inbred strains rats

Summary

Summary: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.

Top Publications

  1. ncbi Capture of authentic embryonic stem cells from rat blastocysts
    Mia Buehr
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, Edinburgh EH93JQ, UK
    Cell 135:1287-98. 2008
  2. ncbi Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart
    Martine Desrois
    University Laboratory of Physiology, University of Oxford, Oxford, England, UK
    Cardiovasc Res 61:288-96. 2004
  3. ncbi Positional identification of Ncf1 as a gene that regulates arthritis severity in rats
    Peter Olofsson
    Section for Medical Inflammation Research and Department of Cell and Molecular Biology, Solvegatan 19, I11 BMC, Lund University, S 22184 Lund, Sweden
    Nat Genet 33:25-32. 2003
  4. ncbi Distribution and functional impact of DNA copy number variation in the rat
    Victor Guryev
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Nat Genet 40:538-45. 2008
  5. ncbi Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood-retinal barrier permeability
    A Carmo
    Center of Opthalmology, Institute for Biomedical Research on Light and Image, University of Coimbra, Coimbra, Portugal
    Nitric Oxide 4:590-6. 2000
  6. ncbi Decreased blood glucose excursion by nateglinide ameliorated neuropathic changes in Goto-Kakizaki rats, an animal model of non-obese type 2 diabetes
    Yoshiro Kitahara
    Pharmaceutical Research Laboratories, Ajinomoto, Kawasaki, Japan
    Metabolism 51:1452-7. 2002
  7. ncbi SNP and haplotype mapping for genetic analysis in the rat
    Kathrin Saar
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strae 10, 13125 Berlin, Germany
    Nat Genet 40:560-6. 2008
  8. ncbi MHC class II compartment, endocytosis and phagocytic activity of macrophages and putative dendritic cells isolated from normal tissues rich in synovium
    Mahin Moghaddami
    Arthritis Research Laboratory, Hanson Institute for Medical Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Int Immunol 17:1117-30. 2005
  9. ncbi MHC II+ CD45+ cells from synovium-rich tissues of normal rats: phenotype, comparison with macrophage and dendritic cell lineages and differentiation into mature dendritic cells in vitro
    Mahin Moghaddami
    Arthritis Research Laboratory, Hanson Institute for Medical Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Int Immunol 17:1103-15. 2005
  10. pmc Heritability and tissue specificity of expression quantitative trait loci
    Enrico Petretto
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom
    PLoS Genet 2:e172. 2006

Detail Information

Publications189 found, 100 shown here

  1. ncbi Capture of authentic embryonic stem cells from rat blastocysts
    Mia Buehr
    Institute for Stem Cell Research, University of Edinburgh, King s Buildings, Edinburgh EH93JQ, UK
    Cell 135:1287-98. 2008
    ..Rat ES cells will also provide a refined test-bed for functional evaluation of pluripotent stem cell-derived tissue repair and regeneration...
  2. ncbi Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart
    Martine Desrois
    University Laboratory of Physiology, University of Oxford, Oxford, England, UK
    Cardiovasc Res 61:288-96. 2004
    ..The aim of this work was to define the insulin response in hearts of the Goto-Kakizaki (GK) rat, a polygenic model of spontaneous type 2 diabetes...
  3. ncbi Positional identification of Ncf1 as a gene that regulates arthritis severity in rats
    Peter Olofsson
    Section for Medical Inflammation Research and Department of Cell and Molecular Biology, Solvegatan 19, I11 BMC, Lund University, S 22184 Lund, Sweden
    Nat Genet 33:25-32. 2003
    ..Hence, Ncf1 is associated with a new autoimmune mechanism leading to severe destructive arthritis, notably similar to rheumatoid arthritis in humans...
  4. ncbi Distribution and functional impact of DNA copy number variation in the rat
    Victor Guryev
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands
    Nat Genet 40:538-45. 2008
    ..These characteristics make the rat an excellent model for studying phenotypic effects of structural variation in relation to human complex traits and disease...
  5. ncbi Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood-retinal barrier permeability
    A Carmo
    Center of Opthalmology, Institute for Biomedical Research on Light and Image, University of Coimbra, Coimbra, Portugal
    Nitric Oxide 4:590-6. 2000
    ..In summary, in retinas from GK rats there is an increased production of NO which may contribute to the BRB breakdown...
  6. ncbi Decreased blood glucose excursion by nateglinide ameliorated neuropathic changes in Goto-Kakizaki rats, an animal model of non-obese type 2 diabetes
    Yoshiro Kitahara
    Pharmaceutical Research Laboratories, Ajinomoto, Kawasaki, Japan
    Metabolism 51:1452-7. 2002
    ..These results suggest that meticulous control of postprandial hyperglycemia is essential to inhibit the development of neuropathy in type 2 diabetes...
  7. ncbi SNP and haplotype mapping for genetic analysis in the rat
    Kathrin Saar
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strae 10, 13125 Berlin, Germany
    Nat Genet 40:560-6. 2008
    ..We provide a detailed SNP map and demonstrate its utility for mapping of quantitative trait loci. This community resource is openly available and augments the genetic tools for this workhorse of physiological studies...
  8. ncbi MHC class II compartment, endocytosis and phagocytic activity of macrophages and putative dendritic cells isolated from normal tissues rich in synovium
    Mahin Moghaddami
    Arthritis Research Laboratory, Hanson Institute for Medical Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Int Immunol 17:1117-30. 2005
    ..Intracellular MHC class II-rich compartments (MIIC) were prominent in sMHC IIhi cells in SRT but rare in CD163+ cells. Most MHC IIhi CD11c+ cells did not have a detectable MIIC...
  9. ncbi MHC II+ CD45+ cells from synovium-rich tissues of normal rats: phenotype, comparison with macrophage and dendritic cell lineages and differentiation into mature dendritic cells in vitro
    Mahin Moghaddami
    Arthritis Research Laboratory, Hanson Institute for Medical Research, Institute of Medical and Veterinary Science, Adelaide, South Australia
    Int Immunol 17:1103-15. 2005
    ..These results demonstrate that SRTs contain indeterminate cells that can differentiate into mature DCs in vitro in response to GM-CSF, plus mature synovial lining macrophages...
  10. pmc Heritability and tissue specificity of expression quantitative trait loci
    Enrico Petretto
    Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, United Kingdom
    PLoS Genet 2:e172. 2006
    ..We delineate the effects of genetic architecture on variation in gene expression and show the sensitivity of this experimental design to tissue sampling variability in large-scale eQTL studies...
