inbred balb c mice

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Top Publications

  1. ncbi The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
  2. pmc A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Exp Med 204:1757-64. 2007
  3. ncbi T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    Thorsten R Mempel
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:154-9. 2004
  4. ncbi An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    M B Lutz
    Department of Dermatology, University of Erlangen, Germany
    J Immunol Methods 223:77-92. 1999
  5. ncbi Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 17:375-87. 2002
  6. pmc Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    T Takahashi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 192:303-10. 2000
  7. ncbi The immunology of susceptibility and resistance to Leishmania major in mice
    David Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:845-58. 2002
  8. ncbi Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
    Bo Huang
    Departments of Gene and Cell Medicine and General Surgery, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Res 66:1123-31. 2006
  9. ncbi IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    M M Fort
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 15:985-95. 2001
  10. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004

Detail Information

Publications406 found, 100 shown here

  1. ncbi The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
    ..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases...
  2. pmc A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    Janine L Coombes
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    J Exp Med 204:1757-64. 2007
    ..These results newly identify RA as a cofactor in T reg cell generation, providing a mechanism via which functionally specialized gut-associated lymphoid tissue DCs can extend the repertoire of T reg cells focused on the intestine...
  3. ncbi T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    Thorsten R Mempel
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:154-9. 2004
    ....
  4. ncbi An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
    M B Lutz
    Department of Dermatology, University of Erlangen, Germany
    J Immunol Methods 223:77-92. 1999
    ..This method allows by simple means the generation of high numbers of murine DC with very low B cell or granulocyte contaminations. It will be valuable to study DC biology notably at the molecular level...
  5. ncbi Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Immunity 17:375-87. 2002
    ..Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses...
  6. pmc Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    T Takahashi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 192:303-10. 2000
    ..This unique function of CTLA-4 could be exploited to potentiate T cell-mediated immunoregulation, and thereby to induce immunologic tolerance or to control autoimmunity...
  7. ncbi The immunology of susceptibility and resistance to Leishmania major in mice
    David Sacks
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Immunol 2:845-58. 2002
    ..major-resistant mice have revealed complexities in the mechanisms responsible for acquired immunity, which necessitate the redesign of vaccines against Leishmania and other pathogens that require sustained cell-mediated immune responses...
  8. ncbi Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
    Bo Huang
    Departments of Gene and Cell Medicine and General Surgery, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Cancer Res 66:1123-31. 2006
    ..Our data provide evidence that Gr-1(+)CD115(+) MSC can mediate the development of Treg in tumor-bearing mice and show a novel immune suppressive mechanism by which MSCs can suppress antitumor responses...
  9. ncbi IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    M M Fort
    DNAX Research Institute, Palo Alto, CA 94304, USA
    Immunity 15:985-95. 2001
    ..These results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types...
  10. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
  11. ncbi OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    Y Y Kong
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 397:315-23. 1999
    ..Thus OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo...
  12. ncbi CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice
    Damo Xu
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, Scotland, United Kingdom
    J Immunol 170:394-9. 2003
    ..Our results therefore document that CD4+CD25+ regulatory T cells suppress both Th1 and Th2 cells and that these regulatory T cells have a profound therapeutic potential against diseases induced by both Th1 and Th2 cells in vivo...
  13. ncbi CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    Rebecca S McHugh
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:311-23. 2002
    ..Importantly, antibodies to GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset...
  14. pmc Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    D F Fiorentino
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304
    J Exp Med 170:2081-95. 1989
    ..The potential role of CSIF in crossregulation of Th1 and Th2 responses is discussed...
  15. ncbi Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
    ..This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage...
  16. ncbi PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    Y Latchman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 2:261-8. 2001
    ..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses...
  17. ncbi Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti
    Alexander S Pym
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris, Cedex 15, France
    Mol Microbiol 46:709-17. 2002
    ..Knocking-in five other RD loci did not affect the virulence of BCG. This study describes a genetic lesion that contributes to safety and opens new avenues for vaccine development...
  18. pmc Chitin induces accumulation in tissue of innate immune cells associated with allergy
    Tiffany A Reese
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 447:92-6. 2007
    ..Chitin is a recognition element for tissue infiltration by innate cells implicated in allergic and helminth immunity and this process can be negatively regulated by a vertebrate chitinase...
  19. pmc In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
    Yasushi Itoh
    Department of Pathology, Shiga University of Medical Science, Ohtsu, Shiga 520 2192, Japan
    Nature 460:1021-5. 2009
    ..Finally, we show that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic...
  20. ncbi Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    H Nishimura
    Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan
    Immunity 11:141-51. 1999
    ..Collectively, it is suggested that PD-1 is involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses...
  21. ncbi HMG-1 as a late mediator of endotoxin lethality in mice
    H Wang
    Department of Emergency Medicine and Department of Surgery, North Shore University Hospital New York University School of Medicine, Manhasset, NY 11030, USA
    Science 285:248-51. 1999
    ..Septic patients who succumbed to infection had increased serum HMG-1 levels, suggesting that this protein warrants investigation as a therapeutic target...
  22. ncbi G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Immunol 3:687-94. 2002
    ..We suggest that manipulation of SDF-1 CXCR4 interactions may be a means with which to control the navigation of progenitors between the BM and blood to improve the outcome of clinical stem cell transplantation...
  23. ncbi Cloning of a new cytokine that induces IFN-gamma production by T cells
    H Okamura
    Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan
    Nature 378:88-91. 1995
    ..IGIF may be involved in the development of Th1 cells and also in mechanisms of tissue injury in inflammatory reactions...
