Shahinian
    Department of Medical Biophysics and Immunology, University of Toronto, Canada
    Science 261:609-12. 1993
    ..Thus, CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist...
  57. ncbi A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice
    Kim W McIntyre
    Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA
    Arthritis Rheum 48:2652-9. 2003
    ....
  58. ncbi Effects of repeated maternal separation on prepulse inhibition of startle across inbred mouse strains
    R A Millstein
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, MD 20852, USA
    Genes Brain Behav 5:346-54. 2006
    ..The development and validation of a reliable mouse model of early life stress remains an important research goal...
  59. pmc Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice
    Adrianus C M Boon
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Virol 83:10417-26. 2009
    ..One of the validated genes, the hemolytic complement gene, affected virus titer 7 days after infection. We conclude that H5N1 influenza virus-induced pathology is affected by a complex and multigenic host component...
  60. pmc IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic joints
    C Q Chu
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Ann Rheum Dis 62:983-90. 2003
    ..Transgenic deficiency in interferon gamma (IFNgamma) or IFNgamma receptor makes resistant strains of mice bearing H-2(b) or H-2(d) susceptible to collagen induced arthritis (CIA)...
  61. pmc Interleukin 6 is required for the development of collagen-induced arthritis
    T Alonzi
    Istituto Ricerche di Biologia Molecolare P Angeletti, 00040 Pomezia, Rome, Italy
    J Exp Med 187:461-8. 1998
    ..These results are discussed in the light of the present knowledge of cytokine networks in chronic inflammatory disorders and suggest that IL-6 receptor antagonists might be beneficial for the treatment of RA...
  62. ncbi Genetic variation in morphine analgesic tolerance: a survey of 11 inbred mouse strains
    Benjamin Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, Staten Island, NY 10314, USA
    Pharmacol Biochem Behav 73:821-8. 2002
    ..The present work demonstrates that the presence and magnitude of morphine analgesic tolerance is genotype-dependent and identifies strains with widely divergent liabilities that should facilitate identification of trait-relevant genes...
  63. ncbi Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis
    Andrea Augello
    Department of Oncology, Biology, and Genetics, University of Genoa, National Institute for Cancer Research, Genoa, Italy
    Arthritis Rheum 56:1175-86. 2007
    ..We explored the feasibility of using allogeneic MSCs as therapy for collagen-induced arthritis, a mouse model for human rheumatoid arthritis...
  64. ncbi The polarization of T(h)1/T(h)2 balance is dependent on the intracellular thiol redox status of macrophages due to the distinctive cytokine production
    Yukie Murata
    Basic Research Laboratories, Ajinomoto Co Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 0861, Japan
    Int Immunol 14:201-12. 2002
    ..The findings implicate that the alteration in Mp functions because altered intracellular glutathione may play a relevant role in the pathological progression of inflammation...
  65. ncbi Successful mouse cloning of an outbred strain by trichostatin A treatment after somatic nuclear transfer
    Satoshi Kishigami
    Center for Developmental Biology, RIKEN Kobe, Japan
    J Reprod Dev 53:165-70. 2007
    ....
  66. ncbi Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet
    Sofianos Andrikopoulos
    University of Melbourne, Department of Medicine, Heidelberg Repatriation Hospital, Heidelberg Heights, Victoria 3081, Australia
    J Endocrinol 187:45-53. 2005
    ..Understanding these differences will provide researchers with the information to choose the appropriate genetic background on which to express their particular genetic alteration...
  67. ncbi Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine
    Inge Sillaber
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    Psychopharmacology (Berl) 200:557-72. 2008
    ..Monoamine-based antidepressants inhibit neurotransmitter reuptake within short time. However, it commonly takes several weeks until clinical symptoms start to resolve--indicating the involvement of effects distant from reuptake inhibition...
  68. pmc Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate
    J C Bowman
    Department of Human and Animal Infectious Disease Research, Merck Research Laboratories, Rahway, New Jersey 07065-0900, USA
    Antimicrob Agents Chemother 45:3474-81. 2001
    ..fumigatus...