  11. ncbi Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats: implications for theories of selective attention and arousal
    B J Cole
    Department of Experimental Psychology, University of Cambridge, U K
    Behav Brain Res 33:165-79. 1989
    ..They therefore complete a double dissociation of effects on accuracy and vigour of responding, supporting theories of a division of arousal-type processes...
  12. ncbi Evidence for common autoimmune disease genes controlling onset, severity, and chronicity based on experimental models for multiple sclerosis and rheumatoid arthritis
    K Bergsteinsdottir
    Section for Medical Inflammation Research, Lund University, Lund, Sweden
    J Immunol 164:1564-8. 2000
    ..Our results show that different phases of EAE are controlled by different sets of genes and that common genes are likely to be involved in different autoimmune diseases...
  13. ncbi Prefrontal cortical-ventral striatal interactions involved in affective modulation of attentional performance: implications for corticostriatal circuit function
    Anastasia Christakou
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 24:773-80. 2004
    ..This distinction provides an insight into the functional specialization of corticostriatal circuits in similar behavioral contexts...
  14. ncbi Heart failure progression is accelerated following myocardial infarction in type 2 diabetic rats
    Margaret P Chandler
    Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Heart Circ Physiol 293:H1609-16. 2007
    ..These results, demonstrating enhanced remodeling and LV dysfunction 8 wk postligation provide evidence of an accelerated progression of heart failure in T2D rats...
  15. ncbi Double dissociation of function within the hippocampus: a comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions
    D M Bannerman
    Department of Experimental Psychology, University of Oxford, England
    Behav Neurosci 113:1170-88. 1999
    ..1999). These results demonstrate possible functional dissociations along the septotemporal axis of the hippocampus...
  16. pmc Genetical genomic determinants of alcohol consumption in rats and humans
    Boris Tabakoff
    Department of Pharmacology, University of Colorado, Denver, Aurora, CO, USA
    BMC Biol 7:70. 2009
    ....
  17. ncbi Expression of A20 in the vessel wall of rat-kidney allografts correlates with protection from transplant arteriosclerosis
    Uta Kunter
    Division of Nephrology, Department of Medicine, Universitätsklinikum der RWTH Aachen, Aachen, Germany
    Transplantation 75:3-9. 2003
    ..Recent data suggests that grafts contribute to their own survival by way of up-regulation of "cytoprotective" genes...
  18. pmc Genome-wide association study of alcohol dependence
    Jens Treutlein
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany
    Arch Gen Psychiatry 66:773-84. 2009
    ..Identification of genes that contribute to alcohol dependence will improve our understanding of the mechanisms that underlie this disorder...
  19. pmc Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus
    John P Mordes
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, 01655, USA
    Mamm Genome 20:162-9. 2009
    ....
  20. ncbi Congenic mapping confirms a locus on rat chromosome 10 conferring strong protection against myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis
    M Jagodic
    Neuroimmunology Unit, Center for Molecular Medicine, L8 04, Karolinska Hospital, 17176 Stockholm, Sweden
    Immunogenetics 53:410-5. 2001
    ..The mechanism by which gene(s) in the region act is still unclear and will require further studies with this congenic rat strain as a tool...
  21. ncbi IL-1/IL-3 gene therapy of non-small cell lung cancer (NSCLC) in rats using 'cracked' adenoproducer cells
    M C Esandi
    Department of Molecular Cell Biology, Leiden University, The Netherlands
    Gene Ther 5:778-88. 1998
    ..These findings seem to justify further exploration of IL-1 and IL-3 gene transfer for the treatment of cancers...
  22. pmc Comparative sequence analysis of the non-protein-coding mitochondrial DNA of inbred rat strains
    Avinash Abhyankar
    Medical Genetics Unit, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden
    PLoS ONE 4:e8148. 2009
    ..Based on our analyses of conserved sequences, we propose that some of the variable nucleotide positions identified in 16S rRNA and tRNA-Cys, and the D-loop might be important for mitochondrial function and its regulation...
  23. ncbi Functional disconnection of the medial prefrontal cortex and subthalamic nucleus in attentional performance: evidence for corticosubthalamic interaction
    Yogita Chudasama
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 23:5477-85. 2003
    ..This study provides direct evidence that performance in tasks that require optimal attentional and executive control relies on a corticosubthalamic interaction within the neural circuitry of the basal ganglia...
  24. ncbi Phylogenetics of the laboratory rat Rattus norvegicus
    F Canzian
    Unit of Genetic Cancer Susceptibility, International Agency for Research on Cancer, Lyon, France
    Genome Res 7:262-7. 1997
    ..These results provide a phylogenetic basis in the choice of rat strains for genetic linkage experiments...
  25. ncbi Maternal and perinatal magnesium restriction predisposes rat pups to insulin resistance and glucose intolerance
    Lagishetty Venu
    Division of Endocrinology and Metabolism, National Institute of Nutrition, Hyderabad 500 007 India
    J Nutr 135:1353-8. 2005
    ..Thus, maternal magnesium restriction irreversibly increases body fat and induces insulin resistance in pups by 6 mo of age, whereas additional perinatal Mg deficiency impairs glucose tolerance...
  26. pmc Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome
    Steven P Wilder
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford OX3 7BN, UK
    Genome Res 14:758-65. 2004
    ..The integration of rat linkage maps in the draft genomic sequence of the rat and that of other species represents an essential step for translating rat QTL intervals into human chromosomal targets...
  27. pmc Rat Genome Database (RGD): mapping disease onto the genome
    Simon Twigger
    Bioinformatics Research Center and Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Nucleic Acids Res 30:125-8. 2002
    ..Thus, RGD is not only a valuable resource for those working with the rat but also for researchers in other model organisms wishing to harness the existing genetic and physiological data available in the rat to complement their own work...
  28. ncbi Timing of adjuvant radioimmunotherapy after cytoreductive surgery in experimental peritoneal carcinomatosis of colorectal origin
    Frits Aarts
    410 Department of Surgery, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Ann Surg Oncol 14:533-40. 2007
    ..Radioimmunotherapy (RIT) as adjuvant therapy after CS of CRC has been shown to prolong survival in preclinical studies. However, the optimal setting of RIT remains to be determined...
  29. ncbi Dysfunction of soluble guanylyl cyclase in aorta and kidney of Goto-Kakizaki rats: influence of age and diabetic state
    Klaus Witte
    Institute of Pharmacology and Toxicology, Ruprecht Karls University Heidelberg, D 68169 Mannheim, Germany
    Nitric Oxide 6:85-95. 2002
    ....
  30. ncbi Differential control over cocaine-seeking behavior by nucleus accumbens core and shell
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB1 1BB, UK
    Nat Neurosci 7:389-97. 2004
    ..These results further our understanding of how the NAc controls drug-seeking and drug-taking behavior...
