inbred c3h mice

Summary

Top Publications

  1. ncbi Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
    A Poltorak
    Howard Hughes Medical Institute and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9050, USA
    Science 282:2085-8. 1998
  2. pmc MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    R Shimazu
    Department of Immunology, Saga Medical School, Saga, Japan
    J Exp Med 189:1777-82. 1999
  3. pmc Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
    Christian Termeer
    Department of Dermatology, University of Freiburg, Freiburg D 79104, Germany
    J Exp Med 195:99-111. 2002
  4. ncbi TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi
    Utpal Pal
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 119:457-68. 2004
  5. ncbi The Lyme disease agent exploits a tick protein to infect the mammalian host
    Nandhini Ramamoorthi
    Sections of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 436:573-7. 2005
  6. pmc Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
    S T Qureshi
    Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 1A4
    J Exp Med 189:615-25. 1999
  7. ncbi Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    K Hoshino
    Department of Biochemistry, Hyogo College of Medicine, Japan
    J Immunol 162:3749-52. 1999
  8. ncbi Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi
    J Seshu
    Department of Microbial and Molecular Pathogenesis, Texas A and M University Health Science Center, 407 Reynolds Medical Building, College Station, 77843, USA
    Mol Microbiol 59:1591-601. 2006
  9. ncbi Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands
    S Das
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8031, USA
    J Infect Dis 184:1056-64. 2001
  10. ncbi Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology
    Sarah C Higgins
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Immunol 171:3119-27. 2003

Detail Information

Publications280 found, 100 shown here

  1. ncbi Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
    A Poltorak
    Howard Hughes Medical Institute and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9050, USA
    Science 282:2085-8. 1998
    ..Destructive mutations of Tlr4 predispose to the development of Gram-negative sepsis, leaving most aspects of immune function intact...
  2. pmc MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    R Shimazu
    Department of Immunology, Saga Medical School, Saga, Japan
    J Exp Med 189:1777-82. 1999
    ..MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms...
  3. pmc Oligosaccharides of Hyaluronan activate dendritic cells via toll-like receptor 4
    Christian Termeer
    Department of Dermatology, University of Freiburg, Freiburg D 79104, Germany
    J Exp Med 195:99-111. 2002
    ..In conclusion, this is the first report that polysaccharide degradation products of the extracellular matrix produced during inflammation might serve as an endogenous ligand for the TLR-4 complex on DCs...
  4. ncbi TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi
    Utpal Pal
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 119:457-68. 2004
    ..Identification of an I. scapularis receptor for B. burgdorferi is the first step toward elucidating arthropod ligands that are required for survival of spirochetes in nature...
  5. ncbi The Lyme disease agent exploits a tick protein to infect the mammalian host
    Nandhini Ramamoorthi
    Sections of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 436:573-7. 2005
    ..scapularis drastically reduced the capacity of tick-borne spirochaetes to infect mice. These results show the capacity of a pathogen to use a secreted arthropod protein to help it colonize the mammalian host...
  6. pmc Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
    S T Qureshi
    Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 1A4
    J Exp Med 189:615-25. 1999
    ..Identification of distinct mutations involving the same gene at the Lps locus in two different hyporesponsive inbred mouse strains strongly supports the hypothesis that altered Tlr4 function is responsible for endotoxin tolerance...
  7. ncbi Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    K Hoshino
    Department of Biochemistry, Hyogo College of Medicine, Japan
    J Immunol 162:3749-52. 1999
    ..Overexpression of wild-type TLR4 but not the mutant TLR4 from C3H/HeJ mice activated NF-kappaB. Taken together, the present study demonstrates that TLR4 is the gene product that regulates LPS response...
  8. ncbi Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi
    J Seshu
    Department of Microbial and Molecular Pathogenesis, Texas A and M University Health Science Center, 407 Reynolds Medical Building, College Station, 77843, USA
    Mol Microbiol 59:1591-601. 2006
    ..burgdorferi-specific pathogenic mechanisms, particularly in the context of dissemination, secondary colonization and/or persistence...
  9. ncbi Salp25D, an Ixodes scapularis antioxidant, is 1 of 14 immunodominant antigens in engorged tick salivary glands
    S Das
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8031, USA
    J Infect Dis 184:1056-64. 2001
    ..These results categorize the prominent salivary gland proteins in I. scapularis and demonstrate the presence of a potent antioxidant in tick saliva...
  10. ncbi Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology
    Sarah C Higgins
    Immune Regulation Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Immunol 171:3119-27. 2003
    ..pertussis, which both directly, and by promoting the induction of IL-10-secreting type 1 regulatory T cells, may inhibit Th1 responses and limit inflammatory pathology in the lungs during infection with B. pertussis...
  11. pmc Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks
    J Ohnishi
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 98:670-5. 2001
    ..burgdorferi transmission. Implicit in our model is the concept that tick transmission converts a homogeneous spirochete population into a heterogeneous population that is poised to infect the mammalian host...
  12. pmc Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability
    Huixing Wu
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    J Clin Invest 111:1589-602. 2003
    ....
  13. ncbi Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus
    S B Han
    Biopotency Evaluation Laboratory, Korea Research Institute of Bioscience and Biotechnology KRIBB, 52 Oundong, Yusong, Taejon 305 333, South Korea
    Int Immunopharmacol 3:1301-12. 2003
    ..senticosus, activates B cells and macrophages by interacting with TLRs and leading to the subsequent activation of mitogen-activated protein kinases and NF-kappaB...
  14. pmc Genetic variation at the vlsE locus of Borrelia burgdorferi within ticks and mice over the course of a single transmission cycle
    Jun Ohnishi
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Bacteriol 185:4432-41. 2003
    ..Although vlsE genetic diversity is maintained through tick stages, the VlsE protein is unlikely to be of functional importance in the vector, because the protein was expressed by very few (<1%) bacteria in the vector...
  15. pmc Altered dopaminergic profiles: implications for the regulation of voluntary physical activity
    Amy M Knab
    Department of Kinesiology, University of North Carolina, Charlotte, NC, USA
    Behav Brain Res 204:147-52. 2009
    ....