  69. ncbi Mapping the genetic architecture of complex traits in experimental populations
    Jian Yang
    Institute of Bioinformatics, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, PR China
    Bioinformatics 23:1527-36. 2007
    ..Two real-world phenotypes (BXD mouse olfactory bulb weight data and rice yield data) are used as exemplars to demonstrate our methods. AVAILABILITY: A software package is freely available at http://ibi.zju.edu.cn/software/qtlnetwork..
  70. pmc Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis
    J M Metselaar
    Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, The Netherlands
    Ann Rheum Dis 63:348-53. 2004
    ....
  71. ncbi Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen-induced arthritis
    Sharon Veenbergen
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3742-52. 2008
    ....
  72. ncbi Quantitative trait loci affecting ethanol sensitivity in BXD recombinant inbred mice
    K E Browman
    Portland Alcohol Research Center, Department of Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, 97201, USA
    Alcohol Clin Exp Res 24:17-23. 2000
    ..Many QTL analyses have been performed in BXD recombinant inbred (RI) strains of mice derived from a cross of C57BL/6J (B6) and DBA/2J (D2) progenitor strains...
  73. ncbi Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice
    Robnet T Kerns
    Department of Pharmacology Toxicology and the Center for Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Neurosci 25:2255-66. 2005
    ..Brain region-specific changes in signaling and neuronal plasticity may be critical components in development of lasting ethanol behavioral phenotypes such as dependence, sensitization, and craving...
  74. ncbi Gene expression differences in mice divergently selected for methamphetamine sensitivity
    Abraham A Palmer
    Columbia Genome Center, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mamm Genome 16:291-305. 2005
    ..The identified genes provide excellent candidates for future hypothesis-driven studies, translational genetic studies, and pharmacological interventions...
  75. pmc Using gene expression databases for classical trait QTL candidate gene discovery in the BXD recombinant inbred genetic reference population: mouse forebrain weight
    Lu Lu
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, PR China
    BMC Genomics 9:444. 2008
    ..We also required verification of mRNA abundance by an independent method, and finally we required either differences in protein levels or confirmed DNA sequence differences...
  76. ncbi Adrenalectomy prevents behavioural sensitisation of mice to cocaine in a genotype-dependent manner
    Inge E M de Jong
    Leiden Amsterdam Center for Drug Research and Leiden University Medical Center, Division of Medical Pharmacology, Gorlaeus Laboratories, Einsteinweg 55, P O Box 9502, 2300 RA Leiden, The Netherlands
    Behav Brain Res 177:329-39. 2007
    ..The present results demonstrate that adrenal stress hormones facilitate behavioural sensitisation to cocaine in a genotype-dependent manner and suggest that glucocorticoids contribute to strain differences in psychostimulant sensitivity...
  77. ncbi Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma
    Xiaohong Zhou
    Department of Ophthalmology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Dev Neurobiol 67:603-16. 2007
    ..These findings suggest the possible involvement of multiple biochemical events, including estrogen receptor/Akt/CREB/thioredoxin-1, and estrogen receptor/MAPK/NF-kappaB, in estrogen-mediated retinal ganglion cell protection...
  78. ncbi Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory components of the disease
    M Delgado
    Department Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain
    Nat Med 7:563-8. 2001
    ..The therapeutic effect of VIP was associated with downregulation of both inflammatory and autoimmune components of the disease. Our data indicate VIP as a viable candidate for the development of treatments for RA...
  79. pmc By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma
    Jun Song Mo
    The Howard Hughes Medical Institute, The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    J Exp Med 197:1335-44. 2003
    ..These results suggest previously unsuspected roles for bone marrow-derived cells and ocular immune privilege in the pathogenesis of PG...
