Genomes and Genes
amino acid repetitive sequences
Summary: A sequential pattern of amino acids occurring more than once in the same protein sequence.
Publications226 found, 100 shown here
- Evolutionary analysis of amino acid repeats across the genomes of 12 Drosophila speciesMelanie A Huntley
Department of Molecular Biology and Genetics Cornell University, USA
Mol Biol Evol 24:2598-609. 2007..With additional evidence to suggest a corresponding elevation in positive selection we propose that some repeats may be inducing compensatory substitutions in their surrounding sequence...
- Insights into DNA recombination from the structure of a RAD51-BRCA2 complexLuca Pellegrini
University of Cambridge, Department of Biochemistry, Tennis Court Road, Cambridge CB2 1GA, UK
Nature 420:287-93. 2002..Cancer-associated mutations that affect the BRC repeat disrupt its predicted interaction with RAD51, yielding structural insight into mechanisms for cancer susceptibility...
- The leucine-rich repeat as a protein recognition motifB Kobe
Department of Biochemistry and Molecular Biology Institute for Molecular Bioscience, University of Queensland, Brisbane, 4072, Queensland, Australia
Curr Opin Struct Biol 11:725-32. 2001....
- Minimal nuclear pore complexes define FG repeat domains essential for transportLisa A Strawn
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 3120A MRBIII, 465 21st Avenue South, Nashville, TN 37232 8240, USA
Nat Cell Biol 6:197-206. 2004..Significantly, symmetric deletions caused mild reductions in Kap95-Kap60-mediated import rates, but virtually abolished Kap104 import. These results suggest the existence of multiple translocation pathways...
- When protein folding is simplified to protein coiling: the continuum of solenoid protein structuresB Kobe
Dept of Biochemistry, University of Queensland, Queensland 4072, Brisbane, Australia
Trends Biochem Sci 25:509-15. 2000..Although solenoid proteins are divided into different classes according to commonly used classification schemes, they share many structural and functional properties...
- TPR proteins: the versatile helixLuca D D'Andrea
Institute of Biostructure and Bioimaging, CNR, Via Mezzocannone 6, 80134, Naples, Italy
Trends Biochem Sci 28:655-62. 2003..Genomic analyses of the distribution of TPR domains are presented along with implications for protein engineering...
- Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domainEric G Huizinga
Department of Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, Netherlands
Science 297:1176-9. 2002..These detailed insights into the initial interactions in platelet adhesion are relevant to the development of antithrombotic drugs...
- Functional insights from the distribution and role of homopeptide repeat-containing proteinsNoel G Faux
Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, School of Computer Science and Software Engineering, Monash University, Clayton Campus, Melbourne, VIC 3800, Australia
Genome Res 15:537-51. 2005..These data reveal that the majority of RCPs are involved in processes that require the assembly of large, multiprotein complexes, such as transcription and signaling...
- Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycanPaul G Scott
Department of Biochemistry and Alberta Synchrotron Institute, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
Proc Natl Acad Sci U S A 101:15633-8. 2004..This motif seems to be unique to SLRPs and has not been observed in any other LRR protein structure to date. Possible implications of these features for decorin ligand binding and SLRP function are discussed...
- Notchless encodes a novel WD40-repeat-containing protein that modulates Notch signaling activityJ Royet
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
EMBO J 17:7351-60. 1998..Biochemical studies show that Notchless binds to the cytoplasmic domain of Notch, suggesting that it serves as a direct regulator of Notch signaling activity...
- The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathyP Bomont
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
Nat Genet 26:370-4. 2000....
- Multiple TPR motifs characterize the Fanconi anemia FANCG proteinEric Blom
Department of Clinical Genetics and Human Genetics, VU University Medical Center, Van der Boechorststraat 7, NL 1081 BT, Amsterdam, The Netherlands
DNA Repair (Amst) 3:77-84. 2004..The recognition of FANCG as a typical TPR protein predicts this protein to play a key role in the assembly and/or stabilization of the nuclear FA protein core complex...
- De novo identification of highly diverged protein repeats by probabilistic consistencyA Biegert
Department for Protein Evolution, Max Planck Institute for Developmental Biology, Spemannstr 35, 72076 Tubingen, Germany
Bioinformatics 24:807-14. 2008....
- The ATRs, ATMs, and TORs are giant HEAT repeat proteinsJason Perry
Cell 112:151-5. 2003
- Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHpY M Chook
Laboratory of Cell Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
Nature 399:230-7. 1999....
- Simple sequences are rare in the Protein Data BankMelanie A Huntley
Department of Biology, McMaster University, Hamilton, Ontario, Canada
Proteins 48:134-40. 2002..This lack of a simple sequence both in the PDB database and in the structural information suggests that this type of simple sequence may produce disordered structures that make structural characterization difficult...
- Oligopeptide repeats in the yeast protein Sup35p stabilize intermolecular prion interactionsS N Parham
Research School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK
EMBO J 20:2111-9. 2001..Modulating repeat number therefore alters the rate of yeast prion conversion in vivo. Furthermore, there appears to be evolutionary conservation of function of the N-terminally located oligopeptide repeats in prion propagation...
- The WD repeat: a common architecture for diverse functionsT F Smith
Boston University, BioMolecular Engineering Research Center, Boston, MA 02215, USA
Trends Biochem Sci 24:181-5. 1999..Proteins that have very similar surfaces are likely to have common binding partners and similar functions...
- mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesIsabelle Behm-Ansmant
European Molecular Biology Laboratory EMBL, Heidelberg, Germany
Genes Dev 20:1885-98. 2006..Our findings indicate that GW182 links the miRNA pathway to mRNA degradation by interacting with AGO1 and promoting decay of at least a subset of miRNA targets...
- Domain combinations in archaeal, eubacterial and eukaryotic proteomesG Apic
Laboratory of Molecular Biology, MRC, Hills Road, Cambridge, CB2 2QH, UK
J Mol Biol 310:311-25. 2001..Finally, we compare the set of the domain combinations in the genomes to those in the RCSB Protein Data Bank, and discuss the implications for structural genomics...
- Diversity in nucleotide binding site-leucine-rich repeat genes in cerealsJianfa Bai
Department of Plant Pathology, Kansas State University, Manhattan, Kansas 66506 5502, USA
Genome Res 12:1871-84. 2002..The resistance gene repertoire of grasses has changed from that of dicots in their independent evolution since the two groups diverged. It is not clear whether this reflects a difference in downstream defense signaling pathways...
- RCPdb: An evolutionary classification and codon usage database for repeat-containing proteinsNoel G Faux
Protein Crystallography Unit, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, Australia
Genome Res 17:1118-27. 2007..Third, homopeptides that are conserved across different species lie within regions that are under stronger purifying selection in contrast to nonconserved homopeptides...
- Peptides trap the human immunodeficiency virus type 1 envelope glycoprotein fusion intermediate at two sitesYong He
Center for Biologics Evaluation and Research, Food and Drug Administration, National Institutes of Health, Bethesda, Maryland 20892, USA
J Virol 77:1666-71. 2003..These results indicate that there are two distinct sites in receptor-activated Env that are potential targets for drug or vaccine development...
- Genome-wide evidence for selection acting on single amino acid repeatsWilfried Haerty
Biology Department, McMaster University, Hamilton, Ontario L8S4L8, Canada
Genome Res 20:755-60. 2010..We also observed lower codon diversity and longer homocodons, suggesting a balance between slippage and point mutations linked to the constraints imposed by selection...
- A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafnessM G Guenther
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine and Genetics, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 USA
Genes Dev 14:1048-57. 2000..Intriguingly, loss-of-function TRbeta mutations cause deafness in mice and humans. These results define a new TR corepressor complex with a physical link to histone structure and a potential biological link to deafness...
- FG-rich repeats of nuclear pore proteins form a three-dimensional meshwork with hydrogel-like propertiesSteffen Frey
Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH, INF 282, D 69120 Heidelberg, Germany
Science 314:815-7. 2006..Furthermore, we obtained evidence that such hydrogel formation is required for viability in yeast...
- Binding site for Robo receptors revealed by dissection of the leucine-rich repeat region of SlitJason A Howitt
Department of Biological Sciences, Imperial College London, London, UK
EMBO J 23:4406-12. 2004..Our results show that a small portion of Slit is able to induce Robo signalling and indicate that the distinct functions of Drosophila Robos are encoded in their divergent cytosolic domains...
- Domain swapping and gene shuffling identify sequences required for induction of an Avr-dependent hypersensitive response by the tomato Cf-4 and Cf-9 proteinsB B Wulff
Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney Lane, Norwich NR4 7UH, United Kingdom
Plant Cell 13:255-72. 2001..Our results demonstrate that sequence variation within the central LRRs of domain C1 and variation in LRR copy number in Cf-4 and Cf-9 play a major role in determining recognition specificity in these proteins...
- Structure of the Nogo receptor ectodomain: a recognition module implicated in myelin inhibitionXiaolin L He
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA
Neuron 38:177-85. 2003..These results now provide a detailed framework for focused structure-function studies aimed at assessing the physiological relevance of NgR-mediated protein-protein interactions to axon regeneration inhibition...
- The InterPro Database, 2003 brings increased coverage and new featuresNicola J Mulder
EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Nucleic Acids Res 31:315-8. 2003..The database is available via a webserver (http://www.ebi.ac.uk/interpro) and anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro)...
- The evolution of amino acid repeat arrays in Plasmodium and other organismsAustin L Hughes
Department of Biological Sciences, University of South Carolina, Coker Life Sciences Building, Columbia, SC 29208, USA
J Mol Evol 59:528-35. 2004....
- Copper(II) inhibits in vitro conversion of prion protein into amyloid fibrilsOlga V Bocharova
Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, USA
Biochemistry 44:6776-87. 2005..Because Cu(2+) may inhibit prion replication, while at the same time stabilize disease-specific isoform against proteolytic clearance, the final outcome of copper-induced effect on progression of prion disease may not be straightforward...
- Serodiagnosis of Leishmania donovani infections: assessment of enzyme-linked immunosorbent assays using recombinant L. donovani gene B protein (GBP) and a peptide sequence of L. donovani GBPA T Jensen
Centre for Medical Parasitology at Institute for Medical Microbiology and Immunology, University of Copenhagen, Denmark
Trans R Soc Trop Med Hyg 93:157-60. 1999..Plasma from healthy Sudanese donors living in an area endemic for malaria but free of leishmaniasis was negative in both assays...
- Structure of importin-beta bound to the IBB domain of importin-alphaG Cingolani
European Molecular Biology Laboratory, Grenoble Outstation, France
Nature 399:221-9. 1999..The structure indicates that significant conformational changes occur when importin-beta binds or releases the IBB domain domain and suggests how dissociation of the importin-alpha/beta heterodimer may be achieved upon nuclear entry...