  16. ncbi MyD88 plays a unique role in host defense but not arthritis development in Lyme disease
    Devin D Bolz
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Immunol 173:2003-10. 2004
    ..The findings presented here point to a dichotomy between the recruitment of inflammatory cells to tissue and an inability of these cells to kill localized spirochetes...
  17. ncbi Coinoculation of Borrelia spp. with tick salivary gland lysate enhances spirochete load in mice and is tick species-specific
    N S Zeidner
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    J Parasitol 88:1276-8. 2002
    ..lusitaniae. Protein profile analysis indicated at least 5 major protein differences between I. scapularis and I. ricinus SGL, which can possibly account for this specific tick-spirochete interaction...
  18. pmc BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype
    Hiroki Kawabata
    Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    Infect Immun 72:7147-54. 2004
    ..The inactivation of BBE02 thus eliminates a transformation barrier for infectious B. burgdorferi B31 and will provide a valuable tool for studying the virulence factors of Lyme disease...
  19. ncbi Differential antigen processing by dendritic cell subsets in vivo
    Diana Dudziak
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    Science 315:107-11. 2007
    ..This difference in antigen processing is intrinsic to the DC subsets and is associated with increased expression of proteins involved in MHC processing...
  20. ncbi Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription
    A M Sangoram
    Department of Neurobiology and Physiology and National Science Foundation, Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Neuron 21:1101-13. 1998
    ..Taken together, these results demonstrate that mTim and hTIM are mammalian orthologs of timeless and provide a framework for a basic circadian autoregulatory loop in mammals...
  21. ncbi Transcription factor hierarchy in Waardenburg syndrome: regulation of MITF expression by SOX10 and PAX3
    S B Potterf
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 4472, USA
    Hum Genet 107:1-6. 2000
    ..Our data support a model in which the hypopigmentation in WS, of which these factors have been implicated, results from a disruption in function of the central melanocyte transcription factor MITF...
  22. pmc T-cell-independent responses to Borrelia burgdorferi are critical for protective immunity and resolution of lyme disease
    M D McKisic
    Center for Comparative Medicine, University of California, Davis, California 95616, USA
    Infect Immun 68:5190-7. 2000
    ..These data demonstrate that B-cell activation during a T-cell-independent response may be critical for resolution of arthritis and carditis and that protective antibodies are generated during this response...
  23. ncbi In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4
    G Baumgarten
    Department of Medicine, Cardiology Section, Winters Center for Heart Failure Research, and Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas, USA
    J Infect Dis 183:1617-24. 2001
    ..Activation of myocardial NF-kappaB was observed within 30 min in C3HeB/FeJ mice but not in C3H/HeJ mice. These findings suggest that myocardial TLR-4 is involved in signaling cytokine production within the heart during endotoxic shock...
  24. ncbi Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity
    Marciane Milanski
    Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil
    J Neurosci 29:359-70. 2009
    ....
  25. ncbi The extra domain A of fibronectin activates Toll-like receptor 4
    Y Okamura
    Center for Research on Reproduction and Women's Health, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Biol Chem 276:10229-33. 2001
    ..These observations provided a mechanism by which EDA-containing fibronectin fragments promote expression of genes involved in the inflammatory response...
  26. ncbi Genome-wide, large-scale production of mutant mice by ENU mutagenesis
    M H Hrabe de Angelis
    Institute of Experimental Genetics, GSF Research Center for Environment and Health, Neuherberg, Germany
    Nat Genet 25:444-7. 2000
    ..Our mutant lines are freely accessible to non-commercial users (for information, see http://www.gsf.de/ieg/groups/enu-mouse.html)...
  27. ncbi Bystander elimination of antigen loss variants in established tumors
    Michael T Spiotto
    Department of Pathology and the Committee on Immunology, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Med 10:294-8. 2004
    ..These results highlight the general importance of targeting the tumor stroma to prevent the escape of variant cancer cells...
  28. pmc Role of the BBA64 locus of Borrelia burgdorferi in early stages of infectivity in a murine model of Lyme disease
    Mahulena Maruskova
    South Texas Center for Emerging Infectious Diseases and Department of Biology, The University of Texas at San Antonio, San Antonio, Texas 7824, USA
    Infect Immun 76:391-402. 2008
    ..burgdorferi in select tissues. Infectivity analysis of the BBA64 mutant suggests that B. burgdorferi may utilize multiple determinants to establish infection in mammalian hosts...
  29. ncbi Regulatory role of Toll-like receptor 2 during infection with Trypanosoma cruzi
    Catherine Ropert
    Laboratory of Immunopathology, Centro de Pesquisas Rene Rachou, FIOCRUZ, Av Augusto de Lima 1715, Barro Preto, 30190 002 Belo Horizonte, MG, Brazil
    J Endotoxin Res 10:425-30. 2004
    ..cruzi parasites...
  30. ncbi In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain
    Jean Christophe Bambou
    INSERM, EMI 0212, 156 rue de Vaugirard, 75015 Paris, France
    J Biol Chem 279:42984-92. 2004
    ..These findings provide strong evidence that flagellin released by flagellated commensal bacteria in the intestinal lumen can induce a pro-inflammatory response in enterocytes in vivo...
  31. ncbi Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody
    Carine Asselin-Paturel
    Laboratory for Immunological Research, Schering Plough Research Institute, Dardilly, France
    J Immunol 171:6466-77. 2003
    ..The higher ability of 129Sv mice to produce IFN-alpha in vivo is related to a higher number of pDC, but also to a higher ability of pDC from 129Sv mice to produce IFN-alpha in vitro in response to viral stimulation...
  32. ncbi Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect
    Marzena Maka
    Institut fur Biochemie, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Dev Biol 277:155-69. 2005
    ..Our study suggests that Sox8 and Sox10 are jointly required for the maintenance of these vagal neural crest stem cells...
  33. ncbi BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop
    Georges Rawadi
    Proskelia Pharmaceuticals, Romainville, France
    J Bone Miner Res 18:1842-53. 2003
    ..The precise role of this cascade in osteoblast differentiation was examined. We show that a Wnt autocrine loop mediates the induction of alkaline phosphatase and mineralization by BMP-2 in pre-osteoblastic cells...
