publication bias

Summary

Summary: The influence of study results on the chances of publication and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc.

Top Publications

  1. ncbi Selective publication of antidepressant trials and its influence on apparent efficacy
    Erick H Turner
    Department of Psychiatry, Oregon Health and Science University, Portland, OR, USA
    N Engl J Med 358:252-60. 2008
  2. ncbi Comparison of two methods to detect publication bias in meta-analysis
    Jaime L Peters
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, England
    JAMA 295:676-80. 2006
  3. pmc Systematic review of the empirical evidence of study publication bias and outcome reporting bias
    Kerry Dwan
    Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 3:e3081. 2008
  4. ncbi The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed
    Jonathan J Deeks
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, New South Wales 2006, Australia
    J Clin Epidemiol 58:882-93. 2005
  5. ncbi A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints
    Roger M Harbord
    MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, UK
    Stat Med 25:3443-57. 2006
  6. pmc Effects of common polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on cancer susceptibility: a meta-analysis
    Wei Xu
    Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    PLoS ONE 6:e20471. 2011
  7. pmc Publication bias in reports of animal stroke studies leads to major overstatement of efficacy
    Emily S Sena
    Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 8:e1000344. 2010
  8. ncbi A comparison of methods to detect publication bias in meta-analysis
    P Macaskill
    Department of Public Health and Community Medicine, University of Sydney, NSW, Australia 2006
    Stat Med 20:641-54. 2001
  9. ncbi GRADE guidelines: 5. Rating the quality of evidence--publication bias
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:1277-82. 2011
  10. pmc Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials
    Dirk Eyding
    German Cancer Society, Berlin, Germany
    BMJ 341:c4737. 2010

Detail Information

Publications265 found, 100 shown here

  1. ncbi Selective publication of antidepressant trials and its influence on apparent efficacy
    Erick H Turner
    Department of Psychiatry, Oregon Health and Science University, Portland, OR, USA
    N Engl J Med 358:252-60. 2008
    ..Selective publication of clinical trials--and the outcomes within those trials--can lead to unrealistic estimates of drug effectiveness and alter the apparent risk-benefit ratio...
  2. ncbi Comparison of two methods to detect publication bias in meta-analysis
    Jaime L Peters
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, England
    JAMA 295:676-80. 2006
    Egger's regression test is often used to help detect publication bias in meta-analyses...
  3. pmc Systematic review of the empirical evidence of study publication bias and outcome reporting bias
    Kerry Dwan
    Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 3:e3081. 2008
    ..Study publication bias has been recognised as a potential threat to the validity of meta-analysis and can make the readily available ..
  4. ncbi The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed
    Jonathan J Deeks
    Screening and Test Evaluation Program, School of Public Health, University of Sydney, Sydney, New South Wales 2006, Australia
    J Clin Epidemiol 58:882-93. 2005
    b>Publication bias and other sample size effects are issues for meta-analyses of test accuracy, as for randomized trials...
  5. ncbi A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints
    Roger M Harbord
    MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, UK
    Stat Med 25:3443-57. 2006
    b>Publication bias and related bias in meta-analysis is often examined by visually checking for asymmetry in funnel plots of treatment effect against its standard error...
  6. pmc Effects of common polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on cancer susceptibility: a meta-analysis
    Wei Xu
    Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    PLoS ONE 6:e20471. 2011
    ..Rs11614913 in miR-196a2 and rs2910164 in miR-146a are shown to associate with increased/decreased cancer risk. We performed a meta-analysis to systematically summarize the possible association...
  7. pmc Publication bias in reports of animal stroke studies leads to major overstatement of efficacy
    Emily S Sena
    Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 8:e1000344. 2010
    ..The existence and any impact of such "publication bias" in the laboratory sciences have not been described...
  8. ncbi A comparison of methods to detect publication bias in meta-analysis
    P Macaskill
    Department of Public Health and Community Medicine, University of Sydney, NSW, Australia 2006
    Stat Med 20:641-54. 2001
    Meta-analyses are subject to bias for many of reasons, including publication bias. Asymmetry in a funnel plot of study size against treatment effect is often used to identify such bias...
  9. ncbi GRADE guidelines: 5. Rating the quality of evidence--publication bias
    Gordon H Guyatt
    Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Clin Epidemiol 64:1277-82. 2011
    ..as low-quality evidence, but both can be rated down if a body of evidence is associated with a high risk of publication bias. Even when individual studies included in best-evidence summaries have a low risk of bias, publication bias ..
  10. pmc Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials
    Dirk Eyding
    German Cancer Society, Berlin, Germany
    BMJ 341:c4737. 2010
    To assess the benefits and harms of reboxetine versus placebo or selective serotonin reuptake inhibitors (SSRIs) in the acute treatment of depression, and to measure the impact of potential publication bias in trials of reboxetine.
  11. ncbi Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology
    John Attia
    Centre for Clinical Epidemiology and Biostatistics, Faculty of Health, University of Newcastle, Royal Newcastle Hospital, David Maddison Building, Newcastle NSW 2300, Australia
    J Clin Epidemiol 56:297-303. 2003
    ..Heterogeneity was assessed in 28 (76%), but only 7 of 37 (19%) studies checked for publication bias. Nine (24%) studies assessed the goodness-of-fit of Hardy-Weinberg equilibrium, and eight (22%) gave any ..
  12. pmc Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications
    Hans Melander
    Medical Products Agency, Box 23, S 751 03 Uppsala, Sweden
    BMJ 326:1171-3. 2003
    To investigate the relative impact on publication bias caused by multiple publication, selective publication, and selective reporting in studies sponsored by pharmaceutical companies.
  13. ncbi Assessment of publication bias, selection bias, and unavailable data in meta-analyses using individual participant data: a database survey
    Ikhlaaq Ahmed
    MRC Midlands Hub for Trials Methodology Research, School of Health and Population Sciences, University of Birmingham, Birmingham B15 2TT, UK
    BMJ 344:d7762. 2012
    To examine the potential for publication bias, data availability bias, and reviewer selection bias in recently published meta-analyses that use individual participant data and to investigate whether authors of such meta-analyses seemed ..
  14. ncbi Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry
    Jaime L Peters
    Department of Health Sciences, University of Leicester, Leicester, UK
    J Clin Epidemiol 61:991-6. 2008
    To present the contour-enhanced funnel plot as an aid to differentiating asymmetry due to publication bias from that due to other factors.
  15. pmc Outcome reporting among drug trials registered in ClinicalTrials.gov
    Florence T Bourgeois
    Division of Emergency Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Ann Intern Med 153:158-66. 2010
    ..Clinical trial registries are in widespread use to promote transparency around trials and their results...
