phytophthora

Summary

Summary: A genus of destructive parasitic algae in the family Pythiaceae, order Peronosporales, affecting numerous fruit, vegetable, and other crops. Differentiation of zoospores usually takes place in the sporangium and no vesicle is formed.

Top Publications

  1. pmc EST mining and functional expression assays identify extracellular effector proteins from the plant pathogen Phytophthora
    Trudy A Torto
    Department of Plant Pathology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, Ohio 44691, USA
    Genome Res 13:1675-85. 2003
  2. pmc An ancestral oomycete locus contains late blight avirulence gene Avr3a, encoding a protein that is recognized in the host cytoplasm
    Miles R Armstrong
    Plant Pathogen Interactions Programme, Scottish Crop Research Institute, Invergowrie, DD2 5DA Dundee, UK
    Proc Natl Acad Sci U S A 102:7766-71. 2005
  3. ncbi Genome evolution following host jumps in the Irish potato famine pathogen lineage
    Sylvain Raffaele
    The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK
    Science 330:1540-3. 2010
  4. pmc RXLR-mediated entry of Phytophthora sojae effector Avr1b into soybean cells does not require pathogen-encoded machinery
    Daolong Dou
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Plant Cell 20:1930-47. 2008
  5. pmc Conserved C-terminal motifs required for avirulence and suppression of cell death by Phytophthora sojae effector Avr1b
    Daolong Dou
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Plant Cell 20:1118-33. 2008
  6. ncbi The R1 gene for potato resistance to late blight (Phytophthora infestans) belongs to the leucine zipper/NBS/LRR class of plant resistance genes
    Agim Ballvora
    Max Planck Institut fur Zuchtungsforschung, Carl von Linne Weg 10, 50829 Köln, Germany
    Plant J 30:361-71. 2002
  7. ncbi Differential induction of two potato genes, Stprx2 and StNAC, in response to infection by Phytophthora infestans and to wounding
    M Collinge
    Friedrich Miescher Institute, Basle, Switzerland
    Plant Mol Biol 46:521-9. 2001
  8. ncbi An ancient R gene from the wild potato species Solanum bulbocastanum confers broad-spectrum resistance to Phytophthora infestans in cultivated potato and tomato
    Edwin van der Vossen
    Plant Research International BV, PO Box 16, 6700 AA Wageningen, The Netherlands
    Plant J 36:867-82. 2003
  9. pmc Analyses of genome architecture and gene expression reveal novel candidate virulence factors in the secretome of Phytophthora infestans
    Sylvain Raffaele
    The Sainsbury Laboratory, John Innes Centre, Norwich NR4 7UH, UK
    BMC Genomics 11:637. 2010
  10. ncbi The Avr1b locus of Phytophthora sojae encodes an elicitor and a regulator required for avirulence on soybean plants carrying resistance gene Rps1b
    Weixing Shan
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    Mol Plant Microbe Interact 17:394-403. 2004

Detail Information

Publications315 found, 100 shown here

  1. pmc EST mining and functional expression assays identify extracellular effector proteins from the plant pathogen Phytophthora
    Trudy A Torto
    Department of Plant Pathology, The Ohio State University, Ohio Agricultural Research and Development Center, Wooster, Ohio 44691, USA
    Genome Res 13:1675-85. 2003
    ..proteins from EST data sets, was developed and applied to 2147 ESTs from the oomycete plant pathogen Phytophthora infestans. The program identified 261 ESTs (12...
  2. pmc An ancestral oomycete locus contains late blight avirulence gene Avr3a, encoding a protein that is recognized in the host cytoplasm
    Miles R Armstrong
    Plant Pathogen Interactions Programme, Scottish Crop Research Institute, Invergowrie, DD2 5DA Dundee, UK
    Proc Natl Acad Sci U S A 102:7766-71. 2005
    The oomycete Phytophthora infestans causes late blight, the potato disease that precipitated the Irish famines in 1846 and 1847...
  3. ncbi Genome evolution following host jumps in the Irish potato famine pathogen lineage
    Sylvain Raffaele
    The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK
    Science 330:1540-3. 2010
    Many plant pathogens, including those in the lineage of the Irish potato famine organism Phytophthora infestans, evolve by host jumps followed by specialization. However, how host jumps affect genome evolution remains largely unknown...
  4. pmc RXLR-mediated entry of Phytophthora sojae effector Avr1b into soybean cells does not require pathogen-encoded machinery
    Daolong Dou
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Plant Cell 20:1930-47. 2008
    ..Using the effector protein Avr1b of Phytophthora sojae, an oomycete pathogen of soybean (Glycine max), we show that a pair of sequence motifs, RXLR and dEER, ..
  5. pmc Conserved C-terminal motifs required for avirulence and suppression of cell death by Phytophthora sojae effector Avr1b
    Daolong Dou
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Plant Cell 20:1118-33. 2008
    ..Here, we show that the Phytophthora sojae effector protein Avr1b can contribute positively to virulence and can suppress programmed cell death (PCD)..
  6. ncbi The R1 gene for potato resistance to late blight (Phytophthora infestans) belongs to the leucine zipper/NBS/LRR class of plant resistance genes
    Agim Ballvora
    Max Planck Institut fur Zuchtungsforschung, Carl von Linne Weg 10, 50829 Köln, Germany
    Plant J 30:361-71. 2002
    Late blight caused by the oomycete Phytophthora infestans is the most destructive disease in potato cultivation worldwide. New, more virulent P...
  7. ncbi Differential induction of two potato genes, Stprx2 and StNAC, in response to infection by Phytophthora infestans and to wounding
    M Collinge
    Friedrich Miescher Institute, Basle, Switzerland
    Plant Mol Biol 46:521-9. 2001
    To find out more about the interaction between potato and Phytophthora infestans at the molecular level, we screened for genes induced early after infection using mRNA differential display...
  8. ncbi An ancient R gene from the wild potato species Solanum bulbocastanum confers broad-spectrum resistance to Phytophthora infestans in cultivated potato and tomato
    Edwin van der Vossen
    Plant Research International BV, PO Box 16, 6700 AA Wageningen, The Netherlands
    Plant J 36:867-82. 2003
    Late blight, caused by the oomycete pathogen Phytophthora infestans, is the most devastating disease for potato cultivation...