  24. pmc New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis
    J Tian
    Liver Cancer Institute and Zhong Shan Hospital, Shanghai Medical University, Peoples Republic of China
    Br J Cancer 81:814-21. 1999
    ..PCR products of HBsAg and HBxAg were both positive. The cell line MHCC97 still retained some characteristic features of original tumour. Establishment of cell line MHCC97 should be beneficial to the studies of HCC metastatic mechanisms...
  25. ncbi Expression of programmed death 1 ligands by murine T cells and APC
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 169:5538-45. 2002
    ..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation...
  26. ncbi Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo
    Pascale Kropf
    Department of Immunology, Faculty of Medicine, Imperial College London, UK
    FASEB J 19:1000-2. 2005
    ..To address the underlying mechanisms, the arginase-induced L-arginine catabolism was investigated and the results demonstrate that arginase regulates parasite growth directly by affecting the polyamine synthesis in macrophages...
  27. ncbi Control of regulatory T cell development by the transcription factor Foxp3
    Shohei Hori
    Laboratory of Immunopathology, Research Center for Allergy and Immunology, Institute for Physical and Chemical Research, Yokohama 230 0045, Japan
    Science 299:1057-61. 2003
    ..Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells...
  28. pmc Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
    Q Wang
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 93:3444-9. 1996
    ..Definitive erythropoiesis and myelopoiesis do not occur in Cbfa2-deficient embryos, and disruption of one copy of the Cbfa2 gene significantly reduces the number of progenitors for erythroid and myeloid cells...
  29. ncbi Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    Sandra S Diebold
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 303:1529-31. 2004
    ..These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses...
  30. ncbi T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    S P Schoenberger
    Department of Immunohematology and Blood Bank, University Hospital Leiden, The Netherlands
    Nature 393:480-3. 1998
    ..Blockade of CD40L inhibits CTL priming; this inhibition is overcome by signalling through CD40. CD40-CD40L interactions are therefore vital in the delivery of T-cell help for CTL priming...
  31. ncbi CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    R Forster
    Molecular Tumorgenetics and Immunogenetics, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Cell 99:23-33. 1999
    ..Thus, in order to bring together lymphocytes and dendritic cells to form the characteristic microarchitecture of secondary lymphoid organs, CCR7 is required to rapidly initiate an adoptive immune response...
  32. ncbi Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity
    Andrea Jegerlehner
    Cytos Biotechnology, Schlieren, Switzerland
    J Immunol 172:5598-605. 2004
    ....
  33. ncbi Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein
    Suzanne L Epstein
    Laboratory of Immunology and Developmental Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Bethesda, MD 20852, USA
    Vaccine 23:5404-10. 2005
    ..Thus, gene-based vaccination with NP may contribute to protective immunity against diverse influenza viruses through its ability to stimulate cellular immunity...
  34. pmc Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
    Padraic G Fallon
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 203:1105-16. 2006
    ..We demonstrate that these IL-25-regulated cells appear rapidly in the draining lymph nodes, implicating them as a source of type 2 cytokines during initiation of worm expulsion...
  35. pmc In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens
    Steffen Jung
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunity 17:211-20. 2002
    ..e., the sensitization of the immune system for cell-associated antigens. DC-depleted mice fail to mount CTL responses to infection with the intracellular bacterium Listeria monocytogenes and the rodent malaria parasite Plasmodium yoelii...
  36. ncbi The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
    Patricia A Taylor
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone Marrow Transplantation, Minneapolis 55455, USA
    Blood 99:3493-9. 2002
    ..CD4(+)CD25(+) cells warrant consideration as an exciting new modality of cellular therapy for the inhibition of undesirable autologous and allogeneic responses...
  37. ncbi Arthritis critically dependent on innate immune system players
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    Immunity 16:157-68. 2002
    ..We suggest that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response...
  38. pmc B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells
    S Y Tseng
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Exp Med 193:839-46. 2001
    ..These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses...
  39. ncbi The role of IL-10 in promoting disease progression in leishmaniasis
    M M Kane
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Immunol 166:1141-7. 2001
    ..This IgG allows amastigotes to exploit the antiinflammatory effects of Fc gamma R ligation to induce the production of IL-10, which renders macrophages refractory to the activating effects of IFN-gamma...
  40. ncbi Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
    H Nishimura
    Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo, Kyoto, 606 8501, Japan
    Science 291:319-22. 2001
    ..These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases...
  41. ncbi Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
    O Akbari
    Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, CA 94305-5208, USA
    Nat Immunol 2:725-31. 2001
    ..These studies show that IL-10 production by DCs is critical for the induction of tolerance, and that phenotypically mature pulmonary DCs mediate tolerance induced by respiratory exposure to antigen...
  42. pmc Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, Via Vincenzo Vela 6, CH 6500 Bellinzona, Switzerland
    J Exp Med 198:615-21. 2003
    ..These results indicate that DC number and tissue inflammation are critical parameters for DC-based vaccination...
  43. ncbi Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
    M S Jordan
    The Wistar Institute, Philadelphia, PA 19104, USA
    Nat Immunol 2:301-6. 2001
    ..Our findings indicate that specificity for self-peptides directs the selection of CD4+CD25+ regulatory thymocytes by a process that is distinct from positive selection and deletion...
  44. ncbi Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites
    Fred D Finkelman
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Immunol Rev 201:139-55. 2004
    ....
  45. pmc High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
    U Andersson
    Department of Medicine, Rheumatology Unit, Karolinska Hospital, 17176 Stockholm, Sweden
    J Exp Med 192:565-70. 2000
    ..Together, these results indicate that, like other cytokine mediators of endotoxin lethality (e.g., TNF and IL-1), extracellular HMG-1 is a regulator of monocyte proinflammatory cytokine synthesis...
