survival rate

Summary

Summary: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

Top Publications

  1. ncbi Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer
    David Cunningham
    Department of Medicine, Royal Marsden Hospital, Sutton, Surrey, United Kingdom
    N Engl J Med 355:11-20. 2006
  2. ncbi The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours
    Peter Goldstraw
    Royal Brompton Hospital, Imperial College, London, United Kingdom
    J Thorac Oncol 2:706-14. 2007
  3. pmc Final version of 2009 AJCC melanoma staging and classification
    Charles M Balch
    Department of Surgery, Oncology and Dermatology, Johns Hopkins Medical Institutions, 600 N Wolfe St, Osler 624, Baltimore, MD, 21287, USA
    J Clin Oncol 27:6199-206. 2009
  4. ncbi The epidemiology of sepsis in the United States from 1979 through 2000
    Greg S Martin
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, USA
    N Engl J Med 348:1546-54. 2003
  5. ncbi Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
    Arjen Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Lancet 366:717-25. 2005
  6. ncbi Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine
    Shinichi Sakuramoto
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    N Engl J Med 357:1810-20. 2007
  7. doi Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    Roger Stupp
    Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Lancet Oncol 10:459-66. 2009
  8. ncbi Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    David W Andrews
    Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Lancet 363:1665-72. 2004
  9. ncbi A 5-decade analysis of 13,715 carcinoid tumors
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 97:934-59. 2003
  10. ncbi Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging
    Jessica B O'Connell
    Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Ave, Rm 72 215 CHS, Los Angeles, CA 90095, USA
    J Natl Cancer Inst 96:1420-5. 2004

Detail Information

Publications376 found, 100 shown here

  1. ncbi Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer
    David Cunningham
    Department of Medicine, Royal Marsden Hospital, Sutton, Surrey, United Kingdom
    N Engl J Med 355:11-20. 2006
    ..We assessed whether the addition of a perioperative regimen of ECF to surgery improves outcomes among patients with potentially curable gastric cancer...
  2. ncbi The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours
    Peter Goldstraw
    Royal Brompton Hospital, Imperial College, London, United Kingdom
    J Thorac Oncol 2:706-14. 2007
    ..The recommendations of this committee for changes to the T, N, and M descriptors have been published. This report contains the proposals for the new stage groupings...
  3. pmc Final version of 2009 AJCC melanoma staging and classification
    Charles M Balch
    Department of Surgery, Oncology and Dermatology, Johns Hopkins Medical Institutions, 600 N Wolfe St, Osler 624, Baltimore, MD, 21287, USA
    J Clin Oncol 27:6199-206. 2009
    ..To revise the staging system for cutaneous melanoma on the basis of data from an expanded American Joint Committee on Cancer (AJCC) Melanoma Staging Database...
  4. ncbi The epidemiology of sepsis in the United States from 1979 through 2000
    Greg S Martin
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, USA
    N Engl J Med 348:1546-54. 2003
    ..We investigated the epidemiology of sepsis in the United States, with specific examination of race and sex, causative organisms, the disposition of patients, and the incidence and outcome...
  5. ncbi Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
    Arjen Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Lancet 366:717-25. 2005
    ..In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of parasite clearance, is safer, and is simpler to administer, but whether it can reduce mortality is uncertain...
  6. ncbi Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine
    Shinichi Sakuramoto
    Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    N Engl J Med 357:1810-20. 2007
    ..Advanced gastric cancer can respond to S-1, an oral fluoropyrimidine. We tested S-1 as adjuvant chemotherapy in patients with curatively resected gastric cancer...
  7. doi Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    Roger Stupp
    Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Lancet Oncol 10:459-66. 2009
    ..We report the final results with a median follow-up of more than 5 years...
  8. ncbi Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    David W Andrews
    Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Lancet 363:1665-72. 2004
    ..We aimed to assess whether stereotactic radiosurgery provided any therapeutic benefit in a randomised multi-institutional trial directed by the Radiation Therapy Oncology Group (RTOG)...
  9. ncbi A 5-decade analysis of 13,715 carcinoid tumors
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 97:934-59. 2003
    ....
  10. ncbi Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging
    Jessica B O'Connell
    Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles, 10833 Le Conte Ave, Rm 72 215 CHS, Los Angeles, CA 90095, USA
    J Natl Cancer Inst 96:1420-5. 2004
    ..Using nationally representative Surveillance, Epidemiology, and End Results (SEER) data, we compared survival rates associated with colon cancer stages defined according to both AJCC systems...
  11. ncbi Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer
    Rodrigo Arriagada
    Instituto de Radiomedicina, Santiago, Chile
    N Engl J Med 350:351-60. 2004
    ..On the basis of a previous meta-analysis, the International Adjuvant Lung Cancer Trial was designed to evaluate the effect of cisplatin-based adjuvant chemotherapy on survival after complete resection of non-small-cell lung cancer...
  12. ncbi Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    E Kapiteijn
    Department of Surgery, Leiden University Medical Center, The Netherlands
    N Engl J Med 345:638-46. 2001
    ..2 percent in the surgery-only group (P<0.001). CONCLUSIONS: Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision...
  13. ncbi Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols
    Stefan S Bielack
    Klinik und Poliklinik für Kinderheilkunde, Pädiatrische Hämatologie Onkologie, Universitatsklinikum, Munster, Germany
    J Clin Oncol 20:776-90. 2002
    ..To define prognostic factors for response and long-term outcome for a wide spectrum of osteosarcomas, extending well beyond those of the typical young patient with seemingly localized extremity disease...
  14. ncbi Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction
    J S Macdonald
    St Vincent's Comprehensive Cancer Center, New York, USA
    N Engl J Med 345:725-30. 2001
    ..CONCLUSIONS: Postoperative chemoradiotherapy should be considered for all patients at high risk for recurrence of adenocarcinoma of the stomach or gastroesophageal junction who have undergone curative resection...
  15. ncbi Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer
    Umberto Veronesi
    Department of Senology, European Institute of Oncology, Milan, Italy
    N Engl J Med 347:1227-32. 2002
    ..We conducted 20 years of follow-up of women enrolled in a randomized trial to compare the efficacy of radical (Halsted) mastectomy with that of breast-conserving surgery...
  16. doi S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial
    Wasaburo Koizumi
    Kitasato University School of Medicine, Sagamihara, Japan
    Lancet Oncol 9:215-21. 2008
    ....
  17. ncbi DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
    Ken A Olaussen
    Laboratory of Radiobiology and Oncology, Commissariat a l Energie Atomique, Fontenay aux Roses, University of Paris 11, Paris, France
    N Engl J Med 355:983-91. 2006
    ..Adjuvant cisplatin-based chemotherapy improves survival among patients with completely resected non-small-cell lung cancer, but there is no validated clinical or biologic predictor of the benefit of chemotherapy...
  18. ncbi Long-term trends in the incidence of and survival with heart failure
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    N Engl J Med 347:1397-402. 2002
    ..Heart failure is a major public health problem. Long-term trends in the incidence of heart failure and survival after its onset in the community have not been characterized...