- Toward the detection and validation of repeats in protein structureKevin B Murray
European Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Proteins 57:365-80. 2004..These reduce the strength of the repeat signal in the SAP matrix, making repeat detection more difficult...
- Somatic diversification of variable lymphocyte receptors in the agnathan sea lampreyZeev Pancer
Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Nature 430:174-80. 2004..Different evolutionary strategies were thus used to generate highly diverse lymphocyte receptors through rearrangement of LRR modules in agnathans (jawless fish) and of immunoglobulin gene segments in gnathostomes (jawed vertebrates)...
- Leucine-rich repeats and pathogen recognition in Toll-like receptorsJessica K Bell
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Building 5, Room 338, National Institutes of Health, Bethesda, MD 20892, USA
Trends Immunol 24:528-33. 2003..Together, these insertions and the beta-sheet could provide a binding surface that is 10-fold greater in area than binding surfaces in antibodies and T-cell receptors...
- ProtRepeatsDB: a database of amino acid repeats in genomesMridul K Kalita
Structural and Computational Biology Group, Malaria Group, International Centre for Genetic Engineering and Biotechnology ICGEB, Aruna Asaf Ali Marg, New Delhi 110067, India
BMC Bioinformatics 7:336. 2006..icgeb.res.in/repeats/ is a relational database of perfect and mismatch repeats, access to which is designed as a resource and collection of tools for detection and cross species comparisons of different types of amino acid repeats...
- Comparison of ARM and HEAT protein repeatsM A Andrade
European Molecular Biology Laboratory, Heidelberg, Germany
J Mol Biol 309:1-18. 2001..Our results illustrate that ARM and HEAT-repeat proteins, while having a common phylogenetic origin, have since diverged significantly. We discuss evolutionary scenarios that could account for the great diversity of repeats observed...
- Constitutive gain-of-function mutants in a nucleotide binding site-leucine rich repeat protein encoded at the Rx locus of potatoAbdelhafid Bendahmane
The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
Plant J 32:195-204. 2002..However activation of Rx is not simply release of negative regulation by the LRR and adjacent sequence because deleted forms of Rx that lack constitutive gain of function mutations are not active unless the protein is overexpressed...
- Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeatE Assier
INSERM U396, Institut Biomedical des Cordeliers, 15 rue de l Ecole de Medecine, 75006, Paris, France
Gene 230:145-54. 1999..Neither construct localised to the nucleolus. The characteristics of RED and its nuclear localisation implicate it as a regulatory protein, possibly involved in transcription...
- Synleurin, a novel leucine-rich repeat protein that increases the intensity of pleiotropic cytokine responsesWei Wang
Human Genome Sciences, Inc, 9410 Key West Avenue, Rockville, MD 20850, USA
Biochem Biophys Res Commun 305:981-8. 2003..Synleurin gene (slrn) maps to human chromosome at 5q12. The name synleurin reflects its synergistic effect on cytokine stimulation and its prominent leucine-rich repeats...
- Mutant WD-repeat protein in triple-A syndromeA Tullio-Pelet
Unité de Recherches sur les Handicaps Génétiques de l Enfant INSERM U 393, Paris, France
Nat Genet 26:332-5. 2000..The expression of the gene in both neuroendocrine and cerebral structures points to a role in the normal development of the peripheral and central nervous systems...
- Comparative analysis of amino acid repeats in rodents and humansM Mar Albà
Grup de Recerca en Informàtica Biomèdica, Departament de Ciencies Experimentals i de la Salut, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, 08003 Barcelona, Spain
Genome Res 14:549-54. 2004..We propose that the different GC content isochore structure in rodents and humans may result in an increased amino acid repeat prevalence in the human lineage...
- Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteinsPrasanna Venkatraman
Department of Cell Biology, 240 Longwood Avenue, Harvard Medical School, Boston, MA 02115, USA
Mol Cell 14:95-104. 2004..Occasional failure of these long undegradable sequences to exit may interfere with proteasome function and help explain why longer polyQ expansions promote early disease onset...
- Cloning of a novel epidermal growth factor repeat containing gene EGFL6: expressed in tumor and fetal tissuesG Yeung
Functional Genomics Department, Immunology Group, Hyseq Inc, Sunnyvale, California 94086, USA
Genomics 62:304-7. 1999..Importantly, its transcripts are expressed in brain and lung tumor and fetal tissues, but are generally absent from normal adult tissues. Implications with respect to cell cycle regulation and oncogenesis are discussed...
- Binding dynamics of isolated nucleoporin repeat regions to importin-betaTimothy A Isgro
Department of Physics, University of Illinois at Urbana Champaign, Beckman Institute for Advanced Science and Technology, Urbana, Illinois 61801, USA
Structure 13:1869-79. 2005....
- Tracking repeats using significance and transitivityRadek Szklarczyk
Centre for Integrative Bioinformatics IBIVU, Faculty of Sciences and Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1081a, Amsterdam, The Netherlands
Bioinformatics 20:i311-7. 2004..Identification of repeats is crucial to shed light on the function and structure of proteins, and explain their evolutionary past. The task is difficult because during the course of evolution many repeats diverged beyond recognition...
- Structural principles of leucine-rich repeat (LRR) proteinsPurevjav Enkhbayar
Division of Biological Resources and Production, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan
Proteins 54:394-403. 2004..The radii of the LRR arc with beta-alpha structural units are smaller than those with beta-3(10) or beta-pII units. The concave face of the LRR beta-sheet forms a surface analogous to a part of a Möbius strip...