  16. ncbi Direction and impact of language bias in meta-analyses of controlled trials: empirical study
    Peter Juni
    Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, UK
    Int J Epidemiol 31:115-23. 2002
    ..We examined the influence of trials published in languages other than English on combined estimates and conclusions of published meta-analyses...
  17. ncbi The association between common genetic variant of microRNA-146a and cancer susceptibility
    Li Xin Qiu
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Cytokine 56:695-8. 2011
    ..Despite some limitations, this meta-analysis suggests that the miR-146a G allele is a low-penetrant risk factor for papillary thyroid carcinoma development...
  18. pmc The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey
    John P A Ioannidis
    Tufts University School of Medicine, Boston, Mass, USA
    CMAJ 176:1091-6. 2007
    ..Inappropriate application can generate misleading inferences about publication bias. We aimed to measure, in a survey of meta-analyses, how frequently the application of these tests would be ..
  19. ncbi Pooling of animal experimental data reveals influence of study design and publication bias
    Malcolm R Macleod
    National Stroke Research Institute, Melbourne, Australia
    Stroke 35:1203-8. 2004
    ..To our knowledge, such assessments have not been made. Nicotinamide is a candidate neuroprotective drug with efficacy in experimental stroke, but the limits to and characteristics of that efficacy have not been fully described...
  20. ncbi How can we improve the pre-clinical development of drugs for stroke?
    Emily Sena
    Department of Clinical Neurosciences, University of Edinburgh, UK
    Trends Neurosci 30:433-9. 2007
    ..We believe the adoption of these standards will lead to improved effectiveness and efficiency in the selection of drugs for clinical trials in stroke and in the design of those trials...
  21. ncbi Comparison of registered and published primary outcomes in randomized controlled trials
    Sylvain Mathieu
    INSERM, U738, Assistance Publique des Hopitaux de Paris, Hopital Bichat Claude Bernard, Département d Epidémiologie Biostatistique et Recherche Clinique, Paris, France
    JAMA 302:977-84. 2009
    ..As of 2005, the International Committee of Medical Journal Editors required investigators to register their trials prior to participant enrollment as a precondition for publishing the trial's findings in member journals...
  22. pmc Systematic review of the empirical evidence of study publication bias and outcome reporting bias - an updated review
    Kerry Dwan
    Department of Biostatistics, University of Liverpool, Liverpool, England
    PLoS ONE 8:e66844. 2013
    ..Study publication bias and outcome reporting bias have been recognised as a potential threat to the validity of meta-analysis and ..
  23. ncbi Preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and publication bias
    Karsten Knobloch
    Plastic, Hand and Reconstructive Surgery, Hannover Medical School, Germany
    J Craniomaxillofac Surg 39:91-2. 2011
    b>Publication bias is a major problem in evidence based medicine...
  24. pmc Reporting bias in drug trials submitted to the Food and Drug Administration: review of publication and presentation
    Kristin Rising
    School of Medicine, University of California San Francisco, San Francisco, California, USA
    PLoS Med 5:e217; discussion e217. 2008
    ....
  25. ncbi Selective reporting biases in cancer prognostic factor studies
    Panayiotis A Kyzas
    Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece
    J Natl Cancer Inst 97:1043-55. 2005
    ..We probed these biases in a meta-analysis of a prognostic factor for head and neck squamous cell cancer (HNSCC) mortality that has drawn wide attention--the status of the tumor suppressor protein TP53...
  26. pmc Fate of biomedical research protocols and publication bias in France: retrospective cohort study
    Evelyne Decullier
    Clinical Research Unit, DIM des Hospices Civils de Lyon, 162 Avenue Lacassagne, 69424 Lyon Cedex 03, France
    BMJ 331:19. 2005
    To describe the fate of protocols approved by the French research ethics committees, a national system created by the French 1988 Huriet-Sérusclat Act; to assess publication bias at a national level.
  27. ncbi Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case-control studies
    Jun Wang
    Department of Oncology, General Hospital, Jinan Command of the People s Liberation Army, Shifan Street 25, Tianqiao District, Jinan, 250031, China
    Mol Biol Rep 39:4571-9. 2012
    ..However, further well-designed studies with large sample size will be necessary to validate the risk identified in the current meta-analysis...
  28. pmc "Hardly worth the effort"? Medical journals' policies and their editors' and publishers' views on trial registration and publication bias: quantitative and qualitative study
    Elizabeth Wager
    Sideview, Princes Risborough, Bucks HP27 9DE, UK
    BMJ 347:f5248. 2013
    To determine the proportion of medical journals requiring trial registration and to understand their reasons for adopting (or not adopting) such policies and other measures designed to reduce publication bias.
  29. ncbi Arcsine test for publication bias in meta-analyses with binary outcomes
    Gerta Rucker
    Institute of Medical Biometry and Medical Informatics, University Medical Centre, Freiburg, Germany
    Stat Med 27:746-63. 2008
    ..One possible reason for such 'small study effects' is publication bias. This is said to occur when the chance of a smaller study being published is increased if it shows a stronger ..
  30. pmc Publication bias in antipsychotic trials: an analysis of efficacy comparing the published literature to the US Food and Drug Administration database
    Erick H Turner
    Department of Psychiatry, Oregon Health and Science University, Portland, Oregon, USA
    PLoS Med 9:e1001189. 2012
    b>Publication bias compromises the validity of evidence-based medicine, yet a growing body of research shows that this problem is widespread. Efficacy data from drug regulatory agencies, e.g...
  31. ncbi Outcome reporting in industry-sponsored trials of gabapentin for off-label use
    S Swaroop Vedula
    Center for Clinical Trials, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    N Engl J Med 361:1963-71. 2009
    ..There is good evidence of selective outcome reporting in published reports of randomized trials...
  32. pmc Impact of reporting bias in network meta-analysis of antidepressant placebo-controlled trials
    Ludovic Trinquart
    French Cochrane Centre, Paris, France
    PLoS ONE 7:e35219. 2012
    ..Indirect comparisons of competing treatments by network meta-analysis (NMA) are increasingly in use. Reporting bias has received little attention in this context. We aimed to assess the impact of such bias in NMAs...
  33. pmc Factors associated with findings of published trials of drug-drug comparisons: why some statins appear more efficacious than others
    Lisa Bero
    Clinical Pharmacy and Health Policy, University of California, San Francisco, California, United States of America
    PLoS Med 4:e184. 2007
    ....
  34. pmc Reporting bias in medical research - a narrative review
    Natalie McGauran
    Institute for Quality and Efficiency in Health Care, Dillenburger Str 27, 51105 Cologne, Germany
    Trials 11:37. 2010
    ..aim of this narrative review is to gain an overview of reporting bias in the medical literature, focussing on publication bias and selective outcome reporting...
