morbidity

Summary

Summary: The proportion of patients with a particular disease during a given year per given unit of population.

Top Publications

  1. ncbi Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa
    Marieke J van der Werf
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Acta Trop 86:125-39. 2003
  2. ncbi Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    Geoffrey A Block
    Denver Nephrology Associates, Denver Colorado, USA
    J Am Soc Nephrol 15:2208-18. 2004
  3. doi Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study
    Jean Francois Trape
    Research Unit on Emerging Infectious and Tropical Diseases, Institut de Recherche pour le Developpement, Dakar, Senegal
    Lancet Infect Dis 11:925-32. 2011
  4. pmc Ambient temperature and morbidity: a review of epidemiological evidence
    Xiaofang Ye
    School of Public Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    Environ Health Perspect 120:19-28. 2012
  5. doi Morbidity is related to a green living environment
    J Maas
    EMGO Institute, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Epidemiol Community Health 63:967-73. 2009
  6. doi High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European cities
    Paola Michelozzi
    Department of Epidemiology Local Health Authority Rome E, Rome, Italy
    Am J Respir Crit Care Med 179:383-9. 2009
  7. doi Socioeconomic inequalities in health in 22 European countries
    Johan P Mackenbach
    Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 358:2468-81. 2008
  8. doi Ethnic disparity in severe acute maternal morbidity: a nationwide cohort study in the Netherlands
    Joost J Zwart
    Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Public Health 21:229-34. 2011
  9. pmc Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span
    Stacy L Andersen
    New England Centenarian Study, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 67:395-405. 2012
  10. pmc From planning to practice: building the national network for the Surveillance of Severe Maternal Morbidity
    Samira M Haddad
    Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, Brazil
    BMC Public Health 11:283. 2011

Research Grants

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
  2. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
  3. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
  4. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
  5. Yasmin Wadia; Fiscal Year: 2014
  6. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
  7. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
  8. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
  9. MERVYN N WEITZMANN; Fiscal Year: 2016
  10. Carole R Mendelson; Fiscal Year: 2016

Detail Information

Publications512 found, 100 shown here

  1. ncbi Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa
    Marieke J van der Werf
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Acta Trop 86:125-39. 2003
    ..We explored the relationship between the presence of schistosome infection and clinical morbidity, in order to estimate numbers of individuals with disease-specific morbidity for Schistosoma haematobium and ..
  2. ncbi Mineral metabolism, mortality, and morbidity in maintenance hemodialysis
    Geoffrey A Block
    Denver Nephrology Associates, Denver Colorado, USA
    J Am Soc Nephrol 15:2208-18. 2004
    ..For determining associations among disorders of mineral metabolism, mortality, and morbidity in hemodialysis patients, data on 40,538 hemodialysis patients with at least one determination of serum ..
  3. doi Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study
    Jean Francois Trape
    Research Unit on Emerging Infectious and Tropical Diseases, Institut de Recherche pour le Developpement, Dakar, Senegal
    Lancet Infect Dis 11:925-32. 2011
    ..Our aim was to assess the effect of these policies on malaria morbidity, mosquito populations, and asymptomatic infections in a west African rural population.
  4. pmc Ambient temperature and morbidity: a review of epidemiological evidence
    Xiaofang Ye
    School of Public Health and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
    Environ Health Perspect 120:19-28. 2012
    In this paper, we review the epidemiological evidence on the relationship between ambient temperature and morbidity. We assessed the methodological issues in previous studies and proposed future research directions.
  5. doi Morbidity is related to a green living environment
    J Maas
    EMGO Institute, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Epidemiol Community Health 63:967-73. 2009
    ..This study investigates whether physician-assessed morbidity is also related to green space in people's living environment.
  6. doi High temperature and hospitalizations for cardiovascular and respiratory causes in 12 European cities
    Paola Michelozzi
    Department of Epidemiology Local Health Authority Rome E, Rome, Italy
    Am J Respir Crit Care Med 179:383-9. 2009
    Episode analyses of heat waves have documented a comparatively higher impact on mortality than on morbidity (hospital admissions) in European cities. The evidence from daily time series studies is scarce and inconsistent.
  7. doi Socioeconomic inequalities in health in 22 European countries
    Johan P Mackenbach
    Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 358:2468-81. 2008
    ..Comparisons among countries can help to identify opportunities for the reduction of inequalities in health. We compared the magnitude of inequalities in mortality and self-assessed health among 22 countries in all parts of Europe...
  8. doi Ethnic disparity in severe acute maternal morbidity: a nationwide cohort study in the Netherlands
    Joost J Zwart
    Department of Obstetrics, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Public Health 21:229-34. 2011
    ..Our aim was to assess these differences in a large cohort of women having experienced severe acute maternal morbidity (SAMM) during pregnancy, delivery and puerperium.
  9. pmc Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span
    Stacy L Andersen
    New England Centenarian Study, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Gerontol A Biol Sci Med Sci 67:395-405. 2012
    We analyze the relationship between age of survival, morbidity, and disability among centenarians (age 100-104 years), semisupercentenarians (age 105-109 years), and supercentenarians (age 110-119 years)...
  10. pmc From planning to practice: building the national network for the Surveillance of Severe Maternal Morbidity
    Samira M Haddad
    Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Campinas, Brazil
    BMC Public Health 11:283. 2011
    ..other hand, in developed regions, maternal death is a relatively rare event compared to the number of cases of morbidity; hence studying maternal morbidity has become more relevant...
  11. doi Factors influencing in-hospital mortality and morbidity in patients treated on a stroke unit
    Hans Christian Koennecke
    Department of Neurology, Vivantes Klinikum im Friedrichshain, Berlin, Germany
    Neurology 77:965-72. 2011
    To determine the extent that demographics, clinical characteristics, comorbidities, and complications contribute to the risk of in-hospital mortality and morbidity in acute stroke.
  12. doi Mortality and neonatal morbidity among infants 501 to 1500 grams from 2000 to 2009
    Jeffrey D Horbar
    Department of Pediatrics, University of Vermont, Burlington, Vermont 05401, USA
    Pediatrics 129:1019-26. 2012
    ..To identify changes in mortality and neonatal morbidities for infants with birth weight 501 to 1500 g born from 2000 to 2009...
  13. doi High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections
    N Lee
    Department of Medicine and Therapeutics
    Clin Infect Dis 57:1069-77. 2013
    ..Better understanding of complications and outcomes of adults hospitalized with respiratory syncytial virus (RSV) infection is necessary...
  14. pmc Evaluation of the optimal recall period for disease symptoms in home-based morbidity surveillance in rural and urban Kenya
    Daniel R Feikin
    International Emerging Infections Program, Kenya, and Centers for Disease Control and Prevention, Nairobi and Kisumu, Kenya
    Int J Epidemiol 39:450-8. 2010
    ..In African settings with poor access to health care, surveillance and surveys of disease burden are often done through home visits. The optimal recall period to capture data on symptoms and health utilization is unknown...
  15. pmc Breastfeeding and the risk for diarrhea morbidity and mortality
    Laura M Lamberti
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    BMC Public Health 11:S15. 2011
    ..0-5 months of age and no breastfeeding among children 6-23 months of age are associated with increased diarrhea morbidity and mortality in developing countries...
  16. pmc Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic review
    An Pan
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
    JAMA 306:1241-9. 2011
    ..Several studies have suggested that depression is associated with an increased risk of stroke; however, the results are inconsistent...