  46. pmc Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
    Elin Jaensson
    Immunology Section, BMC D14, 221 84 Lund University, Lund, Sweden
    J Exp Med 205:2139-49. 2008
    ..Thus, small intestinal CD103(+) DCs represent a potential novel target for regulating human intestinal inflammatory responses...
  47. pmc Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    S J Szabo
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 185:817-24. 1997
    ..Thus, IFN-gamma may prevent early Th cells from premature commitment to the Th2 pathway. Controlling the expression of the IL-12R beta 2 subunit could be an important therapeutic target for the redirection of ongoing Th cell responses...
  48. ncbi Organ-specific disease provoked by systemic autoimmunity
    V Kouskoff
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, Illkirch, France
    Cell 87:811-22. 1996
    ..We suggest that human RA develops by an analogous mechanism...
  49. ncbi IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice
    P Launois
    World Health Organization Immunology Research and Training Center, University of Lausanne, Epalinges, Switzerland
    Immunity 6:541-9. 1997
    ..Thus, the IL-4 required for Th2 development and susceptibility to L. major is produced by a restricted population of V beta 4 V alpha 8 CD4+ T cells after cognate interaction with a single antigen from this complex organism...
  50. ncbi Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    Manuela Battaglia
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    Blood 105:4743-8. 2005
    ..Based on this new mode of action, rapamycin can be used to expand CD4(+)CD25(+)FoxP3(+) Tr cells for ex vivo cellular therapy in T-cell-mediated diseases...
  51. pmc Construction, characterization, and use of two Listeria monocytogenes site-specific phage integration vectors
    Peter Lauer
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720 3202, USA
    J Bacteriol 184:4177-86. 2002
    ..The PSA prophage DNA sequence reconstitutes a complete tRNA(Arg) gene. The modified vector, pPL2, was integration proficient at the same frequency as pPL1 in common laboratory serotype 1/2 strains as well as serotype 4b strains...
  52. pmc Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
    Giovanna Gallina
    Istituto Oncologico Veneto, Padua, Italy
    J Clin Invest 116:2777-90. 2006
    ..Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions...
  53. pmc Suppression of allergic airway inflammation by helminth-induced regulatory T cells
    Mark S Wilson
    Institute of Immunology and Infection Research, University of Edinburgh, UK
    J Exp Med 202:1199-212. 2005
    ..These data support the contention that helminth infections elicit a regulatory T cell population able to down-regulate allergen induced lung pathology in vivo...
  54. pmc Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    K Nakamura
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 194:629-44. 2001
    ..This, plus the fact that we could find no evidence that a soluble factor mediates suppression, strongly suggests that CD4(+)CD25(+) T cells exert immunosuppression by a cell-cell interaction involving cell surface TGF-beta1...
  55. ncbi Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells
    O Mandelboim
    The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassha Medical School, Jerusalem, Israel
    Nature 409:1055-60. 2001
    ..These findings indicate how NKp46-expressing NK cells may recognize target cells infected by influenza or parainfluenza without the decreased expression of target-cell MHC class I protein...
  56. ncbi A multigenic program mediating breast cancer metastasis to bone
    Yibin Kang
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Cell 3:537-49. 2003
    ....
  57. ncbi Regulation of antigen-specific CD8+ T cell homeostasis by perforin and interferon-gamma
    V P Badovinac
    Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA
    Science 290:1354-8. 2000
    ..Thus, perforin and IFN-gamma regulate distinct elements of CD8+ T cell homeostasis independently of their role as antimicrobial effector molecules...
  58. ncbi Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens
    F Martin
    Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 14:617-29. 2001
    ....
  59. doi Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 39:192-206. 2009
    ..These CD4(+)Foxp3(+) Treg cells are predominantly recruited from the 'natural' regulatory pool and act to inhibit protective immunity over the full course of infection...
  60. ncbi Deacetylase inhibition promotes the generation and function of regulatory T cells
    Ran Tao
    Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine and Biesecker Center for Studies of Pediatric Liver Diseases, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4318, USA
    Nat Med 13:1299-307. 2007
    ..Our data show that use of HDACi allows the beneficial pharmacologic enhancement of both the numbers and suppressive function of Foxp3(+) T(reg) cells...
  61. ncbi New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25
    Stephen D Hurst
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 169:443-53. 2002
    ..Further, these data demonstrate the heterogeneity of function within the IL-17 cytokine family and suggest that IL-25 may be an important mediator of allergic disease via production of IL-4, IL-5, IL-13, and eotaxin...
  62. ncbi The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites
    Kota Arun Kumar
    Michael Heidelberger Division of Immunology, Department of Pathology, New York University School of Medicine, New York, New York 10016, USA
    Nature 444:937-40. 2006
    ..Thus, although hundreds of other Plasmodium genes are expressed in sporozoites and EEFs, CS is a dominant protective antigen. Nevertheless, sterile immunity could be obtained by immunization of CS transgenics with three doses of IrSp...
  63. pmc Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major
    Pascale Kropf
    Faculty of Medicine, Department of Immunology, Imperial College London, London, United Kingdom
    Infect Immun 72:1920-8. 2004
    ..This is the first study showing that TLR4 contributes to the effective control of Leishmania infection in vivo...
  64. ncbi Stromal cells direct local differentiation of regulatory dendritic cells
    Mattias Svensson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Immunity 21:805-16. 2004
    ..The ability of tissue stromal cells to direct the development of DC with a regulatory phenotype thus provides a new mechanism for local immune regulation...
