life expectancy

Summary

Summary: A figure representing the number of years, based on known statistics, to which any person of a given age may reasonably expect to live.

Top Publications

  1. pmc Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lancet 380:219-29. 2012
  2. pmc Increases in adult life expectancy in rural South Africa: valuing the scale-up of HIV treatment
    Jacob Bor
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Post Office Box 198, Mtubatuba, KwaZulu Natal 3935, South Africa
    Science 339:961-5. 2013
  3. ncbi Healthy life expectancy for 187 countries, 1990-2010: a systematic analysis for the Global Burden Disease Study 2010
    Joshua A Salomon
    Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Lancet 380:2144-62. 2012
  4. ncbi Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study
    Chi Pang Wen
    Institute of Population Science, National Health Research Institutes, Zhunan, Taiwan
    Lancet 378:1244-53. 2011
  5. ncbi A potential decline in life expectancy in the United States in the 21st century
    S Jay Olshansky
    University of Illinois at Chicago, Chicago 60612, USA
    N Engl J Med 352:1138-45. 2005
  6. pmc Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study
    Margaret May
    School of Social and Community Medicine, Bristol University, Bristol BS8 2PS, UK
    BMJ 343:d6016. 2011
  7. ncbi Demography. Broken limits to life expectancy
    Jim Oeppen
    Cambridge Group for the History of Population and Social Structure, Cambridge University, Cambridge, CB2 3EN, UK
    Science 296:1029-31. 2002
  8. ncbi Survival of persons with and without HIV infection in Denmark, 1995-2005
    Nicolai Lohse
    Department of Infectious Diseases, Odense University Hospital and University of Southern Denmark, Odense, Denmark
    Ann Intern Med 146:87-95. 2007
  9. ncbi Life expectancy of persons receiving combination antiretroviral therapy in low-income countries: a cohort analysis from Uganda
    Edward J Mills
    University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 155:209-16. 2011
  10. pmc Life expectancy at birth for people with serious mental illness and other major disorders from a secondary mental health care case register in London
    Chin Kuo Chang
    King s College London Institute of Psychiatry, London, United Kingdom
    PLoS ONE 6:e19590. 2011

Detail Information

Publications392 found, 100 shown here

  1. pmc Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy
    I Min Lee
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lancet 380:219-29. 2012
    ..diseases such as coronary heart disease, type 2 diabetes, and breast and colon cancers, and shortens life expectancy. Because much of the world's population is inactive, this link presents a major public health issue...
  2. pmc Increases in adult life expectancy in rural South Africa: valuing the scale-up of HIV treatment
    Jacob Bor
    Africa Centre for Health and Population Studies, University of KwaZulu Natal, Post Office Box 198, Mtubatuba, KwaZulu Natal 3935, South Africa
    Science 339:961-5. 2013
    The scale-up of antiretroviral therapy (ART) is expected to raise adult life expectancy in populations with high HIV prevalence...
  3. ncbi Healthy life expectancy for 187 countries, 1990-2010: a systematic analysis for the Global Burden Disease Study 2010
    Joshua A Salomon
    Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Lancet 380:2144-62. 2012
    Healthy life expectancy (HALE) summarises mortality and non-fatal outcomes in a single measure of average population health. It has been used to compare health between countries, or to measure changes over time...
  4. ncbi Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort study
    Chi Pang Wen
    Institute of Population Science, National Health Research Institutes, Zhunan, Taiwan
    Lancet 378:1244-53. 2011
    ..physical activity are well known, but whether less exercise than the recommended 150 min a week can have life expectancy benefits is unclear...
  5. ncbi A potential decline in life expectancy in the United States in the 21st century
    S Jay Olshansky
    University of Illinois at Chicago, Chicago 60612, USA
    N Engl J Med 352:1138-45. 2005
    Forecasts of life expectancy are an important component of public policy that influence age-based entitlement programs such as Social Security and Medicare...
  6. pmc Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study
    Margaret May
    School of Social and Community Medicine, Bristol University, Bristol BS8 2PS, UK
    BMJ 343:d6016. 2011
    To estimate life expectancy for people with HIV undergoing treatment compared with life expectancy in the general population and to assess the impact on life expectancy of late treatment, defined as CD4 count <200 cells/mm(3) at start ..
  7. ncbi Demography. Broken limits to life expectancy
    Jim Oeppen
    Cambridge Group for the History of Population and Social Structure, Cambridge University, Cambridge, CB2 3EN, UK
    Science 296:1029-31. 2002
  8. ncbi Survival of persons with and without HIV infection in Denmark, 1995-2005
    Nicolai Lohse
    Department of Infectious Diseases, Odense University Hospital and University of Southern Denmark, Odense, Denmark
    Ann Intern Med 146:87-95. 2007
    ..The expected survival of HIV-infected patients is of major public health interest...
