fatal outcome

Summary

Summary: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.

Top Publications

  1. ncbi Fatal outcome of sleep apnoea in PWS during the initial phase of growth hormone treatment. A case report
    Urs Eiholzer
    Foundation Growth Puberty Adolescence, Zurich, Switzerland
    Horm Res 58:24-6. 2002
  2. pmc NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
    Tomohide Tsukahara
    Department of Pathology, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Diagn Pathol 7:114. 2012
  3. ncbi Fatal encephalitis due to novel paramyxovirus transmitted from horses
    J D O'Sullivan
    Department of Neurology, Royal Brisbane Hospital, Herston, Queensland, Australia
    Lancet 349:93-5. 1997
  4. ncbi Fatal coxsackievirus A16 infection
    Chung Yi Wang
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Pediatr Infect Dis J 23:275-6. 2004
  5. ncbi Fatal septicaemia from Chromobacterium violaceum: case reports and review of the literature
    A Y B Teoh
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 12:228-31. 2006
  6. pmc Hantavirus pulmonary syndrome in a Chilean patient with recent travel in Bolivia
    R Espinoza
    Clinica Alemana de Santiago, Chile
    Emerg Infect Dis 4:93-5. 1998
  7. ncbi Wasp sting: an unusual fatal outcome
    Pratish George
    Department of Internal Medicine, Christian Medical College and Hospital, Ludhiana, India
    Saudi J Kidney Dis Transpl 19:969-72. 2008
  8. ncbi Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event
    Ken H Young
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison WI 53792 2472, USA
    Am J Clin Pathol 129:157-66. 2008
  9. pmc Cardiac beriberi: morphological findings in two fatal cases
    Stefania Bello
    Department of Forensic Pathology, University of Foggia, Foggia, Italy
    Diagn Pathol 6:8. 2011
  10. ncbi Disseminated angiostrongylosis with fatal cerebral haemorrhages in two dogs in Germany: a clinical case study
    D Denk
    Institute for Veterinary Pathology, Ludwig Maximilians University Munich, Veterinarstrasse 13, 80539 Munich, Germany
    Vet Parasitol 160:100-8. 2009

Research Grants

  1. A novel telomerase expressing lung fibroblast phenotype
    Sem H Phan; Fiscal Year: 2012
  2. Tick-Mammal Interface of Human Granulocytic Anaplasmosis
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
  3. MYOFIBROBLASTS IN PULMONARY FIBROSIS
    Sem H Phan; Fiscal Year: 2012
  4. Environmental Triggers of Eating Seizures in Nodding Syndrome
    Peter S Spencer; Fiscal Year: 2013
  5. ADAM17 in pancreatic cancer and pancreatitis
    Howard C Crawford; Fiscal Year: 2013
  6. NLRP1 activation induces deletion of hematopoietic progenitor cells
    BEN ADAM CROKER; Fiscal Year: 2013
  7. Transfusion in Malaria
    Walter H Dzik; Fiscal Year: 2013
  8. Pathogenesis of Salmonella bacteremia
    Renee M Tsolis; Fiscal Year: 2013
  9. ANALYSIS OF STAPHYLOCOCCUS AUREUS HOST INTERACTIONS
    AXEL MAGNUS HOOK; Fiscal Year: 2013
  10. NIAMS: CORT
    ROBERT A LAFYATIS; Fiscal Year: 2013

Detail Information

Publications313 found, 100 shown here

  1. ncbi Fatal outcome of sleep apnoea in PWS during the initial phase of growth hormone treatment. A case report
    Urs Eiholzer
    Foundation Growth Puberty Adolescence, Zurich, Switzerland
    Horm Res 58:24-6. 2002
    ....
  2. pmc NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
    Tomohide Tsukahara
    Department of Pathology, Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Diagn Pathol 7:114. 2012
    ..We finally diagnosed this case as extranodal NK/T-cell lymphoma (nasal type). Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8050621197741854...
  3. ncbi Fatal encephalitis due to novel paramyxovirus transmitted from horses
    J D O'Sullivan
    Department of Neurology, Royal Brisbane Hospital, Herston, Queensland, Australia
    Lancet 349:93-5. 1997
    ..Fourteen horses and one human being died. A novel virus was isolated from those affected and named equine morbillivirus (EMV). We report a case of encephalitis caused by this virus...
  4. ncbi Fatal coxsackievirus A16 infection
    Chung Yi Wang
    Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
    Pediatr Infect Dis J 23:275-6. 2004
    ..A 15-month-old boy presenting with hand, foot and mouth disease died of myocarditis and intractable shock caused by coxsackievirus A16 infection. It is apparent that coxsackievirus A16 infection is not always a benign infection...
  5. ncbi Fatal septicaemia from Chromobacterium violaceum: case reports and review of the literature
    A Y B Teoh
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Hong Kong Med J 12:228-31. 2006
    ..We present three cases of human infection managed in a tertiary referral hospital in Hong Kong with a review of the literature...
  6. pmc Hantavirus pulmonary syndrome in a Chilean patient with recent travel in Bolivia
    R Espinoza
    Clinica Alemana de Santiago, Chile
    Emerg Infect Dis 4:93-5. 1998
    ....
  7. ncbi Wasp sting: an unusual fatal outcome
    Pratish George
    Department of Internal Medicine, Christian Medical College and Hospital, Ludhiana, India
    Saudi J Kidney Dis Transpl 19:969-72. 2008
    ..A rare com-plication of a patient following multiple wasp stings with disseminated intravascular coagulation, acute renal failure and thrombotic microangiopathy is presented...
  8. ncbi Transformation of follicular lymphoma to precursor B-cell lymphoblastic lymphoma with c-myc gene rearrangement as a critical event
    Ken H Young
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison WI 53792 2472, USA
    Am J Clin Pathol 129:157-66. 2008
    ..The c-myc translocation is also reported in similar cases in the literature and likely is crucial in the pathogenesis of the PBC-LBL...
  9. pmc Cardiac beriberi: morphological findings in two fatal cases
    Stefania Bello
    Department of Forensic Pathology, University of Foggia, Foggia, Italy
    Diagn Pathol 6:8. 2011
    ..Morphologically, myocardial necrosis and colliquative myocytolysis are the histologic hallmarks of this acute, rare clinical entity. An increase in apoptotic myocytes was demonstrated probably sustaining the cardiogenic shock...
  10. ncbi Disseminated angiostrongylosis with fatal cerebral haemorrhages in two dogs in Germany: a clinical case study
    D Denk
    Institute for Veterinary Pathology, Ludwig Maximilians University Munich, Veterinarstrasse 13, 80539 Munich, Germany
    Vet Parasitol 160:100-8. 2009
    ..There is currently still a lack of studies investigating the occurrence of angiostrongylosis in dogs and intermediate hosts in Germany which would be necessary to survey the endemic realities of this disease...
  11. ncbi Small cell ovarian carcinoma: a rare, aggressive tumor masquerading as constipation in a teenager with a fatal outcome
    Jesse Barondeau
    Department of Pediatrics, Madigan Army Medical Center, Tacoma, WA, USA
    J Pediatr Hematol Oncol 32:e139-41. 2010
    ..She ultimately passed away 13 months after the diagnosis, demonstrating the poor prognosis and rapid spread of this rare disease...
  12. ncbi High levels of adenovirus DNA in serum correlate with fatal outcome of adenovirus infection in children after allogeneic stem-cell transplantation
    Marco W Schilham
    Department of Pediatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Clin Infect Dis 35:526-32. 2002
    ..Quantification of adenoviral DNA in serum may prove to be a valuable tool to diagnose and monitor AdV infection and disease in immunocompromised children...
