inbred cba mice

Summary

Top Publications

  1. ncbi Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth
    Annie Varrault
    Institut de Genomique Fonctionnelle, CNRS UMR5203, INSERM U661, Universite Montpellier 1, Universite Montpellier 2, Montpellier, F 34094, France
    Dev Cell 11:711-22. 2006
  2. ncbi Defective B cell development and function in Btk-deficient mice
    W N Khan
    Howard Hughes Medical Institute, Childrens Hospital, Boston, Massachusetts 02115, USA
    Immunity 3:283-99. 1995
  3. pmc Repeat sequences in block 2 of Plasmodium falciparum merozoite surface protein 1 are targets of antibodies associated with protection from malaria
    Spencer D Polley
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Infect Immun 71:1833-42. 2003
  4. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
  5. pmc The Salmonella enterica serotype Typhimurium lpf, bcf, stb, stc, std, and sth fimbrial operons are required for intestinal persistence in mice
    Eric H Weening
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave, Davis, CA 95616 8645, USA
    Infect Immun 73:3358-66. 2005
  6. pmc Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus
    Fatih M Uckun
    Parker Hughes Center for Clinical Immunology, St Paul, MN 55113, USA
    BMC Infect Dis 4:1. 2004
  7. pmc Regulation of mouse follicle development by follicle-stimulating hormone in a three-dimensional in vitro culture system is dependent on follicle stage and dose
    Pamela K Kreeger
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Biol Reprod 73:942-50. 2005
  8. ncbi TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
    J J Peschon
    Department of Molecular Immunology, Immunex Corp, Seattle, WA 98101, USA
    J Immunol 160:943-52. 1998
  9. ncbi Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice
    Jess Nithianantharajah
    Howard Florey Institute, University of Melbourne, Victoria, Australia
    Neurobiol Dis 29:490-504. 2008
  10. ncbi Contralateral suppression of distortion-product otoacoustic emissions declines with age: a comparison of findings in CBA mice with human listeners
    Michael Jacobson
    Division of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
    Laryngoscope 113:1707-13. 2003

Detail Information

Publications334 found, 100 shown here

  1. ncbi Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth
    Annie Varrault
    Institut de Genomique Fonctionnelle, CNRS UMR5203, INSERM U661, Universite Montpellier 1, Universite Montpellier 2, Montpellier, F 34094, France
    Dev Cell 11:711-22. 2006
    ..Accordingly, these data identify a network of imprinted genes, including Zac1, which controls embryonic growth and which may be the basis for the implementation of a common mechanism of gene regulation during mammalian evolution...
  2. ncbi Defective B cell development and function in Btk-deficient mice
    W N Khan
    Howard Hughes Medical Institute, Childrens Hospital, Boston, Massachusetts 02115, USA
    Immunity 3:283-99. 1995
    ..These results prove that lack of Btk function results in an Xid phenotype and further suggest a differential requirement for Btk during the early stages of murine versus human B lymphocyte development...
  3. pmc Repeat sequences in block 2 of Plasmodium falciparum merozoite surface protein 1 are targets of antibodies associated with protection from malaria
    Spencer D Polley
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Infect Immun 71:1833-42. 2003
    ..The results are important for design of a vaccine to induce protective antibodies, and they address hypotheses about repeat sequences in malaria antigens...
  4. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
    ..e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies...
  5. pmc The Salmonella enterica serotype Typhimurium lpf, bcf, stb, stc, std, and sth fimbrial operons are required for intestinal persistence in mice
    Eric H Weening
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave, Davis, CA 95616 8645, USA
    Infect Immun 73:3358-66. 2005
    ..Collectively, these data show that six fimbrial operons (lpf, bcf, stb, stc, std, and sth) contribute to long-term intestinal carriage of S. enterica serotype Typhimurium in genetically resistant mice...
  6. pmc Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus
    Fatih M Uckun
    Parker Hughes Center for Clinical Immunology, St Paul, MN 55113, USA
    BMC Infect Dis 4:1. 2004
    ....
  7. pmc Regulation of mouse follicle development by follicle-stimulating hormone in a three-dimensional in vitro culture system is dependent on follicle stage and dose
    Pamela K Kreeger
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Biol Reprod 73:942-50. 2005
    ..The culture system can be adapted to each stage of development, which will be especially critical for translation to human follicles that have a longer developmental period...
  8. ncbi TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
    J J Peschon
    Department of Molecular Immunology, Immunex Corp, Seattle, WA 98101, USA
    J Immunol 160:943-52. 1998
    ..In summary, these data help clarify the biologic roles of p55 and p75 in mediating and modulating the biologic activity of TNF and provide genetic evidence for an antagonistic role of p75 in vivo...
  9. ncbi Gene-environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington's disease transgenic mice
    Jess Nithianantharajah
    Howard Florey Institute, University of Melbourne, Victoria, Australia
    Neurobiol Dis 29:490-504. 2008
    ..Our results show that cognitive deficits in HD mice can be ameliorated by environmental enrichment and suggest that changes in synaptic composition may contribute to the cognitive alterations observed...
  10. ncbi Contralateral suppression of distortion-product otoacoustic emissions declines with age: a comparison of findings in CBA mice with human listeners
    Michael Jacobson
    Division of Otolaryngology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
    Laryngoscope 113:1707-13. 2003
    ..By studying contralateral suppression on cochlear output in subjects of different ages, it is possible to describe aging effects on the medial olivocochlear system...
  11. ncbi Both CD4(+)CD25(+) and CD4(+)CD25(-) regulatory cells mediate dominant transplantation tolerance
    Luis Graca
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    J Immunol 168:5558-65. 2002
    ..Further characterization of the differentially expressed genes may lead to the development of diagnostic tests to monitor the tolerant state...
  12. ncbi Inducible gene targeting in mice
    R Kuhn
    Institute for Genetics, University of Cologne, Germany
    Science 269:1427-9. 1995
    ..Deletion was complete in liver and nearly complete in lymphocytes within a few days, whereas partial deletion was obtained in other tissues. This method can be used for the inducible inactivation of any other gene in vivo...
  13. ncbi Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes
    G A Hollander
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115
    Nature 373:350-3. 1995
    ..In addition, a normal thymic architecture is necessary for sustained T-cell ontogeny...
