mortality

Summary

Summary: All deaths reported in a given population.

Top Publications

  1. doi Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
    Rafael Lozano
    Institute for Health Metrics and Evaluation, Seattle, WA, USA
    Lancet 380:2095-128. 2012
  2. pmc Projections of global mortality and burden of disease from 2002 to 2030
    Colin D Mathers
    Evidence and Information for Policy Cluster, World Health Organization, Geneva, Switzerland
    PLoS Med 3:e442. 2006
  3. doi Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012
    J Ferlay
    Section of Cancer Information, International Agency for Research on Cancer IARC, France
    Eur J Cancer 49:1374-403. 2013
  4. ncbi Parkinsonism: onset, progression and mortality
    M M Hoehn
    Neurology 17:427-42. 1967
  5. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
  6. pmc Body-mass index and mortality among 1.46 million white adults
    Amy Berrington de Gonzalez
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    N Engl J Med 363:2211-9. 2010
  7. pmc Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
    Lancet 375:2073-81. 2010
  8. ncbi Selected major risk factors and global and regional burden of disease
    Majid Ezzati
    Risk, Resources and Environmental Management Division, Resources for the Future, Washington, DC, USA
    Lancet 360:1347-60. 2002
  9. doi Global patterns of cancer incidence and mortality rates and trends
    Ahmedin Jemal
    Surveillance and Health Policy Research Department, American Cancer Society, 250 Williams Street Northwest, Atlanta, GA 30303 1002, USA
    Cancer Epidemiol Biomarkers Prev 19:1893-907. 2010
  10. ncbi Exercise capacity and mortality among men referred for exercise testing
    Jonathan Myers
    Division of Cardiovascular Medicine, Stanford University Medical Center and the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif CA 94304, USA
    N Engl J Med 346:793-801. 2002

Research Grants

  1. Congenital and neonatal malaria in Mali
    Abdoulaye Djimde; Fiscal Year: 2006
  2. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
  3. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
  4. Yasmin Wadia; Fiscal Year: 2014
  5. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
  6. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
  7. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
  8. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
  9. Ian C Michelow; Fiscal Year: 2016
  10. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010

Detail Information

Publications395 found, 100 shown here

  1. doi Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
    Rafael Lozano
    Institute for Health Metrics and Evaluation, Seattle, WA, USA
    Lancet 380:2095-128. 2012
    ....
  2. pmc Projections of global mortality and burden of disease from 2002 to 2030
    Colin D Mathers
    Evidence and Information for Policy Cluster, World Health Organization, Geneva, Switzerland
    PLoS Med 3:e442. 2006
    Global and regional projections of mortality and burden of disease by cause for the years 2000, 2010, and 2030 were published by Murray and Lopez in 1996 as part of the Global Burden of Disease project...
  3. doi Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012
    J Ferlay
    Section of Cancer Information, International Agency for Research on Cancer IARC, France
    Eur J Cancer 49:1374-403. 2013
    Cancer incidence and mortality estimates for 25 cancers are presented for the 40 countries in the four United Nations-defined areas of Europe and for the European Union (EU-27) for 2012.
  4. ncbi Parkinsonism: onset, progression and mortality
    M M Hoehn
    Neurology 17:427-42. 1967
  5. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
    ..To compare the hazards of cigarette smoking in men who formed their habits at different periods, and the extent of the reduction in risk when cigarette smoking is stopped at different ages...
  6. pmc Body-mass index and mortality among 1.46 million white adults
    Amy Berrington de Gonzalez
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    N Engl J Med 363:2211-9. 2010
    ..index (BMI, the weight in kilograms divided by the square of the height in meters) is associated with increased mortality from cardiovascular disease and certain cancers, but the precise relationship between BMI and all-cause ..
  7. pmc Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 2024 E Monument, Suite 2 630, Baltimore, MD 21287, USA
    Lancet 375:2073-81. 2010
    ..We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality.
  8. ncbi Selected major risk factors and global and regional burden of disease
    Majid Ezzati
    Risk, Resources and Environmental Management Division, Resources for the Future, Washington, DC, USA
    Lancet 360:1347-60. 2002
    ..Causal attribution of morbidity and mortality to risk factors has traditionally been in the context of individual risk factors, often in a limited number of ..
  9. doi Global patterns of cancer incidence and mortality rates and trends
    Ahmedin Jemal
    Surveillance and Health Policy Research Department, American Cancer Society, 250 Williams Street Northwest, Atlanta, GA 30303 1002, USA
    Cancer Epidemiol Biomarkers Prev 19:1893-907. 2010
    While incidence and mortality rates for most cancers (including lung, colorectum, female breast, and prostate) are decreasing in the United States and many other western countries, they are increasing in several less developed and ..
  10. ncbi Exercise capacity and mortality among men referred for exercise testing
    Jonathan Myers
    Division of Cardiovascular Medicine, Stanford University Medical Center and the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif CA 94304, USA
    N Engl J Med 346:793-801. 2002
    ..an important prognostic factor in patients with cardiovascular disease, but it is uncertain whether it predicts mortality equally well among healthy persons...
  11. doi Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study
    Chi Pang Wen
    Institute of Population Science, National Health Research Institutes, Zhunan, Taiwan
    Lancet 378:1244-53. 2011
    ..We assessed the health benefits of a range of volumes of physical activity in a Taiwanese population...
  12. pmc Objectively measured physical capability levels and mortality: systematic review and meta-analysis
    Rachel Cooper
    MRC Unit for Lifelong Health and Ageing and Division of Population Health, University College London, London WC1B 5JU
    BMJ 341:c4467. 2010
    ..and unpublished data, examining the associations between individual objective measures of physical capability (grip strength, walking speed, chair rising, and standing balance times) and mortality in community dwelling populations.
  13. doi Sitting time and all-cause mortality risk in 222 497 Australian adults
    Hidde P van der Ploeg
    Sydney School of Public Health, University of Sydney, Sydney, NSW 2006, Australia
    Arch Intern Med 172:494-500. 2012
    ..detrimental to health, but evidence regarding the independent relationship of total sitting time with all-cause mortality is limited. This study aimed to determine the independent relationship of sitting time with all-cause mortality.
  14. pmc Association of socioeconomic position with health behaviors and mortality
    Silvia Stringhini
    Inserm U1018, Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, Bât 15 16, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    JAMA 303:1159-66. 2010
    Previous studies may have underestimated the contribution of health behaviors to social inequalities in mortality because health behaviors were assessed only at the baseline of the study.
  15. ncbi A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?
    Sukanta Saha
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol Q4076, Australia
    Arch Gen Psychiatry 64:1123-31. 2007
    Despite improvements in mental health services in recent decades, it is unclear whether the risk of mortality in schizophrenia has changed over time.
  16. pmc Weather-related mortality: how heat, cold, and heat waves affect mortality in the United States
    Brooke G Anderson
    Environmental Engineering Program, Yale University, New Haven, CT, USA
    Epidemiology 20:205-13. 2009
    Many studies have linked weather to mortality; however, role of such critical factors as regional variation, susceptible populations, and acclimatization remain unresolved.