  9. pmc Analyses of genome architecture and gene expression reveal novel candidate virulence factors in the secretome of Phytophthora infestans
    Sylvain Raffaele
    The Sainsbury Laboratory, John Innes Centre, Norwich NR4 7UH, UK
    BMC Genomics 11:637. 2010
    b>Phytophthora infestans is the most devastating pathogen of potato and a model organism for the oomycetes. It exhibits high evolutionary potential and rapidly adapts to host plants. The P...
  10. ncbi The Avr1b locus of Phytophthora sojae encodes an elicitor and a regulator required for avirulence on soybean plants carrying resistance gene Rps1b
    Weixing Shan
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    Mol Plant Microbe Interact 17:394-403. 2004
    ..to clone a locus containing two genes, Avr1b-1 and Avr1b-2, required for avirulence of the oomycete pathogen Phytophthora sojae (Kaufmann & Gerdemann) on soybean plants carrying resistance gene Rps1b...
  11. ncbi Phytophthora infestans: the plant (and R gene) destroyer
    William Fry
    Cornell University, Department of Plant Pathology, Ithaca, NY 14853, USA
    Mol Plant Pathol 9:385-402. 2008
    b>Phytophthora infestans remains a problem to production agriculture. Historically there have been many controversies concerning its biology and pathogenicity, some of which remain today...
  12. ncbi Phytophthora genome sequences uncover evolutionary origins and mechanisms of pathogenesis
    Brett M Tyler
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Science 313:1261-6. 2006
    Draft genome sequences have been determined for the soybean pathogen Phytophthora sojae and the sudden oak death pathogen Phytophthora ramorum...
  13. ncbi Digital gene expression profiling of the Phytophthora sojae transcriptome
    Wenwu Ye
    Department of Plant Pathology, Nanjing Agricultural University, Nanjing, China
    Mol Plant Microbe Interact 24:1530-9. 2011
    The transcriptome of the oomycete plant pathogen Phytophthora sojae was profiled at ten different developmental and infection stages based on a 3'-tag digital gene-expression protocol...
  14. pmc Core promoter structure in the oomycete Phytophthora infestans
    Adele McLeod
    Department of Plant Pathology, Cornell University, Ithaca, New York 14853, USA
    Eukaryot Cell 3:91-9. 2004
    We have investigated the core promoter structure of the oomycete Phytophthora infestans. The transcriptional start sites (TSS) of three previously characterized P...
  15. pmc Genome sequencing and mapping reveal loss of heterozygosity as a mechanism for rapid adaptation in the vegetable pathogen Phytophthora capsici
    Kurt H Lamour
    University of Tennessee, Knoxville, TN, USA
    Mol Plant Microbe Interact 25:1350-60. 2012
    The oomycete vegetable pathogen Phytophthora capsici has shown remarkable adaptation to fungicides and new hosts. Like other members of this destructive genus, P...
  16. pmc Transcriptional programming and functional interactions within the Phytophthora sojae RXLR effector repertoire
    Qunqing Wang
    Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China
    Plant Cell 23:2064-86. 2011
    The genome of the soybean pathogen Phytophthora sojae contains nearly 400 genes encoding candidate effector proteins carrying the host cell entry motif RXLR-dEER...
  17. ncbi The Rpi-blb2 gene from Solanum bulbocastanum is an Mi-1 gene homolog conferring broad-spectrum late blight resistance in potato
    Edwin A G van der Vossen
    Plant Research International BV, PO Box 16, 6700 AA Wageningen, The Netherlands
    Plant J 44:208-22. 2005
    The necessity to develop potato and tomato crops that possess durable resistance against the oomycete pathogen Phytophthora infestans is increasing as more virulent, crop-specialized and pesticide resistant strains of the pathogen are ..
  18. ncbi The oomycete broad-host-range pathogen Phytophthora capsici
    Kurt H Lamour
    Department of Entomology and Plant Pathology, University of Tennessee, Knoxville, TN 37996, USA
    Mol Plant Pathol 13:329-37. 2012
    b>Phytophthora capsici is a highly dynamic and destructive pathogen of vegetables. It attacks all cucurbits, pepper, tomato and eggplant, and, more recently, snap and lima beans...
  19. ncbi High affinity recognition of a Phytophthora protein by Arabidopsis via an RGD motif
    V Senchou
    Surfaces Cellulaires et Signalisation chez les Végétaux, UMR 5546 CNRS Université Paul Sabatier, 31326 Castanet Tolosan Cedex, France
    Cell Mol Life Sci 61:502-9. 2004
    ..RGD peptides, but also by the IPI-O protein, an RGD-containing protein secreted by the oomycete plant pathogen Phytophthora infestans...
  20. ncbi Phylogenetic relationships of Phytophthora andina, a new species from the highlands of Ecuador that is closely related to the Irish potato famine pathogen Phytophthora infestans
    Luis Gómez-Alpizar
    Agronomic Research Center, Box 2060, University of Costa Rica, San Pedro, Montes de Oca, Costa Rica
    Mycologia 100:590-602. 2008
    Phylogenetic relationships of Phytophthora infestans sensu lato in the Andean highlands of South America were examined...
  21. ncbi A multi-locus phylogeny for Phytophthora utilizing markers derived from complete genome sequences
    Jaime E Blair
    Department of Plant Pathology, The Pennsylvania State University, University Park, PA 16802, USA
    Fungal Genet Biol 45:266-77. 2008
    b>Phytophthora species are devastating plant pathogens in both agricultural and natural environments...
  22. pmc The Phytophthora sojae avirulence locus Avr3c encodes a multi-copy RXLR effector with sequence polymorphisms among pathogen strains
    Suomeng Dong
    Agriculture and Agri Food Canada, London, Ontario, Canada
    PLoS ONE 4:e5556. 2009
    Root and stem rot disease of soybean is caused by the oomycete Phytophthora sojae. The avirulence (Avr) genes of P. sojae control race-cultivar compatibility. In this study, we identify the P...