  14. ncbi Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes
    S Khosla
    Laboratory of Developmental Genetics and Imprinting and Laboratory of Computational Neuroscience, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
    Biol Reprod 64:918-26. 2001
    ..No alterations were detected for the imprinted gene MEST: Preimplantation culture in the presence of serum can influence the regulation of multiple growth-related imprinted genes, thus leading to aberrant fetal growth and development...
  15. ncbi 'Form variation' of the O12 antigen is critical for persistence of Salmonella Typhimurium in the murine intestine
    Lydia M Bogomolnaya
    Department of Microbial and Molecular Pathogenesis, College of Medicine, Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Mol Microbiol 70:1105-19. 2008
    ..Our data suggest that the 12-2 antigen is a S. enterica subspecies I-specific LPS modification that enhances long-term intestinal colonization, and is in contrast to the role of O-antigen variation described for Shigella...
  16. ncbi Dynamic reprogramming of DNA methylation in the early mouse embryo
    Fatima Santos
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, CB2 4AT, United Kingdom
    Dev Biol 241:172-82. 2002
    ..The three phases of methylation reprogramming may have roles in imprinting, the control of gene expression, and the establishment of nuclear totipotency...
  17. ncbi In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
    S Fagarasan
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan
    Nature 413:639-43. 2001
    ..We conclude that IgA+ cells in the gut lamina propria are generated in situ from B220+IgM+ lymphocytes...
  18. ncbi Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
    D J Rawlings
    Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024
    Science 261:358-61. 1993
    ..A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions...
  19. ncbi Real-time quantitative PCR for analysis of genetically mixed infections of malaria parasites: technique validation and applications
    Sandra J Cheesman
    Division of Biological Sciences, Institute of Cell, Animal and Population Biology, Ashworth Laboratories, University of Edinburgh, The King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 131:83-91. 2003
    ....
  20. ncbi Oxidized LDL can induce macrophage survival, DNA synthesis, and enhanced proliferative response to CSF-1 and GM-CSF
    J A Hamilton
    Inflammation Research Centre, University of Melbourne, The Royal Melbourne Hospital, Parkville, Australia
    Arterioscler Thromb Vasc Biol 19:98-105. 1999
    ....
  21. ncbi Improved cortical entrainment to infant communication calls in mothers compared with virgin mice
    Robert C Liu
    W M Keck Center for Integrative Neuroscience, University of California at San Francisco, 513 Parnassus Avenue, USA
    Eur J Neurosci 23:3087-97. 2006
    ..In the broader context, our data suggest that auditory cortical responses to communication sounds are plastic, and that communicative significance is correlated with an improved cortical representation...
  22. ncbi Macrophage effector functions controlled by Bruton's tyrosine kinase are more crucial than the cytokine balance of T cell responses for microfilarial clearance
    Sangita Mukhopadhyay
    National Institute of Immunology, New Delhi, India
    J Immunol 168:2914-21. 2002
    ..Thus, Btk is involved in inducing many macrophage effector functions, and delayed mf clearance seen in Btk-deficient xid mice is due to poor NO induction in macrophages, resulting in compromised microfilarial toxicity...
  23. ncbi CD40 ligand blockade induces CD4+ T cell tolerance and linked suppression
    K Honey
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Immunol 163:4805-10. 1999
    ..Our results suggest that, although anti-CD40L Abs are attractive clinical immunotherapeutic agents, additional therapies to control aggressive CD8+ T cell responses may be required...
  24. ncbi In vivo molecular analysis of lymphokines involved in the murine immune response during Schistosoma mansoni infection. II. Quantification of IL-4 mRNA, IFN-gamma mRNA, and IL-2 mRNA levels in the granulomatous livers, mesenteric lymph nodes, and spleens d
    G S Henderson
    Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37212
    J Immunol 148:2261-9. 1992
    ..Hence, this study shows no evidence for increased Th1 cell activity during chronic infection and suggests that modulation may be effected by a generalized suppression of lymphokine synthesis...
  25. ncbi In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance
    Dela Golshayan
    Department of Immunology, Imperial College, Hammersmith Hospital, London, UK
    Blood 109:827-35. 2007
    ..Taken together, these data suggest that in vitro-generated tailored Treg cells could be considered a therapeutic tool to promote donor-specific transplant tolerance...
  26. ncbi Particulate adjuvants can induce macrophage survival, DNA synthesis, and a synergistic proliferative response to GM-CSF and CSF-1
    J A Hamilton
    Inflammation Research Centre, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria, Australia
    J Leukoc Biol 67:226-32. 2000
    ....
  27. pmc Functional analysis of an arthritogenic synovial fibroblast
    Vassilis Aidinis
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Athens, Greece
    Arthritis Res Ther 5:R140-57. 2003
    ..Our findings support an aggressive role for the SF in the development of the disease and reinforce the perspective of a transformed-like character of the SF...
  28. ncbi Systemic administration of Congo red does not improve motor or cognitive function in R6/2 mice
    Nigel I Wood
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Neurobiol Dis 25:342-53. 2007
    ..We suggest that this is due to the inability of Congo red to cross the blood-brain barrier. Since it does not improve the behavioural deterioration that is a key feature of HD, Congo red is unlikely to be useful as a therapy for HD...
  29. ncbi Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice
    M J Guimond
    Department of Biomedical Sciences, University of Guelph, Ontario, Canada
    Biol Reprod 56:169-79. 1997
    ..These studies are the first to suggest a vital role for large granulated lymphocytes in the promotion of fetal survival and pregnancy success...
  30. ncbi Numerous, robust genetic markers for Plasmodium chabaudi by the method of amplified fragment length polymorphism
    Katrina Grech
    University of Edinburgh, Division of Biological Sciences, ICAPB, Ashworth Laboratory, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 123:95-104. 2002
    ..6 x 10(-4) per base pair. This is consistent with the sequence diversity found between alleles of candidate drug resistance genes from P. c. chabaudi clones AS and AJ identified and sequenced in this laboratory...
  31. pmc Molecular and phenotypic analysis of the CS54 island of Salmonella enterica serotype typhimurium: identification of intestinal colonization and persistence determinants
    Robert A Kingsley
    Department of Medical Microbiology and Immunology, College of Medicine, Texas A and M University System Health Science Center, College Station 77843 1114, USA
    Infect Immun 71:629-40. 2003
    ..These data suggest that colonization of the murine cecum is required for efficient fecal shedding in mice...