  17. pmc 25-hydroxyvitamin D levels and the risk of mortality in the general population
    Michal L Melamed
    Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Ullmann 615, Bronx, NY 10461, USA
    Arch Intern Med 168:1629-37. 2008
    ..dialysis, therapy with calcitriol or paricalcitol or other vitamin D agents is associated with reduced mortality. Observational data suggests that low 25-hydroxyvitamin D levels (25[OH]D) are associated with diabetes mellitus,..
  18. pmc Social relationships and mortality risk: a meta-analytic review
    Julianne Holt-Lunstad
    Department of Psychology, Brigham Young University, Provo, Utah, United States of America
    PLoS Med 7:e1000316. 2010
    The quality and quantity of individuals' social relationships has been linked not only to mental health but also to both morbidity and mortality.
  19. pmc 50-year trends in smoking-related mortality in the United States
    Michael J Thun
    Department of Epidemiology, American Cancer Society, Atlanta, GA 30303 1002, USA
    N Engl J Med 368:351-64. 2013
    ..Whether these risks have continued to increase during the past 20 years is unclear...
  20. pmc Daily sitting time and all-cause mortality: a meta-analysis
    Josephine Y Chau
    Prevention Research Collaboration, School of Public Health, University of Sydney, Sydney, Australia
    PLoS ONE 8:e80000. 2013
    To quantify the association between daily total sitting and all-cause mortality risk and to examine dose-response relationships with and without adjustment for moderate-to-vigorous physical activity.
  21. ncbi Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults
    Shaista Malik
    Heart Disease Prevention Program, University of California, Irvine 92697, USA
    Circulation 110:1245-50. 2004
    b>Mortality resulting from coronary heart disease (CHD), cardiovascular disease (CVD), and all causes in persons with diabetes and pre-existing CVD is high; however, these risks compared with those with metabolic syndrome (MetS) are ..
  22. pmc Milk and dairy consumption and incidence of cardiovascular diseases and all-cause mortality: dose-response meta-analysis of prospective cohort studies
    Sabita S Soedamah-Muthu
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Am J Clin Nutr 93:158-71. 2011
    The consumption of dairy products may influence the risk of cardiovascular disease (CVD) and total mortality, but conflicting findings have been reported.
  23. doi Association of particulate air pollution with daily mortality: the China Air Pollution and Health Effects Study
    Renjie Chen
    School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China
    Am J Epidemiol 175:1173-81. 2012
    ..the association of particulate matter with an aerodynamic diameter of less than 10 μm (PM(10)) with daily mortality in 16 Chinese cities between 1996 and 2008...
  24. pmc Association of sedentary time with mortality independent of moderate to vigorous physical activity
    Annemarie Koster
    National Institute on Aging, Intramural Research Program, Laboratory of Epidemiology, Demography, and Biometry, Bethesda, Maryland, United States of America
    PLoS ONE 7:e37696. 2012
    ..Previous studies have shown self-reported sedentary time to be associated with mortality; however, no studies have investigated the effect of objectively measured sedentary time on mortality ..
  25. ncbi Self-rated health and mortality: a review of twenty-seven community studies
    E L Idler
    Institute for Health, Health Care Policy, and Aging Research, Rutgers, State University of New Jersey, New Brunswick 08903, USA
    J Health Soc Behav 38:21-37. 1997
    We examine the growing number of studies of survey respondents' global self-ratings of health as predictors of mortality in longitudinal studies of representative community samples. Twenty-seven studies in U.S...
  26. ncbi Estimates of the cancer incidence and mortality in Europe in 2006
    J Ferlay
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Ann Oncol 18:581-92. 2007
    Monitoring the evolution of the cancer burden in Europe is of great value. Estimates of the cancer burden in Europe have been published for 2004 and estimates are now being presented for cancer incidence and mortality in Europe for 2006.
  27. ncbi Association between telomere length in blood and mortality in people aged 60 years or older
    Richard M Cawthon
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Lancet 361:393-5. 2003
    ..We aimed to assess an association between telomere length and mortality in 143 normal unrelated individuals over the age of 60 years...
  28. ncbi Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality
    Edgar R Miller
    The Johns Hopkins School of Medicine, and The Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2223, USA
    Ann Intern Med 142:37-46. 2005
    ..However, several trials of high-dosage vitamin E supplementation showed non-statistically significant increases in total mortality.
  29. pmc Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control
    Ahmedin Jemal
    Epidemiology and Surveillance Research, American Cancer Society, Atlanta, GA 30303 1002, USA
    J Natl Cancer Inst 100:1672-94. 2008
    ..This year's report includes trends in lung cancer incidence and death rates, tobacco use, and tobacco control by state of residence...
  30. pmc Distributed lag non-linear models
    A Gasparrini
    Public Health and Policy Department, London School of Hygiene and Tropical Medicine, Keppel Street, London W1C 7HT, U K
    Stat Med 29:2224-34. 2010
    ..To illustrate the methodology we use examples of DLNMs to represent the relationship between temperature and mortality, using data from the National Morbidity, Mortality, and Air Pollution Study (NMMAPS) for New York during the ..
  31. pmc Television viewing and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a meta-analysis
    Anders Grøntved
    Institute of Sport Science and Clinical Biomechanics, Department of Exercise Epidemiology, Center of Research in Childhood Health, University of Southern Denmark, Odense
    JAMA 305:2448-55. 2011
    ..viewing is the most prevalent and pervasive sedentary behavior in industrialized countries and has been associated with morbidity and mortality. However, a systematic and quantitative assessment of published studies is not available.
  32. pmc Measuring adult mortality using sibling survival: a new analytical method and new results for 44 countries, 1974-2006
    Ziad Obermeyer
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America
    PLoS Med 7:e1000260. 2010
    ..Although no comparable effort has been undertaken for adult mortality, the availability of large datasets with information on adult survival from censuses and household surveys ..
  33. pmc Red meat consumption and mortality: results from 2 prospective cohort studies
    An Pan
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 172:555-63. 2012
    Red meat consumption has been associated with an increased risk of chronic diseases. However, its relationship with mortality remains uncertain.
  34. pmc Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials
    Lars Rejnmark
    Dr Med Sc, AssociateAarhus University, Department of Endocrinology and Internal Medicine, Aarhus Sygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 97:2670-81. 2012
    Vitamin D may affect multiple health outcomes. If so, an effect on mortality is to be expected...
  35. doi Prostate cancer incidence and mortality trends in 37 European countries: an overview
    F Bray
    Cancer Information Section, International Agency for Research on Cancer, Lyon, France
    Eur J Cancer 46:3040-52. 2010
    ..The highest prostate cancer mortality rates are in the Baltic region (Estonia, Latvia and Lithuania) and in Denmark, Norway and Sweden...