  65. pmc IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    Thomas Korn
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 448:484-7. 2007
    ..We show that an IL-2 cytokine family member, IL-21, cooperates with TGF-beta to induce T(H)17 cells in naive Il6-/- T cells and that IL-21-receptor-deficient T cells are defective in generating a T(H)17 response...
  66. pmc Epigenetic control of the foxp3 locus in regulatory T cells
    Stefan Floess
    Experimentelle Rheumatologie, Charite Universitaetsmedizin Berlin, Berlin, Germany
    PLoS Biol 5:e38. 2007
    ....
  67. ncbi B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation
    F Borriello
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Immunity 6:303-13. 1997
    ..Thus, B7-2 has an important role in initiating antibody responses in the absence of adjuvant, but the induction of B7-1 by adjuvant in B7-2-deficient mice can compensate for the absence of B7-2...
  68. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
    ..These results establish a mechanistic link between Twist, EMT, and tumor metastasis...
  69. ncbi A novel transcription factor, T-bet, directs Th1 lineage commitment
    S J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cell 100:655-69. 2000
    ..Thus, T-bet initiates Th1 lineage development from naive Thp cells both by activating Th1 genetic programs and by repressing the opposing Th2 programs...
  70. pmc Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
    Marcello Chieppa
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:2841-52. 2006
    ..Collectively, these findings support a model in which epithelial cell TLR signaling upon exposure to microbial stimuli induces active DC sampling of the gut lumen at sites distant from organized lymphoid tissues...
  71. ncbi Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsion
    Laura J Cliffe
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Science 308:1463-5. 2005
    ..This host protective mechanism against intestinal pathogens has implications for our wider understanding of the multifunctional role played by intestinal epithelium in mucosal defense...
  72. ncbi Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling
    Jill R Johnson
    Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, Millennium Pharmaceuticals, Cambridge, Massachusetts, USA
    Am J Respir Crit Care Med 169:378-85. 2004
    ..Finally, these responses were studied for up to 9 weeks after cessation of HDM exposure. We observed that whereas airway inflammation resolved fully, the remodeling changes did not resolve and airway hyperreactivity resolved only partly...
  73. pmc Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    Yoshiko Iwai
    Department of Medical Chemistry, Graduate School of Medicine, Japan Science and Technology Corporation, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 99:12293-7. 2002
    ....
  74. ncbi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    Jun Shimizu
    Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Nat Immunol 3:135-42. 2002
    ..Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease...
  75. pmc Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells
    Giorgio Napolitani
    Institute for Research in Biomedicine, Oncology Institute of Southern Switzerland, CH 6500, Bellinzona, Switzerland
    Nat Immunol 6:769-76. 2005
    ..These results identify a 'combinatorial code' by which DCs discriminate pathogens and suggest new strategies for promoting T helper type 1 responses...
  76. pmc T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    Keiji Hirota
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 204:41-7. 2007
    ..Extrinsic or intrinsic stimuli further expand these cells, thereby triggering autoimmune disease. Intervention in these events at cellular and molecular levels is useful to treat and prevent autoimmune disease, in particular RA...
  77. ncbi Migration of Plasmodium sporozoites through cells before infection
    M M Mota
    Department of Pathology, New York University School of Medicine, 341 East 25 Street, New York, NY 10010, USA
    Science 291:141-4. 2001
    ..Sporozoite migration through several cells in the mammalian host appears to be essential for the completion of the life cycle...
  78. pmc Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation
    Petra Hoffmann
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, CA 94305, USA
    J Exp Med 196:389-99. 2002
    ..Our results demonstrate that the balance of donor-type CD4(+)CD25(+) T(reg) and conventional CD4(+)CD25(-) T cells can determine the outcome of aGVHD...
  79. doi Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning
    I D Iliev
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Mucosal Immunol 2:340-50. 2009
    ..Thus, we have uncovered an essential mechanism in which EC control of DC function is required for tolerance induction...
  80. ncbi CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    Thomas R Malek
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101, USA
    Immunity 17:167-78. 2002
    ..These observations indicate that the essential function of the IL-2/IL-2R system primarily lies at the level of the production of CD4(+)CD25(+) regulatory T cells...
  81. ncbi Inducible IL-2 production by dendritic cells revealed by global gene expression analysis
    F Granucci
    University of Milano-Bicocca, Department of Biotechnology and Bioscience, Piazza della Scienza 2, Milan, Italy
    Nat Immunol 2:882-8. 2001
    ..In contrast, macrophages did not produce IL-2 upon bacterial stimulation. Thus, IL-2 is an additional key cytokine that confers unique T cell stimulatory capacity to DCs...
  82. ncbi Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract
    Kathryn B Renegar
    Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 173:1978-86. 2004
    ....
  83. pmc Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection
    Stephen P Saville
    Division of Infectious Diseases, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Eukaryot Cell 2:1053-60. 2003
    ..albicans pathogenesis. This engineered strain should provide a useful tool in unraveling the individual contributions of the yeast and filamentous forms at various stages of the infectious process...
  84. ncbi Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
    Ana Pamplona
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    Nat Med 13:703-10. 2007
    ..These effects were mediated by the binding of CO to hemoglobin, preventing hemoglobin oxidation and the generation of free heme, a molecule that triggers ECM pathogenesis...