  9. ncbi Life expectancy of persons receiving combination antiretroviral therapy in low-income countries: a cohort analysis from Uganda
    Edward J Mills
    University of Ottawa, Ottawa, Ontario, Canada
    Ann Intern Med 155:209-16. 2011
    Little is known about the effect of combination antiretroviral therapy (cART) on life expectancy in sub-Saharan Africa.
  10. pmc Life expectancy at birth for people with serious mental illness and other major disorders from a secondary mental health care case register in London
    Chin Kuo Chang
    King s College London Institute of Psychiatry, London, United Kingdom
    PLoS ONE 6:e19590. 2011
    ..The electronic database from a large and comprehensive secondary mental healthcare provider in London was utilized to assess the impact of SMI diagnoses on life expectancy at birth.
  11. ncbi Life expectancy among persons with schizophrenia or bipolar affective disorder
    Thomas Munk Laursen
    National Centre for Register Based Research, Aarhus University, Taasingegade 1, 8000 Aarhus C, Denmark
    Schizophr Res 131:101-4. 2011
    ..Mortality rates among individuals with schizophrenia or bipolar disorder are elevated compared to the general population...
  12. ncbi Projected life expectancy of people with HIV according to timing of diagnosis
    Fumiyo Nakagawa
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, University College London, UK
    AIDS 26:335-43. 2012
    ..Our aims were to estimate the life expectancy of an HIV-infected MSM living in a developed country with extensive access to ART and healthcare, and to ..
  13. ncbi Hazardous alcohol drinking and premature mortality in Russia: a population based case-control study
    David A Leon
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 369:2001-9. 2007
    The reason for the low life expectancy in Russian men and large fluctuations in mortality are unknown. We investigated the contribution of alcohol, and hazardous drinking in particular, to male mortality in a typical Russian city.
  14. pmc Fine-particulate air pollution and life expectancy in the United States
    C Arden Pope
    Department of Economics, Brigham Young University, Provo, UT 84602 2363, USA
    N Engl J Med 360:376-86. 2009
    ..morbidity and mortality, suggesting that sustained reductions in pollution exposure should result in improved life expectancy. This study directly evaluated the changes in life expectancy associated with differential changes in fine ..
  15. pmc Excess mortality, causes of death and life expectancy in 270,770 patients with recent onset of mental disorders in Denmark, Finland and Sweden
    Merete Nordentoft
    Psychiatric Centre Copenhagen, University of Copenhagen, Faculty of Health Sciences, Copenhagen, Denmark
    PLoS ONE 8:e55176. 2013
    ..Excess mortality among patients with severe mental disorders has not previously been investigated in detail in large complete national populations...
  16. ncbi Outcomes of Nordic mental health systems: life expectancy of patients with mental disorders
    Kristian Wahlbeck
    Nordic School of Public Health, Nordic Research Academy in Mental Health, Gothenburg, Sweden, and National Institute for Health and Welfare THL, Vaasa, Finland
    Br J Psychiatry 199:453-8. 2011
    People with mental disorders evince excess mortality due to natural and unnatural deaths. The relative life expectancy of people with mental disorders is a proxy measure of effectiveness of social policy and health service provision.
  17. pmc Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila
    Gerasimos P Sykiotis
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Dev Cell 14:76-85. 2008
    ..Interestingly, cancer chemopreventive drugs potently stimulate Drosophila Nrf2 activity, suggesting the fruit fly as an experimental system to identify and characterize such agents...
  18. ncbi Interferon therapy prolonged life expectancy among chronic hepatitis C patients
    Haruhiko Yoshida
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Bunkyo, Tokyo, Japan
    Gastroenterology 123:483-91. 2002
    ..The effects of interferon therapy in chronic hepatitis C patients on survival are unclear. Our objective was to analyze survival among a large cohort of chronic hepatitis C patients...
  19. pmc Cause-specific life expectancies after 35 years of age for human immunodeficiency syndrome-infected and human immunodeficiency syndrome-negative individuals followed simultaneously in long-term cohort studies, 1984-2008
    Nikolas Wada
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room E7648, Baltimore, MD 21205, USA
    Am J Epidemiol 177:116-25. 2013
    ..The results illuminate the changing face of mortality among the growing population infected with HIV...
  20. pmc Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening
    Chen Yu Liao
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Aging Cell 9:92-5. 2010
    ..Although strains with shortened lifespan under 40% DR may not respond negatively under less stringent DR, the results raise the possibility that life extension by DR may not be universal...
