- Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
Genetics 172:1783-97. 2006
..However, even with a very large panel of RILs, mapping resolution may not be sufficient to identify single genes unambiguously. Our results are generally applicable to the design of RILs in other species...
- Methodology for the measurement of mucociliary function in the mouse by scintigraphy
W M Foster
Department of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Appl Physiol (1985) 90:1111-7. 2001
- Tumour blood flow changes induced by application of electric pulses
Department of Tumour Biology, Institute of Oncology, Ljubljana, Slovenia
Eur J Cancer 35:672-7. 1999
..Tumour blood flow reduction by electric pulses could have potential in exploiting modalities mediated by tumour hypoxia, e.g. activation of bioreductive agents...
- Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Infect Immun 71:4831-41. 2003
..Our studies highlight a role for sexual recombination in the evolution of a human fungal pathogen and provide a robust genetic platform to establish the molecular determinants of virulence...
- Butylated hydroxytoluene (BHT) induction of pulmonary inflammation: a role in tumor promotion
A K Bauer
Department of Pharmacology, University of Colorado Health Sciences Center, C238, 4200 East Ninth Avenue, Denver, CO 80262, USA
Exp Lung Res 27:197-216. 2001
..Inflammatory mediators may provide targets for early diagnosis and chemoprevention...
- Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice
Department of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6
Proc Natl Acad Sci U S A 98:10793-8. 2001
..Our findings provide an entry point for parallel association studies in humans between the syntenic 4q21-4q25 region and susceptibility to disease in endemic areas of malaria...
- The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila
Department of Biochemistry, McGill University, Montreal, Canada
J Immunol 164:1470-7. 2000
- Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements
Terry Fox Laboratory, BC Cancer Research Centre, Vancouver, British Columbia, Canada
PLoS Genet 4:e1000007. 2008
..These extreme levels of polymorphism suggest that ERV insertions play a significant role in genetic drift of mouse lines...
- Reduced tumor oxygenation by treatment with vinblastine
Department of Tumor Biology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
Cancer Res 61:4266-71. 2001
- Early recruitment of neutrophils determines subsequent T1/T2 host responses in a murine model of Legionella pneumophila pneumonia
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 166:3355-61. 2001
..pneumophila infection, not via direct killing but more immunomodulatory effects. Our results suggest that the early recruitment of neutrophils may contribute to T1 polarization in a murine model of L. pneumophila pneumonia...
- IL-12 is required for antibody-mediated protective immunity against blood-stage Plasmodium chabaudi AS malaria infection in mice
Center for the Study of Host Resistance, Montreal General Hospital Research Institute, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
J Immunol 168:1348-55. 2002
- Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application
Boehringer Ingelheim Austria, Dr Boehringer Gasse 5-11, A-1121 Vienna, Austria
Gene Ther 8:28-40. 2001
..In the tumor, DNA was associated mainly with tumor cells and frequently found near structures which resemble primitive blood vessels...
- The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells
Jennifer L Brogdon
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 168:3825-32. 2002
..These data provide a model for how the strength of TCR signaling can influence the generation of Th1 and Th2 cells...
- A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes
Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
Science 295:679-82. 2002
..pneumophila. Translocation of RalF protein through the phagosomal membrane is a dot/icm-dependent process. Thus, RalF is a substrate of the Dot/Icm secretion apparatus...
- A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death
Rita K Laguna
Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 103:18745-50. 2006
..Defective intracellular growth of the sdhA(-) mutant could be partially suppressed by the action of caspase inhibitors, but caspase-independent cell death pathways eventually aborted replication of the mutant...
- Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatin
Institute of Oncology, Ljubljana, Slovenia
Br J Cancer 79:1386-91. 1999
..In addition, besides electroporation, immune system and tumour blood flow changes could be involved in the observed anti-tumour effectiveness of electrochemotherapy...
