inbred a mice

Summary

Top Publications

  1. pmc Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Genetics 172:1783-97. 2006
  2. ncbi Methodology for the measurement of mucociliary function in the mouse by scintigraphy
    W M Foster
    Department of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Appl Physiol (1985) 90:1111-7. 2001
  3. ncbi Tumour blood flow changes induced by application of electric pulses
    G Sersa
    Department of Tumour Biology, Institute of Oncology, Ljubljana, Slovenia
    Eur J Cancer 35:672-7. 1999
  4. pmc Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates
    Kirsten Nielsen
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Immun 71:4831-41. 2003
  5. ncbi Butylated hydroxytoluene (BHT) induction of pulmonary inflammation: a role in tumor promotion
    A K Bauer
    Department of Pharmacology, University of Colorado Health Sciences Center, C238, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Exp Lung Res 27:197-216. 2001
  6. pmc Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice
    A Fortin
    Department of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 98:10793-8. 2001
  7. ncbi The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila
    E Diez
    Department of Biochemistry, McGill University, Montreal, Canada
    J Immunol 164:1470-7. 2000
  8. pmc Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements
    Ying Zhang
    Terry Fox Laboratory, BC Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS Genet 4:e1000007. 2008
  9. ncbi Reduced tumor oxygenation by treatment with vinblastine
    G Sersa
    Department of Tumor Biology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Cancer Res 61:4266-71. 2001
  10. ncbi Early recruitment of neutrophils determines subsequent T1/T2 host responses in a murine model of Legionella pneumophila pneumonia
    K Tateda
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 166:3355-61. 2001

Research Grants

  1. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004
  2. INIA: System Mechanisms in Stress-Alcohol Interactions
    Douglas Matthews; Fiscal Year: 2006
  3. GABAa receptor g[2] knockout: ethanol and spatial memory
    Douglas Matthews; Fiscal Year: 2006
  4. Genetics of Autontibody Diversification
    Umesh Deshmukh; Fiscal Year: 2008
  5. Central Serotonergic Pathways Regulating Energy Balance
    LORA HEISLER; Fiscal Year: 2007
  6. MOLECULAR BIOLOGY AND PATHOGENESIS OF MOUSE ADENOVIRUS
    KATHERINE SPINDLER; Fiscal Year: 2007
  7. Hostility, Race, and Glucose Metabolism
    Richard Surwit; Fiscal Year: 2006
  8. ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICE
    LINDA TOTH; Fiscal Year: 2006
  9. Autoimmune Oophoritis: Consequences of Gamete Vaccines
    Kenneth Tung; Fiscal Year: 2006
  10. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005

Detail Information

Publications204 found, 100 shown here

  1. pmc Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom
    Genetics 172:1783-97. 2006
    ..However, even with a very large panel of RILs, mapping resolution may not be sufficient to identify single genes unambiguously. Our results are generally applicable to the design of RILs in other species...
  2. ncbi Methodology for the measurement of mucociliary function in the mouse by scintigraphy
    W M Foster
    Department of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Appl Physiol (1985) 90:1111-7. 2001
    ....
  3. ncbi Tumour blood flow changes induced by application of electric pulses
    G Sersa
    Department of Tumour Biology, Institute of Oncology, Ljubljana, Slovenia
    Eur J Cancer 35:672-7. 1999
    ..Tumour blood flow reduction by electric pulses could have potential in exploiting modalities mediated by tumour hypoxia, e.g. activation of bioreductive agents...
  4. pmc Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates
    Kirsten Nielsen
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Infect Immun 71:4831-41. 2003
    ..Our studies highlight a role for sexual recombination in the evolution of a human fungal pathogen and provide a robust genetic platform to establish the molecular determinants of virulence...
  5. ncbi Butylated hydroxytoluene (BHT) induction of pulmonary inflammation: a role in tumor promotion
    A K Bauer
    Department of Pharmacology, University of Colorado Health Sciences Center, C238, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Exp Lung Res 27:197-216. 2001
    ..Inflammatory mediators may provide targets for early diagnosis and chemoprevention...
  6. pmc Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice
    A Fortin
    Department of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6
    Proc Natl Acad Sci U S A 98:10793-8. 2001
    ..Our findings provide an entry point for parallel association studies in humans between the syntenic 4q21-4q25 region and susceptibility to disease in endemic areas of malaria...
  7. ncbi The neuronal apoptosis inhibitory protein (Naip) is expressed in macrophages and is modulated after phagocytosis and during intracellular infection with Legionella pneumophila
    E Diez
    Department of Biochemistry, McGill University, Montreal, Canada
    J Immunol 164:1470-7. 2000
    ....
  8. pmc Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements
    Ying Zhang
    Terry Fox Laboratory, BC Cancer Research Centre, Vancouver, British Columbia, Canada
    PLoS Genet 4:e1000007. 2008
    ..These extreme levels of polymorphism suggest that ERV insertions play a significant role in genetic drift of mouse lines...
  9. ncbi Reduced tumor oxygenation by treatment with vinblastine
    G Sersa
    Department of Tumor Biology, Institute of Oncology Ljubljana, Zaloska 2, SI 1000 Ljubljana, Slovenia
    Cancer Res 61:4266-71. 2001
    ....
  10. ncbi Early recruitment of neutrophils determines subsequent T1/T2 host responses in a murine model of Legionella pneumophila pneumonia
    K Tateda
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 166:3355-61. 2001
    ..pneumophila infection, not via direct killing but more immunomodulatory effects. Our results suggest that the early recruitment of neutrophils may contribute to T1 polarization in a murine model of L. pneumophila pneumonia...
  11. ncbi IL-12 is required for antibody-mediated protective immunity against blood-stage Plasmodium chabaudi AS malaria infection in mice
    Zhong Su
    Center for the Study of Host Resistance, Montreal General Hospital Research Institute, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada
    J Immunol 168:1348-55. 2002
    ....
