factual databases

Summary

Summary: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.

Top Publications

  1. pmc Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
    S F Altschul
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 25:3389-402. 1997
  2. pmc The Protein Data Bank
    H M Berman
    Research Collaboratory for Structural Bioinformatics RCSB, Rutgers University, Piscataway, NJ 08854 8087, USA
    Nucleic Acids Res 28:235-42. 2000
  3. pmc The KEGG resource for deciphering the genome
    Minoru Kanehisa
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 32:D277-80. 2004
  4. ncbi The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
    Justin Lamb
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Science 313:1929-35. 2006
  5. ncbi The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models
    M Hucka
    Control and Dynamical Systems, MC 107 81, California Institute of Technology, Pasadena, CA 91125, USA
    Bioinformatics 19:524-31. 2003
  6. pmc dbSNP: the NCBI database of genetic variation
    S T Sherry
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA
    Nucleic Acids Res 29:308-11. 2001
  7. ncbi The sequence of the human genome
    J C Venter
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 291:1304-51. 2001
  8. pmc DrugBank: a knowledgebase for drugs, drug actions and drug targets
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 36:D901-6. 2008
  9. ncbi Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search
    Andrew Keller
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Anal Chem 74:5383-92. 2002
  10. pmc Benchmarking sets for molecular docking
    Niu Huang
    Department of Pharmaceutical Chemistry, University of California San Francisco, QB3 Building, 1700 4th Street, Box 2550, San Francisco, California 94143 2550, USA
    J Med Chem 49:6789-801. 2006

Research Grants

  1. EXAMINING NURSING HOME COMPARE
    Nicholas Castle; Fiscal Year: 2005
  2. Are Volume Standards Accurate Measures of Quality?
    Laurent Glance; Fiscal Year: 2005
  3. INCIDENT REPORTING IN NURSING HOMES
    Nicholas Castle; Fiscal Year: 2008
  4. Staffing Characteristics of Nursing Homes and Quality
    Nicholas Castle; Fiscal Year: 2008
  5. Interoperation of Genome Databases and Tools
    Kei Hoi Cheung; Fiscal Year: 2005
  6. EVALUATION OF OSTEOARTHRITIS-RELATED WORK DISABILITY
    Saralynn Allaire; Fiscal Year: 2004
  7. Lymphoma in Autoimmune Disease: Consequence of Immune Suppression or Stimulation?
    Sasha Bernatsky; Fiscal Year: 2008
  8. The Influence of Staff Turnover on Quality
    Nicholas Castle; Fiscal Year: 2007
  9. Data Consistency Based Motion Artifact Reduction for Head CT
    Hengyong Yu; Fiscal Year: 2008
  10. Ergonomic Interventions for Garment Work
    Beate Ritz; Fiscal Year: 2004

Detail Information

Publications316 found, 100 shown here

  1. pmc Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
    S F Altschul
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 25:3389-402. 1997
    ..PSI-BLAST is used to uncover several new and interesting members of the BRCT superfamily...
  2. pmc The Protein Data Bank
    H M Berman
    Research Collaboratory for Structural Bioinformatics RCSB, Rutgers University, Piscataway, NJ 08854 8087, USA
    Nucleic Acids Res 28:235-42. 2000
    ..This paper describes the goals of the PDB, the systems in place for data deposition and access, how to obtain further information, and near-term plans for the future development of the resource...
  3. pmc The KEGG resource for deciphering the genome
    Minoru Kanehisa
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 32:D277-80. 2004
    ..New efforts are being made to abstract knowledge, both computationally and manually, about ortholog clusters in the KO (KEGG Orthology) database, and to collect and analyze carbohydrate structures in the GLYCAN database...
  4. ncbi The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
    Justin Lamb
    Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA
    Science 313:1929-35. 2006
    ..These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project...
  5. ncbi The systems biology markup language (SBML): a medium for representation and exchange of biochemical network models
    M Hucka
    Control and Dynamical Systems, MC 107 81, California Institute of Technology, Pasadena, CA 91125, USA
    Bioinformatics 19:524-31. 2003
    ..Molecular biotechnology now makes it possible to build elaborate systems models, but the systems biology community needs information standards if models are to be shared, evaluated and developed cooperatively...
  6. pmc dbSNP: the NCBI database of genetic variation
    S T Sherry
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA
    Nucleic Acids Res 29:308-11. 2001
    ..The complete contents of dbSNP are available to the public at website: http://www.ncbi.nlm.nih.gov/SNP. The complete contents of dbSNP can also be downloaded in multiple formats via anonymous FTP at ftp://ncbi.nlm.nih.gov/snp/...
  7. ncbi The sequence of the human genome
    J C Venter
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 291:1304-51. 2001
    ..Less than 1% of all SNPs resulted in variation in proteins, but the task of determining which SNPs have functional consequences remains an open challenge...
  8. pmc DrugBank: a knowledgebase for drugs, drug actions and drug targets
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 36:D901-6. 2008
    ..DrugBank has also significantly improved the power and simplicity of its structure query and text query searches. DrugBank is available at http://www.drugbank.ca...
  9. ncbi Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search
    Andrew Keller
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Anal Chem 74:5383-92. 2002
    ..This analysis makes it possible to filter large volumes of MS/MS database search results with predictable false identification error rates and can serve as a common standard by which the results of different research groups are compared...
  10. pmc Benchmarking sets for molecular docking
    Niu Huang
    Department of Pharmaceutical Chemistry, University of California San Francisco, QB3 Building, 1700 4th Street, Box 2550, San Francisco, California 94143 2550, USA
    J Med Chem 49:6789-801. 2006
    ..DUD is freely available online as a benchmarking set for docking at http://blaster.docking.org/dud/...
  11. pmc ZINC--a free database of commercially available compounds for virtual screening
    John J Irwin
    Department of Pharmaceutical Chemistry, University of California San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94143, USA
    J Chem Inf Model 45:177-82. 2005
    ..Users can process their own molecules by uploading them to a server. Our hope is that this database will bring virtual screening libraries to a wide community of structural biologists and medicinal chemists...
  12. pmc The Unified Medical Language System (UMLS): integrating biomedical terminology
    Olivier Bodenreider
    Lister Hill Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Nucleic Acids Res 32:D267-70. 2004
    ..All vocabularies are available at no fee for research purposes within an institution, but UMLS users are required to sign a license agreement. The UMLS knowledge sources are distributed on CD-ROM and by FTP...
  13. pmc Reactome: a knowledgebase of biological pathways
    G Joshi-Tope
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    Nucleic Acids Res 33:D428-32. 2005
    ..The database is publicly available under open source terms, which allows both its content and its software infrastructure to be freely used and redistributed...
  14. ncbi SYFPEITHI: database for MHC ligands and peptide motifs
    H Rammensee
    Universitat Tubingen, Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    Immunogenetics 50:213-9. 1999
    ..Hyperlinks to the EMBL and PubMed databases are included. In addition, ligand predictions are available for a number of MHC allelic products. The database content is restricted to published data only...