  21. ncbi Forecasting the effects of obesity and smoking on U.S. life expectancy
    Susan T Stewart
    Harvard University Interfaculty Program for Health Systems Improvement, Boston, MA, USA
    N Engl J Med 361:2252-60. 2009
    ..Having a better understanding of the joint effects of these trends on longevity and quality of life will facilitate more efficient targeting of health care resources...
  22. ncbi Cost-effectiveness of screening for HIV in the era of highly active antiretroviral therapy
    Gillian D Sanders
    Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
    N Engl J Med 352:570-85. 2005
    ..The costs, benefits, and cost-effectiveness of screening for human immunodeficiency virus (HIV) in health care settings during the era of highly active antiretroviral therapy (HAART) have not been determined...
  23. ncbi Achieving health equity: from root causes to fair outcomes
    Michael Marmot
    Lancet 370:1153-63. 2007
    ..These cries are forming a global movement. The Commission on Social Determinants of Health places action to ensure fair health at the head and the heart of that movement...
  24. ncbi Inequalities in healthy life years in the 25 countries of the European Union in 2005: a cross-national meta-regression analysis
    Carol Jagger
    Department of Health Sciences, University of Leicester, Leicester, UK
    Lancet 372:2124-31. 2008
    Although life expectancy in the European Union (EU) is increasing, whether most of these extra years are spent in good health is unclear...
  25. ncbi Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span
    Bradley J Willcox
    Pacific Health Research Institute, 846 South Hotel Street, Suite 301, Honolulu, HI 96813, USA
    Ann N Y Acad Sci 1114:434-55. 2007
    ..The low caloric intake, long life expectancy, and the high prevalence of centenarians in Okinawa have been used as an argument to support the CR ..
  26. ncbi Obesity in adulthood and its consequences for life expectancy: a life-table analysis
    Anna Peeters
    Department of Public Health, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Ann Intern Med 138:24-32. 2003
    Overweight and obesity in adulthood are linked to an increased risk for death and disease. Their potential effect on life expectancy and premature death has not yet been described.
  27. ncbi Alcohol and Russian mortality: a continuing crisis
    David A Leon
    London School of Hygiene and Tropical Medicine, London, UK and Max Planck Institute for Demographic Research, Rostock, Germany
    Addiction 104:1630-6. 2009
    Russia remains in the grip of a mortality crisis in which alcohol plays a central role. In 2007, male life expectancy at birth was 61 years, while for females it was 74 years...
  28. ncbi Age at menopause, cause-specific mortality and total life expectancy
    Marlies E Ossewaarde
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Epidemiology 16:556-62. 2005
    ..The net effect on mortality is unclear. We determined the association of age at menopause with longevity and with the balance between cardiovascular and cancer mortality...
  29. ncbi Insulin-like signaling, nutrient homeostasis, and life span
    Akiko Taguchi
    Howard Hughes Medical Institute, Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Karp Family Research Laboratories, Boston, MA 02115, USA
    Annu Rev Physiol 70:191-212. 2008
    ..We discuss the possibility that the brain is the site where reduced insulin-like signaling can consistently extend mammalian life span-just as reduced insulin-like signaling extends the life span of lower metazoans...
  30. ncbi Life expectancy and cardiovascular mortality in persons with schizophrenia
    Thomas M Laursen
    National Centre for Register Based Research, Aarhus University, Aarhus C, Denmark
    Curr Opin Psychiatry 25:83-8. 2012
    To assess the impact of cardiovascular disease on the excess mortality and shortened life expectancy in schizophrenic patients.
  31. ncbi JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila
    Meng C Wang
    Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
    Dev Cell 5:811-6. 2003
    ..Our work thus identifies the evolutionarily conserved JNK signaling pathway as a major genetic factor in the control of longevity...
  32. pmc The clinical impact and cost-effectiveness of routine, voluntary HIV screening in South Africa
    Rochelle P Walensky
    Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 56:26-35. 2011
    ..Although 900,000 HIV-infected South Africans receive antiretroviral therapy, the majority of South Africans with HIV remain undiagnosed...
  33. pmc Impact of smoking on mortality and life expectancy in Japanese smokers: a prospective cohort study
    R Sakata
    Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    BMJ 345:e7093. 2012
    To investigate the impact of smoking on overall mortality and life expectancy in a large Japanese population, including some who smoked throughout adult life.
  34. pmc Rethinking the evolutionary theory of aging: transfers, not births, shape senescence in social species
    Ronald D Lee
    Department of Demography, University of California, 2232 Piedmont Avenue, Berkeley, CA 94720 2120, USA
    Proc Natl Acad Sci U S A 100:9637-42. 2003
    ..It also explains the evolution of lower fertility, longer life, and increased investments in offspring...
  35. ncbi Blood pressure in adulthood and life expectancy with cardiovascular disease in men and women: life course analysis
    Oscar H Franco
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Hypertension 46:280-6. 2005
    Limited information exists about the consequences of hypertension during adulthood on residual life expectancy with cardiovascular disease...