- Proteoglycans of the extracellular matrix and growth controlH Kresse
Institute of Physiological Chemistry and Pathobiochemistry, University of Munster, Munster, Germany
J Cell Physiol 189:266-74. 2001....
- Natural selection drives the accumulation of amino acid tandem repeats in human proteinsLoris Mularoni
Biomedical Informatics Research Programme GRIB, Fundació Institut Municipal d Investigació Mèdica, Barcelona 08003, Spain
Genome Res 20:745-54. 2010..The data obtained in this study have allowed us to identify a set of 92 repeats that are postulated to play important functional roles due to their strong selective signature, including five cases with direct experimental evidence...
- Simple sequence repeats in proteins and their significance for network evolutionJohn M Hancock
Bioinformatics Group, MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK
Gene 345:113-8. 2005..We outline a conceptualization of how protein SSRs may arise and become fixed in proteins during evolution, and suggest that emergence and change in length of protein SSRs may affect the topology of protein interaction networks...
- Plant NBS-LRR proteins: adaptable guardsLeah McHale
The Genome Center, University of California, Davis, CA 95616, USA
Genome Biol 7:212. 2006..Their precise role in recognition is unknown; however, they are thought to monitor the status of plant proteins that are targeted by pathogen effectors...
- Molecular features of the copper binding sites in the octarepeat domain of the prion proteinColin S Burns
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
Biochemistry 41:3991-4001. 2002....
- Crystal structure of human toll-like receptor 3 (TLR3) ectodomainJungwoo Choe
Department of Molecular Biology and Skaggs Institute for Chemical Biology, Scripps Research Institute TSRI, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 309:581-5. 2005....
- Detecting cryptically simple protein sequences using the SIMPLE algorithmM Mar Albà
Grup de Recerca en Informàtica Biomèdica, Universitat Pompeu Fabra, Dr Aiguader 80, 08003 Barcelona, Spain
Bioinformatics 18:672-8. 2002..However, many of these regions are encoded by non-repetitive DNA sequences and may therefore result from selection acting on protein structure and/or function...
- Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1Yili Yin
Division of Molecular Physiology, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Science 301:1371-4. 2003..Thus, by minimizing translation of the EBNA1 transcript, cells expressing EBNA1 avoid cytotoxic T cell recognition. At the same time, blocking degradation maintains the EBNA1 expression level...
- Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5G J Gatto
Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Struct Biol 7:1091-5. 2000..This structure reveals the molecular basis for PTS1 recognition and demonstrates a novel mode of TPR-peptide interaction...
- Conserved domains in the chicken homologue of BRCA2Minoru Takata
Department of Immunology and Molecular Genetics, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
Oncogene 21:1130-4. 2002..Thus, chicken BRCA2 may provide a means to identify domains and residues associated with cancer predisposition...
- NLR, the nucleotide-binding domain leucine-rich repeat containing gene familyZhengmao Ye
Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, United States
Curr Opin Immunol 20:3-9. 2008..Its role in inflammation is linked to the formation of biochemical complexes such as the inflammasome, and its roles in cell death might be linked to the proposed formation of pyroptosome and necrosome...
- Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length controlLani C Keller
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
Mol Biol Cell 20:1150-66. 2009..Together, these data suggest that POC1 is involved in early steps of centriole duplication as well as in the later steps of centriole length control...
- Tandem and cryptic amino acid repeats accumulate in disordered regions of proteinsMichelle Simon
Bioinformatics Group, MRC Harwell, Mammalian Genetics Unit, Harwell Science and Innovation Campus, Harwell, Oxfordshire OX110RD, UK
Genome Biol 10:R59. 2009..We consider two classes of AAR (tandem repeats and cryptic repeats: regions of proteins containing overrepresentations of short amino acid repeats)...
- Review: proteins with repeated sequence--structural prediction and modelingA V Kajava
Center for Molecular Modeling, Bethesda, Maryland 20892-5626, USA
J Struct Biol 134:132-44. 2001..The models of leucine-rich repeat proteins and bacterial proteins with pentapeptide repeats are examined in light of the recently solved structures of the related molecules...
- Analyses of six homologous proteins of Protochlamydia amoebophila UWE25 encoded by large GC-rich genes (lgr): a model of evolution and concatenation of leucine-rich repeatsMyriam Eugster
Center for Research on Intracellular Bacteria CRIB, Institute of Microbiology, University Hospital Center and University of Lausanne, Switzerland
BMC Evol Biol 7:231. 2007..6-kb gene similar to five others of P. amoebophila: lgrA to lgrD, lgrF. We describe here the structure, regulation and evolution of these proteins termed LGRs since encoded by "Large G+C-Rich" genes...
- Molecular cloning and characterization of a novel repeat-containing Leishmania major gene, ppg1, that encodes a membrane-associated form of proteophosphoglycan with a putative glycosylphosphatidylinositol anchorT Ilg
Max Planck Institut fur Biologie, Abteilung Membranbiochemie, Corrensstrasse 38, D 72076 Tubingen, Germany
J Biol Chem 274:31410-20. 1999..Therefore this membrane-bound proteophosphoglycan may be important for direct host-parasite interactions...
- A mutation within the leucine-rich repeat domain of the Arabidopsis disease resistance gene RPS5 partially suppresses multiple bacterial and downy mildew resistance genesR F Warren
Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
Plant Cell 10:1439-52. 1998..The third LRR is relatively well conserved, and we speculate that it may interact with a signal transduction component shared by multiple R gene pathways...