  32. ncbi Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development
    Serge Nef
    Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva 4, Switzerland
    Dev Biol 287:361-77. 2005
    ..These studies define the major characteristics of testicular and ovarian transcriptional programs and reveal the richness of signaling processes in differentiation of the bipotential gonads into testes and ovaries...
  33. pmc Identification of regulatory T cells in tolerated allografts
    Luis Graca
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 195:1641-6. 2002
    ..Our results suggest that T cell suppression of graft rejection is an active process that operates beyond secondary lymphoid tissue, and involves the persistent presence of regulatory T cells at the site of the tolerated transplant...
  34. ncbi Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression
    Zhenqiang Yao
    Department of Pathology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 281:11846-55. 2006
    ..Therefore, the first step of TNF-induced osteoclastogenesis is at the level of OCP genesis in the bone marrow, which represents another layer of regulation to control erosive disease...
  35. ncbi The CBA/N mouse strain: an experimental model illustrating the influence of the X-chromosome on immunity
    I Scher
    Adv Immunol 33:1-71. 1982
  36. pmc Transmission of cutaneous leishmaniasis by sand flies is enhanced by regurgitation of fPPG
    Matthew E Rogers
    Liverpool School of Tropical Medicine, University of Liverpool, Pembroke Place, Liverpool L3 5QA, UK
    Nature 430:463-7. 2004
    ..These findings emphasize that to fully understand transmission of vector-borne diseases the interaction between the parasite, its vector and the mammalian host must be considered together...
  37. pmc Linkage group selection: rapid gene discovery in malaria parasites
    Richard Culleton
    Institute of Immunity and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genome Res 15:92-7. 2005
    ..We show that molecular markers closely linked to dhfr, and only those linked to this gene, were reduced or removed by pyrimethamine treatment in accordance with the expectations of LGS...
  38. ncbi Environmental enrichment slows disease progression in R6/2 Huntington's disease mice
    Emma Hockly
    Division of Medical and Molecular Genetics, GKT School of Medicine, King s College London, UK
    Ann Neurol 51:235-42. 2002
    ..Enrichment also delayed the loss of peristriatal cerebral volume in R6/2 brains. These results could provide the basis for a rational approach to ameliorate the effects of Huntington's disease...
  39. ncbi Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants
    Stephen P Cobbold
    Sir William Dunn School of Pathology, Oxford, UK
    J Immunol 172:6003-10. 2004
    ..These data suggest that regulatory T cells maintaining transplantation tolerance after CD4 Ab blockade can be induced de novo through a TGF-beta-dependent mechanism, and come to accumulate in tolerated grafts...
  40. ncbi Spectrotemporal structure of receptive fields in areas AI and AAF of mouse auditory cortex
    Jennifer F Linden
    Keck Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
    J Neurophysiol 90:2660-75. 2003
    ....
  41. ncbi GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function
    A Bushell
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Am J Transplant 7:759-68. 2007
    ....
  42. ncbi Lactate regulates pyruvate uptake and metabolism in the preimplantation mouse embryo
    M Lane
    Institute of Reproduction and Development, Monash University, Monash Medical Centre, Clayton, Victoria 3168, Australia
    Biol Reprod 62:16-22. 2000
    ..Therefore it is proposed that the differences in pyruvate and lactate metabolism at the different stages of development are due to differences in the in situ regulation of LDH by cytosolic redox potential...
  43. ncbi Pretransplant blood transfusion without additional immunotherapy generates CD25+CD4+ regulatory T cells: a potential explanation for the blood-transfusion effect
    Andrew Bushell
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Transplantation 76:449-55. 2003
    ....
  44. ncbi Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo
    Pascale Kropf
    Department of Immunology, Faculty of Medicine, Imperial College London, UK
    FASEB J 19:1000-2. 2005
    ..To address the underlying mechanisms, the arginase-induced L-arginine catabolism was investigated and the results demonstrate that arginase regulates parasite growth directly by affecting the polyamine synthesis in macrophages...
  45. ncbi Orally administered lactoferrin restores humoral immune response in immunocompromised mice
    Jolanta Artym
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    Immunol Lett 89:9-15. 2003
    ....
  46. ncbi Mixed strain schistosome infections of snails and the evolution of parasite virulence
    C M Davies
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford
    Parasitology 124:31-8. 2002
    ..Reduced host survival was consistent with an adaptive conditional parasite response...
  47. ncbi Effect of ACE inhibitors and angiotensin II receptor antagonists in a mouse model of colorectal cancer liver metastases
    Jaclyn H Neo
    Department of Surgery, The University of Melbourne, Austin Hospital, Melbourne, Victoria, Australia
    J Gastroenterol Hepatol 22:577-84. 2007
    ..The aim of this study was to investigate the effect of an ACE-I (captopril) and an AT1R antagonist (irbesartan) in colorectal cancer liver metastases...
  48. ncbi Virulence in rodent malaria: host genotype by parasite genotype interactions
    M J Mackinnon
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, Scotland EH9 3JT, UK
    Infect Genet Evol 1:287-96. 2002
    ..Both mortality and morbidity-related factors might therefore influence the upper limit on virulence of malaria parasites...
  49. pmc Host heterogeneity is a determinant of competitive exclusion or coexistence in genetically diverse malaria infections
    Jacobus C de Roode
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Proc Biol Sci 271:1073-80. 2004
    ..Host genotype and resistance could therefore play a key role in the outcome of within-host competition between parasite clones and in the evolution of parasite virulence...
  50. pmc Is ischemia involved in the pathogenesis of murine cerebral malaria?
    L A Sanni
    Department of Pathology, University of Sydney, Sydney, Australia
    Am J Pathol 159:1105-12. 2001
    ..Mild obstructive ischemia is a likely cause of the metabolic changes during CM, but a role for immune cell effector molecules cannot be ruled out...
  51. ncbi IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
    M Hara
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Immunol 166:3789-96. 2001
    ....
  52. ncbi Organ-specific distribution of CD4+ T1/ST2+ Th2 cells in Leishmania major infection
    Pascale Kropf
    Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, GB
    Eur J Immunol 32:2450-9. 2002
    ..Since the majority of parasites persist at the local site of infection in nonhealing BALB/c mice, these results show that CD4(+) T1/ST2(+) T cells are localized at the site of active infection and inflammation in this model...