  80. pmc A new set of BXD recombinant inbred lines from advanced intercross populations in mice
    Jeremy L Peirce
    Center for Neuroscience, Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, Tennessee 38163, USA
    BMC Genet 5:7. 2004
    ..elegans, and Drosophila, mouse RI panels typically consist of fewer than 30 lines. This is a severe constraint on the power and precision of mapping efforts and greatly hampers analysis of epistatic interactions...
  81. ncbi Quantitative analysis of retinal ganglion cell (RGC) loss in aging DBA/2NNia glaucomatous mice: comparison with RGC loss in aging C57/BL6 mice
    John Danias
    Department of Ophthalmology, Mount Sinai School of Medicine, Mount Sinai Medical Center, 1 Gustave L Levy Place, New York, NY 10029, USA
    Invest Ophthalmol Vis Sci 44:5151-62. 2003
    ..To quantify the extent and pattern of retinal ganglion cell (RGC) loss in the DBA2/NNia glaucomatous mouse strain as a function of age and compare it with ganglion cell loss in a nonglaucomatous strain...
  82. ncbi Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, 10314, USA
    Neuroscience 115:463-9. 2002
    ..The data also demonstrate that the differential genetic liability to morphine physical dependence begins with, and is predicted by, the first morphine exposure...
  83. ncbi Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis
    Y Tada
    Amgen Institute, Ontario Cancer Institute, Ontario, Canada
    J Immunol 156:4520-6. 1996
    ....
  84. ncbi IL-6 inhibits the tolerogenic function of CD8 alpha+ dendritic cells expressing indoleamine 2,3-dioxygenase
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, I 06122 Perugia, Italy
    J Immunol 167:708-14. 2001
    ..The activity of IL-6 includes down-regulation of IFN-gammaR expression in the CD8(+) DC subset and correlates to a reduced ability of these cells to metabolize tryptophan and initiate T cell apoptosis in vitro...
  85. ncbi What do comparative studies of inbred mice add to current investigations on the neural basis of spatial behaviors?
    C Rossi-Arnaud
    Dipartimento di Psicologia, Rome, Italy
    Exp Brain Res 123:36-44. 1998
    ..The data highlight the variability in the neural mechanisms subserving well-differentiated levels of spatial performance. The contribution of inbred mice to our general understanding of the neural basis of spatial cognition is discussed...
  86. ncbi Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis
    Deborah A Young
    Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Rheum 56:1152-63. 2007
    ..In this study, the effects of blocking IL-21 were examined in 2 rodent models of rheumatoid arthritis (RA) to determine whether IL-21 contributes to their pathologic processes...
  87. ncbi Dopamine D2 receptor binding, Drd2 expression and the number of dopamine neurons in the BXD recombinant inbred series: genetic relationships to alcohol and other drug associated phenotypes
    Robert Hitzemann
    Department of Psychiatry, SUNY at Stony Brook, NY 11794 8101, USA
    Alcohol Clin Exp Res 27:1-11. 2003
    ....
  88. ncbi Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice
    F O Risinger
    Department of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health Sciences University, 97201 3098, USA
    Alcohol Clin Exp Res 22:1234-44. 1998
    ..Some of these genes appear to influence taste sensitivity, whereas others appear to mediate sensitivity to aversive pharmacological effects of ethanol...
  89. ncbi Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains
    J K Belknap
    Research Service 151W, VA Med Ctr, Portland, OR 97201, USA
    Life Sci 57:PL117-24. 1995
    ....
  90. ncbi Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies
    A M Malfait
    Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, UK
    Arthritis Rheum 44:1215-24. 2001
    ..CONCLUSION: Chronic relapsing homologous collagen-induced arthritis is a valuable model for identifying remission-inducing antiarthritic drugs and has predictive value with respect to their joint-protective potency...
  91. ncbi M-1/M-2 macrophages and the Th1/Th2 paradigm
    C D Mills
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    J Immunol 164:6166-73. 2000
    ..Together, the results indicate that M-1- or M-2-dominant macrophage responses can influence whether Th1/Th2 or other types of inflammatory responses occur...