- Recent improvements to the SMART domain-based sequence annotation resourceIvica Letunic
EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany
Nucleic Acids Res 30:242-4. 2002..SMART output can now be easily included in users' documents. A SMART mirror has been created at http://smart.ox.ac.uk...
- Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signallingE Dumont
, , , Germany
Oncogene 19:556-61. 2000..Therefore, the ankyrin repeat domain of Notch-IC might trigger novel pathways relevant for transformation but unrelated to RBP-J signalling...
- A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicingP Ajuh
School of Life Sciences, The University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
J Biol Chem 276:42370-81. 2001..Thus, a direct interaction between the CDC5L protein and PLRG1 in the CDC5L complex is essential for pre-mRNA splicing progression...
- Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD fingerHaitao Li
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Mol Cell 28:677-91. 2007....
- Inherited prion disease with 5-OPRI: phenotype modification by repeat length and codon 129S Mead
MRC Prion Unit and Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London, UK
Neurology 69:730-8. 2007..An individual inherited prion disease offers an opportunity to study the determinants of this clinicopathologic heterogeneity among individuals with the same causal mutation...
- A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchangeMahmud K K Shivji
Cancer Research UK Department of Oncology and The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK
Nucleic Acids Res 34:4000-11. 2006..Thus, the human BRC repeats, embedded within their surronding sequences as an eight-repeat unit, mediate homologous recombination independent of the BRCA2(CTD) through a previously unrecognized role in control of RAD51 activity...
- The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysineClara M Santiveri
MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK
J Mol Biol 382:1107-12. 2008..The crystal structure of the complex between the protein and monomethyllysine reveals that the modified amino acid binds to an aromatic rich pocket at one end of the beta-barrel of the second repeat...
- PPR motifs of the nucleus-encoded factor, PGR3, function in the selective and distinct steps of chloroplast gene expression in ArabidopsisHiroyuki Yamazaki
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara 630 0101, Japan
Plant J 38:152-63. 2004..We consider that the different domains of the PPR repeats in PGR3 might have different functions in conferring RNA stability and probably allowing translation as well as recognizing at least two distinct target RNAs...
- Disulfide structure of the leucine-rich repeat C-terminal cap and C-terminal stalk region of Nogo-66 receptorDingyi Wen
BiogenIdec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
Biochemistry 44:16491-501. 2005..A structural model of the LRRCT with extended residues 311-344 from the CT stalk region is proposed, and its function in coreceptor binding is discussed...
- CD8 T cell recognition of endogenously expressed epstein-barr virus nuclear antigen 1Steven P Lee
Institute for Cancer Studies, University of Birmingham, Vincent Drive, Edgbaston, Birmingham B15 2TT, UK
J Exp Med 199:1409-20. 2004..We infer that EBNA1-specific CD8+ T cells do play a role in control of EBV infection in vivo and might be exploitable in the control of EBV+ malignancies...
- Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomesHui Huang
Department of Bioinformatics, Genome Therapeutics Corporation, Waltham, MA 02453, USA
Genome Biol 5:R47. 2004..Here, we investigate whether human disease genes differ significantly from their rodent orthologs with respect to their overall levels of conservation and their rates of evolutionary change...
- Copper binding in the prion proteinGlenn L Millhauser
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
Acc Chem Res 37:79-85. 2004..The link between prion protein and copper may provide insight into the general, and recently appreciated, role of metals in neurodegenerative disease...
- HEAT repeats associated with condensins, cohesins, and other complexes involved in chromosome-related functionsA F Neuwald
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724
Genome Res 10:1445-52. 2000..Hence, our analysis predicts structural features of these proteins and suggests that HEAT repeats may play important roles in chromosome dynamics...
- Mutations in NYX, encoding the leucine-rich proteoglycan nyctalopin, cause X-linked complete congenital stationary night blindnessN T Bech-Hansen
Department of Medical Genetics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
Nat Genet 26:319-23. 2000..The role of other SLRP proteins suggests that mutant nyctalopin disrupts developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB...
- Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1Bart Janssen
Institute of Human Genetics Heidelberg, Heidelberg, Germany
Diabetes 54:2320-7. 2005..Diabetic patients with the CNDP1 Mannheim variant are less susceptible for nephropathy. Carnosine protects against the adverse effects of high glucose levels on renal cells...
- Expression and properties of wild-type and mutant forms of the Drosophila sex comb on midleg (SCM) repressor proteinD Bornemann
Department of Biochemistry and Department of Genetics and Cell Biology, University of Minnesota, St Paul, Minnesota 55108, USA
Genetics 150:675-86. 1998..pupal development. We suggest that the mbt repeat alleles produce altered SCM proteins that incorporate into and impair function of PcG protein complexes...
- The octarepeat domain of the prion protein binds Cu(II) with three distinct coordination modes at pH 7.4Madhuri Chattopadhyay
Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
J Am Chem Soc 127:12647-56. 2005..This work provides the first complete characterization of all dominant copper coordination modes at pH 7.4...
- Extensive antigenic polymorphism within the repeat sequence of the Plasmodium falciparum merozoite surface protein 1 block 2 is incorporated in a minimal polyvalent immunogenKevin K A Tetteh
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, London WC1E 7HT, United Kingdom
Infect Immun 73:5928-35. 2005..Thus, complex allelic polymorphism was deconstructed and a minimal composite polyvalent antigen was engineered, delivering a designed candidate sequence for inclusion in a malaria vaccine...