  36. pmc Reduced mortality after allogeneic hematopoietic-cell transplantation
    Ted A Gooley
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    N Engl J Med 363:2091-101. 2010
    ..Over the past decade, advances have been made in the care of patients undergoing transplantation. We conducted a study to determine whether these advances have improved the outcomes of transplantation...
  37. doi Global patterns of mortality in young people: a systematic analysis of population health data
    George C Patton
    Centre for Adolescent Health and Murdoch Children s Research Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    Lancet 374:881-92. 2009
    Pronounced changes in patterns of health take place in adolescence and young adulthood, but the effects on mortality patterns worldwide have not been reported...
  38. ncbi Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients
    S Laurent
    Department of Pharmacology and INSERM U 337, Broussais Hospital, Paris, France
    Hypertension 37:1236-41. 2001
    ..reported that pulse pressure, an indirect index of arterial stiffening, was an independent risk factor for mortality, a direct relationship between arterial stiffness and all-cause and cardiovascular mortality remained to be ..
  39. ncbi Temperature and mortality in 11 cities of the eastern United States
    Frank C Curriero
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Am J Epidemiol 155:80-7. 2002
    Episodes of extremely hot or cold temperatures are associated with increased mortality. Time-series analyses show an association between temperature and mortality across a range of less extreme temperatures...
  40. ncbi Adherence to a Mediterranean diet and survival in a Greek population
    Antonia Trichopoulou
    Department of Hygiene and Epidemiology, University of Athens Medical School, Athens, Greece
    N Engl J Med 348:2599-608. 2003
    ..Adherence to a Mediterranean diet may improve longevity, but relevant data are limited...
  41. doi Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis
    Satoru Kodama
    Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine, 3 2 7 Miya machi, Mito, Ibaraki 310 0015, Japan
    JAMA 301:2024-35. 2009
    Epidemiological studies have indicated an inverse association between cardiorespiratory fitness (CRF) and coronary heart disease (CHD) or all-cause mortality in healthy participants.
  42. ncbi Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population
    Hans L Hillege
    Trial Coordination Center, Department of Cardiology, University Hospital of Groningen, Groningen, The Netherlands
    Circulation 106:1777-82. 2002
    ..Therefore, we examined the relationship between urinary albumin excretion and all-cause mortality and mortality caused by cardiovascular (CV) disease and non-CV disease in the general population.
  43. pmc Losing life and livelihood: a systematic review and meta-analysis of unemployment and all-cause mortality
    David J Roelfs
    Department of Sociology, Stony Brook University, S 401 SBS Building, Stony Brook, NY 11794 4356, USA
    Soc Sci Med 72:840-54. 2011
    ..effects meta-analysis and meta-regression designed to assess the association between unemployment and all-cause mortality among working-age persons...
  44. doi Cardiac complications in patients with community-acquired pneumonia: incidence, timing, risk factors, and association with short-term mortality
    Vicente F Corrales-Medina
    Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Circulation 125:773-81. 2012
    ..Although incident cardiac complications occur in patients with community-acquired pneumonia, their incidence, timing, risk factors, and associations with short-term mortality are not well understood.
  45. doi Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases
    Goran Bjelakovic
    Department of InternalMedicine, Medical Faculty, University ofNis, Nis, Serbia
    Cochrane Database Syst Rev . 2012
    Our systematic review has demonstrated that antioxidant supplements may increase mortality. We have now updated this review.
  46. doi A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: the CopD study
    D Durup
    Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 97:2644-52. 2012
    Optimal levels of vitamin D have been a topic of heavy debate, and the correlation between 25-hydroxyvitamin D [25(OH)D] levels and mortality still remains to be established.
  47. doi The effect of temperature on mortality in rural Bangladesh--a population-based time-series study
    Masahiro Hashizume
    Institute of Tropical Medicine, Nagasaki University, 1 12 4, Sakamoto, Nagasaki 852 8523, Japan
    Int J Epidemiol 38:1689-97. 2009
    Studies in urban cities have consistently shown evidence of increased mortality in association with hot and cold weather. However, few studies have examined temperature-mortality relationship in the rural areas of developing countries...
  48. doi Age-specific and sex-specific mortality in 187 countries, 1970-2010: a systematic analysis for the Global Burden of Disease Study 2010
    Haidong Wang
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA 98121, USA
    Lancet 380:2071-94. 2012
    ..is a key first stage for calculation of the burden of disease in order to constrain estimates of cause-specific mortality and to measure premature mortality in populations...
  49. ncbi Relative risk of cardiovascular and cancer mortality in people with severe mental illness from the United Kingdom's General Practice Rsearch Database
    David P J Osborn
    Department of Mental Health Sciences, Royal Free Medical School, London, England
    Arch Gen Psychiatry 64:242-9. 2007
    People with severe mental illness (SMI) appear to have an elevated risk of death from cardiovascular disease, but results regarding cancer mortality are conflicting.
  50. ncbi The validity of the diagnosis of acute myocardial infarction in routine statistics: a comparison of mortality and hospital discharge data with the Danish MONICA registry
    Mette Madsen
    National Institute of Public Health, Svanemøllevej 25, DK 2100 Copenhagen, Denmark
    J Clin Epidemiol 56:124-30. 2003
    ..The combination of the national registries was found to be a valid and powerful tool for monitoring the population incidence of MI...
  51. pmc Combined impact of health behaviours and mortality in men and women: the EPIC-Norfolk prospective population study
    Kay Tee Khaw
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    PLoS Med 5:e12. 2008
    ..We aimed to quantify the potential combined impact of four health behaviours on mortality in men and women living in the general community.
  52. pmc Heat waves in the United States: mortality risk during heat waves and effect modification by heat wave characteristics in 43 U.S. communities
    G Brooke Anderson
    Environmental Engineering Program, Yale University, New Haven, Connecticut, USA
    Environ Health Perspect 119:210-8. 2011
    ..Devastating health effects from recent heat waves, and projected increases in frequency, duration, and severity of heat waves from climate change, highlight the importance of understanding health consequences of heat waves...
  53. pmc The impact of temperature on mortality in Tianjin, China: a case-crossover design with a distributed lag nonlinear model
    Yuming Guo
    School of Public Health, Queensland University of Technology, Brisbane, Australia
    Environ Health Perspect 119:1719-25. 2011
    Although interest in assessing the impacts of temperature on mortality has increased, few studies have used a case-crossover design to examine nonlinear and distributed lag effects of temperature on mortality...
  54. ncbi Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies
    Abel Romero-Corral
    Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, MN 55905, USA
    Lancet 368:666-78. 2006
    Studies of the association between obesity, and total mortality and cardiovascular events in patients with coronary artery disease (CAD) have shown contradictory results...
  55. ncbi Widening socioeconomic inequalities in mortality in six Western European countries
    Johan P Mackenbach
    Department of Public Health, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Int J Epidemiol 32:830-7. 2003
    ..Although differential mortality decline for cardiovascular diseases has been suggested as an important contributory factor, it is not known what ..