  34. ncbi An enteric helminth infection protects against an allergic response to dietary antigen
    Mohamed Elfatih H Bashir
    Mucosal Immunology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 169:3284-92. 2002
    ..Taken together, these results suggest that helminth-dependent protection against allergic disease involves immunoregulatory mechanisms that block production of allergen-specific IgE...
  35. ncbi A vector for expressing foreign genes in the brains and hearts of transgenic mice
    D R Borchelt
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21205 2196, USA
    Genet Anal 13:159-63. 1996
    ..The MoPrP.Xho vector should be very useful in strategies designed to overexpress a variety of wild-type and disease related mutant transgenes in the heart and brain...
  36. ncbi Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse
    M Frasson
    Laboratoire de Physiopathologie Retinienne, Clinique Ophthalmologique, Universite Louis Pasteur, Centre Hospitalier Regional Universitaire, Strasbourg, France
    Invest Ophthalmol Vis Sci 40:2724-34. 1999
    ..To evaluate the neuroprotective potential of glial cell line-derived neurotrophic factor (GDNF) in the retinal degeneration (rd/rd) mouse model of human retinitis pigmentosa...
  37. ncbi Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediators
    M D Lehner
    Biochemical Pharmacology, University of Konstanz, Konstanz, Germany
    J Immunol 166:5161-7. 2001
    ....
  38. pmc Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains
    Sheryl S Moy
    North Carolina STAART Center for Autism Research, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Behav Brain Res 176:4-20. 2007
    ..Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses...
  39. ncbi Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation
    P Cheung
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville 22908, USA
    Mol Cell 5:905-15. 2000
    ..Together, these results illustrate how the addition of multiple histone modifications may be coupled during the process of gene expression...
  40. ncbi "Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?
    Sabine M Hoelter
    Institute of Developmental Genetics, Helmholtz Center Munich German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany
    Front Biosci 13:5810-23. 2008
    ..These results emphasize the importance of comprehensive behavioural and physiological phenotyping...
  41. ncbi Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart
    Albert J Chong
    Division of Cardiothoracic Surgery, Department of Surgery, The University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    J Thorac Cardiovasc Surg 128:170-9. 2004
    ..We used C3H/HeJ mice, which express a nonfunctional toll-like receptor 4, to assess the pertinence of this receptor to tissue injury after reperfusion of ischemic myocardium...
  42. pmc Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    E Y Lin
    Department of Developmental and Molecular Biology, Center for the Study of Reproductive Biology and Women s Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Exp Med 193:727-40. 2001
    ..Our data suggest that agents directed at CSF-1/CSF-1R activity could have important therapeutic effects...
  43. pmc Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis
    Kenji Hata
    Department of Biochemistry, Osaka University Graduate School Faculty of Dentistry, Japan
    Mol Biol Cell 14:545-55. 2003
    ..Thus, BMP2 controls adipocytic differentiation by using two distinct signaling pathways that play differential roles in this process in C3H10T1/2 cells...
  44. pmc Complete protection against lethal Toxoplasma gondii infection in mice immunized with a plasmid encoding the SAG1 gene
    H V Nielsen
    Department of Mycobacteria and Parasitology, Statens Serum Institut, University of Copenhagen, Copenhagen, Denmark
    Infect Immun 67:6358-63. 1999
    ..In conclusion, DNA vaccination with p1tPASAG1 gave effective protection in mice against T. gondii infection and the protection could be adoptively transferred by purified CD8(+) T cells...
  45. pmc Genetic control of the innate immune response
    Christine A Wells
    Institute for Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia
    BMC Immunol 4:5. 2003
    ....
  46. ncbi Genetic background determines metabolic phenotypes in the mouse
    Marie France Champy
    Institut Clinique de la Souris, BP 10142, 67404, Illkirch Cedex, France
    Mamm Genome 19:318-31. 2008
    ....
  47. ncbi Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis
    Prashant S Patole
    Medizinische Poliklinik Innenstadt, University of Munich, Munich, Germany
    Kidney Int 68:2582-7. 2005
    ..Toll-like receptor-4 (TLR4) mutant mice infected with uropathogenic Escherichia coli lack renal CXCL2 mRNA expression, subsequent neutrophil recruitment, and renal abscess formation...
  48. ncbi Genetic influence on daily wheel running activity level
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina Charlotte, Charlotte 28223, USA
    Physiol Genomics 19:270-6. 2004
    ..In conclusion, these data indicate that daily running wheel activity level in mice is significantly affected by genetic background and sex...
  49. ncbi Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota
    Astrid Konrad
    Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    Gastroenterology 130:2050-9. 2006
    ..The normal host immune response to antigens of the enteric microbiota is poorly defined. In this study, we isolated recombinant microbial antigens from commensal bacteria and used them to probe the normal murine immune response...
  50. ncbi Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation
    J H Hong
    Department of Radiation Oncology, Chang Gung Memorial Hospital, Kwei Shan, Taoyuan, Taiwan
    Int J Radiat Biol 75:1421-7. 1999
    ..To investigate cytokine gene expression in the lung after single and fractionated doses of radiation, and to investigate the effect of steroids and the genetic background...
  51. ncbi Toxicogenomic analysis of aberrant gene expression in liver tumors and nontumorous livers of adult mice exposed in utero to inorganic arsenic
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC 27709, USA
    Toxicol Sci 77:249-57. 2004
    ..Some of these aberrantly expressed genes could play a role in the development of arsenic-induced tumors, at least in the liver...
  52. pmc Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli
    Joel D Schilling
    Department of Molecular Microbiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:4203-8. 2003
    ..These results demonstrated that bladder epithelial cells play a critical role in TLR4-mediated innate immunity in vivo during a mucosal bacterial infection...
  53. ncbi Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2
    Arya Biragyn
    Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Science 298:1025-9. 2002
    ..These events, in turn, trigger robust, type 1 polarized adaptive immune responses in vivo, suggesting that mDF2beta may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigens...