  85. pmc Aquatic insects as a vector for Mycobacterium ulcerans
    Laurent Marsollier
    Laboratoire de bactériologie virologie hygiène, CHU, 49033 Angers, France
    Appl Environ Microbiol 68:4623-8. 2002
    ..ulcerans from wild aquatic insects collected from a zone in the Daloa region of Ivory Coast where Buruli ulcer is endemic. Taken together, these results point to aquatic insects as a possible vector of M. ulcerans...
  86. pmc Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 204:3133-46. 2007
    ..We propose that this is an important and previously unappreciated element of immunosurveillance that needs to be taken into account in the design of novel vaccine strategies...
  87. ncbi Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    R A Clynes
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Ave, New York, New York 10021, USA
    Nat Med 6:443-6. 2000
    ....
  88. pmc Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    Wanjun Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1875-86. 2003
    ..Finally, in a murine asthma model, coadministration of these TGF-beta-induced suppressor T cells prevented house dust mite-induced allergic pathogenesis in lungs...
  89. ncbi Reduction of myeloid-derived suppressor cells and induction of M1 macrophages facilitate the rejection of established metastatic disease
    Pratima Sinha
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    J Immunol 174:636-45. 2005
    ..These mechanisms occur in STAT6(-/-) mice because STAT6 deficiency prevents signaling through the type 2 IL-4Ralpha, thereby blocking the production of arginase and promoting the synthesis of NO...
  90. pmc Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21231, USA
    J Exp Med 203:2691-702. 2006
    ..In light of the recent data that enzymes mediating MDSC-dependent immunosuppression in mice are active also in humans, these findings demonstrate a potentially novel use of PDE5 inhibitors as adjuncts to tumor-specific immune therapy...
  91. ncbi The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
    W Jiang
    Laboratory of Molecular Immunology, Rockefeller University, New York, New York 10021, USA
    Nature 375:151-5. 1995
    ..Thus DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment...
  92. ncbi Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
    Katharina Aschenbrenner
    Research Institute of Molecular Pathology, 1030 Vienna, Austria
    Nat Immunol 8:351-8. 2007
    ..Thus, 'routing' of mTEC-derived self antigens may determine whether specific thymocytes are deleted or enter the regulatory T cell lineage...
  93. ncbi Inducing and expanding regulatory T cell populations by foreign antigen
    Karsten Kretschmer
    Department of Pathology, Harvard Medical School, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1219-27. 2005
    ..The extrathymic generation and proliferation of regulatory T cells may contribute to self-tolerance as well as the poor immunogenicity of tumors and may be exploited clinically to prevent or reverse unwanted immunity...
  94. pmc Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells
    Kamalakannan Velmurugan
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
    PLoS Pathog 3:e110. 2007
    ..tuberculosis and support a direct causal relationship between virulence of pathogenic mycobacteria and their ability to inhibit macrophage apoptosis...
  95. ncbi ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
    A Hutloff
    Molecular Immunology, Robert Koch Institut, Berlin, Germany
    Nature 397:263-6. 1999
    ..Our results indicate that ICOS is another major regulator of the adaptive immune system...
  96. pmc Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow
    Z Hao
    Department of Immunology, Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
    J Exp Med 194:1151-64. 2001
    ..Mice in which RAG-2 was deleted at birth maintained a small population of activated B cells with an increased proportion of marginal zone B cells. Additionally, an increase of the pool of IgM secreting cells and B-1a cells was observed...
  97. pmc Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice
    Masato Hatta
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, Wisconsin, USA
    PLoS Pathog 3:1374-9. 2007
    ....
  98. ncbi MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia
    J Bernhagen
    Picower Institute for Medical Research, Manhasset, New York 11030
    Nature 365:756-9. 1993
    ..We conclude that MIF plays a central role in the toxic response to endotoxaemia and possibly septic shock...
  99. pmc Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells
    Joachim Lehmann
    Experimentelle Rheumatologie, Universitatsklinikum Charite, Humboldt Universitat, c o Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 99:13031-6. 2002
    ..Thus, the integrin alpha(E)beta(7) can be regarded as a novel marker for subsets of highly potent, functionally distinct regulatory T cells specialized for crosstalk with epithelial environments...
  100. pmc Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    D J Berg
    Department of Immunology and Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Clin Invest 98:1010-20. 1996
    ..In 3-mo-old mutants, intestinal lesions were most severe in IL-10-/- 129/SvEv and IL-10-/- BALB/c strains, of intermediate severity in the IL-10-/- 129 x C57BL/6J outbreds, and least severe in the IL-10-/- C57BL/6J strain...
  101. pmc Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
    Robert M Anthony
    Department of Medicine, New Jersey Medical School, 185 S Orange Avenue, Newark, New Jersey 07103, USA
    Nat Med 12:955-60. 2006
    ....

Research Grants73

  1. Identification of Genetic and Epigenetic Alterations in Spondyloarthritis
    Tibor T Glant; Fiscal Year: 2013
    ....
  2. Novel DNA-Launched Attenuated Vaccine for VEE Virus
    PETER M PUSHKO; Fiscal Year: 2012
    ..If successful, this technology can potentially transform the field of live attenuated vaccines for many viral diseases. ..
  3. MAPPING OF ARTHRITIS SUSCEPTIBILITY GENES
    Tibor T Glant; Fiscal Year: 2013
    ..We propose to reduce the size of these regions in the mouse genome, which cannot be done in human population, and select candidate genes that may be involved in arthritis susceptibility and disease severity. ..
  4. Epigenetic downregulation of the antibody response and inhibition of autoimmunity
    Paolo Casali; Fiscal Year: 2013
    ....
  5. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..This will provide a basis for potential further development of BB3 as a therapeutic for emphysema. ..
