systems analysis

Summary

Summary: The analysis of an activity, procedure, method, technique, or business to determine what must be accomplished and how the necessary operations may best be accomplished.

Top Publications

  1. ncbi Creating a systems approach to patient safety through better teamwork
    Stephen M Powell
    Healthcare Team Training, LLC, USA
    Biomed Instrum Technol 40:205-7. 2006
  2. ncbi The intersection of patient safety and nursing research
    Patricia Hinton Walker
    Graduate School of Nursing, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Annu Rev Nurs Res 24:3-15. 2006
  3. pmc Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa
    Chaoguang Tian
    Department of Plant and Microbial Biology, California Institute for Quantitative Biosciences QB3 Chemistry Mass Spectrometry Facility, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:22157-62. 2009
  4. pmc Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein
    Markus Rehm
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    EMBO J 25:4338-49. 2006
  5. ncbi A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase
    Trevor Hinkley
    ETH Zurich, Institute of Integrative Biology, Zurich, Switzerland
    Nat Genet 43:487-9. 2011
  6. ncbi Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy
    Andreas U Lindner
    Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Cancer Res 73:519-28. 2013
  7. pmc Designing a quality improvement intervention: a systematic approach
    M A van Bokhoven
    Centre for Quality of Care Research Department of General Practice, Maastricht University, The Netherlands
    Qual Saf Health Care 12:215-20. 2003
  8. pmc A dynamical systems analysis of afferent control in a neuromechanical model of locomotion: I. Rhythm generation
    Lucy E Spardy
    Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Neural Eng 8:065003. 2011
  9. ncbi Availability and use of emergency obstetric care services in public hospitals in Laos PDR: a systems analysis
    Xaysomphou Douangphachanh
    Reproductive Health and Research, World Health Organization, Switzerland
    Biosci Trends 4:318-24. 2010
  10. ncbi Bone physiology, disease and treatment: towards disease system analysis in osteoporosis
    Teun M Post
    Pharmacokinetics, Pharmacodynamics, Pharmacometrics P3, Schering Plough, Oss, The Netherlands
    Clin Pharmacokinet 49:89-118. 2010

Detail Information

Publications260 found, 100 shown here

  1. ncbi Creating a systems approach to patient safety through better teamwork
    Stephen M Powell
    Healthcare Team Training, LLC, USA
    Biomed Instrum Technol 40:205-7. 2006
    ....
  2. ncbi The intersection of patient safety and nursing research
    Patricia Hinton Walker
    Graduate School of Nursing, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Annu Rev Nurs Res 24:3-15. 2006
    ....
  3. pmc Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa
    Chaoguang Tian
    Department of Plant and Microbial Biology, California Institute for Quantitative Biosciences QB3 Chemistry Mass Spectrometry Facility, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 106:22157-62. 2009
    ..These results show that the powerful tools available in N. crassa allow for a comprehensive system level understanding of plant cell wall degradation mechanisms used by a ubiquitous filamentous fungus...
  4. pmc Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein
    Markus Rehm
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    EMBO J 25:4338-49. 2006
    ..Our study supports the hypothesis that high levels of XIAP control caspase activation and substrate cleavage, and may promote apoptosis resistance and sublethal caspase activation in vivo...
  5. ncbi A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase
    Trevor Hinkley
    ETH Zurich, Institute of Integrative Biology, Zurich, Switzerland
    Nat Genet 43:487-9. 2011
    ..We find that the fitness landscape of HIV-1 protease and reverse transcriptase is characterized by strong epistasis...
  6. ncbi Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy
    Andreas U Lindner
    Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland
    Cancer Res 73:519-28. 2013
    ..Together, our findings offer a ready clinical tool with the potential to tailor chemotherapy to individual patients...
  7. pmc Designing a quality improvement intervention: a systematic approach
    M A van Bokhoven
    Centre for Quality of Care Research Department of General Practice, Maastricht University, The Netherlands
    Qual Saf Health Care 12:215-20. 2003
    ..Decisions that have to be made during the design process of a quality improvement intervention are visualised, allowing them to serve as a starting point for a systematic evaluation of the intervention...
  8. pmc A dynamical systems analysis of afferent control in a neuromechanical model of locomotion: I. Rhythm generation
    Lucy E Spardy
    Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Neural Eng 8:065003. 2011
    ....
  9. ncbi Availability and use of emergency obstetric care services in public hospitals in Laos PDR: a systems analysis
    Xaysomphou Douangphachanh
    Reproductive Health and Research, World Health Organization, Switzerland
    Biosci Trends 4:318-24. 2010
    ..These data can therefore help government to assign and allocate budgets appropriately, and help policymakers and planners to identify systemic bottlenecks and prioritize solutions and will help in improving maternal health...
  10. ncbi Bone physiology, disease and treatment: towards disease system analysis in osteoporosis
    Teun M Post
    Pharmacokinetics, Pharmacodynamics, Pharmacometrics P3, Schering Plough, Oss, The Netherlands
    Clin Pharmacokinet 49:89-118. 2010
    ....
  11. pmc Persistence of unsafe practice in everyday work: an exploration of organizational and psychological factors constraining safety in the operating room
    S Espin
    Faculty of Community Services, Ryerson University, 350 Victoria Street, Toronto, Canada
    Qual Saf Health Care 15:165-70. 2006
    ....
  12. pmc Communication failures in the operating room: an observational classification of recurrent types and effects
    L Lingard
    University of Toronto, Toronto, Ontario, Canada
    Qual Saf Health Care 13:330-4. 2004
    ..This study was part of a larger project to develop a team checklist to improve communication in the OR...
  13. ncbi Introducing soft systems methodology plus (SSM+): why we need it and what it can contribute
    Jeffrey Braithwaite
    Graduate Management Programs, Faculty of Medicine, University of New South Wales
    Aust Health Rev 25:191-8. 2002
    ....
  14. pmc Glucose sensing in the pancreatic beta cell: a computational systems analysis
    Leonid E Fridlyand
    Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Theor Biol Med Model 7:15. 2010
    ..The goal of this work is to uncover contributions of the cytoplasmic and mitochondrial processes in this secretory coupling mechanism using mathematical modeling in a systems biology approach...
  15. pmc Regulation of release factor expression using a translational negative feedback loop: a systems analysis
    Russell Betney
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    RNA 18:2320-34. 2012
    ..e., control precision) is proportional to eRF1 affinity for the premature stop codon. The validated model represents an important tool to analyze this and other translational negative feedback loops...
  16. pmc Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization
    Jasmin Schmid
    Centre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    J Biol Chem 287:41546-59. 2012
    ....
  17. pmc Systems analysis of MVA-C induced immune response reveals its significance as a vaccine candidate against HIV/AIDS of clade C
    Carmen Elena Gómez
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    PLoS ONE 7:e35485. 2012
    ..Here we describe using systems analysis the biological and immunological characteristics of the attenuated vaccinia virus Ankara strain expressing ..