  13. ncbi Fatal outcome of a disseminated dual infection with drug-resistant Mycoplasma hominis and Ureaplasma parvum originating from a septic arthritis in an immunocompromised patient
    Colin R Mackenzie
    Institute of Medical Microbiology and Hospital Hygiene, University Hospital, Heinrich Heine University, Universitätsstraße 1, Dusseldorf, Germany
    Int J Infect Dis 14:e307-9. 2010
    ..This may be of increasing importance as illustrated in the case below...
  14. pmc Tubulinosema sp. microsporidian myositis in immunosuppressed patient
    Maria M Choudhary
    Cleveland Clinic Foundation, Department of Internal Medicine, 9500 Euclid Foundation, NA10, Cleveland, OH 44195, USA
    Emerg Infect Dis 17:1727-30. 2011
    ..We report an infection by Tubulinosema sp. in an immunosuppressed patient...
  15. ncbi Prenatal diagnosis of idiopathic infantile arterial calcification with hydrops fetalis
    F K Nasrallah
    Department of Obstetrics and Gynecology, King Abdulaziz Medical City, Jeddah, Saudi Arabia
    Ultrasound Obstet Gynecol 34:601-4. 2009
    ..Detection of echogenic intracardiac focus could be an early marker in patients with a family history of the disease...
  16. ncbi Fatal outcome due to deficiency of subunit 6 of the conserved oligomeric Golgi complex leading to a new type of congenital disorders of glycosylation
    Jürgen Lübbehusen
    Center for Child and Adolescent Medicine, Center for Metabolic Diseases Heidelberg, Department I, Heidelberg, Germany
    Hum Mol Genet 19:3623-33. 2010
    ..characterized by vitamin K deficiency, vomiting, intractable focal seizures, intracranial bleedings and fatal outcome in early infancy...
  17. ncbi Malignant transformation of meningeal melanocytoma: a case report
    Yoichi Uozumi
    Department of Neurosurgery, Fukuoka Tokushukai Hospital, Sukukita 4 5, Kasuga, Fukuoka 816 0864, Japan
    Brain Tumor Pathol 20:21-5. 2003
    ..After six months, he died from cerebrospinal fluid dissemination of this tumor. To our knowledge, this is the first report of malignant transformation of an intracranial meningeal melanocytoma...
  18. pmc Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report
    Gabriella Aquino
    Pathology Unit, National Cancer Institute Fondazione Giovanni Pascale, Via Mariano Semmola, 80131 Napoli, Italy
    Diagn Pathol 7:79. 2012
    ..Several pitfalls could lead to misinterpretation of diagnosis, therefore, we underlined the need to integrate the classical histology and immunohistochemistry with molecular tests as clonality or fluorescence in situ hybridization...
  19. ncbi Rhabdoid carcinoma of the colon: a distinct entity with a very aggressive behavior: a case report associated with a polyposis coli and review of the literature
    Andrea Remo
    Department of Pathology, Mater Salutis Hospital, ULSS 21 Legnago, Verona, Italy
    Int J Surg Pathol 20:185-90. 2012
    ..It is argued that RCT could be a very aggressive entity of colon, which could benefit from new biological colonic treatments...
  20. pmc 5q11.2 deletion in a patient with tracheal agenesis
    Elisabeth M de Jong
    Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Eur J Hum Genet 18:1265-8. 2010
    ..No common deletions or duplications are found in our cohort, suggesting that TA is a genetically heterogeneous disorder...
  21. ncbi Post-intubation tracheal injury: report of three cases and literature review
    Carlos Remolina Medina
    Pavilhão Pereira Filho, Complexo Hospitalar Santa Casa, Porto Alegre, RS, Brasil
    J Bras Pneumol 35:809-13. 2009
    ..We report the cases of three patients presenting tracheal laceration due to traumatic orotracheal intubation, two submitted to surgical treatment and one submitted to conservative treatment...
  22. ncbi Infection of humans and horses by a newly described morbillivirus
    L A Selvey
    Communicable Diseases Branch, Queensland Health, Brisbane
    Med J Aust 162:642-5. 1995
    ..To describe the clinical and epidemiological features of an outbreak of a viral infection affecting humans and horses...
  23. ncbi Fluctuating liver functions in siblings with MPV17 mutations and possible improvement associated with dietary and pharmaceutical treatments targeting respiratory chain complex II
    Shunsaku Kaji
    Department of Pediatrics, Tsuyama Central Hospital, Tsuyama shi, Okayama 708 0841, Japan
    Mol Genet Metab 97:292-6. 2009
    ..To describe the clinical and biological findings of two Japanese siblings with novel MPV17 gene mutations (c.451insC/c.509C > T) manifesting hepatic mitochondrial DNA depletion syndrome...
  24. ncbi Malignant nerve-sheath tumor with divergent and glandular differentiation in a dog: a case report
    A K Patnaik
    Department of Pathology, The Animal Medical Center, New York, NY 10021, USA
    Vet Pathol 39:406-10. 2002
    ..The tumor was located in the peripheral nerve roots at the first and second lumbar vertebrae. The dog survived for 161 days after resection of the tumor...
  25. ncbi Thyroid carcinosarcoma in a dog
    B Grubor
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, IA 50011 1250, USA
    Vet Pathol 42:84-7. 2005
    ..This is the fifth canine case of thyroid carcinosarcoma to be documented, but the first one to be confirmed by specific cell markers. It is an extremely rare neoplasm that also occurs in people...
  26. pmc Ostial plication: a rarely reported cause of sudden death
    Fabio De-Giorgio
    Institute of Legal Medicine, Catholic University, School of Medicine, Rome, Italy
    Diagn Pathol 5:15. 2010
    ..We believe that this case will be useful to autopsy pathologists in detecting this infrequent anomaly, thus providing a more accurate estimation of its incidence...
  27. pmc NK/T cell lymphoma of the lung: a case report and review of literature
    P Laohaburanakit
    Division of Pulmonary and Critical Care Medicine, University of California, Davis, 4150 V Street Suite 3400, Sacramento, CA 95817, USA
    Thorax 61:267-70. 2006
    ..Post mortem examination revealed primary pulmonary T cell lymphoma with natural killer (NK) cell features. We present what may be the first case of primary NK/T cell pulmonary lymphoma and review the literature on the subject...
  28. ncbi Age as a risk factor for severe manifestations and fatal outcome of falciparum malaria in European patients: observations from TropNetEurop and SIMPID Surveillance Data
    N Mühlberger
    Department of Infectious Diseases and Tropical Medicine, University of Munich, Munich, Germany
    Clin Infect Dis 36:990-5. 2003
    ..Our study provides evidence that falciparum malaria is more serious in older patients and demonstrates that clinical surveillance networks are capable of providing quality data for investigation of rare events or diseases...
  29. ncbi Chromosome 17 abnormalities in pediatric neuroblastic tumor with abundant neuropil and true rosettes
    Christine Fuller
    Department of Pathology, St Jude Children s, Research Hospital, Memphis, TN, USA
    Am J Clin Pathol 126:277-83. 2006
    ..No deletions of INI1 or amplifications of MYC or MYCN were detected. This report adds 2 cases to our experience of PNTANTR and is the first to demonstrate isochromosome 17q, a molecular alteration typical of medulloblastomas...