  56. pmc High ambient temperature and mortality: a review of epidemiologic studies from 2001 to 2008
    Rupa Basu
    California Office of Environmental Hazard Assessment, Air Pollution Epidemiology Section, Oakland, California, USA
    Environ Health 8:40. 2009
    This review examines recent evidence on mortality from elevated ambient temperature for studies published from January 2001 to December 2008.
  57. pmc Adult mortality and probable cause of death in rural northern Malawi in the era of HIV treatment
    Menard Chihana
    Karonga Prevention Study, Chilumba, Malawi
    Trop Med Int Health 17:e74-83. 2012
    Developing countries are undergoing demographic transition with a shift from high mortality caused by communicable diseases (CD) to lower mortality rates caused by non-communicable diseases (NCD)...
  58. doi Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels
    Rebecca Vigen
    The University of Texas at Southwestern Medical Center, Dallas
    JAMA 310:1829-36. 2013
    ..of testosterone therapy are increasing and the effects of testosterone therapy on cardiovascular outcomes and mortality are unknown...
  59. pmc Exposure measurement error in time-series studies of air pollution: concepts and consequences
    S L Zeger
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 108:419-26. 2000
    ..of measurement errors in the log-linear regression used for time-series studies of particulate air pollution and mortality and identify three main components of error...
  60. doi General and abdominal adiposity and risk of death in Europe
    T Pischon
    Department of Epidemiology, German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    N Engl J Med 359:2105-20. 2008
    ....
  61. doi Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women
    Dana Bliuc
    Garvan Institute of Medical Research, 384 Victoria St, Sydney, NSW 2010, Australia
    JAMA 301:513-21. 2009
    There are few data on long-term mortality following osteoporotic fracture and fewer following subsequent fracture.
  62. ncbi The Malmö Diet and Cancer Study: representativity, cancer incidence and mortality in participants and non-participants
    J Manjer
    Department of Community Medicine, Lund University, , Sweden
    Eur J Cancer Prev 10:489-99. 2001
    ..n = 40807) in the Malmö Diet and Cancer Study (MDCS) were compared with regard to cancer incidence and mortality. MDCS participants were also compared with participants in a mailed health survey with regard to subjective ..
  63. ncbi Impact of high temperatures on mortality: is there an added heat wave effect?
    Shakoor Hajat
    London School of Hygiene and Tropical Medicine, London, UK
    Epidemiology 17:632-8. 2006
    b>Mortality during sustained periods of hot weather is generally regarded as being in excess of what would be predicted from smooth temperature-mortality gradients estimated using standard time-series regression models...
  64. ncbi Models for the relationship between ambient temperature and daily mortality
    Ben Armstrong
    London School of Hygiene and Tropical Medicine, London, UK
    Epidemiology 17:624-31. 2006
    Ambient temperature is an important determinant of daily mortality that is of interest both in its own right and as a confounder of other determinants investigated using time-series regressions, in particular, air pollution...
  65. pmc Mortality of HIV-infected patients starting antiretroviral therapy in sub-Saharan Africa: comparison with HIV-unrelated mortality
    Martin W G Brinkhof
    Institute of Social and Preventive Medicine ISPM, University of Bern, Switzerland
    PLoS Med 6:e1000066. 2009
    b>Mortality in HIV-infected patients who have access to highly active antiretroviral therapy (ART) has declined in sub-Saharan Africa, but it is unclear how mortality compares to the non-HIV-infected population...
  66. doi International study of temperature, heat and urban mortality: the 'ISOTHURM' project
    Anthony J McMichael
    National Centre for Epidemiology and Population Health, The Australian National University College of Medicine and Health Sciences, Canberra, Australia
    Int J Epidemiol 37:1121-31. 2008
    This study describes heat- and cold-related mortality in 12 urban populations in low- and middle-income countries, thereby extending knowledge of how diverse populations, in non-OECD countries, respond to temperature extremes.
  67. doi Socioeconomic inequalities in health in 22 European countries
    Johan P Mackenbach
    Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 358:2468-81. 2008
    Comparisons among countries can help to identify opportunities for the reduction of inequalities in health. We compared the magnitude of inequalities in mortality and self-assessed health among 22 countries in all parts of Europe.
  68. doi A cohort study relating urban green space with mortality in Ontario, Canada
    Paul J Villeneuve
    Population Studies Division, Health Canada, Ottawa, ON, Canada
    Environ Res 115:51-8. 2012
    ..There have been few evaluations of access to green space on mortality. This paper describes a cohort study of approximately 575,000 adults, 35 years of age and older, who resided in ..
  69. ncbi Trends in cancer mortality in China: an update
    P Guo
    Department of Preventive Medicine, Shantou University Medical College, Shantou, China
    Ann Oncol 23:2755-62. 2012
    Cancer deaths of China with the world population nearly a quarter will have a severe impact on global cancer trend and burden. The study aims to provide a comprehensive overview of long-term trends in cancer mortality in China.
  70. doi An updated report of the trends in cancer incidence and mortality in Japan
    Kota Katanoda
    Cancer Information Services and Surveillance Division, Center for Cancer Control and Information Services, National Cancer Center, 5 1 1 Tsukiji Chuo ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 43:492-507. 2013
    The analysis of cancer trends in Japan has only been sporadically reported. We present a comprehensive report on the trends in cancer incidence and mortality in Japan using the most recent population-based data.
  71. pmc Trends in age-specific coronary heart disease mortality in the European Union over three decades: 1980-2009
    Melanie Nichols
    British Heart Foundation Health Promotion Research Group, Department of Public Health, University of Oxford, Oxford OX3 7LF, UK
    Eur Heart J 34:3017-27. 2013
    Recent decades have seen very large declines in coronary heart disease (CHD) mortality across most of Europe, partly due to declines in risk factors such as smoking...
  72. ncbi Mortality benefits of influenza vaccination in elderly people: an ongoing controversy
    Lone Simonsen
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Lancet Infect Dis 7:658-66. 2007
    Influenza vaccination policy in most high-income countries attempts to reduce the mortality burden of influenza by targeting people aged at least 65 years for vaccination. However, the effectiveness of this strategy is under debate...
  73. ncbi Impact of influenza vaccination on seasonal mortality in the US elderly population
    Lone Simonsen
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 6613, USA
    Arch Intern Med 165:265-72. 2005
    Observational studies report that influenza vaccination reduces winter mortality risk from any cause by 50% among the elderly...
  74. doi Unemployment and mortality--a longitudinal prospective study on selection and causation in 49321 Swedish middle-aged men
    A Lundin
    Division of Occupational and Environmental Medicine, Department of Public Health Sciences, Karolinska Institutet, Norrbacka plan 5, 171 76 Stockholm, Sweden
    J Epidemiol Community Health 64:22-8. 2010
    Unemployment is associated with increased risk of mortality. It is, however, not clear to what extent this is causal, or whether other risk factors remain uncontrolled for...
  75. doi Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study
    Rudi G J Westendorp
    Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    J Am Geriatr Soc 57:1634-7. 2009
    To compare the risk of mortality of nonagenarian siblings with that of sporadic nonagenarians (not selected on having a nonagenarian sibling) and to compare the prevalence of morbidity in their offspring with that of the offsprings' ..