  18. pmc Systems analysis of quantitative shRNA-library screens identifies regulators of cell adhesion
    Xiaodong Huang
    Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA
    BMC Syst Biol 2:49. 2008
    ....
  19. pmc Linear and nonlinear systems analysis of the visual system: why does it seem so linear? A review dedicated to the memory of Henk Spekreijse
    Robert Shapley
    Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
    Vision Res 49:907-21. 2009
    Linear and nonlinear systems analysis are tools that can be used to study communication systems like the visual system. The first step of systems analysis often is to test whether or not the system is linear...
  20. pmc Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
    Daniel E Zak
    Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 108:11536-41. 2011
    ..Taken together, these results demonstrate that SHARPIN is an essential adaptor downstream of the branch point defined by the panr2 mutation in NEMO...
  21. ncbi Intracranial fluid dynamics in normal and hydrocephalic states: systems analysis with phase-contrast magnetic resonance imaging
    Giovanni De Marco
    Department of Biophysics and Image Processing, Northern Hospital, and University of Picardie Jules Verne, Amiens, France
    J Comput Assist Tomogr 28:247-54. 2004
    ..To present a novel magnetic resonance (MR) method of analysis of cerebrospinal fluid (CSF) flow dynamics...
  22. ncbi Metabolic systems analysis to advance algal biotechnology
    Brian J Schmidt
    Department of Biomedical Engineering, University of Virginia, Health System, Charlottesville, VA 22908, USA
    Biotechnol J 5:660-70. 2010
    ....
  23. ncbi Systems analysis in health care: framework and example
    E Ammenwerth
    Department of Medical Informatics, University Medical Center Heidelberg, Germany
    Methods Inf Med 41:134-40. 2002
    ..Therefore, we aimed to support systematic systems analysis in health care by developing a comprehensive framework that presents and describes potential areas of analysis...
  24. ncbi Measurement of technical efficiency of public hospitals in Kenya: using Data Envelopment Analysis
    Joses M Kirigia
    World Health Organisation, Regional Office for Africa, Medical School, Harare, Zimbabwe
    J Med Syst 26:39-45. 2002
    ..The study singled out the inefficient hospitals and provided the magnitudes of specific input reductions or output increases needed to attain technical efficiency...
  25. ncbi Intracranial pressure waves: characterization of a pulsation absorber with notch filter properties using systems analysis: laboratory investigation
    Rui Zou
    Neurosurgery Department, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Neurosurg Pediatr 2:83-94. 2008
    ..ICP) and arterial blood pressure can be quantitatively characterized using a newly developed technique in systems analysis, the time-varying transfer function...
  26. ncbi Systems analysis of cellular networks under uncertainty
    Hans Michael Kaltenbach
    Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland
    FEBS Lett 583:3923-30. 2009
    ..A deeper understanding, better scaling, and the ability to combine the approaches pose formidable challenges for future theory developments...
  27. pmc Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major
    Arvind K Chavali
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA
    Mol Syst Biol 4:177. 2008
    ..major is the first of its kind for a protozoan. It can serve as a tool for clarifying discrepancies between data sources, generating hypotheses that can be experimentally validated and identifying ideal therapeutic targets...
  28. ncbi Understanding and responding to adverse events
    Charles Vincent
    Department of Surgical Oncology and Technology, Imperial College School of Science, Technology, and Medicine, St Mary s Hospital, London
    N Engl J Med 348:1051-6. 2003
  29. ncbi Biochemical systems analysis of genome-wide expression data
    E O Voit
    Department of Biometry and Epidemiology, 135 Rutledge Avenue, Medical University of South Carolina, Charleston, SC 29425, USA
    Bioinformatics 16:1023-37. 2000
    ..Modern methods of genomics have produced an unprecedented amount of raw data. The interpretation and explanation of these data constitute a major, well-recognized challenge...
  30. pmc Systems analysis unfolds the relationship between the phosphoketolase pathway and growth in Aspergillus nidulans
    Gianni Panagiotou
    Center for Microbial Biotechnology, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark
    PLoS ONE 3:e3847. 2008
    ..niger and A. oryzae. Here we identified the gene coding for a novel metabolic pathway in A. nidulans, namely the phosphoketolase pathway, and investigated the role of an increased phosphoketolase activity...
  31. ncbi An illustration of whole systems thinking
    Kanwal Kalim
    Centre for Health Informatics, City University, London, UK
    Health Serv Manage Res 19:174-85. 2006
    ..Soft systems thinking is the best approach, given the complexity of health care. It is a flexible, cost-effective solution, which should be a prerequisite before any new health policy is launched...
  32. ncbi Computer systems analysis of spaceflight induced changes in left ventricular mass
    Richard L Summers
    Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Comput Biol Med 37:358-63. 2007
    ..This data was further evaluated in a systems analysis approach using a well-established advanced computer model of circulatory functioning...
  33. pmc Systems analysis of small signaling modules relevant to eight human diseases
    Kelly F Benedict
    Department of Biomedical Engineering, University of Virginia Health System, One Boar s Head Pointe, Charlottesville, VA 22908, USA
    Ann Biomed Eng 39:621-35. 2011
    ..addiction, Alzheimer's disease, cancer, diabetes, HIV, heart disease, malaria, and tuberculosis, we show that systems analysis of small (4-25 species), bounded protein signaling modules rapidly generates new quantitative knowledge from ..
  34. pmc Systems analysis of collaboration in 5 national tobacco control networks
    Douglas A Luke
    Center for Tobacco Policy Research, Brown School of Social Work, Washington University in St Louis, St Louis, MO 63112, USA
    Am J Public Health 100:1290-7. 2010
    ....
  35. pmc Large scale physiological readjustment during growth enables rapid, comprehensive and inexpensive systems analysis
    Marc T Facciotti
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
    BMC Syst Biol 4:64. 2010
    ..Therefore, a relatively quick and inexpensive strategy for observing changes in large fractions of the genetic elements is highly desirable...
  36. pmc Optimizing bioconversion pathways through systems analysis and metabolic engineering
    Daniel E Stafford
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:1801-6. 2002
    ..We demonstrate this method in the indene bioconversion network of Rhodococcus modified for the overproduction of 1,2-indandiol, a key precursor for the AIDS drug Crixivan...
  37. ncbi Systems analysis of GLP-1 receptor signaling in pancreatic β-cells
    Yukari Takeda
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Japan
    Am J Physiol Cell Physiol 301:C792-803. 2011
    ..To examine robustness of the signaling system in controlling [cAMP], magnitudes of AC and PDE activities were compared in the presence or absence of GLP-1 and/or the PDE inhibitor IBMX.(1)...
  38. ncbi The critical path method to analyze and modify OR-workflow: integration of an image documentation system
    A Endress
    Department of Obstetrics and Gynecology, University of Tuebingen, Tuebingen, Germany
    Minim Invasive Ther Allied Technol 15:177-86. 2006
    ..It is an appropriate method to transparently show integration possibilities and to define workflow-based requirements for the development process of new systems...