  30. ncbi Embryonal tumor with abundant neuropil and true rosettes (ETANTR): a new distinctive variety of pediatric PNET: a case-based update
    Belen Ferri Niguez
    Service of Pathology, Virgen de la Arrixaca University Hospital, El Palmar, 30120 Murcia, Spain
    Childs Nerv Syst 26:1003-8. 2010
    ..A distinctive subtype of PNET called "embryonal tumor with abundant neuropil and true rosettes" (ETANTR) was reported in 2000...
  31. ncbi Squamous cell carcinoma arising in recurrent respiratory papillomatosis with pulmonary involvement: emerging common pattern of clinical features and human papillomavirus serotype association
    J R Cook
    Lauren V Ackerman Laboratory of Surgical Pathology, Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    Mod Pathol 13:914-8. 2000
    ....
  32. ncbi Hepatocerebral form of mitochondrial DNA depletion syndrome: novel MPV17 mutations
    Antonella Spinazzola
    Unit of Molecular Neurogenetics, Pierfranco and Luisa Mariani Center, Study of Children s Mitochondrial Disorders, C Besta Neurological Institute Foundation, Milano, Italy
    Arch Neurol 65:1108-13. 2008
    ..Autosomal recessive mutations in MPV17 (OMIM *137960) have been identified in the hepatocerebral form of mitochondrial DNA depletion syndrome (MDS)...
  33. ncbi Iodine-131-metaiodobenzylguanidine therapy with reduced-intensity allogeneic stem cell transplantation in recurrent neuroblastoma
    Hiroka Takahashi
    Department of Pediatrics, St Luke s International Hospital, Chuo Ku, Tokyo, Japan
    Pediatr Blood Cancer 50:676-8. 2008
    ..Neither acute nor chronic graft-versus-host disease (GVHD) was observed. The patient remained in remission for 3 months after RIST until the second relapse. MIBG therapy combined with RIST warrants further trials...
  34. ncbi Recurrent inverted papilloma with intracranial and temporal fossa involvement: A case report and review of the literature
    C M Acevedo-Henao
    Department of Radiotherapy, Morvan Hospital, CHU de Brest, Brest University, France
    Cancer Radiother 14:202-5. 2010
    ..Intracranial and temporal fossa involvements are rare and the treatment depends of the symptoms and the severity of the disease...
  35. ncbi Idiopathic infantile arterial calcification: prenatal diagnosis and postnatal presentation
    A Cansu
    Department of Radiology, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey
    Clin Exp Obstet Gynecol 37:73-5. 2010
    ..During routine obstetric ultrasonography, the combination of polyhydramniosis and intrauterine growth restriction may necessitate examination of the major vessels for presumptive a diagnosis of IIAC...
  36. ncbi Tracheal agenesis with unique anatomy
    Nia Fraser
    Department of Paediatric Surgery, Nottingham Hospitals NHS Trust, Queens Medical Centre, NG7 2UH Nottingham, UK
    J Pediatr Surg 40:e7-10. 2005
    ..The possibility of surgical correction rests on early diagnosis, anatomy, birth weight, and associated anomalies. Early recognition is mandatory, but in our case, the low birth weight precluded consideration for reconstructive surgery...
  37. ncbi Influenza A virus-associated encephalopathy with haemophagocytic syndrome
    Toru Watanabe
    Department of Paediatrics, Niigata City General Hospital, 2 6 1 Shichikuyama, 950 8739 Niigata, Japan
    Eur J Pediatr 162:799-800. 2003
  38. ncbi Chromobacterium violaceum infection in children: a case of fatal septicemia with nasopharyngeal abscess and literature review
    Pei Lan Shao
    Department of Pediatrics, Taipei Hospital, Taiwan
    Pediatr Infect Dis J 21:707-9. 2002
    ..He received intravenous cefazolin therapy for 2 days, followed by penicillin, oxacillin and netilmicin. However, no improvement was noted, and he died on the fifth days of illness...
  39. ncbi Fatal familial lung disease caused by ABCA3 deficiency without identified ABCA3 mutations
    W Adam Gower
    Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 2533, USA
    J Pediatr 157:62-8. 2010
    ..To test the hypothesis that some functionally significant variants in the gene encoding member A3 of the ATP Binding Cassette family (ABCA3) are not detected using exon-based sequencing approaches...
  40. ncbi Neurolymphomatosis associated with muscle and cerebral involvement caused by natural killer cell lymphoma: a case report and review of literature
    Z Odabasi
    Department of Neurology, The University of Alabama at Birmingham, The Veterans Affairs Medical Center, 35294, USA
    J Peripher Nerv Syst 6:197-203. 2001
    ..Bone marrow biopsy showed neoplastic infiltrates. The patient died of multiple organ failure prior to initiation of chemotherapy...
  41. ncbi Pulmonary tumor thrombotic microangiopathy from metastatic gallbladder carcinoma: an unusual cause of severe pulmonary hypertension
    Ashok K Malani
    Department of Oncology, Heartland Regional Medical Center, St Joseph, MO 64503, USA
    Dig Dis Sci 52:555-7. 2007
    ..To the best of our knowledge, this is likely the second reported case of PTTM from metastatic gallbladder carcinoma...
  42. ncbi Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach
    Naomi Sakashita
    Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan
    Pathol Int 57:383-7. 2007
    ..These findings suggest that local expression of VEGF, TF, and 5-HT(2A) may be linked to the pathogenesis of this unusual pulmonary complication...
  43. ncbi Suspected metastatic coccygeal chordoma in a ferret (Mustela putorius furo)
    John S Munday
    Athens Diagnostic Laboratory and Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    J Vet Diagn Invest 16:454-8. 2004
    ..Observations from this case suggest that chordomas in ferrets may have metastatic potential and so should be removed promptly...
  44. pmc Fatal myositis due to the microsporidian Brachiola algerae, a mosquito pathogen
    Christina M Coyle
    Department of Medicine, Jacobi Medical Center, Bronx, NY 10461, USA
    N Engl J Med 351:42-7. 2004
  45. ncbi Fatal outcome of nevirapine-associated toxic epidermal necrolysis
    K Leng
    Department of Dermatology, University of Heidelberg, Universitäts Hautklinik, Vosstrasse 2, Heidelberg, Germany
    Int J STD AIDS 19:642-3. 2008
    ..We report a case of nevirapine-associated toxic epidermal necrolysis resulting in death in an HIV-infected man...
  46. ncbi Pyridoxine-responsive seizures as the first symptom of infantile hypophosphatasia caused by two novel missense mutations (c.677T>C, p.M226T; c.1112C>T, p.T371I) of the tissue-nonspecific alkaline phosphatase gene
    Sara Baumgartner-Sigl
    Department of Pediatrics, Medical University Innsbruck, Austria
    Bone 40:1655-61. 2007
    ..We recommend that assessment of any neonate with PRS should include measurement of serum ALP activity...
  47. ncbi Osteoclast-like giant cell tumor of the pancreas associated with mucus-secreting adenocarcinoma. Case report and discussion of the histogenesis
    Gisele A Nai
    Department of Pathology, College of Medicine, Universidade do Oeste Paulista, Presidente Prudente, Sao Paulo, Brazil
    Pancreatology 5:279-84. 2005
    ..Some tumors also contain areas of ductal adenocarcinoma. Conflicting opinions exist regarding the tumor origin, whether it is mesenchymal or epithelial, neoplastic or reactive...
  48. pmc Neuroinvasion by Mycoplasma pneumoniae in acute disseminated encephalomyelitis
    Bernhard Stamm
    Kantonsspital Aarau, Aarau, Switzerland
    Emerg Infect Dis 14:641-3. 2008
    ..M. pneumoniae antigens were demonstrated by immunohistochemical analysis of brain tissue, indicating neuroinvasion as an additional pathogenetic mechanism in central neurologic complications of M. pneumoniae infection...