  31. ncbi Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains
    Nancy E Schlick
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226 0509, USA
    Am J Physiol Cell Physiol 291:C1183-92. 2006
    ..Moreover, these data provide information that may be useful as new animal models, which result in novel combinations of nuclear and mitochondrial genomes, are developed...
  32. ncbi Gene expression in two hepatic cell lines, cultured primary hepatocytes, and liver slices compared to the in vivo liver gene expression in rats: possible implications for toxicogenomics use of in vitro systems
    Franziska Boess
    F Hoffmann La Roche Ltd, Pharmaceuticals Division, Nonclinical Development, CH 4070 Basel, Switzerland
    Toxicol Sci 73:386-402. 2003
    ..The findings are discussed with respect to the usefulness of the various hepatic in vitro systems for microarray-based toxicological testing of compounds...
  33. pmc Thermal signature analysis as a novel method for evaluating inflammatory arthritis activity
    M Brenner
    The Robert S Boas Center for Genomics and Human Genetics, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Ann Rheum Dis 65:306-11. 2006
    ....
  34. pmc Chemosensory factors influencing alcohol perception, preferences, and consumption
    Alexander A Bachmanov
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104 3308, USA
    Alcohol Clin Exp Res 27:220-31. 2003
    ..Bachmanov and Michael Tordoff); and (6) Human genetic variation in taste: connections with alcohol sensation and intake (Valerie B. Duffy and Linda M. Bartoshuk). The symposium concluded with a general discussion...
  35. ncbi Impaired glucose tolerance and insulinopenia in the GK-rat causes peripheral neuropathy
    Yuichi Murakawa
    Department of Pathology, Wayne State University, School of Medicine, Detroit, MI, USA
    Diabetes Metab Res Rev 18:473-83. 2002
    ..The effect of sustained IGT and progressive insulinopenia in the absence of overt hyperglycemia on peripheral nerve abnormalities was examined in the Goto-Kakizaki (GK)-rat...
  36. ncbi Pristane, a non-antigenic adjuvant, induces MHC class II-restricted, arthritogenic T cells in the rat
    Jens Holmberg
    Medical Inflammation Research, Lund University, Lund, Sweden
    J Immunol 176:1172-9. 2006
    ..These data suggest that the in vivo administration of a non-antigenic adjuvant, like pristane, activates CD4+ alphabetaT cells that are MHC class II restricted and arthritogenic...
  37. ncbi Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes
    Milad S Bitar
    Department of Pharmacology, Kuwait University, School of Medicine, Kuwait
    Eur J Pharmacol 511:53-64. 2005
    ..This phenomenon could play a potentially important role in the pathogenesis of diabetic endothelial dysfunction...
  38. ncbi Rat Phenome Project: the untapped potential of existing rat strains
    Tomoji Mashimo
    Institute of Laboratory Animals, Kyoto University, Graduate School of Medicine, Yoshidakonoe cho, Sakyo ku, Kyoto 606 8501, Japan
    J Appl Physiol 98:371-9. 2005
    ..All deposited strains and obtained data are freely available for any interested researcher worldwide at http://www.anim.med.kyoto-u.ac.jp/nbr...
  39. ncbi Susceptibility to autoimmune disease and drug addiction in inbred rats. Are there mechanistic factors in common related to abnormalities in hypothalamic-pituitary-adrenal axis and stress response function?
    R L Wilder
    Inflammatory Joint Diseases Section, Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bldg 10, Room 9N240, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 917:784-96. 2000
    ..These initial data, however, indicate that the genetic control of the autoimmune disease traits is highly complex...
  40. ncbi Molecular characterization of a gene in the rat homologous to human CD94
    E Dissen
    Department of Anatomy, Institute of Basic Medical Sciences, University of Oslo, Norway
    Eur J Immunol 27:2080-6. 1997
    ..The identification of a rat CD94 orthologue suggests that NK cell populations utilize two different C-type lectin receptors for MHC class I molecules in parallel...
  41. ncbi Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis
    M M Griffiths
    Department of Veterans Affairs Medical Center, and University of Utah, Salt Lake City, USA
    Arthritis Rheum 43:1278-89. 2000
    ..Collagen-induced arthritis (CIA) is a polygenic model of experimentally induced autoimmunity and chronic joint inflammation. This study maps genetic loci that regulate CIA susceptibility in DA/Bkl (DA) and BN/SsNHsd (BN) rats...
  42. pmc Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity
    S Shimizu
    Osaka University Graduate School of Medicine, Biomedical Research Center, Department of Medical Genetics, CREST of Japan Science and Technology Corporation JST, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 97:577-82. 2000
    ..These findings indicated the involvement of a different mechanism in BH3-only, protein-induced apoptogenic cytochrome c release...
  43. ncbi Genetic control of plasma lipid levels in a cross derived from normoglycaemic Brown Norway and spontaneously diabetic Goto-Kakizaki rats
    K Argoud
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    Diabetologia 49:2679-88. 2006
    ..The objective of our study was to test the genetic control of lipid metabolism in the GK rat and investigate a possible relationship with known genetic loci regulating glucose homeostasis in this strain...
  44. ncbi A linkage map of the rat genome derived from three F2 crosses
    M T Bihoreau
    Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Genome Res 7:434-40. 1997
    ..The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes...
  45. ncbi Linkage map and congenic strains to localize blood pressure QTL on rat chromosome 10
    O I Dukhanina
    Department of Physiology and Molecular Medicine, Medical College of Ohio, P O Box 10008, Toledo, Ohio 43669, USA
    Mamm Genome 8:229-35. 1997
    ..The region does not include the locus for inducible nitric oxide synthase (Nos2), which had been considered to be a candidate locus for the QTL...
  46. ncbi Identification of blood pressure quantitative trait loci that differentiate two hypertensive strains
    Michael R Garrett
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43614, USA
    J Hypertens 20:2399-406. 2002
    ..To describe genetic loci that differentiate blood pressures in two genetically hypertensive strains, the Dahl salt-sensitive (S) rat and the Albino Surgery (AS) rat...
  47. pmc The arthritis severity locus Cia5d is a novel genetic regulator of the invasive properties of synovial fibroblasts
    Teresina Laragione
    Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Arthritis Rheum 58:2296-306. 2008
    ..However, regulation of the FLS remains incompletely understood. The aim of this study was to determine whether the invasive properties of FLS are genetically regulated by arthritis severity loci...
  48. pmc An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes
    E Dissen
    Department of Anatomy, University of Oslo, Norway
    J Exp Med 183:2197-207. 1996
    ..Their cytoplasmic domains demonstrate substantial heterogeneity, consistent with the hypothesis that different Ly-49 family members may subserve different signaling functions...