  39. ncbi Complex nursing systems
    Thomas R Clancy
    Professional Services, Mercy Hospital, Iowa City, IA 52245, USA
    J Nurs Manag 13:192-201. 2005
    ..This paper further discusses the merits of computational modelling and simulation which can assist nurse administrators predict the results of their decisions through a virtual complex system environment...
  40. ncbi Integrating patient safety into practice
    Christine Baldrey
    Clinical Nurse Consultant, Continence Service, The Royal Melbourne Hospital, Victoria, Australia
    J Nurs Care Qual 21:14. 2006
  41. ncbi Great Safety Performance: an improvement process using leading indicators
    Dianne Dyck
    Occupational Health and Safety, ENMAX Corporation, Calgary, Alberta
    AAOHN J 52:511-20. 2004
    ..By using the Great Safety Performance model, organizations can design and implement a variety of high leverage improvement initiatives specific to their business situations...
  42. ncbi Clinical risk management and patient safety education for nurses: a critique
    Megan Jane Johnstone
    Division of Nursing and Midwifery, School of Health Sciences, RMIT University, Bundoora, Melbourne, VIC 3083, Australia
    Nurse Educ Today 27:185-91. 2007
    ....
  43. ncbi System weaknesses as contributing causes of accidents in health care
    Sven Ternov
    Ergonomics and Aerosol Technology, Department of Design Sciences, Lund Institute of Technology, Lund, Sweden
    Int J Qual Health Care 17:5-13. 2005
    ..Accidents in health care, resulting in injury or death to the patient, are a matter of considerable concern. The aim of this study is to examine whether system weaknesses can contribute to these accidents, and if so, how...
  44. ncbi Transforming care at the bedside: designing new care systems in an age of complexity
    Mary Viney
    Seton Healthcare Network, and School of Nursing, The University of Texas at Austin, 1700 Red River, Austin, TX 78701, USA
    J Nurs Care Qual 21:143-50. 2006
    ..The article discusses the innovation process and the change cycles, impact of various innovations, and lessons learned...
  45. ncbi Incident reporting in one UK accident and emergency department
    Catherine M Tighe
    Clinical Safety Research Unit, Department of Biosurgery and Surgical Technology, Imperial College, St Mary s Campus, Praed Street, London W2 1NY, United Kingdom
    Accid Emerg Nurs 14:27-37. 2006
    ..This research may have implications for the incident reporting process in other specialities as well as in other hospitals...
  46. ncbi Safety in the academic medical center: transforming challenges into ingredients for improvement
    David Blumenthal
    Institute for Health Policy, Massachusetts General Hospital and Partners Health System, 55 Fruit Street, Boston, MA 02114, USA
    Acad Med 81:817-22. 2006
    ....
  47. pmc FMEA and RCA: the mantras of modern risk management
    J W Senders
    Toronto, Ontario M6R 2X5, Canada
    Qual Saf Health Care 13:249-50. 2004
  48. pmc Analysis of clinical incidents: a window on the system not a search for root causes
    C A Vincent
    Qual Saf Health Care 13:242-3. 2004
    ..3 New risk management and patient safety programmes-whether local or national-rely on incident reporting to provide data on the nature of safety problems and to provide indications of the causes of those problems and the likely solutions...
  49. pmc Quality and safety by design
    J B Battles
    Agency for Healthcare Research and Quality AHRQ, Center for Quality Improvement and Patient Safety, 540 Gather Road, Rockville, MD 20850, USA
    Qual Saf Health Care 15:i1-3. 2006
    ..In order to bring about major improvements in quality and safety, these design methods can and should be used to redesign healthcare delivery systems...
  50. ncbi Interview with Frances A. Griffin, Institute for Healthcare Improvement. Interview by Diane E. Featherston
    Frances A Griffin
    J Nurs Care Qual 20:369-72. 2005
  51. pmc A human factors engineering paradigm for patient safety: designing to support the performance of the healthcare professional
    B T Karsh
    Industrial and Systems Engineering, University of Wisconsin Madison, Madison, WI, USA
    Qual Saf Health Care 15:i59-65. 2006
    ..The concepts of human performance and hazard reduction are explained...
  52. ncbi Industrial strength. Patient safety means leading pre-industrial health care into a post-industrial world
    Chuck Appleby
    Trustee 55:10-4, 19, 2. 2002
    ..Innovative methods of improving patient safety--including one pioneered by Toyota--highlight the need for hospitals and their staff to adopt a post-industrial mindset...
  53. ncbi Expertise isn't the only answer to leadership in safety
    Karlene Kerfoot
    Nursing and Patient Care Services, Clarian Health, Indianapolis, IN, USA
    Nurs Econ 23:100-2. 2005
    ..In the words of Collins (2001), "Good is the enemy of Great" (p. 1). With new eyes that represent diverse cognitive skills, we will overcome our blindness to defects and move from good to great...
  54. ncbi Patient safety: planting the seed
    Stephanie S Poe
    Johns Hopkins Hospital, The Johns Hopkins University School of Nursing, Baltimore, MD 21287, USA
    J Nurs Care Qual 20:198-202. 2005
  55. ncbi Error recovery in a hospital pharmacy
    L Kanse
    University of Queensland, Brisbane, Australia
    Ergonomics 49:503-16. 2006
    ..Guidance is given on how performance in recovery could be measured. A case is made for supporting recovery as an addition to prevention-based safety methods...
  56. ncbi How can we improve the nursing work environment?
    Julie Holden
    Maternal Newborn Services, Melrose Wakefield Hospital, Melrose, MA, USA
    MCN Am J Matern Child Nurs 31:34-8. 2006
    ..This transformation could mean that the terms "Nursing Organizations" and "Learning Organizations" would not have to be oxymorons...
  57. ncbi Narrativizing errors of care: critical incident reporting in clinical practice
    Rick Iedema
    Centre for Clinical Governance Research, School of Public Health and Community Medicine, The University of New South Wales, Sydney 2052 NSW, Australia
    Soc Sci Med 62:134-44. 2006
    ....
  58. pmc "Going solid": a model of system dynamics and consequences for patient safety
    R Cook
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, IL 60615, USA
    Qual Saf Health Care 14:130-4. 2005
    ..Because the model addresses the dynamic aspects of safety, it is particularly suited to understanding current conditions in modern healthcare delivery and the way these conditions may lead to accidents...
  59. pmc Will the future continue to repeat the past?
    S J Woodward
    Qual Saf Health Care 14:74. 2005
  60. ncbi Case management and patient safety: opportunities for process and performance improvement
    Sherrie Dulworth
    Milliman Care Guidelines, Seattle, Wash, USA
    Case Manager 16:69-72; quiz 73. 2005
    ..Some case managers voice doubts about the ability to affect safety because they typically are not direct caregivers. Is it realistic to expect case managers and their organizations to influence and improve patient safety?..