  49. ncbi Complete genetic characterization of a Brazilian dengue virus type 3 strain isolated from a fatal outcome
    Marize Pereira Miagostovich
    Departamento de Virologia, Instituto Oswaldo Cruz FIOCRUZ, Rio de Janeiro, RJ, 21040 900, Brasil
    Mem Inst Oswaldo Cruz 101:307-13. 2006
    ..and the deduced amino acid sequences of Brazilian dengue virus type 3 (DENV-3) from a dengue case with fatal outcome, which occurred during an epidemic in the state of Rio de Janeiro, Brazil, in 2002...
  50. ncbi Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma
    Menno D de Jong
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    N Engl J Med 352:686-91. 2005
    ..In both siblings, the clinical diagnosis was acute encephalitis. Neither patient had respiratory symptoms at presentation. These cases suggest that the spectrum of influenza H5N1 is wider than previously thought...
  51. ncbi Probable person-to-person transmission of avian influenza A (H5N1)
    Kumnuan Ungchusak
    Bureau of Epidemiology, Department of Disease Control, Thai Ministry of Public Health, Nonthaburi, Thailand
    N Engl J Med 352:333-40. 2005
    ..No evidence of efficient person-to-person transmission has yet been reported. We investigated possible person-to-person transmission in a family cluster of the disease in Thailand...
  52. pmc Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion
    Elsebet Ostergaard
    Department of Clinical Genetics, National University Hospital Rigshospitalet, Copenhagen, Denmark
    Am J Hum Genet 81:383-7. 2007
    ..The mtDNA depletion is likely explained by decreased mitochondrial nucleoside diphosphate kinase (NDPK) activity resulting from the inability of NDPK to form a complex with SUCL...
  53. pmc Fatal outcome of a hypersensitivity reaction to paclitaxel: a critical review of premedication regimens
    J S Kloover
    Department of Pulmonology, Erasmus MC, Postbus 2040, 3000 CA Rotterdam, The Netherlands
    Br J Cancer 90:304-5. 2004
    ..In this case report, we describe the fatal outcome of an HSR in a patient receiving paclitaxel despite short-course premedication...
  54. ncbi Metastatic malignant melanoma of the gastrointestinal tract
    Kelly V Liang
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Mayo Clin Proc 81:511-6. 2006
    ..Management may include surgical resection, chemotherapy, immunotherapy, observation, or enrollment in clinical trials. Prognosis is poor, with a median survival of 4 to 6 months...
  55. ncbi Glycosylphosphatidylinositol-induced cardiac myocyte death might contribute to the fatal outcome of Plasmodium falciparum malaria
    Kathrin Wennicke
    Department of Internal Medicine Cardiology, Philipps University of Marburg, University Hospital, Baldingerstrasse 1, 35043 Marburg Lahn, Germany
    Apoptosis 13:857-66. 2008
    ..Previous studies demonstrated cardiac involvement in patients suffering from severe malaria due to P. falciparum. Therefore, we tested the hypothesis that GPI induces apoptosis in cardiomyocytes...
  56. ncbi Ectopic location of adult worms and first-stage larvae of Angiostrongylus vasorum in an infected dog
    S D Oliveira-Junior
    Laboratório de Helmintologia Veterinária, Departamento de Parasitologia, Universidade Federal de Minas Gerais, ICB, Caixa Postal 486, CEP 31270 901, Minas Gerias, Brazil
    Vet Parasitol 121:293-6. 2004
    ..A total of 587 A. vasorum first-stage larvae were recovered from different organs and tissues after concentration using Baermann apparatus...
  57. pmc Vanishing bile duct syndrome in a Hodgkin's lymphoma patient with fatal outcome despite lymphoma remission
    Aamer Aleem
    Department of Medicine, Division of Hematology Oncology, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
    Saudi J Gastroenterol 19:286-9. 2013
    ..HL-associated VBDS carries a high mortality but lymphoma remission can be achieved in some patients. Therefore, liver transplantation should be considered early in these patients. ..
  58. ncbi Possible role of a radiation-induced p53 mutation in a Nelson's syndrome patient with a fatal outcome
    Emilia Modolo Pinto
    Laboratorio de Hormonios e Genetica Molecular LIM 42, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    Pituitary 14:400-4. 2011
    ..These data demonstrate a possible association between the P53 protein loss of function induced by radiotherapy and the aggressive course of the disease in this patient...
  59. ncbi Severe interstitial pneumonitis associated with docetaxel administration
    William L Read
    Department of Medicine, Division of Medical Oncology at Washington University, St Louis, Missouri, USA
    Cancer 94:847-53. 2002
    ..Interstitial pneumonitis has not been reported as a toxicity of docetaxel. The authors report the presentation and natural history of four patients who developed a severe interstitial pneumonitis after receiving docetaxel...
  60. ncbi Complete deficiency of mitochondrial trifunctional protein due to a novel mutation within the beta-subunit of the mitochondrial trifunctional protein gene leads to failure of long-chain fatty acid beta-oxidation with fatal outcome
    Karl Otfried Schwab
    Department of Paediatrics, Albert Ludwigs University Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
    Eur J Pediatr 162:90-5. 2003
    ..In fibroblasts and liver, activities of all three catalytic units of MTP were markedly decreased, further confirming the diagnosis of MTP deficiency...
  61. pmc Disseminated Nocardia farcinica: literature review and fatal outcome in an immunocompetent patient
    Jonathan M Budzik
    Department of Pathology, Pritzker School of Medicine, Chicago, Illinois, USA
    Surg Infect (Larchmt) 13:163-70. 2012
    ..Nocardia farcinica is a gram-positive, partially acid-fast, methenamine silver-positive aerobic actinomycete. Nocardia spp. are opportunistic pathogens, and N. farcinica is the least common species of clinical importance...
  62. ncbi A fatal outcome after unintentional overdosing of rivastigmine patches
    Henrik Lövborg
    Department of Drug Research Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, Department of Clinical Pharmacology, County Council of Ostergotland, S 581 85 Linkoping, Sweden
    Curr Drug Saf 7:30-2. 2012
    ..Rivastigmine is an acetylcholine esterase inhibitor used in the treatment of dementia. Patches with rivastigmine for transdermal delivery have been used to increase compliance and to reduce side effects...
  63. ncbi Primary, pure, large-cell neuroendocrine carcinoma of the urinary bladder
    S Hailemariam
    University of Zurich, Switzerland
    Mod Pathol 11:1016-20. 1998
    ....
  64. ncbi Esophagus cancer and IgA deficiency in a patient with Dubowitz syndrome: a case report
    Ibrahim Halil Turkbeyler
    Gaziantep University Faculty of Medicine, Department of Internal Medicine, Gaziantep, Turkey
    Tokai J Exp Clin Med 36:29-30. 2011
    ..However, Esophagus cancer has not been reported among the malignant tumors. Herein, we reported a patient with Dubowitz syndrome, IgA deficiency and Esophagus cancer...
  65. ncbi Thyroid involvement in disseminated zygomycosis by Cunninghamella bertholletiae: 2 cases and literature review
    Emilio Mayayo
    Sección de Patología Infecciosa, Servicio de Patologia, Hospital Universitario Juan XX, Tarragona, Spain
    Int J Surg Pathol 19:75-9. 2011
    ..We describe two cases of thyroiditis due to Cunninghamella bertholletiae diagnosed though a necropsy study and the only five previous cases of thyroid zygomycosis reported in the literature are revised...