- Disorder and sequence repeats in hub proteins and their implications for network evolutionZsuzsanna Dosztanyi
Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, 1518 Budapest, Hungary
J Proteome Res 5:2985-95. 2006....
- Structural analysis of leucine-rich-repeat variants in proteins associated with human diseasesN Matsushima
Division of Biophysics, School of Health Sciences, Sapporo Medical University, Sapporo, Hokkaido, 060 8556, Japan
Cell Mol Life Sci 62:2771-91. 2005..In contrast, missense mutations at some specific positions in LRRs are very rare or are not observed at all...
- Transgenic mice expressing bovine PrP with a four extra repeat octapeptide insert mutation show a spontaneous, non-transmissible, neurodegenerative disease and an expedited course of BSE infectionJ Castilla
Centro de Investigacion en Sanidad Animal, INIA, 28130 Valdeolmos, Madrid, Spain
FEBS Lett 579:6237-46. 2005..This Tg mouse model constitutes a new way of understanding the pathobiology of bovine transmissible spongiform encephalopathy. Its potential applications include the assessment of new therapies against prion diseases...
- Rapid automatic detection and alignment of repeats in protein sequencesA Heger
European Bioinformatics Institute, Cambridge, United Kingdom
Proteins 41:224-37. 2000..This illustrates how in times when curated databases grapple with ever increasing backlogs, automatic (re)analysis of sequences provides an efficient way to capture this important information...
- Inhibition of antigen presentation by the glycine/alanine repeat domain is not conserved in simian homologues of Epstein-Barr virus nuclear antigen 1N W Blake
CRC Institute for Cancer Studies, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TA, United Kingdom
J Virol 73:7381-9. 1999....
- Analyses of non-leucine-rich repeat (non-LRR) regions intervening between LRRs in proteinsNorio Matsushima
Sapporo Medical University Center for Medical Education, Sapporo, Hokkaido 060 8556, Japan
Biochim Biophys Acta 1790:1217-37. 2009..Many proteins have LRR (leucine-rich repeat) units interrupted by non-LRRs which we call IR (non-LRR island region)...
- Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout miceE Flechsig
Institut fur Molekularbiologie, Abteilung I, Universitat Zurich, Switzerland
Neuron 27:399-408. 2000..Thus, while the region comprising the octarepeats is not essential for mediating pathogenesis and prion replication, it modulates the extent of these events and of disease presentation...
- The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchangeMahmud K K Shivji
The Medical Research Council Cancer Cell Unit, Hutchison MRC Research Centre, Hills Road, Cambridge CB2 0XZ, United Kingdom
Proc Natl Acad Sci U S A 106:13254-9. 2009..Our work provides fresh insight into the mechanism of HDR in humans, and its regulation by the BRCA2 tumor suppressor...
- Genome-wide analysis of NBS-LRR-encoding genes in ArabidopsisBlake C Meyers
Department of Vegetable Crops, University of California, Davis, California 95616, USA
Plant Cell 15:809-34. 2003..The observed diversity of these NBS-LRR proteins indicates the variety of recognition molecules available in an individual genotype to detect diverse biotic challenges...
- A novel potential surface protein in Trichomonas vaginalis contains a leucine-rich repeat shared by micro-organisms from all three domains of lifeRobert P Hirt
Department of Zoology, The Natural History Museum, Cromwell Road, London SW7 5BD, UK
Mol Biochem Parasitol 125:195-9. 2002
- Protein repeats: structures, functions, and evolutionM A Andrade
European Molecular Biology Laboratory, Meyerhofstr. 1, Heidelberg, 69012, Germany
J Struct Biol 134:117-31. 2001....
- Molecular characterization of h-l(3)mbt-like: a new member of the human mbt familyJ Wismar
FEBS Lett 507:119-21. 2001
- Epidermal growth factor (EGF)-like repeats of human tenascin-C as ligands for EGF receptorC S Swindle
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Cell Biol 154:459-68. 2001..These data identify a new class of "insoluble" growth factor ligands and a novel mode of activation for growth factor receptors...
- Patterns of positive selection in the complete NBS-LRR gene family of Arabidopsis thalianaMariana Mondragon-Palomino
Department of Ecology and Evolutionary Biology, University of California Irvine, Irvine, California 92612, USA
Genome Res 12:1305-15. 2002..LRRs also contain substantial indel variation, suggesting elasticity in LRR length could also influence resistance specificity...
- Proteomic analysis of nucleoporin interacting proteinsN P Allen
Department of Biological Sciences, Stanford University, Stanford, California 94305-5020, USA
J Biol Chem 276:29268-74. 2001..The results demonstrate a global role for Gsp1p-GTP on karyopherin-nucleoporin interactions and provide a rudimentary map of the routes that karyopherins take as they cross the nuclear pore complex...
- Involvement of leucine residues at positions 107, 112, and 115 in a leucine-rich repeat motif of human Toll-like receptor 2 in the recognition of diacylated lipoproteins and lipopeptides and Staphylococcus aureus peptidoglycansMari Fujita
Department of Oral Pathobiological Science, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan
J Immunol 171:3675-83. 2003..aureus peptidoglycans...
- Solution NMR study of the interaction between NTF2 and nucleoporin FxFG repeatsJonathan Morrison
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
J Mol Biol 333:587-603. 2003....