  61. ncbi [List of complications--reduction of errors and complications by elimination of unsafe actions and conditions]
    M Staubli
    Medizinische Abteilung, Spital Zollikerberg, Zollikerberg
    Ther Umsch 62:199-204. 2005
    ..The principle for the reduction of such events is the elimination of unsafe actions and conditions and apparently harmless errors in daily diagnostic and therapeutic interventions in order to avoid the potentially serious consequences...
  62. ncbi Patient safety and the art and science of medicine
    William F Minogue
    Maryland Patient Safety Center, USA
    Md Med 6:13-5. 2005
  63. ncbi [Failure prevention in clinical practice through identification of failure examples]
    M L Hansis
    RHON KLINIKUM AG, Bad Neustadt
    Ther Umsch 62:179-83. 2005
    ..Recognizing patterns of underlying causes for errors is the key to effective error prevention. In many cases the true cause might be predominantly organizational...
  64. ncbi [Preliminary results of an anonymous internet-based reporting system for critical incidents in ambulatory primary care]
    A Brun
    Facharzt FMH fürAllgemeinmedizin, Hauptstrasse 14, CH 3512, Walkringen
    Ther Umsch 62:175-8. 2005
    ..As incentives for more intensive participation there are the hope for comments on reported cases by other participants and the expectation that reported errors will be avoided by the readers...
  65. ncbi [Critical incidents]
    D Scheidegger
    Departement Anästhesie, Universitäitsspital Basel
    Ther Umsch 62:169-74. 2005
    ....
  66. ncbi [Experiences with "incident reporting" at the East Switzerland Childrens Hospital]
    B Kehrer
    Facharztfür Kinderchirurgie, Tutilostrasse 5, CH 9011 St Gallen
    Ther Umsch 62:161-7. 2005
    ..In Switzerland a National Foundation for Patient Safety has been created for supporting all the acting professionals in the healthcare system in their challenging task...
  67. ncbi Implementation of patient centeredness to enhance patient safety
    Karin Janine Berntsen
    Jamul, CA 91935, USA
    J Nurs Care Qual 21:15-9. 2006
  68. ncbi Creating an organizational culture for medication safety
    Robin Donohoe Dennison
    University of Kentucky College of Nursing, Lexington, KY, USA
    Nurs Clin North Am 40:1-23. 2005
    ..collaboration; Staffing: adequate number and staffing mix; Administration support for the clinical goal of patient safety; Failure mode and effects analysis with team member involvement; Environment and equipment to support patient safety..
  69. pmc Violations and migrations in health care: a framework for understanding and management
    R Amalberti
    IMASSA, Cognitive Science Department, Bretigny sur Orge, France
    Qual Saf Health Care 15:i66-71. 2006
    ..Violations cannot be eliminated but they can be managed. Solutions are specific to each step of the model, with a mix of relaxing constraints, increasing peer control (staff), and constraining dangerous individuals...
  70. pmc Accidents waiting to happen: the contribution of latent conditions to patient safety
    C M Lowe
    NHS National Patient Safety Agency, 4 8 Maple Street, London W1T 5HD, UK
    Qual Saf Health Care 15:i72-5. 2006
    ..A better understanding of these elements and specific healthcare design challenges will result in improved patient safety...
  71. ncbi First do no harm: integrating patient safety and quality improvement
    Zubina Mawji
    Lehigh Valley Hospital and Health Network, 1210 S Cedar Crest Blvd, Suite 3600, Allentown, PA 18103, USA
    Jt Comm J Qual Improv 28:373-86. 2002
    ..The projects stress delivery of cost-effective medical care while reducing preventable adverse events through improved communication, process redesign, and evidence-based protocol use...
  72. ncbi Breaking the error chain
    David Crouch
    Nurs Times 99:22-5. 2003
  73. ncbi St. John Health System and patient safety
    Francis Wilson
    Medical Services, St John Health System, Warren, Michigan, USA
    Qual Manag Health Care 12:46-52. 2003
    ..John Health System developed a comprehensive approach to improving patient safety and how that was implemented in our 8 hospital system with independent medical staffs...
  74. ncbi Nursing is essential to improving patient safety
    Pamela Mitchell
    J Adv Nurs 38:109-10. 2002
  75. ncbi Human factors and systems engineering approach to patient safety for radiotherapy
    A Joy Rivera
    Industrial and Systems Engineering, University of Wisconsin Madison, Madison, WI 53706, USA
    Int J Radiat Oncol Biol Phys 71:S174-7. 2008
    ..However, an understanding of the human factors and systems engineering is lacking, and confusion remains about what it means to apply their principles. This paper provides a primer on them and their applications to patient safety...
  76. ncbi Patient Safety Leadership WalkRounds
    Allan Frankel
    Partners HealthCare System, Boston, USA
    Jt Comm J Qual Saf 29:16-26. 2003
    ..Executives are surveyed quarterly about actions they have taken as a direct result of WalkRounds and are asked what they have learned from the rounds...
  77. ncbi John M. Eisenberg Patient Safety Awards. System innovation: Veterans Health Administration National Center for Patient Safety
    Jeffrey R Heget
    Veterans Affairs VA National Center for Patient Safety, 24 Frank Lloyd Wright Drive, Lobby M, P O Box 486, Ann Arbor, MI 48106 0486, USA
    Jt Comm J Qual Improv 28:660-5. 2002
    ..NCPS's aim is to foster a culture of safety in the Department of Veterans Affairs (VA) by developing and providing patient safety programs and delivering standardized tools, methods, and initiatives to the 163 VA facilities...
  78. pmc Educating physicians prepared to improve care and safety is no accident: it requires a systematic approach
    D C Aron
    Education Office 14 W, Louis Stokes Cleveland DVA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Qual Saf Health Care 11:168-73. 2002
    ..We apply a systems analysis from the field of human error to identify ways in which medical school education can increase the number of ..
  79. ncbi The Veterans Affairs root cause analysis system in action
    James P Bagian
    VA National Center for Patient Safety, 2215 Fuller Drive, Ann Arbor, MI 48105, USA
    Jt Comm J Qual Improv 28:531-45. 2002
    ..The cases illustrate that broadly applicable, high-impact actions can result from a thorough RCA process...
  80. ncbi From blaming to proactively changing the future: the leader's safety challenge
    Karlene M Kerfoot
    Aurora Health System, Milwaukee, WI, USA
    Nurs Econ 26:280-1. 2008
    ..Many nurses have left their positions because they have chosen not to work in a culture of blame. Eliminating all forms of blame is essential for excellence in patient care outcomes and loyalty of staff...
  81. ncbi Root cause analysis in perinatal care: health care professionals creating safer health care systems
    M M Boyer
    The Women's Center at University Community Hospital, Tampa, Florida, USA
    J Perinat Neonatal Nurs 15:40-54. 2001
    ..Risk reduction strategies are presented to make this process meaningful and efficient while promoting the ultimate goal of safer health care systems...