  66. ncbi [Hypersensitivity syndrome during therapy with allopurinol in asymptomatic hyperuricemia with a fatal outcome]
    B Hammer
    Medizinische Klinik und Poliklinik, Innere Medizin III Kardiologie Angiologie, Homburg Saar
    Dtsch Med Wochenschr 126:1331-4. 2001
    ..A 86-year-old woman with chronic renal failure was treated with allopurinol for asymptomatic hyperuricemia. After one week she developed quickly progressive exanthema, bullous eruptions, epidermolysis, fever of 39.1; C and dyspnoea at rest...
  67. ncbi Fatal reactivation of hepatitis B post-chemotherapy for lymphoma in a hepatitis B surface antigen-negative, hepatitis B core antibody-positive patient: potential implications for future prophylaxis recommendations
    Joanna K Law
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Leuk Lymphoma 46:1085-9. 2005
    ..Our experience indicates that patients who are negative for HBsAg but positive for anti-HBc are still at risk for reactivation of latent hepatitis B during and after chemotherapy and may be considered for prophylaxis...
  68. ncbi Fatal outcome after heart transplantation caused by Aspergillus lentulus
    A Zbinden
    Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland
    Transpl Infect Dis 14:E60-3. 2012
    ..This is the first report, to our knowledge, of a proven pulmonary invasive fungal infection caused by A. lentulus after heart transplantation...
  69. ncbi Multiple ischemic strokes after transcatheter arterial chemoembolization for hepatocellular carcinoma with a radiographic and pathological correlate
    Victor Zach
    Department of Neurology, The Mount Sinai School of Medicine, New York, New York, USA
    J Stroke Cerebrovasc Dis 21:217-24. 2012
    ..Transcatheter arterial chemoembolization (TACE) is a widely used form of therapy in advanced hepatocellular carcinoma. We report the first pathological data from an autopsy case of multiple cerebral emboli occurring during TACE...
  70. ncbi Leiomyosarcoma of the inferior vena cava extending into the right atrium. A rare differential diagnosis of a right atrial tumor with fatal outcome
    U Lotze
    Department of Internal Medicine, DRK Hospital Sondershausen, Hospitalstr 2, 99706, Sondershausen, Germany
    Herz 37:573-8. 2012
    ..A few hours following the procedure the patient died due to a further episode of irreversible intra-abdominal hemorrhage...
  71. ncbi Death after liposuction: case report and review of the literature
    Claudio Terranova
    Section of Legal Medicine and Forensic Pathology, Department of Environmental Medicine and Public Health, University of Padova, Via Falloppio 50, 35121 Padova, Italy
    Med Sci Law 50:161-3. 2010
    ..The medico-legal interest of the case lies in the singular anatomo-pathological cause of death, discussed in relation to the hypothesis of professional responsibility after surgical intervention for liposuction...
  72. ncbi Meningeal melanocytoma: an aggressive course for a benign tumor
    Ali Bydon
    Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI 48202, USA
    J Neurooncol 64:259-63. 2003
    ..In this report, we present an unusual case of spinal meningeal melanocytoma with diffuse spread throughout the craniospinal axis that proved to be fatal...
  73. ncbi Carcinosarcoma of the vulva: a case report
    Vera Loizzi
    Department of Obstetrics and Gynecology, University of Bari, Bari, Italy
    J Obstet Gynaecol Res 36:705-8. 2010
    ....
  74. ncbi The fatal outcome of an individual with anorexia nervosa and Sheehan's syndrome as a result of acute enterocolitis: a case report
    Werner Kopp
    University Hospital Charite, Campus Benjamin Franklin, Berlin, Germany
    Int J Eat Disord 43:93-6. 2010
    ..To illustrate the close association between a disturbed psychosocial up-bringing, frequent physical illness, and medical interventions...
  75. ncbi Malignant glomus tumor of the stomach with multiorgan metastases: report of a case
    Sung Eun Song
    Department of Radiology, Korea University Guro Hospital, Korea University College of Medicine, 80 Guro dong, Guro Gu, Seoul, 152 703, Republic of Korea
    Surg Today 40:662-7. 2010
    ..The clinical presentation and imaging results are discussed, and the literature on malignant glomus tumors is reviewed...
  76. ncbi Severe thrombocytopenia and haemolytic anaemia associated with ciprofloxacin: a case report with fatal outcome
    Marco Tuccori
    Tuscan Regional Centre for Pharmacovigilance, Florence, Italy
    Platelets 19:384-7. 2008
    Haematological adverse reactions associated with fatal outcome are rare during treatment with ciprofloxacin...
  77. ncbi Ischemic myocardial injuries after cardiac malformation repair in infants may be associated with oxidative stress mechanisms
    Marcela S Oliveira
    Department of Pathology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, SP, Brazil
    Cardiovasc Pathol 20:e43-52. 2011
    ..This study investigated the pathology-related differences in 29 infants with congenital heart disease that led to death. The infants were treated at the University Hospital of Ribeirão Preto, Brazil...
  78. ncbi [New influenza virus (H1N1) related pneumonia with fatal outcome]
    László Bidiga
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Pathologiai Intézet, Debrecen
    Orv Hetil 151:576-9. 2010
    ..In order to obtain correct statistical data on virus related mortality, only unambiguous cases with clear virus associated morphological changes should be considered...
  79. ncbi Prostatic stromal sarcoma with rhabdoid features
    Joo Young Kim
    Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 138 736 Seoul, Korea
    Ann Diagn Pathol 14:453-6. 2010
    ..To the best of our knowledge, this is the first case of PSS with rhabdoid features. The tumor showed an aggressive clinical behavior with a short-term survival (7 months after diagnosis)...
  80. ncbi Ovarian malignant melanoma: a clinicopathologic study of 5 cases
    Shir Hwa Ueng
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Int J Surg Pathol 18:184-92. 2010
    ..Familiarity with the wide range of morphologic patterns presented here will raise awareness and facilitate detection of future cases of ovarian melanoma...
  81. ncbi Osteopontin expression in pulmonary tumor thrombotic microangiopathy caused by gastric carcinoma
    Fumiyuki Takahashi
    Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo, Japan
    Pathol Int 59:752-6. 2009
    ..To the best of the authors' knowledge this is the first report to demonstrate the possible involvement of OPN in PTTM. It is postulated that OPN is one of the candidate molecules for the development of PTTM...
  82. ncbi Bacille Calmette-Guérin infection and disease with fatal outcome associated with a point mutation in the interleukin-12/interleukin-23 receptor beta-1 chain in two Mexican families
    Sigifredo Pedraza-Sánchez
    Department of Biochemistry, National Institute for Medical Sciences and Nutrition Salvador Zubiran, Vasco de Quiroga 15, Delegacion Tlalpan, Mexico
    Int J Infect Dis 14:e256-60. 2010
    ..are the first cases in Mexico of patients with BCG disease traced to a mutation in the IL12RB1 gene, with a fatal outcome. Doctors must be alert to the adverse reactions to BCG vaccination and to persistent Mycobacterium infections, ..
  83. ncbi Colonic adenocarcinoma with metastasis to the gingiva
    Carlos Alvarez-Alvarez
    Servicio de Anatomia Patologica, Hospital POVISA, Vigo, Pontevedra, Spain
    Med Oral Patol Oral Cir Bucal 11:E85-7. 2006
    ..The intraoral spread of a disseminated neoplasm is generally a sign of bad prognosis, although a longer survival can be expected if a radical surgical treatment of a solitary metastasis is carried out...