  17. ncbi Does the relationship between waist circumference, morbidity and mortality depend on measurement protocol for waist circumference?
    R Ross
    School of Kinesiology and Health Studies, Queen s University, Kingston, ON, Canada
    Obes Rev 9:312-25. 2008
    ..of 120 studies (236 samples) to determine whether measurement protocol influenced the relationship of WC with morbidity of cardiovascular disease (CVD) and diabetes and with mortality from all causes and from CVD...
  18. pmc Effect of preventive supplementation with ready-to-use therapeutic food on the nutritional status, mortality, and morbidity of children aged 6 to 60 months in Niger: a cluster randomized trial
    Sheila Isanaka
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    JAMA 301:277-85. 2009
    ..Ready-to-use therapeutic foods (RUTFs) are an important component of effective outpatient treatment of severe wasting. However, their effectiveness in the population-based prevention of moderate and severe wasting has not been evaluated...
  19. pmc Strategies to reduce early morbidity and mortality in adults receiving antiretroviral therapy in resource-limited settings
    Stephen D Lawn
    Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
    Curr Opin HIV AIDS 5:18-26. 2010
    We review recently published literature concerning early morbidity and mortality during antiretroviral therapy (ART) among patients in resource-limited settings...
  20. ncbi Maternal Trypanosoma cruzi infection, pregnancy outcome, morbidity, and mortality of congenitally infected and non-infected newborns in Bolivia
    Faustino Torrico
    Centro Universitario de Medicina Tropical, Facultad de Medicina, Universidad Mayor de San Simon, Casilla, Cochabamba, Bolivia
    Am J Trop Med Hyg 70:201-9. 2004
    ..the decrease in poverty that has occurred in Bolivia between both surveys might have contributed to reduce the morbidity and mortality, but not the transmission rate of T...
  21. doi Effects of in utero arsenic exposure on child immunity and morbidity in rural Bangladesh
    Rubhana Raqib
    International Centre for Diarrhoeal Disease Research, Bangladesh ICDDR, B, Dhaka, Bangladesh
    Toxicol Lett 185:197-202. 2009
    ..effects of arsenic on immunity, we evaluated the impact of in utero exposure on infant immune parameters and morbidity in a pilot study...
  22. doi The prevalence of maternal near miss: a systematic review
    O Tuncalp
    Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    BJOG 119:653-61. 2012
    Severe maternal morbidity or 'near miss' is a promising indicator to improve quality of obstetric care.
  23. pmc Impact of malaria at the end of pregnancy on infant mortality and morbidity
    Azucena Bardaji
    Barcelona Centre for International Health Research and Department of Pathology, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Spain
    J Infect Dis 203:691-9. 2011
    There is some consensus that malaria in pregnancy may negatively affect infant's mortality and malaria morbidity, but there is less evidence concerning the factors involved.
  24. doi Self-reported sleep duration, all-cause mortality, cardiovascular mortality and morbidity in Finland
    Erkki Kronholm
    National Institute for Health and Welfare, Department of Chronic Disease Prevention, Turku, Finland
    Sleep Med 12:215-21. 2011
    ..Findings on cardiovascular (CVD) mortality and morbidity are inconsistent...
  25. ncbi Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Suite 301, Honolulu, HI 96813, USA
    Ann N Y Acad Sci 1114:434-55. 2007
    ..This study lends epidemiologic support for phenotypic benefits of CR in humans and is consistent with the well-known literature on animals with regard to CR phenotypes and healthy aging...
  26. pmc Differential expression of var gene groups is associated with morbidity caused by Plasmodium falciparum infection in Tanzanian children
    Matthias Rottmann
    Swiss Tropical Institute, Socinstrasse 57, CH 4002 Basel, Switzerland
    Infect Immun 74:3904-11. 2006
    ..These results suggest that substantial and systematic differences in var gene expression exist between different clinical presentations...
  27. pmc Rapid decrease of malaria morbidity following the introduction of community-based monitoring in a rural area of central Vietnam
    Ngo Duc Thang
    National Institute of Malariology, Parasitology and Entomology, Tu Liem district, Hanoi, Vietnam
    Malar J 8:3. 2009
    ..The evolution of malaria prevalence and incidence over two and half years in a rural area of central Vietnam, after the introduction of community-based monitoring of malaria cases, is presented...
  28. pmc Morbidity from malaria in children in the year after they had received intermittent preventive treatment of malaria: a randomised trial
    Amadou T Konate
    Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
    PLoS ONE 6:e23391. 2011
    Interventions that reduce exposure to malaria infection may lead to delayed malaria morbidity and mortality...
  29. pmc Racial disparities in health status: a comparison of the morbidity among American Indian and U.S. adults with diabetes
    Joan O'Connell
    Centers for American Indian and Alaska Native Health, Colorado School of Public Health, University of Colorado Denver, Denver, Colorado, USA
    Diabetes Care 33:1463-70. 2010
    American Indians and Alaska Natives are 2.3 times more likely to have diabetes than are individuals in the U.S. general population. The objective of this study was to compare morbidity among American Indian and U.S. adults with diabetes.
  30. ncbi Cytoreductive surgery followed by intraperitoneal hyperthermic perfusion: analysis of morbidity and mortality in 209 peritoneal surface malignancies treated with closed abdomen technique
    Shigeki Kusamura
    Department of Surgery, National Cancer Institute of Milan, Milan, Italy
    Cancer 106:1144-53. 2006
    The purpose of this prospective Phase II study was to analyze morbidity and mortality of cytoreductive surgery (CRS) and intraperitoneal hyperthermic perfusion (IPHP) in the treatment of peritoneal surface malignancies.
  31. ncbi Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality
    Alexander T Cohen
    Vascular Medicine, Department of Surgery, King s College Hospital, London, SE5 9RS, UK
    Thromb Haemost 98:756-64. 2007
    ..Given the availability of effective VTE prophylaxis, many of these events and deaths could have been prevented. These results have important implications for the allocation of healthcare resources...
  32. pmc Intensity-modulated radiation therapy, proton therapy, or conformal radiation therapy and morbidity and disease control in localized prostate cancer
    Nathan C Sheets
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, NC, USA
    JAMA 307:1611-20. 2012
    ..There has been rapid adoption of newer radiation treatments such as intensity-modulated radiation therapy (IMRT) and proton therapy despite greater cost and limited demonstrated benefit compared with previous technologies...
  33. pmc Quantifying disability: data, methods and results
    C J Murray
    Harvard Center for Population and Development Studies, Cambridge, MA 02138
    Bull World Health Organ 72:481-94. 1994
    ..The results should be useful to those concerned with planning health services for the disabled and, more particularly, with determining policies to prevent the underlying conditions which give rise to serious disabling sequelae...
  34. ncbi The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis
    M Isabel T D Correia
    Department of Surgery, Faculdade de Medicina da, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Clin Nutr 22:235-9. 2003
    ..The purpose of this study was to correlate the nutritional status of hospitalized patients with their morbidity, mortality, length of hospital stay and costs...
  35. doi Health-seeking patterns among participants of population-based morbidity surveillance in rural western Kenya: implications for calculating disease rates
    Godfrey Bigogo
    Center for Global Health Research, Kenya Medical Research Institute, PO Box 1578 40100, Kisumu, Kenya
    Int J Infect Dis 14:e967-73. 2010
    ..We describe temporal patterns in health care seeking by syndrome as part of population-based morbidity surveillance in rural western Kenya.