  15. pmc PubChem: a public information system for analyzing bioactivities of small molecules
    Yanli Wang
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 37:W623-33. 2009
    ..Most of the tools described in this work can be directly accessed at http://pubchem.ncbi.nlm.nih.gov/assay/. URLs for accessing other tools described in this work are specified individually...
  16. ncbi The properties of known drugs. 1. Molecular frameworks
    G W Bemis
    Vertex Pharmaceuticals, Cambridge, Massachusetts 02139 4242, USA
    J Med Chem 39:2887-93. 1996
    ..We discuss the possible interpretations of these findings and the way they may be used to guide future drug discovery research...
  17. pmc HMDB: the Human Metabolome Database
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 35:D521-6. 2007
    ..The HMDB is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. The HMDB is available at: www.hmdb.ca...
  18. pmc From genomics to chemical genomics: new developments in KEGG
    Minoru Kanehisa
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Nucleic Acids Res 34:D354-7. 2006
    ..Additionally, drug information is now stored separately and linked to new KEGG DRUG structure maps...
  19. pmc PDBsum: summaries and analyses of PDB structures
    R A Laskowski
    Department of Crystallography, Birkbeck College, University of London, Malet Street, London WC1E 7HX, UK
    Nucleic Acids Res 29:221-2. 2001
    ..Numerous links take the user to related sites. PDBsum is updated whenever any new structures are released by the PDB and is freely accessible via http://www.biochem.ucl.ac.uk/bsm/pdbsum...
  20. pmc The ENZYME database in 2000
    A Bairoch
    Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    Nucleic Acids Res 28:304-5. 2000
    ..In recent years it has became an indispensable resource for the development of metabolic databases. The current version contains information on 3705 enzymes. It is available through the ExPASy WWW server (http://www.expasy.ch/enzyme/ )...
  21. ncbi Drug-target network
    Muhammed A Yildirim
    Center for Cancer Systems Biology CCSB, Harvard Medical School, 44 Binney St, Boston, Massachusetts 02115, USA
    Nat Biotechnol 25:1119-26. 2007
    ..Significant differences in distance were found between etiological and palliative drugs. A recent trend toward more rational drug design was observed...
  22. pmc LIPID MAPS online tools for lipid research
    Eoin Fahy
    LIPID MAPS Bioinformatics Core, San Diego Supercomputer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA
    Nucleic Acids Res 35:W606-12. 2007
    ..The MS prediction tools are available for three categories of lipids: (i) mono/di/triacylglycerols, (ii) glycerophospholipids and (iii) cardiolipins. The LIPID MAPS online tools are publicly available at www.lipidmaps.org/tools/...
  23. ncbi The CellML Model Repository
    Catherine M Lloyd
    Auckland Bioengineering Institute, The University of Auckland, Auckland 1010, New Zealand
    Bioinformatics 24:2122-3. 2008
    ..As the CellML community grows, and more people add their models to the repository, model annotation will become increasingly important to facilitate data searches and information retrieval...
  24. ncbi Reoptimization of MDL keys for use in drug discovery
    Joseph L Durant
    MDL Information Systems, 14600 Catalina Street, San Leandro, California 94577, USA
    J Chem Inf Comput Sci 42:1273-80. 2002
    ..Instead multiple, equally optimal keysets could be produced which had relatively low overlap of the descriptors they encoded...
  25. pmc DrugBank: a comprehensive resource for in silico drug discovery and exploration
    David S Wishart
    Department of Computing Science, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 34:D668-72. 2006
    ..DrugBank is available at http://redpoll.pharmacy.ualberta.ca/drugbank/...
  26. pmc KEGG for linking genomes to life and the environment
    Minoru Kanehisa
    Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan
    Nucleic Acids Res 36:D480-4. 2008
    ..KEGG DRUG contains all approved drugs in the US and Japan, and KEGG DISEASE is a new database linking disease genes, pathways, drugs and diagnostic markers...
  27. ncbi Similarity-based virtual screening using 2D fingerprints
    Peter Willett
    Krebs Institute for Biomolecular Research and Department of Information Studies, University of Sheffield, 211 Portobello, Sheffield S1 4DP, UK
    Drug Discov Today 11:1046-53. 2006
    ..We demonstrate the effectiveness of this approach to screening, and also describe an approximate form of group fusion, turbo similarity searching, that can be used when just a single reference structure is available...
  28. pmc ModelDB: A Database to Support Computational Neuroscience
    Michael L Hines
    Department of Computer Science, Yale University, New Haven CT, USA
    J Comput Neurosci 17:7-11. 2004
    ..ModelDB is a web-accessible database for convenient entry, retrieval, and running of published models on different platforms. This article provides a guide to entering a new model into ModelDB...
  29. pmc HMDB: a knowledgebase for the human metabolome
    David S Wishart
    Department of Computing Science, Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada T6G 2E8
    Nucleic Acids Res 37:D603-10. 2009
    ..Changes to the user-interface have also been implemented to accommodate future expansion and to make database navigation much easier. These improvements should make the HMDB much more useful to a much wider community of users...
  30. ncbi Online retrieval, processing, and visualization of primate connectivity data from the CoCoMac database
    Rolf Kötter
    C and O Vogt Brain Research Institute, Heinrich Heine University Dusseldorf, Moorenstr 5, D 40225, Germany
    Neuroinformatics 2:127-44. 2004
    ....
  31. ncbi A reference ontology for biomedical informatics: the Foundational Model of Anatomy
    Cornelius Rosse
    Departments of Biological Structure, and Medical Education and Biomedical Informatics, Structural Informatics Group, University of Washington, Seattle, WA 98195, USA
    J Biomed Inform 36:478-500. 2003
    ....
  32. pmc Metabolomic database annotations via query of elemental compositions: mass accuracy is insufficient even at less than 1 ppm
    Tobias Kind
    University of California Davis, Genome Center, Davis, CA 95616, USA
    BMC Bioinformatics 7:234. 2006
    ..This report demonstrates the necessity of isotope abundance information by mathematical confirmation of the concept...
  33. ncbi Functional discovery via a compendium of expression profiles
    T R Hughes
    Rosetta Inpharmatics, Inc, Kirkland, Washington 98034, USA
    Cell 102:109-26. 2000
    ..We also show that the compendium can be used to characterize pharmacological perturbations by identifying a novel target of the commonly used drug dyclonine...
  34. ncbi Drug target identification using side-effect similarity
    Monica Campillos
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Science 321:263-6. 2008
    ..Nine of these were tested and confirmed in cell assays, documenting the feasibility of using phenotypic information to infer molecular interactions and hinting at new uses of marketed drugs...
  35. pmc PharmGKB: the Pharmacogenetics Knowledge Base
    Micheal Hewett
    Stanford Medical Informatics, 251 Campus Drive, MSOB X 215, Stanford, CA 94305 5479, USA
    Nucleic Acids Res 30:163-5. 2002
    ..The PharmGKB project was initiated in April 2000 and the first version of the knowledge base went online in February 2001...