  12. ncbi Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application
    R Kircheis
    Boehringer Ingelheim Austria, Dr Boehringer Gasse 5-11, A-1121 Vienna, Austria
    Gene Ther 8:28-40. 2001
    ..In the tumor, DNA was associated mainly with tumor cells and frequently found near structures which resemble primitive blood vessels...
  13. ncbi The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells
    Jennifer L Brogdon
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 168:3825-32. 2002
    ..These data provide a model for how the strength of TCR signaling can influence the generation of Th1 and Th2 cells...
  14. ncbi A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes
    Hiroki Nagai
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 295:679-82. 2002
    ..pneumophila. Translocation of RalF protein through the phagosomal membrane is a dot/icm-dependent process. Thus, RalF is a substrate of the Dot/Icm secretion apparatus...
  15. pmc A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death
    Rita K Laguna
    Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 103:18745-50. 2006
    ..Defective intracellular growth of the sdhA(-) mutant could be partially suppressed by the action of caspase inhibitors, but caspase-independent cell death pathways eventually aborted replication of the mutant...
  16. pmc Increased platinum accumulation in SA-1 tumour cells after in vivo electrochemotherapy with cisplatin
    M Cemazar
    Institute of Oncology, Ljubljana, Slovenia
    Br J Cancer 79:1386-91. 1999
    ..In addition, besides electroporation, immune system and tumour blood flow changes could be involved in the observed anti-tumour effectiveness of electrochemotherapy...
  17. ncbi Monokine induced by IFN-gamma is a dominant factor directing T cells into murine cardiac allografts during acute rejection
    M Miura
    Urological Institute and Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 167:3494-504. 2001
    ..Although Mig antagonism delays acute heart allograft rejection, the results also suggest that the alloimmune response circumvents Mig antagonism through alternative mechanisms...
  18. ncbi Persistence of physiological self antigen is required for the regulation of self tolerance
    K M Garza
    Departments of Microbiology and Pathology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 164:3982-9. 2000
    ..In contrast, exposure to endogenous ovarian Ag confined to the neonatal period is insufficient for the induction and maintenance of tolerance to ZP3...
  19. ncbi Genetic control of blood parasitaemia in mouse malaria maps to chromosome 8
    A Fortin
    Nat Genet 17:382-3. 1997
  20. pmc A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth
    Vicki P Losick
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 150 Harrison Ave, Boston, MA 02111, USA
    Infect Immun 77:196-204. 2009
    ..Therefore, one of these mutations may be critical for restriction of L. pneumophila intracellular growth, and this parallels results found with human NLR variants with defects in the innate immune response...
  21. pmc Strong position-dependent effects of sequence mismatches on signal ratios measured using long oligonucleotide microarrays
    Catriona Rennie
    Biosciences Building, School of Biological Sciences, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK
    BMC Genomics 9:317. 2008
    ..Sequence mismatches between probe and target strands are known to affect the stability of the probe-target duplex, and hence the strength of the observed signals from microarrays...
  22. pmc High-resolution genetic and physical map of the Lgn1 interval in C57BL/6J implicates Naip2 or Naip5 in Legionella pneumophila pathogenesis
    J D Growney
    Harvard Medical School Department of Genetics, Boston, Massachusetts 02115, USA
    Genome Res 10:1158-71. 2000
    ..Our genetic map suggests the presence of two hotspots of recombination within the Naip array, indicating that the 3' portion of Naip may be involved in the genomic instability at this locus...
  23. pmc Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus-infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-a
    Alexis Garcia
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave 16 825, Cambridge, MA 02139, USA
    Infect Immun 76:1866-76. 2008
    ..The use of AB6F1 and B6AF1 mice, as well as genetically engineered mice, on a C57BL/6 background will allow studies investigating the role of chronic microbial hepatitis and steatohepatitis in the pathogenesis of liver cancer...
  24. ncbi Behavioural analysis of four mouse strains in an anxiety test battery
    M M van Gaalen
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804, Munich, Germany
    Behav Brain Res 115:95-106. 2000
    ..In addition, the data indicate that different anxiety paradigms tax different aspects of anxiety, suggesting that a battery of different tests should be used in studies of anxiety-related behaviour...
  25. ncbi Pyruvate kinase deficiency in mice protects against malaria
    Gundula Min-Oo
    Department of Biochemistry, McGill University, Montreal, QC H3G 1Y6, Canada
    Nat Genet 35:357-62. 2003
    ..These results suggest that pyruvate kinase deficiency may similarly protect humans against malaria...
  26. pmc Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype
    Jessica J Nadler
    Department of Genetics, Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill 27599 7264, USA
    Genetics 174:1229-36. 2006
    ..Thus we can begin to identify expression profiles contributing to behavioral phenotypes through variation in gene expression...
  27. ncbi Endogenous oocyte antigens are required for rapid induction and progression of autoimmune ovarian disease following day-3 thymectomy
    P Alard
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 166:4363-9. 2001
    ..Similar results were obtained in mice OX at 4 wk. Thus endogenous tissue Ag are critical in autoimmune disease induction and progression that occur spontaneously upon regulatory T cell depletion...
  28. ncbi Cholangiohepatitis and inflammatory bowel disease induced by a novel urease-negative Helicobacter species in A/J and Tac:ICR:HascidfRF mice
    N H Shomer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    Exp Biol Med (Maywood) 226:420-8. 2001
    ..These results provide a new model of IBD and cholangio-hepatitis associated with a specific urease-negative, novel H. species...
  29. pmc Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death
    A B Molofsky
    Department of Microbiology and Immunology, University of Michigan Medical School, 6734 Medical Sciences Building II, Ann Arbor, MI 48109 0620, USA
    Infect Immun 73:5720-34. 2005
    ..Thus, the flagellar regulon equips the aquatic pathogen L. pneumophila to coordinate motility with multiple traits vital to virulence...
  30. ncbi In vivo tumor transfection mediated by polyplexes based on biodegradable poly(DMAEA)-phosphazene
    Holger K de Wolf
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, The Netherlands
    J Control Release 109:275-87. 2005
    ..The observed preferential tumor gene expression mediated by the p(DMAEA)-ppz polyplexes enables the application of this polymer to deliver therapeutic genes to tumors...