  23. ncbi A molecular phylogeny of Phytophthora and related oomycetes
    D E Cooke
    Scottish Crop Research Institute, Invergowrie, Dundee, United Kingdom
    Fungal Genet Biol 30:17-32. 2000
    Phylogenetic relationships among 50 Phytophthora species and between Phytophthora and other oomycetes were examined on the basis of the ITS sequences of genomic rDNA...
  24. ncbi The genus Phytophthora anno 2012
    Laurens P N M Kroon
    Bejo Zaden B V, Trambaan 2A, 1749 CZ, Warmenhuizen, The Netherlands
    Phytopathology 102:348-64. 2012
    Plant diseases caused by Phytophthora species will remain an ever increasing threat to agriculture and natural ecosystems...
  25. ncbi Gene expression profiling during asexual development of the late blight pathogen Phytophthora infestans reveals a highly dynamic transcriptome
    Howard S Judelson
    Department of Plant Pathology and Microbiology, University of California, Riverside 92521, USA
    Mol Plant Microbe Interact 21:433-47. 2008
    Much of the pathogenic success of Phytophthora infestans, the potato and tomato late blight agent, relies on its ability to generate from mycelia large amounts of sporangia, which release zoospores that encyst and form infection ..
  26. pmc EST sequencing and gene expression profiling of defence-related genes from Persea americana infected with Phytophthora cinnamomi
    Waheed Mahomed
    Forestry and Agricultural Biotechnology Institute FABI, University of Pretoria, Pretoria 0002, South Africa
    BMC Plant Biol 11:167. 2011
    ..The most serious pathogen affecting avocado production is Phytophthora cinnamomi which causes Phytophthora root rot (PRR). Root pathogens such as P...
  27. ncbi Forest type influences transmission of Phytophthora ramorum in California oak woodlands
    Jennifer M Davidson
    Pacific Southwest Research Station, United States Department of Agriculture Forest Service, P O Box 245, Berkeley, CA 94701, USA
    Phytopathology 101:492-501. 2011
    The transmission ecology of Phytophthora ramorum from bay laurel (Umbellularia californica) leaves was compared between mixed-evergreen and redwood forest types throughout winter and summer disease cycles in central, coastal California...
  28. pmc Phenotypic diversification is associated with host-induced transposon derepression in the sudden oak death pathogen Phytophthora ramorum
    Takao Kasuga
    Crops Pathology and Genetics Research Unit, United States Department of Agriculture Agricultural Research Service, Davis, California, United States of America
    PLoS ONE 7:e34728. 2012
    The oomycete pathogen Phytophthora ramorum is responsible for sudden oak death (SOD) in California coastal forests. P. ramorum is a generalist pathogen with over 100 known host species. Three or four closely related genotypes of P...
  29. pmc Phage-displayed peptides as developmental agonists for Phytophthora capsici zoospores
    Sharon L Bishop-Hurley
    Department of Plant Microbiology and Patholog, University of Missouri, Columbia, MO 65211, USA
    Appl Environ Microbiol 68:3315-20. 2002
    As part of its pathogenic life cycle, Phytophthora capsici disperses to plants through a motile zoospore stage. Molecules on the zoospore surface are involved in reception of environmental signals that direct preinfection behavior...
  30. ncbi Soybean phytophthora resistance gene Rps8 maps closely to the Rps3 region
    D Sandhu
    Department of Agronomy, Iowa State University, Ames, IA 50011 1010, USA
    J Hered 96:536-41. 2005
    Root and stem rot is one of the major diseases of soybean. It is caused by the oomycete pathogen Phytophthora sojae. A series of resistance genes (Rps) have been providing soybean with reasonable protection against this pathogen...
  31. pmc Activation of zoosporogenesis-specific genes in Phytophthora infestans involves a 7-nucleotide promoter motif and cold-induced membrane rigidity
    Shuji Tani
    Department of Plant Pathology, University of California, Riverside, CA 92521, USA
    Eukaryot Cell 5:745-52. 2006
    Infections of plants by the oomycete Phytophthora infestans typically result from zoospores, which develop from sporangia at cold temperatures...
  32. pmc The CAZyome of Phytophthora spp.: a comprehensive analysis of the gene complement coding for carbohydrate-active enzymes in species of the genus Phytophthora
    Manuel D Ospina-Giraldo
    Biology Department, Lafayette College, Easton, PA 18042, USA
    BMC Genomics 11:525. 2010
    ..In Phytophthora infestans, penetration of the plant cells occurs through a specialized hyphal structure called appressorium; ..
  33. ncbi The immediate activation of defense responses in Arabidopsis roots is not sufficient to prevent Phytophthora parasitica infection
    Agnès Attard
    Unité Mixte de Recherches Interactions Biotiques et Santé Végétale, INRA1301 CNRS6243 UNS, 400 Route des Chappes, F 06903 Sophia Antipolis, France
    New Phytol 187:449-60. 2010
    ..thaliana and Phytophthora parasitica. *Phytophthora parasitica uses appressoria to penetrate A. thaliana roots...
  34. ncbi Genetic characterization of the natural hybrid species Phytophthora alni as inferred from nuclear and mitochondrial DNA analyses
    Renaud Ioos
    Institut National de la Recherche Agronomique, UMR1136, Pathologie forestière, Champenoux, France
    Fungal Genet Biol 43:511-29. 2006
    The different subspecies of Phytophthora alni, P. alni subsp. alni (Paa), P. alni subsp. uniformis (Pau), and P. alni subsp. multiformis (Pam), are recent and widespread pathogens of alder in Europe...
  35. pmc Transcriptome of Aphanomyces euteiches: new oomycete putative pathogenicity factors and metabolic pathways
    Elodie Gaulin
    UMR 5546 Centre National de la Recherche Scientifique CNRS, Universite Paul Sabatier Toulouse III, Universite de Toulouse, Pole de Biotechnologie Vegetale, Castanet Tolosan, France
    PLoS ONE 3:e1723. 2008
    ..The genus Aphanomyces is phylogenically distinct from well-studied oomycetes such as Phytophthora sp., and contains species pathogenic on plants and aquatic animals...