  19. pmc Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control
    Ahmedin Jemal
    Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30303 1002, USA
    J Natl Cancer Inst 100:1672-94. 2008
    ..This year's report includes trends in lung cancer incidence and death rates, tobacco use, and tobacco control by state of residence...
  20. doi Long-term results from a randomized phase II trial of standard- versus higher-dose imatinib mesylate for patients with unresectable or metastatic gastrointestinal stromal tumors expressing KIT
    Charles D Blanke
    Oregon Health and Science University Cancer Center and Portland Veterans Affairs Hospital, Portland, OR, USA
    J Clin Oncol 26:620-5. 2008
    ..We conducted a long-term analysis of patients treated on the trial, including patients followed during an extension phase, to evaluate survival, patterns of failure, and potential prognostic factors, including tumor mutational status...
  21. doi Lower survival rate, longevity and fecundity of Aedes aegypti (Diptera: Culicidae) females orally challenged with dengue virus serotype 2
    R Maciel-de-Freitas
    Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz, FIOCRUZ, Avenida Brasil 4365, 21040 360, Rio de Janeiro, RJ, Brazil
    Trans R Soc Trop Med Hyg 105:452-8. 2011
    ..28 in the first clutch to 20.7 in the fifth. Overall, DENV-2 reduced Aedes aegypti survival and fecundity, clearly affecting vectorial capacity and consequently transmission intensity...
  22. doi Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States
    Anil K Chaturvedi
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Clin Oncol 26:612-9. 2008
    ....
  23. doi Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial
    Yung Jue Bang
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
    Lancet 379:315-21. 2012
    ..We investigated the effect on disease-free survival of adjuvant chemotherapy with capecitabine plus oxaliplatin after D2 gastrectomy compared with D2 gastrectomy only in patients with stage II-IIIB gastric cancer...
  24. ncbi Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer
    Jacques Bernier
    Department of Radio Oncology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
    N Engl J Med 350:1945-52. 2004
    ..We compared concomitant cisplatin and irradiation with radiotherapy alone as adjuvant treatment for stage III or IV head and neck cancer...
  25. ncbi Trends in prevalence and outcome of heart failure with preserved ejection fraction
    Theophilus E Owan
    Cardiorenal Research Laboratory, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    N Engl J Med 355:251-9. 2006
    ..We performed a study to define secular trends in the prevalence of heart failure with preserved ejection fraction among patients at a single institution over a 15-year period...
  26. ncbi Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome
    Herve Avet-Loiseau
    INSERM Unité 601, Laboratoire d Hematologie, Institut de Biologie, 9 quai Moncousu, 44093 Nantes, France
    Blood 109:3489-95. 2007
    ..In myeloma, the genomic aberrations t(4;14) and del(17p), together with beta2-microglobulin level, are important independent predictors of survival. These findings have implications for the design of risk-adapted treatment strategies...
  27. ncbi Cancer statistics, 2005
    Ahmedin Jemal
    Department of Epidemiology and Research Surveillance, American Cancer Society, Atlanta, GA, USA
    CA Cancer J Clin 55:10-30. 2005
    ..Progress in reducing the burden of suffering and death from cancer can be accelerated by applying existing cancer control knowledge across all segments of the population...
  28. ncbi Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    Malcolm J Moore
    Division of Medical Oncology, Princess Margaret Hospital, Toronto, Canada
    J Clin Oncol 25:1960-6. 2007
    ..We studied the effects of adding the HER1/EGFR-targeted agent erlotinib to gemcitabine in patients with unresectable, locally advanced, or metastatic pancreatic cancer...
  29. ncbi Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma
    K Kian Ang
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:7350-6. 2002
    ..The data suggest that EGFR IHC should be considered for selecting patients for more aggressive combined therapies or enrollment into trials targeting EGFR signaling pathways...
  30. doi Long-term outcomes of early-stage nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy alone
    Sheng fa Su
    State Key Laboratory of Oncology in Southern China, Guangzhou, People s Republic of China
    Int J Radiat Oncol Biol Phys 82:327-33. 2012
    ..The present study evaluated the long-term survival outcomes and toxicity of early-stage NPC patients treated with IMRT alone...
  31. ncbi International staging system for multiple myeloma
    Philip R Greipp
    Mayo Clinic College of Medicine and Eastern Cooperative Oncology Group, Rochester, MN, USA
    J Clin Oncol 23:3412-20. 2005
    ..There is a need for a simple, reliable staging system for multiple myeloma that can be applied internationally for patient classification and stratification...
  32. doi Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033
    Charles D Blanke
    Oregon Health and Science University Cancer Institute, 3181 SW Sam Jackson Park Rd, L 586, Portland, OR 97239, USA
    J Clin Oncol 26:626-32. 2008
    ....
  33. ncbi Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    Jason G Wood
    Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 430:686-9. 2004
    ..Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction...
  34. pmc Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
    Bryan P Schneider
    Indiana University School of Medicine, Indianapolis, IN, USA
    J Clin Oncol 26:4672-8. 2008
    ..Therefore, we evaluated the association of VEGF genotype with efficacy and toxicity in E2100, a phase III study comparing paclitaxel versus paclitaxel plus bevacizumab as initial chemotherapy for metastatic breast cancer...
  35. ncbi Current epidemiology of septic shock: the CUB-Réa Network
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculte de Medecine Paris Ile de France Ouest, Université de Versaille Saint Quentinen Yvelinnes, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Am J Respir Crit Care Med 168:165-72. 2003
    ..The frequency of septic shock is increasing with more multiresistant strains. Its crude mortality rate is decreasing, but patients with septic shock still have a high excess risk of death than critically ill patients who are nonseptic...
  36. ncbi Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience
    Anne W M Lee
    Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, 3 Lok Man Road, Chai Wan, Hong Kong, China
    Int J Radiat Oncol Biol Phys 61:1107-16. 2005
    ..To analyze the treatment results achievable for nasopharyngeal carcinoma in the modern era to identify the key failures for future improvement and to provide an updated baseline for future trials...
  37. ncbi Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: a meta-analysis of the published results of randomized clinical trials
    Richard J Sylvester
    European Organisation for Research and Treatment of Cancer Data Center, Brussels, Belgium
    J Urol 168:1964-70. 2002
    ..We determine if intravesical bacillus Calmette-Guerin (BCG) reduces the risk of progression after transurethral resection to stage T2 disease or higher in patients with superficial (stage Ta, T1 or carcinoma in situ) bladder cancer...
  38. ncbi Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis
    Val Gebski
    National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia
    Lancet Oncol 8:226-34. 2007
    ..We aimed to clarify the benefits of neoadjuvant chemoradiotherapy or chemotherapy versus surgery alone by a meta-analysis of randomised trial data...
  39. ncbi CNS metastases in breast cancer
    Nancy U Lin
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 22:3608-17. 2004
    ..Studies specifically targeted toward this group of patients are needed...