  31. ncbi SpoT governs Legionella pneumophila differentiation in host macrophages
    Zachary D Dalebroux
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA
    Mol Microbiol 71:640-58. 2009
    ..Thus, L. pneumophila requires SpoT to monitor FAB and to alternate between replication and transmission in macrophages...
  32. ncbi Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model
    G Min-Oo
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Genes Immun 5:168-75. 2004
    ..chabaudi infection. The possible molecular basis of the Pklr protective effect is discussed and is under current investigation in these two strains...
  33. pmc Spectrum of Legionella species whose intracellular multiplication in murine macrophages is genetically controlled by Lgn1
    H Miyamoto
    Department of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Infect Immun 64:1842-5. 1996
    ..pneumophila strains tested was controlled by Lgn1. However, the intracellular growth of five Legionella species other than L. pneumophila was not under Lgn1's control...
  34. ncbi CD40 ligand in pathogenesis of autoimmune ovarian disease of day 3-thymectomized mice: implication for CD40 ligand antibody therapy
    Colin Sharp
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 170:1667-74. 2003
    ....
  35. ncbi Maternal autoantibody triggers de novo T cell-mediated neonatal autoimmune disease
    Yulius Y Setiady
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 170:4656-64. 2003
    ..Therefore, a new mechanism of neonatal autoimmunity is presented in which epitope-specific autoantibody stimulates de novo autoimmune pathogenic CD4(+) T cell response...
  36. pmc Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice
    Nadine De Albuquerque
    Toronto General Hospital, 585 University Ave, NCSB 11 1236, Toronto, Ontario M5G 2N2, Canada
    J Virol 80:10382-94. 2006
    ..This study describes a potentially useful small animal model of human SARS, defines its pathogenesis, and suggests treatment strategies...
  37. ncbi Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells
    Kaori Mukai
    Department of Immune Regulation, Tokyo Medical and Dental University Graduate School, Bunkyo ku, Japan
    Immunity 23:191-202. 2005
    ..These findings indicate a novel mechanism of development of chronic allergic inflammation that is induced by basophils through the interaction of antigen, IgE, and FcRI...
  38. ncbi Nonobese diabetic mice display elevated levels of class II-associated invariant chain peptide associated with I-Ag7 on the cell surface
    A Bhatnagar
    Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 166:4490-7. 2001
    ..These results indicated that an intrinsic property of I-A(g7) would affect both the quantity and the repertoire of self-peptides presented during thymic selection...
  39. pmc Plasminogen alleles influence susceptibility to invasive aspergillosis
    Aimee K Zaas
    Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Genet 4:e1000101. 2008
    ..Furthermore, we demonstrated that plasminogen directly binds to Aspergillus fumigatus. We propose that genetic variation within the plasminogen pathway influences the pathogenesis of this invasive fungal infection...
  40. ncbi Down-regulation of the SWI/SNF chromatin remodeling activity by TCR signaling is required for proper thymocyte maturation
    Kyoo Y Lee
    Department of Biological Sciences, Institute of Molecular Biology and Genetics, and Research Center for Functional Cellulomics, Seoul National University, Seoul, Korea
    J Immunol 178:7088-96. 2007
    ..Our results state, for the first time, that the chromatin remodeling activity needs to be finely controlled for proper thymocyte selection and maturation processes...
  41. ncbi Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice
    Yan Weng
    Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York 12201 0509, USA
    Cancer Res 67:7825-32. 2007
    ....
  42. pmc Contribution of NK, NK T, gamma delta T, and alpha beta T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi
    Luiz Roberto Sardinha
    Departamento de Imunologia, ICB, Av Prof Lineu Prestes, 1730, Universidade de Sao Paulo, Sao Paulo, SP CEP 05508 000, Brazil
    Infect Immun 74:2031-42. 2006
    ..cruzi...
  43. ncbi MyD88-dependent IFN-gamma production by NK cells is key for control of Legionella pneumophila infection
    Roman Spörri
    ETH Zurich, Institute for Microbiology, 8093 Zurich, Switzerland
    J Immunol 176:6162-71. 2006
    ....
  44. ncbi The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains
    Kevin Y T Thia
    Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew s Place, A Beckett Street, East Melbourne 8006, Australia
    Tissue Antigens 70:198-204. 2007
    ..Unlike the protease, the extended granzyme B recognition and cleavage site in Bid, a key pro-apoptotic substrate, was invariant...
  45. ncbi Ocular immune privilege promoted by the presentation of peptide on tolerogenic B cells in the spleen. II. Evidence for presentation by Qa-1
    T J D'Orazio
    Graduate Program in Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    J Immunol 166:26-32. 2001
    ....
  46. ncbi Both gamma delta T cells and NK cells inhibit the engraftment of xenogeneic rat bone marrow cells and the induction of xenograft tolerance in mice
    B Nikolic
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
    J Immunol 166:1398-404. 2001
    ..2 and anti-NK1.1 mAbs in TCRdelta(-/-) mice. Therefore, in addition to CD4 and CD8 T cells, gammadelta T cells and NK cells play a role in resisting engraftment of rat marrow and the induction of xenograft tolerance in mice...
  47. ncbi The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo
    Hisaya Akiba
    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
    J Immunol 175:2340-8. 2005
    ..These results indicated that the ICOS/B7RP-1 interaction plays an essential role in the development of CXCR5+ T(FH) cells in vivo...
  48. ncbi Iodine and IFN-gamma synergistically enhance intercellular adhesion molecule 1 expression on NOD.H2h4 mouse thyrocytes
    Rajni B Sharma
    Department of Pathology, School of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Immunol 174:7740-5. 2005
    ..These findings suggest that iodine and IFN-gamma cooperate to promote thyroidal expression of ICAM-1 in this mouse model of thyroiditis, highlighting the complex interplay present in the pathogenesis of Hashimoto's thyroiditis...
  49. ncbi H-41, a new minor histocompatibility locus. I. Histogenetic analysis
    A Juretic
    J Immunol 133:2950-4. 1984
    ..The B10.STA10 anti-B10.STA12 CTL exhibit, in addition, a cross-reactivity with B10.SAA48 cells that may be directed at one of the alloantigens controlled by the H-2 haplotype of this strain...