  36. ncbi The chloroplast protein RPH1 plays a role in the immune response of Arabidopsis to Phytophthora brassicae
    Khaoula Belhaj
    Department of Biology, University of Fribourg, Fribourg, Switzerland
    Plant J 58:287-98. 2009
    ..We have identified the Arabidopsis mutant rph1 (resistance to Phytophthora 1), which is susceptible to the oomycete pathogen Phytophthora brassicae despite rapid induction of HR...
  37. ncbi Different domains of Phytophthora sojae effector Avr4/6 are recognized by soybean resistance genes Rps4 and Rps6
    Daolong Dou
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University Blacksburg 24061, USA
    Mol Plant Microbe Interact 23:425-35. 2010
    At least 12 avirulence genes have been genetically identified and mapped in Phytophthora sojae, an oomycete pathogen causing root and stem rot of soybean. Previously, the Avr4 and Avr6 genes of P...
  38. pmc Soybean root suberin: anatomical distribution, chemical composition, and relationship to partial resistance to Phytophthora sojae
    Raymond Thomas
    Environmental Stress Biology Group, Department of Biology, University of Western Ontario, London, Ontario, Canada
    Plant Physiol 144:299-311. 2007
    ..year millions of dollars of potential yield revenues are lost due to a root rot disease caused by the oomycete Phytophthora sojae (Kaufmann & Gerdemann)...
  39. pmc Two host cytoplasmic effectors are required for pathogenesis of Phytophthora sojae by suppression of host defenses
    Tingli Liu
    Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China
    Plant Physiol 155:490-501. 2011
    b>Phytophthora sojae encodes hundreds of putative host cytoplasmic effectors with conserved FLAK motifs following signal peptides, termed crinkling- and necrosis-inducing proteins (CRN) or Crinkler...
  40. pmc Copy number variation and transcriptional polymorphisms of Phytophthora sojae RXLR effector genes Avr1a and Avr3a
    Dinah Qutob
    Agriculture and Agri Food Canada, London, Ontario, Canada
    PLoS ONE 4:e5066. 2009
    ..Now, we have identified the Phytophthora sojae avirulence genes Avr1a and Avr3a and demonstrate how each of these Avr genes display copy number ..
  41. pmc A common toxin fold mediates microbial attack and plant defense
    Christian Ottmann
    Center for Plant Molecular Biology Plant Physiology, University of Tubingen, Tubingen, Germany
    Proc Natl Acad Sci U S A 106:10359-64. 2009
    ..Computational modeling of the 3-dimensional structure of NLPs from another oomycete, Phytophthora parasitica, and from the phytopathogenic bacterium, Pectobacterium carotovorum, revealed a high extent of fold ..
  42. ncbi A translocation signal for delivery of oomycete effector proteins into host plant cells
    Stephen C Whisson
    Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    Nature 450:115-8. 2007
    ..We use the Phytophthora infestans RXLR-EER-containing protein Avr3a as a reporter for translocation because it triggers RXLR-EER-..
  43. ncbi Towards an understanding of the nature of resistance to Phytophthora root rot in red raspberry
    J Graham
    Genetics Department, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, Scotland, UK
    Theor Appl Genet 123:585-601. 2011
    ..For marker-assisted breeding, the SSR marker Rub118b 110 bp allele from Latham was found in resistant germplasm but was not found in any of the susceptible germplasm tested...
  44. ncbi Optimization of transgene-mediated silencing in Phytophthora infestans and its association with small-interfering RNAs
    Audrey M V Ah-Fong
    Department of Plant Pathology and Microbiology, University of California, Riverside, CA 92521, USA
    Fungal Genet Biol 45:1197-205. 2008
    Methods for silencing genes in Phytophthora transformants have been demonstrated previously, but wide variation in effectiveness was reported in different studies...
  45. pmc A Phytophthora sojae G-protein alpha subunit is involved in chemotaxis to soybean isoflavones
    Chenlei Hua
    Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China
    Eukaryot Cell 7:2133-40. 2008
    For the soybean pathogen Phytophthora sojae, chemotaxis of zoospores to isoflavones is believed to be critical for recognition of the host and for initiating infection...
  46. ncbi BAC-derived markers converted from RFLP linked to Phytophthora capsici resistance in pepper (Capsicum annuum L.)
    Hyoun Joung Kim
    Department of Plant Science, Seoul National University, Seoul, 151 921, South Korea
    Theor Appl Genet 118:15-27. 2008
    b>Phytophthora capsici Leonian, an oomycete pathogen, is a serious problem in pepper worldwide. Its resistance in pepper is controlled by quantitative trait loci (QTL). To detect QTL associated with P...
  47. pmc Cellulose binding domains of a Phytophthora cell wall protein are novel pathogen-associated molecular patterns
    Elodie Gaulin
    Unite Mixte de Recherche 5546, Centre National de la Recherche Scientifique Université Paul Sabatier Toulouse III, Pole de Biotechnologie Vegetale, 31326 Castanet Tolosan, France
    Plant Cell 18:1766-77. 2006
    The cellulose binding elicitor lectin (CBEL) from Phytophthora parasitica nicotianae contains two cellulose binding domains (CBDs) belonging to the Carbohydrate Binding Module1 family, which is found almost exclusively in fungi...
  48. ncbi Endophytic bacterial flora in root and stem tissues of black pepper (Piper nigrum L.) genotype: isolation, identification and evaluation against Phytophthora capsici
    R Aravind
    Indian Institute of Spices Research, Calicut, Kerala, India
    Lett Appl Microbiol 48:58-64. 2009
    To isolate and identify black pepper (Piper nigrum L) associated endophytic bacteria antagonistic to Phytophthora capsici causing foot rot disease.
  49. ncbi Tagging quantitative trait loci for maturity-corrected late blight resistance in tetraploid potato with PCR-based candidate gene markers
    Christina Angelika Bormann
    Max Planck Institute for Plant Breeding Research, Carl von Linne Weg 10, D 50829 Cologne, Germany
    Mol Plant Microbe Interact 17:1126-38. 2004
    Late blight caused by the oomycete Phytophthora infestans is the economically most important and destructive disease in potato cultivation...