  92. ncbi Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma
    Michael R Steele
    Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah 84132, USA
    Invest Ophthalmol Vis Sci 47:977-85. 2006
    ..The study was undertaken to correlate changes in retinal gene expression with IOP elevation by performing microarray analysis of retinal RNA from DBA/2J mice at 3 months before disease onset and at 8 months after IOP elevation...
  93. ncbi Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB
    Kutty Selva Nandakumar
    Medical Inflammation Research, Biomedical Center, Lund University, Lund, Sweden
    Eur J Immunol 33:2269-77. 2003
    ..These results demonstrate that single IgG anti-CII mAb can induce erosive arthritis and that IgG anti-CII Ab mediate arthritis by engagement of FcgammaR...
  94. ncbi Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells
    Manuel A Gonzalez
    Cellerix SA, Tres Cantos, and FundaciĆ³n Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, Madrid, Spain
    Arthritis Rheum 60:1006-19. 2009
    ..The purpose of this study was to examine a new therapeutic strategy for RA based on the administration of human adipose-derived MSCs (AD-MSCs)...
  95. ncbi Gene-expression profile of collagen-induced arthritis
    Saleh Mohamed Ibrahim
    Institute of Immunology, University of Rostock, Schillingallee 70, Rostock, 18055, Germany
    J Autoimmun 18:159-67. 2002
    ..The profile of gene expression supports current theoretical models of disease progression and might open new perspectives for both diagnosis and treatment of arthritis...
  96. ncbi Localized expression of an anti-TNF single-chain antibody prevents development of collagen-induced arthritis
    R Smith
    Baxter Laboratory for Genetic Pharmacology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94304, USA
    Gene Ther 10:1248-57. 2003
    ..This is encouraging for the potential development of safe adoptive cellular therapies to treat autoimmunity...
  97. ncbi Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18
    X Q Wei
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, G11 6NT, United Kingdom
    J Immunol 166:517-21. 2001
    ..These data directly demonstrate a pivotal role of IL-18 in the development of inflammatory arthritis and suggest that antagonists to IL-18 may have therapeutic potential in rheumatic diseases...
  98. ncbi Differential change in neuroactive steroid sensitivity during ethanol withdrawal
    D A Finn
    Portland Alcohol Research Center, Research Service, Veterans Affairs Medical Center and Department of Behavioral Neuroscience, Oregon Health Sciences University, Portland, OR 97201, USA
    J Pharmacol Exp Ther 292:394-405. 2000
    ..These results suggest that sensitization to the anticonvulsant effect of 3alpha,5alpha-P during EtOH withdrawal does not generalize across all genotypes nor does it generalize to all of the pharmacological effects of 3alpha,5alpha-P...
  99. ncbi Variation in mouse basolateral amygdala volume is associated with differences in stress reactivity and fear learning
    Rebecca J Yang
    Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852 9411, USA
    Neuropsychopharmacology 33:2595-604. 2008
    ....
  100. ncbi Role of cyclooxygenase-2, but not cyclooxygenase-1, on type II collagen-induced arthritis in DBA/1J mice
    Takehiro Ochi
    Department of Immunology and Inflammation, Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co, Ltd, 1 6, Kashima 2 chome, Yodogawa ku, Osaka 532 8514, Japan
    Biochem Pharmacol 66:1055-60. 2003
    ..20 and 0.12 mg/kg, respectively, similar to indomethacin. In contrast, FR122047 and SC-560 had no effect. These results suggest that COX-2, but not COX-1, contributes to the edema and the formation of PGE(2) and TXB(2) in mouse CIA model...
  101. ncbi Changes in retinal neuronal populations in the DBA/2J mouse
    Jung Il Moon
    Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Seoul, 137 701, Korea
    Cell Tissue Res 320:51-9. 2005
    ..Thus, the D2 mouse retina represents a useful model for studying the pathogenesis of glaucoma and mechanisms of retinal neuronal death and for evaluating neuroprotection strategies...