  54. ncbi Plasmid requirements for infection of ticks by Borrelia burgdorferi
    Keith O Strother
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Vector Borne Zoonotic Dis 5:237-45. 2005
    ..This study has pinpointed specific plasmids whose absence is deleterious to infecting nymphal tick guts and salivary glands...
  55. pmc Deletion of TolC orthologs in Francisella tularensis identifies roles in multidrug resistance and virulence
    Horacio Gil
    Center for Infectious Diseases, Stony Brook University, Stony Brook, NY 11794 5120, USA
    Proc Natl Acad Sci U S A 103:12897-902. 2006
    ..Thus, tolC is a critical virulence factor of F. tularensis in addition to its role in multidrug resistance, which suggests the presence of a functional type I secretion system...
  56. ncbi Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:7370-7. 2004
    ..Interactions of HMGB1 with TLR 2 and TLR 4 may provide an explanation for the ability of HMGB1 to generate inflammatory responses that are similar to those initiated by LPS...
  57. pmc Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks
    K E Hagman
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    Infect Immun 68:4759-64. 2000
    ..The failure of DbpA immunization to protect tick-challenged mice contradicts the results of earlier needle inoculation vaccination experiments and suggests that DbpA may not be suitable as a Lyme disease vaccine...
  58. ncbi CD14 is required for MyD88-independent LPS signaling
    Zhengfan Jiang
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Nat Immunol 6:565-70. 2005
    ..Thus, the TLR4-MD-2 complex receptor can function in two separate modes: one in which full signaling occurs and one limited to MyD88-dependent signaling...
  59. ncbi Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
    K Ohashi
    German Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    J Immunol 164:558-61. 2000
    ..We conclude that Tlr4 mediates hsp60 signaling. This is the first report of a putative endogenous ligand of the Tlr4 complex...
  60. ncbi Expression of connexin47 in oligodendrocytes is regulated by the Sox10 transcription factor
    Beate Schlierf
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Germany
    J Mol Biol 361:11-21. 2006
    ....
  61. pmc The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo
    Megan S Ford
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Multi Organ Transplantation Program, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada
    J Exp Med 196:261-7. 2002
    ..These findings clearly demonstrate that B6/lpr DNTC have a potent immune regulatory function in vitro and in vivo. They also provide new insights into the mechanisms involved in the development of autoimmune disease in lpr mice...
  62. ncbi Functional modifications in rod bipolar cells in a mouse model of retinitis pigmentosa
    Carolina Varela
    Department of Physiology, University of Alcala, Alcala de Henares, E 28871, Madrid, Spain
    Vision Res 43:879-85. 2003
    ..In our opinion, this work describes for the first time the changes in neurotransmitter sensitivity that affect rod bipolar cells after photoreceptor degeneration of the mouse retina...
  63. pmc Induction of immune cell infiltration into murine SCCVII tumour by photofrin-based photodynamic therapy
    G Krosl
    Cancer Imaging, British Columbia Cancer Research Centre, Vancouver, Canada
    Br J Cancer 71:549-55. 1995
    ..It seems, therefore, that the PDT-induced acute inflammatory infiltration of myeloid cells into the treated tumour is associated with functional activation of immune cells...
  64. ncbi The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster
    D H Lynch
    Department of Immunobiology, Immunex Research and Development Corporation, Seattle, Washington 98101
    Immunity 1:131-6. 1994
    ..Thus, the data demonstrate that the gld phenotype is the result of a point mutation in the Fasl gene and that Fasl is part of a complex of ligands structurally related to TNF mapping within a small region of mouse chromosome 1...
  65. pmc C-terminal invariable domain of VlsE is immunodominant but its antigenicity is scarcely conserved among strains of Lyme disease spirochetes
    F T Liang
    Department of Parasitology, Tulane Regional Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana 70433, USA
    Infect Immun 69:3224-31. 2001
    ..In contrast, antibody to the more conserved invariable region IR(6) of VlsE was present in all of these dog and human serum samples...
  66. ncbi The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    D M Underhill
    Department of Immunology, University of Washington, Seattle 98195, USA
    Nature 401:811-5. 1999
    ....
  67. ncbi Macrophage-independent fungicidal action of the pulmonary collectins
    Francis X McCormack
    Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
    J Biol Chem 278:36250-6. 2003
    ....
  68. ncbi Photodynamic therapy-mediated oxidative stress can induce expression of heat shock proteins
    C J Gomer
    Clayton Ocular Oncology Center, Childrens Hospital Los Angeles, California 90027, USA
    Cancer Res 56:2355-60. 1996
    ....
  69. ncbi Effects of mutations at the W locus (c-kit) on inner ear pigmentation and function in the mouse
    J Cable
    MRC Institute of Hearing Research, University Park, Nottingham, U K
    Pigment Cell Res 7:17-32. 1994
    ..Injection of normal neural crest cells into 9.5-day-old mutant embryos increased the extent of skin pigmentation on the head and coat of adult chimeras and was associated with a small increase in the proportion of pigmented strias...
  70. ncbi Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice
    Jun ichi Oyama
    Department of Cardiovascular Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Circulation 109:784-9. 2004
    ..This study assessed the role of TLR4 in myocardial infarction and inflammation in a murine model of ischemia-reperfusion injury...
  71. pmc Archaeosome vaccine adjuvants induce strong humoral, cell-mediated, and memory responses: comparison to conventional liposomes and alum
    L Krishnan
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario, Canada K1A 0R6
    Infect Immun 68:54-63. 2000
    ..Thus, archaeosomes may be potent vaccine carriers capable of facilitating strong primary and memory humoral, and cell-mediated immune responses to the entrapped antigen...
  72. pmc Time course and host responses to Escherichia coli urinary tract infection in genetically distinct mouse strains
    W J Hopkins
    Department of Surgery, University of Wisconsin, Madison, Wisconsin 43792, USA
    Infect Immun 66:2798-802. 1998
    ..The latter result strongly suggests that the presence or absence of specific host genes will determine how effectively an E. coli UTI will be resolved...