  50. pmc A gene expressed during sexual and asexual sporulation in Phytophthora infestans is a member of the Puf family of translational regulators
    Cristina Cvitanich
    Department of Plant Pathology, University of California, Riverside, California 92521, USA
    Eukaryot Cell 2:465-73. 2003
    A gene from Phytophthora infestans that was previously identified as being induced during the development of sexual spores was also found to be active during asexual sporulation. The gene, M90, was expressed as a 3...
  51. ncbi Sudden oak death: Phytophthora ramorum exhibits transatlantic differences
    Clive Brasier
    Mycol Res 107:258-9. 2003
  52. ncbi Isolation and in vitro and in vivo activity against Phytophthora capsici and Colletotrichum orbiculare of phenazine-1-carboxylic acid from Pseudomonas aeruginosa strain GC-B26
    Jung Yeop Lee
    Laboratory of Molecular Plant Pathology, College of Life and Environmental Sciences, Korea University, Seoul 136 701, Korea
    Pest Manag Sci 59:872-82. 2003
    ..The antibiotic G26A, active against Phytophthora capsici Leonian and Colletotrichum orbiculare (Berk & Mont) van Arx, was isolated from the culture ..
  53. ncbi Rapid detection of Phytophthora ramorum and P. kernoviae by two-minute DNA extraction followed by isothermal amplification and amplicon detection by generic lateral flow device
    J A Tomlinson
    The Food and Environmental Research Agency, Sand Hutton, York YO41 1LZ, United Kingdom
    Phytopathology 100:143-9. 2010
    ..The use of this method is demonstrated for the detection of Phytophthora ramorum, the causal agent of sudden oak death and dieback/leaf blight in a range of tree, shrub, and herbaceous ..
  54. ncbi Use of a secretion trap screen in pepper following Phytophthora capsici infection reveals novel functions of secreted plant proteins in modulating cell death
    Seon In Yeom
    Department of Plant Science, Seoul National University, Seoul, Republic of Korea
    Mol Plant Microbe Interact 24:671-84. 2011
    ..the role of secreted proteins, a yeast-based signal-sequence trap screening was conducted with the RNA from Phytophthora capsici-inoculated root of Capsicum annuum 'Criollo de Morelos 334' (CM334)...
  55. ncbi Pyramided QTL underlying tolerance to Phytophthora root rot in mega-environments from soybean cultivars 'Conrad' and 'Hefeng 25'
    Xiuping Li
    Soybean Research Institute, Key Laboratory of Soybean Biology in Chinese Ministry of Education, Northeast Agricultural University, 150030 Harbin, China
    Theor Appl Genet 121:651-8. 2010
    b>Phytophthora root rot (PRR) of soybean (Glycine max (L.) Merr.) is the second most important cause of yield loss by disease in North America, surpassed only by soybean cyst nematode (Wrather et al. in Can J Plant Pathol 23:115-121, 2001)...
  56. pmc New role for Cdc14 phosphatase: localization to basal bodies in the oomycete phytophthora and its evolutionary coinheritance with eukaryotic flagella
    Audrey M V Ah-Fong
    Department of Plant Pathology and Microbiology and Center for Plant Cell Biology, University of California Riverside, Riverside, California, United States of America
    PLoS ONE 6:e16725. 2011
    ..Here we reveal a distinctly new role for Cdc14 based on studies of the microbial eukaryote Phytophthora infestans, the Irish potato famine agent...
  57. ncbi Baseline sensitivity of natural population and resistance of mutants in Phytophthora capsici to zoxamide
    Yang Bi
    Department of Plant Pathology, China Agricultural University, Beijing, China
    Phytopathology 101:1104-11. 2011
    Laboratory experiments were conducted to determine the baseline sensitivity of Phytophthora capsici and its risk for developing resistance to zoxamide. In total, 158 P. capsici isolates were collected from China...
  58. ncbi Phytophthora ramorum: integrative research and management of an emerging pathogen in California and Oregon forests
    David M Rizzo
    Department of Plant Pathology, University of California, Davis, California 95616, USA
    Annu Rev Phytopathol 43:309-35. 2005
    b>Phytophthora ramorum, causal agent of sudden oak death, is an emerging plant pathogen first observed in North America associated with mortality of tanoak (Lithocarpus densiflorus) and coast live oak (Quercus agrifolia) in coastal forests ..
  59. ncbi Baseline sensitivity and resistance-risk assessment of Phytophthora capsici to iprovalicarb
    Xiao hong Lu
    Department of Plant Pathology, China Agricultural University, Beijing, China
    Phytopathology 100:1162-8. 2010
    Iprovalicarb has been used to control Phytophthora capsici, a devastating pathogen of many economically important crops. To evaluate the risk of fungicide resistance, 158 isolates of P...
  60. pmc Phytophthora sojae avirulence effector Avr3b is a secreted NADH and ADP-ribose pyrophosphorylase that modulates plant immunity
    Suomeng Dong
    College of Plant Protection, Nanjing Agricultural University, Nanjing, China
    PLoS Pathog 7:e1002353. 2011
    ..Here, we combined bioinformatics and genetics to identify Avr3b, a new Avr gene from Phytophthora sojae, an oomycete pathogen that causes soybean root rot...
  61. ncbi Effect of temperature and moisture period on infection of Rhododendron 'Cunningham's White' by Phytophthora ramorum
    Paul W Tooley
    United States Department of Agriculture Agricultural Research Service, Foreign Disease Weed Science Research Unit, 1301 Ditto Avenue, Ft Detrick, MD 21702 5023, USA
    Phytopathology 99:1045-52. 2009
    We investigated the temperature and moisture conditions that allow Phytophthora ramorum to infect Rhododendron 'Cunningham's White'. Most experiments were performed with a single P. ramorum isolate from the NA1 clonal lineage...
  62. pmc GPR11, a putative seven-transmembrane G protein-coupled receptor, controls zoospore development and virulence of Phytophthora sojae
    Yonglin Wang
    Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China
    Eukaryot Cell 9:242-50. 2010
    ..To understand signaling mechanisms mediated by GPCRs in Phytophthora sojae, we identified and characterized the PsGPR11 gene, which encodes a putative seven-transmembrane GPCR...