  6. Apple peel extract inhibits Cr(VI)-induced lung cancer
    Zhuo Zhang; Fiscal Year: 2013
    ..In this aim we will Investigate the protection of apple peel extract against Cr(VI)-induced inflammation, chronic oxidative lung injury, and cell proliferation using female BALB/c mice. ..
  7. Inner Ear Impact of Chronic Middle Ear Inflammation
    DENNIS ROYAL TRUNE; Fiscal Year: 2013
    ..Finally, various treatments will be targeted to these specific phases of inflammation to suppress the immune responses and protect the inner ear from permanent damage. ..
  8. Development of transformed lactobacilli as a microbicide
    Richard B Markham; Fiscal Year: 2010
    ....
  9. Immunoglobulin Activation of Fibroblasts
    Terry J Smith; Fiscal Year: 2012
    ..In this proposal, we identify abnormalities in human immune system that underlie development of TAO, and apply these insights to animal models in which treatments can be developed. ..
  10. Target discovery and immunoassay for diagnosis of invasive aspergillosis
    Thomas R Kozel; Fiscal Year: 2013
    ..abstract_text> ..
  11. Toward suicidal automation of porphyric Leishmania for photodynamic vaccination
    Kwang Poo Chang; Fiscal Year: 2010
    ..The outcome of the study will help us produce a universal carrier to deliver vaccines for preventing and treating infectious and non-infectious diseases. ..
  12. A Mucosal RSV Vaccine
    Kejian Yang; Fiscal Year: 2013
    ....
  13. Endogenous Retroviruses and the Immune Response to Pathogens
    JAQUELIN PAGE DUDLEY; Fiscal Year: 2013
    ..The long-term goal of this proposal is the development of new approaches for treatment of infectious disease. ..
  14. Tissue Kallikrein In Immune Mediated Nephritis
    Quan Zhen Li; Fiscal Year: 2011
    ..We will evaluate if the targeted gene therapy will be able to prevent or cure the kidney disease caused by lupus, using this mouse model. ..
  15. Fliz1 regulation of GATA-3 in breast cancer
    Janice E Knepper; Fiscal Year: 2013
    ..If Fliz1 expression contributes to the loss of GATA-3 expression seen in invasive human breast cancer, a potent therapeutic target is presented which could increase tumor sensitivity to hormone therapy and decrease metastatic potential. ..
  16. Immune and genetic determinants of murine glomerulonephritis
    Elahna Paul; Fiscal Year: 2012
    ..abstract_text> ..
  17. Perinatal exposure to environmental estrogens and asthma pathogenesis
    Terumi Midoro Horiuti; Fiscal Year: 2010
    ..This project will develop a mouse model to investigate the effects of environmental estrogen-like chemicals on the development of asthma in children. ..
  18. The role of Immunoglobulin CDRH3 in Autoimmune Disease
    HARRY WILLIAM SCHROEDER; Fiscal Year: 2012
    ..We predict that the information we glean from our studies will help us learn how to prevent lupus, as well as control humoral responses to pathogens, vaccines, and altered-self antigens. ..
  19. Epigenetic modulation of antidepressant efficacy
    Claudia Schmauss; Fiscal Year: 2013
    ..Positive results from these studies could identify a new biomarker capable of predicting antidepressant treatment response. ..
  20. Chemokines and regulation of T cell responses during infection
    Abhay Satoskar; Fiscal Year: 2009
    ..abstract_text> ..
  21. The Contribution of Chronic Inflammation to Pulmonary Adenocarcinoma
    MICHAEL LAWRENCE DOUGAN; Fiscal Year: 2010
    ....
  22. Mechanisms underlying T helper suppression by regulatory T cells
    AYANA JORDAN; Fiscal Year: 2009
    ..By studying the behavior of this cell type (Treg), the causes of different human diseases can be better understood and new therapies developed. ..
  23. Mechanisms of particulate chromium lung carcinogenesis
    SUSAN M CERYAK; Fiscal Year: 2011
    ....
  24. Precocious immune senescence induced by pre- & postnatal atrazine exposure
    John B Barnett; Fiscal Year: 2010
    ....
  25. Interplay of Innate and Adaptive Immunity in Lupus Pathogenesis
    Michelle L Hermiston; Fiscal Year: 2013
    ....
  26. REGULATION OF NEONATAL IMMUNITY
    Habib Zaghouani; Fiscal Year: 2010
    ..Understanding the function of the neonatal immune system could facilitate development of strategies to balance Th1 and Th2 responses and overcome the susceptibility of the neonate to allergic reactions and microbial infections. ..
  27. Immune Recognition of Citrullinated Cartilage PG Aggrecan in Autoimmune Arthritis
    Katalin Mikecz; Fiscal Year: 2013
    ..The results of our studies should provide clinically relevant insights into the role of citrullinated PG in the pathogenesis of ACPA+ RA. ..
  28. Mouse Model of Age-Associated Monoclonal Gammopathy
    Peter Leif Bergsagel; Fiscal Year: 2013
    ..This project will use genetically engineered mice to dissect the mechanisms of disease susceptibility, biology and progression, performing studies that cannot be done in man, but with direct relevance to the human disease. ..
  29. Lapatinib and Obatoclax combination therapy
    Paul Dent; Fiscal Year: 2013
    ..As Lapatinib is already FDA approved, the successful completion of the studies proposed in this application would rapidly facilitate phase I translation of the drug combination in patients with recurrent breast cancer. ..
  30. Isolation, Identification and Characterization of a Toxin Causing Biliary Atresia
    Rebecca G Wells; Fiscal Year: 2013
    ..glomulifera toxins~ and 3. To identify and characterize damage pathways induced by D. glomulifera toxins in mammalian models. ..