  35. ncbi Performance of the trim and fill method in the presence of publication bias and between-study heterogeneity
    Jaime L Peters
    Department of Health Sciences, University of Leicester, Leicester LE1 7RH, U K
    Stat Med 26:4544-62. 2007
    The trim and fill method allows estimation of an adjusted meta-analysis estimate in the presence of publication bias. To date, the performance of the trim and fill method has had little assessment...
  36. ncbi Assessing publication bias in genetic association studies: evidence from a recent meta-analysis
    Marcus R Munafo
    Department of Clinical Pharmacology, Cancer Research UK, General Practice Research Group, University of Oxford, Oxford OX2 6HE, UK
    Psychiatry Res 129:39-44. 2004
    b>Publication bias may exist when nonsignificant findings remain unpublished, thereby artificially inflating the apparent magnitude of an effect...
  37. ncbi Too good to be true: publication bias in two prominent studies from experimental psychology
    Gregory Francis
    Department of Psychological Sciences, Purdue University, West Lafayette, IN, USA
    Psychon Bull Rev 19:151-6. 2012
    ..the final arbiter of phenomena in science, but replication is undermined when there is evidence for publication bias. Evidence for publication bias in a set of experiments can be found when the observed number of rejections of ..
  38. pmc Impact of funding on biomedical research: a retrospective cohort study
    Evelyne Decullier
    Clinical Epidemiology Unit DIM Hospices Civils de Lyon, Lyon, France
    BMC Public Health 6:165. 2006
    ....
  39. ncbi Journal prestige, publication bias, and other characteristics associated with citation of published studies in peer-reviewed journals
    Michael Callaham
    Division of Emergency Medicine, University of California, San Francisco, CA 94143 0208, USA
    JAMA 287:2847-50. 2002
    ..Citation by other authors is important in the dissemination of published science, but factors predicting it are little studied...
  40. ncbi miR-196a2 C allele is a low-penetrant risk factor for cancer development
    Li Xin Qiu
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Cytokine 56:589-92. 2011
    ..TT: OR=1.19, 95% CI=1.06-1.35; dominant model: OR=1.13, 95% CI=1.01-1.25). Despite some limitations, this meta-analysis suggests that the miR-196a2 C allele is a low-penetrant risk factor for cancer development...
  41. ncbi Associations between asymmetry and human attractiveness: Possible direct effects of asymmetry and signatures of publication bias
    Stefan Van Dongen
    Group of Evolutionary Ecology, University of Antwerp, Groenenborgerlaan 171, B 2020, Antwerp, Belgium
    Ann Hum Biol 38:317-23. 2011
    ..The evolutionary importance of these associations, however, critically depends on the role of DI in driving these correlations. A direct effect of FA reduces the role of DI...
  42. ncbi Publication bias and time-trend bias in meta-analysis of bicycle helmet efficacy: a re-analysis of Attewell, Glase and McFadden, 2001
    Rune Elvik
    Institute of Transport Economics, Gaustadalleen 21, NO 0349 Oslo, Norway
    Accid Anal Prev 43:1245-51. 2011
    ..reported by Attewell, Glase, and McFadden (Accident Analysis and Prevention 2001, 345-352) was influenced by publication bias and time-trend bias that was not controlled for...
  43. pmc Lack of association of two common polymorphisms rs2910164 and rs11614913 with susceptibility to hepatocellular carcinoma: a meta-analysis
    Zhongxia Wang
    Department of Hepatobiliary Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu Province, China
    PLoS ONE 7:e40039. 2012
    ..However, published results are inconsistent and inconclusive. In the present study, we performed a meta-analysis to systematically summarize the possible association between the two SNPs and the risk for HCC...
  44. ncbi Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy
    Fujian Song
    Department of Public Health and Epidemiology, University of Birmingham, Edgbaston, UK
    Int J Epidemiol 31:88-95. 2002
    Despite the great possibility of publication bias in studies of diagnostic test research, empirical studies about publication bias have mainly focused on studies of treatment effect.
  45. pmc Extent of publication bias in different categories of research cohorts: a meta-analysis of empirical studies
    Fujian Song
    School of Medicine, Health Policy and Practice, University of East Anglia, Earlham Road, Norwich NR4 7TJ, UK
    BMC Med Res Methodol 9:79. 2009
    ..We conducted a meta-analysis to ascertain the strength and consistency of the association between study results and formal publication...
  46. ncbi Why olanzapine beats risperidone, risperidone beats quetiapine, and quetiapine beats olanzapine: an exploratory analysis of head-to-head comparison studies of second-generation antipsychotics
    Stephan Heres
    Klinik und Poliklinik für Psychiatrie und Psychotherapie der Technischen Universität München am Klinikum rechts der Isar, Moehlstrasse 26, 81675 Munich, Germany
    Am J Psychiatry 163:185-94. 2006
    ....
  47. ncbi Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles
    An Wen Chan
    Centre for Statistics in Medicine, Institute of Health Sciences, Headington, Oxford, England
    JAMA 291:2457-65. 2004
    ..Selective reporting of outcomes within published studies based on the nature or direction of their results has been widely suspected, but direct evidence of such bias is currently limited to case reports...
  48. ncbi Obstacles and opportunities in meta-analysis of genetic association studies
    Georgia Salanti
    MRC Biostatistics Unit, Cambridge, UK
    Genet Med 7:13-20. 2005
    ..We believe that systematic review and meta-analysis has an important role to play in understanding genetic association studies and should help us to separate the wheat from the chaff...
  49. pmc Assessment of regression-based methods to adjust for publication bias through a comprehensive simulation study
    Santiago G Moreno
    Department of Health Sciences, University of Leicester, Leicester, UK
    BMC Med Res Methodol 9:2. 2009
    ..This issue potentially mean inappropriate conclusions are drawn from a meta-analysis. If meta-analysis is to be used to inform decision-making, a reliable way to adjust pooled estimates for potential funnel plot asymmetry is required...
  50. pmc Increased risk of breast cancer associated with CC genotype of Has-miR-146a Rs2910164 polymorphism in Europeans
    Hai Lian
    Department of Pathology, The Eleventh Institute of Academy of Military Medical Sciences, Changchun, China
    PLoS ONE 7:e31615. 2012
    ..However, the results remain conflicting rather than conclusive...
  51. pmc Evaluating the quality of research into a single prognostic biomarker: a systematic review and meta-analysis of 83 studies of C-reactive protein in stable coronary artery disease
    Harry Hemingway
    Department of Epidemiology and Public Health, University College London, United Kingdom
    PLoS Med 7:e1000286. 2010
    ..We sought to evaluate the quality of prognostic research evidence for the association of C-reactive protein (CRP) with fatal and nonfatal events among patients with stable coronary disease...
  52. ncbi Systematic evaluation and comparison of statistical tests for publication bias
    Yasuaki Hayashino
    Department of Epidemiology and Healthcare Research, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto, Japan
    J Epidemiol 15:235-43. 2005
    This study evaluates the statistical and discriminatory powers of three statistical test methods (Begg's, Egger's, and Macaskill's) to detect publication bias in meta-analyses.