  40. ncbi Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    Nick Thatcher
    Medical Oncology, Christie Hospital NHS Trust, Manchester M20 4BX, UK
    Lancet 366:1527-37. 2005
    ..This placebo-controlled phase III study investigated the effect on survival of gefitinib as second-line or third-line treatment for patients with locally advanced or metastatic non-small-cell lung cancer...
  41. ncbi Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089
    T E Le Voyer
    Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Clin Oncol 21:2912-9. 2003
    ..To determine the relationship, in patients with adenocarcinoma of the colon, between survival and the number of lymph nodes analyzed from surgical specimens...
  42. ncbi Origins of socio-economic inequalities in cancer survival: a review
    L M Woods
    Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK
    Ann Oncol 17:5-19. 2006
    ..Differences were most commonly attributed to differences in stage of disease at diagnosis...
  43. ncbi Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    Stephen G O'Brien
    University of Newcastle, Newcastle, United Kingdom
    N Engl J Med 348:994-1004. 2003
    ..We compared the efficacy of imatinib with that of interferon alfa combined with low-dose cytarabine in newly diagnosed chronic-phase CML...
  44. ncbi Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial) [corrected]
    Masahiro Fukuoka
    Fourth Department of Internal Medicine, Kinki University School of Medicine, 377 2 Ohnohigashi Osakasayama, Osaka 589, Japan
    J Clin Oncol 21:2237-46. 2003
    ....
  45. ncbi Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points
    I F Tannock
    Department of Medicine, Princess Margaret Hospital, Toronto, Canada
    J Clin Oncol 14:1756-64. 1996
    ..To investigate the benefit of chemotherapy in patients with symptomatic hormone-resistant prostate cancer using relevant end points of palliation in a randomized controlled trial...
  46. doi Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma
    Regina V Tse
    Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 26:657-64. 2008
    ..To report outcomes of a phase I study of individualized stereotactic body radiotherapy treatment (SBRT) for unresectable hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHC)...
  47. pmc A prospective randomized trial comparing percutaneous local ablative therapy and partial hepatectomy for small hepatocellular carcinoma
    Min shan Chen
    Department of Hepatobiliary Surgery, Cancer Centre of Sun Yat sen University, Guangzhou, China
    Ann Surg 243:321-8. 2006
    ..To compare the results of percutaneous local ablative therapy (PLAT) with surgical resection in the treatment of solitary and small hepatocellular carcinoma (HCC)...
  48. ncbi Factors predictive of survival among 337 patients with mesothelioma treated between 1984 and 1994 by the Cancer and Leukemia Group B
    J E Herndon
    CALGB Statistical Center, Department of Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 113:723-31. 1998
    ..To examine the individual and joint effect of various pretreatment clinical characteristics on the survival of patients with mesothelioma treated by the Cancer and Leukemia Group B (CALGB)...
  49. ncbi Hepatocellular carcinoma
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Liver Unit, Digestive Disease Institute, IDIBAPS, Hospital Cli nic i Provincial, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain
    Lancet 362:1907-17. 2003
    ..Meta-analysis shows that only chemoembolisation improves survival in well-selected patients with unresectable HCC...
  50. doi First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
    Lecia V Sequist
    Massachusetts General Hospital Cancer Center, 32 Fruit St, Yawkey Suite 7B, Boston, MA 02114, USA
    J Clin Oncol 26:2442-9. 2008
    ..The multicenter iTARGET trial prospectively examined first-line gefitinib in advanced NSCLC patients harboring EGFR mutations and explored the significance of EGFR mutation subtypes and TKI resistance mechanisms...
  51. doi Recent patterns in gastric cancer: a global overview
    Paola Bertuccio
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int J Cancer 125:666-73. 2009
    ..Steady downward trends persist in gastric cancer mortality worldwide even in middle aged population, and hence further appreciable declines are likely in the near future...
  52. ncbi High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation
    Stephanie J Lee
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Blood 110:4576-83. 2007
    ..High-resolution DNA matching for HLA-A, -B, -C, and -DRB1 alleles is associated with higher rates of survival...
  53. pmc Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995-2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data
    M P Coleman
    Cancer Research UK Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 377:127-38. 2011
    ..This is the first study in a programme to investigate international survival disparities, with the aim of informing health policy to raise standards and reduce inequalities in survival...
  54. ncbi Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer
    S R Walsh
    Department of Colorectal Surgery, West Suffolk Hospital NHS Trust, UK
    J Surg Oncol 91:181-4. 2005
    ..Simple methods to identify colorectal cancer patients at risk of recurrence are needed. This study aimed to determine if neutrophil-to-lymphocyte ratio (NLR) predicts survival in colorectal cancer patients...
  55. ncbi Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
    Eric Van Cutsem
    University Hospital Gasthuisberg, Leuven, Belgium
    J Clin Oncol 30:3499-506. 2012
    ....
  56. ncbi Early mortality among adults accessing a community-based antiretroviral service in South Africa: implications for programme design
    Stephen D Lawn
    The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Cape Town, South Africa
    AIDS 19:2141-8. 2005
    ..To determine rates, risk factors and causes of death among patients accessing a community-based antiretroviral treatment (ART) programme both prior to and following initiation of treatment...
  57. doi Pretreatment serum C-reactive protein level predicts poor prognosis in patients with hepatocellular carcinoma
    Akiyoshi Kinoshita
    Division of Gastroenterology and Hepatology, The Jikei University Daisan Hospital, 4 11 1 Izumihon cho, Komae shi, Tokyo, 201 8601, Japan
    Med Oncol 29:2800-8. 2012
    ..Our results demonstrate that the pretreatment serum CRP level is associated with tumor progression and reduced liver function and is an independent poor prognostic marker in patients with HCC...
  58. ncbi Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial
    Jean Yves Douillard
    Centre Rene Gauducheau, Nantes, France
    Lancet Oncol 7:719-27. 2006
    ..We aimed to compare the effect of adjuvant vinorelbine plus cisplatin versus observation on survival in patients with completely resected NSCLC...
  59. doi The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer
    Takeharu Yamanaka
    Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan
    Oncology 73:215-20. 2007
    ..The objective of our study was to determine the prognostic implications of the N/L ratio in the peripheral blood of gastric cancer patients...
  60. doi The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status
    Anna M Dahlin
    Department of Medical Biosciences, Pathology, and Department of Surgical and Perioperative Sciences, Surgery, Umea University, Umea, Sweden
    Clin Cancer Res 16:1845-55. 2010
    ....
  61. ncbi Characterization of intraperitoneal, orthotopic, and metastatic xenograft models of human ovarian cancer
    Tanya J Shaw
    Ottawa Regional Cancer Centre, Department of Cellular and Molecular Medicine, University of Ottawa, ON, Canada K1H 1C4
    Mol Ther 10:1032-42. 2004
    ..The animal models described herein represent histologically distinct models of both early and late stage ovarian cancer useful for evaluation of therapeutics...