  53. ncbi Normalization of peripheral blood cell composition by lactoferrin in cyclophosphamide-treated mice
    Jolanta Artym
    Department of Experimental Therapy, Institute of Immunology and Experimental Therapy of the Polish Academy of Science, Wrocław, Poland
    Med Sci Monit 10:BR84-9. 2004
    ..The compound induces severe leuko- and neutropenia. Lactoferrin (LF) is a protein which plays a role in the innate immunity. In this study we evaluated the usefulness of LF in reversing CP-induced lympho- and neutropenia in mice...
  54. pmc Development of an intranasal vaccine to prevent urinary tract infection by Proteus mirabilis
    Xin Li
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 72:66-75. 2004
    ..Intranasal immunization of CBA mice with MBP-MrpH (residues 23 to 157) conferred effective protection against urinary tract infection by P. mirabilis (P < 0.002)...
  55. pmc Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation
    B Qiu
    Departments of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, 2215 Fuller Rd, Ann Arbor, MI 48105, USA
    Am J Pathol 158:1503-15. 2001
    ..These findings indicate that type-1 and type-2 granulomas display characteristic CK profiles with coordinated expression that is under cytokine-mediated regulation...
  56. ncbi Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice
    Ping Li
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 50:265-76. 2004
    ..To investigate the mechanisms whereby tumor necrosis factor alpha (TNFalpha) increases osteoclastogenesis in vivo...
  57. ncbi Active cell migration drives the unilateral movements of the anterior visceral endoderm
    Shankar Srinivas
    Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 131:1157-64. 2004
    ....
  58. ncbi Gene-expression profiling discriminates between cerebral malaria (CM)-susceptible mice and CM-resistant mice
    Nicolas F Delahaye
    Laboratoire de Pharmacogénétique des maladies parasitaires EA864, Universite de la Mediterranee IFR48, Marseille, France
    J Infect Dis 193:312-21. 2006
    ....
  59. ncbi Differences in circadian photosensitivity between retinally degenerate CBA/J mice (rd/rd) and normal CBA/N mice (+/+)
    T Yoshimura
    Department of Animal Physiology, School of Agriculture, Nagoya University, Japan
    J Biol Rhythms 9:51-60. 1994
    ..These results are discussed in relation to recent findings in retinally degenerate C57BL mice, which have been found to have normal circadian sensitivity to light...
  60. pmc Mixed strain infections and strain-specific protective immunity in the rodent malaria parasite Plasmodium chabaudi chabaudi in mice
    Sandra Cheesman
    School of Biological Sciences, Institute of Immunology and Infection Research, University of Edinburgh, The Kings Buildings, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Infect Immun 74:2996-3001. 2006
    ....
  61. ncbi T cell suppression in transplantation tolerance through linked recognition
    J D Davies
    Department of Biology and Cancer Center, University of California San Diego, La Jolla, 92093 0063, USA
    J Immunol 156:3602-7. 1996
    ..In addition, our preliminary findings suggest that suppression via linked recognition can also lead to tolerance to the third party Ag...
  62. ncbi Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities
    A Schedl
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
    Cell 86:71-82. 1996
    ..Thus, at least five different eye phenotypes are associated with changes in PAX6 expression. We provide evidence that not only reduced, but also increased levels of transcriptional regulators can cause developmental defects...
  63. pmc Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3
    Vassiliki Fotaki
    Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:9282-92. 2006
    ..We propose that Gli3 is indispensable for formation of an intact telencephalic-diencephalic boundary and for preventing the abnormal positioning of diencephalic cells in the dorsal telencephalon...
  64. ncbi Botulinum toxin B-induced mouse model of keratoconjunctivitis sicca
    Olan Suwan-apichon
    Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland 21286, USA
    Invest Ophthalmol Vis Sci 47:133-9. 2006
    ..To develop a mouse model of human chronic dry eye (keratoconjunctivitis sicca [KCS])...
  65. ncbi Animal model of drug-resistant tumor progression
    Nadezda Mironova
    Institute of Chemical Biology and Fundamental Medicine, Siberian Branch Russian Academy of Sciences, 8 Lavrentiev Avenue, 630090 Novosibirsk, Russian Federation
    Ann N Y Acad Sci 1091:490-500. 2006
    ....
  66. ncbi Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells
    W Held
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Nature 376:355-8. 1995
    ....
  67. ncbi Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging
    Bethany M Tesar
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Aging Cell 5:473-86. 2006
    ..Therefore, our results demonstrate that myeloid DCs manifest preserved TLR-mediated immune responses with aging. However, aging critically impairs intrinsic adaptive T-cell function...
  68. ncbi Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2
    Q Zhang
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 52:2708-18. 2005
    ..To investigate why bisphosphonates are less effective at preventing focal bone loss in rheumatoid arthritis (RA) patients than in those with generalized osteoporosis, and the mechanisms involved...
  69. ncbi Enhanced proliferative potential in culture of cells from p53-deficient mice
    T Tsukada
    Laboratory of Molecular Oncology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Japan
    Oncogene 8:3313-22. 1993
    ..No effects of p53-deficiency were found in proliferation of cardiac muscle cells or hepatocytes...
  70. ncbi Identification of gene markers for the prediction of allograft rejection or permanent acceptance
    B Sawitzki
    Institute of Medical Immunology, Charité University Medicine Berlin Campus Mitte, Germany
    Am J Transplant 7:1091-102. 2007
    ..Interestingly, downregulation of TOAG-1 and alpha-1,2-mannosidase expression occurred in graft infiltrating cells and expression of both genes was also downregulated after T-cell activation in vitro...
  71. ncbi A central role for alpha beta T cells in the pathogenesis of murine lupus
    J P Seery
    Keratinocyte Laboratory, Lymphocyte Molecular Biology Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    J Immunol 162:7241-8. 1999
    ..Our findings emphasize the relevance of this murine lupus model to the human disease...
  72. pmc Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia
    D R Collingridge
    PET Oncology Group, Imperial College School of Medicine, Hammersmith Hospital, MRC Cyclotron Building, Du Cane Road, London, W12 0NN, UK
    Br J Cancer 84:626-30. 2001
    ..Reduced oxygenation may act as a stimulus for recruitment of immune cells to the tumour mass, and the detection of either IgG-positive host cells or macrophages may offer an alternative method for monitoring tumour hypoxia...