  36. pmc Intestinal schistosomiasis in mothers and young children in Uganda: investigation of field-applicable markers of bowel morbidity
    Martha Betson
    Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, United Kingdom
    Am J Trop Med Hyg 83:1048-55. 2010
    ..at a national level in sub-Saharan Africa, there is a need for field-applicable markers to measure morbidity associated with this disease...
  37. ncbi Mortality and morbidity of surgery for unruptured intracranial aneurysms: a meta-analysis
    T W Raaymakers
    Department of Neurology, Academic Hospital Utrecht, The Netherlands
    Stroke 29:1531-8. 1998
    ..Elective surgery requires reliable data on its risks. Therefore, we performed a meta-analysis on the mortality and morbidity of surgery for unruptured intracranial aneurysms.
  38. ncbi The continuum of maternal morbidity and mortality: factors associated with severity
    Stacie E Geller
    Department of Obstetrics and Gynecology, College of Medicine, University of Illinois at Chicago, 60612, USA
    Am J Obstet Gynecol 191:939-44. 2004
    The goal of this study was to examine whether sociodemographic, clinical, and other service-related factors, as well as preventability issues affect a woman's progression along the continuum of morbidity and mortality.
  39. ncbi Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial
    D S Echt
    CAST Coordinating Center, Seattle, WA 98105
    N Engl J Med 324:781-8. 1991
    ..The use of encainide and flecainide was discontinued because of excess mortality. We examined the mortality and morbidity after randomization to encainide or flecainide or their respective placebo.
  40. ncbi Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial. Optimal Trial in Myocardial Infarction with Angiotensin II Antagonist Losartan
    Kenneth Dickstein
    University of Bergen, Cardiology Division, Central Hospital in Rogaland, 4011 Stavanger, Norway
    Lancet 360:752-60. 2002
    ACE inhibitors attenuate the detrimental effects of angiotensin II, and improve survival and reduce morbidity in patients with acute myocardial infarction and evidence of heart failure or left-ventricular dysfunction...
  41. pmc Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study
    Catherine L Dent
    Department of Cardiology, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, 3333 Burnet Ave, Cincinnati, Ohio 45229, USA
    Crit Care 11:R127. 2007
    ..In this study we tested whether a point-of-care NGAL device can predict AKI after CPB in a larger cohort...
  42. pmc Malaria morbidity in Papua Indonesia, an area with multidrug resistant Plasmodium vivax and Plasmodium falciparum
    Muhammad Karyana
    International Health Division, Menzies School of Health Research, Darwin, Australia
    Malar J 7:148. 2008
    ..Multidrug resistance has emerged to both Plasmodium vivax and Plasmodium falciparum and yet the comparative epidemiology of these infections is poorly defined...
  43. ncbi Postoperative mortality and morbidity in French patients undergoing colorectal surgery: results of a prospective multicenter study
    Arnaud Alves
    Department of Digestive Surgery, Hopital Lariboisiere, 2 rue Ambroise Pare, 75475 Paris Cedex 10, France
    Arch Surg 140:278-83, discussion 284. 2005
    Better knowledge of independent risk factors might decrease mortality and morbidity rates following colorectal surgery.
  44. doi A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial
    Ulrika Gillespie
    Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
    Arch Intern Med 169:894-900. 2009
    ..The objective of this study was to investigate the effectiveness of interventions performed by ward-based pharmacists in reducing morbidity and use of hospital care among older patients.
  45. doi Major elective joint replacement surgery: socioeconomic variations in surgical risk, postoperative morbidity and length of stay
    Jennifer Hollowell
    Department of Epidemiology and Public Health, University College London, London, UK
    J Eval Clin Pract 16:529-38. 2010
    ..Our aim was to examine associations between deprivation and aspects of the inpatient episode for patients undergoing these procedures...
  46. doi The effects of extreme heat on human mortality and morbidity in Australia: implications for public health
    Peng Bi
    The University of Adelaide, Australia
    Asia Pac J Public Health 23:27S-36. 2011
    ..Consequently, in the absence of adaptation, the associated mortality and morbidity are expected to increase in a warming climate, particularly within the vulnerable populations of the elderly, ..
  47. doi Mental well-being and mental illness: findings from the Adult Psychiatric Morbidity Survey for England 2007
    Scott Weich
    Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
    Br J Psychiatry 199:23-8. 2011
    ..Mental well-being underpins many aspects of health and social functioning, and is economically important...
  48. ncbi Compression or expansion of morbidity? Trends in healthy-life expectancy in the elderly Austrian population between 1978 and 1998
    G Doblhammer
    Max Planck Institute for Demographic Research, Rostock, Germany
    Soc Sci Med 52:385-91. 2001
    The aim of our study is to test the theories of compression or expansion of morbidity on the basis of data on the elderly population of Austria. Our data come from four microcensus surveys for the years 1978, 1983, 1991, and 1998...
  49. ncbi Spatial analysis of risk factors for childhood morbidity in Nigeria
    Ngianga Bakwin Kandala
    Clinical Sciences Research Institute, Warwick Medical School, Coventry, United Kingdom
    Am J Trop Med Hyg 77:770-9. 2007
    ..Our maps are a novel and relevant tool to help local governments to improve health-care interventions and achieve Millennium Development Goals (MDG4)...
  50. doi Severe acute maternal morbidity in high-income countries
    Jos van Roosmalen
    Department of Obstetrics, Leiden University Medical Centre, The Netherlands
    Best Pract Res Clin Obstet Gynaecol 23:297-304. 2009
    ..in high income countries has become low in recent years and therefore analysis of severe acute maternal morbidity has been added to confidential enquiries into the causes of maternal deaths...
  51. pmc A diagnostic challenge for Schistosomiasis japonica in China: consequences on praziquantel-based morbidity control
    Yi biao Zhou
    Department of Epidemiology, School of Public Health, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
    Parasit Vectors 4:194. 2011
    ..Hence, a search for a diagnostic approach, which delivers these characteristics, is essential and should be given high priority...
  52. pmc Differences in Acinetobacter baumannii strains and host innate immune response determine morbidity and mortality in experimental pneumonia
    Anna de Breij
    Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 7:e30673. 2012
    ..baumannii strains and an A. junii strain and at several days morbidity, mortality, bacterial counts, airway inflammation, and chemo- and cytokine production in lungs and blood were ..
  53. doi General health checks in adults for reducing morbidity and mortality from disease
    Lasse T Krogsbøll
    The Nordic Cochrane Centre, Rigshospitalet, Copenhagen, Denmark
    Cochrane Database Syst Rev 10:CD009009. 2012
    ..These aim to detect disease and risk factors for disease with the purpose of reducing morbidity and mortality...
  54. pmc Self-rated health and morbidity onset among late midlife U.S. adults
    Kenzie Latham
    Population Studies Center, Institute for Social Research, University of Michigan, 426 Thompson Street, Room 2048 ISR, Ann Arbor, MI 48106 1248, USA
    J Gerontol B Psychol Sci Soc Sci 68:107-16. 2013
    ..of mortality and functional health decline, there are relatively few studies examining SRH as a predictor of morbidity. This study examines the capacity of SRH to predict the onset of chronic disease among the late midlife ..