  82. ncbi The safety checklist program: creating a culture of safety in intensive care units
    Marcia M Piotrowski
    VA Ann Arbor Healthcare System VAAAHS, Ann Arbor, Michigan, USA
    Jt Comm J Qual Improv 28:306-15. 2002
    ....
  83. ncbi Using health care Failure Mode and Effect Analysis: the VA National Center for Patient Safety's prospective risk analysis system
    Joseph DeRosier
    Department of Veterans Affairs, VA National Center for Patient Safety 10X, 24 Frank Lloyd Wright Drive, Lobby M, PO Box 486, Ann Arbor, MI 48106 0486, USA
    Jt Comm J Qual Improv 28:248-67, 209. 2002
    ..The authors describe HFMEA, a five-step process used to proactively evaluate a health care process, and provide examples of a team's forms and actions regarding prostate-specific antigen testing...
  84. ncbi A user's manual for the IOM's 'Quality Chasm' report
    Donald M Berwick
    Institute for Healthcare Improvement, Boston, USA
    Health Aff (Millwood) 21:80-90. 2002
    ....
  85. ncbi Improving medication safety and patient care in the emergency department
    Christopher E Schmidt
    Nurse Corps, United States Navy, and Emergency Department, Naval Hospital Jacksonville, Jacksonville, Fla, USA
    J Emerg Nurs 29:12-6. 2003
    ..Through participation in a nationwide institute for healthcare improvement initiative, our emergency department performance improvement group focused on human and system factors that contributed to potential medication errors...
  86. ncbi National Patient Safety Agency: improving patient safety across all critical care areas
    Simon Keady
    Women and Children s Services, University College London Hospitals NHS Foundation Trust, UK
    Intensive Crit Care Nurs 24:137-40. 2008
    ..This article gives an insight into the rationale and steps currently being undertaken to respond to these recommendations...
  87. ncbi How to make the most of failure mode and effect analysis
    Erik Stalhandske
    Department of Veterans Affairs National Center for Patient Safety, 24 Frank Lloyd Wright Drive, Lobby M, PO Box 486, Ann Arbor, MI 48106, USA
    Biomed Instrum Technol 37:96-102. 2003
    ..For additional information on HFMEA, visit the VA website at www.patientsafety.gov/HFMEA.html...
  88. ncbi Pursuing safe medication use and the promise of technology
    Zane Robinson Wolf
    La Salle University, School of Nursing and Health Sciences, Philadelphia, PA, USA
    Medsurg Nurs 16:92-100. 2007
    ..They use technologic innovations aimed at error prevention, yet medication errors persist. The importance of improved decision making through computerized systems in the prevention of medication errors is emphasized...
  89. ncbi Incident reports--correcting processes and reducing errors
    Debra Dunn
    St Joseph s Wayne Hospital, NJ, USA
    AORN J 78:212, 214-6, 219-20, passim; quiz 235-8. 2003
    ..The steps that guide managers in adapting an incident reporting system that incorporates continuous quality improvement are identified...
  90. pmc Stopping the error cascade: a report on ameliorators from the ASIPS collaborative
    Bennett Parnes
    Department of Family Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045 0508, USA
    Qual Saf Health Care 16:12-6. 2007
    ..To present a novel examination of how error cascades are stopped (ameliorated) before they affect patients...
  91. ncbi Cutting healthcare costs without preventable clinical incidents--together we can improve
    W Nicklin
    Ottawa Hospital and School of Nursing, Queen's University, Ottawa
    Healthc Pap 2:66-70, discussion 86-9. 2001
    ..Finally, the litigious sensitivity of the public and healthcare systems overall intensifies the "error" element. This element is counter-productive to the openness required for the systems approach...
  92. ncbi Making patients safer! Reducing error in Canadian healthcare
    G R Baker
    Department of Health Administration, University of Toronto
    Healthc Pap 2:10-31. 2001
    ..These are not easy tasks and will require investments in new equipment and new skills. These steps are essential if we are to maintain public confidence in healthcare...
  93. ncbi Malpractice prevention, patient safety, and quality of care: a critical linkage
    L Gregory Pawlson
    National Committee for Quality Assurance, 2000 I Street, NW, Suite 500, Washington, DC 20036, USA
    Am J Manag Care 10:281-4. 2004
    ....
  94. ncbi Creating a culture of safety
    Shelia Allen
    International Federation of Perioperative Nurses
    J Perioper Pract 17:244-6. 2007
  95. ncbi Safeguarding patients: complexity science, high reliability organizations, and implications for team training in healthcare
    Leslie M McKeon
    College of Nursing, Univeristy of Tennessee Health Science Center, Memphis, TN 38163, USA
    Clin Nurse Spec 20:298-304; quiz 305-6. 2006
    ..Cultural and system barriers to achieving high reliability performance within healthcare and implications for team training are discussed...
  96. ncbi Transforming care at the bedside: implementation and spread model for single-hospital and multihospital systems
    Susan Christie Martin
    Center for Quality Improvement and Innovation, University of Pittsburgh Medical Center, 4601 Baum Boulevard, Pittsburgh, PA 15213, USA
    J Nurs Adm 37:444-51. 2007
    ..The authors describe Transforming Care at the Bedside as implemented by one of Institute for Healthcare Improvement/Robert Wood Johnson's initial pilot hospitals, including promising outcomes and a model for spreading the initiative...
  97. ncbi Challenges in delivering safe patient care: a commentary on a quality improvement initiative
    Lynne Currie
    Quality Improvement Programme, RCN Institute, Radcliffe Infirmary, Oxford, UK
    J Nurs Manag 15:162-8. 2007
    ..In conclusion, the paper describes the implications arising from the quality improvement initiative and the need for further research exploring the nature of safety culture in health-care organizations...
  98. ncbi Replacements of single basic amino acids in the pleckstrin homology domain of phospholipase C-delta1 alter the ligand binding, phospholipase activity, and interaction with the plasma membrane
    H Yagisawa
    Department of Life Science, Faculty of Science, Himeji Institute of Technology, Harima Science Garden City, Hyogo 678 12, Japan
    J Biol Chem 273:417-24. 1998
    ..All residues (with the exception of the K43E substitution) found to be critical for the analyzed PLC-delta1 functions are present at the surface of the PH domain shown to contain the Ins(1,4,5)P3 binding pocket...
  99. ncbi The future of human spaceflight
    M Reichert
    German Aerospace Center DLR, 53183 Bonn, Germany
    Acta Astronaut 49:495-522. 2001
    ..roadmaps are investigated for space tourism and human missions to the Moon and Mars, based on a comprehensive systems analysis approach...
  100. ncbi Metabolite stress and tolerance in the production of biofuels and chemicals: gene-expression-based systems analysis of butanol, butyrate, and acetate stresses in the anaerobe Clostridium acetobutylicum
    Keith V Alsaker
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA
    Biotechnol Bioeng 105:1131-47. 2010
    ....