  36. ncbi Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals
    Ard I van Sighem
    Stichting HIV monitoring, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands
    AIDS 24:1527-35. 2010
    ..To compare life expectancies between recently diagnosed HIV-infected patients and age and sex-matched uninfected individuals from the general population...
  37. ncbi Contribution of major diseases to disparities in mortality
    Mitchell D Wong
    Division of General Internal Medicine and Health Services Research, University of California at Los Angeles, Los Angeles 90095 1736, USA
    N Engl J Med 347:1585-92. 2002
    ..Mortality from all causes is higher for persons with fewer years of education and for blacks, but it is unknown which diseases contribute most to these disparities...
  38. ncbi Life expectancy of patients with newly-diagnosed HIV infection in the era of highly active antiretroviral therapy
    C T Fang
    Department of Internal Medicine, National Taiwan University Hospital, No 7 Chung San South Road, Taipei, Taiwan
    QJM 100:97-105. 2007
    Limited data are available on the life expectancy of patients with newly-diagnosed HIV infection in the era of highly active antiretroviral therapy (HAART).
  39. ncbi Effects of physical activity on life expectancy with cardiovascular disease
    Oscar H Franco
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Arch Intern Med 165:2355-60. 2005
    ..However, little is known about the effects of physical activity on life expectancy with and without cardiovascular disease...
  40. ncbi Widening socioeconomic inequalities in US life expectancy, 1980-2000
    Gopal K Singh
    Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18 41, Rockville, MD 20857, USA
    Int J Epidemiol 35:969-79. 2006
    This study examines changes in the extent of inequalities in life expectancy at birth and other ages in the United States between 1980 and 2000 by gender and socioeconomic deprivation levels.
  41. ncbi Welfare state regimes, infant mortality and life expectancy: integrating evidence from East Asia
    Ying Chih Chuang
    School of Public Health, Taipei Medical University, Taipei, Taiwan
    J Epidemiol Community Health 66:e23. 2012
    ....
  42. pmc The gap in life expectancy from preventable physical illness in psychiatric patients in Western Australia: retrospective analysis of population based registers
    David Lawrence
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, PO Box 855 West Perth WA 6872 Australia
    BMJ 346:f2539. 2013
    ..To examine the mortality experience of psychiatric patients in Western Australia compared with the general population...
  43. ncbi Decomposition of socio-economic differences in life expectancy at birth by age and cause of death among 4 million South Korean public servants and their dependents
    Young Ho Khang
    Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea
    Int J Epidemiol 39:1656-66. 2010
    Differences in life expectancy at birth across social classes can be more easily interpreted as a measure of absolute inequalities in survival...
  44. ncbi Gender differences in life expectancy and disability-free life expectancy among older adults in São Paulo, Brazil
    Flávia Cristina Drumond Andrade
    University of Illinois at Urbana Champaign, Department of Kinesiology and Community Health, Champaign, Illinois 61820, USA
    Womens Health Issues 21:64-70. 2011
    research on life expectancy has demonstrated the negative impact of disability on the health of older adults and its differential effects on women as evidenced by their higher disabled life expectancy (DLE)...
  45. ncbi Compression or expansion of morbidity? Trends in healthy-life expectancy in the elderly Austrian population between 1978 and 1998
    G Doblhammer
    Max Planck Institute for Demographic Research, Rostock, Germany
    Soc Sci Med 52:385-91. 2001
    ..We use self-perceived health ratings to calculate healthy-life expectancy for the elderly population aged 60-89...
  46. pmc Inequalities in premature mortality in Britain: observational study from 1921 to 2007
    Bethan Thomas
    Social and Spatial Inequalities Group, Department of Geography, University of Sheffield, Sheffield S10 2TN
    BMJ 341:c3639. 2010
    ..To report on the extent of inequality in premature mortality as measured between geographical areas in Britain...
  47. ncbi Excess Indigenous mortality: are Indigenous Australians more severely disadvantaged than other Indigenous populations?
    Kenneth Hill
    Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA 02138, USA
    Int J Epidemiol 36:580-9. 2007
    ..Studies indicate that the Indigenous population of Australia suffers a life expectancy disadvantage greater than differentials found in Indigenous populations of other developed countries...
  48. ncbi Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clinical decision making
    Luca Malcovati
    Division of Hematology, IRCCS, Policlinico San Matteo, 27100 Pavia, Italy
    J Clin Oncol 23:7594-603. 2005
    ..of the main prognostic factors in myelodysplastic syndromes (MDSs) classified into WHO subgroups, and to estimate mortality (standardized mortality ratio [SMR]) and life expectancy in these groups as a basis for clinical decision making.