  53. ncbi Capture-recapture is a potentially useful method for assessing publication bias
    Derrick A Bennett
    The Clinical Trials Research Unit, 3 Ferncroft Street, Grafton, Faculty of Medicine and Health Sciences, Private Bag 92019, University of Auckland, New Zealand
    J Clin Epidemiol 57:349-57. 2004
    b>Publication bias is a problem in systematic reviews of randomized controlled trials...
  54. ncbi What are the implications of optimism bias in clinical research?
    Iain Chalmers
    James Lind Library, Summertown Pavilion, Oxford OX2 7LG, UK
    Lancet 367:449-50. 2006
  55. ncbi Publication bias, with a focus on psychiatry: causes and solutions
    Erick H Turner
    Behavioral Health and Neurosciences Division, Portland Veterans Affairs Medical Center, P3MHDC, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, USA
    CNS Drugs 27:457-68. 2013
    b>Publication bias undermines the integrity of the evidence base by inflating apparent drug efficacy and minimizing drug harms, thus skewing the risk-benefit ratio...
  56. ncbi Publication bias in psychological science: prevalence, methods for identifying and controlling, and implications for the use of meta-analyses
    Christopher J Ferguson
    Department of Psychology, Texas A and M International University, 5201 University Blvd, Laredo, TX 78041, USA
    Psychol Methods 17:120-8. 2012
    The issue of publication bias in psychological science is one that has remained difficult to address despite decades of discussion and debate...
  57. ncbi Systematic reviews and meta-analyses of preclinical studies: publication bias in laboratory animal experiments
    D A Korevaar
    Department of General Practice, Academic Medical Center AMC, University of Amsterdam UvA, PO Box 22700, 1100 DD Amsterdam, The Netherlands
    Lab Anim 45:225-30. 2011
    ..They found 46 LAE meta-analyses (MAs), often of poor quality. Six of these 46 MAs tried to assess publication bias. Publication bias is the phenomenon of an experiment's results determining its likelihood of publication, ..
  58. ncbi Searching for unpublished trials in Cochrane reviews may not be worth the effort
    Mieke L Van Driel
    Department of General Practice and Primary Health Care, Ghent University, Belgium
    J Clin Epidemiol 62:838-844.e3. 2009
    ..To assess the value of searching for unpublished data by exploring the extent to which Cochrane reviews include unpublished data and by evaluating the quality of unpublished trials...
  59. ncbi Inflation of type I error rate in two statistical tests for the detection of publication bias in meta-analyses with binary outcomes
    Guido Schwarzer
    Freiburg Center for Data Analysis and Modelling, University of Freiburg, Germany
    Stat Med 21:2465-77. 2002
    ..The validity of a meta-analysis may be affected by various sources of bias (for example, publication bias, language bias). Therefore, an analysis of bias should be an integral part of any systematic review...
  60. ncbi Publication bias and the failure of replication in experimental psychology
    Gregory Francis
    Department of Psychological Sciences, Purdue University, 703 Third Street, West Lafayette, IN 47906, USA
    Psychon Bull Rev 19:975-91. 2012
    ..Rather than strengthen confidence in an effect, too much successful replication actually indicates publication bias, which invalidates entire sets of experimental findings...
  61. pmc Effects of fish oil supplementation on inflammatory markers in chronic heart failure: a meta-analysis of randomized controlled trials
    Wei Xin
    First Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, Peoples Republic of China
    BMC Cardiovasc Disord 12:77. 2012
    ..In this meta-analysis, we aimed to evaluate the influence of fish oil supplementation on circulating levels of inflammatory markers in patients with chronic heart failure...
  62. ncbi A meta-analysis of tumor necrosis factor-alpha, interleukin-6, and interleukin-10 in preeclampsia
    Cui Xie
    Central Laboratory and Center of Prenatal Diagnosis, Shenzhen Baoan Maternal and Child Health Hospital, Shenzhen, People s Republic of China
    Cytokine 56:550-9. 2011
    ..Our findings strengthen the clinical evidence that PE is accompanied by exaggerated inflammatory responses, but do not support TNF-α-308G/A, IL-6-174G/C, and IL-10-1082A/G as candidate susceptibility loci in PE...
  63. ncbi Detecting and adjusting for small-study effects in meta-analysis
    Gerta Rucker
    Institute of Medical Biometry and Medical Informatics, University Medical Center, Stefan Meier Strasse 26, D 79104 Freiburg, Germany
    Biom J 53:351-68. 2011
    b>Publication bias and related types of small-study effects threaten the validity of systematic reviews. The existence of small-study effects has been demonstrated in empirical studies...
  64. ncbi MDM2 SNP309 polymorphism and breast cancer risk: a meta-analysis
    Erjiang Zhao
    Department of Epidemiology and Biostatistics, Public Health School of Zhengzhou University, Zhengzhou, 450001, China
    Mol Biol Rep 39:3471-7. 2012
    ..TT (OR = 1.26, 95% CI = 0.84-1.87). Our meta-analysis suggests that MDM2 SNP309 polymorphism may increase the risk to breast cancer in Asian and African population...
  65. ncbi The Arg194Trp polymorphism in the XRCC1 gene and cancer risk in Chinese Mainland population: a meta-analysis
    Jin Huang
    West China Hospital West China Medical School, Sichuan University, Chengdu, Sichuan, China
    Mol Biol Rep 38:4565-73. 2011
    ..More intensive and deeper studies are needed to further reveal the mechanism between Arg194Trp polymorphisms of XRCC1 gene and cancer risks in Chinese Mainland population...
  66. pmc X-ray repair cross-complementing group 1 polymorphisms and hepatocellular carcinoma: a meta-analysis
    Tian Xie
    Department of Hepatic Surgery, National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Central South University, Changsha 410008, Hunan Province, China
    World J Gastroenterol 18:4207-14. 2012
    ..To perform a systematic meta-analysis to investigate the association between X-ray repair cross-complementing group 1 (XRCC1) polymorphisms and hepatocellular carcinoma (HCC) risk...
  67. pmc Protocol for a systematic review on the extent of non-publication of research studies and associated study characteristics
    Susan Portalupi
    German Cochrane Centre, Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Freiburg, Germany
    Syst Rev 2:2. 2013
    ..that non-published studies often have different results than those that are published, a phenomenon known as publication bias. When results are not published, or are published selectively based on the direction or the strength of the ..
  68. ncbi Publication bias and outcome reporting bias: agomelatine as a case example
    Robert H Howland
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    J Psychosoc Nurs Ment Health Serv 49:11-4. 2011
    b>Publication bias and outcome reporting bias contribute to distorted perceptions of drug efficacy and the underreporting of adverse events...