  73. ncbi Evidence that the testis determination pathway interacts with a non-dosage compensated, X-linked gene
    P S Burgoyne
    Laboratory of Developmental Genetics, National Institute for Medical Research, London, UK
    Int J Dev Biol 45:509-12. 2001
    ..These mice showed similar levels of testicular development to X(M)O mice with the transgene; thus the non-dosage compensated X gene maps outside the PAR...
  74. ncbi Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes
    J D Thomas
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Science 261:355-8. 1993
    ..Because this region of Btk lies outside any obvious kinase domain, the xid mutation may define another aspect of tyrosine kinase function...
  75. pmc Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice
    D A Grillot
    Department of Pathology, University of Michigan, Ann Arbor 48109 0608, USA
    J Exp Med 182:1973-83. 1995
    ..In contrast to Bcl-2, which has been implicated in the maintenance of mature T cells, Bcl-xL appears to provide a survival signal for the maintenance of more immature CD4+CD8+ thymocytes before positive selection...
  76. ncbi Identification of the Ped gene at the molecular level: the Q9 MHC class I transgene converts the Ped slow to the Ped fast phenotype
    Y Xu
    Department of Biology, Northeastern University, Boston, Massachusetts 02115
    Biol Reprod 51:695-9. 1994
    ..In addition, it was found that introduction of the Q9 gene converted the Ped gene phenotype of the recipient strain from slow to fast. Therefore, the Ped gene product is the Qa-2 antigen encoded by the Q9 gene...
  77. ncbi Resistance of C57BL/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production
    Shinjiro Hamano
    Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 177:1208-13. 2006
    ..We conclude that nonhemopoietic cells mediate the natural resistance to intestinal amoebiasis of B6 mice, yet this resistance depends on hemopoietic IL-10 activity...
  78. pmc B cell-dependent T cell responses: IgM antibodies are required to elicit contact sensitivity
    Ryohei F Tsuji
    Noda Institute for Scientific Research, Chiba ken 278, Japan
    J Exp Med 196:1277-90. 2002
    ..The IgM and challenge antigen likely form local complexes that activate complement, generating C5a, leading to local vascular activation to recruit the antigen-primed effector T cells that mediate the CS response...
  79. pmc Susceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen
    A E Lukacher
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 181:1683-92. 1995
    ..These results indicate identity between Pyvs and Mtv-7 sag, and demonstrate a novel mechanism of inherited susceptibility to virus-induced tumors based on effects of an endogenous superantigen on the host's T cell repertoire...
  80. ncbi Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance
    L Graca
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Immunol 165:4783-6. 2000
    ..Therefore, tolerance induced with anti-CD154 Abs involves not only the deletion of potentially aggressive T cells, but also a contagious spread of tolerance to new cohorts of graft-reactive T cells as they arise...
  81. pmc Uropathogenic Escherichia coli outer membrane antigens expressed during urinary tract infection
    Erin C Hagan
    Department of Microbiology and Immunology, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Infect Immun 75:3941-9. 2007
    ..coli isolates. Thus, we suggest that the conserved outer membrane antigens identified in this study could be rational candidates for a UTI vaccine designed to elicit protective immunity against UPEC infection...
  82. ncbi Reconstitution of the cellular immune response by lactoferrin in cyclophosphamide-treated mice is correlated with renewal of T cell compartment
    Jolanta Artym
    Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland
    Immunobiology 207:197-205. 2003
    ..In conclusion, we showed for the first time that lactoferrin, given orally to CP-immunosuppressed mice, could reconstitute a T-cell mediated immune response by renewal of the T cell pool...
  83. ncbi Tissue-specific microvascular endothelial cell lines from H-2K(b)-tsA58 mice for studies of angiogenesis and metastasis
    Robert R Langley
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:2971-6. 2003
    ..The immortalized endothelial cell lines established from H-2K(b)-tsA58 mice provide, for the first time, a cell culture system to examine factors regulating angiogenesis and tumor cell arrest in different organ systems...
  84. pmc Hematopoietic chimerism and central tolerance created by peripheral-tolerance induction without myeloablative conditioning
    Edward Seung
    Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Clin Invest 112:795-808. 2003
    ..We conclude that robust allogeneic hematopoietic chimerism and central tolerance can be established in the absence of host myeloablative conditioning using a peripheral transplantation tolerance protocol...
  85. ncbi Bacteriophages provide regulatory signals in mitogen-induced murine splenocyte proliferation
    Michał Zimecki
    Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences, Rudolfa Weigla 12, 53 114 Wrocław, Poland
    Cell Mol Biol Lett 8:699-711. 2003
    ..This phenomenon may explain the costimulatory activity of phages in the model described...
  86. ncbi Comparison of topical dry eye medications for the treatment of keratoconjunctivitis sicca in a botulinum toxin B-induced mouse model
    Kaevalin Lekhanont
    Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, MD, USA
    Cornea 26:84-9. 2007
    ..To compare the effects of topical dry eye medications including anti-inflammatory agents and lubricant eyedrops for the treatment of keratoconjunctivitis sicca (KCS) in a botulinum toxin B (BTX-B)-induced mouse model...
  87. ncbi Mainstream tobacco smoke causes paternal germ-line DNA mutation
    Carole L Yauk
    Mutagenesis Section, Environmental and Occupational Toxicology Division, Health Canada, Ottawa, Ontario, Canada
    Cancer Res 67:5103-6. 2007
    ..Our research suggests that the consequences of smoking extend beyond the smoker to their nonsmoking descendents...
  88. ncbi Factors influencing Leishmania major infection in IL-4-deficient BALB/c mice
    P Kropf
    Imperial College London, Faculty of Medicine, Division of Investigative Science, Department of Immunology, London, UK
    Parasite Immunol 25:439-47. 2003
    ..Thus, we conclude that differences in the age of the mice and in the arginase activity of the different isolates of parasites are factors that can influence the non-healing phenotype of IL-4-/- BALB/c mice...
  89. ncbi CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses
    Cherry I Kingsley
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Immunol 168:1080-6. 2002
    ..In clinical transplantation, the generation of regulatory T cells that could provide dynamic control of rejection responses is a possible route to permanent graft survival without the need for long-term immunosuppression...