  62. doi Pathologic complete response after neoadjuvant chemotherapy plus trastuzumab predicts favorable survival in human epidermal growth factor receptor 2-overexpressing breast cancer: results from the TECHNO trial of the AGO and GBG study groups
    Michael Untch
    Helios Klinikum Berlin Buch, Schwanebecker Chaussee 50, 13125 Berlin, Germany
    J Clin Oncol 29:3351-7. 2011
    ..To evaluate efficacy and safety of epirubicin and cyclophosphamide followed by paclitaxel and trastuzumab as neoadjuvant treatment in patients with human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer...
  63. ncbi Diabetes mellitus after kidney transplantation in the United States
    Bertram L Kasiske
    The United States Renal Data System Coordinating Center, Minneapolis, MN, USA
    Am J Transplant 3:178-85. 2003
    ..It is a strong, independent predictor of graft failure and mortality. Efforts should be made to minimize the risk of this important complication...
  64. pmc Patterns of initial recurrence in completely resected gastric adenocarcinoma
    Michael D'Angelica
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Ann Surg 240:808-16. 2004
    ..To review recurrence patterns in completely resected gastric adenocarcinoma...
  65. pmc Liver resection for hepatocellular carcinoma on cirrhosis: univariate and multivariate analysis of risk factors for intrahepatic recurrence
    Giorgio Ercolani
    Department of Surgery and Transplantation, Surgical Unit, S Orsola Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Ann Surg 237:536-43. 2003
    ..To evaluate prognostic factors that could affect disease-free survival and recurrence after liver resection for hepatocellular carcinoma (HCC) on cirrhosis...
  66. pmc Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival
    Rene Adam
    Centre Hépato Biliaire and Inserm E0354 Cancer Chronotherapeutics, Hopital Paul Brousse, Assistance Publique Hopitaux de Paris Université Paris, Sud Villejuif, France
    Ann Surg 240:644-57; discussion 657-8. 2004
    ....
  67. ncbi Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
    A M Clement
    Ludwig Institute for Cancer Research, University of California, 9500 Gilman Drive, La Jolla, CA 92093 0670, USA
    Science 302:113-7. 2003
    ..Normal motor neurons in SOD1 mutant chimeras develop aspects of ALS pathology. Most important, nonneuronal cells that do not express mutant SOD1 delay degeneration and significantly extend survival of mutant-expressing motor neurons...
  68. ncbi Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
    Amar Gajjar
    Department of Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Lancet Oncol 7:813-20. 2006
    ..We aimed to investigate the effectiveness of risk-adapted radiotherapy followed by a shortened period of dose-intense chemotherapy in children with medulloblastoma...
  69. doi Complete cytoreductive surgery plus intraperitoneal chemohyperthermia with oxaliplatin for peritoneal carcinomatosis of colorectal origin
    Dominique Elias
    Département de Chirurgie Carcinologique, Institut Gustave Roussy, Villejuif, France
    J Clin Oncol 27:681-5. 2009
    ....
  70. ncbi More 'malignant' than cancer? Five-year survival following a first admission for heart failure
    S Stewart
    Clinical Research Initiative in Heart Failure, University of Glasgow, G12 8QQ, Glasgow, UK
    Eur J Heart Fail 3:315-22. 2001
    ..The prognostic impact of heart failure relative to that of 'high-profile' disease states such as cancer, within the whole population, is unknown...
  71. ncbi Gene-expression profiles predict survival of patients with lung adenocarcinoma
    David G Beer
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Nat Med 8:816-24. 2002
    ..The identification of a set of genes that predict survival in early-stage lung adenocarcinoma allows delineation of a high-risk group that may benefit from adjuvant therapy...
  72. doi Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781
    Joel Tepper
    Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7512, USA
    J Clin Oncol 26:1086-92. 2008
    ..To this end, we compared survival, response, and patterns of failure of trimodality therapy to esophagectomy alone in patients with nonmetastatic esophageal cancer...
  73. pmc One thousand consecutive pancreaticoduodenectomies
    John L Cameron
    Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Ann Surg 244:10-5. 2006
    ..To trace the evolution of pancreaticoduodenectomy from the decade of the 1960s through the first decade of the new Millenium, through the experience of one surgeon doing 1000 consecutive operations...
  74. doi Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer
    Cornelia Liedtke
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 1439, USA
    J Clin Oncol 26:1275-81. 2008
    ..In this study, we compared response to neoadjuvant chemotherapy and survival between patients with TNBC and non-TNBC...
  75. ncbi Prognostic staging system for hepatocellular carcinoma (CLIP score): its value and limitations, and a proposal for a new staging system, the Japan Integrated Staging Score (JIS score)
    Masatoshi Kudo
    Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama 589 8511, Japan
    J Gastroenterol 38:207-15. 2003
    ..Because the JIS score is quite easily obtained and is objective, we strongly propose it for widespread use as a prognostic staging system for HCC in clinical practice...
  76. ncbi Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer
    Anna Bergamaschi
    Department of Genetics, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Genes Chromosomes Cancer 45:1033-40. 2006
    ..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat..
  77. ncbi Overdiagnosis due to prostate-specific antigen screening: lessons from U.S. prostate cancer incidence trends
    Ruth Etzioni
    Program in Biostatistics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Natl Cancer Inst 94:981-90. 2002
    ..Overdiagnosis was defined as the detection of prostate cancer through PSA testing that otherwise would not have been diagnosed within the patient's lifetime...
  78. ncbi Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients
    J P Stein
    Department of Urology, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA 90089, USA
    J Clin Oncol 19:666-75. 2001
    ....
  79. ncbi Rising incidence of small renal masses: a need to reassess treatment effect
    John M Hollingsworth
    Michigan Urology Center, University of Michigan, Ann Arbor, MI, USA
    J Natl Cancer Inst 98:1331-4. 2006
    ..The fact that increased detection and treatment of small tumors is not reducing mortality argues for a reassessment of the current treatment paradigm...
  80. ncbi Phase III comparison of two irinotecan dosing regimens in second-line therapy of metastatic colorectal cancer
    Charles S Fuchs
    Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Clin Oncol 21:807-14. 2003
    ..We prospectively compared the efficacy and tolerability of two irinotecan regimens (once a week for 4 weeks followed by a 2-week rest period [weekly] v once every 3 weeks) in such patients...
  81. pmc Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case-control study
    Tania M Welzel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Clin Gastroenterol Hepatol 5:1221-8. 2007
    ..Because the etiology of both tumors is poorly understood, a population-based case-control study was conducted to examine the association of ECC and ICC with preexisting medical conditions...
  82. doi Effect of the number of lymph nodes sampled on postoperative survival of lymph node-negative esophageal cancer
    Alexander J Greenstein
    Department of General Surgery, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer 112:1239-46. 2008
    ..In the current study, the association between survival and the number of LNs evaluated was examined in patients who underwent resection of lymph node-negative (American Joint Committee on Cancer [AJCC] TNM stage I-IIA) esophageal cancer...
  83. ncbi Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small-cell lung cancer: Four-Arm Cooperative Study in Japan
    Y Ohe
    Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan
    Ann Oncol 18:317-23. 2007
    ..To compare the efficacy and toxicity of three platinum-based combination regimens against cisplatin plus irinotecan (IP) in patients with untreated advanced non-small-cell lung cancer (NSCLC) by a non-inferiority design...