  69. ncbi Meta-analysis of genetic studies from journals published in China of ischemic stroke in the Han Chinese population
    Xiaowei Xu
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, People s Republic of China
    Cerebrovasc Dis 26:48-62. 2008
    ..The aim of this study was to confirm the nature and number of genes contributing to stroke risk and qualify the genetic risk of each susceptibility gene in the Han Chinese population...
  70. ncbi Excess significance bias in the literature on brain volume abnormalities
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina, Greece
    Arch Gen Psychiatry 68:773-80. 2011
    ..Many studies report volume abnormalities in diverse brain structures in patients with various mental health conditions...
  71. ncbi Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    Kirk E Lohmueller
    Whitehead Massachuetts Institute of Technology Center for Genome Research, Cambridge, Massachusetts 02139, USA
    Nat Genet 33:177-82. 2003
    ..This excess of replications could not be reasonably explained by publication bias and was concentrated among 11 of the 25 associations...
  72. ncbi Efficacy of cognitive-behavioural therapy and other psychological treatments for adult depression: meta-analytic study of publication bias
    Pim Cuijpers
    Department of Clinical Psychology, VU University Amsterdam, Van der Boechorststraat 1, Amsterdam, The Netherlands
    Br J Psychiatry 196:173-8. 2010
    It is not clear whether the effects of cognitive-behavioural therapy and other psychotherapies have been overestimated because of publication bias.
  73. pmc Do pressures to publish increase scientists' bias? An empirical support from US States Data
    Daniele Fanelli
    INNOGEN and Institute for the Study of Science, Technology and Innovation, The University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e10271. 2010
    ..The same phenomenon might be observed in other countries where academic competition and pressures to publish are high...
  74. ncbi Modelling publication bias in meta-analysis: a review
    A J Sutton
    Department of Epidemiology and Public Health, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Stat Methods Med Res 9:421-45. 2000
    Meta-analysis is now a widely used technique for summarizing evidence from multiple studies. Publication bias, the bias induced by the fact that research with statistically significant results is potentially more likely to be submitted ..
  75. ncbi Updated systematic review and meta-analysis of the effects of n-3 long-chain polyunsaturated fatty acids on depressed mood
    Katherine M Appleton
    School of Psychology, Queen s University, Belfast, UK
    Am J Clin Nutr 91:757-70. 2010
    ..The debate over a role for n-3 long-chain polyunsaturated fatty acids (n-3 PUFAs) in depressed mood continues...
  76. ncbi Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case-control studies and evidence of publication bias
    M R Munafò
    Department of Experimental Psychology, University of Bristol, Bristol, UK
    Mol Psychiatry 12:454-61. 2007
    ..and alcoholism, using meta-analytic techniques, and specifically undertook an investigation of possible publication bias. Potential publication bias represents a genuine risk to the integrity of published research, but its impact ..
  77. pmc Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development
    James F Fries
    Stanford University School of Medicine, Palo Alto, California, USA
    Arthritis Res Ther 6:R250-5. 2004
    ..0001). Equipoise clearly was being systematically violated. Publication bias appeared to be an incomplete explanation for this dramatic result; this bias occurs after a study is ..
  78. ncbi Almost all articles on cancer prognostic markers report statistically significant results
    Panayiotis A Kyzas
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Eur J Cancer 43:2559-79. 2007
    ..Under strong reporting bias, statistical significance loses its discriminating ability for the importance of prognostic markers...
  79. ncbi Delay and failure to publish dental research
    J M Scholey
    Department of Clinical Dental Sciences, Liverpool University Dental Hospital and School of Dentistry, Pembroke Place, Liverpool L3 5PS
    Evid Based Dent 6:58-61. 2005
    ..To investigate the incidence and time taken to full publication of abstracts presented at dental scientific meetings...
  80. pmc Cigarette smoking and p16INK4α gene promoter hypermethylation in non-small cell lung carcinoma patients: a meta-analysis
    Bo Zhang
    Department of Toxicology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat Sen University, Guangzhou, China
    PLoS ONE 6:e28882. 2011
    ..Recently, many studies have investigated the association between cigarette smoking and p16(INK4α) gene hypermethylation in lung cancer, but could not reach a unanimous conclusion...
  81. ncbi The role of conflict of interest in reporting of scientific information
    Richard S Irwin
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Chest 136:253-9. 2009
    ....
  82. ncbi A meta-analysis of CDH1 C-160A genetic polymorphism and gastric cancer risk
    Yun Cui
    Department of Gastroenterology, Renji Hospital, Shanghai Institute of Gastrointestinal Diseases, Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
    DNA Cell Biol 30:937-45. 2011
    ..Genotyping techniques, sample size, quality appraisal scores, or article publication time did not constitute the source of heterogeneity across studies; and no publication biases were found in our meta-analysis...
  83. ncbi The association between MLH1 -93 G>A polymorphism of DNA mismatch repair and cancer susceptibility: a meta-analysis
    Xin min Pan
    Department of Forensic Pathology, College of Forensic Medicine, Henan University of Science and Technology, 31 Anhui Road, Jianxi District, Luoyang, Henan 471003, People s Republic of China
    Mutagenesis 26:667-73. 2011
    ..On the conservative standpoint, well-designed population-based studies with larger sample size in different ethnic groups should be performed to further confirm these results...
  84. ncbi Adjusting for publication biases across similar interventions performed well when compared with gold standard data
    Santiago G Moreno
    Department of Evaluation of Innovation and New Technologies, Fundació Clínic, C Urgell 216, baixos, Barcelona 08036, Spain
    J Clin Epidemiol 64:1230-41. 2011
    ..To extend, apply, and evaluate a regression-based approach to adjusting meta-analysis for publication and related biases. The approach uses related meta-analyses to improve estimation by borrowing strength on the degree of bias...
  85. ncbi Industry support and correlation to study outcome for papers published in Spine
    Rahul V Shah
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut, USA
    Spine (Phila Pa 1976) 30:1099-104; discussion 1105. 2005
    ..Retrospective review of articles published in the journal Spine...
  86. ncbi Modelling multiple sources of dissemination bias in meta-analysis
    Jack Bowden
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, U K
    Stat Med 29:945-55. 2010
    ..This may be caused by publication bias through the decisions of journal editors, by selective reporting of research results by authors or by a ..
  87. ncbi A case study of publication bias in an influential series of reviews of drug education
    Jim McCambridge
    Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, Centre for Research on Drugs and Health Behaviour, London, UK
    Drug Alcohol Rev 26:463-8. 2007
    There has been remarkably little demonstration of the deleterious impact of publication bias within addiction science or indeed in wider healthcare policy and practice...