Research Grants69

  1. Estrogenic Regulation of Inflammation Related to TMJD
    Phillip Kramer; Fiscal Year: 2006
    ..The function of estrogen receptors ER alpha and/or ER beta will be directly addressed pharmacologically (e.g., antiestrogen) and through mutation studies of the Fc gamma RIIIA promoter. ..
  2. DNA Methylation in Ethanol Drinking Behavior
    David P Gavin; Fiscal Year: 2013
    ..Ultimately, these studies will identify novel molecular targets in the actions of ethanol and ethanol drinking behavior, and promote the development of pharmacotherapy for alcoholism. ..
  3. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..We will test this agent in a clinically-relevant small animal model and determine the most effective dose, in anticipation of definitive large animal studies to confirm its efficacy and safety. ..
  4. Role of Central 5-HT Transmission in Respiratory Arrest Induced by Seizures
    Huajun Feng; Fiscal Year: 2013
    ..Successful implementation of the proposed studies will not only shed important light on the mechanisms of SUDEP but also provide useful information on treatments for this devastating epileptic event. ..
  5. THYROID HORMONE, EPILEPSY, AND CNS MATURATION
    SIENYAO CHOW; Fiscal Year: 1992
    ..Since hypothyroidism in infants produce cretinism, understanding the processes by which this occurs is of great importance in the clinical control of this disease...
  6. GANGLIOSIDE STUDIES
    THOMAS SEYFRIED; Fiscal Year: 1992
    ....
  7. Oral Interferon Treatment in collagen induced arthritis
    Patricia Nelson; Fiscal Year: 2003
    ..The results of these experiments should establish the therapeutic activity of IFN/tau in CIA and provide the basis for evaluating it clinically in RA. ..
  8. Genes affecting aging stem cell populations
    Gary Van Zant; Fiscal Year: 2006
    ..Thus, to aid in the future study of this locus, we propose developing a surrogate measure of the aging phenotype in young mice by using a transplantation assay. ..
  9. Mechanisms of Appetitive and Aversive Context Learning
    KENNON LATTAL; Fiscal Year: 2005
    ..These experiments will lay the groundwork for a research program that is focused on asking questions about the nature of specific contextual associations in learning and memory. ..
  10. Pharmacogenomics of ethanol and myelin gene expression
    Robnet Kerns; Fiscal Year: 2005
    ..These studies into myelin regulation by ethanol may give novel insight into signaling events evoked by acute ethanol and the mechanism(s) of certain of alcohol-associated neurological disorders. ..
  11. MODULATION OF ALCOHOL REINFORCEMENT
    Christopher Cunningham; Fiscal Year: 2007
    ..These studies could prove to be especially useful in the evaluation of putative pharmacotherapies intended to reduce alcohol craving and in the design of behavioral interventions to decrease ethanol-seeking behavior. ..
  12. Modulation of age-related changes in the auditory system
    JAMES WILLOTT; Fiscal Year: 2008
    ..The ultimate goal is to develop new approaches for amelioration and treatment ofpresbycusis and other hearing disorders. [unreadable] [unreadable]..
  13. SCREENING MICE FOR AUDITORY & NEUROBEHAVIORAL PHENOTYPES
    JAMES WILLOTT; Fiscal Year: 2002
    ..Johnson. This will be accompanied by development of an easy-to-use software/ hardware package that will integrate all screening techniques in a single, serial protocol for use on individual mice. ..
  14. PHARMACOGENOMIC STUDY OF ANTICONVULSANT THERAPY
    THOMAS FERRARO; Fiscal Year: 2003
    ....
  15. ALCOHOL EXPOSURE EFFECTS: GENETIC BASIC
    David Blizard; Fiscal Year: 2006
    ..Overall, these studies will establish a mouse model for the study of genetic factors and sex as they influence individual differences in response to ethanol exposure during adolescence and early adult life. ..