  84. ncbi Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
    Hiroko Ohgaki
    Pathology Group, International Agency for Research on Cancer HO, F 69372, Lyon, France
    J Neuropathol Exp Neurol 64:479-89. 2005
    ..G:C-->A:T mutations at CpG sites were more frequent in secondary than primary glioblastomas, suggesting that the acquisition of TP53 mutations in these glioblastoma subtypes may occur through different mechanisms...
  85. doi Acute-on-chronic kidney injury at hospital discharge is associated with long-term dialysis and mortality
    Vin Cent Wu
    Division of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Kidney Int 80:1222-30. 2011
    ..These outcomes were significantly worse in those with unresolved AKI at discharge...
  86. ncbi Surgery of colorectal cancer: surgical morbidity and five- and ten-year results in 2400 patients--monoinstitutional experience
    Ludger Staib
    Department of General and Visceral Surgery, University of Ulm, Steinhovelstrasse 9, 89070 Ulm Donau, Germany
    World J Surg 26:59-66. 2002
    ..The morbidity and mortality were low and were not increased by multivisceral resections...
  87. doi Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer
    Mi Ran Jung
    Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Medical School, Gwangju, Korea
    J Surg Oncol 104:504-10. 2011
    ..Elevated neutrophil to lymphocyte ratio (N/L ratio) has been shown to be a prognostic indicator in various cancers. We aimed to investigate the prognostic significance of the preoperative N/L ratio in late stage gastric cancer...
  88. doi Impact of the clinical conditions at dialysis initiation on mortality in incident haemodialysis patients: a national cohort study in Taiwan
    Shang Jyh Hwang
    Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    Nephrol Dial Transplant 25:2616-24. 2010
    ..We studied factors potentially related to the mortality in incident haemodialysis (HD) patients...
  89. ncbi Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies
    Gennaro D'Amico
    Gastroenterology Unit, Ospedale Cervello and University of Palermo, Italy
    J Hepatol 44:217-31. 2006
  90. doi Risk stratification of patients diagnosed with gastrointestinal stromal tumor
    Heikki Joensuu
    Department of Oncology, Helsinki University Central Hospital, FIN 00029 Helsinki, Finland
    Hum Pathol 39:1411-9. 2008
    ..The proposed system, if validated, may be useful in identifying which patients might potentially benefit from adjuvant therapy...
  91. pmc Mortality results from the Göteborg randomised population-based prostate-cancer screening trial
    Jonas Hugosson
    Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy at University of Göteborg, Sweden
    Lancet Oncol 11:725-32. 2010
    ..One strategy to decrease the risk of death from this disease is screening with prostate-specific antigen (PSA); however, the extent of benefit and harm with such screening is under continuous debate...
  92. doi Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
    Pierre Fenaux
    Service d Hematologie Clinique, Hospital Avicenne, Assistance Publique Hopitaux de Paris AP HP, Universite Paris XIII, Bobigny, France
    J Clin Oncol 28:562-9. 2010
    ..Approximately one third of these patients were classified as having acute myeloid leukemia (AML) under current WHO criteria. This analysis compared the effects of azacitidine versus CCR on OS in this subgroup...
  93. ncbi FOXA1 expression in breast cancer--correlation with luminal subtype A and survival
    Sunil Badve
    Department of Pathology, Indiana University School of Medicine, Indianapolis, USA
    Clin Cancer Res 13:4415-21. 2007
    ..It segregates with genes that characterize the luminal subtypes in DNA microarray analyses. The utility of FOXA1 as a possible independent prognostic factor has not been determined in breast cancers...
  94. ncbi Prognostic factors for stage III epithelial ovarian cancer: a Gynecologic Oncology Group Study
    William E Winter
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brooke Army Medical Center, Ft Sam
    J Clin Oncol 25:3621-7. 2007
    ..The purpose of this study was to identify factors predictive of poor prognosis in a similarly treated population of women with advanced EOC...
  95. ncbi Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial
    Ka Lau Leung
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Lancet 363:1187-92. 2004
    ..We aimed to test the null hypothesis that there was no difference in survival after laparoscopic and open resection for rectosigmoid cancer...
  96. ncbi Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer
    Monika Schindl
    Institute of Clinical Pathology, Department of Surgery, University of Vienna Medical School, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Clin Cancer Res 8:1831-7. 2002
    ..The aim of this study was to determine the prognostic influence of HIF-1alpha expression in patients with advanced-stage breast cancer, evident by positive lymph nodes...
  97. doi Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas
    Harriet C Hafkamp
    Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Int J Cancer 122:2656-64. 2008
    ..from TSCC and that non-smoking patients with HPV-containing TSCC show a remarkably better disease-specific survival rate. HPV 16 is integrated in 41% of TSCC and strongly correlates with p16(INK4A) overexpression, implicating the ..
  98. ncbi Small hepatocellular carcinoma in cirrhosis: randomized comparison of radio-frequency thermal ablation versus percutaneous ethanol injection
    Riccardo A Lencioni
    Division of Diagnostic and Interventional Radiology, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Via Roma 67, I 56125 Pisa, Italy
    Radiology 228:235-40. 2003
    ..To compare the effectiveness of radio-frequency (RF) thermal ablation with that of percutaneous ethanol injection (PEI) for the treatment of small hepatocellular carcinoma (HCC) in patients with cirrhosis...
  99. ncbi Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer
    H Ueno
    Department of Surgery I, National Defence Medical College, Saitama, Japan
    Histopathology 40:127-32. 2002
    ..As another histological parameter of invasive margin, we examined the prognostic significance of tumour 'budding' and attempted to establish its appropriate criteria...
  100. pmc Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients
    G Pérez-Tenorio
    Department of Biomedicine and Surgery, Division of Oncology, Clinical Research Center, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Br J Cancer 86:540-5. 2002
    ..004). The results suggest that activation of Akt may have prognostic relevance in breast cancer...
  101. doi Incidence, prevalence and mortality trends of dialysis end-stage renal disease in Taiwan from 1990 to 2001: the impact of national health insurance
    Wu Chang Yang
    Division of Nephrology, Department of Medicine, Taipei Veteran General Hospital, School of Medicine, National Yang Ming University Taipei 11217, Taiwan
    Nephrol Dial Transplant 23:3977-82. 2008
    ..Our aim was to explore the impact of NHI on the status and trends of ESRD epidemiology in Taiwan...

Research Grants79

  1. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..Although advances in surgery, and combined of radio and chemotherapies, have decreased morbidity, the survival rate at 5 years after initial prognosis remains at <50%...
  2. Wireless At-Risk Infant Monitoring System
    JASON HOLMSTEDT; Fiscal Year: 2012
    ..While neonatology and neonatal intensive care units (NICUs) have greatly raised the survival rate of at-risk, very low birth weight, and extremely premature infants, approximately 30,000 American babies under ..