  63. pmc Architecture of the sporulation-specific Cdc14 promoter from the oomycete Phytophthora infestans
    Audrey M V Ah-Fong
    Department of Plant Pathology and Microbiology, University of California, Riverside, CA 92521, USA
    Eukaryot Cell 6:2222-30. 2007
    The Cdc14 gene of Phytophthora infestans is transcribed specifically during sporulation, with no mRNA detectable in vegetative hyphae, and is required for sporangium development...
  64. pmc A Myb transcription factor of Phytophthora sojae, regulated by MAP kinase PsSAK1, is required for zoospore development
    Meng Zhang
    Key Laboratory of Integrated Management of Crop Diseases and Pests, College of Plant Protection, Nanjing Agricultural University, Ministry of Education, Nanjing, China
    PLoS ONE 7:e40246. 2012
    PsSAK1, a mitogen-activated protein (MAP) kinase from Phytophthora sojae, plays an important role in host infection and zoospore viability. However, the downstream mechanism of PsSAK1 remains unclear...
  65. ncbi Characterization of a Phytophthora infestans gene involved in vesicle transport
    Y Chen
    Department of Biochemistry, Microbiology and Molecular Biology, University of Maine, Orono 04469 5735, USA
    Gene 181:89-94. 1996
    ..We report here the characterization of a gene from Phytophthora infestans encoding a deduced amino acid (aa) sequence belonging to the Ypt class of monomeric GTP-binding ..
  66. ncbi In vitro and in vivo antimicrobial activity of Xenorhabdus bovienii YL002 against Phytophthora capsici and Botrytis cinerea
    X L Fang
    Research and Development Center of Biorational Pesticides, Northwest A and F University, Yangling Shaanxi, China
    J Appl Microbiol 111:145-54. 2011
    ..plant pathogenic fungi and oomycete in vitro and the efficiency of this strain to reduce the in vivo incidence of grey mould rot on tomato plants caused by Botrytis cinerea and leaf scorch on pepper plants caused by Phytophthora capsici.
  67. pmc Sequence variants of the Phytophthora sojae RXLR effector Avr3a/5 are differentially recognized by Rps3a and Rps5 in soybean
    Suomeng Dong
    Agriculture and Agri Food Canada, London, Ontario, Canada
    PLoS ONE 6:e20172. 2011
    The perception of Phytophthora sojae avirulence (Avr) gene products by corresponding soybean resistance (Rps) gene products causes effector triggered immunity. Past studies have shown that the Avr3a and Avr5 genes of P...
  68. ncbi Sources of inoculum for Phytophthora ramorum in a redwood forest
    J M Davidson
    Pacific Southwest Research Station, USDA Forest Device, Berkeley, CA 94701, USA
    Phytopathology 98:860-6. 2008
    ABSTRACT Sources of inoculum were investigated for dominant hosts of Phytophthora ramorum in a redwood forest...
  69. ncbi Molecular comparison of natural hybrids of Phytophthora nicotianae and P. cactorum infecting loquat trees in Peru and Taiwan
    O P Hurtado-Gonzales
    Entomology and Plant Pathology Department, University of Tennessee, Knoxville, Tennessee 37996, USA
    Mycologia 101:496-502. 2009
    Natural Phytophthora hybrids (P. nicotianae x P...
  70. ncbi Early detection of emerging forest disease using dispersal estimation and ecological niche modeling
    Ross K Meentemeyer
    Department of Geography and Earth Sciences, University of North Carolina, 9201 University City Boulevard, Charlotte, North Carolina 28223, USA
    Ecol Appl 18:377-90. 2008
    ..force of infection predict invasion of Phytophthora ramorum, the causal agent of the emerging infectious tree disease sudden oak death...
  71. pmc PCR amplification of ribosomal DNA for species identification in the plant pathogen genus Phytophthora
    J B Ristaino
    Department of Plant Pathology, North Carolina State University, Raleigh 27695, USA
    Appl Environ Microbiol 64:948-54. 1998
    ..of the economically important species from each of the six taxonomic groups in the plant pathogen genus Phytophthora. This procedure involves amplification of the 5...
  72. ncbi Identification of QTLs related to cocoa resistance to three species of Phytophthora
    A M Risterucci
    CIRAD, Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement, UMR 1096, Avenue Agropolis, BP 5035, 34398, Montpellier Cedex 5, France
    Theor Appl Genet 108:168-74. 2003
    This study aimed to compare the genetic control of cacao resistance to three species of Phytophthora: Phytophthora palmivora, Phytophthora megakarya and Phytophthora capsici...
  73. ncbi Infection of Arabidopsis thaliana by Phytophthora parasitica and identification of variation in host specificity
    Yan Wang
    College of Plant Protection, Northwest A and F University, Yangling, Shaanxi 712100, China
    Mol Plant Pathol 12:187-201. 2011
    ..In this study, we established a new plant-oomycete pathosystem in which the broad host range pathogen Phytophthora parasitica was demonstrated to be capable of interacting compatibly with the model plant Arabidopsis thaliana...
  74. ncbi Cell cycle regulator Cdc14 is expressed during sporulation but not hyphal growth in the fungus-like oomycete Phytophthora infestans
    Audrey M V Ah Fong
    Department of Plant Pathology, University of California, Riverside, CA 92521, USA
    Mol Microbiol 50:487-94. 2003
    ..Here we describe a homologue (piCdc14) from the oomycete Phytophthora infestans, a primitive eukaryote lacking a classical cell cycle...
  75. ncbi Mapping QTL for yield components, vigor, and resistance to Phytophthora palmivora in Theobroma cacao L
    D Clement
    Centre de coopération internationale en recherche pour le développement CIRAD, TA 80 02, Avenue d Agropolis, Montpellier 34398 CEDEX 5, France
    Genome 46:204-12. 2003
    ..Regions of the genome involved in yield, vigor, and resistance to Phytophthora palmivora were identified...
  76. ncbi A cDNA-AFLP based strategy to identify transcripts associated with avirulence in Phytophthora infestans
    Jun Guo
    Plant Sciences Group, Laboratory of Phytopathology, Wageningen University, Binnenhaven 5, NL 6709 PD Wageningen, The Netherlands
    Fungal Genet Biol 43:111-23. 2006
    ..Here, cDNA-AFLP was used to identify transcripts in a segregating F1 population of Phytophthora infestans, the oomycete pathogen that causes late blight...