  50. ncbi Mechanisms of enhanced macrophage-mediated prostaglandin E2 production and its suppressive role in Th1 activation in Th2-dominant BALB/c mice
    Etsushi Kuroda
    Department of Immunology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    J Immunol 170:757-64. 2003
    ....
  51. ncbi Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence
    B Kest
    Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York, 10314, USA
    Neuroscience 115:463-9. 2002
    ..The data also demonstrate that the differential genetic liability to morphine physical dependence begins with, and is predicted by, the first morphine exposure...
  52. ncbi Costimulation of multiple NK cell activation receptors by NKG2D
    Emily L Ho
    Division of Rheumatology Howard Hughes Medical Institute, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110, USA
    J Immunol 169:3667-75. 2002
    ..1, or Ly-49D) and NKG2D leads to augmentation of cytokine release compared with stimulation through the activation receptor alone. These results demonstrate that NKG2D has the ability to costimulate multiple NK activation receptors...
  53. ncbi Mouse strain variation in maximal electroshock seizure threshold
    Thomas N Ferraro
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, 415 Curie Blvd, Philadelphia, PA 19104 6140, USA
    Brain Res 936:82-6. 2002
    ..We conclude that MEST represents a useful tool for dissecting the multifactorial nature of seizure sensitivity in mice...
  54. ncbi Analysis of lung tumorigenesis in chimeric mice indicates the Pulmonary adenoma resistance 2 (Par2) locus to operate in the tumor-initiation stage in a cell-autonomous manner: detection of polymorphisms in the Poli gene as a candidate for Par2
    Gang Hong Lee
    Department of Pathology, Toramomon Hospital and Okinaka Memorial Institute for Medical Research 2 2 2 Toranomon, Minatoku, Tokyo 105 8470, Japan
    Oncogene 22:2374-82. 2003
    ..Consequently, the Poli is an intriguing Par2 candidate clearly deserving further evaluation...
  55. ncbi The heritability of antinociception: common pharmacogenetic mediation of five neurochemically distinct analgesics
    Sonya G Wilson
    Department of Psychology and Program in Neuroscience, University of Illinois at Urbana Champaign, Champaign, Illinois, USA
    J Pharmacol Exp Ther 304:547-59. 2003
    ..However, the genes in question may affect antinociception indirectly, via a primary action on baseline nociceptive sensitivity...
  56. ncbi Mapping blood pressure loci in (A/J x B6)F2 mice
    David D L Woo
    David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Physiol Genomics 15:236-42. 2003
    ..Defining the molecular differences between the A/J and the B6 alleles at these novel loci with major influences on the BP phenotype will contribute to our understanding of the complex genetics of BP control...
  57. ncbi Regulation of CD103 expression by CD8+ T cells responding to renal allografts
    Donghua Wang
    Department of Surgery, University of Maryland Medical School, 10 South Pine Street, Baltimore, MD 21201, USA
    J Immunol 172:214-21. 2004
    ..These data support a model in which TGF-beta activity present locally at the graft site plays a critical role in regulating CD103 expression, and hence the epitheliotropism, of CD8 effector populations that infiltrate renal allografts...
  58. ncbi Fine chromosomal localization of the mouse Par2 gene that confers resistance against urethane-induction of pulmonary adenomas
    G H Lee
    Department of Pathology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, Tokyo 105 8470, Japan
    Oncogene 20:3979-85. 2001
    ..The map information obtained in this study should enable subsequent positional cloning of the Par2 gene...
  59. ncbi Strain distribution pattern of susceptibility to immune-mediated nephritis
    Chun Xie
    Simmons Arthritis Research Center, Division of Rheumatology, Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 172:5047-55. 2004
    ..Detailed studies to dissect out the immunological and genetic basis of renal disease in these three strains are clearly warranted...
  60. ncbi Alternative splicing of the K-ras gene in mouse tissues and cell lines
    Y Wang
    Medical College of Ohio, Toledo, Ohio, USA
    Exp Lung Res 27:255-67. 2001
    ....
  61. ncbi Definition of a new T lymphocyte cell surface antigen, Ly 11.2
    D Meruelo
    J Immunol 125:2713-8. 1980
    ..Although the locus coding for this antigen appears to be closely linked to the minor histocompatibility locus H-30 and to the locus coding for Ly 6.2, a chromosome assignment has not yet been made for my of these loci...
  62. ncbi CTL and serologically defined antigens of B2m,H-3 region
    M E Kurtz
    J Immunol 135:2847-52. 1985
    ..These loci have been separated by recombination from H-42 in the production of the congenic strain B10.FS-a. A gene order of B2m, H-3, H-42 is suggested...
  63. ncbi Genetics of resistance to infection with Salmonella typhimurium in mice
    J Plant
    J Infect Dis 133:72-8. 1976
    ..However, as previously demonstrated in the parent strains, resistance in the hybrids was related to the ability to produce a good delayed-type hypersensitivity reaction to an extract of S. typhimurium...
  64. ncbi Cellular mechanisms of genetically controlled host resistance to Mycobacterium bovis (BCG)
    P Gros
    J Immunol 131:1966-72. 1983
    ....
  65. ncbi Linkage of a 7S RNA sequence and kappa light chain genes in the mouse
    B A Taylor
    Immunogenetics 22:471-81. 1985
    ..The Rn7s-6 variant is a plus/minus variant; no sequence allelic to Rn7s-6 is found in inbred strains that share the Ly-3a-Igk-Ef1a haplotype...
  66. ncbi Control of mouse hepatitis virus replication in macrophages by a recessive gene on chromosome 7
    M S Smith
    J Immunol 133:428-32. 1984
    ..We have identified and mapped a new locus that imparts resistance to productive infection of mouse hepatitis virus MHV(A59) in cultured macrophages. This locus maps 41.5 centimorgans from the albino locus on chromosome 7...