  31. Activation and regulation of autoreactive B cells in health and disease
    Mark J Shlomchik; Fiscal Year: 2012
    ..Since B cells are absolutely required for these diseases, and depleting them can induce remission in humans, this work is at the crux of understanding how autoimmune diseases like lupus occur and how to better treat them. ..
  32. Targeting SYK Tyrosine Kinase to Overcome Radiation Resistance in ALL
    Fatih M Uckun; Fiscal Year: 2013
    ..The successful completion of this research project may provide the foundation for therapeutic innovation against childhood leukemia. ..
  33. Interleukin-2 and autoimmune disease
    Abul K Abbas; Fiscal Year: 2012
    ..These studies will shed light on the mechanisms of immune regulation and tolerance, and may help to optimize protocols for the therapeutic uses of IL-2 and its antagonists. ..
  34. Targeting Leukemia Stem Cells with Dietary Selenium
    KUMBLE SANDEEP PRABHU; Fiscal Year: 2013
    ....
  35. Scanning Chlamydia proteome for vaccine antigens
    Luis M de la Maza; Fiscal Year: 2010
    ..An efficacious vaccine against C. trachomatis will have a tremendous health and economic impact throughout the world. ..
  36. Chemopreventition and treatment of non-melanoma skin cancer by targeting MIF
    Abhay R Satoskar; Fiscal Year: 2013
    ..These data will lay the foundation for a latter RO1 application to develop better and safer MIF antagonists as novel drugs for prevention and treatment of skin cancer. ..
  37. Mouse models of age-associated monoclonal gammopathy
    PETER BERGSAGEL; Fiscal Year: 2009
    ..The results will have important implications for the prognosis, prevention and treatment of individuals with MGUS, patients with MM, and cancer patients generally. ..
  38. Aging, Microglial Dysregulation and Depression
    Jonathan P Godbout; Fiscal Year: 2013
    ..Thus, microglial hyperactivity with prolonged IDO activation may underlie inflammatory-related depression in the elderly. ..
  39. T Cell Tolerance in Neonates
    Habib Zaghouani; Fiscal Year: 2010
    ..Understanding the function of the neonatal immune system could facilitate development of strategies to balance Th1 and Th2 responses and overcome the susceptibility of the neonate to allergic reactions and microbial infections. ..
  40. Development of a Rationally Attenuated Live Vaccine for Francisella tularensis
    Stefanie N Vogel; Fiscal Year: 2013
    ..At the completion of this study, we expect to have developed a rationally attenuated vaccine candidate that will protect against multiple Ft Type A and Type B Francisella strains. ..
  41. HCMV Vaccine produced from BAC-MVA that Blocks Epithelial and Fibroblast Entry
    Don J Diamond; Fiscal Year: 2013
    ..The anticipated result of these studies will be an HCMV-based subunit vaccine ready for clinical development. ..
  42. Characterization of A Novel Regulatory Protein in M. tuberculosis
    Adel M Talaat; Fiscal Year: 2012
    ..tb virulence. PUBLIC HEALTH RELEVANCE: This project focuses on better understanding of the molecular basis of tuberculosis, a worldwide health problem to mankind. This project is highly relative to the mission of the NIH/NIAID. ..
  43. Virus-Like Particle Vaccine for SARS-CoV
    RAPHAEL PAUL VISCIDI; Fiscal Year: 2010
    ..The successful implementation of the proposed studies would provide a stepping-stone toward future clinical trials with a VLP-based SARS-CoV vaccine. ..
  44. Brucella epitope recognition by CD8+T cells
    Gary A Splitter; Fiscal Year: 2013
    ..Our findings will provide future opportunities to enhance development and persistence of functional CD8+T cells leading to improved bacterial clearance and designing vaccines that can potentate CD8+T memory cells. ..
  45. Studies on the role of IL-23p19/IL-17 cascade in the pathogenesis of acute GVHD
    JOHN SECORD THOMPSON; Fiscal Year: 2012
    ..The proposed studies are to investigate a new approach to minimize GVHD ..
  46. Molecular Approaches to Reversing Corneal Goblet Cell Hyperplasia
    Mary Ann Stepp; Fiscal Year: 2013
    ..Data from these studies will improve our ability to target treatments that aim to reduce the proliferation of goblet cells n the ocular surface. ..
  47. Memory CD8 T cell immunity to Plasmodium liver stage infec
    John T Harty; Fiscal Year: 2013
    ..Addressing this knowledge gap would aid in the rational design of malaria vaccines and is the goal of this proposal. ..
  48. The role of adenosine in the pathogenesis of influenza
    IAN CHRISTOPHER DAVIS; Fiscal Year: 2013
    ....
  49. CysLT and P2Y Receptors in Lung Inflammation
    Joshua A Boyce; Fiscal Year: 2013
    ....
  50. Pubertal high fat diet: effects on inflammation, mammary development and cancer
    Sandra Z Haslam; Fiscal Year: 2013
    ..With their community breast cancer advocacy partner, Michigan Breast Cancer Coalition, the investigators will translate and communicate their research findings to the concerned public. ..
  51. Babesiosis as a model of age-related immunosenescence
    Henry H Wortis; Fiscal Year: 2012
    ..Because there is great similarity between the genes of mice and humans we believe our discoveries in mice will aid work to understand the genetic basis of age-related susceptibility to infection in humans. ..