  55. doi Morbidity of focal therapy in the treatment of localized prostate cancer
    Eric Barret
    Urology Service, Department of Surgery, Institut Mutualiste Montsouris, Paris, France
    Eur Urol 63:618-22. 2013
    ..Focal therapy (FT) for prostate cancer (PCa) seems to be part of a natural evolution in the quest to improve the management of early organ-confined disease...
  56. ncbi Neurocognitive and behavioral morbidity in children with sleep disorders
    David Gozal
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Curr Opin Pulm Med 13:505-9. 2007
    ..Particular focus is given to pediatric obstructive sleep apnea...
  57. pmc Disentangling the roles of disability and morbidity in survival to exceptional old age
    Dellara F Terry
    New England Centenarian Study, Geriatrics Section of the Department of Medicine, Boston University School of Medicine and Boston Medical Center, MA 02118, USA
    Arch Intern Med 168:277-83. 2008
    ..Therefore, we hypothesize that for some centenarians, compression of disability rather than morbidity is a key feature for survival to old age.
  58. pmc HCV-related burden of disease in Europe: a systematic assessment of incidence, prevalence, morbidity, and mortality
    Nikolai Mühlberger
    Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, UMIT University of Health Sciences, Medical Informatics and Technology, Hall iT, Austria
    BMC Public Health 9:34. 2009
    ..We summarised burden of disease data presently available for Europe, compared the data to current expert estimates, and identified areas in which better data are needed...
  59. pmc Rapid fluid removal during dialysis is associated with cardiovascular morbidity and mortality
    Jennifer E Flythe
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 79:250-7. 2011
    Patients receiving hemodialysis have high rates of cardiovascular morbidity and mortality that may be related to the hemodynamic effects of rapid ultrafiltration...
  60. pmc Morbidity and mortality in long-term survivors of Hodgkin lymphoma: a report from the Childhood Cancer Survivor Study
    Sharon M Castellino
    Department of Pediatrics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Blood 117:1806-16. 2011
    ..6; 95% CI 1.4-5.1), or a serious cardiovascular condition (HR, 4.4; 95% CI 2.7-7.3). Excess mortality from second neoplasms and cardiovascular disease vary by sex and persist > 20 years of follow-up in childhood HL survivors...
  61. doi Hospital discharge data can be used for monitoring procedures and intensive care related to severe maternal morbidity
    Anne A Chantry
    INSERM, UMR S953, Epidemiological Research on Perinatal Health and Women s and Children s Health, F 75020, Paris, France
    J Clin Epidemiol 64:1014-22. 2011
    To estimate the accuracy and reliability of the reporting of diagnoses and procedures related to severe acute maternal morbidity in French hospital discharge data.
  62. pmc Food insecurity is associated with morbidity and patterns of healthcare utilization among HIV-infected individuals in a resource-poor setting
    Sheri D Weiser
    Division of HIV AIDS, San Francisco General Hospital, University of California, San Francisco, 94143, USA
    AIDS 26:67-75. 2012
    We undertook a longitudinal study in rural Uganda to understand the association of food insecurity with morbidity and patterns of healthcare utilization among HIV-infected individuals enrolled in an antiretroviral therapy program.
  63. ncbi Traumatic grief as a risk factor for mental and physical morbidity
    H G Prigerson
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Am J Psychiatry 154:616-23. 1997
    ..The aim of this study was to confirm and extend the authors' previous work indicating that symptoms of traumatic grief are predictors of future physical and mental health outcomes...
  64. ncbi Herpes simplex encephalitis in Sweden, 1990-2001: incidence, morbidity, and mortality
    Anders Hjalmarsson
    Infectious Diseases Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
    Clin Infect Dis 45:875-80. 2007
    ..Herpes simplex encephalitis (HSE) is a devastating disease...
  65. doi Perforated peptic ulcer: clinical presentation, surgical outcomes, and the accuracy of the Boey scoring system in predicting postoperative morbidity and mortality
    Varut Lohsiriwat
    Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Prannok Road, Bangkok, 10700, Thailand
    World J Surg 33:80-5. 2009
    The purposes of this study were to determine clinical presentations and surgical outcomes of perforated peptic ulcer (PPU), and to evaluate the accuracy of the Boey scoring system in predicting mortality and morbidity.
  66. doi Determinants of morbidity and survival after elective non-curative resection of stage IV colon and rectal cancer
    Axel Kleespies
    Department of Surgery, Klinikum Grosshadern, University of Munich LMU, Marchioninistrasse 15, 81377 Munich, Germany
    Int J Colorectal Dis 24:1097-109. 2009
    ..The benefit of elective primary tumor resection for non-curable stage IV colorectal cancer (CRC) remains largely undefined. We wanted to identify risk factors for postoperative complications and short survival...
  67. doi No rebound of morbidity following intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants in Gabon
    Martin P Grobusch
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    J Infect Dis 200:1658-61. 2009
    ..These results do not appear to support the concept of a rebound effect after intermittent preventive sulfadoxine-pyrimethamine treatment of malaria in infants. Clinical trials registration. NCT00167843...
  68. ncbi Maternal-perinatal morbidity and mortality associated with adolescent pregnancy in Latin America: Cross-sectional study
    Agustin Conde-Agudelo
    Department of Obstetrics and Gynecology, Fundacion Clinica Valle del Lili, Cali, Colombia
    Am J Obstet Gynecol 192:342-9. 2005
    ..This study was undertaken to determine whether adolescent pregnancy is associated with increased risks of adverse pregnancy outcomes...
  69. ncbi Maternal morbidity and perinatal outcomes among pregnant women with respiratory hospitalizations during influenza season
    Tina V Hartert
    Department of Medicine, Division of General Internal Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Obstet Gynecol 189:1705-12. 2003
    A population-based assessment of maternal and perinatal morbidity related to respiratory illness during influenza season among pregnant women has not been published...
  70. ncbi Microbial keratitis predisposing factors and morbidity
    Lisa Keay
    School of Optometry and Vision Science, University of New South Wales, Sydney, Australia
    Ophthalmology 113:109-16. 2006
    ..To examine predisposing factors, treatment costs, and visual outcome of microbial keratitis in an ophthalmic casualty and inpatient population...
  71. ncbi Sinusoidal injury increases morbidity after major hepatectomy in patients with colorectal liver metastases receiving preoperative chemotherapy
    Hiroshi Nakano
    Centre de Chirurgie Viscerale et de Transplantation, Hopital de Hautepierre, Hopitaux Universitaires de Strasbourg, Universite Louis Pasteur, Avenue Moliere, Strasbourg, France
    Ann Surg 247:118-24. 2008
    ..To investigate whether sinusoidal injury (SI) was associated with a worse outcome after hepatectomy in patients with colorectal liver metastases (CRLM)...
  72. pmc Impact of mass distribution of free long-lasting insecticidal nets on childhood malaria morbidity: the Togo National Integrated Child Health Campaign
    Dianne J Terlouw
    Child and Reproductive Health, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK
    Malar J 9:199. 2010
    An evaluation of the short-term impact on childhood malaria morbidity of mass distribution of free long-lasting insecticidal nets (LLINs) to households with children aged 9-59 months as part of the Togo National Integrated Child Health ..