  67. ncbi The location of the C3 and GLO (glyoxalase 1) loci of the IXth linkage group in mice
    P Rubinstein
    J Immunol 122:2584-9. 1979
  68. ncbi Restriction fragment analysis of V preB and lambda 5 within the genus Mus
    L A D'Hoostelaere
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 19:37-42. 1989
    ..These results suggest that V preB1, V preB2 and lambda 5 have been present for over 12 million years...
  69. pmc A restriction fragment length polymorphism at murine Glud locus co-segregates with Rib-1, Es-10, and Tcra on chromosome 14
    J Shaughnessy
    Laboratory of Genetics, NCI, Bethesda, MD 20892
    Nucleic Acids Res 17:2881. 1989
  70. ncbi Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors
    M L Mucenski
    NCI Frederick Cancer Research Facility, BRI Basic Research Program, Maryland 21701
    Oncogene Res 2:219-33. 1988
    ..These results suggest that Evi-1 represents a new locus involved in myeloid disease...
  71. ncbi Genetic linkage of resistance to Listeria monocytogenes with macrophage inflammatory responses
    M M Stevenson
    J Immunol 127:402-7. 1981
    ....
  72. ncbi Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice
    P Gros
    J Immunol 127:2417-21. 1981
    ..The product of the Bcg gene was found to influence the early phase of host response resulting in the genetic advantage of the resistant host being demonstrable as early as 24 hr after infection...
  73. ncbi Studies on natural killer (NK) cells. I. NK cell specific antibodies in CE anti-CBA serum
    R C Burton
    J Immunol 126:1985-9. 1981
    ..2, and the corresponding antibodies as anti-NK-1.2. However, the possibility that CE anti-CBA serum detects a new system of NK-specific antigen has not been excluded...
  74. ncbi Cell-mediated cytotoxicity to non-MHC alloantigens on mouse epidermal cells. I. H-2 restricted reactions among strains sharing the H-2k haplotype
    D Steinmuller
    J Immunol 126:1747-53. 1981
  75. ncbi Evidence for a new lymphocyte-stimulating determinant (Lsd) detected by alloreactive T cell lines
    B Opalka
    Eur J Immunol 13:24-30. 1983
    ..BR anti-C57BL/10). The third clone (BD7, C57BL/6 anti-CBA/J) was probably originally directed against Lsd. So far, Lsd is only characterized by stimulation of T cell proliferation, and its physiological function is not yet known...
  76. ncbi NK-2.1: an NK-associated antigen detected with NZB anti-BALB/c serum
    S B Pollack
    J Immunol 129:2277-81. 1982
  77. ncbi Ly 9, an alloantigenic marker of lymphocyte differentiation
    B J Mathieson
    J Immunol 125:2127-36. 1980
    ..Cytotoxic elimination experiments confirm that Ly 9 is expressed on at least 2 different T cell functional subsets and B cells...
  78. pmc Molecular heterogeneity in the Major Urinary Proteins of the house mouse Mus musculus
    D H Robertson
    Department of Biochemistry and Applied Molecular Biology, UMIST, Manchester, U K
    Biochem J 316:265-72. 1996
    ..In the two strains there are at least 13 different MUPs, either observed or predicted, indicating the heterogeneity of expression of this group of proteins...
  79. ncbi A new lymphocyte cell surface antigen, Ly-22.2, controlled by a locus on chromosome 4 and a second unlinked locus
    D Meruelo
    J Immunol 130:946-50. 1983
    ..Strain distribution studies show Ly-22.2 is present in all strains examined except B10-derived congenic strains. It is of interest that C57BL/6 and C57BL/10 mice differ in the expression of this antigen...
  80. ncbi Polygenic control of the immune response to F antigen
    D M Silver
    Immunogenetics 12:237-51. 1981
    ..Such complex genetic control suggests regulation by a number of independently segregating loci whose function it is to limit the autoimmune response to F antigen...
  81. ncbi Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus
    M A DeBenedette
    Department of Immunology, University of Toronto, Ontario, Canada
    J Immunol 163:4833-41. 1999
    ..These results further substantiate the idea that different immune responses vary in their dependence on costimulation and suggest a role for 4-1BBL in augmenting suboptimal CTL responses in vivo...
  82. pmc Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice. Relationship between the molecular type of apoA-II and mouse senile amyloidosis
    K Higuchi
    Department of Senescence Biology, Kyoto University, Japan
    Biochem J 279:427-33. 1991
    ..The molecular type of apoA-II may be a factor involved in the development of senile amyloidosis in mice...
  83. ncbi Strain variation of lymphokine production and specific antibody secretion in mice infected with Mycobacterium lepraemurium
    A Hoffenbach
    Cell Immunol 91:1-11. 1985
    ..The level of anti-MLM antibodies was found to be higher in C57BL/6, BALB/c and A/J mice than in the other strains tested. Thus no evidence appeared of a direct influence of the Bcg gene on lymphokine production and antibody secretion...
  84. pmc Transporters associated with antigen processing (TAP)-independent presentation of soluble insulin to alpha/beta T cells by the class Ib gene product, Qa-1(b)
    S M Tompkins
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Exp Med 188:961-71. 1998
    ..Therefore, this class Ib protein may have access to a novel antigen processing pathway that is not available to class Ia molecules...
  85. ncbi The Ig kappa L chain allelic groups among the Ig kappa haplotypes and Ig kappa crossover populations suggest a gene order
    L A D'Hoostelaere
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
    J Immunol 141:652-61. 1988
    ....
  86. ncbi Genetic expression of aryl hydrocarbon hydroxylase induction. 3. Changes in the binding of n-octylamine to cytochrome P-450
    D W Nebert
    Mol Pharmacol 8:651-66. 1972
  87. ncbi Structural polymorphism of murine complement factor H controlled by a locus located between the Hc and the beta 2M locus on the second chromosome of the mouse
    S Natsuume-Sakai
    J Immunol 134:2600-6. 1985
    ..This was shown by phenotyping the Hc locus and H locus with backcross progenies between A/J (one of strain with H.1) and MoA (one of strain with H.2). The recombination frequency between these two loci was 0.17 +/- 0.046...