  49. ncbi A model to estimate the lifetime health outcomes of patients with type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68)
    P M Clarke
    Health Economics Research Centre, Department of Public Health, University of Oxford, Headington, Oxford, UK
    Diabetologia 47:1747-59. 2004
    ..a simulation model for type 2 diabetes that can be used to estimate the likely occurrence of major diabetes-related complications over a lifetime, in order to calculate health economic outcomes such as quality-adjusted life expectancy.
  50. pmc Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy
    Simon A Babayan
    Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 8:e1000525. 2010
    ..organisms, should optimize their development and reproduction in response to cues predicting future life expectancy. However, immune-dependent development by helminth parasites has so far eluded such evolutionary explanation...
  51. ncbi Cancer screening in elderly patients: a framework for individualized decision making
    L C Walter
    Division of Geriatrics, VA Medical Center 111G, 4150 Clement St, San Francisco, CA 94121, USA
    JAMA 285:2750-6. 2001
    ..Our framework first anchors decisions through quantitative estimates of life expectancy, risk of cancer death, and screening outcomes based on published data...
  52. ncbi Health, life expectancy, and mortality patterns among immigrant populations in the United States
    Gopal K Singh
    Surveillance Research Program, National Cancer Institute, Division of Cancer Control and Population Sciences, 6116 Executive Blvd, Suite 504, MSC 8316, Bethesda, MD 20892 8316, USA
    Can J Public Health 95:I14-21. 2004
    ..In this study, we examined the extent to which US- and foreign-born blacks, whites, Asians, and Hispanics differ in their health, life expectancy, and mortality patterns across the life course.
  53. pmc The promise of prevention: the effects of four preventable risk factors on national life expectancy and life expectancy disparities by race and county in the United States
    Goodarz Danaei
    Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000248. 2010
    ..We estimated the effects of smoking, high blood pressure, elevated blood glucose, and adiposity on national life expectancy and on disparities in life expectancy and disease-specific mortality among eight subgroups of the US ..
  54. ncbi Mortality trends and setbacks: global convergence or divergence?
    Anthony J McMichael
    National Centre for Epidemiology and Population Health, The Australian National University, Canberra, ACT, Australia 0200
    Lancet 363:1155-9. 2004
    ..In several regions, however, life expectancy has declined over the past 1-2 decades...
  55. pmc Racial and sex disparities in life expectancy losses among HIV-infected persons in the united states: impact of risk behavior, late initiation, and early discontinuation of antiretroviral therapy
    Elena Losina
    Divisions of General Medicine, Department of Medicine, MA 02114, USA
    Clin Infect Dis 49:1570-8. 2009
    ....
  56. ncbi The naked mole-rat: a new long-living model for human aging research
    Rochelle Buffenstein
    Department of Biology, City College of CUNY, Convent Ave at 138th St, New York, NY 10031, USA
    J Gerontol A Biol Sci Med Sci 60:1369-77. 2005
    ..Young naked mole-rats surprisingly have high levels of accrued oxidative damage. With their similar longevity quotient to humans, these rodents may provide a novel opportunity to examine mechanisms modulating aging...
  57. ncbi Social capital, life expectancy and mortality: a cross-national examination
    Brendan Kennelly
    Department of Economics, The National University of Ireland, Galway, Ireland
    Soc Sci Med 56:2367-77. 2003
    ..The paper casts doubt upon the widely accepted hypothesis that social capital has a positive effect on health and illustrates the importance of testing this kind of hypothesis in an extended model...
  58. pmc The changing relation between education and life expectancy in central and eastern Europe in the 1990s
    Vladimir M Shkolnikov
    Max Planck Institute for Demographic Research, Rostock, Germany
    J Epidemiol Community Health 60:875-81. 2006
    ..in central and eastern Europe has been generally associated with widening educational differences in life expectancy. However, interpretation of these findings is complicated because the size of educational categories within ..
  59. ncbi The evolving pattern of avoidable mortality in Russia
    Evgueni M Andreev
    Laboratory of Analysis and Prognosis of Population Mortality, Centre of Demography and Human Ecology, Institute of Economic Forecasting, Russian Academy of Sciences, 47 Nakhimovsky Prospect, 117418 Moscow, Russian Federation
    Int J Epidemiol 32:437-46. 2003
    b>Life expectancy at birth in Russia is over 12 years less than in western Europe...
  60. ncbi Decomposition of differences in health expectancy by cause
    Wilma J Nusselder
    Department of Public Health, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Demography 41:315-34. 2004
    ..This method is an extension of the decomposition method for life expectancy developed by Arriaga...
  61. ncbi Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infection
    Sue J Goldie
    Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115 5924, USA
    Am J Med 115:632-41. 2003
    ..To explore the cost-effectiveness of interventions to improve adherence to combination antiretroviral therapy in patients with human immunodeficiency virus (HIV) infection...