  3. Overcoming Temozolomide Resistance using MGMT-targeting Spherical Nucleic Acids
    TIMOTHY L SITA; Fiscal Year: 2013
    ..Patients with a methylated promoter region have a much higher two-year survival rate (49%) than patients without a methylated MGMT promoter region (15%)...
  4. Antibody-mediated Gene Therapy for the Treatment of Cancer
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..MCL comprises 5-10% of NHL cases, has a median survival of about 4 years, and a long- term survival rate of less than 15%, which has not significantly changed in the past 20 years...
  5. Enhancing radiation and cisplatin HNSCC cell killing by inhibiting mitochondrial
    Lynn Harrison; Fiscal Year: 2013
    ..The overall survival rate is only ~40%, and ~30% of advanced stage disease has locoregional recurrence...
  6. Mechanisms of TGFB Signal Transduction
    Akiko Hata; Fiscal Year: 2013
    ..by applicant): Idiopathic pulmonary arterial hypertension (IPAH) is a rare but terminal disease with a median survival rate of 2-3 years from the time of diagnosis if left untreated...
  7. New drug Vida-5 for treating chronic kidney disease progression
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2011
    ..Despite the various treatments available, the five-year survival rate is ~33% and the mortality risk increases with kidney disease progression and secondary hyperparathyroidism...
  8. Novel drug VS-105 for treatment of diabetic nephropathy
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..Despite the various treatments available, the five-year survival rate is ~33% and the mortality risk increases with kidney disease progression and secondary hyperparathyroidism...
  9. Addressing Psychosocial Disparities in Rural Hispanic Cancer Survivors
    Rachel M Ceballos; Fiscal Year: 2013
    ..Research Plan. Among Hispanics, the 5-year cause-specific survival rate across all stages of female reproductive cancers (breast, uterine, cervical, ovarian) has been steadily ..
  10. Validation of a multi-gene test for lung cancer risk
    James C Willey; Fiscal Year: 2010
    ..men and women in the United States with cigarette smoking being the primary known risk factor and has a low survival rate in part because it typically is at an advanced stage when first detected and treated...
  11. Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia
    Andrew Napper; Fiscal Year: 2012
    ..acute lymphocytic leukemia (ALL), where it is found in half of all cases and results in a five-year event-free survival rate of only 34%...
  12. Metabolic Syndrome and Breast Cancer: Effects of a Combined Exercise Intervention
    Christina Dieli-Conwright; Fiscal Year: 2013
    ..Breast cancer is a prevalent disease which due to medical and scientific advances has a high survival rate. However, serious breast cancer treatment side effects such as weight gain persist during survivorship and ..
  13. A Pilot Study of Yoga for Breathing and Quality of Life of Lung Cancer Patients
    JUDITH MARIE FOULADBAKHSH; Fiscal Year: 2013
    ..Although the 5-year survival rate has slowly increased for non-small cell lung cancer (NSCLC) patients, excessive symptom burden due to stage at ..
  14. Prevention of Esophageal Cancer with Berries
    Gary Stoner; Fiscal Year: 2013
    ..This disease has a poor prognosis with a 5-year survival rate of about 12%...
  15. Cancer induction in the ovary by an environmental pollutant, dibenzo[a,l]pyrene
    Kun Ming Chen; Fiscal Year: 2013
    ..by applicant): There are usually no obvious symptoms of early stage ovarian cancer;therefore, the five-year survival rate for ovarian cancer patients is 44%...
  16. Identification of Biomarkers for Early Detection of Renal Cell Carcinoma
    Othon Iliopoulos; Fiscal Year: 2012
    ..about 30% of kidney cancer patients present with metastatic disease at the time of diagnosis and the 5-year survival rate for these patients is approximately 5%...
  17. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine J Gudas; Fiscal Year: 2013
    ..The overall survival rate for SCCHN of approximately 50% in five years has not changed very much in recent decades, so there is a major ..
  18. Development of New Therapeutics for Pancreatic Cancer Management
    RICHARD JOSEPH PIETRAS; Fiscal Year: 2013
    ..The overall 5- year survival rate is less than 5%, and effective therapies are largely lacking...
  19. PPAR gamma Agonists for Lung Cancer Chemoprevention
    Robert Keith; Fiscal Year: 2013
    ..The cumulative five-year survival rate for lung cancer is 15%, a rate which has shown limited improvement over the last several decades...
  20. Treatment of breast cancer tumor growth and metastasis with an anti-MMP-9 DNAzyme
    MIRANDA A HALLETT; Fiscal Year: 2011
    ..3) The effect of DNAzyme treatment on the survival rate of animals bearing breast carcinomas will be assessed...
  21. Diet and Alcohol Induced Epigenetic Changes in Oral Cavity Carcinogenesis Model
    Lorraine J Gudas; Fiscal Year: 2013
    ..The overall survival rate for human SCCHN (approximately 50% in five years) has not changed very much in recent decades, so there is an ..
  22. Gutless Adenovirus Mediated Gene Therapy for Glioma
    Maria G Castro; Fiscal Year: 2011
    ..Having met all previous milestones, we propose to file for FDA approval towards the end of this U01 proposal. ..
  23. Autologous EPC lining to improve biocompatibility of circulatory assist devices
    Jeffrey H Lawson; Fiscal Year: 2010
    ..in medical therapy, the mortality rate in these patients has remained extremely high, with a 5-year median survival rate of only 25% in men and 38% in women...
  24. Slow cycling brain tumor cancer stem cells
    BRENT REYNOLDS; Fiscal Year: 2010
    ..The project should unveil the stem cell characteristics of brain tumor cells and provide insight in how to regulate the behavior of the cancer cells. ..
  25. Biomarkers of Aggressive Oral Cancer
    THEKKELNAYCKE RAJENDIRAN; Fiscal Year: 2013
    ..SCC, the most common malignant oral neoplasm, accounts for 90% of all oral malignancies and has a poor 5-year survival rate that has not changed in decades (http://seer/cancer...
  26. Mechanisms of trauma and hemorrhage-induced impairment of innate immunity
    Xiao Di Tan; Fiscal Year: 2013
    ..of post-hemorrhaged mice with Pseudonumo aeruginosa followed by assessing the clinical course including survival rate, bacteremia, tissue injury, and inflammatory and cytokine response...
  27. Manipulation of Host Angiogenesis as a Therapeutic Strategy against Invasive Pulm
    Dimitrios P Kontoyiannis; Fiscal Year: 2010
    ..therapeutic administration of pro-angiogenic growth factors together with antifungal drugs will increase the survival rate in experimental IA by increasing the tissue concentrations of the antifungal drugs...
  28. PPARgamma and PPARgamma agonists in septic shock
    Basilia Zingarelli; Fiscal Year: 2013
    ..Interestingly, treatment with an AMPK activator was able to ameliorate liver function and improve early survival rate in septic old mice...
  29. Oxidative Burst in Influenza and MRSA Co-infection
    Keer Sun; Fiscal Year: 2013
    ..data demonstrated that combination treatment with antibiotic and NOX2 inhibitor significantly improved the survival rate of influenza and MRSA co-infected mice compared with antibiotic treatment alone...