  88. ncbi Inherited immunoglobulin idiotypes of the mouse
    O Makela
    Immunol Rev 34:119-38. 1977
  89. ncbi Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides
    C E Grubin
    Department of Immunology, University of Washington, Seattle 98195, USA
    Immunity 7:197-208. 1997
    ..In addition, the data suggest that T cell receptor repertoires selected in wild-type mice and in mice displaying limited spectra of self-peptides are distinct...
  90. pmc An Eco RI restriction length polymorphism at the murine L-myc locus
    R Dolcetti
    I Centro di Riferimento Oncologico, Aviano, Italy
    Nucleic Acids Res 16:11853. 1988
  91. ncbi The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles
    P Gosselin
    Institut Armand Frappier, Universite du Quebec, Laval, Canada
    Int Immunol 9:533-40. 1997
    ..Together with our and others previous observations, these results identify the NK2.1/Ly-49C antigen as a receptor for MHC class I molecules whose expression is regulated by host MHC genes...
  92. ncbi Evidence for close linkage of a mouse light chain marker with the Ly-2,3 locus
    D M Gibson
    J Immunol 121:1585-90. 1978
    ..6 map units) to the Ly-2,3 locus on mouse Chromosome 6. The locus controlling normal light chain IF-patterns has been designated Ef1...
  93. ncbi Fen1 mutations result in autoimmunity, chronic inflammation and cancers
    Li Zheng
    Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, California 91010, USA
    Nat Med 13:812-9. 2007
    ....
  94. pmc B-lymphocyte Fc receptor-associated non-H-2 antigens are determined by a single polymorphic locus which is linked to the Mls locus
    H B Dickles
    J Exp Med 146:1678-92. 1977
    ..The other (Mls locus) determines antigens which are stimulatory in mixed lymphocyte cultures. These observations suggest that there may be a second gene complex which is the analogue of the I region of the H-2 complex...
  95. ncbi Sex significantly influences transduction of murine liver by recombinant adeno-associated viral vectors through an androgen-dependent pathway
    Andrew M Davidoff
    Department of Surgery, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 102:480-8. 2003
    ..These results have significant implications for gene therapy of autosomal and acquired disorders affecting the liver...
  96. ncbi Legionella pneumophila couples fatty acid flux to microbial differentiation and virulence
    Rachel L Edwards
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA
    Mol Microbiol 71:1190-1204. 2009
    ..pneumophila swiftly acclimates to stresses encountered in its host or the environment, thereby enhancing its overall fitness...
  97. ncbi The novel CD4+CD25+ regulatory T cell effector molecule fibrinogen-like protein 2 contributes to the outcome of murine fulminant viral hepatitis
    Itay Shalev
    Multi Organ Transplant Program, University of Toronto, Toronto, Ontario, Canada
    Hepatology 49:387-97. 2009
    ..Adoptive transfer of wild-type Tregs into resistant fgl2(-/-) mice increased their mortality caused by MHV-3 infection, whereas transfer of peritoneal exudate macrophages had no adverse effect...
  98. ncbi Mast cells express novel functional IL-15 receptor alpha isoforms
    Elena Bulanova
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    J Immunol 170:5045-55. 2003
    ..Taken together, our data indicate that murine mast cells express novel, fully functional IL-15R alpha isoforms, which can explain the selective regulatory effects of IL-15 on these cells...
  99. ncbi Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction
    Gregory S Jack
    Department of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    J Urol 174:2041-5. 2005
    ..We performed a pilot study to investigate the ability of human adipose derived, multipotent stem cells to be delivered to and survive within bladder and urethral smooth muscle...
  100. ncbi The targeting of anionized polyvinylpyrrolidone to the renal system
    Hiroshi Kodaira
    Graduate School of Pharmaceutical Sciences, Department of Biopharmaceutics, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biomaterials 25:4309-15. 2004
    ..Thus, these carboxylated and sulfonated PVPs may be useful polymeric carriers for drug delivery to the kidney and bladder, respectively...
  101. pmc Effects of buspirone on posthypoxic ventilatory behavior in the C57BL/6J and A/J mouse strains
    Motoo Yamauchi
    Department of Medicine, Case Western Reserve University, VA Medical Center, Research Service K216, 10701 East Blvd, Cleveland, OH 44106, USA
    J Appl Physiol (1985) 105:518-26. 2008
    ..We conclude that buspirone improves posthypoxic ventilatory irregularities in the B6 mouse through its agonist effects on the 5-HT1A receptor...

Research Grants66

  1. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004
    ..Eventually, these preclinical studies in an animal model of "former smokers" will help to evaluate the potential usefulness and also possible dosage regimens of chemopreventive agents characterized by their suppressing action. ..
  2. INIA: System Mechanisms in Stress-Alcohol Interactions
    Douglas Matthews; Fiscal Year: 2006
    ..These studies will fill a major gap in understanding the relationship between stress, brain regions, genetics and the development of excessive drinking. ..
  3. GABAa receptor g[2] knockout: ethanol and spatial memory
    Douglas Matthews; Fiscal Year: 2006
    ..0 mg/kg). These studies will directly determine if alterations in GABAA receptor composition via targeted genetic alteration in the gamma2 subunit of the GABAA receptor alter ethanol impairment of spatial memory. ..
  4. Genetics of Autontibody Diversification
    Umesh Deshmukh; Fiscal Year: 2008
    ..The proposal addresses a significant issue in autoimmunity and will serve well as a training vehicle to obtain the stated goals by the PI. ..
  5. Central Serotonergic Pathways Regulating Energy Balance
    LORA HEISLER; Fiscal Year: 2007
    ....
  6. MOLECULAR BIOLOGY AND PATHOGENESIS OF MOUSE ADENOVIRUS
    KATHERINE SPINDLER; Fiscal Year: 2007
    ..These studies will further our knowledge of adenovirus biology, host immune mechanisms and viral immune evasion. ..
  7. Hostility, Race, and Glucose Metabolism
    Richard Surwit; Fiscal Year: 2006
    ..These studies will further our understanding of the differences in the etiology of diabetes in these ethnic groups and may help explain the racial disparity in this disease. ..