  73. ncbi Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains
    Junji Kamogawa
    Ehime University School of Medicine, Shigenobu, Onsen gun, Ehime, Japan
    Arthritis Rheum 46:1067-74. 2002
    ..To clarify the mode of inheritance and the genome origins of arthritis in a lupus-prone strain of mice, MRL/MpJ, bearing a Fas deletion mutant gene, lpr (MRL/lpr)...
  74. pmc Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo
    B Pulendran
    Baylor Institute for Immunology Research, Dallas, TX 75204, USA
    J Immunol 167:5067-76. 2001
    ..coli LPS, but not P. gingivalis LPS. Therefore, LPS from different bacteria activate DC subsets to produce different cytokines, and induce distinct types of adaptive immunity in vivo...
  75. ncbi Adhesion receptors on bone marrow stromal cells: in vivo expression of vascular cell adhesion molecule-1 by reticular cells and sinusoidal endothelium in normal and gamma-irradiated mice
    K Jacobsen
    Department of Anatomy and Cell Biology, McGill University, Montreal, Canada
    Blood 87:73-82. 1996
    ....
  76. pmc Bacterial protein secretion is required for priming of CD8+ T cells specific for the Mycobacterium tuberculosis antigen CFP10
    Joshua S Woodworth
    Division of Rheumatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Infect Immun 76:4199-205. 2008
    ..The implications of these findings should be considered in all models of antigen presentation during M. tuberculosis infection and in vaccine development...
  77. pmc RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants
    Melissa J Caimano
    Center for Microbial Pathogenesis, University of Connecticut Health Center, 263 Farmington Ave, Farmington 06030 3710, USA
    Infect Immun 72:6433-45. 2004
    ....
  78. ncbi The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation
    Xiao Dong Chen
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    FASEB J 18:948-58. 2004
    ..However, the response of bgn-deficient osteoblasts to BMP-4 was completely rescued by reintroduction of biglycan by viral transfection. We propose that biglycan modulates BMP-4-induced signaling to control osteoblast differentiation...
  79. pmc Peg5/Neuronatin is an imprinted gene located on sub-distal chromosome 2 in the mouse
    F Kagitani
    Gene Research Center, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226, Japan
    Nucleic Acids Res 25:3428-32. 1997
    ..Peg5/Neuronatin maps to sub-distal Chr 2, proximal to the previously established imprinted region where imprinted genes cause abnormal shape and behavior in neonates...
  80. ncbi IL-12 administration accelerates autoimmune diabetes in both wild-type and IFN-gamma-deficient nonobese diabetic mice, revealing pathogenic and protective effects of IL-12-induced IFN-gamma
    Sylvie Trembleau
    BioXell, Milan, Italy
    J Immunol 170:5491-501. 2003
    ..These data demonstrate that IFN-gamma has a dual role, pathogenic and protective, in IDDM development, and its deletion allows IL-12 to establish alternative pathways leading to diabetes acceleration...
  81. pmc Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein
    Celina V Zerbinatti
    Departments of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:1075-80. 2004
    ..These results provide in vivo evidence that LRP may contribute to memory deficits typical of Alzheimer's disease by modulating the pool of small soluble forms of Abeta...
  82. pmc Resistance to Lyme disease in decorin-deficient mice
    E L Brown
    The Center for Extracellular Matrix Biology, Texas A and M University System Health Science Center, Albert B Alkek Institute of Biosciences and Technology, Houston, Texas 77030, USA
    J Clin Invest 107:845-52. 2001
    ..These differences, which were observed regardless of genetic background of the mice (BALB/c or C3H/HeN) or method of infection, demonstrate the importance of decorin in the pathogenesis of LD...
  83. ncbi A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
    P M Nolan
    MRC Mammalian Genetics Unit and Mouse Genome Centre, Harwell, UK
    Nat Genet 25:440-3. 2000
    ..Our work, along with the programme reported in the accompanying paper, has led to a substantial increase in the mouse mutant resource and represents a first step towards systematic studies of gene function in mammalian genetics...
  84. ncbi Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase
    P H Roseboom
    Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 63:189-97. 1998
    ..The decrease in melatonin signaling may have been a selective factor in the development of laboratory strains of mice because melatonin can inhibit reproduction and modify circadian rhythmicity...
  85. ncbi Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation
    J N Murdoch
    Neural Development Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    Genomics 78:55-63. 2001
    ..8 cM on central chromosome 15. Partial penetrance of the craniorachischisis phenotype in Crc/+,Lp/+double heterozygotes suggests the existence of a third, unlinked genetic locus that influences the interaction between Crc and Lp...
  86. pmc CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
    Ian P Lewkowich
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Exp Med 202:1549-61. 2005
    ..These data suggest that resistance to allergen-driven AHR is mediated in part by CD4+CD25+ T reg cell suppression of DC activation and that the absence of this regulatory pathway contributes to susceptibility...
  87. ncbi A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host
    Joye E Purser
    Graduate School of Biomedical Sciences and Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, MSB 2 278, 6431 Fannin St, Houston, TX 77225, USA
    Mol Microbiol 48:753-64. 2003
    ..These results indicate that some plasmid-encoded products fulfil physiological functions required in the enzootic cycle of pathogenic Borrelia...
  88. pmc Tissue-specific expression and regulation of sexually dimorphic genes in mice
    Xia Yang
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Genome Res 16:995-1004. 2006
    ..Moreover, many tissue-specific transcription factor binding sites were found to be enriched in the sexually dimorphic genes...
  89. ncbi Bacterial lipoprotein induces resistance to Gram-negative sepsis in TLR4-deficient mice via enhanced bacterial clearance
    Gavin C O'Brien
    Department of Academic Surgery, National University of Ireland, Cork University Hospital, Cork, Ireland
    J Immunol 174:1020-6. 2005
    ..These results indicate that BLP, a TLR2 ligand, protects highly susceptible TLR4-deficient mice from Gram-negative sepsis via enhanced bacterial clearance...
  90. pmc Integrating genetic and network analysis to characterize genes related to mouse weight
    Anatole Ghazalpour
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
    PLoS Genet 2:e130. 2006
    ..Our approach results in the identification of genetic targets that influence gene modules (pathways) that are related to the clinical phenotypes of interest...