  76. pmc Effect of telehealth on use of secondary care and mortality: findings from the Whole System Demonstrator cluster randomised trial
    Adam Steventon
    The Nuffield Trust, London W1G 7LP, UK
    BMJ 344:e3874. 2012
    To assess the effect of home based telehealth interventions on the use of secondary healthcare and mortality.
  77. doi The public health effect of economic crises and alternative policy responses in Europe: an empirical analysis
    David Stuckler
    Department of Sociology, Oxford University, Oxford, UK
    Lancet 374:315-23. 2009
    ..We investigated how economic changes have affected mortality rates over the past three decades and identified how governments might reduce adverse effects.
  78. ncbi Explaining the decrease in U.S. deaths from coronary disease, 1980-2000
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 356:2388-98. 2007
    b>Mortality from coronary heart disease in the United States has decreased substantially in recent decades...
  79. doi Heat effects on mortality in 15 European cities
    Michela Baccini
    Department of Statistics, University of Florence, Italy
    Epidemiology 19:711-9. 2008
    Epidemiologic studies show that high temperatures are related to mortality, but little is known about the exposure-response function and the lagged effect of heat...
  80. ncbi Influence of exercise, walking, cycling, and overall nonexercise physical activity on mortality in Chinese women
    Charles E Matthews
    Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt Epidemiology Center, Vanderbilt University Medical School, Nashville, TN 37203 1738, USA
    Am J Epidemiol 165:1343-50. 2007
    ..walking, and cycling for transportation, as well as the effect of overall nonexercise physical activity, on mortality in the Shanghai Women's Health Study (1997-2004)...
  81. ncbi Effect of medication nonadherence on hospitalization and mortality among patients with diabetes mellitus
    P Michael Ho
    Department of Medicine, Denver Veterans Affairs Medical Center, CO, USA
    Arch Intern Med 166:1836-41. 2006
    Medication nonadherence may reduce the effectiveness of therapies. To our knowledge, the association between medication nonadherence and mortality remains unexplored outside the context of clinical trials.
  82. pmc Long-term ozone exposure and mortality
    Michael Jerrett
    Division of Environmental Health Sciences, School of Public Health, University of California, 710 University Hall, Berkeley, CA 94720, USA
    N Engl J Med 360:1085-95. 2009
    ..ozone to adverse health outcomes, the effect of long-term exposure to ozone on air pollution-related mortality remains uncertain...
  83. ncbi Caregiving as a risk factor for mortality: the Caregiver Health Effects Study
    R Schulz
    Department of Psychiatry and University Center for Social and Urban Research, University of Pittsburgh, PA 15260, USA
    JAMA 282:2215-9. 1999
    ..distress, the physical demands of caregiving, and biological vulnerabilities of older caregivers may compromise their physiological functioning and increase their risk for physical health problems, leading to increased mortality.
  84. ncbi Demography. Broken limits to life expectancy
    Jim Oeppen
    Cambridge Group for the History of Population and Social Structure, Cambridge University, Cambridge, CB2 3EN, UK
    Science 296:1029-31. 2002
  85. pmc Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995-2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data
    M P Coleman
    Cancer Research UK Cancer Survival Group, London School of Hygiene and Tropical Medicine, London, UK
    Lancet 377:127-38. 2011
    ..This is the first study in a programme to investigate international survival disparities, with the aim of informing health policy to raise standards and reduce inequalities in survival...
  86. doi Screen-based entertainment time, all-cause mortality, and cardiovascular events: population-based study with ongoing mortality and hospital events follow-up
    Emmanuel Stamatakis
    Department of Epidemiology and Public Health, University College London, United Kingdom
    J Am Coll Cardiol 57:292-9. 2011
    ..relationships of television viewing or other screen-based entertainment ("screen time") with all-cause mortality and clinically confirmed cardiovascular disease (CVD) events...
  87. pmc Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic review
    An Pan
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
    JAMA 306:1241-9. 2011
    ..Several studies have suggested that depression is associated with an increased risk of stroke; however, the results are inconsistent...
  88. doi Domains of physical activity and all-cause mortality: systematic review and dose-response meta-analysis of cohort studies
    Guenther Samitz
    Centre of Sports Science and University Sports, University of Vienna, Wien, Austria
    Int J Epidemiol 40:1382-400. 2011
    The dose-response relation between physical activity and all-cause mortality is not well defined at present...
  89. pmc Is self-rated health an independent index for mortality among older people in Indonesia?
    Nawi Ng
    Division of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umeå Centre for Global Health Research, Umea University, Umea, Sweden
    PLoS ONE 7:e35308. 2012
    Empirical studies on the association between self-rated health (SRH) and subsequent mortality are generally lacking in low- and middle-income countries...
  90. pmc The impact of antiretroviral therapy on adult mortality in rural Tanzania
    Milly Marston
    London School of Hygiene and Tropical Medicine, UK
    Trop Med Int Health 17:e58-65. 2012
    To describe the impact of antiretroviral therapy (ART) on mortality rates among adults participating in an HIV community cohort study in north-west Tanzania.
  91. pmc Long-term exposure to urban air pollution and mortality in a cohort of more than a million adults in Rome
    Giulia Cesaroni
    Department of Epidemiology, Lazio Regional Health Service, Rome, Italy
    Environ Health Perspect 121:324-31. 2013
    Few European studies have investigated the effects of long-term exposure to both fine particulate matter (≤ 2.5 µm; PM2.5) and nitrogen dioxide (NO2) on mortality.
  92. doi Temperature-mortality relationship in four subtropical Chinese cities: a time-series study using a distributed lag non-linear model
    Wei Wu
    Guangdong Provincial Institute of Public Health, Guangzhou, China
    Sci Total Environ 449:355-62. 2013
    Numerous studies have reported the association between ambient temperature and mortality. However, few multicity studies have been conducted in subtropical regions in developing countries...
  93. doi Vitamin D supplementation for prevention of mortality in adults
    Goran Bjelakovic
    Department of Internal Medicine, Medical Faculty, University of Nis, Zorana Djindjica 81, Nis, Serbia, 18000
    Cochrane Database Syst Rev 1:CD007470. 2014
    Available evidence on the effects of vitamin D on mortality has been inconclusive. In a recent systematic review, we found evidence that vitamin D3 may decrease mortality in mostly elderly women...
  94. pmc Has the impact of heat waves on mortality changed in France since the European heat wave of summer 2003? A study of the 2006 heat wave
    A Fouillet
    INSERM, U754, IFR69, Universite Paris Sud 11, Epidémiologie Environnementale des Cancers, Villejuif, France
    Int J Epidemiol 37:309-17. 2008
    ..In order to evaluate the effectiveness of those measures, the observed excess mortality during the 2006 heat wave was compared to the expected excess mortality.