  36. pmc TRANSFAC: an integrated system for gene expression regulation
    E Wingender
    Gesellschaft fur Biotechnologische Forschung mbH, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Nucleic Acids Res 28:316-9. 2000
    ..Additionally, the databases TRANSPATH, about signal transduction, and CYTOMER, about organs and cell types, have been extended and are increasingly integrated with the TRANSFAC data sources...
  37. pmc The InterPro database, an integrated documentation resource for protein families, domains and functional sites
    R Apweiler
    EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 29:37-40. 2001
    ..The database is accessible for text- and sequence-based searches at http://www.ebi.ac.uk/interpro/. Questions can be emailed to interhelp@ebi.ac.uk...
  38. ncbi Issues in the registration of clinical trials
    Deborah A Zarin
    National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA
    JAMA 297:2112-20. 2007
    ....
  39. ncbi Feasibility study and methodology to create a quality-evaluated database of primary care data
    Alison Bourke
    The Health Improvement Network, London, UK
    Inform Prim Care 12:171-7. 2004
    ..To build and test a model for the collection of computerised retrospective primary care data from the UK, and to assess its quality for use in medical and pharmaceutical research...
  40. pmc LMSD: LIPID MAPS structure database
    Manish Sud
    LIPID MAPS Bioinformatics Core, San Diego Supercomputer Center San Diego, La Jolla, CA 92093, USA
    Nucleic Acids Res 35:D527-32. 2007
    ..Search results, in addition to structure and annotations, also include relevant links to external databases. The LMSD is publicly available at www.lipidmaps.org/data/structure/...
  41. pmc Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements
    A A Schaffer
    National Center for Biotechnology Information, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Nucleic Acids Res 29:2994-3005. 2001
    ..The use of composition-based statistics is particularly beneficial for large-scale automated applications of PSI-BLAST...
  42. pmc A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes
    Kasper Lage
    Center for Biological Sequence Analysis, Kemitorvet building 208, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Proc Natl Acad Sci U S A 105:20870-5. 2008
    ..Our method represents a conceptual scaffold for organism-spanning analyses and reveals an extensive list of tissue-specific draft molecular pathways, both known and unexpected, that might be disrupted in disease...
  43. ncbi Matrix2png: a utility for visualizing matrix data
    Paul Pavlidis
    Columbia Genome Center, Columbia University, New York, USA
    Bioinformatics 19:295-6. 2003
    ..In this note we describe some of matrix2png's features and describe some places it has been useful in the authors' work...
  44. pmc Overview of BioCreAtIvE: critical assessment of information extraction for biology
    Lynette Hirschman
    The MITRE Corporation, 202 Burlington Road, Bedford, MA 01730, USA
    BMC Bioinformatics 6:S1. 2005
    ..The articles collected in this BMC Bioinformatics supplement entitled "A critical assessment of text mining methods in molecular biology" describe the BioCreAtIvE tasks, systems, results and their independent evaluation...
  45. ncbi Global mapping of pharmacological space
    Gaia V Paolini
    The Department of Knowledge Discovery, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
    Nat Biotechnol 24:805-15. 2006
    ..The relationships between proteins, chemical structures and drug-like properties provide a framework for developing a probabilistic approach to drug discovery that can be exploited to increase research productivity...
  46. pmc An overview of the PubChem BioAssay resource
    Yanli Wang
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 38:D255-66. 2010
    ..In this work, we describe the PubChem BioAssay database, including data model, bioassay deposition and utilities that PubChem provides for searching, downloading and analyzing the biological activity information contained therein...
  47. ncbi Accuracy of Veterans Administration databases for a diagnosis of rheumatoid arthritis
    Jasvinder A Singh
    Minneapolis VA Medical Center and University of Minnesota, Minneapolis 55417, USA
    Arthritis Rheum 51:952-7. 2004
    ....
  48. pmc In-depth analysis of the thylakoid membrane proteome of Arabidopsis thaliana chloroplasts: new proteins, new functions, and a plastid proteome database
    Giulia Friso
    Department of Plant Biology, Cornell University, Ithaca, New York 14853, USA
    Plant Cell 16:478-99. 2004
    ..All data are deposited in a new curated plastid proteome database (PPDB) with multiple search functions (http://cbsusrv01.tc.cornell.edu/users/ppdb/). This PPDB will serve as an expandable resource for the plant community...
  49. ncbi Selected techniques for data mining in medicine
    N Lavrac
    Department of Intelligent Systems, J Stefan Institute, Ljubljana, Slovenia
    Artif Intell Med 16:3-23. 1999
    ..The importance of the interpretability of results of data analysis is discussed and illustrated on selected medical applications...
  50. pmc SuperNatural: a searchable database of available natural compounds
    Mathias Dunkel
    Berlin Center of Genome Based Bioinformatics, 3D Datamining Group, Institute of Biochemistry, Charite University Medicine Berlin, Monbijoustrasse 2, 10117 Berlin, Germany
    Nucleic Acids Res 34:D678-83. 2006
    ..charite.de/supernatural. Viewing requires the free Chime-plugin from MDL (Chime) or Java2 Runtime Environment (MView), which is also necessary for using Marvin application for chemical drawing...
  51. ncbi Data mining and clinical data repositories: Insights from a 667,000 patient data set
    Irene M Mullins
    Department of Public Health Sciences, University of Virginia Health System, Charlottesville, VA, USA
    Comput Biol Med 36:1351-77. 2006
    ..The initial results from this study suggest that these approaches have the potential to expand research capabilities through identification of potentially novel clinical disease associations...
  52. ncbi Diabetes and the risk of lung cancer
    Gillian C Hall
    Grimsdyke House, Ravenscroft Park, London, EN5 4ND, U K
    Diabetes Care 28:590-4. 2005
    ..We estimated the incidence of lung cancer in diabetic patients and investigated the hypothesis that the rate of lung cancer is different in diabetic compared with nondiabetic patients...
  53. ncbi A 3D structure database of components from Chinese traditional medicinal herbs
    Xuebin Qiao
    College of Chemical and Molecular Engineering, Beida Yang ShengTang Joint Laboratory for Natural Product, Peking University, Beijing 100871, China
    J Chem Inf Comput Sci 42:481-9. 2002
    ..We have tested it on the design of inhibitors of NS3-NS4A protease. Results show that the structure database of components extracted from Chinese medicinal herbs can be a rich source in searching the lead compound...
  54. ncbi An empirical comparison of record linkage procedures
    Shanti Gomatam
    University of South Florida, 4202 East Fowler Avenue, PHY 114, Tampa, FL 33620, USA
    Stat Med 21:1485-96. 2002
    ..Match rates and error rates for the two strategies are compared and a discussion of their similarities and differences, strengths and weaknesses is presented...