  91. pmc Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    Iris Caramalho
    Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
    J Exp Med 197:403-11. 2003
    ..These findings provide the first evidence that Treg respond directly to proinflammatory bacterial products, a mechanism that likely contributes to the control of inflammatory responses...
  92. ncbi Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region
    A Poltorak
    Howard Hughes Medical Institute, Dallas, TX 75235 9050, USA
    Blood Cells Mol Dis 24:340-55. 1998
    ..Only a single intact gene was identified within the entire critical region. This gene encodes the Toll-4 receptor, a member of the IL-1 receptor family...
  93. ncbi Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families
    Carl J Johnston
    University of Rochester, Department of Pediatrics, Environmental Medicine, and Radiation Oncology, Rochester, New York 14642, USA
    Radiat Res 157:256-65. 2002
    ..These studies suggest that monocyte/macrophage and lymphocyte recruitment and activation are key components of radiation-induced fibrosis...
  94. pmc Genetic variation for body weight change in mice in response to physical exercise
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    BMC Genet 10:58. 2009
    ....
  95. ncbi Toll-like receptor 4 in lymphatic endothelial cells contributes to LPS-induced lymphangiogenesis by chemotactic recruitment of macrophages
    Shinae Kang
    Graduate School of Medical Science and Engineering, Advanced Institute of Science and Technology KAIST, Daejeon, Republic of Korea
    Blood 113:2605-13. 2009
    ..In conclusion, TLR4 in LECs plays an essential role in LPS-induced inflammatory lymphangiogenesis by chemotactic recruitment of macrophages...
  96. ncbi Toll-like receptor 4-mediated activation of murine mast cells
    J D McCurdy
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Leukoc Biol 70:977-84. 2001
    ..These findings have important implications for the mechanism of mast cell responses to pathogens and their products and suggest that different TLR4-expressing cells might have different thresholds for activation with LPS...
  97. pmc Ipr1 gene mediates innate immunity to tuberculosis
    Hui Pan
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 667 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 434:767-72. 2005
    ..Our data indicate that the Ipr1 gene product might have a previously undocumented function in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death and pathogenesis...
  98. pmc Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks
    Girish Neelakanta
    Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 3:e33. 2007
    ..Taken together, these data suggest that OspB has an important role within Ixodes scapularis and that B. burgdorferi relies upon multiple genes to efficiently persist in ticks...
  99. ncbi Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms
    Sarah M Fortune
    Division of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 172:6272-80. 2004
    ..tuberculosis without inhibiting production of NO. These results imply that inhibition of macrophage responses to IFN-gamma may contribute to the inability of an apparently effective immune response to eradicate M. tuberculosis...
  100. ncbi A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    J Han
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 265:808-11. 1994
    ..Both HOG1 and p38 are tyrosine phosphorylated after extracellular changes in osmolarity. These findings link a signaling pathway in mammalian cells with a pathway in yeast that is responsive to physiological stress...
  101. pmc A phenotype-based screen for embryonic lethal mutations in the mouse
    A Kasarskis
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, and the Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:7485-90. 1998
    ..Two mutations produce novel early phenotypes and map to regions of the genome not previously implicated in embryonic patterning...

Research Grants64

  1. Variation in M. tuberculosis in response to host selection
    Sarah Fortune; Fiscal Year: 2009
    ..In these studies, we expect to provide fundamental insights into the mechanisms and targets of diversifying immune selection in M. tuberculosis. ..
  2. Role of TLR4 in Coronavirus Infection
    Steven M Varga; Fiscal Year: 2010
    ..This information will provide novel approaches for therapeutic intervention of respiratory coronavirus infections and aid in the design of future coronavirus vaccines. ..
  3. BORRELIA BURGDORFERI MITOGEN IN DEVELOPMENT OF ARTHRITIS
    Janis J Weis; Fiscal Year: 2013
    ..Preliminary studies suggest Lyme arthritis to be a versatile model for studying the in vivo role of microRNAs in inflammatory pathologies. ..
  4. Antibody-interferon fusion proteins for treatment of B-cell malignancies
    Sherie L Morrison; Fiscal Year: 2013
    ..B. Evaluate the in vivo efficacy of the fusion proteins against human lymphoma xenografts in combination with inhibitors of mTOR (temsirolimus) or PI3 kinase d (CAL-120). ..
  5. BORRELIA BURGDORFERI MITOGEN IN DEVELOPMENT OF ARTHRITIS
    Janis J Weis; Fiscal Year: 2012
    ..Understanding how distinct responses that influence disease outcome are activated by the same bacterial pathogen has global implications for understanding the development and control of inflammatory pathologies. ..
  6. Role of Deiodinases in Thyroid Hormone Homeostasis
    Ann M Zavacki; Fiscal Year: 2010
    ....
  7. MOLECULAR GENETICS OF LYME ARTHRITIS SUSCEPTIBILITY
    Janis J Weis; Fiscal Year: 2013
    ..burgdorferi signaling in macrophages. ..
  8. Role of B cells in the Cell-Mediated Immune Response to Leishmania amazonensis
    Katherine Nicole Gibson Corley; Fiscal Year: 2010
    ..These findings will also advance our understanding of genetic predispositions to leishmaniasis. ..
  9. H2 haplotype and atherosclerosis
    Weibin Shi; Fiscal Year: 2013
    ..We will determine whether deficiency in MDC1 would promote atherosclerosis following radiation. These studies will shed light on new genes and new pathways that control atherosclerosis susceptibility. ..
  10. Transplantation of Genetically Modified, Immune-privileged Steroli Cells
    Jannette M Dufour; Fiscal Year: 2012
    ..In the long-term these cells could provide an unlimited supply of genetically modified tissue that could be transplanted without the use of chronic immunosuppression as a means of treatment for multiple disorders. ..
  11. INNATE MECHANISMS OF MYCOPLASMAL KILLING BY ALVEOLAR MAC
    JUDY HICKMAN DAVIS; Fiscal Year: 2003
    ..abstract_text> ..
  12. Chronic Lyme Arthritis: Is this Autoimmunity?
    Brigitte Huber; Fiscal Year: 2005
    ..These experiments are designed to elucidate the mechanism of treatment resistant Lyme arthritis. ..