  73. ncbi Transsphenoidal surgery for pituitary tumors in the United States, 1996-2000: mortality, morbidity, and the effects of hospital and surgeon volume
    Fred G Barker
    Brain Tumor Center, Neurosurgical Service, Departments of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:4709-19. 2003
    ..This analysis suggests that higher-volume hospitals and surgeons provide superior short-term outcomes after transsphenoidal pituitary tumor surgery with shorter lengths of stay and a trend toward lower charges...
  74. ncbi Influenza-associated hospitalizations in the United States
    William W Thompson
    Epidemiology and Surveillance Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 292:1333-40. 2004
    ..Respiratory viral infections are responsible for a large number of hospitalizations in the United States each year...
  75. ncbi Morbidity and mortality during heatwaves in metropolitan Adelaide
    Monika Nitschke
    South Australian Department of Health, Adelaide, SA, Australia
    Med J Aust 187:662-5. 2007
    To investigate morbidity and mortality associated with heatwaves in metropolitan Adelaide using ambulance, hospital admission, and mortality data.
  76. pmc Indoor residual spraying of insecticide and malaria morbidity in a high transmission intensity area of Uganda
    Ruth Kigozi
    Uganda Malaria Surveillance Project, Kampala, Uganda
    PLoS ONE 7:e42857. 2012
    ..Recently the use of indoor residual spraying of insecticide (IRS) has greatly increased in Africa; however, limited data exist on the quantitative impacts of IRS on health outcomes in highly malaria endemic areas...
  77. ncbi The efficacy of permethrin-treated bed nets on child mortality and morbidity in western Kenya I. Development of infrastructure and description of study site
    Penelope A Phillips-Howard
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Trop Med Hyg 68:3-9. 2003
    ..We outline the development of the human and physical infrastructure required to conduct this trial and discuss some of the difficulties encountered and lessons learned in conducting it...
  78. ncbi Inner City Asthma Study: relationships among sensitivity, allergen exposure, and asthma morbidity
    Rebecca S Gruchalla
    University of Texas Southwestern Medical Center at Dallas, 75390 8859, USA
    J Allergy Clin Immunol 115:478-85. 2005
    Asthma-associated morbidity is rising, especially in inner city children.
  79. doi Effect of late-preterm birth and maternal medical conditions on newborn morbidity risk
    Carrie K Shapiro-Mendoza
    Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3717, USA
    Pediatrics 121:e223-32. 2008
    ..account for nearly three quarters of all preterm births in the United States, yet little is known about their morbidity risk...
  80. ncbi The Postoperative Morbidity Survey was validated and used to describe morbidity after major surgery
    M P W Grocott
    Surgical Outcome Research Centre, University College London Hospitals, London, W1T 3AA, UK
    J Clin Epidemiol 60:919-28. 2007
    To describe the reliability and validity of the Postoperative Morbidity Survey (POMS). To describe the level and pattern of short-term postoperative morbidity after major elective surgery using the POMS.
  81. doi Physical activity, fitness and fatness: relations to mortality, morbidity and disease risk factors. A systematic review
    M Fogelholm
    The Academy of Finland, Health Research Unit, 00501 Helsinki, Finland
    Obes Rev 11:202-21. 2010
    ..The conclusions of the present review may not be applicable to individuals with BMI > 35...
  82. pmc Prevalence of chronic diseases and morbidity in primary health care in central Greece: an epidemiological study
    Markos Minas
    Respiratory Medicine Department, University of Thessaly Medical School, Larissa, Greece
    BMC Health Serv Res 10:252. 2010
    In Greece there is lack of large epidemiological studies regarding morbidity and mortality in primary health care...
  83. doi Central compartment reoperation for recurrent/persistent differentiated thyroid cancer: patterns of recurrence, morbidity, and prediction of postoperative hypocalcemia
    Jong Lyel Roh
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Ann Surg Oncol 18:1312-8. 2011
    ..We investigated recurrence patterns, morbidity, and factors predictive of postoperative hypocalcemia in patients undergoing central compartment reoperation for ..
  84. pmc The effect of tight glycaemic control, during and after cardiac surgery, on patient mortality and morbidity: A systematic review and meta-analysis
    Kristin K Haga
    School of Medicine and Veterinary Medicine, University of Edinburgh, Chancellors Building, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    J Cardiothorac Surg 6:3. 2011
    ..The aim of this study was to systematically review the literature to determine the effects of tight versus normal glycaemic control, during and after cardiac surgery, on measures of morbidity and mortality.
  85. pmc AIDS and non-AIDS morbidity and mortality across the spectrum of CD4 cell counts in HIV-infected adults before starting antiretroviral therapy in Cote d'Ivoire
    Xavier Anglaret
    INSERM U897 and the Université Bordeaux Segalen, Bordeaux, France
    Clin Infect Dis 54:714-23. 2012
    ..In sub-Saharan Africa, these CD4 cell count-specific estimates are scarce...
  86. doi Severe maternal morbidity during childbirth hospitalisation: a comparative analysis between the Republic of Ireland and Australia
    Jennifer E Lutomski
    National Perinatal Epidemiology Centre, Cork, Ireland
    Eur J Obstet Gynecol Reprod Biol 163:148-53. 2012
    To determine the population-based rates of severe maternal morbidity during childbirth hospitalisation and associated characteristics in the Republic of Ireland and to directly compare incidence rates with Australia.
  87. doi Implications of the first cesarean: perinatal and future reproductive health and subsequent cesareans, placentation issues, uterine rupture risk, morbidity, and mortality
    Robert M Silver
    Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT 84132, USA
    Semin Perinatol 36:315-23. 2012
    ..The risk dramatically worsens in patients with multiple repeat cesarean deliveries. This article will summarize and highlight the implications of the rising cesarean rate on maternal and fetal morbidity and mortality.
  88. doi Estimation of preterm birth rate, associated factors and maternal morbidity from a demographic and health survey in Brazil
    Ricardo P Tedesco
    Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, Sao Paulo, Brazil
    Matern Child Health J 17:1638-47. 2013
    ..Odds ratios and 95 % CI were estimated for complications such as severe maternal morbidity. The preterm birth rate was 9.9 %, with regional variations...
  89. pmc Malaria morbidity in high and seasonal malaria transmission area of Burkina Faso
    Alphonse Ouedraogo
    Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
    PLoS ONE 8:e50036. 2013
    ..This study aims to describe the epidemiology of malaria prior to the conduct of a series of drug and vaccine trials in a rural area of Burkina Faso...
  90. pmc Incidence, determinants and perinatal outcomes of near miss maternal morbidity in Ile-Ife Nigeria: a prospective case control study
    Ikeola A Adeoye
    Department of Epidemiology and Medical Statistics, College of Medicine, University of Ibadan, Ibadan, Nigeria
    BMC Pregnancy Childbirth 13:93. 2013
    ..The study determined the incidence, characteristics, determinants and perinatal outcomes of near misses in a tertiary hospital in South-west Nigeria...
  91. pmc Age-specific trends in morbidity, mortality and case-fatality from cardiovascular disease, myocardial infarction and stroke in advanced age: evaluation in the Swedish population
    Karin Modig
    Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 8:e64928. 2013
    ..It is not clear if the downward trend in cardiovascular disease (CVD) observed for ages up to 85 years can be extended to the oldest old, those 85 years and above...