  90. ncbi Noninvasive measurement of rodent intraocular pressure with a rebound tonometer
    Wan Heng Wang
    Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    Invest Ophthalmol Vis Sci 46:4617-21. 2005
    ..The present study evaluated the applicability of a rebound tonometer in measuring intraocular pressure (IOP) in rats and mice...
  91. pmc Transcriptome of uropathogenic Escherichia coli during urinary tract infection
    Jennifer A Snyder
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, USA
    Infect Immun 72:6373-81. 2004
    ..This study represents the first assessment of any E. coli pathotype's transcriptome in vivo and provides specific insights into the mechanisms necessary for urinary tract pathogenesis...
  92. ncbi Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice
    Xiao Han Tang
    Departments of Pharmacology and Pathology, Weill Medical College of Cornell University, New York, New York
    Clin Cancer Res 10:301-13. 2004
    ..We have developed a mouse model using the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in the drinking water to induce tumorigenesis in the mouse oral cavity...
  93. ncbi Amplified fragment length polymorphism measures proportions of malaria parasites carrying specific alleles in complex genetic mixtures
    Axel Martinelli
    University of Edinburgh, Division of Biological Sciences, ICAPB, Ashworth Laboratory, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 136:117-22. 2004
    ..The precision of the method is sufficient to detect reliably the effects of phenotypic selection at loci closely linked to a genetic locus under selection...
  94. pmc An AFLP-based genetic linkage map of Plasmodium chabaudi chabaudi
    Axel Martinelli
    Institute for Immunology and Infection Research, School of Biological Science, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Malar J 4:11. 2005
    ..Despite the availability of some genome sequence data, an extensive genetic linkage map is needed for mapping the genes involved in certain traits...
  95. ncbi Apoptin induces apoptosis in an oral cancer mouse model
    Remilio A L Schoop
    Department of Otolaryngology, Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Biol Ther 7:1368-73. 2008
    ..The fact that apoptin induces apoptosis in primary squamous cell carcinoma cells indicates that apoptin is a potential therapeutic agent for treatment of head and neck squamous cell carcinoma...
  96. ncbi A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling
    L Alexopoulou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 27:2588-92. 1997
    ..These results indicate that blocking the activities of both soluble and transmembrane TNF may be required to effectively neutralize the pathogenic potential of this cytokine in arthritis...
  97. pmc Evaluation of T cell responses in healing and nonhealing leishmaniasis reveals differences in T helper cell polarization ex vivo and in vitro
    B S Choi
    Department of Immunology, Imperial College London, UK
    Parasite Immunol 31:199-209. 2009
    ..Our results suggest that determination of both ex vivo as well as in vitro T cell responses is crucial to characterize immune responses during experimental leishmaniasis...
  98. ncbi Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria
    R Lucas
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Medical Center, Geneva, Switzerland
    Eur J Immunol 27:1719-25. 1997
    ..In conclusion, these results indicate that the interaction between membrane TNF and TNFR2 is crucial in the development of this neurological syndrome...
  99. pmc Sat, the secreted autotransporter toxin of uropathogenic Escherichia coli, is a vacuolating cytotoxin for bladder and kidney epithelial cells
    Debra M Guyer
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
    Infect Immun 70:4539-46. 2002
    ..coli CFT073, elicits defined damage to kidney epithelium during upper urinary tract infection and thus contributes to pathogenesis of urinary tract infection...
  100. ncbi Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo
    P Thomas
    Laboratory of Mammalian Development, National Institute for Medical Research, Mill Hill, London, UK
    Curr Biol 6:1487-96. 1996
    ....
  101. ncbi Early treatment during a primary malaria infection modifies the development of cross immunity
    M Legorreta-HerrEra
    Laboratorio de Immunología Molecular, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónomia de Mexico, Iztapalapa, Mexico
    Parasite Immunol 26:7-17. 2004
    ..This finding should be taken into account for the development of effective malaria vaccines...

Research Grants63

  1. Immunoregulation of Schistosomiasis
    Miguel J Stadecker; Fiscal Year: 2013
    ..Their ultimate objective is the design of focused, realistic and practical strategies for amelioration of disease, which could be amenable for consideration and implementation in the human patient population. ..
  2. Targeted Liposomal Delivery of CD147 siRNA to Murine Head and Neck Cancer Models
    Nadarajah Vigneswaran; Fiscal Year: 2010
    ..We propose to develop liposomal siRNA to block CD147, a molecule implicated in resistance to chemoradiation, and test whether it enhances the efficacy of chemotherapy in a mouse model of head and neck cancer. ..
  3. BACTERIAL UREASE IN THE CATHETERIZED URINARY TRACT
    HARRY MOBLEY; Fiscal Year: 1990
    ..Enzyme activities will be determined by potentiometric and spectrophotometric assays. Urease-negative bacterial strains will be constructed by marker exchange and tested in a CBA mouse model of urinary tract infection...
  4. Mouse Strain dependent innate resistance to intestinal amebiasis
    Eric Houpt; Fiscal Year: 2009
    ....
  5. EFFECTS OF AGING ON DELAYED HYPERSENSITIVITY IN MICE
    ALFRED CROWLE; Fiscal Year: 1980
    ....
  6. Auditory Plasticity in the Aged Mouse
    Jeremy Turner; Fiscal Year: 2005
    ..abstract_text> ..
  7. ACOUSTIC ENVIRONMENT EFFECTS ON DPOAES IN AGING MICE
    Glen Martin; Fiscal Year: 1999
    ..abstract_text> ..
  8. ROLES OF ACETYLCHOLINE IN AGE RELATED HEARING DISORDERS
    Kejian Chen; Fiscal Year: 2001
    ..Correlation of the results from this study and those from previous studies on hearing function of this mouse model may increase understanding of age-related hearing disorders and suggest new treatment directions. ..
  9. HERPES SIMPLEX VIRUS GE AND GI PROTEIN SPECIFIC T-CELLS
    Pamela Diaz; Fiscal Year: 1993
    ..These studies will help to delineate the effect that gE and gI have upon the immune system and whether their inclusion in any HSV vaccine would be beneficial or detrimental to the host...
  10. MOLECULAR BASIS OF HEARING LOSS IN AGING
    Ana Vazquez; Fiscal Year: 1999
    ..Together, these goals are aimed at confirming the relevance of these molecules to AHL. In this manner, new avenues of productive research may be opened up to the elucidation of mechanisms that cause hearing loss. ..