  88. ncbi Reporting research results: a moral obligation for all researchers
    David Moher
    Can J Anaesth 54:331-5. 2007
  89. ncbi More than numbers: the power of graphs in meta-analysis
    Leon Bax
    Kitasato Clinical Research Center, Kitasato University, Sagamihara, Kanagawa, Japan
    Am J Epidemiol 169:249-55. 2009
    ..the assessment of graphs is widely used in an attempt to identify or rule out heterogeneity and publication bias. A variety of graphs are available for this purpose...
  90. ncbi Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias
    Tiago V Pereira
    Heart Institute InCor, Sao Paulo University Medical School, University of Sao Paulo, Brazil
    J Hypertens 25:1763-74. 2007
    ..To explore this hypothesis further, we performed a meta-analysis and re-evaluated the relationship between the three most widely studied NOS3 polymorphisms and hypertension status and blood pressure levels...
  91. ncbi Assessment of risk of bias among pediatric randomized controlled trials
    Michael T Crocetti
    Department of Pediatrics, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
    Pediatrics 126:298-305. 2010
    ..The goal was to assess the risk of bias among pediatric, randomized, controlled trials (RCTs) reported in 8 high-impact journals...
  92. ncbi Dissemination and publication of research findings: an updated review of related biases
    F Song
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    Health Technol Assess 14:iii, ix-xi, 1-193. 2010
    ....
  93. ncbi -765G>C and 8473T>C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case-control studies
    Wei Zhu
    Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Mol Biol Rep 37:277-88. 2010
    ..In summary, this meta-analysis suggesting that -765G>C may cause an increased risk of colorectal carcinoma and esophageal cancer in Asian descents while 8473T>C polymorphism may cause a decreased risk of breast and lung cancer...
  94. pmc Reporting the findings of clinical trials: a discussion paper
    D Ghersi
    World Health Organization, Geneva, Switzerland
    Bull World Health Organ 86:492-3. 2008
  95. ncbi N-acetylcysteine in the prevention of contrast-induced nephropathy: publication bias perpetuated by meta-analyses
    Paul T Vaitkus
    Cardiology Division, M C 715, University of Illinois at Chicago, Chicago, IL 60612, USA
    Am Heart J 153:275-80. 2007
    ..We sought to examine the possibility of a publication bias and whether meta-analyses have magnified any potential publication bias.
  96. ncbi Publication bias in epidemiological studies
    Nazish Siddiqi
    Department of Epidemiology, Michigan State University, East Lansing, Michigan, USA
    Cent Eur J Public Health 19:118-20. 2011
    Communication of research findings is the utmost responsibility of all scientists. Publication bias occurs if scientific studies with negative or null results fail to get published...
  97. ncbi Effect of reporting bias on meta-analyses of drug trials: reanalysis of meta-analyses
    BETH HART
    Department of Clinical Pharmacy, Institute for Health Policy Studies, University of California, San Francisco, 3333 California St, Suite 420, San Francisco, CA 94118, USA
    BMJ 344:d7202. 2012
    ..To investigate the effect of including unpublished trial outcome data obtained from the Food and Drug Administration (FDA) on the results of meta-analyses of drug trials...
  98. pmc Time-lag bias in trials of pediatric antidepressants: a systematic review and meta-analysis
    Magdalena M Reyes
    Yale Child Study Center, Yale University School of Medicine, 230 South Frontage Road, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 50:63-72. 2011
    ..To determine whether there is evidence of a time-lag bias in the publication of pediatric antidepressant trials...
  99. ncbi Association between +61G polymorphism of the EGF gene and glioma risk in different ethnicities: a meta-analysis
    Dianhui Tan
    Department of Neurosurgery, First Affiliated Hospital of Shantou University Medical College, Shantou, PR China
    Tohoku J Exp Med 222:229-35. 2010
    ..14, 95%CI (1.02-1.27), P(heterogeneity) = 0.179, I² = 71.8]. In conclusion, EGF +61G allele represents a risk factor for glioma in European population and conversely a protective factor in Chinese population...
  100. pmc Research funding, conflicts of interest, and the meta-methodology of public relations
    Sheldon Rampton
    Center for Media and Democracy, Madison, WI 53703, USA
    Public Health Rep 117:331-9. 2002
  101. ncbi Issues pertaining to data extraction and classification and publication bias in meta-analysis of the diagnostic accuracy of markers for bacterial infection
    Troels Bygum Knudsen
    Clin Infect Dis 40:1372-3; author reply 1373-4. 2005

Research Grants76

  1. Exploring the Association Between Immune-Related Genetic Variation and HNSCC
    Chaya Levovitz; Fiscal Year: 2013
    ..include low statistical power in detecting modest risk sequence variants, false positive results, positive publication bias, and a moderate prior probability that each SNP individually confers substantial increase in risk14...
  2. Meta-Analysis of Interventions to Improve Medication Adherence
    Vicki S Conn; Fiscal Year: 2013
    ..magnitude of effect, sample size weighted calculations, random-effects models, homogeneity (Q) assessment, publication bias analysis (I2), and to facilitate interpretation - Common Language Effect Size and conversion to original ..
  3. Breastfeeding RCT: Adolescent Neurocognitive and Respiratory Function
    Emily Oken; Fiscal Year: 2013
    ..Existing evidence is largely based on observational studies, which are prone to measurement error, publication bias and reverse causality...
  4. Circulating Vitamin D Levels and Risk of Breast and Colorectal Cancer: a Pooled A
    Stephanie A Smith-Warner; Fiscal Year: 2013
    ..Further, new data will be generated in seven of the studies which will reduce the influence of publication bias. This proposal takes full advantage of extensive data collected throughout the world, builds upon the ..
  5. Quantifying Risk And Survival Benefit from Incompatible Kidney Transplantation
    BABAK JOHN ORANDI; Fiscal Year: 2013
    ..is limited, as the UNOS national transplant registry does not collect data on incompatibilities, and inherent publication bias limits the current paradigm...
  6. Quantifying Risk And Survival Benefit from Incompatible Kidney Transplantation
    Dorry Segev; Fiscal Year: 2013
    ..in this field, future growth is currently limited by inferences from single-center reports which suffer from publication bias, lack of statistical power, inability to compare protocol effectiveness within a single-center (because of ..
  7. Treatment Success and Ethical Principle of Equipoise
    Benjamin Djulbegovic; Fiscal Year: 2010
    ..g. improving particular methodological deficiency, correcting for publication bias etc) resulting in the immediate practical application of our research...
  8. Comparative Effectiveness & Medical Interventions for Primary Open Angle Glaucoma
    Kay Dickersin; Fiscal Year: 2010
    ..We will validate the MTC meta-analysis models and assess the impact of publication bias. We will report and disseminate our findings on the comparative effectiveness of medical interventions for ..