  92. ncbi Introduction to Danish (nationwide) registers on health and social issues: structure, access, legislation, and archiving
    Lau Caspar Thygesen
    National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    Scand J Public Health 39:12-6. 2011
    ..We introduce the Danish Data Archive and briefly present the Act on Processing of Personal Data, which is the legal foundation for analyses of register-based data in Denmark...
  93. pmc The effect of HIV on morbidity and mortality in children with severe malarial anaemia
    Samuel Malamba
    CDC Uganda, Global AIDS Program, National Center for HIV, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Malar J 6:143. 2007
    Malaria and HIV are common causes of mortality in sub-Saharan Africa. The effect of HIV infection on morbidity and mortality in children with severe malarial anaemia was assessed.
  94. pmc Evaluation of morbidity, mortality and outcome following cervical spine injuries in elderly patients
    S A Malik
    National Spinal Injury Unit, Mater Misericordiae Hospital, 59 Eccles Street, Dublin 2, Ireland
    Eur Spine J 17:585-91. 2008
    We analysed the morbidity, mortality and outcome of cervical spine injuries in patients over the age of 65 years...
  95. doi Influenza-associated morbidity in subtropical Taiwan
    Chung Min Liao
    Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei 10617, Taiwan
    Int J Infect Dis 13:589-99. 2009
    The purpose of this study was to assess the characteristics of influenza-associated morbidity in subtropical Taiwan, corresponding to the seasonal patterns, weather, and co-circulation of influenza (sub)types, and other respiratory ..
  96. doi Measuring the gap: accuracy of the Western Australian hospital morbidity data in the identification of adult urban Aboriginal and Torres Strait Islander people
    Pamela J Bradshaw
    School of Population Health, University of Western Australia, Australia
    Aust N Z J Public Health 33:276-9. 2009
    ..To assess the sensitivity of the recording of Aboriginality in the Western Australia Linked Data...
  97. pmc Differential effects of outdoor versus indoor fungal spores on asthma morbidity in inner-city children
    Jacqueline A Pongracic
    Children s Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    J Allergy Clin Immunol 125:593-9. 2010
    Although sensitization to fungal allergens is prevalent in inner-city children with asthma, the relationship between fungal exposure and morbidity is poorly understood.
  98. doi Impact of the pneumococcal vaccine on long-term morbidity and mortality of adults at high risk for pneumonia
    Jennie Johnstone
    Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    Clin Infect Dis 51:15-22. 2010
    ..We determined whether PPV was associated with reduced mortality or additional hospitalization for vaccine-preventable infections in patients previously hospitalized for community-acquired pneumonia (CAP)...
  99. ncbi Stunting associated with poor socioeconomic and maternal nutrition status and respiratory morbidity in Colombian schoolchildren
    Louise H Dekker
    Harvard School of Public Health, Boston, Massachusetts, USA 48109, USA
    Food Nutr Bull 31:242-50. 2010
    ..There are few recent reports on the prevalence and risk factors of stunting and thinness among schoolchildren in Latin America...
  100. doi Severe acute maternal morbidity and mode of delivery in the Netherlands
    Jeroen van Dillen
    Department of Obstetrics, Leiden University Medical Center, The Netherlands
    Acta Obstet Gynecol Scand 89:1460-5. 2010
    To evaluate the risk of severe acute maternal morbidity (SAMM) related to mode of delivery.
  101. doi Morbidity among human immunodeficiency virus-exposed but uninfected, human immunodeficiency virus-infected, and human immunodeficiency virus-unexposed infants in Zimbabwe before availability of highly active antiretroviral therapy
    Ai Koyanagi
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Pediatr Infect Dis J 30:45-51. 2011
    Human immunodeficiency virus (HIV) remains a major cause of pediatric morbidity in Africa...

Research Grants91

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator Arrays
    Ryan Bailey; Fiscal Year: 2009
    ..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
  3. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..by blood transfusion, and altered host immunity from hypersplenism and iron overload contribute to the morbidity. Specific transfusion protocols are followed and all transfused patients are screened annually for hepatitis B ..
  4. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..Hence, limiting this injury is of paramount importance for reducing the morbidity and mortality associated with ischemic heart disease...
  5. Yasmin Wadia; Fiscal Year: 2014
    ..Safety will be assessed by tabulating the frequency of adverse events, such as 30 day postoperative morbidity due to a) secondary infection, intra-abdominal abscess formation and septicemia, b) late bleeding or secondary ..
  6. Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory Ther
    ALEXANDRA ROSE LUCAS; Fiscal Year: 2010
    ..for occlusive or aneurysmal vascular changes is based upon watchful surveillance with potential high associated morbidity and mortality. Even with treatment, disease can progress and recur with cessation of treatment...
  7. CFI Pathogen Inactivation Technology
    Trevor P Castor; Fiscal Year: 2010
    ..and the screening of donated blood for various serological markers have significantly reduced the mortality and morbidity due to transfusion-associated infectious agents...
  8. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..Although advances in surgery, and combined of radio and chemotherapies, have decreased morbidity, the survival rate at 5 years after initial prognosis remains at <50%...
  9. MERVYN N WEITZMANN; Fiscal Year: 2016
    ..DESCRIPTION (provided by applicant): Bone fractures resulting from osteoporosis lead to significant health costs, morbidity, loss of mobility, and often mortality in aged individuals...
  10. Carole R Mendelson; Fiscal Year: 2016
    ..of prematurely born infants can result in respiratory distress syndrome (RDS), the leading cause of neonatal morbidity and mortality in the U.S...
  11. Role of NGF in inflammatory and proliferative cascades of psoriatic disease
    Siba P Raychaudhuri; Fiscal Year: 2012
    ..RELEVANCE TO VA PATIENT POPULATION: Psoriatic disease is a major morbidity among the VA patient population with profound social and economic impacts...
  12. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..MS generally causes cardiovascular disease (CVD), which is the leading cause of mortality and morbidity in the United States. Insulin resistance is a central component defining the MS...
  13. Noreen F Rossi; Fiscal Year: 2016
    ..with or without stenting in controlling arterial pressure, decreasing cardiac or renal events, or reducing morbidity and mortality remain unproven and controversial...
  14. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..Cachexia is a significant contributor to the overall increased morbidity and mortality in patients with overwhelming infections, and in patients with chronic inflammation and cancer, ..
  15. Effective treatment of sleep apnea in prediabetes to reduce cardiometabolic risk
    Esra Tasali; Fiscal Year: 2010
    ..Diabetes is increasing in epidemic proportions in the U.S. Cardiovascular disease is the leading cause of morbidity and mortality in diabetes...
  16. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..The veteran population is predominantly male and has a high prevalence of psychiatric co-morbidity. Furthermore, veterans with schizophrenia who are able to sustain full employment often seek their healthcare ..
  17. Emilio B Gonzalez; Fiscal Year: 2014
    ..Thrombosis is an important cause of morbidity and mortality in APS and SLE patients with aPL Abs...
  18. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    ..Despite aggressive treatment, ALI/ARDS continue to cause significant mortality and morbidity among trauma/hemorrhagic shock patients and innovative therapeutic approaches are needed...
  19. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..with the development of heart failure, which remains a major public health crisis and a leading cause of morbidity and mortality in aged men and women...
  20. Patrice G Guyenet; Fiscal Year: 2015
    ..disrupts sleep and causes a cohort of adverse health consequences including acute and chronic cardiovascular morbidity. Failure to arouse in response to asphyxia is equally problematic...