  62. ncbi Disability life expectancy for the elderly, city of Sao Paulo, Brazil, 2000: gender and educational differences
    Mirela Castro Santos Camargos
    Departamento de Demografia, CEDEPLAR, UFMG, Minas Gerais, Brazil
    J Biosoc Sci 39:455-63. 2007
    There is evidence that 'health life expectancy' (expected number of years to be lived in health) differs by socioeconomic status. Time spent in health or disability plays a critical role in the use of health care services...
  63. ncbi Impact of HAART and injection drug use on life expectancy of two HIV-positive cohorts in British Columbia
    Elisa Lloyd-Smith
    Department of Health Care and Epidemiology, University of British Columbia, Vancouver, British Columbia, Canada
    AIDS 20:445-50. 2006
    ..However, there is evidence that not all populations have benefited equally from HAART and that mortality rates are higher in HIV-infected injection drug users than in non-users...
  64. ncbi Cost-effectiveness of HIV treatment in resource-poor settings--the case of Côte d'Ivoire
    Sue J Goldie
    Department of Health Policy and Management, Program in Health Decision Science, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 355:1141-53. 2006
    ..As antiretroviral therapy is increasingly used in settings with limited resources, key questions about the timing of treatment and use of diagnostic tests to guide clinical decisions must be addressed...
  65. ncbi Life expectancy living with HIV: recent estimates and future implications
    Fumiyo Nakagawa
    Research Department of Infection and Population Health, UCL, London, UK
    Curr Opin Infect Dis 26:17-25. 2013
    The life expectancy of people living with HIV has dramatically increased since effective antiretroviral therapy has been available, and still continues to improve...
  66. ncbi Successful deinstitutionalization of mental health care: increased life expectancy among people with mental disorders in Finland
    Jeanette Westman
    Nordic School of Public Health, Gothenburg, Sweden
    Eur J Public Health 22:604-6. 2012
    To assess impact of deinstitutionalization of mental health care, we studied life expectancy for 341 630 people with hospitalization or early retirement pension for mental disorders in 1981-2003 in Finland...
  67. pmc The impact of functional status on life expectancy in older persons
    Emmett Keeler
    Multicampus Program in Geriatric Medicine and Gerontology, Division of Geriatrics, Department of Medicine, David Geffen School of Medicine at UCLA, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA 90095 1687
    J Gerontol A Biol Sci Med Sci 65:727-33. 2010
    ..Inclusion of functional status may permit more precise prognostic estimates of life expectancy and proportion of time in various functional states.
  68. pmc Understanding the rapid increase in life expectancy in South Korea
    Seungmi Yang
    Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada
    Am J Public Health 100:896-903. 2010
    We assessed life expectancy increases in the past several decades in South Korea by age and specific causes of death.
  69. ncbi The relationship between health and GDP in OECD countries in the very long run
    Robyn Swift
    Griffith Business School, Griffith University, Brisbane, Queensland, Australia
    Health Econ 20:306-22. 2011
    ..A similar, long run, cointegrating relationship between life expectancy and both total GDP and GDP per capita was found for all the countries estimated...
  70. ncbi Quality-adjusted life expectancy (QALE) and loss of QALE for patients with ischemic stroke and intracerebral hemorrhage: a 13-year follow-up
    Hsin Yi Lee
    Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan
    Stroke 41:739-44. 2010
    ..The aim of this study is to quantify the loss of quality-adjusted life expectancy related to ischemic stroke and intracerebral hemorrhage.
  71. ncbi Dementia and life expectancy: what do we know?
    Michelle Lee
    David Geffen School of Medicine, UCLA, Division of Geriatric Medicine, Los Angeles, CA 90095, USA
    J Am Med Dir Assoc 10:466-71. 2009
    ..Dementia is a common geriatric syndrome. It is unclear how best to predict survival among dementia patients, which leaves clinicians, patients, and families uncertain as to how to proceed with medical decisions and reassessing goals...
  72. ncbi The physical activity transition
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Perkins Rd, Baton Rouge, LA 70808, USA
    J Phys Act Health 6:269-80. 2009
    ..and to explore the potential effects that declining physical activity levels may play on health and life expectancy as countries undergo economic and demographic changes...
  73. ncbi The influence of subjective life expectancy on health state valuations using a 10 year TTO
    F E van Nooten
    Department of Health Policy and Management, Erasmus University Rotterdam Erasmus MC, Rotterdam, The Netherlands
    Health Econ 18:549-58. 2009
    To investigate if subjective life expectancy (SLE) impacts the willingness to trade-off (WTT) and the number of years traded-off in a 10-years time trade-off (TTO) exercise to obtain health state valuations.