  55. ncbi HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei
    S Bonassi
    Department of Environmental Epidemiology, Istituto Nazionale per la Ricerca sul Cancro, 10 Largo R Benzi, Genoa I 16132, Italy
    Environ Mol Mutagen 37:31-45. 2001
    ..Our best model, which included exposure to genotoxic factors, host factors, methods, and scoring criteria, explained 75% of the total variance, with the largest contribution attributable to laboratory methods...
  56. pmc Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks
    Allan Peter Davis
    Department of Bioinformatics, The Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA
    Nucleic Acids Res 37:D786-92. 2009
    ..This wealth of chemical-gene-disease information yields testable hypotheses for understanding the effects of environmental chemicals on human health. CTD is freely available at http://ctd.mdibl.org...
  57. ncbi Relibase: design and development of a database for comprehensive analysis of protein-ligand interactions
    Manfred Hendlich
    Institute for Pharmaceutical Chemistry, Philipps University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany
    J Mol Biol 326:607-20. 2003
    ..g. acetylcholine-esterase, is discussed...
  58. ncbi Determinants of cardiovascular risk in 2589 hypopituitary GH-deficient adults - a KIMS database analysis
    Roger Abs
    Department of Endocrinology, University Hospital, Antwerp, Belgium
    Eur J Endocrinol 155:79-90. 2006
    ..The aim of the present study was to clarify the relationship between GH deficiency (GHD) and some cardiovascular risk factors and to analyse the effect of GH replacement therapy in a large number of patients over a prolonged period of time...
  59. ncbi Phanerozoic trends in the global diversity of marine invertebrates
    John Alroy
    National Center for Ecological Analysis and Synthesis, University of California Santa Barbara, 735 State Street, Santa Barbara, CA 93101, USA
    Science 321:97-100. 2008
    ..The ratio of global to local richness has changed little, and a latitudinal diversity gradient was present in the early Paleozoic...
  60. pmc STITCH: interaction networks of chemicals and proteins
    Michael Kuhn
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nucleic Acids Res 36:D684-8. 2008
    ..5 million genes across 373 genomes and their interactions contained in the STRING database. STITCH is available at http://stitch.embl.de/...
  61. pmc Molecular formula and METLIN Personal Metabolite Database matching applied to the identification of compounds generated by LC/TOF-MS
    Theodore R Sana
    Metabolomics Laboratory, Agilent Technologies, Santa Clara, CA 95051, USA
    J Biomol Tech 19:258-66. 2008
    ..In the event of no database match, it also suggests possible formulas that may be helpful in interpreting the experimental results...
  62. pmc SCMD: Saccharomyces cerevisiae Morphological Database
    Taro L Saito
    Department of Computer Science, Graduate School of Information Science and Technology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nucleic Acids Res 32:D319-22. 2004
    ..To search for mutants with similar morphological traits, the system outputs a list of mutants ranked by similarity of average morphological parameters. The SCMD is available at http://yeast. gi.k.u-tokyo.ac.jp/...
  63. ncbi Identifying splits with clear separation: a new class discovery method for gene expression data
    A von Heydebreck
    Division of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Ihnestr 73, D 14195 Berlin, Germany
    Bioinformatics 17:S107-14. 2001
    ..By analyzing three data sets from cancer gene expression studies, we demonstrate that our method is able to detect biologically relevant structures, for example cancer subtypes, in an unsupervised fashion...
  64. ncbi Protein structure prediction and structural genomics
    D Baker
    Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Science 294:93-6. 2001
    ..We then discuss the important role that protein structure prediction methods play in the growing worldwide effort in structural genomics...
  65. ncbi 'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries
    Paul D Dobson
    School of Chemistry and The Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN, UK
    Drug Discov Today 14:31-40. 2009
    ....
  66. pmc A journey to Semantic Web query federation in the life sciences
    Kei Hoi Cheung
    Center for Medical Informatics, Yale University School of Medicine, New Haven, CT 06511, USA
    BMC Bioinformatics 10:S10. 2009
    ....
  67. ncbi Moby and Moby 2: creatures of the deep (web)
    Ben P Vandervalk
    Department of Medical Genetics, The Providence Heart Lung Research Institute at St Paul s Hospital, University of British Columbia, Vancouver, British Columbia V6Z 1Y6, Canada
    Brief Bioinform 10:114-28. 2009
    ....
  68. ncbi Network analysis of protein structures identifies functional residues
    Gil Amitai
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Mol Biol 344:1135-46. 2004
    ..Closeness integrates the effect of the entire protein on single residues. Such natural structural design may be evolutionary maintained to preserve interaction redundancy and contribute to optimal setting of functional sites...
  69. pmc The global burden of injuries
    E G Krug
    World Health Organization, Geneva, Switzerland
    Am J Public Health 90:523-6. 2000
    ....
  70. ncbi Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry
    Miklos Feher
    SignalGene Inc, 335 Laird Road, Unit 2, Guelph, Ontario, N1G 4P7, Canada
    J Chem Inf Comput Sci 43:218-27. 2003
    ..It is suggested that by mimicking certain distribution properties of natural compounds, combinatorial products might be made that are substantially more diverse and have greater biological relevance...
  71. pmc Toxicology. Transforming environmental health protection
    Francis S Collins
    National Human Genome Research Institute NHGRI, National Institutes of Health, Bethesda, MD 20892, USA
    Science 319:906-7. 2008
  72. pmc Charting biologically relevant chemical space: a structural classification of natural products (SCONP)
    Marcus A Koch
    Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany
    Proc Natl Acad Sci U S A 102:17272-7. 2005
    ..11beta-hydroxysteroid dehydrogenase type 1 is a target in the development of new therapies for the treatment of diabetes, the metabolic syndrome, and obesity...
  73. ncbi A systematic review of the Charlson comorbidity index using Canadian administrative databases: a perspective on risk adjustment in critical care research
    Dale M Needham
    Department of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Crit Care 20:12-9. 2005
    ..Future research should focus on updating the Charlson index for recent changes in the prognosis of comorbid diseases and introduction of International Statistical Classification of Diseases, 10th Revision coding of discharge abstracts...
  74. pmc WikiPathways: pathway editing for the people
    Alexander R Pico
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    PLoS Biol 6:e184. 2008
  75. ncbi Comparative assessment of large-scale data sets of protein-protein interactions
    Christian von Mering
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69012 Heidelberg, Germany
    Nature 417:399-403. 2002
    ..To measure their accuracy and potential as well as to identify biases, strengths and weaknesses, we compare the methods with each other and with a reference set of previously reported protein interactions...
  76. pmc PolySearch: a web-based text mining system for extracting relationships between human diseases, genes, mutations, drugs and metabolites
    Dean Cheng
    Department of Computing Science, University of Alberta, Canada
    Nucleic Acids Res 36:W399-405. 2008
    ..Its f-measure on these tasks is 88, 81 and 79%, respectively. These values are between 5 and 50% better than other published tools. The server is freely available at http://wishart.biology.ualberta.ca/polysearch...