  49. ncbi Renal disease susceptibility and hypertension are under independent genetic control in the fawn-hooded rat
    D M Brown
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Genet 12:44-51. 1996
    ..Our results show that susceptibility to a complication of hypertension is under at least partially independent genetic control from susceptibility to hypertension itself...
  50. ncbi Differential expression of alpha2D-adrenoceptor and eNOS in aortas from early and later stages of diabetes in Goto-Kakizaki rats
    Tsuneo Kobayashi
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, Shinagawa ku, Tokyo 142 8501, Japan
    Am J Physiol Heart Circ Physiol 287:H135-43. 2004
    ....
  51. pmc Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat
    A Y Deng
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699, USA
    J Clin Invest 95:2170-7. 1995
    ..In F2(S x MNS) functionally variant alleles at both QTL influence blood pressure, but in F2(S x WKY) only the QTL marked by Nos2 is segregating alleles influencing blood pressure...
  52. ncbi Association of the transmembrane 4 superfamily molecule CD53 with a tyrosine phosphatase activity
    A M Carmo
    MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, GB
    Eur J Immunol 25:2090-5. 1995
    ..These results demonstrate that the TM4SF members associate with tyrosine phosphatases. It seems possible that such associated phosphatases may contribute to the signal transduction capacity of TM4SF molecules...
  53. ncbi Generation of rat "supersonic" congenic/conplastic strains using superovulation and embryo transfer
    Vladimir Landa
    Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Methods Mol Biol 597:267-75. 2010
    ..Both strategies could also be combined. In the current chapter, a method for derivation of "supersonic" congenic/conplastic rat strains is described...
  54. ncbi Metastatic pattern of CC531 colon carcinoma cells in the abdominal cavity: an experimental model of peritoneal carcinomatosis in rats
    A M Lopes Cardozo
    Department of Surgery Oncology, Vrije Universteit Medical Centre, Amsterdam, The Netherlands
    Eur J Surg Oncol 27:359-63. 2001
    ....
  55. ncbi Impact of diabetes on induction of the mitochondrial permeability transition
    Paulo J Oliveira
    Centro de Neurociências de Coimbra, Unidade de Investigação Básica em Cardiologia, Universidade de Coimbra
    Rev Port Cardiol 21:759-66. 2002
    ..This could mean that cardiomyocytes from diabetic hearts may indeed be less prone to dysfunctions resulting from ischemia and reperfusion, at least in milder diabetic conditions, thus explaining many reports in the literature...
  56. pmc Characterization of thoracic duct cells that transfer polyarthritis
    L D Spargo
    The Arthritis Research Laboratory of the Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, SA, Australia
    Clin Exp Immunol 126:560-9. 2001
    ..Recruitment of these arthritogenic cells to synovium probably determines the polyarticular pattern of AA...
  57. ncbi Anatomical localization of afferent and postganglionic sympathetic neurons innervating the rat ovary
    C M Klein
    Department of Anatomy and Cell Biology, East Carolina University School of Medicine, Greenville, NC 27858 4354
    Neurosci Lett 85:217-22. 1988
    ..The significance of the dual origin of postganglionic sympathetic neurons innervating the rat ovary is not known...
  58. ncbi CD36/fatty acid translocase in rats: distribution, isolation from hepatocytes, and comparison with the scavenger receptor SR-B1
    Xingqi Zhang
    The Arthritis Research Laboratory, Hanson Centre for Cancer Research, Adelaide, South Australia, Australia
    Lab Invest 83:317-32. 2003
    ..We suggest that CD36/FAT might function in the liver as a sex-regulated accessory molecule, either in reverse cholesterol transport and/or in fatty acid uptake...
  59. ncbi Effects of sensorial denervation induced by capsaicin injection at birth or on day three of life, on puberty, induced ovulation and pregnancy
    Carolina Morán
    Biology of Reproduction Research Unit, FES Zaragoza UNAM, Mexico
    Life Sci 73:2113-25. 2003
    ..Present results could indicate that some specific neural information registered in the ovary is sent to the central nervous system, and that such information plays a role in the mechanism regulating ovarian function...
  60. ncbi Association of prolonged hyperglycemia with glomerular hypertrophy and renal basement membrane thickening in the Goto Kakizaki model of non-insulin-dependent diabetes mellitus
    A O Phillips
    Institute of Nephrology, University of Wales College of Medicine, Heath Park, Cardiff, Wales
    Am J Kidney Dis 37:400-10. 2001
    ..This model allows us to investigate further the mechanisms involved in the pathogenesis of the consequences of prolonged hyperglycemia...
  61. pmc Endostatin reduces vascularization, blood flow, and growth in a rat gliosarcoma
    Dag R Sorensen
    Department of Comparative Medicine, Rikshospitalet, University of Oslo, Norway
    Neuro Oncol 4:1-8. 2002
    ..This work verifies the general anti-angiogenic and antitumor effects of endostatin and indicates that the protein may also be considered as a treatment strategy for malignant brain tumors...
  62. ncbi Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference
    James M Murphy
    Department of Psychology, Purdue School of Science, Indiana University Purdue University Indianapolis, 46202 1375, USA
    Behav Genet 32:363-88. 2002
    ..The elucidation of the genotypes and phenotypes that result in excessive alcohol intake may lead to a better understanding of alcohol abuse and alcoholism and could guide strategies for potential treatment and prevention...
  63. ncbi Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats
    P S Gulko
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA
    Arthritis Rheum 41:2122-31. 1998
    ..To identify novel non-major histocompatibility complex (non-MHC) genetic loci controlling the severity of homologous rat type II collagen-induced arthritis (CIA)...
  64. ncbi Genetic mapping of C4 and Bf complement genes in the rat major histocompatibility complex
    W Wurst
    Abteilung Immungenetik der Universität, Gottingen, Federal Republic of Germany
    Immunogenetics 28:57-60. 1988
  65. ncbi Mapping and functional characterization of rat chromosome 4 regions that regulate arthritis models and phenotypes in congenic strains
    Liselotte Bäckdahl
    Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden
    Arthritis Rheum 48:551-9. 2003
    ..We produced congenic strains for these QTLs in order to map and characterize their impact on arthritis development...
  66. ncbi Colourful history of Japan's rat resources
    Tadao Serikawa
    Nature 429:15. 2004
  67. ncbi Correlation between cataleptic freezing and prepulse inhibition of the startle reflex in rats
    N N Barykina
    Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 10 Academician Lavrent ev Prospekt, 630090 Novosibirsk, Russia
    Neurosci Behav Physiol 34:413-6. 2004
    ....