  16. Innate immunity and experimental Lyme arthritis
    Charles Brown; Fiscal Year: 2007
    ..As such these studies; may have important implications not only for Lyme disease, but for other inflammatory diseases as well. ..
  17. ELEMENTARY SCHOOL NEUROSCIENCE LITERACY
    Gary Duncan; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  18. Excessive Alcohol Intake Induced By Withdrawal
    Deborah Finn; Fiscal Year: 2005
    ..Not only will this information help in furthering our understanding of the interaction between ethanol intake and withdrawal, but it also would aid in the development of new strategies for the treatment of alcoholism. ..
  19. 2006 Genes & Behavior Conference
    Robert Hitzemann; Fiscal Year: 2006
    ..We believe the second conference will be even more successful than the first. [unreadable] [unreadable] [unreadable]..
  20. Antipsychotic Actions in Models of NMDA Hypofunction
    Gary Duncan; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  21. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  22. Autosomal Mutagenesis and Polycystic Kidney Disease
    MITCHELL TURKER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. [unreadable] [unreadable] [unreadable]..
  24. Gene silencing in mammalian cells induced by environmental exposure
    MITCHELL TURKER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  25. Dissection of Muscle Weight QTL Via Congenic Strains
    Arimantas Lionikas; Fiscal Year: 2008
    ..3) Using a bioinformatics approach, search for candidate genes within the region of Chr 9 defined by congenic strain analysis with the potential to influence muscle weight. [unreadable] [unreadable] [unreadable]..
  26. Eicosanoid regulation of experimental Lyme arthritis
    Charles R Brown; Fiscal Year: 2010
    ..This information will further our understanding of how inflammation is regulated and allow the design of more effective anti-inflammatory treatments. ..
  27. IBANGS Annual Meeting support
    John Crabbe; Fiscal Year: 2005
    ..This young society represents an opportunity to attract a core group of young investigators to alcohol research during their formative years. ..
  28. Gene Silencing in Cancer--A Model System
    MITCHELL TURKER; Fiscal Year: 2003
    ..The demonstration of each step of a multistep silencing pathway, which is currently undefined, will provide novel insight into this aberrant process in malignant cells. ..
  29. SPECTRUM OF MUTATION INDUCED BY IONIZING RADIATION
    MITCHELL TURKER; Fiscal Year: 2002
    ....
  30. Alcohol selected mice: Comparative withdrawal syndromes
    John Belknap; Fiscal Year: 2008
    ..We will use the newly available Affymetrix mouse 430 2.0 Genechip(r) representing the vast majority of all genes in the mouse genome. [unreadable] [unreadable]..
  31. GENE MAPPING FOR SENSITIVITY TO COCAINE AND AMPHETAMINE
    John Belknap; Fiscal Year: 2001
    ..The proposed studies build on 5 years of previous work and represent progress toward the identification of specific genes underlying susceptibility to aspects of psychostimulant toxicity and activation/sensitization. ..
  32. 5-HT2A RECEPTOR IN DEPRESSION: MOLECULAR MECHANISMS
    STEVEN GARLOW; Fiscal Year: 2003
    ..As the factors are characterized in the in vitro systems, their relevance to the regulation of the S-HT2A receptor in the brain will be tested in experimental animals. ..
  33. Aging and the Microvasculature
    May Reed; Fiscal Year: 2006
    ..The results will define the key points of deficient microvascular growth in the aged and also develop the microvessel sprout model into a highly useful tool for studies of vascular growth in general. ..
  34. Genetic Dissection of a Motor Central Pattern Generator
    JOHN BOUGHTER; Fiscal Year: 2008
    ..plastic behaviors will be a source of information relevant for a number of human CMS disorders involving abnormal repetitive movements. ..
  35. Ethanol Discrimination in Transgenic Mice
    KEITH SHELTON; Fiscal Year: 2002
    ..background to the ethanol's discriminative ctimnlnc effects. ..