  11. Cartilage Fracture Toughness By Micropenetration
    Jack Lewis; Fiscal Year: 2006
    ..Histology and SEM of the mouse cartilage will be used Ito evaluate fibrillation. Data will be used to test the hypothesis that cartilage weakening precedes fibrillation in an animal model of naturally occurring OA. ..
  12. Genetic Modulation of Noise Injury to the Cochlear Lateral Wall
    KEVIN OHLEMILLER; Fiscal Year: 2007
    ..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
  13. Genetic Modulation of Noise Injury to the Cochlear Lateral Wall
    KEVIN OHLEMILLER; Fiscal Year: 2009
    ..The gene, and the processes in which it is involved, may affect the long-term stability of cochlear injury, and the accumulation of injury that may be diagnosed as presbycusis. ..
  14. COCHLEAR VULNERABILITY/REACTIVE OXYGEN SPECIES
    KEVIN OHLEMILLER; Fiscal Year: 2003
    ..Our experiments will establish how well the dynamics of ROS production predict cochlear injury, and whether progressive deafness genes may impair cochlear ROS regulation. ..
  15. Effect of Noise Induced Hearing Loss on AVCN Principal Neurons
    Yong Wang; Fiscal Year: 2008
    ..We will take advantage of the low individual variability in noise exposure outcome in inbred CBA mice. Using a modified whole cochlear nucleus slice preparation, we will probe several aspects of synaptic ..
  16. Cholinergic Modulation of Inflammatory CNS Cytokines
    LORISE GAHRING; Fiscal Year: 2006
    ..abstract_text> ..
  17. Nicotine Modulation of Caspases in Non-Neuronal Cells
    LORISE GAHRING; Fiscal Year: 2006
    ....
  18. Developmental Gene Regulation in Schistosoma mansoni
    David Williams; Fiscal Year: 2006
    ..mansoni genome and studies using DNA micro arrays. Furthermore, we will validate the use of SAGE technology to study differential global gene expression in S. mansoni. ..
  19. Role of Fungal Microflora in Mucosal Tolerance/Immunity
    GARY HUFFNAGLE; Fiscal Year: 2009
    ..These studies will provide the basic science foundation for future studies in humans for understanding how and why manipulation of the microflora (by diet or probiotics) can alter or prevent allergies. ..
  20. Mechanisms of anti-schistosome artemisinin chemotherapy
    David Williams; Fiscal Year: 2006
    ..mansoni translationally controlled tumor protein. The critical conclusions of this study will direct subsequent future experiments into the molecular mechanism of artemisinin's anti-parasitic activity. ..
  21. High Throughput Proteome Analysis of Schistosoma mansoni
    David Williams; Fiscal Year: 2005
    ..Completion of this project will provide information on significant protein complements of S. mansoni and also validate the use of MudPIT in future proteomic studies to define a comprehensive view of the S. mansoni proteomes. ..
  22. Auditory processing of signals in noise
    Bradford May; Fiscal Year: 2006
    ..A better understanding of the brain's signal processing solutions will lead to improved designs for assistive listening devices that now show poor performance in noisy environments. ..
  23. HTS Inhibitors:Schistosoma Mansoni Peroxiredoxins(RMI)
    David Williams; Fiscal Year: 2005
    ..This will be the first step in the development of novel antischistosome chemotherapies, which are essential for continued public health measures. ..
  24. Genetics of complex behaviors in the mouse.
    Valerie Bolivar; Fiscal Year: 2007
    ..It is anticipated that the successful positional cloning of this gene will lead to new information on the pathways involved in the habituation process. ..
  25. Role of Oxylipins in Cryptococcal Pathogenesis
    GARY HUFFNAGLE; Fiscal Year: 2008
    ..production; (3) to determine the role of the fungal oxylipin CnPGEx in cryptococcal biology and pathogenesis; (4) to determine the role of host PGE2 and other prostaglandins in cryptococcal biology and host immunity ..
  26. Initiation of Contact and Asthmatic Hypersensitivity
    Philip Askenase; Fiscal Year: 2008
    ..abstract_text> ..
  27. MOLECULAR AND CELLULAR BACTERIAL PATHOGENESIS
    David Briles; Fiscal Year: 2008
    ..The MCBP advisory committee will advise the trainees in their research and training programs and in their search for a job or postdoctoral position at the completion of their MCBP training. [unreadable] [unreadable]..
  28. Modulation of age-related changes in the auditory system
    JAMES WILLOTT; Fiscal Year: 2008
    ..The ultimate goal is to develop new approaches for amelioration and treatment ofpresbycusis and other hearing disorders. [unreadable] [unreadable]..
  29. SPECTRAL CUES FOR SOUND LOCALIZATION
    Bradford May; Fiscal Year: 2008
    ..Consequently, this research will enhance our current understanding of the processes and perceptions that shape directional hearing, speech processing, and compensation for hearing loss in humans. [unreadable] [unreadable]..
  30. PHASE III TRIAL OF TETRATHIOMOLYBDATE IN PRIMARY BILIAR*
    George Brewer; Fiscal Year: 2007
    ..Abstract Not Provided ..
  31. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  32. Disulfide redox balance in Schistosoma mansoni
    David Williams; Fiscal Year: 2003
    ..Because disulfide redox balance in schistosomes is centered on a single, key enzyme and is fundamentally different from host mechanisms we propose that this pathway is a promising target for novel, rational drug design. ..
  33. CHEMOKINE RECEPTORS IN IMMUNITY TO C NEOFORMANS
    GARY HUFFNAGLE; Fiscal Year: 2003
    ..neoformans infection; (5) To determine the role of MCP-1 and CCR2 in the development of a Th2 response to C. neoformans. ..
  34. MOLECULAR MECHANISMS OF BONE MARROW INDUCED TOLERANCE
    James George; Fiscal Year: 2003
    ..The information generated will provide information regarding the specific cellular and subcellular events that are critical to the induction and maintenance of tolerance in this system. ..
  35. ALTERED MATRIX METALLOPROTEINASES IN HEART FAILURE
    JEANINE D ARMIENTO; Fiscal Year: 2002
    ..Finally, this proposal will investigate the role of interstitial collagenase (MMP-13) in cardiac function and development through the generation of an MMP-13 knockout mouse. ..