  68. ncbi Reward and anxiety in genetic animal models of childhood depression
    O Malkesman
    Interdisciplinary Program in the Brain Sciences, Bar Ilan University, Israel
    Behav Brain Res 164:1-10. 2005
    ..The results suggest that WKY prepubertal rats are anxious and sensitive to stress-induced anhedonia, while FSL prepubertal rats exhibit none of these symptoms...
  69. ncbi Regulation of peroxisome proliferator activated receptor-gamma in rat pituitary
    R Nogueiras
    Department of Physiology, University of Santiago de Compostela, Faculty of Medicine, Santiago de Compostela, Spain
    J Neuroendocrinol 17:292-7. 2005
    ..Finally, nutritional, thyroid status or pregnancy did not change PPARgamma expression. Taken together, we provide new data regarding the regulation of pituitary PPARgamma mRNA by hormonal and metabolic status...
  70. ncbi Rat strain differences in the early stage of porcine-serum-induced hepatic fibrosis
    Yasuko Baba
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Science, The University of Tokyo, Japan
    Exp Toxicol Pathol 55:325-30. 2004
    ..In addition, the main location of inflammatory cells was different, suggesting a different role of each inflammatory cell in the process of hepatic fibrosis...
  71. ncbi The antidepressant effect of running is associated with increased hippocampal cell proliferation
    Astrid Bjørnebekk
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Int J Neuropsychopharmacol 8:357-68. 2005
    ..Thus, suppression of cell proliferation in the hippocampus could constitute one of the mechanisms that underlie depression, and physical activity might be an efficient antidepressant...
  72. ncbi Protective function of complement against alcohol-induced rat liver damage
    Igor L Bykov
    Alcohol Research Center, National Public Health Institute, POB 33, 00251 Helsinki, Finland
    Int Immunopharmacol 4:1445-54. 2004
    ..This suggests that an intact complement system has a protective function in the development of alcoholic liver damage...
  73. ncbi Inhibition of vascular endothelial growth factor (VEGF) does not affect early renal changes in a rat model of lean type 2 diabetes
    B F Schrijvers
    Medical Research Laboratories, Institute of Experimental Clinical Research, Aarhus University Hospital, Aarhus, Denmark
    Horm Metab Res 37:21-5. 2005
    ..We conclude that VEGF inhibition has minimal effects on early renal changes in GK-rats...
  74. ncbi Hepatic glycogen breakdown is implicated in the maintenance of plasma mannose concentration
    T Taguchi
    Dept of Pathobiochemistry, Faculty of Pharmacy, Meijo Univ, 150 Yagotoyama, Tempaku ku, Nagoya 468 8503, Japan
    Am J Physiol Endocrinol Metab 288:E534-40. 2005
    ..When lactate was used to perfuse the liver of fasted rats, a decrease, rather than an increase, in mannose output was observed. These findings indicate that hepatic glycogen is a source of plasma mannose...
  75. ncbi Vigabatrin in low doses selectively suppresses the clonic component of audiogenically kindled seizures in rats
    Ludmilla V Vinogradova
    Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia
    Epilepsia 46:800-10. 2005
    ....
  76. ncbi Anhedonia and motivational deficits in rats: impact of chronic social stress
    Rafal Rygula
    Department of Psychiatry and Psychotherapy, University of Gottingen, von Sieboldstr 5, D37075 Goettingen, Lower Saxony, Germany
    Behav Brain Res 162:127-34. 2005
    ..Since anhedonia is one of the core symptoms of depression in humans, our findings suggest that the rat chronic social stress model may be an appropriate model for depressive disorders...
  77. ncbi Cortical and limbic excitability in rats with absence epilepsy
    Elena A Tolmacheva
    Biological Faculty, M V Lomonosov Moscow State University, Moscow, Russia
    Epilepsy Res 62:189-98. 2004
    ..It is concluded that the elevated excitability of the limbic system or pathways mediating the spread of the epileptic activity into this system can be attributed to the development of genetic epileptic phenotype in WAG/Rij rats...
  78. ncbi Involvement of calpain isoforms in retinal degeneration in WBN/Kob rats
    Mitsuyoshi Azuma
    Research Laboratories, Senju Pharmaceutical Co Ltd, 1 5 4, Murotani, Nishiku, Kobe, Hyogo, 651 2241, Japan
    Comp Med 54:533-42. 2004
    ..Activated calpain causing proteolysis of alpha-spectrin and changes in Rt88, Rt88', Rt90 and calpain 10 may also contribute to retinal degeneration...
  79. ncbi [Induction of NO-synthase and glial fibrillary acidic protein in astrocytes of the temporal cortex in rats with audiogenic epileptiform reaction]
    S G Kalinichenko
    Morfologiia 125:68-73. 2004
    ..Astrocyte NOS and GFAP induction found in this work, suggests the participation of glia in compensatory NO-dependent mechanisms, that are formed in the damage foci of neocortex during the audiogenic seizures...
  80. ncbi Macrophages direct tumour histology and clinical outcome in a colon cancer model
    Steven J Oosterling
    Department of Surgical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    J Pathol 207:147-55. 2005
    ..The selective inhibition of macrophage functions involved in malignant progression without interfering with cytotoxic ability may therefore identify important new targets for cancer therapy...
  81. ncbi Pulmonary intravascular volume can be used for dose calculation in isolated lung perfusion
    Bart P Van Putte
    Department of Cardiothoracic Surgery, St Antonius Hospital, Nieuwegein, The Netherlands
    Eur J Cardiothorac Surg 28:594-8. 2005
    ..This may be due to the variance of lung size and pulmonary intravascular volume (PIV). Therefore, we developed a method to assess PIV and investigated the relation of PIV and dry lung weight (DLW)...
  82. ncbi Experimental alcoholism and pathogenesis of prostatic diseases in UChB rats
    Eduardo Marcelo Cândido
    Department of Anatomy, Institute of Biology, State University of Campinas UNICAMP, P O Box 6109, Campinas, 13083970 São Paulo, Brazil
    Cell Biol Int 31:459-72. 2007
    ..In conclusion, ethanol triggers alterations in prostatic epithelial and stromal compartments, affecting the stromal microenvironment and predisposing the organ to pathological processes...
  83. ncbi Stress vulnerabilities in an animal model of post-traumatic stress disorder
    Tomoki Wakizono
    Department of Psychiatry, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama 359 8513, Japan
    Physiol Behav 90:687-95. 2007
    ..Thus, we consider that the present study further validates the use of shuttle box paradigm as an animal model of PTSD by demonstrating the vulnerability due to genetic background and environmental preloaded stress...