  84. ncbi Solitary cystic cerebral metastasis from transitional cell carcinoma of the bladder
    Andreas Zigouris
    Department of Neurosurgery, University Hospital of Ioannina, Greece
    Acta Neurol Belg 109:322-5. 2009
    ..Although intracranial metastases from TCC of urinary bladder have a low incidence, in follow-up examinations any alterations in neurological status in these patients should be thoroughly evaluated...
  85. ncbi A fulminant case of acute respiratory distress syndrome associated with Mycoplasma pneumoniae infection
    Rama Chaudhry
    Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110 029, India
    Indian J Pathol Microbiol 53:555-7. 2010
    ..We suggest that M. pneumoniae infections should be included in the differential diagnosis of pathogens causing ARDS, establishing an early diagnosis may have important therapeutic implications...
  86. pmc Inflammatory myofibroblastic tumour of paranasal sinuses with fatal outcome: reactive lesion or tumour?
    N Gale
    Institute of Pathology, Medical Faculty, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia
    J Clin Pathol 56:715-7. 2003
    ..This report describes a case of IMT of the paranasal sinuses with a fatal outcome. A 22 year old woman was admitted to hospital as a result of epistaxis...
  87. ncbi Extramammary Paget's disease of the groin with underlying carcinoma and fatal outcome
    J C Pascual
    Department of Dermatology, General University Hospital of Elche, Spain
    Clin Exp Dermatol 33:595-8. 2008
    ....
  88. ncbi Metastasis to the percutaneous endoscopic gastrostomy site in the patient with head and neck cancer: a case report and review of the literature
    Domenick Coletti
    Department of Oral and Maxillofacial Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Oral Maxillofac Surg 64:1149-57. 2006
  89. ncbi Use of cyclosporine to treat granulomatous meningoencephalitis in three dogs
    Filippo P Adamo
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    J Am Vet Med Assoc 225:1211-6, 1196. 2004
    ..7 mg/lb) every 12 hours. Adverse effects associated with cyclosporine administration included transient lymphopenia, excessive shedding, and focal symmetric hair discoloration...
  90. ncbi Acute subepicardial infarction associated with severe septic shock--insight in myocardial perfusion
    Annette M May
    Department of Pathology, University of Freiburg, Breisacher Strasse 115a, D 79106 Freiburg i Br, Germany
    Pathol Res Pract 206:401-4. 2010
    ..Microscopically, we observed fibrin microemboli in the subepicardial microvessels. The existence of an isolated subepicardial myocardial infarct challenges our understanding of myocardial perfusion...
  91. ncbi EBV-associated B- and T-cell posttransplant lymphoproliferative disorders following primary EBV infection in a kidney transplant recipient
    C Cameron Yin
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 123:222-8. 2005
    ..To our knowledge, only 4 cases of both B-cell and T-cell PTLDs have been reported. Only 2 cases have been proven to be monoclonal and EBV-associated, as in this case, the first following kidney transplantation...
  92. ncbi Cerebral fat embolism syndrome causing brain death after long-bone fractures and acetazolamide therapy
    Criona M Walshe
    Alfred Hospital, Melbourne, Vic, Australia
    Crit Care Resusc 9:184-6. 2007
    ..Acetazolamide should be used with caution, as sudden restoration of normocapnia during compensated metabolic acidosis in patients with raised intracranial pressure may precipitate coning...
  93. ncbi Fatal acute fibrinous and organizing pneumonia in an infant: The histopathologic variability of acute respiratory distress syndrome
    Domenic R Cincotta
    Paediatric and Neonatal Intensive Care Unit, Great Ormond Street Hospital for Children, NHS Trust, London, UK
    Pediatr Crit Care Med 8:378-82. 2007
    ..The objective of this study was to determine whether similar appearances can be seen in infant ARDS...
  94. ncbi Malignant schwannoma in an American buffalo (Bison bison bison)
    H S Cho
    Department of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Vet Med A Physiol Pathol Clin Med 53:432-4. 2006
    ..Based on the above findings, this case was diagnosed as a malignant schwannoma. To the best of our knowledge, this is the first report of a schwannoma in an American buffalo (B. b. bison)...
  95. ncbi Clinical and ultrasonographic findings in five cows with a ruptured urachal remnant
    U Braun
    Department of Farm Animals, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Vet Rec 159:780-2. 2006
  96. ncbi Chromobacterium violaceum infection: A rare but frequently fatal disease
    A Chattopadhyay
    Department of Paediatric Surgery, Kasturba Medical College, Manipal 5765119, Karnataka, India
    J Pediatr Surg 37:108-10. 2002
    ....
  97. pmc Tetralogy of Fallot in a 2-year-old Holstein heifer
    Shawn L B McKenna
    Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, 550 University Drive, Charlottetown, Prince Edward Island C1A 4P3
    Can Vet J 44:312-3. 2003
    ..Survival past the age of 2 was unexpected. The concurrent endocarditis of the pulmonic valve is discussed...
  98. ncbi An inflammatory myofibroblastic tumor in liver with ALK and RANBP2 gene rearrangement: combination of distinct morphologic, immunohistochemical, and genetic features
    Sung Ting Chen
    Department of Pathology, National Taiwan University Hospital, Medical College, National Taiwan University, Taipei 10001, Taiwan
    Hum Pathol 39:1854-8. 2008
    ..The diagnostic difficulty and other prognostic factors of inflammatory myofibroblastic tumor are also discussed...
  99. ncbi Large bowel ischemia following laparoscopic inguinal hernioplasty
    D Bandyopadhyay
    Department of Surgery, Airedale General Hospital, Skipton Road, West Yorkshire, BD20 6TD, United Kingdom
    Surg Endosc 17:520-1. 2003
    ..To our knowledge, this is the first reported case of large bowel ischemia following pneumoperitoneum. We conclude that the presence of an aortic aneurysm is an added risk factor in laparoscopy...
  100. ncbi A massive intraventricular thrombosis by disseminated mucormycosis in a patient with myelodysplastic syndrome during deferoxamine therapy
    Naoshi Kubota
    First Department of Internal Medicine, Second Department of Pathology, Tokyo Medical University
    Haematologica 88:EIM13. 2003
  101. ncbi Combined hepatocellular-cholangiocarcinoma in a lesser flamingo (Phoenicopterus minor)
    A J Van Wettere
    Center for Comparative Medicine and Translational Research, Raleigh, NC 27606, USA
    Avian Pathol 39:275-8. 2010
    ..CHCC is a rare neoplasm in mammals and birds. This is the first report where gross, histological, and immunohistochemical characteristics of CHCC in a bird are described, and the first report of CHCC in a lesser flamingo...

Research Grants60

  1. A novel telomerase expressing lung fibroblast phenotype
    Sem H Phan; Fiscal Year: 2012
    ..additional novel potential targets for therapy of fibrotic diseases that are progressive and often have a fatal outcome. PUBLIC HEALTH RELEVANCE: This research project will analyze the role of an enzyme complex called telomerase ..
  2. Tick-Mammal Interface of Human Granulocytic Anaplasmosis
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..sudden onset of high fever during the summer months requiring hospitalization for 40% of patients and has a fatal outcome in ~5% of clinical cases. The research proposed herein will reveal differences in the genetic code of A...
  3. MYOFIBROBLASTS IN PULMONARY FIBROSIS
    Sem H Phan; Fiscal Year: 2012
    ..or agents may result in a stereotypic response leading to fibrosis and end stage lung disease with a potential fatal outcome. The long term objectives of this project are to determine the mechanisms underlying the genesis of the ..