  74. pmc The aging process and potential interventions to extend life expectancy
    Matteo Tosato
    Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Rome, Italy
    Clin Interv Aging 2:401-12. 2007
    ..Nevertheless, several studies on animal models have shown that aging rates and life expectancy can be modified...
  75. pmc Higher education delays and shortens cognitive impairment: a multistate life table analysis of the US Health and Retirement Study
    Mieke Reuser
    Netherlands Interdisciplinary Demographic Institute NIDI, The Hague, The Netherlands
    Eur J Epidemiol 26:395-403. 2011
    ..The effect of education is more pronounced among ethnic minorities. Higher life expectancy goes together with a longer period of cognitive impairment, but not for higher levels of education: that ..
  76. ncbi The aftershock of deindustrialization--trends in mortality in Scotland and other parts of post-industrial Europe
    David Walsh
    Glasgow Centre for Population Health, Glasgow, Scotland, UK
    Eur J Public Health 20:58-64. 2010
    ..This begs the question: to what extent is poor health a common outcome in other post-industrial regions and how does Scotland's experience compare to these other comparable regions?..
  77. ncbi What has made the population of Japan healthy?
    Nayu Ikeda
    Department of Global Health Policy, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Lancet 378:1094-105. 2011
    People in Japan have the longest life expectancy at birth in the world. Here, we compile the best available evidence about population health in Japan to investigate what has made the Japanese people healthy in the past 50 years...
  78. pmc Life expectancies and incidence rates of patients under prolonged mechanical ventilation: a population-based study during 1998 to 2007 in Taiwan
    Mei Chuan Hung
    Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, No 17, Xuzhou Road, Taipei 100, Taiwan
    Crit Care 15:R107. 2011
    ..The present study examined the median survival, life expectancies, and cumulative incidence rate (CIR) of patients undergoing prolonged mechanical ventilation (PMV) stratified by different underlying diseases...
  79. pmc Contribution of obesity to international differences in life expectancy
    Samuel H Preston
    University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Public Health 101:2137-43. 2011
    ..The United States has the highest prevalence of obesity and one of the lowest life expectancies among high-income countries. We investigated the relationship between these 2 phenomena...
  80. ncbi The free radical theory of aging
    Denham Harman
    University of Nebraska College of Medicine, Department of Medicine, Omaha, NE 68198 4635, USA
    Antioxid Redox Signal 5:557-61. 2003
    ..Aging changes may be caused by free radical reactions. The extensive studies based on this possibility hold promise that the ALE-B can be extended to >85 years and the maximum life span increased...
  81. ncbi Managing cystic fibrosis: strategies that increase life expectancy and improve quality of life
    Malena Cohen-Cymberknoh
    Department of Pediatrics and CF Center, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Am J Respir Crit Care Med 183:1463-71. 2011
    ..The purpose of this review is to survey recent developments in CF care that are responsible for the improved survival and quality of life of patients with CF...
  82. ncbi Brain stem metastases treated with radiosurgery: prognostic factors of survival and life expectancy estimation
    José G Lorenzoni
    Department of Neurosurgery, Hopital Erasme, Gamma Knife Center, Universite Libre de Bruxelles, 1000 Brussels, Belgium
    Surg Neurol 71:188-95; discussion 195, 195-6. 2009
    The objective of this study is to study prognostic factors of survival and 3 stratification systems for life expectancy estimation in patients with brain stem metastases treated with radiosurgery.
  83. ncbi Vitamin E may affect the life expectancy of men, depending on dietary vitamin C intake and smoking
    Harri Hemilä
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Age Ageing 40:215-20. 2011
    ..antioxidants might protect against oxidative stress, which has been suggested as a cause of aging...
  84. pmc Geographical variation in life expectancy at birth in England and Wales is largely explained by deprivation
    Laura M Woods
    Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    J Epidemiol Community Health 59:115-20. 2005
    To describe the population mortality profile of England and Wales by deprivation and in each government office region (GOR) during 1998, and to quantify the influence of geography and deprivation in determining life expectancy.
  85. ncbi The cost effectiveness of combination antiretroviral therapy for HIV disease
    K A Freedberg
    Division of General Internal Medicine and the Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    N Engl J Med 344:824-31. 2001
    ..We estimated the clinical benefits and cost effectiveness of three-drug antiretroviral regimens...
  86. ncbi Adult obesity and the burden of disability throughout life
    Anna Peeters
    Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
    Obes Res 12:1145-51. 2004
    To analyze the prevalence of disability throughout life and life expectancy free of disability, associated with obesity at ages 30 to 49 years.