  95. pmc Alternative Healthy Eating Index and mortality over 18 y of follow-up: results from the Whitehall II cohort
    Tasnime N Akbaraly
    Department of Epidemiology and Public Health, University College London, London, United Kingdom
    Am J Clin Nutr 94:247-53. 2011
    Indexes of diet quality have been shown to be associated with decreased risk of mortality in several countries...
  96. doi The impact of a Mediterranean diet and healthy lifestyle on premature mortality in men and women
    Piet A van den Brandt
    Department of Epidemiology, Schools for Oncology and Developmental Biology and Public Health and Primary Care, Maastricht University Medical Centre, Netherlands
    Am J Clin Nutr 94:913-20. 2011
    The Mediterranean diet has been associated with reduced mortality; few studies have investigated the combined impact of the Mediterranean diet with other modifiable lifestyle factors.
  97. doi What measure of temperature is the best predictor of mortality?
    A G Barnett
    School of Public Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Australia
    Environ Res 110:604-11. 2010
    Hot and cold temperatures significantly increase mortality rates around the world, but which measure of temperature is the best predictor of mortality is not known...
  98. pmc Prospective study of one million deaths in India: rationale, design, and validation results
    Prabhat Jha
    Centre for Global Health Research, Public Health Sciences, St Michael s Hospital, McLaughlin Centre for Molecular Medicine, University of Toronto, Toronto, Canada
    PLoS Med 3:e18. 2006
    ..We report here on the rationale, design, and implementation of the world's largest prospective study of the causes and correlates of mortality.
  99. doi Influence of individual and combined health behaviors on total and cause-specific mortality in men and women: the United Kingdom health and lifestyle survey
    Elisabeth Kvaavik
    Department of Nutrition, University of Oslo, PO Box 1046 Blindern, N 0316 Oslo, Norway
    Arch Intern Med 170:711-8. 2010
    Physical activity, diet, smoking, and alcohol consumption have been shown to be related to mortality. We examined prospectively the individual and combined influence of these risk factors on total and cause-specific mortality.
  100. pmc Excess winter mortality in Europe: a cross country analysis identifying key risk factors
    J D Healy
    Department of Environmental Studies, University College Dublin, Richview Campus, Dublin 14, Ireland
    J Epidemiol Community Health 57:784-9. 2003
    Much debate remains regarding why certain countries experience dramatically higher winter mortality. Potential causative factors other than cold exposure have rarely been analysed...
  101. doi Temperature extremes and health: impacts of climate variability and change in the United States
    Marie S O'Neill
    Department of Epidemiology and Environmental Health Dr Neill, University of Michigan School of Public Health, Ann Arbor, Mich, USA
    J Occup Environ Med 51:13-25. 2009
    We evaluated temperature-related morbidity and mortality for the 2007 U.S. national assessment on impacts of climate change and variability on human health.

Research Grants94

  1. Congenital and neonatal malaria in Mali
    Abdoulaye Djimde; Fiscal Year: 2006
    ..In the West African nation of Mali, malaria is indeed the lead killer disease. Nationwide, infant mortality rate is estimated to be 149 per thousand live births while the mortality rate for neonates (age 0-28 days) is ..
  2. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  3. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..Hence, limiting this injury is of paramount importance for reducing the morbidity and mortality associated with ischemic heart disease...
  4. Yasmin Wadia; Fiscal Year: 2014
    ..renal function or long term renal function via creatinine clearance and MAG3 nuclear renal scan and e) mortality. Efficacy will be determined by comparing treatment and controls with respect to the objective response rate ..
  5. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..or aneurysmal vascular changes is based upon watchful surveillance with potential high associated morbidity and mortality. Even with treatment, disease can progress and recur with cessation of treatment...
  6. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..blood donors and the screening of donated blood for various serological markers have significantly reduced the mortality and morbidity due to transfusion-associated infectious agents...
  7. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..Farmers were found to be at elevated risk for prostate cancer in a study of mortality in 24 states...
  8. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..Farmers were found to be at elevated risk for prostate cancer in a study of mortality in 24 states...
  9. Ian C Michelow; Fiscal Year: 2016
    ..Young children in malaria endemic areas of Africa have the highest mortality because of their immature immune systems...
  10. ASTHMA AND ALLERGIC DISEASE CENTER
    Thomas A Platts Mills; Fiscal Year: 2010
    ..In particular asthma has become an important cause of school absenteeism, hospitalization and mortality among populations living in poverty in the cities of the United States...
  11. Sogol Mostoufi-Moab; Fiscal Year: 2016
    ..As mortality continues to decline, the focus of clinical care has turned to the identification and prevention of treatment-..
  12. MERVYN N WEITZMANN; Fiscal Year: 2016
    ..fractures resulting from osteoporosis lead to significant health costs, morbidity, loss of mobility, and often mortality in aged individuals...
  13. Jill M Wecht; Fiscal Year: 2014
    ..disease risk in these individuals, although the prevalence of cardiovascular disease and attributable mortality appear to be greater than that encountered in the general population...
  14. Carole R Mendelson; Fiscal Year: 2016
    ..born infants can result in respiratory distress syndrome (RDS), the leading cause of neonatal morbidity and mortality in the U.S...
  15. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..MS generally causes cardiovascular disease (CVD), which is the leading cause of mortality and morbidity in the United States. Insulin resistance is a central component defining the MS...
  16. Noreen F Rossi; Fiscal Year: 2016
    ..without stenting in controlling arterial pressure, decreasing cardiac or renal events, or reducing morbidity and mortality remain unproven and controversial. Surgical intervention and inhibition of angiotensin II carry substantial risk...
  17. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..package PUBLIC HEALTH RELEVANCE: Project narrative: Dysregulation of body weight is associated with significant mortality in the United States and world wide...
  18. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..injury and hypovolemic circulatory collapse, multiple organ failure (MOF) is the most important contributor to mortality. Acute lung injury (ALI) precedes the development of MOF in 83% of cases, occurs in up to 37% of patients ..
  19. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..S. Cardiovascular disease is the leading cause of morbidity and mortality in diabetes...
  20. Emilio B Gonzalez; Fiscal Year: 2014
    ..Thrombosis is an important cause of morbidity and mortality in APS and SLE patients with aPL Abs. APL Abs antibodies recognize domain I (DI) of 22glycoprotein I (22GPI)...
  21. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    ..for cancer and death ascertainment to determine if the screening regimen results in reduced disease-specific mortality. Baseline information including demographic characteristics, known risk factors for the cancers under study, and ..
  22. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    ..for cancer and death ascertainment to determine if the screening regimen results in reduced disease-specific mortality. Baseline information including demographic characteristics, known risk factors for the cancers under study, and ..
  23. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..to alcoholic heart disease in women is exacerbated by evidence indicating that post-menopausal women have higher mortality rates after myocardial infarction vs aged men, and it is unclear whether the effects of aging and estrogen (E2) ..
  24. A Hybrid PARP Inhibitor and Redox Catalyst for Lung Transplantation
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..shunt, 2) duration of mechanical ventilation, 3) length of hospitalization, and 4) all-cause 30 and 365 day mortality. PUBLIC HEALTH RELEVANCE: Ischemia-reperfusion injury is a major medical complication following lung ..