- Molecular Mechanisms of Regulation of ContractionSarah Hitchcock DeGregori; Fiscal Year: 2005..The results will help understand how the cytoskeleton is remodeled during complex functions such as leucocyte chemotaxis and growth factor-stimulated cellular outgrowth, processes important in both normal and pathological states. ..
- REGULATION OF CONTRACTION IN MUSCLE AND NONMUSCLE CELLSSarah Hitchcock DeGregori; Fiscal Year: 2006..unreadable] [unreadable]..
- Imprinted SnoRNA Genes in the PWS deletion RegionUta Francke; Fiscal Year: 2005..abstract_text> ..
- Pathophysiology of Rett Syndrome /MECP2 MutationsHuda Zoghbi; Fiscal Year: 2005..abstract_text> ..
- 2005 CAG Triplet Repeat Disorders Gordon ConferenceMichael Levine; Fiscal Year: 2005..All participants will be required to present posters. Priority will be given to women, minorities, and persons with disabilities when selecting participants. ..
- EVOLUTION OF IMMUNE RECOGNITION AND EVASIONAustin L Hughes; Fiscal Year: 2010..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
- High-Throughput Screening for Human Immunodeficiency Virus Fusion InhibitorsMiriam Gochin; Fiscal Year: 2008..Newly discovered small molecule candidates may be developed into entry inhibitors effective in controlling HIV-1 infection, as part of a multi-drug treatment strategy. [unreadable] [unreadable] [unreadable]..
- INHIBITION OF THE ANGIOGENIC RESPONSELuisa Iruela Arispe; Fiscal Year: 2006..abstract_text> ..
- Transgenic Models of Huntington's DiseaseChristopher Ross; Fiscal Year: 2006..The new mouse model will be useful for studying pathogenic features of HD, and for testing experimental therapeutic interventions. ..
- Neurophysiological Modulation by Dopamine in the NeostriatumMichael Levine; Fiscal Year: 2008..unreadable] [unreadable]..
- MECHANISMS OF MICROTUBULE AND MITOTIC SPINDLE ASSEMBLYLynne Cassimeris; Fiscal Year: 2006..To address these issues, we will apply a number of fluorescence-based imaging methods combined with siRNA or injection of function-blocking proteins or antibodies. ..
- Regulation of HIV-1 RNA ProcessingMassimo Caputi; Fiscal Year: 2007..Possible coupling of HIV-1 transcription and splicing will be investigated, using both a coupled transcription-splicing assay and transient transfection experiments. ..
- Tissue Transglutaminase in Neurologic InjuryTHUNG SHEN LAI; Fiscal Year: 2007..The inhibitors will be used to investigate the role of TTG in the pathogenesis of expanded polyQ diseases. Current proposal will lead to new therapy for HD and other neurologic disorders. [unreadable] [unreadable] [unreadable]..
- Neurodegeneration and Polyglutamine Toxicity DRPLAChristopher Ross; Fiscal Year: 2007..Proteolytic cleavage would be an especially good target for therapeutic interventions. [unreadable] [unreadable]..
- Regulation of Vascular Function by Progesterone ReceptorLuisa Iruela Arispe; Fiscal Year: 2007..abstract_text> ..
- Antigenic variation in rickettsial transmissionGuy Palmer; Fiscal Year: 2008..This hypothesis will be addressed using comprehensive identification of the variant population in the reservoir host and tick vector and testing whether immune responses against a broad array of variants prevents superinfection. ..
- SUPPRESSION OF VASCULAR GROWTHLuisa Iruela Arispe; Fiscal Year: 2008..We anticipate that results from these experiments will shed light into the biology of tumor growth and angiogenesis. ..
- Evaluating Drug Toxicity in Humanized YeastCharles Miller; Fiscal Year: 2007..abstract_text> ..
- RECEPTOR GENE TRANSCRIPTION IN HUNTINGTON'S DISEASEJang Ho Cha; Fiscal Year: 2008..Such fundamental mechanistic information is critical to the eventual development of effective therapy for HD. ..
- Therapeutic Vaccine for EBV-associated Hodgkins DiseaseRajiv Khanna; Fiscal Year: 2005..The long-term aim of this project is to develop a rational basis for the delivery of a curative EBV-specific CTL immunity to not only in HIV patients with HD patients but also for non-HIV HD. ..
- AUTOMATED PROTEIN FOLD MODEL GENERATIONTemple Smith; Fiscal Year: 2003..In addition, these libraries and their associated analysis tools will provide valuable data to aid in the experimental design to test predictions about the cellular roles of such proteins. ..
- 2003 Gordon Conference on CAG Triplet Repeat DisordersMichael Levine; Fiscal Year: 2003..All participants (except speakers and discussants) will be required to present posters. Priority will be given to women, minorities, and persons with disabilities when selecting participants. ..
- AUTOANTIGEN RNA HELICASE II/GUBenigno Valdez; Fiscal Year: 2003..This study may also provide an impetus for understanding the pathological roles of RH-II/Gu on the elicitation of autoimmune responses. ..
- PREQUEL Study In PRE-manifest HD of CoQ10/UbiquinonE Leading to Preventive TrialsChristopher A Ross; Fiscal Year: 2010....
- Gene Gun Technology, Opioids, and Corneal DiseasesIAN ZAGON; Fiscal Year: 2003..Ultimately, such data can be employed to design molecular strategies to remedy visual dysfunction. ..