  4. Environmental Triggers of Eating Seizures in Nodding Syndrome
    Peter S Spencer; Fiscal Year: 2013
    ..time, head nodding may advance to tonic-clonic seizures, wasting, and cognitive deficits, eventually with a fatal outcome. Preliminary studies show that Nodding Syndrome is associated with skin infection with the nematode worm ..
  5. ADAM17 in pancreatic cancer and pancreatitis
    Howard C Crawford; Fiscal Year: 2013
    ..by applicant): Pancreatic ductal adenocarcinoma is a relatively uncommon cancer with an almost universally fatal outcome. Chronic pancreatitis (CP) is a risk factor for pancreatic ductal adenocarcinoma (PDA), presumably due to the ..
  6. NLRP1 activation induces deletion of hematopoietic progenitor cells
    BEN ADAM CROKER; Fiscal Year: 2013
    ..applicant): Peripheral blood cytopenias in patients with systemic infection are well-established predictors of fatal outcome despite antimicrobial therapy...
  7. Transfusion in Malaria
    Walter H Dzik; Fiscal Year: 2013
    ..Secondly, lactic acidosis accompanies severe malaria anemia and is a strong predictor of fatal outcome. Thirdly, small studies have suggested that RBC transfusion is highly effective to reverse lactic acidosis in ..
  8. Pathogenesis of Salmonella bacteremia
    Renee M Tsolis; Fiscal Year: 2013
    ..Africa, where these infections are associated with bacteremia, meningitis and sepsis, and often have a fatal outcome. In young children, epidemiologic studies have determined that severe malaria is an important ..
  9. ANALYSIS OF STAPHYLOCOCCUS AUREUS HOST INTERACTIONS
    AXEL MAGNUS HOOK; Fiscal Year: 2013
    ..The molecular interactions and pathways leading to the fatal outcome will be determined using a combination of mutated MSCRAMMs and specific mouse lines harboring specifically ..
  10. NIAMS: CORT
    ROBERT A LAFYATIS; Fiscal Year: 2013
    ..sclerosis (SSc) is a rare, complex rheumatic disease involving multiple organ systems with a frequently fatal outcome. It remains perhaps the most difficult rheumatic disease to manage, with limited effective therapies...
  11. High-density lipoprotein and A. fumigatus pathogenesis
    David S Askew; Fiscal Year: 2013
    ..2 will determine the contribution of apoA-I to AF-induced inflammation and its relationship to fatal outcome in mouse models of IA...
  12. Pathogenesis of a JC Virus Variant in Pyramidal Neurons
    Igor J Koralnik; Fiscal Year: 2013
    ..gray matter on MRI, developed aphasia, progressive cognitive dysfunction and seizures and had a rapid fatal outcome. We called this disease JCV encephalopathy (JCVE), since it is distinct from Progressive Multifocal ..
  13. Rheumatic Diseases Research Core Centers
    ROBERT A LAFYATIS; Fiscal Year: 2013
    ..Systemic sclerosis (SSc) is a rare, complex rheumatic disease involving multiple organ systems with a frequently fatal outcome. It remains one of the most difficult rheumatic disease to manage, with limited effective therapies...
  14. Treating Older Patients with Major Depression and Severe COPD
    George S Alexopoulos; Fiscal Year: 2012
    ..a variety of chronic, debilitating disorders, who often develop depression, give up, and have a poor and often fatal outcome. As a major focus of PST-AE is improvement of treatment adherence, this approach to the care of depressed, ..
  15. Visceral Leishmaniasis in Bihar State, India
    Shyam Sundar; Fiscal Year: 2013
    ..aimed at understanding the ever evading immunosuppressive pathways that account for severe progression and fatal outcome of untreated VL...
  16. Phase 1/2 of AT-101 With Lenalidomide for Tx of Chronic Lymphocytic Leukemia
    Asher A Chanan-Khan; Fiscal Year: 2012
    ..Although CLL patients initially respond to combination chemotherapy regimen(s), eventually all relapse with fatal outcome. Development of new drugs for this cancer remains an important unmet need...
  17. A novel Anti-endotoxin Peptide for Septic Shock
    Xiao Jia Chang; Fiscal Year: 2010
    ..its target and thus prevent the initiation of a self-amplifying cascade of inflammatory events with a possibly fatal outcome. The data obtained in this study may support further development of CN16 as a clinical development candidate.
  18. TDP-43 and FUS RNA pathways in motor neuron degeneration
    Zissimos Mourelatos; Fiscal Year: 2011
    ..Amyotrophic lateral sclerosis (ALS) is the most common human motor neuron degenerative disease with a fatal outcome and without a cure...
  19. Biophysical and molecular dialogue of glioma cells and the brain microenvironment
    Valerie Marie Weaver; Fiscal Year: 2013
    ..Consequently GBM invariably have a fatal outcome. The aggressive nature of GBM has been attributed to their intrinsic genetic mutations and stem-like origins...
  20. Focal Adhesion Kinase and FAK-related Non-kinase in Idiopathic Pulmonary Fibrosis
    Qiang Ding; Fiscal Year: 2010
    ..IPF) is a chronic lung disorder resulting in progressive respiratory insufficiency and lung fibrosis with fatal outcome. The pathogenesis of IPF remains unclear. Currently, there is no effective therapy to cure IPF...
  21. Inhibitors of ADAMTS313 and Outcome of TTP
    Han Mou Tsai; Fiscal Year: 2004
    ..Plasma exchange has been the mainstay of treatment for TTP, preventing a fatal outcome in 70%-90% of the cases. However, among the patients who achieve remission, 30%-60% develop relapses...
  22. Type I interferon in LPS/CpG-induced lethal toxic shock
    Jean van Seventer; Fiscal Year: 2005
    ..I IFN during sepsis will inhibit bacterial-induced inflammation and toxicity to such a degree as to prevent a fatal outcome. The goal of this proposal is to characterize the role of type I IFN in lethal toxic shock induced by Gram ..
  23. SYNTHETIC PEPTIDE AS CAPTURE AG FOR PARVOVIRUS B19 IGG/M
    PAUL MARIE HONHON; Fiscal Year: 1990
    ..a transient arthritis, and aplastic crisis in sickle cell anemia patients, and hydrops fetalis (a usually fatal outcome of pregnan- cy)...
  24. A MULTI-CENTER THERAPY TRIAL FOR ACUTE LIVER FAILURE
    William Lee; Fiscal Year: 2004
    ..occurs rapidly leading to severe multi-organ failure requiring high resource utilization and, frequently, a fatal outcome. Prior to 1997, little research had been performed in the US regarding this condition because of the lack of a ..
  25. ANTIBODIES TO INVESTIGATE AND TREAT NEUROBLASTOMA
    Christopher Frantz; Fiscal Year: 1992
    ..Amplification of the N-myc oncogene in the tumor cells is highly correlated with metastasis and fatal outcome. In order to understand the above phenomena and to have an impact on the treatment of this disease in the ..
  26. Peroxynitrite decomposition catalyst: hemorrhagic shock
    Jon Mabley; Fiscal Year: 2002
    ..In a small proportion of trauma, a fatal outcome is assured due to the irreversible loss of vital functions or massive blood loss...
  27. Fibroproliferative ARDS: mechanisms of cell death/repair
    Ruairi Fahy; Fiscal Year: 2005
    ..Advanced fibrosis has been linked to a fatal outcome. The driving force behind this fibrosis is unclear...
  28. Catalytic antioxidant for hemorrhagic shock
    Kanneganti Murthy; Fiscal Year: 2005
    ..In a small proportion of trauma, a fatal outcome is assured due to the irreversible loss of vital functions or massive blood loss...