  9. Equipoise and the research integrity of clinical trials
    Benjamin Djulbegovic; Fiscal Year: 2003
    ..However, we could not exclude publication bias as the explanation for the higher proportion of positive results in the literature...
  10. PUBLICATION BIAS IN META ANALYSES FOR MENTAL HEALTH
    Michael Borenstein; Fiscal Year: 2003
    DESCRIPTION (Applicant's abstract): The goal of this project is to develop software to address publication bias in meta analysis...
  11. Pooled Analyses of SNPs and Risk of Head & Neck Cancer
    Mia Hashibe; Fiscal Year: 2006
    ..due to: i) low statistical power in detecting modest risk sequence variants, ii) false positive results, iii) publication bias, and iv) a moderate prior probability that each SNP individually confers substantial increase in risk...
  12. Two Methodological Problems in Psychotherapy Research
    Scott Baldwin; Fiscal Year: 2004
    ..First is publication bias. The proposed research will review psychotherapy meta-analyses to assess whether and how meta-analysts attend ..
  13. Multi-Site Longitudinal Analysis-Psychiatric Risk of SUD
    ELIZABETH COSTELLO; Fiscal Year: 2005
    ..and which depends on investigators' decision to publish on a particular topic; and it is not subject to "publication bias": the tendency to publish only "significant" findings...
  14. International Lung Cancer Consortium: Pooled analysis o*
    Paul Brennan; Fiscal Year: 2006
    ..false positive results, (iii) failure to consider effect modifiers such as environmental exposures, and (iv) publication bias. Furthermore, examining the main effects of single modest risk sequence variants is an overly simplified ..
  15. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  16. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. COST EFFECTIVENESS OF GENETIC SCREENING FOR COLON CANCER
    Scott Ramsey; Fiscal Year: 2002
    ....
  18. A Genetic Screening Policy Model for Colorectal Cancer
    Scott Ramsey; Fiscal Year: 2006
    ..The model will incorporate QOL information from Aim 2, along with family history, clinical, and screening information from the Seattle CFR. ..
  19. Pramipexole in Treatment-Resistant Depression
    Roy Perlis; Fiscal Year: 2007
    ..The proposed investigation and training program will provide critical skills, experience and data to aid the candidate in writing an R01 and becoming an independent investigator. ..
  20. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  21. DEALING WITH PUBLICATION BIAS IN META-ANALYSIS
    Norma Terrin; Fiscal Year: 2004
    ..Still, key methodological issues remain, including the problem of publication bias, which can threaten the results of any meta-analysis...
  22. Gene Expression in Inflammatory Myopathies
    Steven Greenberg; Fiscal Year: 2005
    ..This work may provide further diagnostic approaches to these disorders and contribute to the understanding of their pathogenesis. ..
  23. The Perception of Cancer Risk in Patients with Barrett's Esophagus
    Nicholas Shaheen; Fiscal Year: 2007
    ..The resultant study application will assess health-related quality of life, health-related anxiety and healthcare utilization as outcomes. [unreadable] [unreadable]..
  24. RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMA
    Edward Giovannucci; Fiscal Year: 2003
    ..abstract_text> ..
  25. Comprehensive Support for Alzheimer's Disease Caregivers
    JOSEPH GAUGLER; Fiscal Year: 2008
    ..The proposed evaluation will provide detailed information on the potential of the ECS to serve as a model intervention for various family caregivers of Alzheimer?s patients in diverse geographic contexts. [unreadable]..
  26. DIET AND GENETIC INTERACTIONS IN PROSTATE CANCER
    Edward Giovannucci; Fiscal Year: 2001
    ..The buccal brushings, along with providing the basis for the specific aims in this application, will allow for the rapid testing of future specific hypotheses. ..
  27. A Cancer Study Among Female Veterans in Texas, 1979-2001
    Sally Vernon; Fiscal Year: 2005
    ..This research will further knowledge of the health needs of women veterans, serving to identify needed health services and to guide health policy, and will provide a basis for research agendas aimed at this growing occupational cohort. ..
  28. Higher Throughput Behavioral Screening of Cognitive Enhancers
    Daniela Brunner; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  29. Early Identification of Adverse Reactions to Herbs
    Stephen Bent; Fiscal Year: 2007
    ..Ultimately, this research strives to identify improved methods for the early detection of adverse events, providing patients with a safer environment to achieve the potential benefits of herbal products. ..
  30. CVD Predictors of Cognitive Function Trajectory over 20 Years
    Elizabeth L Barrett Connor; Fiscal Year: 2010
    ..This information is important given the aging of the population, the fact that CVD risk factors are modifiable, and because the maintenance of cognitive function is an essential component of healthy aging. ..
  31. Raloxifene in Women with AD: Randomized Controlled Trial
    VICTOR HENDERSON; Fiscal Year: 2007
    ..It is anticipated that findings from this pilot study will provide useful guidance to plan and conduct future studies of raloxifene in women with mild to moderate symptoms of dementia due to AD. ..
  32. Outcomes of Sleep Disorders in Older Men
    Elizabeth Barrett Connor; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  33. Statistical Methods for Identifying Clonal Tumors
    Colin B Begg; Fiscal Year: 2011
    ....
  34. Capitalizing upon Genetic Heterogeneity
    David Redden; Fiscal Year: 2007
    ..Redden have been proposed. At the end of this five year research initiative, Dr. Redden will be well positioned to conduct cross-disciplinary research in obesity, genetics, and statistics. ..
  35. Lay and Expert Models of Gene-Environment Interaction
    Celeste Condit; Fiscal Year: 2008
    ..This will help recipients to adopt behaviors that will better stave off the risks identified by the tests. [unreadable] [unreadable] [unreadable]..
  36. Relation of Alignment and Other Risk Factors to Knee OA
    DAVID TOBIN FELSON; Fiscal Year: 2010
    ....
  37. Structural Correlates of Knee Pain
    David Felson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. Effects of Light at Night on Circadian System in Nurses
    Eva Schernhammer; Fiscal Year: 2008
    ..abstract_text> ..
  39. FONDAPARINUM IN CHILDREN WITH THROMBOSIS
    Guy Young; Fiscal Year: 2007
    ..Pharmacokinetic analyses as well as safety and efficacy determinations will be made which will provide valuable information on this new anticoagulant for pediatric patients. [unreadable] [unreadable]..
  40. EVALUATING VOUCHER-BASED CONTINGENCIES IN A DRUG COURT
    Michael Prendergast; Fiscal Year: 2003
    ..4) To provide a qualitative assessment of the impact on court operations and costs of introducing a voucher-based contingency management protocol into a drug court treatment program. ..
  41. A Method for Validating Gene - Disease Associations
    Colin Begg; Fiscal Year: 2004
    ..abstract_text> ..