  36. Proteomic Analysis of the Retina
    MONICA JABLONSKI; Fiscal Year: 2007
    ..These studies will also generate the framework for future project periods in which the precise molecular mechanisms and detailed pathways that control photoreceptor outer segment assembly will be determined. [unreadable] [unreadable]..
  37. Genetic analysis of Htr2c RNA editing in amygdala
    DAVID AIREY; Fiscal Year: 2008
    ..The brain region of investigation is the amygdala, which is rich in serotonin 2C receptors and plays important roles in anxiety disorders and depression. [unreadable] [unreadable]..
  38. Epigenetic control of hematopoietic stem cells
    Christa Muller Sieburg; Fiscal Year: 2007
    ..Relevance: Data from the proposed studies may provide better ways to treat leukopenia and may help in the design of approaches to selectively eradicate leukemic stem cells. ..
  39. C REACTIVE PROTEIN IN HOST DEFENSE
    ALEXANDER SZALAI; Fiscal Year: 2002
    ..These studies will increase the understanding of innate host defense mechanisms and their interaction with acquired immunity. ..
  40. INTEGRATIVE NEUROBIOLOGY OF ALCOHOL WITHDRAWAL SEIZURES
    Carl Faingold; Fiscal Year: 2002
    ..We expect these approaches to yield novel insights into the neurobiological mechanisms controlling seizure susceptibility during ethanol withdrawal and suggest improved approaches to the therapy of alcoholism. ..
  41. Gene expression networks for metabolic syndrome traits in mice
    Thomas A Drake; Fiscal Year: 2010
    ....
  42. AGING AND ENDOTHELIAL CELL FUNCTION
    May Reed; Fiscal Year: 2009
    ..The elucidation of mechanisms that regulate MMP activity in aged cells and tissues will assist the development of therapies to improve wound repair and revascularization of ischemic organs. ..
  43. ABCA1, ApoAI, and Lipid Efflux
    Jonathan Smith; Fiscal Year: 2008
    ..In addition, this study will include the identification of the apoAl oxidative modification by the enzyme myeloperoxidase that diminishes its lipid acceptor activity. ..
  44. IMMUNOLOGICAL CONSEQUENCES OF TRANSFUSION
    Loren Fast; Fiscal Year: 2002
    ..abstract_text> ..
  45. ADOLESCENT MARIJUANA USE IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2008
    ..abstract_text> ..
  46. Neurobehavioral Consequences of Adolescent Alcohol
    Cindy Ehlers; Fiscal Year: 2008
    ..AIM 3: To investigate the neurochemical substrates underlying the lasting neurobehavioral consequences of adolescent ethanol exposure, with a focus on NMDA systems ..
  47. DIETARY & GENETIC CONTROL OF ROS DAMAGE TO THE LENS
    Norman S Wolf; Fiscal Year: 2010
    ..These will aid in the search for initiating events and the mechanisms leading up to the cataract formation. ..
  48. LIFE AND DEATH OF RETINAL GANGLION CELLS
    Vittorio Porciatti; Fiscal Year: 2007
    ..Such outcomes are significant, since exploiting an animal model for testing neuroprotective strategies that preserve visual function is an important component of future research on treatments for glaucoma. ..
  49. Innate Immunity to Salmonella Infections
    Joshua Fierer; Fiscal Year: 2005
    ..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..
  50. 37th Annual Meeting of the Society for Leukocyte Biology
    Joshua Fierer; Fiscal Year: 2004
    ..We encourage students and other trainees to submit abstracts; the SLB gives awards for the best abstracts submitted by students. One of the main purposes of the meeting is to encourage young scientists. ..
  51. The Lateral Septum, Urocortin and Alcohol
    ADAM WEITEMIER; Fiscal Year: 2004
    ..Findings of this proposal will provide an important contribution to work highlighting the importance of stress- and anxiety-modulating neuropeptide systems in the regulation of alcohol-related behaviors. ..