- Monokine induced by IFN-gamma is a dominant factor directing T cells into murine cardiac allografts during acute rejection
Urological Institute and Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
J Immunol 167:3494-504. 2001
..Although Mig antagonism delays acute heart allograft rejection, the results also suggest that the alloimmune response circumvents Mig antagonism through alternative mechanisms...
- Persistence of physiological self antigen is required for the regulation of self tolerance
K M Garza
Departments of Microbiology and Pathology, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 164:3982-9. 2000
..In contrast, exposure to endogenous ovarian Ag confined to the neonatal period is insufficient for the induction and maintenance of tolerance to ZP3...
- Genetic control of blood parasitaemia in mouse malaria maps to chromosome 8
Nat Genet 17:382-3. 1997
- A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth
Vicki P Losick
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Ave, Boston, MA 02111, USA
Infect Immun 77:196-204. 2009
..Therefore, one of these mutations may be critical for restriction of L. pneumophila intracellular growth, and this parallels results found with human NLR variants with defects in the innate immune response...
- Strong position-dependent effects of sequence mismatches on signal ratios measured using long oligonucleotide microarrays
Biosciences Building, School of Biological Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK
BMC Genomics 9:317. 2008
..Sequence mismatches between probe and target strands are known to affect the stability of the probe-target duplex, and hence the strength of the observed signals from microarrays...
- High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis
J D Growney
Harvard Medical School Department of Genetics, Boston, Massachusetts 02115, USA
Genome Res 10:1158-71. 2000
..Our genetic map suggests the presence of two hotspots of recombination within the Naip array, indicating that the 3' portion of Naip may be involved in the genomic instability at this locus...
- Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-a
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave 16 825, Cambridge, MA 02139, USA
Infect Immun 76:1866-76. 2008
..The use of AB6F1 and B6AF1 mice, as well as genetically engineered mice, on a C57BL/6 background will allow studies investigating the role of chronic microbial hepatitis and steatohepatitis in the pathogenesis of liver cancer...
- Behavioural analysis of four mouse strains in an anxiety test battery
M M van Gaalen
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804, Munich, Germany
Behav Brain Res 115:95-106. 2000
..In addition, the data indicate that different anxiety paradigms tax different aspects of anxiety, suggesting that a battery of different tests should be used in studies of anxiety-related behaviour...
- Pyruvate kinase deficiency in mice protects against malaria
Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada
Nat Genet 35:357-62. 2003
..These results suggest that pyruvate kinase deficiency may similarly protect humans against malaria...
- Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype
Jessica J Nadler
Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill 27599 7264, USA
Genetics 174:1229-36. 2006
..Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression...
- Endogenous oocyte antigens are required for rapid induction and progression of autoimmune ovarian disease following day-3 thymectomy
Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 166:4363-9. 2001
..Similar results were obtained in mice OX at 4 wk. Thus endogenous tissue Ag are critical in autoimmune disease induction and progression that occur spontaneously upon regulatory T cell depletion...
- Cholangiohepatitis and inflammatory bowel disease induced by a novel urease-negative Helicobacter species in A/J and Tac:ICR:HascidfRF mice
N H Shomer
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
Exp Biol Med (Maywood) 226:420-8. 2001
..These results provide a new model of IBD and cholangio-hepatitis associated with a specific urease-negative, novel H. species...
- Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death
A B Molofsky
Department of Microbiology and Immunology, University of Michigan Medical School, 6734 Medical Sciences Building II, Ann Arbor, MI 48109 0620, USA
Infect Immun 73:5720-34. 2005
..Thus, the flagellar regulon equips the aquatic pathogen L. pneumophila to coordinate motility with multiple traits vital to virulence...
- In vivo tumor transfection mediated by polyplexes based on biodegradable poly(DMAEA)-phosphazene
Holger K de Wolf
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, The Netherlands
J Control Release 109:275-87. 2005
..The observed preferential tumor gene expression mediated by the p(DMAEA)-ppz polyplexes enables the application of this polymer to deliver therapeutic genes to tumors...