- Elucidating the Roles of SHANK3 and FXR in the Autism InteractomeHuda Y Zoghbi; Fiscal Year: 2010..In this grant, we will characterize some common pathways leading to autism, which would be of public health relevance because our studies will help many types of autism rather than one or two subtypes. ..
- MOLECULAR MECHANISMS LEADING TO RETT SYNDROMEUta Francke; Fiscal Year: 2002..Newborn screening programs could identify presymptomatic mutation carriers. One the causative genetic mechanism is known, understanding of the pathophysiology may lead to early therapeutic intervention. ..
- Conference on Genotype to Phenotype: Focus on DiseaseUta Francke; Fiscal Year: 2002..techniques, resources and approaches as they arise in different disciplines. In scope and orientation, this conference is unlike any others that have been organized recently. It is timely and its impact will likely be high. ..
- Angiogenesis and Microcirculation Gordon ConferenceLuisa Iruela Arispe; Fiscal Year: 2005..The conference will be held in Salve Regina University from August 10-15, 2003. ..
- MOLECULAR GENETIC ANALYSIS OF S. MUTANS CARIOGENICITYAshu Sharma; Fiscal Year: 2004..The specific aims of this proposal are designed to provide new information regarding essential virulence factors of S. mutans which could be exploited to design novel anticaries strategies. ..
- NMDA RECEPTOR DEVELOPMENT IN NEOSTRIATUMMichael Levine; Fiscal Year: 2001..The outcomes will provide information necessary to understand the role of these receptors in NS development and provide clues for generating rational strategies to treat GluR dysfunction during development and in the adult. ..
- Oral spirochetes: molecular genetic analysisAshu Sharma; Fiscal Year: 2004..pallidum, may play a role in periodontitis will be examined. These approaches should increase understanding of the molecular basis for the pathogenicity of spirochetes. ..
- Gene Duplication and Genome EvolutionAustin Hughes; Fiscal Year: 2004..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
- ARYL HYDROCARBON RECEPTOR STRUCTURE AND INTERACTIONSCharles Miller; Fiscal Year: 2002..Characterization of these mutated derivatives will further elucidate the structural features of HSP90 and AHR. These studies will provide significant new information about the molecular biology of AHR-mediated signal transduction. ..
- THERAPEUTIC ANTIANGIOGENESISLuisa Iruela Arispe; Fiscal Year: 2002..abstract_text> ..
- Function of Genes in Williams Syndrome Deletion RegionUta Francke; Fiscal Year: 2005....
- Development of Preventative and Therapeutic HCV VaccinesDavid Milich; Fiscal Year: 2006..It is anticipated that a NS3/4A DNA vaccine may be used for prophylactic or therapeutic applications either alone or in combination with E2-WHcAg hybrid particles. ..
- DEVELOPMENT OF THE HBCAG AS A VACCINE CARRIER PLATFORMDavid Milich; Fiscal Year: 2008..abstract_text> ..
- Protection of Centromeric Cohesion by Bub1 and Sgo1Hongtao Yu; Fiscal Year: 2010....
- The Maternal/Fetal InteractionEdward Schmidt; Fiscal Year: 2009..These results could lead to novel prognostic tools for predicting susceptibility to spontaneous miscarriages. ..
- Regulation of the Anaphase-Promoting Complex by the Spindle CheckpointHongtao Yu; Fiscal Year: 2010..Experiments in this proposal will shed light on the molecular basis of the spindle checkpoint, which might eventually lead to new strategies to treat human cancers. ..
- Neurochemical Correlates of Pathology in Spinocerebellar AtaxiasGULIN OZ; Fiscal Year: 2008..Successful application of such treatments is expected to reduce the burden caused by these diseases on individuals, their families and society. [unreadable] [unreadable] [unreadable]..
- REGULATORY MECHANISMS OF KALIRIN'S GEF1 DOMAINMartin Schiller; Fiscal Year: 2006..Understanding the mechanism by which the GEF domain of kalirin is controlled will provide a basis for future studies to determine the mechanisms by which kalirin controls neuronal morphology. ..
- Epigenetics of Dietary and Body Fat in DrosophilaDouglas Ruden; Fiscal Year: 2006..abstract_text> ..
- The role of nuclear lamins in muscle diseaseBrian Burke; Fiscal Year: 2006..abstract_text> ..
- GLUTAMATE BIOSYNTHESIS MUTANTS AND ALCOHOL SENSITIVITYDouglas Ruden; Fiscal Year: 2003..This genetic approach would eventually lead to a better understanding to a better understanding of the genetic influences that underlie risk for alcoholism. ..
- Toxicogenomics of Lead, Mercury, and CadmiumDouglas Ruden; Fiscal Year: 2003....
- CR1 AND FCYRIIA/IIIA DEFECTS IN THE PATHOGENESIS OF SLEDANIEL BIRMINGHAM; Fiscal Year: 2001..The results of the proposed studies should clarify the roles that both genetic and acquired defects in CR1 play in the onset and disease manifestation of SLE. ..
- Generation of babesial surface protein diversitySHAWN BERENS; Fiscal Year: 2006..The sponsors collaborate closely in research and have successfully mentored clinicians, graduate students, and post-doctoral fellows to research independence. ..
- Dominant Mutation that Affect EGF-R Signal TransductionDouglas Ruden; Fiscal Year: 2003..It is important to understand regulators of RTK signaling because Ras-Raf dependent neoplasia accounts for as many as one-fifth of all human cancers. ..