  36. SCREENING MICE FOR AUDITORY & NEUROBEHAVIORAL PHENOTYPES
    JAMES WILLOTT; Fiscal Year: 2002
    ..Johnson. This will be accompanied by development of an easy-to-use software/ hardware package that will integrate all screening techniques in a single, serial protocol for use on individual mice. ..
  37. Control of Physical Activity by Genetic Factors
    J Lightfoot; Fiscal Year: 2003
    ..This will be the first project investigating the genetic basis of physical activity level to use these techniques that have already proven successful in other fields (e.g. cystic fibrosis). ..
  38. ANALYSES OF COMMUNICATION SOUNDS IN AUDITORY MIDBRAIN
    CHRISTINE PORTFORS; Fiscal Year: 2005
    ..This study will establish the extent of selectivity among social vocalizations in the IC and the contribution of combination sensitivity to selectivity. ..
  39. MODULATION OF TH1/TH2 RESPONSES BY INNATE IMMUNITY
    GARY HUFFNAGLE; Fiscal Year: 2004
    ..One of the potential implications of these studies is that therapies inhibiting melanin biosynthesis or activity may also have an adjuvant effect and promote the development of protective Th1 immunity to C. neoformans. ..
  40. IMMUNOREGULATION IN SCHISTOSOMIASIS
    Miguel Stadecker; Fiscal Year: 2005
    ..The long-term goal of this project is the achievement of effective and lasting specific T cell tolerance by way of a suitable biological vector capable of delivering the peptides to the host suffering from, or susceptible to, disease. ..
  41. Genetics of spatial learning and memory
    Valerie Bolivar; Fiscal Year: 2005
    ..abstract_text> ..
  42. MOLECULAR MECHANISMS OF TRANSCRIPTIONAL REPRESSION
    Robert Schlegel; Fiscal Year: 2003
    ..abstract_text> ..
  43. Immunoregulation in the Peritoneal Cavity
    James Riggs; Fiscal Year: 2005
    ..These studies will also provide information regarding how constitutive suppression of Thl activation could facilitate the generation of B cell lymphoma from B-l B cells in the PerC. ..
  44. Regulation of Polyoma Virus-Specific CD8+ T Cells
    ARON LUKACHER; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  45. Cisplatin and Mechanisms of Long-term Male Infertility
    JOHN RICHBURG; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  46. SCF in liver repair after hepatectomy or toxic injury
    Lisa Colletti; Fiscal Year: 2006
    ..These studies will help to elucidate novel mechanisms in SCF-mediated hepatocyte protection and regeneration in a clinically relevant liver resection and toxicity model. ..
  47. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2006
    ..The results of these studies will provide rationale for novel therapeutic treatment of IBD and other inflammatory diseases. ..
  48. MUCOSAL IMMUNIZATION--PREVENTION OF SYSTEMIC CANDIDIASIS
    LUCY FREYTAG; Fiscal Year: 2003
    ..abstract_text> ..
  49. Tilting the balance in cancer immunotherapy and autoimmunity
    Wei Zen Wei; Fiscal Year: 2010
    ..Establish a vaccination regimen to inhibit spontaneous tumorigenesis and tumor metastasis, and 3. Amplify the immunogenicity of a growing tumor by in situ transfection with TetC DNA. ..
  50. PHENOLS/CATECHOLS IN OCCUPATIONAL/CONTACT VITILIGO SKIN
    Raymond Boissy; Fiscal Year: 2002
    ....
  51. Concurrent Immune Stimulation and Inhibition of Angiogenesis for Glioma Therapy
    JOHN OHLFEST; Fiscal Year: 2008
    ..The project has high impact potential because it may identify a new treatment approach for glioblastoma patients. [unreadable] [unreadable] [unreadable]..
  52. NEW TRANSGENIC MODELS OF HYPERTRIGLYCERIDEMIA
    Neil Shachter; Fiscal Year: 2001
    ..To test this, ApoCI, apoCII and apoCIII Tg mice will be crossed with the gene-targeted mice and the effects on lipoprotein metabolism will be assessed. ..
  53. 2004 National Vitiligo Foundation Scientific Conference
    Raymond Boissy; Fiscal Year: 2004
    ..In addition, mini-symposiums will be organized for each of the sessions. ..
  54. Regulation of Macrophage Cell Death by Toxoplasma gondii
    Amos Orlofsky; Fiscal Year: 2008
    ..Finally cytotoxic T lymphocytes will be exploited as a tool to distinguish parasite-regulated apoptosis from parasite-regulated death per se with respect to effects on T. gondii expansion in vivo. [unreadable] [unreadable] [unreadable]..
  55. Proteasomal regulation of TNF-mediated local bone loss
    Lianping Xing; Fiscal Year: 2007
    ..Results from this study should open up a new field of investigation into the involvement of Smurf E3 ligases in inflammation-mediated osteoblast inhibition in erosive bone diseases. [unreadable] [unreadable] [unreadable]..
  56. Development of a rapid behavioral tinnitus screen for rats.
    Jeremy Turner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. Vevo 770 High Resolution Ultrasound Imaging System
    Marielle Scherrer Crosbie; Fiscal Year: 2007
    ..We will use this machine to better understand the pathways involved in pulmonary and systemic high blood pressure, atherosclerosis, heart failure, as well as to attempt to image stem cells. [unreadable] [unreadable] [unreadable]..
  58. FN FAK SIGNALING AXIS AND TUMORIGENESIS
    Dusko Ilic; Fiscal Year: 2004
    ..abstract_text> ..
  59. Regulation of Pancreas Development by P13K/Akt Signaling
    Ernesto Bernal Mizrachi; Fiscal Year: 2006
    ..abstract_text> ..
  60. Stress Effects on an Animal Model of Autoimmune Disease
    CHRISTABEL WELSH; Fiscal Year: 2005
    ..Clarifying how environmental stressors influence an individual's vulnerability to autoimmune disease may increase our understanding of diseases such as multiple sclerosis and thus lead to the development of therapeutic regimens. ..
  61. Antiviral Therapy for Polyomavirus Infection
    ARON LUKACHER; Fiscal Year: 2008
    ..g., FDA-approved Gleevec) limit polyomavirus infection, a critical prelude for their potential therapeutic use to prevent polyomavirus reactivation in immunosuppressed individuals. [unreadable] [unreadable] [unreadable]..