- SpoT governs Legionella pneumophila differentiation in host macrophages
Zachary D Dalebroux
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA
Mol Microbiol 71:640-58. 2009
..Thus, L. pneumophila requires SpoT to monitor FAB and to alternate between replication and transmission in macrophages...
- Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model
Department of Biochemistry, McGill University, Montreal, Quebec, Canada
Genes Immun 5:168-75. 2004
..chabaudi infection. The possible molecular basis of the Pklr protective effect is discussed and is under current investigation in these two strains...
- Spectrum of Legionella species whose intracellular multiplication in murine macrophages is genetically controlled by Lgn1
Department of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Infect Immun 64:1842-5. 1996
..pneumophila strains tested was controlled by Lgn1. However, the intracellular growth of five Legionella species other than L. pneumophila was not under Lgn1's control...
- CD40 ligand in pathogenesis of autoimmune ovarian disease of day 3-thymectomized mice: implication for CD40 ligand antibody therapy
Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 170:1667-74. 2003
- Maternal autoantibody triggers de novo T cell-mediated neonatal autoimmune disease
Yulius Y Setiady
Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 170:4656-64. 2003
..Therefore, a new mechanism of neonatal autoimmunity is presented in which epitope-specific autoantibody stimulates de novo autoimmune pathogenic CD4(+) T cell response...
- Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice
Nadine De Albuquerque
Toronto General Hospital, 585 University Ave, NCSB 11 1236, Toronto, Ontario M5G 2N2, Canada
J Virol 80:10382-94. 2006
..This study describes a potentially useful small animal model of human SARS, defines its pathogenesis, and suggests treatment strategies...
- Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells
Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Japan
Immunity 23:191-202. 2005
..These findings indicate a novel mechanism of development of chronic allergic inflammation that is induced by basophils through the interaction of antigen, IgE, and FcRI...
- Nonobese diabetic mice display elevated levels of class II-associated invariant chain peptide associated with I-Ag7 on the cell surface
Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Immunol 166:4490-7. 2001
..These results indicated that an intrinsic property of I-A(g7) would affect both the quantity and the repertoire of self-peptides presented during thymic selection...
- Plasminogen alleles influence susceptibility to invasive aspergillosis
Aimee K Zaas
Duke University Medical Center, Durham, North Carolina, United States of America
PLoS Genet 4:e1000101. 2008
..Furthermore, we demonstrated that plasminogen directly binds to Aspergillus fumigatus. We propose that genetic variation within the plasminogen pathway influences the pathogenesis of this invasive fungal infection...
- Down-regulation of the SWI/SNF chromatin remodeling activity by TCR signaling is required for proper thymocyte maturation
Kyoo Y Lee
Department of Biological Sciences, Institute of Molecular Biology and Genetics, and Research Center for Functional Cellulomics, Seoul National University, Seoul, Korea
J Immunol 178:7088-96. 2007
..Our results state, for the first time, that the chromatin remodeling activity needs to be finely controlled for proper thymocyte selection and maturation processes...
- Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice
Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York 12201 0509, USA
Cancer Res 67:7825-32. 2007
- Contribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi
Luiz Roberto Sardinha
Departamento de Imunologia, ICB, Av Prof Lineu Prestes, 1730, Universidade de Sao Paulo, Sao Paulo, SP CEP 05508 000, Brazil
Infect Immun 74:2031-42. 2006
- MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection
ETH Zurich, Institute for Microbiology, 8093 Zurich, Switzerland
J Immunol 176:6162-71. 2006
- The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains
Kevin Y T Thia
Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, A Beckett Street, East Melbourne 8006, Australia
Tissue Antigens 70:198-204. 2007
..Unlike the protease, the extended granzyme B recognition and cleavage site in Bid, a key pro-apoptotic substrate, was invariant...
- Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1
T J D'Orazio
Graduate Program in Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
J Immunol 166:26-32. 2001
- Both gamma delta T cells and NK cells inhibit the engraftment of xenogeneic rat bone marrow cells and the induction of xenograft tolerance in mice
Bone Marrow Transplantation Section, Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
J Immunol 166:1398-404. 2001
..2 and anti-NK1.1 mAbs in TCRdelta(-/-) mice. Therefore, in addition to CD4 and CD8 T cells, gammadelta T cells and NK cells play a role in resisting engraftment of rat marrow and the induction of xenograft tolerance in mice...
- The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
J Immunol 175:2340-8. 2005
..These results indicated that the ICOS/B7RP-1 interaction plays an essential role in the development of CXCR5+ T(FH) cells in vivo...
- Iodine and IFN-gamma synergistically enhance intercellular adhesion molecule 1 expression on NOD.H2h4 mouse thyrocytes
Rajni B Sharma
Department of Pathology, School of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
J Immunol 174:7740-5. 2005
..These findings suggest that iodine and IFN-gamma cooperate to promote thyroidal expression of ICAM-1 in this mouse model of thyroiditis, highlighting the complex interplay present in the pathogenesis of Hashimoto's thyroiditis...
- H-41, a new minor histocompatibility locus. I. Histogenetic analysis
J Immunol 133:2950-4. 1984
..The B10.STA10 anti-B10.STA12 CTL exhibit, in addition, a cross-reactivity with B10.SAA48 cells that may be directed at one of the alloantigens controlled by the H-2 haplotype of this strain...
- Mechanisms of enhanced macrophage-mediated prostaglandin E2 production and its suppressive role in Th1 activation in Th2-dominant BALB/c mice
Department of Immunology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
J Immunol 170:757-64. 2003
- Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence
Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, 10314, USA
Neuroscience 115:463-9. 2002
..The data also demonstrate that the differential genetic liability to morphine physical dependence begins with, and is predicted by, the first morphine exposure...
- Costimulation of multiple NK cell activation receptors by NKG2D
Emily L Ho
Division of Rheumatology Howard Hughes Medical Institute, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110, USA
J Immunol 169:3667-75. 2002
..1, or Ly-49D) and NKG2D leads to augmentation of cytokine release compared with stimulation through the activation receptor alone. These results demonstrate that NKG2D has the ability to costimulate multiple NK activation receptors...
- Mouse strain variation in maximal electroshock seizure threshold
Thomas N Ferraro
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
Brain Res 936:82-6. 2002
..We conclude that MEST represents a useful tool for dissecting the multifactorial nature of seizure sensitivity in mice...
- Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Poli gene as a candidate for Par2
Gang Hong Lee
Department of Pathology, Toramomon Hospital and Okinaka Memorial Institute for Medical Research 2 2 2 Toranomon, Minatoku, Tokyo 105 8470, Japan
Oncogene 22:2374-82. 2003
..Consequently, the Poli is an intriguing Par2 candidate clearly deserving further evaluation...
- The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics
Sonya G Wilson
Department of Psychology and Program in Neuroscience, University of Illinois at Urbana Champaign, Champaign, Illinois, USA
J Pharmacol Exp Ther 304:547-59. 2003
..However, the genes in question may affect antinociception indirectly, via a primary action on baseline nociceptive sensitivity...
- Mapping blood pressure loci in (A/J x B6)F2 mice
David D L Woo
David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Physiol Genomics 15:236-42. 2003
..Defining the molecular differences between the A/J and the B6 alleles at these novel loci with major influences on the BP phenotype will contribute to our understanding of the complex genetics of BP control...
- Regulation of CD103 expression by CD8+ T cells responding to renal allografts
Department of Surgery, University of Maryland Medical School, 10 South Pine Street, Baltimore, MD 21201, USA
J Immunol 172:214-21. 2004
..These data support a model in which TGF-beta activity present locally at the graft site plays a critical role in regulating CD103 expression, and hence the epitheliotropism, of CD8 effector populations that infiltrate renal allografts...