  21. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..results in long-term adverse effects on cardiovascular risk, there is likely to be an increase in veteran morbidity and mortality due to cardiovascular disease...
  22. BRIAN JAMES MCMAHON; Fiscal Year: 2016
    ..hepatitis C, non- alcoholic fatty liver disease and autoimmune hepatitis have been shown to cause substantial morbidity and mortality among Alaska Native persons...
  23. CLIFFORD RUSSELL GREYSON; Fiscal Year: 2016
    ..Right ventricular (RV) contractile failure from acute pulmonary hypertension is an important cause of morbidity and mortality in conditions such as massive pulmonary embolism, hypoxic pulmonary vasoconstriction, and ..
  24. ENEIQUE A MESRI; Fiscal Year: 2016
    ..and the proliferation of spindle cells that can affect the skin, mucosa and viscera, causing significant morbidity. Understanding the role of viral and cellular genes leading to KS carcinogenesis is paramount to developing ..
  25. A Redox-active PARP Inhibitor for Lung Transplantation
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..provided by applicant): Lung ischemia-reperfusion injury (IRI) is an acute lung injury that contributes to morbidity and mortality following lung transplantation (LTX)...
  26. Behavioral Activation Therapy for Rural Veterans with Diabetes and Depression
    Aanand Dinkar Naik; Fiscal Year: 2013
    ..If the proposed intervention is successful, it could make a significant contribution toward reducing morbidity associated with diabetes. 3. Approach. Criterion Score: 1...
  27. The role of Fli1 in T cell function and the pathogenesis of lupus
    Tamara K Nowling; Fiscal Year: 2011
    ..It also is 4-5 times more common in African Americans and Hispanics than Caucasians, and morbidity and mortality are greater in African Americans/Hispanics with lupus...
  28. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    Coronary artery disease (CAD) is the most common cause of morbidity and mortality worldwide. A cluster of metabolic phenotypes known as metabolic syndrome has been established as a major risk factor for CAD...
  29. Biology and Pathologies of Type V Collagen
    Daniel S Greenspan; Fiscal Year: 2013
    ..in the pathogenesis of atherosclerosis, and whether induction of col(V) immune tolerance can ameliorate the morbidity of atherosclerosis...
  30. Robert T Means; Fiscal Year: 2014
    ..PUBLIC HEALTH RELEVANCE: Anemia is a major contributor to morbidity and mortality in chronically ill patients, and the anemia of chronic disease (ACD) is the major etiology of this ..
  31. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    ..Reducing blood pressure to normal levels decreases the morbidity and mortality associated with hypertension, but does not bring morbidity and mortality back to control levels...
  32. CYNTHIA T MCEVOY; Fiscal Year: 2016
    ..Smoking is a unique morbidity in that it is addictive, heavily advertised and recent genome studies show there are genotypes that ..
  33. Junxuan Lu; Fiscal Year: 2014
    ..Chemoprevention has become recognized as a plausible and cost-effective alternative approach to reduce the morbidity and mortality of PCa...
  34. Shervin Assassi; Fiscal Year: 2014
    ..Proposed Research: SSc is associated with substantial morbidity and mortality. Pulmonary involvement is the primary cause of SSc-related death...
  35. TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion Injury
    LORI ANN HOLLE; Fiscal Year: 2011
    ..This proposal focuses on cerebral IRI, a significant clinical problem contributing to considerable morbidity and large numbers of deaths...
  36. PAUL CAMILLE TUMEH; Fiscal Year: 2015
    ..The direct cost associated with this significant morbidity and mortality has been estimated to be 1.4 billion US dollars annually...
  37. Melissa A Rosenkranz; Fiscal Year: 2014
    ..have a two-fold higher risk of developing a mood or anxiety disorder than those without asthma and this co-morbidity is associated with poorer asthma control, increased symptom frequency, and more physician and emergency room ..
  38. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..derived mainly from fish-oil) based upon purported effects that include: reduction in cardiovascular morbidity and mortality, reduction in cerebrovascular disease and stroke, preservation of vision, and slowing of cognitive ..
  39. Rinn Song; Fiscal Year: 2016
    ..PUBLIC HEALTH RELEVANCE: Tuberculosis is a leading cause of childhood morbidity and mortality worldwide...
  40. Thalachallour Mohanakumar; Fiscal Year: 2015
    ..clinically diagnosed as Bronchiolitis obliterans Syndrome (BOS), is the most significant long term cause of morbidity and mortality following human lung transplantation (LTx)...
  41. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Hypertension (HTN) is a leading cause of morbidity and mortality worldwide, contributing to cardiovascular disease, stroke, and end stage kidney disease...
  42. Roy Curtiss Iii; Fiscal Year: 2016
    ..but may account for about 40 percent of the total deaths with an even greater cost being due to the severe morbidity associated with these diseases (241)...
  43. William M Nauseef; Fiscal Year: 2016
    ..93 per 1,000 discharges in 2000 to 30.59 in 2007 ( 14%). Consequently, the attendant rises in morbidity and mortality present a significant challenge to our health care system...
  44. Novel diagnostic and safety biomarkers of liver injury and hepatotoxicity
    Stanislav I Svetlov; Fiscal Year: 2010
    Liver damage and failure due to various forms of hepatic injury is a significant source of overall morbidity and mortality in the US and worldwide...
  45. Identification and Analysis of Flavivirus Protease and RNA Helicase Inhibitors
    Radhakrishnan Padmanabhan; Fiscal Year: 2009
    ..virus (YFV), West Nile virus (WNV) and Dengue (DEN1-4) viruses that cause serious illnesses with considerable morbidity and mortality...
  46. Yaya Wang; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Autoimmune diseases in aggregate represent a leading cause of morbidity and mortality...
  47. JoAnn Sekiguchi; Fiscal Year: 2014
    ..feature of A-T is progressive neurodegeneration;however, in addition to cancer, one of the leading causes of morbidity and mortality is respiratory system disease, including interstitial lung disease (ILD)...
  48. ER stress: role in myocyte apoptosis and myocardial remodeling
    Krishna Singh; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Heart failure represents a major cause of morbidity and mortality among veterans. Increased sympathetic activity is a central feature in patients with heart failure...
  49. Efficacy of Yoga for Treatment-Resistant PTSD
    Bessel Van der Kolk; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Because about 7.8% of the US population suffers from PTSD, which has high co-morbidity with multiple medical, social and occupational problems, and because more than 10% of the US population has a ..
  50. A quantitative proteomics approach to understand viral immune evasion strategies
    Michele E Hardy; Fiscal Year: 2010
    ..These viruses are responsible for significant morbidity in developed countries with an estimated 2...
  51. Mechanism-Based Discovery of Protectants Against Iron-Dependant Oxidative Injury
    JUSTIN M SCHWARTZ; Fiscal Year: 2011
    ..Ischemia-reperfusion (I/R) injury by way of heart attacks, strokes and diabetes is one of the major causes of morbidity and mortality in the United States...
  52. Roy Curtiss Iii; Fiscal Year: 2014
    ..difficile. These pathogens are responsible for significant morbidity and are transmitted to humans by contaminated food and water...
  53. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Pancreatic inflammation results in morbidity and mortality, with severe intractable pain...