  77. ncbi Knowledge discovery in traditional Chinese medicine: state of the art and perspectives
    Yi Feng
    AdvanCed Computing aNd sysTem CCNT Lab, College of Computer Science, Zhejiang University, Hangzhou 310027, PR China
    Artif Intell Med 38:219-36. 2006
    ..This paper aims at providing an overview of recent KDD studies in TCM field...
  78. pmc An ontology for cell types
    Jonathan Bard
    Department of Biomedical Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh, EH8 9XD, UK
    Genome Biol 6:R21. 2005
    ..The ontology is freely available at http://obo.sourceforge.net/ and can be viewed using standard ontology visualization tools such as OBO-Edit and COBrA...
  79. pmc SGD: Saccharomyces Genome Database
    J M Cherry
    Department of Genetics, Stanford University, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 26:73-9. 1998
    ..SGD can be accessed via the World Wide Web at http://genome-www.stanford.edu/Saccharomyces/..
  80. pmc Are protein-protein interfaces more conserved in sequence than the rest of the protein surface?
    Daniel R Caffrey
    Pfizer Discovery Technology Center, Cambridge, Massachusetts 02139, USA
    Protein Sci 13:190-202. 2004
    ....
  81. ncbi Analysis of drug-induced effect patterns to link structure and side effects of medicines
    Anton F Fliri
    Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, USA
    Nat Chem Biol 1:389-97. 2005
    ..The identification of this alignment provides a mechanism for forecasting clinical effect profiles of medicines...
  82. pmc Towards a collaborative, global infrastructure for biodiversity assessment
    Robert P Guralnick
    Department of Ecology and Evolutionary Biology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Ecol Lett 10:663-72. 2007
    ..Our aim was to discuss how such tools, combined with data of enhanced quality, will help transform today's portals to raw biodiversity data into nexuses of collaborative creation and sharing of biodiversity knowledge...
  83. ncbi Minimum clinically important difference in lumbar spine surgery patients: a choice of methods using the Oswestry Disability Index, Medical Outcomes Study questionnaire Short Form 36, and pain scales
    Anne G Copay
    The Spinal Research Foundation, 1831 Wiehle Avenue, Suite 200, Reston, VA 20190, USA
    Spine J 8:968-74. 2008
    ..Variable threshold values have been proposed as MCID for those instruments despite a lack of agreement on the optimal MCID calculation method...
  84. pmc Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis
    M Bentele
    Division Theoretical Bioinformatics, German Caner Research Center DKFZ, Heidelberg 69120, Germany
    J Cell Biol 166:839-51. 2004
    ..Our model describes the regulation of apoptosis on a systems level and resolves the important question of a threshold mechanism for the regulation of apoptosis...
  85. ncbi A review of content-based image retrieval systems in medical applications-clinical benefits and future directions
    Henning Muller
    Service of Medical Informatics, University Hospital of Geneva, Rue Micheli du Crest 24, 1211 Geneva 14, Switzerland
    Int J Med Inform 73:1-23. 2004
    ..It needs to be stated as well that the goal is not, in general, to replace text-based retrieval methods as they exist at the moment but to complement them with visual search tools...
  86. ncbi PRIMe: a Web site that assembles tools for metabolomics and transcriptomics
    Kenji Akiyama
    RIKEN Plant Science Center, Yokohama, Kanagawa, Japan
    In Silico Biol 8:339-45. 2008
    ....
  87. pmc Big data: The future of biocuration
    Doug Howe
    The Zebrafish Information Network, 5291 University of Oregon, Eugene, Oregon 97403 5291, USA
    Nature 455:47-50. 2008
  88. ncbi Do structurally similar molecules have similar biological activity?
    Yvonne C Martin
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6100, USA
    J Med Chem 45:4350-8. 2002
    ..The current study emphasizes the statistical or probabilistic nature of library design and that perfect results cannot be expected...
  89. pmc ChEBI: a database and ontology for chemical entities of biological interest
    Kirill Degtyarenko
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nucleic Acids Res 36:D344-50. 2008
    ..ChEBI includes an ontological classification, whereby the relationships between molecular entities or classes of entities and their parents and/or children are specified. ChEBI is available online at http://www.ebi.ac.uk/chebi/..
  90. ncbi Nature of preventable adverse drug events in hospitals: a literature review
    Penkarn Kanjanarat
    Department of Pharmacy Health Care Administration, College of Pharmacy, University of Florida, HPNP Building, P O Box 100496, Gainesville, FL 32610 0496, USA
    Am J Health Syst Pharm 60:1750-9. 2003
    ..Targeting these high-priority areas could significantly reduce the overall frequency of pADEs...
  91. ncbi Alternative to hand-tuning conductance-based models: construction and analysis of databases of model neurons
    Astrid A Prinz
    Volen Center and Biology Department, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurophysiol 90:3998-4015. 2003
    ..In all cases, database searches can provide insight into how neuronal and network properties depend on the values of the parameters in the models...
  92. ncbi All-cause mortality rates in patients with type 1 diabetes mellitus compared with a non-diabetic population from the UK general practice research database, 1992-1999
    S S Soedamah-Muthu
    Department of Epidemiology and Public Health, Royal Free and University College London Medical School, London, UK
    Diabetologia 49:660-6. 2006
    ..We compiled up to date estimates of the absolute and relative risk of all-cause mortality in patients with type 1 diabetes in the UK...
  93. ncbi Validity of diagnostic and drug data in standardized nursing home resident assessments: potential for geriatric pharmacoepidemiology. SAGE Study Group. Systematic Assessment of Geriatric drug use via Epidemiology
    G Gambassi
    Istituto di Medicina Interna e Geriatria, Universita Cattolica del Sacro Cuore, Rome, Italy
    Med Care 36:167-79. 1998
    ..The authors sought to ascertain reliability and validity of diagnostic and drug data in a database obtained by merging the Minimum Data Set with detailed information on drugs consumed by each resident...
  94. pmc Sequence mapping by electronic PCR
    G D Schuler
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20984, USA
    Genome Res 7:541-50. 1997
    ....
  95. ncbi Bisque: a platform for bioimage analysis and management
    Kristian Kvilekval
    Center for Bio image Informatics, Electrical and Computer Engineering Department, University of California Santa Barbara, CA, USA
    Bioinformatics 26:544-52. 2010
    ..These obstacles have resulted in research resources being locked away in digital media and file cabinets. Current image management systems do not address the pressing needs of researchers who must quantify image data on a regular basis...
  96. ncbi Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physicochemical properties, compound classes, and drug discove
    Tobias Fink
    Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH 3012 Berne, Switzerland
    J Chem Inf Model 47:342-53. 2007
    ..The potential of GDB for drug discovery is illustrated by virtual screening for kinase inhibitors, G-protein coupled receptor ligands, and ion-channel modulators. The database is available from the author's Web page...