  30. Development of Novel Agents Targeting Genome Stability and Maintenance for Treati
    John J Turchi; Fiscal Year: 2013
    ..These courses of disease progression result in an overall 5 year survival rate of 46%...
  31. Impact of exercise on ovarian cancer prognosis
    Melinda L Irwin; Fiscal Year: 2013
    ..However, improvements in surgical techniques and chemotherapy have led to an increase in the 5-year survival rate from 37% in 1976 to 45% in 2006...
  32. Genome Wide Admixture Scan for Multiple Myeloma in African Americans
    CHRISTOPHER ALAN HAIMAN; Fiscal Year: 2013
    ..Despite recent advances in treatment, the 5-year survival rate remains under 40%...
  33. Keratin biomaterial-based fluid for trauma resuscitation
    LUKE BURNETT; Fiscal Year: 2010
    ..power (LVP), ventricular-arteriol coupling (VAC), and arterial diameter, and] a statistically significant survival rate of at least 80% in the keratin treated groups compared to groups treated with conventional resuscitation ..
  34. Cath B and uPAR si RNA constructs regressed glioma growth
    JOHN P O'BRYAN; Fiscal Year: 2013
    ..applicant): Despite the many therapeutic strategies undertaken for treatment of glioblastoma multiforme, the survival rate remains low for patients afflicted with this aggressive cerebral malignancy...
  35. Epidemiologic Study of Hepatocellular Carcinoma in the US
    Herbert Yu; Fiscal Year: 2013
    ..Five-year survival rate of the disease is only 10%. The incidence of HCC has been steadily rising in the US...
  36. Improvement of Organ Function after Severe Hypovolemia
    Ping Wang; Fiscal Year: 2013
    ..Anti-rmCIRP antibodies also improve the survival rate from 43% to 85% after hemorrhage and fluid resuscitation...
  37. Plasma RNA based Early Lung Cancer Detection by Tethered Cationic Lipoplex Assay
    SERGE P NANA-SINKAM; Fiscal Year: 2013
    ..Lung cancer is the leading cause of cancer deaths worldwide with a disappointing 15% overall 5-year survival rate. A patient-friendly early detection and surveillance method would substantially reduce the mortality in this ..
  38. Intravascular Cardiac Assist System for Decompression and Recovery
    CAITLYN J BOSECKER; Fiscal Year: 2010
    ..for patients who are not candidates for cardiac transplantation, mechanical support increased not only the survival rate, but also scores on physical and emotional tests at one year compared to patients treated with medication...
  39. Mapping Expression Quantitative Trait Loci with Next Generation Sequencing in SLE
    Min Chen; Fiscal Year: 2013
    ..While the survival rate has been greatly enhanced due to advances in research on the mechanisms of the disease and aggressive therapy, ..
  40. MECHANISMS OF ALLOGENEIC STEM CELL EDUCATION IN SCID
    Rebecca H Buckley; Fiscal Year: 2010
    ..4 years, with an overall survival rate of 77%. Aim yB the of these elevated f'0 .O-., 0_q Coo 3on1 nip SCID chimeras...
  41. Novel lysine deacetylase 6 Hsp domain inhibitors against AML
    CHUNG JEN JAMES CHOU; Fiscal Year: 2013
    ..Greater than 5 year survival rate still remains around 10-30%, and this depends greatly on the patient's ability to tolerate the ..
  42. Cellular and molecular mechanisms of gp120 neurotoxicity
    Italo Mocchetti; Fiscal Year: 2012
    ..Endocytosis of gp120 is followed by axonal transport through microtubules. The length of axons and survival rate of neurons that do not internalize gp120 is significantly greater when compared to those accumulating gp120...
  43. Small Interfering RNAs: Inhibition of Oral Carcinogenesis in a Mouse Model
    Lorraine J Gudas; Fiscal Year: 2010
    Squamous cell carcinoma (SCC) of the oral cavity is one of the most common cancers in the world. The long-term survival rate for this cancer is only about 50%...
  44. Novel prognostic microRNA biomarkers for primary sclerosing cholangitis
    Kris Kowdley; Fiscal Year: 2013
    ..liver transplantation is currently considered the only curative option for PSC and results an excellent 5 year survival rate of 86% in PSC patients...
  45. Discovery of Novel Antitumor Agents Effective Against Pancreatic Cancer
    Amy E Wright; Fiscal Year: 2012
    ..new combination chemotherapeutic regimes coupled with surgery have resulted in an overall increase in mean survival rate, but even so, fewer than 5% of patients diagnosed with pancreatic cancer will survive five years post ..
  46. Role and Function of RNA-Binding Protein La in Oral Tumor Progression
    Gunhild Sommer; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The 5-year survival rate of oral cavity cancer is poorer than breast, colon, or prostate cancer, and has only slightly improved by 5% in the last three decades...
  47. ELUCIDATING THE FUNCTION OF MATRIPTASE-ACTIVATED PDGF D IN BONE METASTATIC PROSTA
    ABDO JAMAL NAJY; Fiscal Year: 2012
    ..Relevance: Although early detection has improved prostate cancer survival rate, many patients still exhibit metastatic disease at diagnosis...
  48. Novel small-molecule inhibitors of Wee1 kinase for medulloblastoma treatment
    Philip Reigan; Fiscal Year: 2013
    ..of high-risk patients with Myc amplification who continue to have an extremely poor prognosis with a 5-year survival rate of less than 30%...
  49. Mitochondrial Kv1.3 potassium channels and lymphocyte apoptosis in sepsis
    Jay Yang; Fiscal Year: 2011
    ..If the lost T lymphocytes can be replenished the organism may be able to fight the infection and increase the survival rate. The key role of plasma membrane Kv1...
  50. Role of PUMA in EGFR targeted therapy in HNSCC
    Jian Yu; Fiscal Year: 2012
    ..The survival rate of HNSCC patients has not been significantly improved over the past 30 years with conventional therapies...
  51. FOUR-DIMENSIONAL MRI FOR IMAGE-GUIDED RADIATION THERAPY FOR PANCREATIC CANCER
    Yanle Hu; Fiscal Year: 2013
    ..It has very poor prognosis. The five year survival rate is only 6%. Approximately 30% of pancreatic cancer patients die with locally destructive pancreatic cancer...
  52. Therapeutic Efficacy of Flaxseed in the Treatment of Ovarian Cancer
    Dale B Hales; Fiscal Year: 2013
    ..Due to the late stage at which the disease is usually diagnosed the survival rate is very low and conventional treatment modalities or intervention strategies are usually ineffective...
  53. Role of Reishi on cell surface proteins and signaling modulation in IBC
    IVETTE SUAREZ; Fiscal Year: 2013
    ..Cancer (IBC) is one of the most lethal forms of breast cancer, where patients show less than a five percent survival rate beyond five years when treated with surgery or radiation therapy...