  52. Altered Arachidonic Acid Balance and Colon Cancer
    DANIEL WILLIAM ROSENBERG; Fiscal Year: 2010
    ..Our goal would be to improve targeting of individuals most likely to respond to chemopreventive agents that impact the AA metabolic pathway. ..
  53. BIOMEDICAL APPLICATIONS OF EXPANDED PORPHYRINS
    Alan B Watts; Fiscal Year: 2013
    ..The net result of this effort will be one or more agents in advanced preclinical testing that addresses the all- important problem of platinum drug resistance. ..
  54. Novel anti-viral agents to treat influenza
    Dipanwita Basu; Fiscal Year: 2013
    ..Aim 4 will culminate with in vivo testing in BALB/c mice, including MTD, PK and efficacy studies. ..
  55. (PQA2) MAMMALIAN REGENERATION, HIGH FAT DIETS, AND BREAST CANCER: A COMMON LINK?
    ELLEN PURE apos PURE'; Fiscal Year: 2013
    ..Working together as a team, the combined expertise of Drs. Heber-Katz and Pur[unreadable] render the important but complex goals of this project eminently feasible. ..
  56. C3 chemical conjugation to improve the anti-cocaine immune response
    Paul Wentworth; Fiscal Year: 2012
    ..This proposal harnesses the power of the innate immune system by chemical synthesis of small molecule vaccines coupled to complement protein C3 to generate novel small molecule vaccines. ..
  57. Genetic Factors Controlling Effector Function of TGF-beta in COPD and Fibrosis
    Chun Geun Lee; Fiscal Year: 2011
    ..AIM #4. Define the genes that determine whether TGF-b1 induceds a predominantly fibrotic versus emphysematous response in C57BL/6 and Balb/c mice. ..
  58. JAK2_STAT3 as a therapeutic target and marker of graft-versus-host disease
    Brian C Betts; Fiscal Year: 2013
    ..The informative data provided by aim 3, if positive, will be validated in a larger patient population to determine f the STAT3, STAT5, and ERK1/2 phosphorylation predict the risk of acute GvHD. ..
  59. SRP RNA level as a determinant of leishmanial parasitism of macrophages
    Gautam Chaudhuri; Fiscal Year: 2009
    ..Understanding host-parasite interaction mechanisms interplayed between macrophages and Leishmania in molecular details will help us in developing combat measures against this often deadly human pathogen. ..
  60. Sten Cell Gene Therapy of Breast Cancer
    ANDRE MICHAEL LIEBER; Fiscal Year: 2013
    ..Key findings will be validated in a second breast cancer model that involves 4T1 cells and BALB/c mice. ..
  61. CD8aa+ Cells and Ovarian Functions
    YAHUAN LOU; Fiscal Year: 2010
    ....
  62. Nonpeptide macrocyclic histone deacetylase (HDAC) inhibitors for targeted lung ca
    ADEGBOYEGA OYELERE; Fiscal Year: 2013
    ..Our proposed approach is expected to lead to chemotherapeutic agents with superior therapeutic indices and will significantly impact patient survival prognosis and positively contribute to human health management. ..
  63. Ocular Lymphangiogenesis
    DANIEL J CARR; Fiscal Year: 2010
    ....
  64. MECHANISM OF TRH EFFECTS IN FETAL LUNG DEVELOPMENT
    UDAY DEVASKAR; Fiscal Year: 1999
    ....
  65. Fatty Acid Synthase Inhibitors: Ovarian Cancer Therapy
    ALBERT OWENS; Fiscal Year: 2007
    ..abstract_text> ..
  66. Immunoglobulin CDR-H3 and neutralizing antibodies to HIV
    Harry Schroeder; Fiscal Year: 2009
    ....
  67. Monoclonal Antibodies Against T-Regulatory Cells
    Alan Epstein; Fiscal Year: 2005
    ..Along with LEC/NHS76, this new antibody/drug conjugate should be applicable to use in humans and may provide clinicians with a vital weapon in our relentless effort to treat cancer. ..
  68. Novel Linear Peptide Universal Malaria Vaccines
    Alberto Moreno; Fiscal Year: 2005
    ..falciparum, respectively. These approaches will provide strong data to evaluate the LPC approach as a ways forward for clinical trials, whether used singly or in combination with other malaria vaccine platforms. ..
  69. Immunity to versican and ankylosing spondylitis
    Yiping Zhang; Fiscal Year: 2007
    ..We also intend to identify the role of HLA-B27 in the pathogenesis of the VGI/model using human HLA-B*2705 transgenic animals. ..
  70. Chitosan IFNgamma-pDNA Nanosphere Therapy and Immunopathology of Allergic Asthma
    Shyam Mohapatra; Fiscal Year: 2006
    ..It is anticipated that the results of these studies will contribute significantly to our knowledge of asthma and CIN therapy may provide a major breakthrough in management of asthma. ..
  71. CHRONOBIOLOGICAL INVESTIGATION OF TNF AND IL-2
    William Hrushesky; Fiscal Year: 1992
    ....
  72. Development of a Malaria DNA Vaccine with Enchanced Immunogenicity
    Richard Markham; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: This project is designed to develop a vaccine for malaria. Should this approach be successful, this vaccine could save the more than 1 million deaths that occur annually as a result of this infection. ..
  73. Mechanisms of experimental drug-induced hepatitis
    Dolores Njoku; Fiscal Year: 2007
    ..3) To confirm antigenic spread in TFA-CYP2E1-immunized mice using spleenocyte proliferation assays stimulated with ERp58 and ASGPR and analyzed as in Specific Aim 2. [unreadable] [unreadable] [unreadable] [unreadable]..