  101. ncbi Access to community pharmacies by the elderly in Illinois: a geographic information systems analysis
    Swu Jane Lin
    Department of Pharmacy Administration, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
    J Med Syst 28:301-9. 2004
    ..The geographic access to community pharmacies appears to be appropriate in Illinois. However, a small portion of rural elderly who do not have a pharmacy in their nearby areas may warrant special attention...

Research Grants73

  1. CSHL 2010 Conference on Molecular Genetics and Bacteria & Phages
    David J Stewart; Fiscal Year: 2010
    ..areas such as genomics and metagenomics, sociomicrobiology, molecular ecology, structural biology and systems analysis. For many graduate students and postdoctoral fellows, this is the first large meeting at which they have an ..
  2. 2012 CSHL Bacteria &Phages Conference
    David J Stewart; Fiscal Year: 2012
    ..areas such as genomics and metagenomics, sociomicrobiology, molecular ecology, structural biology and systems analysis. For many graduate students and postdoctoral fellows, this is the first large, international meeting at which ..
  3. Systems Analysis of Cardiac Chromatin Structure
    Thomas M Vondriska; Fiscal Year: 2013
    ..The significance to the clinical realm is to provide a mechanistic basis for how the genome is reprogrammed with disease, such that future therapies can target specific chromatin remodeling events. ..
  4. Biomedical Computing Support of Cancer Control and Surveillance
    DAVID RONEY; Fiscal Year: 2009
    ..This Contract provides computer systems analysis, programming, data management, data analysis, statistical reporting, and documentation services for research ..
  5. Systems analysis of TGFbeta signaling and SnoN function in liver
    Kunxin Luo; Fiscal Year: 2013
    ..The long-term goal of this project is to understand how proper levels of TGF2 signaling activity are maintained and regulated in normal tissues and primary cells using a system biology approach. ..
  6. Physical and Functional Systems Analysis of Mammalian Mitochondria
    JODI M NUNNARI; Fiscal Year: 2013
    ..Collectively, these objectives are designed to provide new insights into the complex etiologies of diseases and have the potential to identify novel therapeutic avenues. ..
  7. Prognostic &Therapeutic Implications of Breathing Patterns in Acute Lung Injury
    FRANK JOSEPH JACONO; Fiscal Year: 2013
    ..as changes in variability of respiratory patterns with ALI and VALI are not appreciated, and a complex systems analysis approach has not previously been applied to these important clinical conditions...
  8. Impact of Presenilin 2 Mutation and Deficiency on Microglial Function
    Suman Jayadev; Fiscal Year: 2010
    ..b>Systems analysis of multiple genomic datasets reveals PS2 is overrepresented in immune pathways and is co-regulated with ..
  9. Application of Omics in Lung Disease
    Claire M Doerschuk; Fiscal Year: 2013
    ..Our Program consists of four omics, leading expertise in bioinformatics, integrative systems analysis of complex biological systems, and clinical research, as well as opportunities to use cohorts in large ..
  10. RECEPTOR INTERACTION WITH GTP-REGULATORY PROTEINS
    Gary L Johnson; Fiscal Year: 2012
    ..Cumulatively, this work represents a mechanistic systems analysis of the function and regulation of an important MAP3K, MEKK1, which is critical in the control of homeostasis...
  11. Environment Change and Diarrheal Disease: A Natural Experiment
    Joseph N S Eisenberg; Fiscal Year: 2012
    ..coli strains over time and across our study region (Specific Aim 2);and 3) Systems analysis to model the role that social capital and migration play in the transmission of enteric pathogens, and to ..
  12. Receptor Tyrosine Kinase Signaling Networks
    Joannes B Hoek; Fiscal Year: 2010
    ..considerable potential of a novel cross-disciplinary approach that combines experimental studies, nonlinear systems analysis and interactive computational models to achieve a quantitative understanding of RTK signaling networks...
  13. AUDITORY MEMORIES AND VOCAL LEARNING
    Frederic E Theunissen; Fiscal Year: 2013
    ..experiments, we will analyze the neurons'tuning and selectivity using state-of-the-art techniques from systems analysis and information theory...
  14. Forebrain circuits and control of feeding behavior by learned cues
    Gorica D Petrovich; Fiscal Year: 2013
    ..The proposed goals will be accomplished with a combination of behavioral and neural systems analysis that include selective neurotoxic lesions, anatomical pathway tracing, and imaging with immediate early genes ..
  15. Proteomic analysis of eukaryotic protein synthesis
    Andrew J Link; Fiscal Year: 2010
    ..Hence a comprehensive understanding of protein synthesis is needed for systems analysis of both the normal and disease-altered translation process...
  16. Systems Analysis Vaccine Responses in Healthy and Hyporesponsive Humans
    Anna Karolina Palucka; Fiscal Year: 2013
    ..abstract_text> ..
  17. DEVELOPMENT OF A PRIMATE GENOMIC RESOURCE
    Michael G Katze; Fiscal Year: 2012
    ..To build these resources, we have teamed with the Biological Systems Analysis and Mass Spectrometry group headed by Dr. Richard D. Smith at Pacific Northwest National Laboratory...
  18. Hsp90 Dependent Rab Tethering
    WILLIAM EDWARD BALCH; Fiscal Year: 2012
    ..vesicular traffic in the exocytic and endocytic pathways, a result now strongly supported by a comprehensive systems analysis of Hsp90 function in yeast...
  19. microRNAs and integrative control of cardiopoiesis
    Mark Mercola; Fiscal Year: 2013
    ..is innovative in that it merges state of the art functional screening of miRs with miR target identification and systems analysis in order to expose the logic underying the emergence of distinct cell types in the heart from stem cells.
  20. Systems analysis of transcriptional interactions underlying foam cell formation
    Stephen A Ramsey; Fiscal Year: 2013
    ..Ramsey to achieve his career goal of becoming an independent investigator in cardiovascular disease-related research, equipped to use experimental and quantitative methods in a synergistic manner. ..
  21. Dissecting the neural control of social attachment
    NIRAO MAHESH SHAH; Fiscal Year: 2011
    ..genetic tools with behavioral analysis, high resolution anatomic and functional neural circuit mapping, and systems analysis of signaling to understand how the brain normally generates social attachments...
  22. Dissecting the neural control of social attachment
    NIRAO MAHESH SHAH; Fiscal Year: 2013
    ..genetic tools with behavioral analysis, high resolution anatomic and functional neural circuit mapping, and systems analysis of signaling to understand how the brain normally generates social attachments...
  23. An in vitro-in vivo correlation model to predict serum non-transferrin bound iron
    Amy Barton Pai; Fiscal Year: 2013
    ..Specific Aim 4. Establish the relationship between in vitro labile iron data and in vivo NTBI data - A systems analysis approach will be utilized to establish an IVIVC for each IV iron complex formulation.
  24. Gene Function and Pathway Analysis Using Systems Level Approaches in Prokaryotes
    CAROL ANNE GROSS; Fiscal Year: 2013
    ..Thus, we function at the interface between systems analysis and mechanistic biology...