  52. Preservation of ejaculated mouse spermatozoa
    MONIKA WARD; Fiscal Year: 2006
    ..Our expectations are that the results of this application will allow us to recommend ICSI with preserved ejaculated spermatozoa as a simple and efficient method for preservation of valuable mouse genomes. ..
  53. CD80 binding peptides as therapeutic agents in arthritis
    Mythily Srinivasan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. Molecular Mechanisms of Aging: 33rd Ann. Mtg. of AGE
    Norman Wolf; Fiscal Year: 2004
    ..Dr. Bickford has investigated hotel accommodations there and has found that both the Radisson and the Hilton offer excellent accommodations for the meeting. She is negotiating with both. ..
  55. Body Plan Formation in Early Mouse Embryo
    Yusuke Marikawa; Fiscal Year: 2004
    ....
  56. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    STEVEN GARLOW; Fiscal Year: 2004
    ..The circulating concentration of three hormones, cortisol, interleukin-1 and interleukin-6 will be measured before and after treatment, and correlated to platelet reactivity. ..
  57. RISK FACTORS FOR ALCOHOLISM IN NATIVE AMERICANS
    Cindy Ehlers; Fiscal Year: 2006
    ..The identification of such variables may potentially be useful in the development of specific prevention and treatment programs for this population as well as other Native American tribes. ..
  58. Alcoholism risk and protective factors in Trinidad
    Cindy Ehlers; Fiscal Year: 2006
    ..Study findings can be compared to similar studies being conducted in the US. We believe these studies will allow for the identification of risk and protective factors for alcoholism in these islands. [unreadable] [unreadable]..
  59. Serotonergic regulation of sensorimotor gating in mice
    DAVID AIREY; Fiscal Year: 2003
    ..Variation in the distribution of functional receptors in the brain will be tested as a neural phenotype mediating genetic and behavioral differences. ..
  60. Sperm DNA damage in fertilization
    MONIKA WARD; Fiscal Year: 2006
    ....
  61. Dopamine involvement in the rewarding properties of ethanol
    CHRISTINA GREMEL; Fiscal Year: 2006
    ..Specifically, the role of and modulation of dopamine in the nucleus accumbens and prefrontal cortex on the expression of ethanol place preference will be examined. ..
  62. Bitter Taste: Physiology and Behavior
    JOHN BOUGHTER; Fiscal Year: 2004
    ..By examining these strain differences in receptor cell function, these studies should help to link ongoing molecular advances to the neural mechanisms underlying bitter taste function. ..
  63. Algorithm for drug discovery
    GREGORY ELMER; Fiscal Year: 2007
    ..Second, it will establish a core database for data mining and provide a template for use in screening novel compounds with potential clinical efficacy. [unreadable] [unreadable] [unreadable]..
  64. Microarray analysis of morphine's behavioral effects
    GREGORY ELMER; Fiscal Year: 2007
    ..abstract_text> ..
  65. Estrogenic LXR Alpha Response /Cholesterol Homeostasis
    Phillip Kramer; Fiscal Year: 2003
    ..abstract_text> ..
  66. Augmenting innate and vaccine immune response with der-G
    Daniel Zimmerman; Fiscal Year: 2003
    ..In these studies we will follow survival and ovarian viral titers after intranasal challenge with VV. The studies will also analyze the mechanism of action to identify immune surrogates for use in clinical studies. ..
  67. Behavioral Model of Contextual Attention in the Monkey
    J Jentsch; Fiscal Year: 2003
    ..The development of such an approach to modeling contextual aspects of attention, in particular, in animals should be a major advance linking pre-clinical psychopharmacological studies and treatment-based research for schizophrenia. ..
  68. COENZYME Q INTAKE, OXIDATIVE STRESS, AND AGING IN MICE
    RAJINDAR SOHAL; Fiscal Year: 2004
    ..Results of this study will provide an understanding of the mechanisms by which CoQ intake may have a beneficial or deleterious effect on the aging process in mice. ..