- Fine chromosomal localization of the mouse Par2 gene that confers resistance against urethane-induction of pulmonary adenomas
G H Lee
Department of Pathology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo 105 8470, Japan
Oncogene 20:3979-85. 2001
..The map information obtained in this study should enable subsequent positional cloning of the Par2 gene...
- Strain distribution pattern of susceptibility to immune-mediated nephritis
Simmons Arthritis Research Center, Division of Rheumatology, Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Immunol 172:5047-55. 2004
..Detailed studies to dissect out the immunological and genetic basis of renal disease in these three strains are clearly warranted...
- Alternative splicing of the K-ras gene in mouse tissues and cell lines
Medical College of Ohio, Toledo, Ohio, USA
Exp Lung Res 27:255-67. 2001
- Definition of a new T lymphocyte cell surface antigen, Ly 11.2
J Immunol 125:2713-8. 1980
..Although the locus coding for this antigen appears to be closely linked to the minor histocompatibility locus H-30 and to the locus coding for Ly 6.2, a chromosome assignment has not yet been made for my of these loci...
- CTL and serologically defined antigens of B2m,H-3 region
M E Kurtz
J Immunol 135:2847-52. 1985
..These loci have been separated by recombination from H-42 in the production of the congenic strain B10.FS-a. A gene order of B2m, H-3, H-42 is suggested...
- Genetics of resistance to infection with Salmonella typhimurium in mice
J Infect Dis 133:72-8. 1976
..However, as previously demonstrated in the parent strains, resistance in the hybrids was related to the ability to produce a good delayed-type hypersensitivity reaction to an extract of S. typhimurium...
- Cellular mechanisms of genetically controlled host resistance to Mycobacterium bovis (BCG)
J Immunol 131:1966-72. 1983
- Linkage of a 7S RNA sequence and kappa light chain genes in the mouse
B A Taylor
Immunogenetics 22:471-81. 1985
..The Rn7s-6 variant is a plus/minus variant; no sequence allelic to Rn7s-6 is found in inbred strains that share the Ly-3a-Igk-Ef1a haplotype...
- Control of mouse hepatitis virus replication in macrophages by a recessive gene on chromosome 7
M S Smith
J Immunol 133:428-32. 1984
..We have identified and mapped a new locus that imparts resistance to productive infection of mouse hepatitis virus MHV(A59) in cultured macrophages. This locus maps 41.5 centimorgans from the albino locus on chromosome 7...
- The location of the C3 and GLO (glyoxalase 1) loci of the IXth linkage group in mice
J Immunol 122:2584-9. 1979
- Restriction fragment analysis of V preB and lambda 5 within the genus Mus
L A D'Hoostelaere
Basel Institute for Immunology, Switzerland
Eur J Immunol 19:37-42. 1989
..These results suggest that V preB1, V preB2 and lambda 5 have been present for over 12 million years...
- A restriction fragment length polymorphism at murine Glud locus co-segregates with Rib-1, Es-10, and Tcra on chromosome 14
Laboratory of Genetics, NCI, Bethesda, MD 20892
Nucleic Acids Res 17:2881. 1989
- Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors
M L Mucenski
NCI Frederick Cancer Research Facility, BRI Basic Research Program, Maryland 21701
Oncogene Res 2:219-33. 1988
..These results suggest that Evi-1 represents a new locus involved in myeloid disease...
- Genetic linkage of resistance to Listeria monocytogenes with macrophage inflammatory responses
M M Stevenson
J Immunol 127:402-7. 1981
- Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice
J Immunol 127:2417-21. 1981
..The product of the Bcg gene was found to influence the early phase of host response resulting in the genetic advantage of the resistant host being demonstrable as early as 24 hr after infection...
- Studies on natural killer (NK) cells. I. NK cell specific antibodies in CE anti-CBA serum
R C Burton
J Immunol 126:1985-9. 1981
..2, and the corresponding antibodies as anti-NK-1.2. However, the possibility that CE anti-CBA serum detects a new system of NK-specific antigen has not been excluded...