  13. GENETIC LINKAGE OF AUDITORY GATING
    Karen Stevens; Fiscal Year: 2001
    ..Such information could be important in understanding of the etiology of the disorder and in determining future therapeutic interventions. ..
  14. HYPERTHERMIC SENSITIZERS AND RADIOTHERAPY
    Jae Ho Kim; Fiscal Year: 1990
    ....
  15. Mucosal immune regulation in murine amebic colitis
    Eric Houpt; Fiscal Year: 2007
    ..The comprehensive approach in training and research laid out in this research proposal will guide the applicant towards his goal of being an independent investigator in immunoparasitology. ..
  16. X-RAY & HEAT INTERACTIONS & MURINE JEJUNAL FIBROSIS
    Jeffrey Peck; Fiscal Year: 1992
    ..Risks attendant use of hyperthermia in retreatment will be quantified by both tensile testing and blood-flow (133-Xe clearance technique) measurements...
  17. The Influence of Sex on the Circadian Response to Methamphetamine
    JENNIFER MOHAWK; Fiscal Year: 2009
    ....
  18. Novel pathways in Retroviral Tumorigenesis
    Tatyana Golovkina; Fiscal Year: 2009
    ..Relevance to public health: The proposed studies will provide fundamental insights into signal transduction pathway involved in mammary gland tumorigenesis and ultimately help to identify potential targets for anti-tumor chemotherapy. ..
  19. Deiodinases in Thyroid Hormone Homeostasis
    ANN ZAVACKI; Fiscal Year: 2006
    ..This experience will help her achieve her long-term goal of becoming an independent biomedical scientist. ..
  20. EXPERIMENTAL RADIOTHERAPY--CARCINOGENESIS, AND PROTECTOR
    DAVID GRDINA; Fiscal Year: 2003
    ..abstract_text> ..
  21. INITIATION--PROMOTION BIOASSAY IN MOUSE LIVER
    Michael Pereira; Fiscal Year: 1990
    ....
  22. ADOLESCENT ETOH WITHDRAWAL: EFFECT ON ADULT RESPONSE
    Danielle Graham; Fiscal Year: 2001
    ..These findings may have important implications with regard to the effects of adolescent alcohol abuse on EtOH-related behaviors in adulthood. ..
  23. MAMMARY GLAND GLYCOSAMINOGLYCAN STRUCTURE AND TURNOVER
    Jay Umbreit; Fiscal Year: 1991
    ..Such an understanding may ultimately suggest new approaches to cancer prevention and treatment...
  24. Development/Bifunctional MR Agents/Diagnosis and Therapy
    Ravindra Pandey; Fiscal Year: 2007
    ..abstract_text> ..
  25. Development/Bifunctional MR Agents/Diagnosis and Therapy
    Ravindra Pandey; Fiscal Year: 2005
    ..abstract_text> ..
  26. DYSREGULATION OF IL12 IN ALLERGIC INFLAMMATION
    Marsha Wills Karp; Fiscal Year: 2000
    ....
  27. Taurine: EtOH Withdrawal Attenuation via AVP Moduation
    ANDRE ZALUD; Fiscal Year: 2006
    ..As a result, data collected from these studies could provide evidence that supports the therapeutic use of taurine in alcoholism. ..
  28. Asthma Positional Candidate Genes in Mice and Humans
    Marsha Wills Karp; Fiscal Year: 2010
    ..abstract_text> ..
  29. NOVEL DELIVERY SYSTEM FOR A HERPESVIRUS DNA VACCINE
    NANCY BIGLEY; Fiscal Year: 1999
    ..Conditions for stimulating optimal HSV CTL responses will be defined by this study. The practical application of this novel approach is a therapy for alleviating recurrences of painful herpes lesions in humans. ..
  30. OPTIMIZATION OF RADIATION THERAPY
    LYLE DETHLEFSEN; Fiscal Year: 1980
    ..These studies on both normal and malignant tissues are done for adriamycin alone, x-irradiation alone and combined treatments with various intervals of time between modalities...
  31. Sono-Contrast Induced Functional Imaging/Spectroscopy
    Yan Yu; Fiscal Year: 2004
    ..abstract_text> ..
  32. Sono-Contrast Induced Functional Imaging/Spectroscopy
    Yan Yu; Fiscal Year: 2007
    ..abstract_text> ..
  33. VASCULARITY AND REOXYGENATION IN X-IRRADIATED TUMORS
    Chang Song; Fiscal Year: 2000
    ..From the increase in tumor response and the increase in damage in normal tissue (foot), the therapeutic value of MTH alone or in combination with other agents will be assessed. ..
  34. T CELL RESPONSES IN THE EVOLUTION OF LYME DISEASE
    Linda Bockenstedt; Fiscal Year: 2000
    ..The requirement for B cells for exertion of the effect of T cells will also be determined. Thus, these studies will provide information on all aspects of the role of the T cell in murine Lyme disease. ..
  35. GENETIC RESISTANCE TO LETHAL FLAVIVIRAL ENCEPHALITIS
    Abigail Smith; Fiscal Year: 1980
    ..Finally, the hypothesis that qualitative and/or quantitative differences may exist between the 2 strains in cell membrane virus receptors on target cells in the brain and lymphoid tissues will be examined...
  36. CYTOTOXIC T CELL RECOGNITION OF THE SV40 TUMOR ANTIGEN
    Linda Gooding; Fiscal Year: 1990
    ..Together these studies are designed to evaluate the rules by which CTL select immunogenic epitopes within a tumor-associated antigen with the long-term goal of developing strategies for the manipulation of the antitumor immune response...
  37. CYSTEINE PROTEINASES AS LEISHMANIAL VIRULENCE FACTORS
    LAURENCE BUXBAUM; Fiscal Year: 2002
    ..D. and Ph.D. degrees, with thesis research in the GPI anchor of African trypanosomes. He has completed his clinical training in Internal Medicine and a clinical year of Infectious Diseases at the University of Pennsylvania. ..