  54. SAUL R TZIPORI; Fiscal Year: 2014
    ..CDI) has increased significantly in both North America and Europe, causing lengthy hospitalization, substantial morbidity and mortality...
  55. Unbiased genome-wide screen to identify genes regulating mucous cell hyperplasia
    Jeffrey A Whitsett; Fiscal Year: 2010
    ..sinusitis, allergic rhinitis, middle ear disease, as well as pulmonary disease that contribute to respiratory morbidity and mortality world wide...
  56. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..mechanical ventilation and/or nasal positive airway pressure, number of days on supplemental oxygen, and overall morbidity and mortality (%)...
  57. Ken R Smith; Fiscal Year: 2015
    ..Health outcomes are age-specific all-cause and cause-specific mortality, co-morbidity risks, site-specific cancer incidence, and morbidity trajectories. Aim 2...
  58. The genetics and pathophysiology of impaired Wnt signaling in metabolic syndrome
    Arya Mani; Fiscal Year: 2012
    ..is a major risk factor for development of diabetes and coronary artery disease (CAD), two most common causes of morbidity and mortality worldwide...
  59. Small Molecule targeting of NADPH oxidase in neutrophils
    Marie Dominique Filippi; Fiscal Year: 2010
    ..In general, lung airway diseases are amongst the leading causes of morbidity and mortality in the United States of America...
  60. An Aldosterone-Endothelin Feedback Mechanism on Sodium Homeostasis
    Charles S Wingo; Fiscal Year: 2012
    ..Results from two recent clinical studies (RALES and EPHESUS) demonstrated that aldosterone blockade reduced morbidity and mortality even in patients already receiving angiotensin- converting enzyme-inhibitors and beta blockers...
  61. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Disorders of the hematopoietic system are a common cause of morbidity and mortality in the United States...
  62. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ..Excess morbidity and mortality from AD continue to generate an enormous economic burden on families and on the United States...
  63. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    Atherosclerosis, the leading cause of morbidity and mortality in industrialized nations, is a fibro-proliferative disease associated with endothelial injury, recruitment of inflammatory cells (macrophages and T cells), expansion of ..
  64. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    ..Veterans'Health Heart attacks and strokes account for the first and third leading causes of mortality and morbidity in the United States, respectively...
  65. DNA Repair Capacity and Risk of Pre-malignant Lesion in Lung Epithelium
    Hua Zhao; Fiscal Year: 2009
    ..lesions in central airway in high risk population has significant implication in decreasing lung cancer morbidity and mortality...
  66. Severe H1N1 Influenza Infection During Pregnancy: Pathophysiologic Mechanisms
    Mark Phillippe; Fiscal Year: 2010
    ..Although the early phase of this new pandemic has been associated with mild morbidity and low mortality, a significant numbers of patients have died in the U.S. and world-wide...
  67. Validation of a functional MRI-based reward processing task as a non-invasive too
    MARY LOUISE PHILLIPS; Fiscal Year: 2010
    ..bipolar disorder and attention-deficit/hyperactivity disorder (ADHD) are amongst the most significant causes of morbidity and mortality in the USA. Although treatments for these disorders are available they are less than adequate...
  68. Planning a clinical trial of Flash-heated breast milk to decrease morbidity, impr
    Caroline J Chantry; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Planning an efficacy trial of Flash-heated breast milk to decrease morbidity, improve growth, and reduce HIV transmission in HIV-exposed infants The World Health Organization recommends that HIV ..
  69. Does ArsenicMitigation in BangladeshRaiseExposure to Bacterial and ViralPathogens
    ALEXANDER FRANS VAN GEEN; Fiscal Year: 2010
    ..Nevertheless, reductions in diarrheal morbidity in much of the developing world have been modest, possibly because of a lack of sufficient parallel improvements ..
  70. PROJECTED HEAT WAVE MAGNITUDES AND PUBLIC HEALTH IMPACTS
    Helene G Margolis; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Background: Virtually all heat-related morbidity/mortality (HRMM) is preventable, yet extreme heat events (EHE) remain the leading cause of weather-related deaths in the United States...
  71. RESPIRATORY DISEASES/BSI STUDY
    Shahin Lockman; Fiscal Year: 2004
    ..prevention in Botswana, as well as studies of other aspects of HIV epidemiology and infant infectious disease morbidity and mortality...
  72. Human in Mouse Modeling of HNSCC to Predict Resonse to Therapy
    Wendell G Yarbrough; Fiscal Year: 2010
    ..nerves and major blood vessels in the neck, standard therapeutic modalities frequently result in unacceptable morbidity including speech and swallowing defects, shoulder dysfunction, accelerated arteriosclerosis of the carotid, ..
  73. A new class of biodegradable synthetic biomaterial for seroma prevention
    Michael Craven; Fiscal Year: 2012
    ..Without timely intervention post-operative seromas can lead to significant patient morbidity including infection, tissue necrosis, permanent cystic cavities, reduced limb mobility and permanent ..
  74. Effects of Maternal Influenza Immunization: A Field Trial in Guatemala'
    Saad B Omer; Fiscal Year: 2010
    ..Influenza virus is an important respiratory pathogen that causes substantial burden of disease - including morbidity and mortality among pregnant women and young infants...
  75. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The objective of the project is to validate an experimental model of co-morbidity between depression and temporal lobe epilepsy (TLE), and to establish the mechanistic connection between the two ..
  76. Maternal Morbidity and Mortality in Multiple Pregnancy
    Barbara Luke; Fiscal Year: 2006
    ..born early preterm and very low birthweight, important well-documented factors that contribute to their excess morbidity and mortality. In contrast, far less is known about how multiple pregnancies affects the health of the mother...
  77. Chronic alcohol and pulmonary immunity
    Kevin L Legge; Fiscal Year: 2010
    ..Indeed, alcoholics compared to non-alcoholic individuals have increased mortality and morbidity during bacterialpneumonias...
  78. Development of a Univalent Vaccine Against Group B Streptococci Infection
    Stephen K Hunter; Fiscal Year: 2010
    Group B Streptococci (GBS) has emerged as one of the most important infectious causes of neonatal morbidity and mortality and pregnancy-related morbidity...
  79. Morbidity and Mortality in Marysville, Ohio due to Exposure to Asbestos Contamina
    James Lockey; Fiscal Year: 2010
    Description: (Provided by Applicant): Morbidity and Mortality in Marysville, Ohio due to Exposure to Asbestos Contaminated Vermiculite Occupational and environmental exposure to vermiculite mined in Libby, Montana is associated with ..
  80. CHICAGO INNER CITY ASTHMA STUDY
    Richard Evans; Fiscal Year: 2001
    ..Any intervention to reduce morbidity in this Medicaid-dependent population should not only be multifaceted but also reasonably priced...
  81. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    ..and their modifying influence on allergic inflammation may partly explain the increase in asthma prevalence, morbidity, and mortality...
  82. Relationship of Morbidity and Mortality Between Spouses
    Nicholas Christakis; Fiscal Year: 2006
    ..the perspective and methods of the demography of aging, we propose to examine the relationship between the morbidity and mortality of spouses...
  83. Racial/ethnic differences in symptom perception in childhood asthma
    Jonathan Feldman; Fiscal Year: 2009
    ..Puerto Rican children have the highest asthma prevalence, morbidity, and mortality rates, and Mexican-American children have the lowest rates...