- Cell-mediated cytotoxicity to non-MHC alloantigens on mouse epidermal cells. I. H-2 restricted reactions among strains sharing the H-2k haplotype
J Immunol 126:1747-53. 1981
- Evidence for a new lymphocyte-stimulating determinant (Lsd) detected by alloreactive T cell lines
Eur J Immunol 13:24-30. 1983
..BR anti-C57BL/10). The third clone (BD7, C57BL/6 anti-CBA/J) was probably originally directed against Lsd. So far, Lsd is only characterized by stimulation of T cell proliferation, and its physiological function is not yet known...
- NK-2.1: an NK-associated antigen detected with NZB anti-BALB/c serum
S B Pollack
J Immunol 129:2277-81. 1982
- Ly 9, an alloantigenic marker of lymphocyte differentiation
B J Mathieson
J Immunol 125:2127-36. 1980
..Cytotoxic elimination experiments confirm that Ly 9 is expressed on at least 2 different T cell functional subsets and B cells...
- Molecular heterogeneity in the Major Urinary Proteins of the house mouse Mus musculus
D H Robertson
Department of Biochemistry and Applied Molecular Biology, UMIST, Manchester, U K
Biochem J 316:265-72. 1996
..In the two strains there are at least 13 different MUPs, either observed or predicted, indicating the heterogeneity of expression of this group of proteins...
- A new lymphocyte cell surface antigen, Ly-22.2, controlled by a locus on chromosome 4 and a second unlinked locus
J Immunol 130:946-50. 1983
..Strain distribution studies show Ly-22.2 is present in all strains examined except B10-derived congenic strains. It is of interest that C57BL/6 and C57BL/10 mice differ in the expression of this antigen...
- Polygenic control of the immune response to F antigen
D M Silver
Immunogenetics 12:237-51. 1981
..Such complex genetic control suggests regulation by a number of independently segregating loci whose function it is to limit the autoimmune response to F antigen...
- Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
M A DeBenedette
Department of Immunology, University of Toronto, Ontario, Canada
J Immunol 163:4833-41. 1999
..These results further substantiate the idea that different immune responses vary in their dependence on costimulation and suggest a role for 4-1BBL in augmenting suboptimal CTL responses in vivo...
- Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice. Relationship between the molecular type of apoA-II and mouse senile amyloidosis
Department of Senescence Biology, Kyoto University, Japan
Biochem J 279:427-33. 1991
..The molecular type of apoA-II may be a factor involved in the development of senile amyloidosis in mice...
- Strain variation of lymphokine production and specific antibody secretion in mice infected with Mycobacterium lepraemurium
Cell Immunol 91:1-11. 1985
..The level of anti-MLM antibodies was found to be higher in C57BL/6, BALB/c and A/J mice than in the other strains tested. Thus no evidence appeared of a direct influence of the Bcg gene on lymphokine production and antibody secretion...
- Transporters associated with antigen processing (TAP)-independent presentation of soluble insulin to alpha/beta T cells by the class Ib gene product, Qa-1(b)
S M Tompkins
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Exp Med 188:961-71. 1998
..Therefore, this class Ib protein may have access to a novel antigen processing pathway that is not available to class Ia molecules...
- The Ig kappa L chain allelic groups among the Ig kappa haplotypes and Ig kappa crossover populations suggest a gene order
L A D'Hoostelaere
Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
J Immunol 141:652-61. 1988
- Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450
D W Nebert
Mol Pharmacol 8:651-66. 1972
- Structural polymorphism of murine complement factor H controlled by a locus located between the Hc and the beta 2M locus on the second chromosome of the mouse
J Immunol 134:2600-6. 1985
..This was shown by phenotyping the Hc locus and H locus with backcross progenies between A/J (one of strain with H.1) and MoA (one of strain with H.2). The recombination frequency between these two loci was 0.17 +/- 0.046...