  84. ncbi Different behaviors and different strains: potential new ways to model bipolar disorder
    Haim Einat
    University of Minnesota, College of Pharmacy, 376 Kirby Plaza, 1208 Kirby Drive, Duluth, MN 55812, USA
    Neurosci Biobehav Rev 31:850-7. 2007
    ..Both approaches will not culminate to an ideal, all encompassing model of BPD but may provide useful and relatively uncomplicated tools for research of the disorder...
  85. pmc The behavioral actions of lithium in rodent models: leads to develop novel therapeutics
    Todd D Gould
    The Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, HHS, Bldg 35, Rm 1C 912, 35 Convent Drive, Bethesda, MD 20892 3711, USA
    Neurosci Biobehav Rev 31:932-62. 2007
    ....
  86. ncbi Decreased sensitivity to thermal pain in rats bred for high anxiety-related behaviour is attenuated by citalopram or diazepam treatment
    Thomas Jochum
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07743 Jena, Federal Republic of Germany
    Behav Brain Res 183:18-24. 2007
    ....
  87. ncbi Kinetics of strain-dependent differential gene expression in oxygen-induced retinopathy in the rat
    Peter van Wijngaarden
    Department of Ophthalmology, Flinders University of South Australia, Flinders Medical Centre, Bedford Park, Adelaide, SA 5042, Australia
    Exp Eye Res 85:508-17. 2007
    ..We conclude that susceptibility to OIR correlates with differential gene expression very early in retinal microvascular development, during periods of cyclic hyperoxic exposure rather than during subsequent sustained hypoxia...
  88. ncbi The reward system and maternal behavior in an animal model of depression: a microdialysis study
    Yael Lavi-Avnon
    Department of Psychology, Bar Ilan University, Ramat Gan, Israel
    Psychopharmacology (Berl) 196:281-91. 2008
    ..In this study, we examined the rewarding value of mother-infant interaction for FSL dams...
  89. pmc Differential secretion of satiety hormones with progression of obesity in JCR:LA-corpulent rats
    Jill A Parnell
    Department of Medical Sciences, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Obesity (Silver Spring) 16:736-42. 2008
    ..To characterize the gastrointestinal tract at the onset and in well-established obesity...
  90. ncbi Vitamin A regulates obesity in WNIN/Ob obese rat; independent of stearoyl-CoA desaturase-1
    S M Jeyakumar
    Division of Biochemistry, National Institute of Nutrition ICMR, Jamai Osmania, Hyderabad 500 604, Andhra Pradesh, India
    Biochem Biophys Res Commun 370:243-7. 2008
    ..Taken together, the present data suggest that vitamin A decreases body weight gain in obese rat model independent of SCD1 gene regulation...
  91. ncbi Analysis of alcohol-related phenotypes in F2 progeny derived from FH/Wjd and ACI/N rat strains reveals independent measures and sex differences
    Biswanath Patra
    Department of Pediatrics, University of Arkansas for Medical Sciences, ACHRI, 1120 Marshall Street, Slot 512 40B, Little Rock, AR 72202, USA
    Behav Brain Res 177:37-44. 2007
    ..0001) greater effect on forced alcohol intake than the FH father. It is concluded from these analyses that alcohol-related phenotypes are segregating independently and may be influenced by maternal and sex factors...
  92. ncbi Aggressive behavior and HPA axis hormones after social isolation in adult rats of two different genetic animal models for depression
    O Malkesman
    Interdisciplinary Program in Brain Sciences, Bar Ilan University, Israel
    Behav Brain Res 175:408-14. 2006
    ..These different patterns may reflect two different types of depression. An "avoidant" or socially inhibited type of depressive-like behavior is seen most clearly in the WKY strain...
  93. ncbi Divergent anatomical pattern of D1 and D3 binding and dopamine- and cyclic AMP-regulated phosphoprotein of 32 kDa mRNA expression in the Roman rat strains: Implications for drug addiction
    M Guitart-Masip
    Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, Institute of Neuroscience, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain
    Neuroscience 142:1231-43. 2006
    ..Hence, RHA-I and RLA-I rats may be a useful tool to identify dopamine-related mechanisms that predispose to drug and alcohol dependence...
  94. ncbi Resistance to neurodegenerative brain damage in August and Wistar rats
    M G Pshennikova
    Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 139:540-2. 2005
    ..These disturbances in Wistar rats were accompanied by activation of lipid peroxidation in the hippocampus...
  95. ncbi Anxiety-like behaviors in pre-pubertal rats of the Flinders Sensitive Line (FSL) and Wistar-Kyoto (WKY) animal models of depression
    Y Braw
    Department of Psychology, Gonda Goldschmied Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan 52900, Israel
    Behav Brain Res 167:261-9. 2006
    ..Overall, the findings indicate differential expression of anxiety in pre-pubertal rats belonging to the 'depressed' strains, suggesting that these strains may be suitable for modelling different sub-groups of depression at young ages...
  96. pmc A selective COX-2 inhibitor suppresses chronic pancreatitis in an animal model (WBN/Kob rats): significant reduction of macrophage infiltration and fibrosis
    T Reding
    Pancreatitis Research Laboratory, Department of Visceral and Transplantation Surgery, University Hospital Zurich, Switzerland
    Gut 55:1165-73. 2006
    ..As COX-2 is elevated in CP, we attempted to inhibit COX-2 activity in an animal model of CP (WBN/Kob rat). We then analysed the effect of COX-2 inhibition on macrophages, important mediators of chronic inflammation...
  97. ncbi Effect of I-deprenyl and gliclazide on oxidant stress/antioxidant status and dna damage in a diabetic rat model
    Gulinnaz Alper
    Ege University Medical School, Department of Biochemistry, 35100 Bornova, Izmir, Turkey
    Endocr Res 31:199-212. 2005
    ....
  98. ncbi Effects of some neurosteroids injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy
    Rita Citraro
    Section of Pharmacology, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery, University of Catanzaro, Policlinico Mater Domini, Via T Campanella, 115, 88100 Catanzaro, Italy
    Neuropharmacology 50:1059-71. 2006
    ..These findings suggest that neurosteroids might play a role in absence epilepsies and that it might depend on the involvement of specific neuronal areas...
  99. ncbi Chronic intracerebroventricular infusion of nociceptin/orphanin FQ increases food and ethanol intake in alcohol-preferring rats
    Carlo Cifani
    Department of Experimental Medicine and Public Health, University of Camerino, Via Scalzino 5, 62032 Camerino MC, Italy
    Peptides 27:2803-10. 2006
    ..Moreover, the data suggest that continuous activation of the opioidergic N/OFQ receptor is not a suitable way to reduce alcohol abuse...