  77. ncbi Structure of the glucanase inhibitor protein (GIP) family from phytophthora species suggests coevolution with plant endo-beta-1,3-glucanases
    Cynthia M B Damasceno
    Department of Plant Biology, Cornell University, Ithaca, NY 14853, U S A
    Mol Plant Microbe Interact 21:820-30. 2008
    During invasion of their plant hosts, species of the oomycete genus Phytophthora secrete glucanase inhibitor proteins (GIPs) into the plant apoplast, which bind and inhibit the activity of plant extracellular endo-beta-1,3-glucanases (..
  78. pmc Effector genomics accelerates discovery and functional profiling of potato disease resistance and phytophthora infestans avirulence genes
    Vivianne G A A Vleeshouwers
    Wageningen UR Plant Breeding, Wageningen, The Netherlands
    PLoS ONE 3:e2875. 2008
    ..food crop yet it continues to endure late blight, a devastating disease caused by the Irish famine pathogen Phytophthora infestans...
  79. ncbi The CBEL glycoprotein of Phytophthora parasitica var-nicotianae is involved in cell wall deposition and adhesion to cellulosic substrates
    Elodie Gaulin
    UMR 5546 UPS CNRS, Pole de Biotechnologie Vegetale, 24 Chemin de Borde Rouge, BP17, Auzeville, F 31326 Castanet Tolosan, France
    J Cell Sci 115:4565-75. 2002
    The cell wall of the oomycete plant pathogen Phytophthora parasitica var. nicotianae contains a protein called CBEL that shows cellulose-binding (CB), elicitor (E) of defense in plants and lectin-like (L) activities...
  80. ncbi Evolution of the cutinase gene family: evidence for lateral gene transfer of a candidate Phytophthora virulence factor
    Lassaad Belbahri
    Laboratory of Applied Genetics, University of Applied Sciences of Western Switzerland, Jussy, Switzerland
    Gene 408:1-8. 2008
    ..gene transfer of cutinases -- well documented virulence factors in fungi -- between eukaryotic plant pathogens Phytophthora species and prokaryotic bacterial lineages...
  81. ncbi A proteomics study of in vitro cyst germination and appressoria formation in Phytophthora infestans
    Tine Ebstrup
    Biosystems Department, Risoe National Laboratory, Roskilde, Denmark
    Proteomics 5:2839-48. 2005
    A proteomics study using two-dimensional gel electrophoresis (2-DE) and mass spectrometry was performed on Phytophthora infestans. Proteins from cysts, germinated cysts and appressoria grown in vitro were isolated and separated by 2-DE...
  82. pmc RXLR effector reservoir in two Phytophthora species is dominated by a single rapidly evolving superfamily with more than 700 members
    Rays H Y Jiang
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Proc Natl Acad Sci U S A 105:4874-9. 2008
    ..A number of effectors identified in plant pathogenic Phytophthora species possess N-terminal motifs (RXLR-dEER) required for targeting these effectors into host cells...
  83. ncbi Plasmodium falciparum and Hyaloperonospora parasitica effector translocation motifs are functional in Phytophthora infestans
    Severine Grouffaud
    Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    Microbiology 154:3743-51. 2008
    The oomycete potato late blight pathogen, Phytophthora infestans, and the apicomplexan malaria parasite Plasmodium falciparum translocate effector proteins inside host cells, presumably to the benefit of the pathogen or parasite...
  84. ncbi Late blight resistance linkages in a novel cross of the wild potato species Solanum paucissectum (series Piurana)
    F G Villamon
    Vegetable Crops Research Unit, USDA, Agricultural Research Service, Department of Horticulture, University of Wisconsin, Madison, WI 53706 1590, USA
    Theor Appl Genet 111:1201-14. 2005
    The cultivated potato, Solanum tuberosum, is affected by a variety of diseases with late blight, caused by Phytophthora infestans, being the most severe...
  85. pmc Infection and genotype remodel the entire soybean transcriptome
    Lecong Zhou
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    BMC Genomics 10:49. 2009
    ..large-scale microarray experiment involving 72 biological replicates to analyze the response of soybean plants to infection by the pathogen Phytophthora sojae and to analyze transcriptional modulation as a result of genotypic variation.
  86. ncbi A gene encoding a protein elicitor of Phytophthora infestans is down-regulated during infection of potato
    S Kamoun
    Department of Phytopathology, Wageningen Agricultural University, The Netherlands
    Mol Plant Microbe Interact 10:13-20. 1997
    Most species of the genus Phytophthora produce 10-kDa extracellular protein elicitors, collectively termed elicitins...
  87. ncbi Disease resistance of Arabidopsis to Phytophthora brassicae is established by the sequential action of indole glucosinolates and camalexin
    Klaus Schlaeppi
    Department of Biology, University of Fribourg, Fribourg, Switzerland
    Plant J 62:840-51. 2010
    ..role of tryptophan-derived secondary metabolites in disease resistance of Arabidopsis to the oomycete pathogen Phytophthora brassicae...
  88. pmc The hidden duplication past of the plant pathogen Phytophthora and its consequences for infection
    Cindy Martens
    Department of Plant Systems Biology, VIB, Ghent, Belgium
    BMC Genomics 11:353. 2010
    Oomycetes of the genus Phytophthora are pathogens that infect a wide range of plant species. For dicot hosts such as tomato, potato and soybean, Phytophthora is even the most important pathogen...
  89. pmc Transgene-induced silencing of the zoosporogenesis-specific NIFC gene cluster of Phytophthora infestans involves chromatin alterations
    Howard S Judelson
    Department of Plant Pathology and Microbiology, University of California, Riverside, Riverside, CA 92521, USA
    Eukaryot Cell 6:1200-9. 2007
    Clustered within the genome of the oomycete phytopathogen Phytophthora infestans are four genes encoding spore-specific nuclear LIM interactor-interacting factors (NIF proteins, a type of transcriptional regulator) that are moderately ..