  25. Systems Approach to Immunity and Inflammation
    Richard J Ulevitch; Fiscal Year: 2013
    ..group will focus on mice identified by exome sequencing to have ENU induced mutations in genes predicted by systems analysis to be critical regulators of immune ceil networks and will establish the role of these genes in the immune ..
  26. Understanding Disparities in Obesity and its Comorbidities in the US
    Youfa Wang; Fiscal Year: 2010
    ..Aim 3: To conduct simulation analyses using systems analysis approaches to examine the effects of potential interventions and scenarios for helping eliminate the ..
  27. Heart Failure Readmissions in Older Adults: A systems Perspective
    LEORA HORWITZ; Fiscal Year: 2013
    ..group of large datasets;and (4) to develop advanced expertise in organizational behavior, human ergonomics, systems analysis and other techniques necessary for building safe and patient-centered healthcare systems...
  28. An Advanced Technology Flat-Panel Imager for Fluoroscopy
    Larry E Antonuk; Fiscal Year: 2012
    ..2) Quantitative modeling (involving cascaded systems analysis and detailed circuit simulations) to provide guidance in array design and assist in prototype evaluation...
  29. A systems approach to metabolic dysregulation in the heart
    Mohit Jain; Fiscal Year: 2013
    ..aims to leverage his prior training in cardiovascular physiology and disease with newly acquired skills in systems analysis, genomics, metabolomics and macro-molecule mass spectrometry within a structured and mentored scientific ..
  30. Cadiorenal and Metabolic Diseases Research Center
    John E Hall; Fiscal Year: 2013
    ..disease research at UMMC by recruiting new faculty with expertise in clinical and translational research and in emerging technologies, such as in vivo imaging, molecular genetics, bioinformatics, and systems analysis.
  31. Physiological Genomics of Critical Illness and Injury
    J Perren Cobb; Fiscal Year: 2009
    ..the goal of which is to bring together those with the diverse skills sets necessary to apply genomics and systems analysis to the study of critical illness and injury...
  32. Complex Systems & Control of MMR-Deficient Cells
    Kenneth Loparo; Fiscal Year: 2009
    ..Through an iterative process that involves model development and systems analysis, experimentation and data collection, model testing and validation, and a detailed study of coordination and ..
  33. 2010 Neurobiology of Cognition Gordon Research Conference
    Xiao Jing Wang; Fiscal Year: 2010
    ..Neuroscience that have begun to uncover the brain circuit basis of higher cognitive functions at the level of systems analysis, computational principles, and neurophysiological mechanisms...
  34. Quantitative tools for investigating sensory systems
    Frederic E Theunissen; Fiscal Year: 2010
    ..The algorithms represent modern improvements to the classical engineering systems analysis approach that could only be applied to the most peripheral stages of sensory processing...
  35. Towards Effective and Efficient Adoption of Health IT in Home Health Care
    Günes Koru; Fiscal Year: 2013
    ..far, the pressing challenges and opportunities of HHAs have not been sufficiently studied from an information systems analysis perspective...
  36. Systems analysis of cell type differentiation in xenopus development
    MARC WALLACE KIRSCHNER; Fiscal Year: 2013
    ..Such studies could facilitate the development of procedures to direct cell differentiation in ways that would ultimately contribute to regenerative medicine in the treatment of important human diseases. ..
  37. TRAINING IN THE NEUROPLASTICITY OF AGING
    Edward H Koo; Fiscal Year: 2013
    ..technical expertise in the fields of Molecular Genetics, Protein Chemistry, Cell Biology, Neurophysiology, Systems Analysis, Pharmacology, Cognitive Neuroscience, Computational Neuroscience, and Clinical Neurology...
  38. Systems Analysis of BMP Regulation in Developing Zebrafish Embryos
    DAVID MICHAEL UMULIS; Fiscal Year: 2013
    ..Understanding the mechanism of BMP-mediated patterning in vertebrates will provide the basis for tightly controlling BMP signaling in tissue regeneration and other prospective treatments of human disease. ..
  39. Imaging in 2020-VIII: Integrating Molecular Imaging and Complex Biology
    Thomas J Meade; Fiscal Year: 2012
    ..systems, animal and theoretical models to assess biological systems and the use of imaging in computational systems analysis. This year will expand the diversity of the scientists that gather in Jackson Hole to include systems ..
  40. HIPPOCAMPAL AND CORTICAL CODING IN MEMORY
    Howard B Eichenbaum; Fiscal Year: 2013
    ..To understand the information processing mechanisms that underlie episodic memory, we propose a systems analysis that will compare the nature of information processing and identify functional interactions between cortical ..
  41. Development of Bimanual Coordination of Early Childhood
    KAREN E BRAKKE; Fiscal Year: 2010
    ..Individual developmental trajectories will be mapped according to the principles and methods of developmental systems analysis. Additionally, introduction of auditory or human models will allow the investigator to determine whether ..
  42. Identifying network pertubation using secreted protein profiles in glioblastoma
    Nathan D Price; Fiscal Year: 2011
    ..but chose to defer this position for 2-3 years for the express purpose of transitioning his career focus onto systems analysis of cancer. The mentored phase of this award will provide Dr...
  43. Causes and Interventions for Childhood Obesity:Innovative Systems Analysis
    Youfa Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Causes and Interventions for Childhood Obesity: Innovative Systems Analysis Obesity has become a public health crisis in the United States...
  44. Johns Hopkins Pediatric Obesity Research and Training Center
    Youfa Wang; Fiscal Year: 2012
    ..The Center will build upon a solid research and training base with ongoing NIH funded projects directly related to childhood obesity and systems analysis.
  45. Mouse Genetic Resources for Multigeneic Disease Analysis
    Nathan A Berger; Fiscal Year: 2012
    ..CSSs are a statistically powerful way to dissect the genetic control of these traits, simultaneously enabling gene discovery, functional studies, and systems analysis.
  46. Mouse Genetic Resources for Multigeneic Disease Analysis
    Nathan A Berger; Fiscal Year: 2011
    ..CSSs are a statistically powerful way to dissect the genetic control of these traits, simultaneously enabling gene discovery, functional studies, and systems analysis.
  47. Computational investigation of neuropathic changes in primary afferent excitabili
    Steven A Prescott; Fiscal Year: 2012
    ..modeling will be used to replicate cellular excitability changes in minimal computer models so that dynamical systems analysis can be used to explain excitability changes on the basis of altered nonlinear interactions...
  48. Systems Analysis of Inflammatory Pathways in HIV Infection
    DANA H GABUZDA; Fiscal Year: 2013
    ..abstract_text> ..
  49. Systems Analysis and Improvement to Optimize pMTCT: A Cluster Randomized Trial
    Kenneth Sherr; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Systems Analysis and Improvement to Optimize pMTCT: A Cluster Randomized Trial...