  100. ncbi Microvascular versus macrovascular dysfunction in type 2 diabetes: differences in contractile responses to endothelin-1
    Kamakshi Sachidanandam
    Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta 30912, USA
    Exp Biol Med (Maywood) 231:1016-21. 2006
    ....
  101. ncbi [Some neuroendocrinological changes in rats of cataleptic strain GC. Influences of ontogenesis and generation of breeding]
    T A Alekhina
    Ross Fiziol Zh Im I M Sechenova 92:499-505. 2006
    ..The data obtained point to peculiarities of ontogenetic regulation and to commonness of mechanisms of catalepsy and "nervousness" in GC rats...

Research Grants62

  1. Endothelin Signaling and Actions in Renal Mesangium
    Andrey Sorokin; Fiscal Year: 2013
    ..The elucidation of mechanisms of ET-1-induced renal pathologies will result in understanding of the mechanisms underlying proliferation-associated and oxidative stress related renal glomerular diseases. ..
  2. RGAP: The Heritable Transcriptome and Alcoholism
    Boris Tabakoff; Fiscal Year: 2013
    ....
  3. DOPAMINERGIC SUBSTRATES OF STARTLE GATING ACROSS SPECIES
    Neal R Swerdlow; Fiscal Year: 2013
    ..The findings will inform studies searching for the genes associated with dopamine-linked disorders of impaired sensorimotor gating in humans. ..
  4. Roles of peripheral and central respiratory chemoreceptors in inbred rat strains
    MATTHEW ROBERT HODGES; Fiscal Year: 2010
    ....
  5. Roles of peripheral and central respiratory chemoreceptors in inbred rat strains
    MATTHEW ROBERT HODGES; Fiscal Year: 2013
    ..abstract_text> ..
  6. Neuron-Specific Candidate Gene Expression and Adolescent Vulnerability to Smoking
    BURT M contact SHARP; Fiscal Year: 2010
    ..Genetic factors play a large role in determining who will become a chronic smoker during adolescence. This research will identify these genetic factors, providing the foundation for new smoking prevention strategies. ..
  7. ESTOGENS, DIETARY ENERGY AND PITUITARY TUMORIGENESIS
    James Shull; Fiscal Year: 2002
    ....
  8. GENETIC COMPONENT OF AUTONOMIC DYSREFLEXIA
    Robert Blair; Fiscal Year: 2000
    ..Successful completion of these aims will provide new information indicating that there may be genes that predict the magnitude of autonomic dysreflexia following spinal cord injury. ..
  9. BRAIN PEPTIDE AND AMINE TRANSMITTERS IN NEW STRAINS
    EDITH HENDLEY; Fiscal Year: 1993
    ....
  10. Generation of Molecularly Defined Inbred Rat Mutants
    COLIN BISHOP; Fiscal Year: 2006
    ..Rats with gene trap transposon jumps into known or predicted genes, or other areas of interest, in the genome can be expanded for study or cryopreserved for distribution. ..
  11. MOLEC GENETIC & BIOCHEM INVESTIGATION OF THIAMINE TRANS
    CHARLES SINGLETON; Fiscal Year: 2000
    ..These experiments will be done on outbred and inbred rat strains, the latter of which are differentially susceptible to TD or show different alcohol drinking preferences. ..
  12. Gene-Environment Interactions and Stroke Susceptibility
    Myriam Fornage; Fiscal Year: 2004
    ..We will also identify and characterize DNA variation in a panel of selected stroke-candidate human genes and test whether variation in these genes is associated with risk of developing a stroke in the ARIC sample. ..
  13. INDUCTION AND ANALYSIS OF PROSTATE CANCER
    James Norris; Fiscal Year: 2001
    ....
  14. VIRAL INDUCED ALTERATIONS IN POSTNATAL PULMONARY GROWTH
    William Castleman; Fiscal Year: 1992
    ....
  15. TOLERANCE IN EXPERIMENTAL KIDNEY TRANSPLANTATION
    Daniel Salomon; Fiscal Year: 1992
    ..These new reagents will then be used to selectively manipulate the immune responses of transplanted animals in order to actively determine the roles of cyclosporine and suppressor induction circuits in transplantation tolerance...
  16. Amphetamine Sensitization: Role of Dopamine Transporters
    JOSHUA GULLEY; Fiscal Year: 2003
    ..These experiments will help elucidate the role of the DAT in behavioral sensitization and further our understanding of the neuroadaptations associated with repeated drug intake. ..
  17. ETHANOL PREFERENCE AND TASTE AVERSION LEARNING
    Dale Cannon; Fiscal Year: 1991
    ..Further, the relationship between EtOH preference and effectiveness of EtOH as a conditioned and unconditioned stimulus will be studied. Also investigated will be the relationship between drinking pattern and EtOH preference...
  18. Genetic Analysis of Vascular Aging
    Steven Miller; Fiscal Year: 2003
    ..abstract_text> ..
  19. GENETIC FACTORS AND SUPPRESSION OF MAMMARY CANCER
    John Isaacs; Fiscal Year: 1993
    ..Attempts will be made to clone the c-DNA corresponding to this MC suppressor gene...
  20. HEMOPHILUS INFLUENZAE TYPE B INFECTIONS
    Carl Norden; Fiscal Year: 1980
    ..influenzae type b. We are also examining the genetics of the immune response and of susceptibility to infection with H. influenzae type b in inbred strains of rats. ..
  21. ALCOHOL EXPOSURE EFFECTS: GENETIC BASIC
    David Blizard; Fiscal Year: 2006
    ..Overall, these studies will establish a mouse model for the study of genetic factors and sex as they influence individual differences in response to ethanol exposure during adolescence and early adult life. ..
  22. Gene expression associated with the CNS reinforcing act*
    ZACHARY RODD HENRICKS; Fiscal Year: 2003
    ..The results of the proposed project will provide valuable information on neuronal systems and receptors within the extended amygdala involved in mediating the rewarding properties of alcohol. ..
  23. PKC Signaling in cAMP-Induced Pulmonary Vasodilation
    SCOTT BARMAN; Fiscal Year: 2010
    ..Progress of these studies will provide important knowledge towards the development of novel therapeutic agents that will help reduce the morbidity and mortality associated with pulmonary hypertension. ..
  24. PARKINSON DISEASE COLLABORATIVE STUDY OF GENETIC LINKAGE
    Tatiana M Foroud; Fiscal Year: 2010
    ..2. Study the role of parkin mutations in Parkinson's disease. 3. Perform molecular studies to identify PD susceptibility genes. 4. Evaluate putative PD susceptibility genes in a case-control sample. ..