  97. ncbi Life sciences on the Semantic Web: the Neurocommons and beyond
    Alan Ruttenberg
    Informatics Institute, University of Amsterdam, Amsterdam, The Netherlands
    Brief Bioinform 10:193-204. 2009
    ..All components of the knowledge base are freely available at http://neurocommons.org/, enabling readers to reconstruct the knowledge base and experiment with this new technology...
  98. pmc BioGeomancer: automated georeferencing to map the world's biodiversity data
    Robert P Guralnick
    Department of Ecology and Evolutionary Biology and CU Museum at the University of Colorado, Boulder, Colorado, United States of America
    PLoS Biol 4:e381. 2006
  99. pmc The Arabidopsis Information Resource (TAIR): a comprehensive database and web-based information retrieval, analysis, and visualization system for a model plant
    E Huala
    Carnegie Institution, Department of Plant Biology, 260 Panama Street, Stanford, CA 94305, USA
    Nucleic Acids Res 29:102-5. 2001
    ..This paper describes the initial steps we have taken toward realizing these goals in a project called The Arabidopsis Information Resource (TAIR) (www.arabidopsis.org)...
  100. ncbi The Life Sciences Semantic Web is full of creeps!
    Benjamin M Good
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Vancouver, BC
    Brief Bioinform 7:275-86. 2006
    ....
  101. ncbi Ligand-target prediction using Winnow and naive Bayesian algorithms and the implications of overall performance statistics
    Florian Nigsch
    Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom
    J Chem Inf Model 48:2313-25. 2008
    ..This provided detailed information that can never be obtained by considering the overall performance statistics alone...

Research Grants90

  1. EXAMINING NURSING HOME COMPARE
    Nicholas Castle; Fiscal Year: 2005
    ..abstract_text> ..
  2. Are Volume Standards Accurate Measures of Quality?
    Laurent Glance; Fiscal Year: 2005
    ..abstract_text> ..
  3. INCIDENT REPORTING IN NURSING HOMES
    Nicholas Castle; Fiscal Year: 2008
    ..This information will further our development of a standardized incident reporting mechanism recommended by the Institute of Medicine and others. [unreadable] [unreadable] [unreadable]..
  4. Staffing Characteristics of Nursing Homes and Quality
    Nicholas Castle; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  5. Interoperation of Genome Databases and Tools
    Kei Hoi Cheung; Fiscal Year: 2005
    ..We will extend our approach to other types of genomic data such as microarray data, which both laboratories and others will soon be generating in large quantities. ..
  6. EVALUATION OF OSTEOARTHRITIS-RELATED WORK DISABILITY
    Saralynn Allaire; Fiscal Year: 2004
    ..This study will provide information about whom to target for knee OA-related work disability interventions and indicate the kinds of interventions that are likely to be needed to reduce work disability in this population. ..
  7. Lymphoma in Autoimmune Disease: Consequence of Immune Suppression or Stimulation?
    Sasha Bernatsky; Fiscal Year: 2008
    ..Our proposed project will help identify patients at highest risk for lymphoma and provide guidance regarding initiation and maintenance of therapy to control SLE. [unreadable] [unreadable] [unreadable]..
  8. The Influence of Staff Turnover on Quality
    Nicholas Castle; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. Data Consistency Based Motion Artifact Reduction for Head CT
    Hengyong Yu; Fiscal Year: 2008
    ..Hence, the proposed techniques promise to be translated for clinical use and should generate great healthcare benefits, especially for children. [unreadable] [unreadable] [unreadable]..
  10. Ergonomic Interventions for Garment Work
    Beate Ritz; Fiscal Year: 2004
    ..This study will provide employers, employees and public agencies with evidence of the effectiveness of ergonomic interventions in order to guide health and safety policy. ..
  11. Automated Literature Mining for Validation of High-Throughput Function Prediction
    KARIN MARIA VERSPOOR; Fiscal Year: 2010
    ..It is time to truly integrate the biological literature into the protein function prediction problem. By doing so, we will enable a critical advance in high-throughput protein function prediction ..
  12. Behavioral Health Effects of September 11th, 2001
    Charles DiMaggio; Fiscal Year: 2006
    ..abstract_text> ..
  13. Alcohol Intake on Insulin Sensitivity and Heart Disease
    Sun Kim; Fiscal Year: 2006
    ..Given the morbidity and mortality of insulin resistance and CVD, it becomes important to clarify the role of moderate alcohol consumption to both. ..
  14. The Mental Lexicon of Children with Phonological Delays
    HOLLY STORKEL; Fiscal Year: 2006
    ..abstract_text> ..
  15. Arrest Patterns Among Youth in Mental Health Systems
    Maryann Davis; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  16. Randomized Controlled Testing of Osteoporosis Education
    Daniel Solomon; Fiscal Year: 2006
    ..A multi-disciplinary Training Advisory Board will review the applicants progress regularly to ensure that the proposed training goals are met. ..
  17. Molecular Mechanisms in Chrondrosarcoma Metastasis
    Sean Scully; Fiscal Year: 2008
    ..It is also plausible that lessons learned in the proposed studies of chondrosarcoma can be applicable to a wider spectrum of neoplastic processes. ..
  18. Gene Expression in Barrett's Esophagus
    Hashem El Serag; Fiscal Year: 2006
    ..We present preliminary data on microarray and RT-PCRanalyses on 5 patients with BE that suggest an overactive Wnt pathway: we have also assembled the essential components of a successful study using microarrays. ..
  19. Algorithms for protein superfamily classification and function prediction
    Degui Zhi; Fiscal Year: 2008
    ..Our computational approach will speed up the discovery of biological knowledge from large data sets generated by high-throughput methods. [unreadable] [unreadable] [unreadable]..
  20. Diabetes and Drug-Associated Hyperkalemia: Effect of Laboratory Monitoring
    Marsha Raebel; Fiscal Year: 2008
    ..The findings will also assist in developing a framework for future studies to evaluate the effects and costs of medication-laboratory monitoring among patients with diabetes. [unreadable] [unreadable] [unreadable] [unreadable]..
  21. DELAY OF GRATIFICATION--SUBSTANCE USE/ABUSE/DEPENDENCE
    Kevin Chen; Fiscal Year: 2003
    ..Significant implications for drug prevention and treatment programs, and for the study of other health-related behaviors are anticipated. ..
  22. HEALTH/SAFETY IMPACT OF ONTARIOS DRINKING HOURS
    Evelyn Vingilis; Fiscal Year: 2001
    ..Alcohol-related casualties for both cities will be subjected to time-series analyses. In addition, Detroit data will be disaggregated to analyze the trends of alcohol-related casualties involving Ontario drivers. ..
  23. SOY PROTEIN +/- ISOFLAVONOIDS AND PLASMA LIPIDS
    Alice Lichtenstein; Fiscal Year: 2002
    ..The results of these studies, whether positive or negative, should contribute to the data base on which to formulate more specific public health recommendations with respect to decreasing risk of developing CHD. ..