  38. VOLUNTARY EXERCISE AS MEANS OF MAMMARY CANCER PREVENTION
    Leonard Cohen; Fiscal Year: 1991
    ....
  39. CHEMICAL TRANSFORMATION OF PROSTATE EPITHELIAL CELLS
    CHARLES HEIDELBERGER; Fiscal Year: 1980
    ..A series of transplantable rat prostate tumors are being maintained in vivo and cultured. The status of their androgen and estrogen receptors will be compared with their growth characteristics in vivo...
  40. The Osteoprogenitor Lineage
    David Rowe; Fiscal Year: 2004
    ..The strategies, reagents and protocols that prove to be valuable to defining lineage performance and molecular pathways will be accessible from a web interface. ..
  41. IGF AXIS IN PROSTATE CANCER--TRANSGENIC STUDY
    Norman Greenberg; Fiscal Year: 2003
    ..abstract_text> ..
  42. TUMOR & NORMAL TISSUE RESPONSE TO HEAT AND RADIATION
    EDWARD GILLETTE; Fiscal Year: 1980
    ..Evaluations of skin response of treated mice will be done. In vitro experiments will be done with Chinese hamster ovary cells, and C3H mouse tumor cells...
  43. Treatment and Gene/Protein Analysis of Ethanol Relapse
    Howard Becker; Fiscal Year: 2007
    ....
  44. CHEMOKINES/CYTOKINES AND RECEPTORS IN STEM CELL HOMING
    Hal Broxmeyer; Fiscal Year: 2005
    ..These studies should clarity the relevance of SDF-1 and CXCR4 for homing/engraftment and mobilization of primary stem/progenitor cells. ..
  45. Innate immunity and experimental Lyme arthritis
    Charles Brown; Fiscal Year: 2007
    ..As such these studies; may have important implications not only for Lyme disease, but for other inflammatory diseases as well. ..
  46. Eicosanoid regulation of experimental Lyme arthritis
    Charles R Brown; Fiscal Year: 2010
    ..This information will further our understanding of how inflammation is regulated and allow the design of more effective anti-inflammatory treatments. ..
  47. QTL analysis of carotid atherosclerosis
    Weibin Shi; Fiscal Year: 2007
    ..One to two major QTLs for atherosclerotic lesions will be dissected through construction of congenic strains. ..
  48. Regulation of atherosclerosis susceptibility.
    Weibin Shi; Fiscal Year: 2006
    ..In Specific Aim 4, we will conduct molecular analysis to characterize the causative genes residing in the chromosomal regions that influence atherosclerotic lesion formation. [unreadable] [unreadable]..
  49. Genetic analysis of neointimal hyperplasia
    Weibin Shi; Fiscal Year: 2009
    ..One to two major QTLs for neointimal hyperplasia will be dissected through construction and analysis of congenic strains. ..
  50. QUANTITATION OF HYPOXIC TUMOR CELLS
    Peggy Olive; Fiscal Year: 2001
    ..To validate the models, expression of GFP will be analyzed in relation to proliferation, hypoxia marker binding, and clonogenicity following irradiation. ..
  51. IL-15, Body Compositition and Insulin Sensivity in Aging
    LeBris S Quinn; Fiscal Year: 2010
    ..abstract_text> ..
  52. Prevention of skin cancer by green tea polyphenols
    Santosh Katiyar; Fiscal Year: 2009
    ..Importantly, worldwide interest in green tea as a cancer chemopreventive agent for humans is increasing because it is non-toxic, affordable, popular beverage and is effective in a wide range of organs. ..
  53. Cholinergic Modulation of Inflammatory CNS Cytokines
    LORISE GAHRING; Fiscal Year: 2006
    ..abstract_text> ..
  54. INTESTINAL T-REGULATORY-1 CELLS IN MUCOSAL HOMEOSTASIS
    CHARLES ELSON; Fiscal Year: 2006
    ..Our long-term goal is an understanding of Tr1 cells sufficient to manipulate this subset as a novel therapy for human intestinal inflammatory diseases. ..
  55. HELICOBACTER DIAGNOSTIC ASSAYS FOR LABORATORY MICE
    Stephen Barthold; Fiscal Year: 2004
    ..abstract_text> ..
  56. URINARY TRACT INFECTIONS--IMMUNE BASIS OF SUSCEPTIBILITY
    WALTER HOPKINS; Fiscal Year: 2003
    ....
  57. Abnormalities of Mitochondria in Chagasic Myocarditis
    Nisha Garg; Fiscal Year: 2003
    ..The proposed studies will determine the pathophysiological contribution of host mitochondrial abnormalities in the progression of chagas disease. ..
  58. Genomics of Susceptibility to Urinary Tract Infections
    WALTER HOPKINS; Fiscal Year: 2007
    ..coli strains or non-E, coil bacteria. These objectives will be accomplished using a well-established mouse model of ascending UTI, genetic linkage analysis, and evaluation of resistance to uropathogens in congenic mice. ..
  59. Prevention of Photocarcinogenesis by antioxidant
    Santosh Katiyar; Fiscal Year: 2003
    ..abstract_text> ..
  60. 5th Comparative Medicine Resource Center Director Mtg.
    Stephen Barthold; Fiscal Year: 2008
    ....
  61. 3RD ANNUAL MUTANT MOUSE REGIONAL RESOURCE CENTER MEETING
    Stephen Barthold; Fiscal Year: 2003
    ....
  62. 11th International Congress of Mucosal Immunology
    CHARLES ELSON; Fiscal Year: 2002
    ..Support for young investigators is critical because they represent the future of the field. ..
  63. TUMOR OXYGENATION, VASCULARIZATION, AND RADIORESPONSE
    Bruce Fenton; Fiscal Year: 2009
    ..These results with lead to the more rational and optimal design of effective combined therapies, thereby ultimately accelerating their implementation into clinical protocols. ..
  64. Acellular vaccines against Francisella tularensis
    Wayne Conlan; Fiscal Year: 2005
    ..It is expected that the findings from the proposed studies will be applicable to the development of acellular vaccines against other intracellular respiratory pathogens such as Mycobacterium tuberculosis, and Chlamydia pneumoniae. ..