  42. Comprehensive Database on Spirituality and Health
    Jeanette Ezzo; Fiscal Year: 2004
    ..Phase II will focus on comprehensively populating the database with a significantly larger and more comprehensive set of research citations and related materials and migrating to a fully functional website, SpiritLit.com. ..
  43. WOMEN VETERANS AND BREAST CANCER SCREENING
    Sally Vernon; Fiscal Year: 2003
    ..The infrastructure is in place to institutionalize the intervention should it prove to be effective. ..
  44. Chronic Illness Exercise Interventions: A Meta-Analysis
    Vicki Conn; Fiscal Year: 2004
    ..The compelling importance and broad scope of this work make funding necessary to achieve these important aims. ..
  45. Geographic Tools for Surveillance and Study of Disease
    Daniel Wartenberg; Fiscal Year: 2003
    ..We will explore methods for imputing values and adjusting for edge effects using methods including Markov Chain Monte Carlo simulations. ..
  46. DIETARY FAT, PLASMA LIPIDS AND OTHER CHD RISK FACTORS.
    Alice Lichtenstein; Fiscal Year: 2003
    ..The investigators state that data derived from the proposed studies could contribute to the database on which to formulate more specific public health recommendations regarding the variables described. ..
  47. Endogenous/Exogenous Sex Hormones & CHD Risk Factors
    Elizabeth Barrett Connor; Fiscal Year: 2003
    ..These observations may aid in deciding whether individual women should use HRT and, if so, which regimen would provide the most benefit with the least risk. ..
  48. ASTHMA CLINICAL RESEARCH NETWORK
    Vernon Chinchilli; Fiscal Year: 2002
    ....
  49. Conference--ISEE 16th Annual Meeting
    Daniel Wartenberg; Fiscal Year: 2004
    ..ISEE provides a variety of forums for discussion, critical reviews, collaborations and education issues for environmental exposures and their human health effects. ..
  50. Animal Models of Schizophrenia: NRG-erbB Function
    Daniela Brunner; Fiscal Year: 2005
    ..Such models will allow testing of antipsychotic treatments based on novel and standard chemistries, and will define the preferred developmental time and drug regime for an optimal therapeutic treatment. ..
  51. Epidemiologic Case-control Study of Barrett's Esophagus
    Nicholas Shaheen; Fiscal Year: 2005
    ..Finally, by comparing subjects with Barrett's to controls with reflux, and controlling for severs of reflux, the impact of a Barrett's diagnosis on quality of life and psychological stress may be seen. ..
  52. Epidemiologic Parameters of Rare Cancer Risk Factors
    Colin Begg; Fiscal Year: 2005
    ..All of these aims are motivated by an international study of the genetic epidemiology of melanoma that is currently in progress. ..
  53. Center for the Study of Violence
    Craig Anderson; Fiscal Year: 2004
    ..abstract not provided ..
  54. EXERCISE, DISABILITY, OSTEOARTHRITIS AND COSTS
    James Fries; Fiscal Year: 2006
    ..They further state that the overall project objective is to understand how improvements in exercise and other risk factor status may retard functional decline and reduce the need for medical care. ..
  55. Quality of Care for Adolescent Suicide Attempters
    Jeffrey Bridge; Fiscal Year: 2008
    ..Together, these projects will inform the design of a future R01 proposal aimed at studying quality of care factors and outcome for at-risk youth across a broader range of service providers and treatment settings. ..
  56. Tailored Interactive Intervention to Increase CRC Screen
    Sally Vernon; Fiscal Year: 2006
    ..Telephone follow-up and medical record review will be conducted 6 months after delivery of the intervention to ascertain completion of CRCS. ..
  57. RESEARCH ETHICS IN SCHIZOPHRENIA
    William Carpenter; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  58. Race and Public Communication about Human Variation
    Celeste Condit; Fiscal Year: 2003
    ..The project will focus on the concerns of African Americans about discrimination and genetics and on attitudes about African Americans and genetics held by European Americans and the general population. ..
  59. TREATMENT OF NEGATIVE SYMPTOMS & COGNITIVE IMPAIRMENTS
    William Carpenter; Fiscal Year: 2003
    ..The study will provide new information on the efficacy of d- cyclosporine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
  60. A Pilot Trial of Oral Melatonin Supplementation in Breast Cancer Survivors
    Eva Schernhammer; Fiscal Year: 2007
    ..This pilot data could lay the groundwork for a large scale trial to assess the chemopreventive potential of melatonin in women, both with and without a personal history of breast cancer. [unreadable] [unreadable] [unreadable]..
  61. National Assessment of the Mortality and Morbidity Effects of Tropospheric Ozone
    Michelle L Bell; Fiscal Year: 2010
    ..The goal of this work is to provide policy-makers, scientists, and the public with a better understanding of how ozone affects health in order to aid more effective decisions regarding protection of human health. ..
  62. Clock Genes, Night Work, and Breast Cancer Risk
    Eva Schernhammer; Fiscal Year: 2008
    ..The results from this study could help identify individuals who are more susceptible to night work than others, based on their genetic profile. ..
  63. Family Involvement /Resident Psychosocial Status in LTC
    JOSEPH GAUGLER; Fiscal Year: 2002
    ..abstract_text> ..
  64. Training for US Cochrane Contributors and Others
    Kay Dickersin; Fiscal Year: 2006
    ..The applicant will collaborate and partner with investigators associated with the EPCs in all stages of the project. [unreadable] [unreadable]..
  65. St. John's Wort for tobacco cessation
    Amit Sood; Fiscal Year: 2006
    ..This study is anticipated to provide the data needed to develop a larger randomized controlled clinical trial submitted through the R01 funding mechanism to NCCAM. [unreadable] [unreadable]..
  66. Management Decisions in Financial Conflicts of Interest
    Lisa Bero; Fiscal Year: 2002
    ..Our findings will allow us to develop a framework for decision-making regarding conflict identification and management. ..
  67. IONDT FOLLOW-UP STUDY
    Kay Dickersin; Fiscal Year: 2002
    ....
  68. Information Technologies to Improve Patient Adherence
    Raymond Ownby; Fiscal Year: 2006
    ..Ownby to develop as a clinical researcher capable of carrying out patient-oriented research studies and give him additional tools in applied cognitive aging and human factors research, especially applications of emerging information. ..
  69. Glycemic Index and Metabolic Syndrome
    ANASTASSIOS PITTAS; Fiscal Year: 2005
    ..abstract_text> ..
  70. Gabapentin for Smoking Abstinence
    Amit Sood; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  71. A Qualitative Study of Editorial Decision-Making
    Lisa Bero; Fiscal Year: 2003
    ..abstract_text> ..
  72. Translating Evidence to Quality Care: Getting the Message to Your Constituency
    Kay Dickersin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  73. Data Coordinating Center for Sleep Heart Health
    Marie Diener West; Fiscal Year: 2007
    ..abstract_text> ..