  90. ncbi Role of the cyclic lipopeptide massetolide A in biological control of Phytophthora infestans and in colonization of tomato plants by Pseudomonas fluorescens
    Ha Tran
    Laboratory of Phytopathology, Wageningen University, Wageningen, The Netherlands
    New Phytol 175:731-42. 2007
    Pseudomonas strains have shown promising results in biological control of late blight caused by Phytophthora infestans. However, the mechanism(s) and metabolites involved are in many cases poorly understood...
  91. pmc High-density genetic linkage maps of Phytophthora infestans reveal trisomic progeny and chromosomal rearrangements
    Theo van der Lee
    Laboratory of Phytopathology, Wageningen University, and Graduate School of Experimental Plant Sciences, 6709 PD Wageningen, The Netherlands
    Genetics 167:1643-61. 2004
    Detailed analysis of the inheritance of molecular markers was performed in the oomycete plant pathogen Phytophthora infestans...
  92. ncbi Differential activation of defense-related genes in susceptible and resistant pepper cultivars infected with Phytophthora capsici
    Cristina Silvar
    Departamento de Bioloxia Animal, Bioloxia Vexetal e Ecoloxia, Universidade da Coruna, Campus da Zapateira, Spain
    J Plant Physiol 165:1120-4. 2008
    ..cyclase involved in defense responses in three pepper cultivars with different levels of resistance to Phytophthora capsici...
  93. ncbi Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling
    Pieter van West
    Aberdeen Oomycete Group, College of Life Sciences and Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Microbiology 154:1482-90. 2008
    In the plant pathogen Phytophthora infestans, nuclear integration of inf1 transgenic DNA sequences results in internuclear gene silencing of inf1...
  94. ncbi Internuclear gene silencing in Phytophthora infestans
    P van West
    Laboratory of Phytopathology, Wageningen Agricultural University Graduate School of Experimental Plant Sciences, The Netherlands
    Mol Cell 3:339-48. 1999
    Transformation of the diploid oomycete plant pathogen Phytophthora infestans with antisense, sense, and promoter-less constructs of the coding sequence of the elicitin gene inf1 resulted in transcriptional silencing of both the transgenes ..
  95. ncbi Mapping genes conferring resistance to Phytophthora root rot of soybean, Rps1a and Rps7
    C Weng
    Agriculture and Agri Food Canada, Greenhouse and Processing Crop Research Centre, 2585 Highway 20 E, Harrow, Ontario, N0R 1G0 Canada
    J Hered 92:442-6. 2001
    A linkage map was constructed for two Phytophthora sojae Kauf. +Gerd. root rot resistance genes, Rps1a and Rps7, in soybean (Glycine max (L.) Merr.) using microsatellite or simple sequence repeat (SSR) markers...
  96. ncbi Elevated amino acid biosynthesis in Phytophthora infestans during appressorium formation and potato infection
    Laura J Grenville-Briggs
    Aberdeen Oomycete Group, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Fungal Genet Biol 42:244-56. 2005
    ..is believed to be an important event in establishing a successful interaction between the late blight pathogen, Phytophthora infestans, and its host plants potato and tomato...
  97. ncbi A novel non-protein-coding infection-specific gene family is clustered throughout the genome of Phytophthora infestans
    Anna O Avrova
    Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    Microbiology 153:747-59. 2007
    b>Phytophthora infestans is the cause of late blight, a devastating and re-emerging disease of potato. Significant advances have been made in understanding the biology of P...
  98. ncbi Ancient isolation and independent evolution of the three clonal lineages of the exotic sudden oak death pathogen Phytophthora ramorum
    E M Goss
    USDA ARS, Corvallis, OR 97330, USA
    Mol Ecol 18:1161-74. 2009
    The genus Phytophthora includes some of the most destructive plant pathogens affecting agricultural and native ecosystems and is responsible for a number of recent emerging and re-emerging infectious diseases of plants...
  99. ncbi Phylogenetic analysis of Phytophthora species based on mitochondrial and nuclear DNA sequences
    L P N M Kroon
    Plant Research International, P O Box 16, 6700 AA, Wageningen, The Netherlands
    Fungal Genet Biol 41:766-82. 2004
    A molecular phylogenetic analysis of the genus Phytophthora was performed, 113 isolates from 48 Phytophthora species were included in this analysis...
  100. ncbi Mitochondrial genome sequences and molecular evolution of the Irish potato famine pathogen, Phytophthora infestans
    Cruz Avila-Adame
    Department of Plant Pathology, North Carolina State University, Box 7616, Raleigh, 27695, USA
    Curr Genet 49:39-46. 2006
    The mitochondrial genomes of haplotypes of the Irish potato famine pathogen, Phytophthora infestans, were sequenced...
  101. ncbi Expression of the grapevine stilbene synthase gene VST1 in papaya provides increased resistance against diseases caused by Phytophthora palmivora
    Yun J Zhu
    Hawaii Agriculture Research Center, 99 193 Aiea Heights Drive, Aiea, Hawaii, HI 96701, USA
    Planta 220:241-50. 2004
    ..is susceptible to a variety of fungal diseases, including root, stem, and fruit rot caused by the pathogen Phytophthora palmivora. Since resveratrol at 1.0 mM inhibited mycelium growth of P...

Research Grants6

  1. The Interplay Between the Circadian Clock and Plant Immune Mechanisms
    Xinnian Dong; Fiscal Year: 2013
    ..impact on human health as demonstrated by the infamous Irish potato famine in 1840s, which was caused by Phytophthora infestans, a close relative of Hpa used in this study...
  2. Acylation as an Approach to Enhance the Cancer Preventive Effect of EGCG
    Shengmin Sang; Fiscal Year: 2007
    ..2. To determine the bioavailability and efficacy of acylated EGCG in the prevention of ACF formation in the AOM-treated mouse model. ..
  3. GPCR signaling cascades in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  4. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2009
    ..These studies will enable a genome-wide definition of the gene set contributing to virulence of this common human fungal pathogen. ..
  5. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2010
    ..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores. ..
  6. Role of Calcineurin in Fungal Virulence
    Joseph Heitman; Fiscal Year: 2009
    ..Importantly, this pathway can be targeted for therapeutic intervention using non-immunosuppressive calcineurin inhibitors that retain antifungal activity and synergistic drug combinations that we have discovered. ..