  50. Chemistry and Mechanisms for Environmental Stress
    Daniel C Liebler; Fiscal Year: 2013
    ..Toxicology" and highlights the implementation of global profiling technologies and data integration tools for systems analysis. The second is entitled "Chemistry and Biology of Metal Toxicity" and focuses on new mechanistic studies of ..
  51. Infrared microscopy for a systems approach to prostate pathology
    Rohit Bhargava; Fiscal Year: 2013
    ..Predictions will be compared to the clinical standard today (Kattan nomogram). A systems analysis approach is proposed to examine important histologic and chemical transformations that characterize ..
  52. Modeling the Role of Differentiation in Cancer Progression
    SYLVIA KATINA PLEVRITIS; Fiscal Year: 2013
    ..The Stanford CCSB will develop three essential and interlocking methods for a comprehensive systems analysis of cancer...
  53. NRSA Training Grant in Quantitative Neuroscience
    Kenneth A Norman; Fiscal Year: 2013
    ..neuroscience, ranging from information-theoretic analyses of neuronal spiking and nonlinear dynamical systems analysis of decision- making to multivariate decoding of human neuroimaging data...
  54. A Systems Approach for Community-Linked Health Research Across the "Plaza"
    MAGDA G PECK; Fiscal Year: 2010
    ..and reach greater shared understanding of community health issues amenable to collaborative research;data systems analysis, inventory, assessment and redesign to inform research priorities and support future research;development and ..
  55. SYSTEMS ANALYSIS OF HEAD STABILIZATION
    Barry Peterson; Fiscal Year: 1999
    ....
  56. IN VIVO DETECTION OF FREE RADICALS USING NMR
    Thomas Clanton; Fiscal Year: 2000
    ..abstract_text> ..
  57. PERCEPTUAL ORGANIZATION OF TWO DIMENSIONAL PATTERNS
    Wilson S Geisler; Fiscal Year: 2013
    ..In our lab we call this "natural systems analysis." This novel approach to vision science is composed of several steps: (1) identify natural tasks, (2) measure ..
  58. Neuromarkers of Social Coordination: A Dynamical Approach
    J A Scott Kelso; Fiscal Year: 2012
    ..The research represents a first attempt to incorporate dynamical systems analysis into the study of socially-mediated neurophysiological activity in conscious, interacting humans...
  59. BIOMEDICAL COMPUTING SUPPORT FOR THE DIVISION OF CANCER CONTROL AND POPULATION S
    DAVID RONEY; Fiscal Year: 2013
    ..The support provided are in the areas of (1) computer systems analysis, (2) programming, (3) data management, (4) data analysis, (5) statistical reporting, (6) WWW development and (..
  60. BIOMEDICAL COMPUTING SUPPORT FOR THE DIVISION OF CANCER CONTROL AND POPULATION S
    DAVID RONEY; Fiscal Year: 2012
    ..The support provided are in the areas of (1) computer systems analysis, (2) programming, (3) data management, (4) data analysis, (5) statistical reporting, (6) WWW development and (..
  61. BIOMEDICAL COMPUTING SUPPORT FOR THE DIVISION OF CANCER CONTROL AND POPULATION S
    DAVID RONEY; Fiscal Year: 2010
    ..The support provided are in the areas of (1) computer systems analysis, (2) programming, (3) data management, (4) data analysis, (5) statistical reporting, (6) WWW development and (..
  62. BIOMEDICAL COMPUTING SUPPORT FOR THE DIVISION OF CANCER CONTROL AND POPULATION S
    DAVID RONEY; Fiscal Year: 2011
    ..The support provided are in the areas of (1) computer systems analysis, (2) programming, (3) data management, (4) data analysis, (5) statistical reporting, (6) WWW development and (..
  63. PROCESSES OF VISUAL TRACKING
    Martin Gizzi; Fiscal Year: 1993
    ..Phase I training includes instruction in neuro-ophthalmology, control systems analysis, electro-oculography and infrared oculography in humans, the use of magnetic search coils an physiological ..
  64. BLOOD PRESSURE & RENAL FUNCTION IN HYPERINSULINEMIA
    John Hall; Fiscal Year: 1991
    ..A systems analysis of the interrelationships between insulin, body fluid homeostasis, and arterial pressure regulation will be ..
  65. Interrogation of systems level mechanisms controlling DNA repair processes
    Nitin S Baliga; Fiscal Year: 2010
    ..This hypothesis is motivated by two main observations: a. in systems analysis of UV response, although extraordinarily resistant, not all expected repair genes in this microbe responded ..
  66. IMPACT OF CAPITATION ON MH SERVICES TO THE CMI
    ARIE SCHINNAR; Fiscal Year: 1992
    ..Although the study is structured in a quasi-experimental framework it is intended as a systems analysis of the impact of a capitation financing experiment on Medicaid mental health clients: especially the CMI and ..
  67. NIDDK BIOTECHNOLOGY CENTER AT THE UNIVERSITY OF FLORIDA
    Jin Xiong She; Fiscal Year: 2002
    ..to researchers, the paradigm of analyzing a single gene effect in a biological system has shifted to a global systems analysis. New high-throughput technologies have created unparalleled opportunities to study the mechanism of diseases, ..
  68. Surveillance, Analysis, and Interventions to Improve Pa*
    Victoria Fraser; Fiscal Year: 2003
    ..using critical incident analysis, root cause analysis, epidemiologic methods, and organizational and systems analysis to determine factors associated with errors...
  69. Systems analysis of oxygen regulation in Halobacterium
    AMY SCHMID; Fiscal Year: 2007
    ..These proposed experiments are expected to result in a transcriptional network model that addresses how organisms maintain homeostasis despite stress. [unreadable] [unreadable] [unreadable]..
  70. COMPUTER ANALYSIS OF AGING IN DICTYOSTELIUM
    Barbara Wright; Fiscal Year: 1992
    ..understanding of the biochemical mechanisms responsible for differentiation and aging must be sought using a SYSTEMS analysis, at a level of complexity and integration much greater than that encompassed by any theory thus far ..
  71. Low-cost digital x-ray detectors using liquid crystals
    John Rowlands; Fiscal Year: 2007
    ..This visible image is then readout optically by a digital camera. The Methods to be used are linear systems analysis, Monte Carlo simulation, detective quantum efficiency (DQE) measurement, phantom tests, as well as comparison ..
  72. SYSTEMS ANALYSIS OF BARORECEPTOR REFLEX
    Artin Shoukas; Fiscal Year: 1992
    ..As in Part A, the two mechanisms are removed sequentially and their separate and interactive contributions quantified. Plasma level of AVP and renin activity are measured and correlated with arterial pressure change...
  73. Acquisition of a 600-MHz Nuclear Magnetic Resonance Spectrometer
    JAMES GLOER; Fiscal Year: 2009
    ..Projects dedicated to improving our molecular level understanding of muscular dystrophy, Parkinson's disease, and asthma, as well as the toxicology of environmental pollutants will also benefit from access to this instrument. ..