  25. Fluorescence Sensor Probe for Transcutaneous Glucose Sensing
    Ralph Ballerstadt; Fiscal Year: 2008
    ..The overall result will be a healthier life for people with diabetes and lower medical costs for diabetes care for the society. [unreadable] [unreadable] [unreadable]..
  26. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2002
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  27. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  28. EFFECTS OF ACID ON BONE
    David A Bushinsky; Fiscal Year: 2010
    ..The current proposal is aimed at understanding the first steps by which acid is detected by bone cells. Understanding the process by which the bone detects and neutralizes the acid can lead to an improvement in bone health. ..
  29. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  30. GENETIC ANALYSIS OF HIP FRAGILITY
    Tatiana M Foroud; Fiscal Year: 2010
    ..Our goal is to find genetic causes for bone weakening conditions like osteoporosis so better treatments can be developed. ..
  31. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  32. PD GWAS Consortium
    Tatiana M Foroud; Fiscal Year: 2010
    ....
  33. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2001
    ..abstract_text> ..
  34. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2009
    ..This project will examine bioeffects in cells and tissues and show how to safely use ultrasound contrast agents in diagnostic imaging. ..
  35. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  36. Identification of Novel Biomarkers in HD
    Tatiana Foroud; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  37. 5-Day Fiber-Coupled Sensor Interstitial Glucose
    Ralph Ballerstadt; Fiscal Year: 2006
    ..We believe the proposed sensor can provide a solution for short-term (3-5 days) continuous monitoring that will be accurate, reliable, and convenient for patient use. [unreadable] [unreadable] [unreadable]..
  38. Longitudinal Studies Among At-Risk HD Gene Carriers
    Tatiana Foroud; Fiscal Year: 2006
    ..abstract_text> ..
  39. A Cross-Cultural Longitudinal Assessment of FASD (U24)
    Tatiana Foroud; Fiscal Year: 2005
    ..abstract_text> ..
  40. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  41. Genetic Etilogy of Renal Agenesis in the ACI Rat
    James Shull; Fiscal Year: 2006
    ..Upon completion of these Aims, we will better understand the genetic bases of renal agenesis in the ACI rat and will be able to assess the relevance of this animal model to renal agenesis in humans. ..
  42. Nanoparticle-Based Optical Sensor for Glucose Monitoring
    Ralph Ballerstadt; Fiscal Year: 2006
    ..abstract_text> ..
  43. GENES FOR ALCOHOLISM SUSCEPTIBILITY
    Tatiana Foroud; Fiscal Year: 2003
    ..These studies will result in more sophisticated genetic analyses of alcoholism related data, as well as the development of optimum sampling designs for more efficient gene identification. ..
  44. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2003
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  45. Aerobic Running Capacity QTL's and Cardiac Performance
    GEORGE CICILA; Fiscal Year: 2005
    ..e., the COP and DA strains. Differentially-expressed genes that map near aerobic running capacity QTLs will be superior candidates for the gene(s) responsible for specific aerobic running capacity QTL. ..
  46. MOLECULAR CHARACTERIZATION OF THE JCPK/BPK LOCUS
    ELIZABETH BRYDA; Fiscal Year: 2003
    ..The completion of this proposal will greatly enhance our understanding of the role and regulation of cPLA2 in cell injury. ..
  47. Neuropeptide Modulation of Alcohol Drinking
    Nancy Elder; Fiscal Year: 2007
    ..The overall hypothesis is that manipulations aimed at increasing NPY activity may be particularly effective treatments when an organism has a history of repeated withdrawal and relapse. [unreadable] [unreadable] [unreadable]..
  48. Multi-photon microscope for the Indiana Center for Biological Microscopy
    Kenneth Dunn; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  49. BLOOD PRESSURE CANDIDATE GENE SCREENING--A NEW PARADIGM
    GEORGE CICILA; Fiscal Year: 2001
    ..This new approach should accelerate the identification of strong candidate genes for particular BP QTL and, potentially, of new blood pressure regulatory mechanisms. ..
  50. Identifying Chromosome 3 Blood Pressure QTL Candidates
    GEORGE CICILA; Fiscal Year: 2006
    ..Differentially-expressed genes that map in the QTL-containing region (identified in SPECIFIC AIM 1) will be superior candidate genes for that specific blood pressure QTL. ..
  51. 31P/1H MRI Measurement of Bone Mineralization
    Yaotang Wu; Fiscal Year: 2008
    ..abstract_text> ..
  52. CRF2 Receptor Modulation of Colonic Response to Stress
    MILLION MULUGETA; Fiscal Year: 2006
    ..abstract_text> ..
  53. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  54. Estrogen, ACE2 and Salt-Sensitivity
    Mark Chappell; Fiscal Year: 2008
    ..Lewis strain. ..
  55. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2007
    ..Through these three aims, we intend to isolate loci involved in ethanol preference, identify candidate genes for these loci in mice, and specify their human orthologs. ..
  56. Age and Cognition in a Mouse Model of Down Syndrome
    GALEN WENGER; Fiscal Year: 2009
    ..abstract_text> ..
  57. Sex Diffrerences in Opioid Antinociception
    Andrew Barrett; Fiscal Year: 2003
    ....
  58. Epigenetics of fetal alcohol syndrome
    Feng Zhou; Fiscal Year: 2009
    ..The effect of these epigenetic key genes will be confirmed in the in vivo model exposed to alcohol vapor chamber with alcohol exposure pattern and paradigms similar to the whole embryonic culture. ..
  59. Manganese-enhanced MRI Studies of Retinal Neovascularization
    BRUCE BERKOWITZ; Fiscal Year: 2008
    ..The novel methods in this application will also contribute to the advancement of functional MRI for the study of retinal diseases. [unreadable] [unreadable] [unreadable]..
  60. FACILITATED UPTAKE OF LONG CHAIN FATTY ACIDS IN OBESITY
    PAUL BERK; Fiscal Year: 2008
    ..Since tissue-specific up-regulation of LCFFA uptake characterizes obesity, understanding the regulatory mechanisms may have therapeutic implications. ..
  61. Sleep and fatigue during renal disease in mice
    LINDA TOTH; Fiscal Year: 2008
    ..Achieving this ambitious goal is feasible given the experience of my laboratory in surveying sleep phenotypes in other studies involving large numbers of mice. [unreadable] [unreadable]..
  62. CONFERENCE ON MAGNETIC RESONANCE IN BIOLOGICAL SYSTEMS
    Chien Ho; Fiscal Year: 2004
    ..S. members of the International Advisory Committee for the meeting. Particular emphasis will be placed on facilitating participation of minority and women scientists. ..