  54. CLINICAL TRANSLATION OF 19F MRI TO VISUALIZE CANCER IMMUNOTHERAPEUTIC CELLS
    Amy K Wesa; Fiscal Year: 2012
    ..constitute a group of patients with a unique combination of an overall poor prognosis and a 5-year overall survival rate between 20-35%, despite the presence of only minimal residual disease...
  55. New drug VS-501 for treating hyperphosphatemia in chronic kidney disease
    Jinshyun Ruth Wu-Wong; Fiscal Year: 2012
    ..Despite the various treatments available to CKD patients, the five-year survival rate is ~33%...
  56. PKD Family Kinase Function and Signaling in Lung Fibroblasts
    Hua Tang; Fiscal Year: 2012
    ..Long-term survival of IPF patients is poor, with a 5-year survival rate of only 20%...
  57. Molecular Epidemiology of non-Hodgkin Lymphoma Survival
    James R Cerhan; Fiscal Year: 2010
    ..Survival rates have only recently begun to improve, and the current 5-year survival rate is 66%...
  58. Regulation of neutrophil migration by Activated Protein C
    Minsoo Kim; Fiscal Year: 2010
    ..is important to understand its mechanisms by which rhAPC exerts its beneficial effects on organ function and survival rate in sepsis. Migration of leukocytes to infection sites is vital for pathogen clearance and thus, host survival...
  59. Regulation and function of Six1 in zebrafish muscle development and in rhabdomyos
    JENEAN O'BRIEN; Fiscal Year: 2013
    ..by applicant): Rhabdomyosarcoma (RMS) accounts for ~8% of all pediatric cancers, where the overall 5-year survival rate for children diagnosed with metastatic RMS is less than 30%...
  60. Expression-Based Multi-Gene Signatures for CRC Recurrence and Chemoselection
    Christopher Sears; Fiscal Year: 2012
    ..For example, the five-year survival rate of CRC is 90% for the over 70% of patients who do not recur (even without therapy)...
  61. Role of IL-17 in the Induction of Epithelial to Mesenchymal Transition
    Ragini Vittal; Fiscal Year: 2013
    ..for many end stage pulmonary diseases including IPF, chronic rejection (OB) sets in resulting in 50% five-year survival rate for lung transplant recipients - the worst of all solid organ transplant recipients...
  62. MONOKINE GENE EXPRESSION/REGULATION IN LUNG INJURY
    STEVEN LYNN KUNKEL; Fiscal Year: 2013
    ..an experimental model of severe sepsis (cecal ligation and puncture-CLP) which results in a long-term survival rate of approximately 60%...
  63. Targeting crosstalk between insulin and Gq signaling systems in pancreatic cancer
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ..the 4th leading cause of cancer fatalities in the United States both in men and women, with an overall 5-year survival rate of only 3-5%...
  64. Suppression of glioma invasion by a bicistronic constuct
    JASTI RAO; Fiscal Year: 2007
    Despite many therapeutic strategies for glioblastoma multiforme, the survival rate in patients with this aggressive cerebral malignancy remains poor...
  65. INTRACAVITARY HYPERTHERM & RADIATN OF ESOPHAGEAL CANCER
    C Chou; Fiscal Year: 1993
    ..protocols, current therapies involving surgery, radiation and chemotherapy have not significantly improved the survival rate in the last several decades...
  66. Using Ecolog. Momentary Assess. To Examine Pain & Smoking In Head & Neck Cancer P
    CHO YAN LAM; Fiscal Year: 2010
    Continued smoking after cancer has been diagnosed is associated with a poor treatment outcome and a low overall survival rate. However, on learning about their cancer diagnosis, many patients who smoke continue to use tobacco...
  67. Flaxseed vs. aromatase inhibitors: breast tumor characteristics and prognosis
    Susan McCann; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Although the 10 year survival rate for women with early stage breast cancer is very good, distant recurrence is still a serious concern, especially for estrogen receptor positive women...
  68. Childhood After Preterm Birth: The Preschool Years
    LISA MCELANEY; Fiscal Year: 2007
    ..DESCRIPTION (provided by applicant): In the past decade, there has been dramatic improvement in the survival rate of infants born preterm - i.e., after a pregnancy of less than 37 weeks...
  69. RANDOMIZED ADJUVANT THERAPY OF HEAD AND NECK CANCER
    Dong Shin; Fiscal Year: 2001
    ..therapy in advanced head and neck cancer after definitive local therapy has not been established, although the survival rate is low because of the high incidence of recurrence and second primary tumor development...
  70. Ethnic Differences in Survival after Childhood ALL
    Smita Bhatia; Fiscal Year: 2009
    ..by applicant): Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, with a five-year survival rate approaching 80%. We have shown highly significant differences in survival among ethnic and racial groups...
  71. The Prevalence of Barrett's Esophagus in Patients with *
    Blair Jobe; Fiscal Year: 2004
    ..The prognosis for esophageal adenocarcinoma arising from Barrett's metaplasia is poor: The overall 5-year survival rate is less than 10%...
  72. Development of UTL-5b for Rheumatoid Arthritis: Mechanism of Action
    Jiajiu Shaw; Fiscal Year: 2007
    ..UTL-5b was shown to significantly lower the elevated blood level of TNF-a and increase the survival rate in an LD100 sepsis animal model...
  73. Listeria Immunotherapy for Pancreatic and Ovarian Cancer
    Thomas Dubensky; Fiscal Year: 2006
    ..To wit: (1) pancreatic cancer patients have a 5-year survival rate of less than 5% and the 32,000 new cases per year in the U.S...
  74. Development of a Urine Test for the Early Detection of Colon Cancer
    Wei Song; Fiscal Year: 2012
    ..The 5-year survival rate for CRC is 93% if it is diagnosed at stage I but only 8% if diagnosed at stage IV [1, 2]...
  75. A Novel Device Design for Sperm Cryopreservation
    ERIK WOODS; Fiscal Year: 2009
    ..2001, 2003) and the survival rate was extremely low (<10%)...
  76. Monitoring of Oral Cancer Patients Using Novel Lab-on-a-Chip Ensembles
    John T McDevitt; Fiscal Year: 2012
    ..surgical procedures and treatment, the long-term prognosis for patients with OSCC remains poor, with a 5-year survival rate at approximately 50% which is among the lowest for all major cancers...
  77. Oral Health Disparities Among Medicaid Beneficiaries
    Sujha Subramanian; Fiscal Year: 2010
    ..In addition, significant racial disparities exist, as black males have a much lower 5-year survival rate compared with white males...
  78. UMBILICAL CORD STEM CELL CRYOPRESERVATION
    John Critser; Fiscal Year: 2000
    ..investigation is necessary to establish a stable and standard cryopreservation procedure to ensure a high survival rate of purified progenitor cells from other sources, such as umbilical cord blood...
  79. Targeted Gold Nanoparticle-Bioconjugates for Imaging Breast Cancer
    Raghuraman Kannan; Fiscal Year: 2009
    ..and therefore earlier cancer detection) with better specificity, this work has the potential to increase the survival rate from breast cancer...