  8. ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICE
    LINDA TOTH; Fiscal Year: 2006
    ..The data should reveal new and practical strategies for relief of post-procedural pain in mice. ..
  9. Autoimmune Oophoritis: Consequences of Gamete Vaccines
    Kenneth Tung; Fiscal Year: 2006
    ..Specifically, we will determine the immunogenetic regulation of the immune response to CP2, and the influence of the B cell epitope specificity of the ZP Ab on the induction of progenic AOD. ..
  10. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
    ..Steven Tannenbaum (MIT), Dr. Jack Henningfield (Johns Hopkins and Pinney Associates), Drs. Jeffrey Seeman and Anthony Tricker (Philip Morris), and Dr. John Lauterbach (an independent consultant, formerly with Brown and Williamson). ..
  11. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  12. Gene Methylation and Therapeutic Response in Lung Cancer
    Steven Belinsky; Fiscal Year: 2005
    ..The validation of these genes as biomarkers of lung cancer risk and their detection in sputum and/or serum could ultimately support chemoprevention trials for preventing lung cancer. ..
  13. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2008
    ..abstract_text> ..
  14. Dissection of Muscle Weight QTL Via Congenic Strains
    Arimantas Lionikas; Fiscal Year: 2008
    ..3) Using a bioinformatics approach, search for candidate genes within the region of Chr 9 defined by congenic strain analysis with the potential to influence muscle weight. [unreadable] [unreadable] [unreadable]..
  15. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  16. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2010
    ..These studies will provide insights into pathogenesis of lupus nephritis and identify checkpoints for intervention in patients. ..
  17. Molecular pathogenesis of Francisella tularnesis
    YOUSEF A ABU KWAIK; Fiscal Year: 2010
    ..The bacterial effectors involved in exploiting the macrophage are potential targets for treatment as well as potential vaccine candidates. ..
  18. TUMOR SUPPRESSOR GENE METHYLATION IN LUNG ADENOCARCINOMA
    Steven A Belinsky; Fiscal Year: 2010
    ..Transient transfection of minimized promoters into cell lines with an endogenously active or silenced gene will be used to elucidate the sequence of changes involved in repression of promoter activity. REVISED: July 7, 2005 ..
  19. Monoclonal antibodies to inhibit Aspergillus germination
    MARTA L FELDMESSER; Fiscal Year: 2010
    ..It is anticipated that this study will identify fungal molecules important for germination and begin to define their interaction with host immune responses. ..
  20. LANGERHANS CELLS AND NERVES: BIDIRECTIONAL SIGNALING
    Richard Granstein; Fiscal Year: 2009
    ..Immune responses in the skin. ..
  21. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  22. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  23. IMMUNODEFICIENCIES THAT IMPAIR LYMPHOCYTE SURVIVAL
    Robert Woodland; Fiscal Year: 2009
    ..Understanding the mechanism of B cell HP will provide new strategies for effecting immune reconstitution in the aged or immunodeficient or following chemotherapy or recovery from lymphotoxic infections. ..
  24. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  25. A Molecular Investigation of Growth and Shape Variation in Cleft-Lip Etiology
    Nathan Young; Fiscal Year: 2008
    ..In turn, this predictive power will help doctors plan more effective treatments of diseases associated with defects in growth. [unreadable] [unreadable] [unreadable]..
  26. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  27. The Pore-forming Toxin of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2003
    ..Our studies on L. pneumophila may provide a paradigm for other vacuolar intracellular pathogens such as Mycobacterium, Salmonella, and Chlamydia. ..
  28. Monoclonal antibodies for invasive aspergillosis
    Marta Feldmesser; Fiscal Year: 2003
    ..To determine the biological activity of MAbs generated in Aim 2 in murine models of invasive aspergillosis. It is anticipated that this study will identify important targets for further investigation. ..
  29. Apoptosis-Resistant Langerhans Cells
    Laura Timares; Fiscal Year: 2004
    ..Moreover, these experiments will lay the foundation toward achieving exogenous control of engineered DC gene expression and, in this case, longevity in vivo. ..
  30. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..abstract_text> ..
  31. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  32. PHARMACOGENOMIC STUDY OF ANTICONVULSANT THERAPY
    THOMAS FERRARO; Fiscal Year: 2003
    ....
  33. DIFFERENTIAL RESPONSE TO CBT IN TYPE 1 & TYPE 2 DIABETES
    Richard Surwit; Fiscal Year: 2003
    ..Changes in cortisol and self-care are predicted to impact blood glucose levels to a greater extent in type 1 diabetes because these individuals are metabolically more sensitive to any variation. ..
  34. PHENOTYPE DEFINITION IN THE GENETICS OF EPILEPSY
    Melodie Winawer; Fiscal Year: 2004
    ..Drs. R. Ottman, W.A. Hauser, S. Hodge, T. C. Gilliam and M. Morrell will provide guidance in these endeavors. ..
  35. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  36. MECHANISM OF INDUCTION OF OLFACTORY TUMORS BY ALACHLOR
    Mary Beth Genter; Fiscal Year: 2002
    ....
  37. Characterization of the Murine pcy Mutation
    David Woo; Fiscal Year: 2005
    ..abstract_text> ..
  38. Acuson Sequoia Ultrasonograph
    Brian Hoit; Fiscal Year: 2003
    ....
  39. COCKROACH ALLERGEN EXPOSURE IN CHILDHOOD ASTHMA
    Sampson Sarpong; Fiscal Year: 2002
    ..Insights gained from this work may lead to preventive measures which may reduce the prevalence and morbidity of childhood asthma. ..
  40. Control of Physical Activity by Genetic Factors
    J Lightfoot; Fiscal Year: 2003
    ..This will be the first project investigating the genetic basis of physical activity level to use these techniques that have already proven successful in other fields (e.g. cystic fibrosis). ..