  24. PARAMEDIC FIELD INITIATION OF MAGNESIUM NEUROPROTECTIVE
    Jeffrey Saver; Fiscal Year: 2003
    ..abstract_text> ..
  25. Phase 3 stem cell transplant for light chain amyloidosis
    Morie A Gertz; Fiscal Year: 2011
    ..In addition, the analysis of clonal precursor B cells in the periphery and kinetics of amyloid formation of the monoclonal light chain will allow us to define and determine the mechanisms of disease progression and response to therapy. ..
  26. Implementation of Asthma Guidelines in Primary Care; Comparison of 4 approaches
    James W Mold; Fiscal Year: 2010
    ..If effective, the same strategies could be used to facilitate implementation of other chronic disease guidelines. ..
  27. Naturalistic Assessment of the Driving ability of Cognitively Impaired Elders
    BRIAN RICHARD OTT; Fiscal Year: 2010
    ....
  28. Prospective Huntington At Risk Observational Study (PHAROS)
    Ira Shoulson; Fiscal Year: 2009
    ..The knowledge will also inform how persons at high risk to develop a disabling genetic disease deal with lingering uncertainties about their future health and complex choices about their participation in research. ..
  29. COMPUTER AIDED DIAGNOSIS IN CT OF THE THORAX
    Samuel Armato; Fiscal Year: 2004
    ....
  30. Signal Detection for Prescription Opioid Outbreaks
    Stephen Butler; Fiscal Year: 2008
    ..This system should be perceived by stakeholders as highly valuable. Thus, we believe this product has enormous commercial viability and public health importance. [unreadable] [unreadable] [unreadable] [unreadable]..
  31. Combining Data from the NHIS and BRFSS
    Michael Elliott; Fiscal Year: 2004
    ..This approach is particularly promising because, in contrast to other proposed techniques, it can be applied using existing publicly available data. ..
  32. Obesity, Metabolic Syndrome, Meal-Related Glycemia
    Barry E Hurwitz; Fiscal Year: 2010
    ..This research is an essential step toward understanding in persons with MSX the role of postprandial glycemic regulation in accelerated CHD pathogenesis. ..
  33. Psychiatric barriers to outpatient care in released HIV-infected offenders
    Jacques Baillargeon; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Antifolates as Antimalarial Drugs
    CAROL SIBLEY; Fiscal Year: 2007
    ..We think that this in depth understanding of antifolate action in the parasites will ensure that WR99210 will be developed as a useful drug for the long haul against P. falciparum and P. vivax. ..
  35. A Developmental Multi-Informant Measurement Model of Temperament
    Kirby Deater Deckard; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  36. A Unified Surgical Instrument System for Periodontal Minimally Invasive Surgery
    STEPHEN HARREL; Fiscal Year: 2007
    ..The resulting system, based on the surgical consultants evaluations and scores, will be used in a Phase 2 multicenter controlled clinical evaluation of MIS. [unreadable] [unreadable] [unreadable]..
  37. DRUG ABUSE, HIV, SELENIUM SUPPLEMENTATION, AND CVD RISK
    Barry Hurwitz; Fiscal Year: 2006
    ..abstract_text> ..
  38. Using Clinically-Enhanced Claims Data to Guide Selection of Coronary Procedures
    HAROLD KILBURN; Fiscal Year: 2010
    ....
  39. Effects of Methamphetamine in Traumatic Brain Injury
    KRISTINE O PHELAN; Fiscal Year: 2007
    ..This will help inform public education and prevention efforts in this area. It may also allow the development of specific therapeutic strategies for this population of patients. [unreadable] [unreadable] [unreadable]..
  40. Collecting duct endothelin-1 and hypertension
    Donald Kohan; Fiscal Year: 2009
    ..Such information is important in understanding intrarenal mechanisms responsible for hypertension and salt and water retention. ..
  41. Word Learning in Children: Normal Development and Language Impairment
    Holly L Storkel; Fiscal Year: 2010
    ..Thus, effective word learning instruction is critical in preventing reading and academic failure. Theoretically motivated diagnostic and treatment methods may minimize this risk. ..
  42. Pain Assessment Interview and Clinical Advisory System
    Stephen Butler; Fiscal Year: 2008
    ..Thus, we believe this product has enormous commercial viability and public health importance. [unreadable] [unreadable] [unreadable] [unreadable]..
  43. Industrial Pollutants and Risk of Non-Hodgkins Lymphoma
    Anneclaire De Roos; Fiscal Year: 2006
    ..abstract_text> ..
  44. Asthma and Invasive Pneumococcal Disease
    Young Juhn; Fiscal Year: 2006
    ..abstract_text> ..
  45. Short & Long Term Suicide Risk Factors
    Mark Kaplan; Fiscal Year: 2005
    ..The results of this epidemiologic study, will help us better understand proximal and distal suicide risk factors. ..
  46. Cholesterol Homeostasis in Framingham Offspring Study
    Alice Lichtenstein; Fiscal Year: 2006
    ..abstract_text> ..
  47. THE MENTAL LEXICON IN LANGUAGE ACQUISITION
    HOLLY STORKEL; Fiscal Year: 2005
    ..The findings to emerge hold potential for theories of word learning and the relationship between perception and production in language acquisition. ..
  48. HIV/HCV Co-infection: HAART and CVD Pathophysiology
    Barry Hurwitz; Fiscal Year: 2006
    ..abstract_text> ..
  49. Strategies to reduce time to reperfusion therapy for MI
    Harlan Krumholz; Fiscal Year: 2005
    ..Data generated from these studies will guide efforts by clinicians, administrators, researchers, and policy makers to decrease time to reperfusion therapy for patients with STEMI. ..
  50. Screening for Addiction Risk in Chronic Opioid Therapy
    Stephen Butler; Fiscal Year: 2005
    ..Substantial Phase III support has been committed by Endo Pharmaceuticals. The resulting measure should be reliable, valid, and easy to use in practice settings. ..
  51. SYMPTOMS OF TRANSPLANT PATIENTS NEAR THE END OF LIFE
    Karen Anderson; Fiscal Year: 2003
    ..It is predicted that patients in the experimental condition who die during the year will demonstrate better symptom management and quality of the end of life than patients in the control condition. ..
  52. DIETARY FAT, PLASMA LIPIDS AND OTHER CHD RISK FACTORS.
    Alice Lichtenstein; Fiscal Year: 2003
    ..The investigators state that data derived from the proposed studies could contribute to the database on which to formulate more specific public health recommendations regarding the variables described. ..
  53. The Balanced Budget Act of 1997 and Home Care for Cancer
    Meredith Kilgore; Fiscal Year: 2006
    ..Data generated from this study can be used to guide federal decision makers in formulating policies related to home health services for older cancer patients. ..
  54. Temporal Integration in Nasal Lateralization
    Paul Wise; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  55. Osteoporosis in Women with Rheumatoid Arthritis
    Daniel Solomon; Fiscal Year: 2006
    ..This epidemiologic data will inform future trials of osteoporosis treatments among patients with RA. As well, the study cohort will comprise one of the largest RA registries with an explicit plan to examine osteoporosis. ..