  25. Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for Endotoxemia
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Septic shock resulting from acute bowel perforation and infection is a major cause of mortality. At present, there is no approved therapy for this condition and prognosis is uniformly poor...
  26. Patrice G Guyenet; Fiscal Year: 2015
    ..syndrome and is a probable mechanism of sudden infant death syndrome (SIDS), the main cause of infant mortality in industrialized countries (5 per thousand live births)...
  27. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..in long-term adverse effects on cardiovascular risk, there is likely to be an increase in veteran morbidity and mortality due to cardiovascular disease...
  28. BRIAN JAMES MCMAHON; Fiscal Year: 2016
    ..non- alcoholic fatty liver disease and autoimmune hepatitis have been shown to cause substantial morbidity and mortality among Alaska Native persons...
  29. CLIFFORD RUSSELL GREYSON; Fiscal Year: 2016
    ..ventricular (RV) contractile failure from acute pulmonary hypertension is an important cause of morbidity and mortality in conditions such as massive pulmonary embolism, hypoxic pulmonary vasoconstriction, and following ..
  30. ENEIQUE A MESRI; Fiscal Year: 2016
    ..advanced KS generally characterized as an advanced disseminated cancer with increased morbidity and mortality is treated with systemic chemotherapy...
  31. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..by applicant): Lung ischemia-reperfusion injury (IRI) is an acute lung injury that contributes to morbidity and mortality following lung transplantation (LTX)...
  32. Jian Min Yuan; Fiscal Year: 2014
    ..The findings of the proposed study will have great impact on reducing incidence and mortality of lung and liver cancers in humans.
  33. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..Reducing infant mortality is one of the Millennium Development Goals, so the public health importance of understanding and minimizing ..
  34. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..1436C?T sequence variant also have the highest rates of infant mortality in Alaska. Based on these observations the investigators hypothesize that homozygosity for the c...
  35. Craig T Morita; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): In the United States and throughout the world, cancer incidence and mortality has increased dramatically in both developed and developing nations. Cancer causes ~13% of human deaths with 7...
  36. The role of Fli1 in T cell function and the pathogenesis of lupus
    Tamara K Nowling; Fiscal Year: 2011
    ..It also is 4-5 times more common in African Americans and Hispanics than Caucasians, and morbidity and mortality are greater in African Americans/Hispanics with lupus...
  37. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..functionality leading to a decrease in quality of life, poor response to anti-cancer therapies and increased mortality. Currently there is no effective way to treat cachexia...
  38. Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseases
    Robert M Weiss; Fiscal Year: 2010
    ..deacetylase inhibitors (HDACIs) more effectively reduce tumor burden, the time to onset, rate of occurrence and mortality compared to individual encapsulated siRNAs in a nitrosamine induced bladder cancer model...
  39. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    Coronary artery disease (CAD) is the most common cause of morbidity and mortality worldwide. A cluster of metabolic phenotypes known as metabolic syndrome has been established as a major risk factor for CAD...
  40. Hybrid Optical/Doppler Imaging of Ischemia in NEC - a multicenter trial
    David A Benaron; Fiscal Year: 2010
    ..The mortality of NEC ranges from 10% to 50%, approaching 100% for neonates with severe forms of the disease characterized by ..
  41. Robert T Means; Fiscal Year: 2014
    ..PUBLIC HEALTH RELEVANCE: Anemia is a major contributor to morbidity and mortality in chronically ill patients, and the anemia of chronic disease (ACD) is the major etiology of this anemia...
  42. Junxuan Lu; Fiscal Year: 2014
    ..has become recognized as a plausible and cost-effective alternative approach to reduce the morbidity and mortality of PCa...
  43. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..a person's risk for kidney disease, stroke, coronary artery disease, congestive heart failure and overall mortality. Reducing blood pressure to normal levels decreases the morbidity and mortality associated with hypertension, ..
  44. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2012
    ..In contrast, GI radiation syndrome remains poorly treatable resulting in significant mortality and reduced quality of life for survivors...
  45. Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret Model
    Zoe Stewart; Fiscal Year: 2013
    ..However, CF ferrets have high perinatal mortality from abnormal intestinal and pancreatic function, altered glucose and lipid metabolism, and lung infections...
  46. Charlotte Cunningham-Rundles; Fiscal Year: 2015
    ..primary immune defects are found in humans of all ages, leading to characteristic complications and significant mortality. While there have been amazing advances in the understanding many conditions, the more prevalent immune defects ..
  47. Shervin Assassi; Fiscal Year: 2014
    ..Proposed Research: SSc is associated with substantial morbidity and mortality. Pulmonary involvement is the primary cause of SSc-related death...
  48. Community Participation Research of Breastfeeding Disparities in African American
    Tamar Ringel Kulka; Fiscal Year: 2009
    ..and when they do breastfeed, it is for significantly shorter durations on average, experience a disproportionate mortality from the same illnesses that are known to be reduced if one breastfeeds...
  49. SPEAKER TRAVEL AND SCIENTIFIC SESSION SUPPORT FOR THE TERATOLOGY SOCIETY 50TH
    Christina Chambers; Fiscal Year: 2011
    ..Birth defects constitute a major public health concern in the world today and are the leading cause of infant mortality in the United States...
  50. PAUL CAMILLE TUMEH; Fiscal Year: 2015
    ..The direct cost associated with this significant morbidity and mortality has been estimated to be 1.4 billion US dollars annually...
  51. Laura L Dugan; Fiscal Year: 2014
    ..associated with, or predict, enhanced risk of frailty, loss of muscle mass and strength, disability, and early mortality, as well as acute and chronic cognitive decline, development of Alzheimer's disease, and drug- and stress-..
  52. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..mainly from fish-oil) based upon purported effects that include: reduction in cardiovascular morbidity and mortality, reduction in cerebrovascular disease and stroke, preservation of vision, and slowing of cognitive decline ..
  53. Sharon M Moe; Fiscal Year: 2014
    ..is an increased incidence of low bone mass and fractures and coronary artery calcification and cardiovascular mortality compared to the general population...
  54. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
    ..Project Narrative In the United States, heart failure affects more than 4 million people, who display 6-year mortality rates of greater than 65% once failure develops...
  55. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..incidence has declined from about 60 per 100,000 in 1975 to ~ 50 per 100,000 in 2004, and the decrease in USA mortality has recently accelerated (i.e...
  56. Thalachallour Mohanakumar; Fiscal Year: 2015
    ..diagnosed as Bronchiolitis obliterans Syndrome (BOS), is the most significant long term cause of morbidity and mortality following human lung transplantation (LTx)...
  57. Rinn Song; Fiscal Year: 2016
    ..PUBLIC HEALTH RELEVANCE: Tuberculosis is a leading cause of childhood morbidity and mortality worldwide...
  58. REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
    Girija G Konduri; Fiscal Year: 2013
    ..The affected infants are hypoxemic and have increased risks of mortality and long-term disabilities...