  41. Sleep and fatigue during renal disease in mice
    LINDA TOTH; Fiscal Year: 2008
    ..Achieving this ambitious goal is feasible given the experience of my laboratory in surveying sleep phenotypes in other studies involving large numbers of mice. [unreadable] [unreadable]..
  42. Calcium for Prevention of Postpartum Depression
    Daniel Hatton; Fiscal Year: 2004
    ..A significantly smaller proportion in the calcium group will be taken as evidence in support of the hypothesis. Positive results from this trial will provide a strong foundation for a multicenter intervention trial. ..
  43. Cloning a major gene for mouse adenovirus susceptibility
    Katherine R Spindler; Fiscal Year: 2010
    ..The project is expected to identify a previously undescribed intractiorT^ieT^eerrK6sfiTrTrmrne res immune evasion, thus increasing our understanding of viral infections and mechanisms of host response to pathogens. ~ ..
  44. Regulatory T cells in Systemic Lupus Erythematosus
    Harini Bagavant; Fiscal Year: 2007
    ..This award will help to overcome the lag period in my career induced by my leave of absence and return to a new field of study, and will facilitate my aim of becoming an independent scientist. ..
  45. Aspergillosis: Engineering Antibody for Diagnosis
    Marta Feldmesser; Fiscal Year: 2006
    ..The availability of reagents that have potential to improve both sensitivity and specificity of galactomannan detection would be a significant advance. ..
  46. Human B cell homeostasis in a new transgenic xenochimera
    Robert Woodland; Fiscal Year: 2005
    ..Furthermore, These transgenic mice will form the basis of a new test system to study the efficacy of adjuvants and vaccines currently being developed against agents of bioterrorism. ..
  47. Vaccine Development: Purinergic Agonists as Adjuvants
    Richard Granstein; Fiscal Year: 2005
    ..5) This work may provide insights into the physiological processes that modulate the immune response and further our understanding of the mechanisms of established adjuvants. ..
  48. Facility renovation to expand mouse barrier space
    LINDA TOTH; Fiscal Year: 2005
    ..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
  49. Mechanism of Anticarcinigenic Effects of Myristicin
    HASSAN AHMAD; Fiscal Year: 2004
    ..The results are expected to help us understand the Phase-II enzyme induction by myristicin and its potential in developing pharmacologically effective dietary strategies for cancer chemoprevention. ..
  50. CO-CARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITES
    Lisa Peterson; Fiscal Year: 2006
    ..In addition, this mechanism is likely applicable to other unsymmetric nitrosamines as well as carcinogenic mixtures such as tobacco smoke, a known human carcinogen. ..
  51. Role of O6-alkylguanine in nitrosamine-induced cancers
    Lisa Peterson; Fiscal Year: 2009
    ..These studies will set the stage for a molecular epidemiological study to determine whether individuals who are unable to repair this mutagenic adduct are at increased risk of tobacco-related cancers. ..
  52. Receptor-Mediated Endocytosis of Legionella Pneumophila
    Yousef Abu Kwaik; Fiscal Year: 2004
    ..Our studies may uncover potential pathogenic evolution of Lpn to invade the more evolved mammalian cells, and may contribute to the understanding of invasion of protozoa by Mycobacterium and Chlamydia. ..
  53. Enhancing Recovery of Muscle after Rotator Cuff Repair
    Elisabeth Barton; Fiscal Year: 2006
    ..Ultimately, the goal the of proposed study is to develop appropriate therapeutic strategies for the treatment of rotator cuff injury. ..
  54. IBANGS Annual Meeting support
    John Crabbe; Fiscal Year: 2005
    ..This young society represents an opportunity to attract a core group of young investigators to alcohol research during their formative years. ..
  55. Transcriptome and Proteome Analysis of Mouse Inner Ears
    Qing Zheng; Fiscal Year: 2007
    ..Genes, proteins and their molecular pathways identified in this proposed research are potential targets of drug therapies for hearing loss that affects more than 28 million Americans. ..
  56. Genetic Determinants of A. Fumigatus Susceptibility
    Aimee Zaas; Fiscal Year: 2008
    ..fumigatus infection, this proposal will identify and characterize genetic polymorphisms related to IA susceptibility in mice and validate these findings in a cohort of human bone marrow transplant donors and recipients. ..
  57. BEHAVIORAL AND PHYSIOLOGIC PATHOBIOLOGY OF MICE
    LINDA TOTH; Fiscal Year: 2006
    ..abstract_text> ..
  58. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2006
    ..These studies are expected to yield new insights on fundamental aspects of antibody function as well as practical information for the development of second generation antibody reagents for human therapy. ..
  59. MARKERS FOR LUNG CARCINOGENESIS IN BRONCHIAL EPITHELIUM
    Steven Belinsky; Fiscal Year: 2001
    ..f., simply markers of exposure) and help identify genetic alterations that are candidate markers of respiratory carcinogenesis. ..
  60. N ACETYLTRANSFERASES--GENOTYPES AND GENOTOXICITY
    CHARLENE MCQUEEN; Fiscal Year: 2002
    ..These studies will show whether 4AB genotoxicity is modulated by Nat expression. The results will provide insight into genetic regulation of susceptibility to a carcinogen found in tobacco smoke. ..
  61. CORNEAL ENDOTHELIAL CELL IMMUNOREGULATORY FACTORS
    DALE GREGERSON; Fiscal Year: 2003
    ..identify the activity(s) to learn if it is a known factor(s); and 3. if the activity has not already been described, continue characterization of the factor(s) and mechanism of action. ..
  62. ARYLAMINE ACETYLTRANSFERASES AND DEVELOPMENTAL TOXICITY
    CHARLENE MCQUEEN; Fiscal Year: 2002
    ..Such information would be useful in understanding potential human risk pregnancy and development, by identifying susceptible genotypes. ..
  63. GENETICS OF A NEW MOUSE MODEL FOR DEAFNESS
    Qing Zheng; Fiscal Year: 2002
    ..Aim 2. Construct a physical contig of YACS and BACS clones across the minimal genetic region. Aim 3. Fully characterize the development and pathology of inner ears from hml/hml mice compared with hml/+ and +/+ controls. ..