  56. ISEE 19th Annual Conference
    Daniel Wartenberg; Fiscal Year: 2007
    ..ISEE provides a variety of forums for discussion, critical reviews, collaborations and education issues for environmental exposures and their human health effects. [unreadable] [unreadable] [unreadable] [unreadable]..
  57. CORI: Consortium Expansion and Database Enhancement
    David Lieberman; Fiscal Year: 2004
    ....
  58. Screening for colortectal cancer in an Asian Community Center
    David Lieberman; Fiscal Year: 2008
    ..This is a new paradigm for screening, which takes advantage of the trust and cultural awareness that exists at the community center and does not rely on the primary care provider. [unreadable] [unreadable] [unreadable] [unreadable]..
  59. Ethnicity and the Diagnosis of Affective Illness
    Michael Gara; Fiscal Year: 2008
    ..The final objective is to determine whether Latinos are at risk for similar problems in diagnostic assessments and treatment assignment. ..
  60. LABOR MARKET OUTCOMES OF LONG TERM CANCER SURVIVORS
    Cathy Bradley; Fiscal Year: 2004
    ....
  61. Impact of Nurse Work Environment on Rural Quality of Care and Clinical Outcomes
    Marianne Baernholdt; Fiscal Year: 2009
    ....
  62. Biomarkers of Peripheral Arterial Disease
    Iftikhar Kullo; Fiscal Year: 2007
    ..abstract_text> ..
  63. TREATMENT OF SOMATIZATION IN PRIMARY CARE
    Michael Gara; Fiscal Year: 2004
    ..In spite of the relatively high prevalence of somatization in this group, to our knowledge, there are no controlled trials of the effectiveness of treatments for somatization in the Latino community. ..
  64. Spatial epidemiology of diabetes in the SEARCH for Diabetes in Youth Study
    ANGELA LIESE; Fiscal Year: 2009
    ..This effort may provide novel leads for subsequent etiologic studies of pediatric diabetes and will assist health care planners in identifying geographic areas in particular need of health services resources. ..
  65. OVERWEIGHT STATUS AFTER CHILDBIRTH
    Lorraine Walker; Fiscal Year: 2003
    ....
  66. SUPPLEMENTAL OXYGEN AND SURGICAL WOUND INFECTIONS
    Daniel Sessler; Fiscal Year: 2001
    ..Since the cost of oxygen is trivial and the risks of oxygen administration are low, clinicians will easily be able to implement this treatment once we have demonstrated its benefits. ..
  67. Determinants of arterial function in hypertension
    Iftikhar J Kullo; Fiscal Year: 2010
    ..The aim of our investigation is to identify novel proteins and genes that influence arterial function. Such work will help in identifying those at risk of developing arterial disease and facilitate development of new therapies. ..
  68. Functional Arterial Changes in Atherogenesis
    Iftikhar Kullo; Fiscal Year: 2007
    ..abstract_text> ..
  69. Energy Balance, Organochlorine Exposure, and Possible Toxicologic Effects
    Anneclaire De Roos; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  70. Heart Failure: Epidemiology & Outcomes in the Elderly
    Lesley Curtis; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  71. Nitrous Oxide and Wound Infections
    Ozan Akca; Fiscal Year: 2006
    ..Confirming our hypothesis would thus allow clinicians to make a minor modification in anesthetic practice that might reduce the incidence of a complication responsible for considerable perioperative morbidity and cost. ..
  72. Distinguishing the neural bases of lexical access
    William Graves; Fiscal Year: 2005
    ..This study should lead to a more complete neural account of lexical access. ..
  73. Reducing Postpartum Weight Retention Among Low Income, Ethnically Diverse Women
    Lorraine Walker; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  74. WEB BASED RENAL TRANSPLANT PATIENT MEDICATION EDUCATION
    Amy Friedman; Fiscal Year: 2006
    ..It is hoped that better prescription comprehension and understanding of the transplant process will help patients improve their own compliance and troubleshoot errors made by other providers. ..
  75. TRUCKING FIRM CHARACTERISTICS, DRIVER INJURY AND OUTCOME
    Arthur Oleinick; Fiscal Year: 2003
    ..Predictive value is evaluated by ROC curves, the Bayes Information Criteria or other recommended approaches. ..
  76. Collaboration on Specific Language Impairment
    JAMES TOMBLIN; Fiscal Year: 2005
    ..abstract_text> ..
  77. ISEE 18th Annual Meeting in Conjunction with ISEA
    Daniel Wartenberg; Fiscal Year: 2006
    ..ISEE provides a variety of forums for discussion, critical reviews, collaborations and education issues for environmental exposures and their human health effects. [unreadable] [unreadable] [unreadable] [unreadable]..
  78. The Genetics of Specific Language Impairment
    JAMES TOMBLIN; Fiscal Year: 2009
    ..The phenotypes and endophenotypes from these individuals will then be used in conjunction with the existing genotyping for additional genome-wide screens and further follow-up fine mapping studies. ..
  79. 14th Annual HMO Research Network Conference
    Robert Greenlee; Fiscal Year: 2008
    ..The agenda will be closely aligned with AHRQ's mission to improve the quality, safety, efficiency, and effectiveness of health care. [unreadable] [unreadable] [unreadable]..
  80. Preschool Vision Screening in Primary Care Settings
    Alex Kemper; Fiscal Year: 2007
    ....
  81. Using MEPS Data to Inform Public-Plan Consumerism
    Matthew Davis; Fiscal Year: 2007
    ..Findings will have immediate relevance for implementation of the HOA projects and other consumerism efforts. [unreadable] [unreadable] [unreadable]..
  82. BILINGUAL PRESCHOOLERS--PRECURSORS TO LITERACY
    Carol Hammer; Fiscal Year: 2004
    ....
  83. SIMULATION RESOURCE IN CIRCULATORY MASS TRANSPORT
    James Bassingthwaighte; Fiscal Year: 2006
    ..Section D.IV. provides core support for software development, simulation and modeling analysis, training, and the dissemination of NSR deliverables. ..
  84. Capture-Recapture Estimates of Workplace Injury Rates
    LESLIE BODEN; Fiscal Year: 2004
    ....
  85. Linking Federal and State Data to Study the Economic Effects of Workplace Injury
    LESLIE BODEN; Fiscal Year: 2009
    ....
  86. Web-based CBT for Chronic Pain in Children
    Tonya Palermo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  87. Public Health Model to Promote Safe Elderly Driving
    Sherrilene Classen; Fiscal Year: 2006
    ..abstract_text> ..
  88. Conference--ISEE 16th Annual Meeting
    Daniel Wartenberg; Fiscal Year: 2004
    ..ISEE provides a variety of forums for discussion, critical reviews, collaborations and education issues for environmental exposures and their human health effects. ..