- Inherited immunoglobulin idiotypes of the mouse
Immunol Rev 34:119-38. 1977
- Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides
C E Grubin
Department of Immunology, University of Washington, Seattle 98195, USA
Immunity 7:197-208. 1997
..In addition, the data suggest that T cell receptor repertoires selected in wild-type mice and in mice displaying limited spectra of self-peptides are distinct...
- An Eco RI restriction length polymorphism at the murine L-myc locus
I Centro di Riferimento Oncologico, Aviano, Italy
Nucleic Acids Res 16:11853. 1988
- The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles
Institut Armand Frappier, Universite du Quebec, Laval, Canada
Int Immunol 9:533-40. 1997
..Together with our and others previous observations, these results identify the NK2.1/Ly-49C antigen as a receptor for MHC class I molecules whose expression is regulated by host MHC genes...
- Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus
D M Gibson
J Immunol 121:1585-90. 1978
..6 map units) to the Ly-2,3 locus on mouse Chromosome 6. The locus controlling normal light chain IF-patterns has been designated Ef1...
- Fen1 mutations result in autoimmunity, chronic inflammation and cancers
Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, California 91010, USA
Nat Med 13:812-9. 2007
- B-lymphocyte Fc receptor-associated non-H-2 antigens are determined by a single polymorphic locus which is linked to the Mls locus
H B Dickles
J Exp Med 146:1678-92. 1977
..The other (Mls locus) determines antigens which are stimulatory in mixed lymphocyte cultures. These observations suggest that there may be a second gene complex which is the analogue of the I region of the H-2 complex...
- Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway
Andrew M Davidoff
Department of Surgery, St Jude Children s Research Hospital, Memphis, TN 38105, USA
Blood 102:480-8. 2003
..These results have significant implications for gene therapy of autosomal and acquired disorders affecting the liver...
- Legionella pneumophila couples fatty acid flux to microbial differentiation and virulence
Rachel L Edwards
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA
Mol Microbiol 71:1190-1204. 2009
..pneumophila swiftly acclimates to stresses encountered in its host or the environment, thereby enhancing its overall fitness...
- The novel CD4+CD25+ regulatory T cell effector molecule fibrinogen-like protein 2 contributes to the outcome of murine fulminant viral hepatitis
Multi Organ Transplant Program, University of Toronto, Toronto, Ontario, Canada
Hepatology 49:387-97. 2009
..Adoptive transfer of wild-type Tregs into resistant fgl2(-/-) mice increased their mortality caused by MHV-3 infection, whereas transfer of peritoneal exudate macrophages had no adverse effect...
- Mast cells express novel functional IL-15 receptor alpha isoforms
Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
J Immunol 170:5045-55. 2003
..Taken together, our data indicate that murine mast cells express novel, fully functional IL-15R alpha isoforms, which can explain the selective regulatory effects of IL-15 on these cells...
- Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction
Gregory S Jack
Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
J Urol 174:2041-5. 2005
..We performed a pilot study to investigate the ability of human adipose derived, multipotent stem cells to be delivered to and survive within bladder and urethral smooth muscle...
- The targeting of anionized polyvinylpyrrolidone to the renal system
Graduate School of Pharmaceutical Sciences, Department of Biopharmaceutics, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
Biomaterials 25:4309-15. 2004
..Thus, these carboxylated and sulfonated PVPs may be useful polymeric carriers for drug delivery to the kidney and bladder, respectively...
- Effects of buspirone on posthypoxic ventilatory behavior in the C57BL/6J and A/J mouse strains
Department of Medicine, Case Western Reserve University, VA Medical Center, Research Service K216, 10701 East Blvd, Cleveland, OH 44106, USA
J Appl Physiol (1985) 105:518-26. 2008
..We conclude that buspirone improves posthypoxic ventilatory irregularities in the B6 mouse through its agonist effects on the 5-HT1A receptor...