  29. SYSTEMIC T CELL IMMUNOTHERAPY OF MALIGNANT GLIOMAS
    Suyu Shu; Fiscal Year: 2001
    Malignant brain tumors such as glioblastoma multiforme and anaplastic astrocytoma usually have a fatal outcome in spite of advances in diagnostic and treatment procedures...
  30. TYPE 1 VS TYPE 2 CYTOKINE RESPONSE DURING FIV INFECTION
    Paul Avery; Fiscal Year: 2000
    ..the patterns of TH1-like and TH2-like cytokine expression which may accompany infection and progression to a fatal outcome. An Advisory Committee is available to guide and review the candidate's research progress. e...
  31. Alcoholism In Women with Anorexia and Bulimia Nervosa
    David Herzog; Fiscal Year: 2004
    ..subset have died, resulting in 60 remaining subjects with a lifetime history of ALC2 Preliminary analyses show fatal outcome was associated with severity of ALC over the course of follow-up, even after controlling for age and duration ..
  32. Genomic Studies in a Rodent Model of Pulmonary Hypertension: A Consomics Approach
    Ankit A Desai; Fiscal Year: 2010
    ..knowledge of these modifier genes will empower us to translate the information into novel therapeutic pathways to improve the fatal outcome of the disease and provide the PI an outstanding experience in translational research.
  33. POLYMORPHIC UPSTREAM STRUCTURE & PFG 27/25 GENE CONTROL
    Ute Frevert; Fiscal Year: 2001
    ..The 5' terminus of the Pfg27/25 mRNAs will also be determined to see where the transcription start sites occur with respect to the boundaries of the polymorphic domain. ..
  34. Development of a Spinal Intervertebral Disc Prosthesis
    GLENN BUTTERMANN; Fiscal Year: 2003
    ..The objective of Phase I is to demonstrate that the device restores normal spine biomechanics (range of motion and stiffness) and is durable in fatigue testing. ..
  35. Interdisciplinary Training-Alcohol, Injury, & Violence
    Susan Baker; Fiscal Year: 2005
    ..The program aims to develop creative and independent investigators, well prepared to contribute to amelioration of alcohol-related injury. ..
  36. Central Nervous System Infections in Peru
    Joseph Zunt; Fiscal Year: 2004
    ..The second year will be used to complete and analyze these pilot studies and prepare the R01 application. ..
  37. CD4 Immune Reconstitution in SIV Infection
    Francois Villinger; Fiscal Year: 2007
    ..Results of these studies will form the basis for future immune reconstitution strategies in human HIV infected patients. ..
  38. Prostate Cancer Chemoprevention by Apigenin
    Sanjay Gupta; Fiscal Year: 2003
    ..These studies could be considered as a starting point for an expanded program for the development of apigenin as a promising agent against CaP in humans. ..
  39. NEUROLOGIC/IMMUNOLOGIC MANIFESTATION OF HTLV-I INFECTION
    Joseph Zunt; Fiscal Year: 2004
    ....
  40. Inhibition of Prostate Carcinogenesis by Apigenin
    Sanjay Gupta; Fiscal Year: 2003
    ..A successful completion of this application will set a platform to define the role of apigenin as a promising agent against prevention and possibly therapy of prostate cancer in humans. ..
  41. Bioengineering Methods to Study Blood Substitutes
    Anthony Cheung; Fiscal Year: 2004
    ..abstract_text> ..
  42. Anti-proliferative Effects of D-limonene against Prosta*
    Sanjay Gupta; Fiscal Year: 2005
    ..Successful completion of this application will establish the cancer chemopreventive and/or therapeutic potential of D-limonene against prostate cancer and mechanisms involved with its anti-proliferative response. ..
  43. Retrovial Infections of the Nervous System in Peru
    JOSEPH RAYMOND ZUNT; Fiscal Year: 2010
    ..In addition to continuing our investigations, we plan to continue training activities to address the research, education, training, and mentoring needs and opportunities related to CNS infection identified during the R21 planning grant. ..
  44. Reactivation of GSTP1 Gene by Green Tea Polyphenols
    Sanjay Gupta; Fiscal Year: 2005
    ..abstract_text> ..
  45. International Multispecialty Conference on PDD and DLB
    Carol Lippa; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  46. Innate immune evasion and/or antagonism by eastern equine encephalitis virus
    KATHERINE RYMAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  47. Measurement & modulation of the mutation rate in humans
    David Araten; Fiscal Year: 2007
    ..These studies will begin to elucidate the relationship between f and cancer risk and provide a highly relevant in vitro parameter with which to evaluate chemoprevention. ..
  48. Functional and Tissue Specific Effects of VHL Mutations
    WENDY RATHMELL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  49. Persistent Reservoirs of HIV-1 Infection
    DANIEL FIERER; Fiscal Year: 2006
    ..These studies will also provide me with the opportunity to develop the required skills to reach my long-term goal: a career as an independent investigator and academician performing patient-oriented translational research...
  50. Developmental Research on Elder Mistreatment
    Laura Mosqueda; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  51. Impact of ileal content on S typhimurium pathogenesis
    Sara Lawhon; Fiscal Year: 2006
    ..The research collaboration between Dr. B[unreadable]umler in the Texas A&M Health Science Center and Dr. Adams in the College of Veterinary Medicine provides a unique opportunity to achieve this career goal. ..
  52. Role of Signal Transduction in Burn and Wound Healing
    Saman Arbabi; Fiscal Year: 2008
    ..The candidate will gain knowledge of advanced techniques under the tutlelage of Dr. Stewart C. Wang, while working on the research proposal. The goal is for the candidate to become an independent researcher with his own grants. ..
  53. Transmission genetics of mammalian mitochondrial DNA
    Eric Shoubridge; Fiscal Year: 2008
    ..abstract_text> ..
  54. Chamomile as Medicine for Prostate cancer
    Sanjay Gupta; Fiscal Year: 2009
    ..Completion of the proposed studies will provide a 'head start'to initiate clinical trials in prostate cancer patients and/or high-risk individuals. ..
  55. Plasmodium Sporozoite-Kupffer Cell Passage
    Ute Frevert; Fiscal Year: 2006
    ..Finally, we wish to compare the data obtained from these animal models with the interaction between human Kupffer cells and P. falciparum sporozoites. ..
  56. Imaging preerythrocytic Plasmodium stages in naive and immune individuals
    Ute Frevert; Fiscal Year: 2010
    ..Direct visualization and molecular analysis of target cell killing, the pinnacle of T cell immunity, will greatly advance our understanding of the adaptive cell-mediated immune response against malaria liver stages. ..
  57. Cadmium, Metallothionein and Breast Cancer Progression
    MARY SENS; Fiscal Year: 2008
    ..abstract_text> ..
  58. MANAGEMENT FOR RISK OF RELAPSE IN SCHIZOPHRENIA
    Stephen Marder; Fiscal Year: 2004
    ..The investigator will evaluate outcome during the next two years with measures of clinical psychopathology, medication side effects, functional outcomes, and quality of life. ..
  59. TREATMENT OF NEGATIVE SYMPTOMS & COGNITIVE IMPAIRMENTS
    Stephen Marder; Fiscal Year: 2003
    ..The study will provide new information on the efficacy of d- cycloserine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
  60. Diet treatment of Galactosemic Infants: A Pilot Study
    Can Ficicioglu; Fiscal Year: 2007
    ..Evidence from this study may have a future impact on how newborn galactosemics are treated with a potential for moderating long-term complications. [unreadable] [unreadable]..