  59. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hypertension (HTN) is a leading cause of morbidity and mortality worldwide, contributing to cardiovascular disease, stroke, and end stage kidney disease...
  60. William M Nauseef; Fiscal Year: 2016
    ..93 per 1,000 discharges in 2000 to 30.59 in 2007 ( 14%). Consequently, the attendant rises in morbidity and mortality present a significant challenge to our health care system...
  61. Identification and Analysis of Flavivirus Protease and RNA Helicase Inhibitors
    Radhakrishnan Padmanabhan; Fiscal Year: 2009
    ..West Nile virus (WNV) and Dengue (DEN1-4) viruses that cause serious illnesses with considerable morbidity and mortality. These viruses, in addition to flu-like symptoms, can cause hemorrhagic fevers (YFV and DEN) or encephalitis and/..
  62. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    Liver damage and failure due to various forms of hepatic injury is a significant source of overall morbidity and mortality in the US and worldwide...
  63. Yaya Wang; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Autoimmune diseases in aggregate represent a leading cause of morbidity and mortality. Despite apparent clinical heterogeneity among human autoimmune diseases, the potential for shared pathogenetic ..
  64. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    ..has been estimated that >750,000 cases of severe sepsis occur annually in the United States, with a hospital mortality rate of ~35%. This number continues to grow annually...
  65. Prevention of heart failure and death by sphingolipids: outcomes and mechanisms.
    JOEL KARLINER; Fiscal Year: 2009
    ..Summary/Abstract Myocardial infarction and resulting congestive heart failure remain the number one cause of mortality in the United States and affect the aging veteran population particularly...
  66. Severe H1N1 Influenza Infection During Pregnancy: Pathophysiologic Mechanisms
    Mark Phillippe; Fiscal Year: 2010
    ..Although the early phase of this new pandemic has been associated with mild morbidity and low mortality, a significant numbers of patients have died in the U.S. and world-wide. The second reported death in the U.S...
  67. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..and attention-deficit/hyperactivity disorder (ADHD) are amongst the most significant causes of morbidity and mortality in the USA. Although treatments for these disorders are available they are less than adequate...
  68. Biochemical, Biomechanical & Morphological Properties of Quantitative Ultrasound
    Barbara L McFarlin; Fiscal Year: 2010
    ..In the United States, prematurity is the second leading cause of infant mortality and the leading cause of infant mortality for African Americans...
  69. PROJECTED HEAT WAVE MAGNITUDES AND PUBLIC HEALTH IMPACTS
    Helene G Margolis; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Background: Virtually all heat-related morbidity/mortality (HRMM) is preventable, yet extreme heat events (EHE) remain the leading cause of weather-related deaths in the United States...
  70. RESPIRATORY DISEASES/BSI STUDY
    Shahin Lockman; Fiscal Year: 2004
    ..in Botswana, as well as studies of other aspects of HIV epidemiology and infant infectious disease morbidity and mortality. The candidate plans to pursue an independent career in HIV and TB epidemiology and clinical trials...
  71. FLORIDA FIREFIGHTER CANCER INCIDENCE AND MORTALITY
    Lora Fleming; Fiscal Year: 2001
    ..Excess mortality for cancer of the lung, kidney and ureter, rectum and colon, and skin has also been reported...
  72. A Novel Therapeutic Approach for Liver Injury
    Xiaoling Qiang; Fiscal Year: 2010
    ..Hepatic I/R contributes significantly to multiple organ failure and mortality. Although various modalities and substances have been studied to reduce hepatic I/R-induced mortality, none have ..
  73. The Effects of Neonatal Intensive Care Deregionalization on Treatment and Infant
    SETH FREEDMAN; Fiscal Year: 2009
    ..in the location of high-risk infant deliveries towards mid-level hospitals and up to 100% higher risk adjusted mortality rates for high-risk infants born in mid-level hospitals compared to high-level hospitals...
  74. MORTALITY BY RACE AMONG LOW BIRTH WEIGHT INFANTS
    Robert Michielutte; Fiscal Year: 1990
    The primary goal of the proposed study is to examine the relationship between race and infant mortality in the context of a general model of risk factors for infant mortality...
  75. National Lung Screening Trial (NLST)
    Cheryl Robinson; Fiscal Year: 2009
    ..of screening modalities such as chest x-ray and sputum cytology have not demonstrated any impact on lung cancer mortality. Therefore, without effective screening or substantive improvements in effective therapies little progress has ..
  76. The Shape of Income and Mortality
    George Kaplan; Fiscal Year: 2009
    ..For example, according to a MEDLINE search, well over 700 articles on the association between income and mortality have appeared since 1990, not including analyses that only included income as an adjustment variable...
  77. KANGAROO MOTHER CARE TO PREVENT INFANT MORTALITY
    Nancy Sloan; Fiscal Year: 2001
    ..at greater risk of life-threatening respiratory and gastrointestinal conditions that account for much of the mortality in early infancy...
  78. Disparities in CHD in the Jackson Heart Study
    Mario Sims; Fiscal Year: 2010
    ..CHD is the leading cause of CVD mortality in America, and Mississippi has the highest overall CVD mortality rate in the nation...
  79. RACE AND ETHNIC DIFFERENCES IN U.S. BIRTH OUTCOMES
    Michael Grossman; Fiscal Year: 1990
    ..and the source of differences in these outcomes. The outcomes pertain to birthweight, low birthweight, neonatal mortality, and birthweight- and cause-specific postneonatal mortality...
  80. Spatial, Temporal, Social Disparities in Breast Cancer
    Mario Schootman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Screening for breast cancer reduces mortality. Following the implementation of screening programs, European studies have shown that the incidence of early-stage and in situ breast cancers increased ..
  81. HEART RATE RECOVERY AND MORTALITY
    Michael Lauer; Fiscal Year: 2002
    ..risk of death, our hypothesis is that an impaired heart-rate recovery is a powerful and independent predictor of mortality. Our group recently published the first report linking heart-rate recovery to long-term mortality in the New ..
  82. National Lung Study Trial
    Douglas Reding; Fiscal Year: 2009
    ..of screening modalities such as chest x-ray and sputum cytology have not demonstrated any impact on lung cancer mortality. Therefore, without effective screening or substantive improvements in effective therapies little progress has ..
  83. EFFECTS OF AMBIENT AIR POLLUTANTS ON ANNUAL MORTALITY
    George Thurston; Fiscal Year: 2001
    ..6-cities and American Cancer Society) showed significant excess annual total, cardiopulmonary, and lung cancer mortality in proportion to annual average fine particle mass concentration (PM2.5) and/or sulfate aerosol concentration...
  84. OCCUPATIONAL MORTALITY--CALIFORNIA HISPANIC POPULATION
    James Beaumont; Fiscal Year: 1993
    There has been little study of occupational mortality in Hispanic populations, despite evidence that Hispanics have greater potential for hazardous exposures in some occupations, and evidence that Hispanics have unusually high rates for ..