  87. ncbi Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy
    Viviane D Lima
    BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
    AIDS 21:685-92. 2007
    To characterize the temporal changes in mortality and life expectancy among HIV-positive individuals initiating antiretroviral therapy in British Columbia, Canada, from 1993 to 2004.
  88. ncbi Premature mortality from general medical illnesses among persons with bipolar disorder: a review
    Babak Roshanaei-Moghaddam
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, USA
    Psychiatr Serv 60:147-56. 2009
    ..The authors reviewed the literature to determine whether there is evidence of increased risk of mortality from general medical causes among patients with bipolar spectrum disorders...
  89. ncbi Association between benign and malignant peripheral nerve sheath tumors in NF1
    T Tucker
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Neurology 65:205-11. 2005
    ..The authors conducted a study to determine whether people with NF1 who have benign neurofibromas of various kinds are at greater risk of developing MPNSTs than patients with NF1 who lack these benign tumors...
  90. ncbi Life expectancy after HIV diagnosis based on national HIV surveillance data from 25 states, United States
    Kathleen McDavid Harrison
    Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 53:124-30. 2010
    We estimate life expectancy and average years of life lost (AYLL) after an HIV diagnosis using population-based surveillance data from 25 states that have had name-based HIV surveillance since 1996.
  91. ncbi The Global Activity Limitation Index measured function and disability similarly across European countries
    Carol Jagger
    Department of Health Sciences, University of Leicester, Leicester, United Kingdom
    J Clin Epidemiol 63:892-9. 2010
    ..This work aims to validate and increase understanding of the Global Activity Limitation Index (GALI), an activity limitation measure from which the new structural indicator Healthy Life Years is generated...
  92. ncbi Smoking kills, obesity disables: a multistate approach of the US Health and Retirement Survey
    Mieke Reuser
    Netherlands Interdisciplinary Demographic Institute, The Hague, The Netherlands
    Obesity (Silver Spring) 17:783-9. 2009
    ..9), nonsmoking and high education. Mild obesity (BMI: 30-34.9) did not change total life expectancy (LE) but exchanged disabled for disability-free years. Mild obesity decreased disability-free LE with 2...
  93. ncbi Survival in Duchenne muscular dystrophy: improvements in life expectancy since 1967 and the impact of home nocturnal ventilation
    Michelle Eagle
    Newcastle Muscle Centre, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Neuromuscul Disord 12:926-9. 2002
    ..4 years, whereas for those ventilated since 1990 it was 25.3 years. Cardiomyopathy significantly shortened life expectancy from 19 years to a mean age of 16.9 years...
  94. pmc Infant mortality rate as an indicator of population health
    D D Reidpath
    School of Health Sciences, Deakin University, Burwood, Australia
    J Epidemiol Community Health 57:344-6. 2003
    ..More comprehensive measures such as disability adjusted life expectancy (DALE) have come into favour as alternatives...
  95. ncbi Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
    Kevin J Bitterman
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:45099-107. 2002
    ..We discuss the possibility that nicotinamide is a physiologically relevant regulator of Sir2 enzymes...
  96. pmc Mortality in neurofibromatosis 1: an analysis using U.S. death certificates
    S A Rasmussen
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Hum Genet 68:1110-8. 2001
    ..46-3.32 at 20-29 years) but not in older persons. This study supports previous findings of decreased life expectancy for persons with NF1 and, within the limitations of death certificates, provides population-based data about ..
  97. ncbi Years of life lost due to obesity
    Kevin R Fontaine
    Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    JAMA 289:187-93. 2003
    ..Public health officials and organizations have disseminated health messages regarding the dangers of obesity, but these have not produced the desired effect...
  98. pmc Puzzles, promises and a cure for ageing
    Jan Vijg
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA
    Nature 454:1065-71. 2008
    ..A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect...
  99. pmc What is successful ageing and who should define it?
    Ann Bowling
    Department of Primary Care and Population Sciences, University College London, London NW3 2PF
    BMJ 331:1548-51. 2005
  100. ncbi Schizophrenia and increased risks of cardiovascular disease
    Charles H Hennekens
    Department of Biomedical Science, Center of Excellence in Biomedical and Marine Biotechnology, Florida Atlantic University, FL, USA
    Am Heart J 150:1115-21. 2005
    ..The aim of the study is to review the absolute and relative impacts of the major causes for premature mortality among patients with schizophrenia...

Research Grants77

  1. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Owing to the increase in obesity, life expectancy may start to decrease in developed countries for the first time...
  2. Role of JAK2-PAK1 interaction in prolactin-dependent signaling
    Maria Diakonova; Fiscal Year: 2013
    ..Based on the current life expectancy for women in the United States, 1 out of 9 women will develop breast cancer in her lifetime - a risk that was ..
  3. Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret Model
    Zoe Stewart; Fiscal Year: 2013
    ..patients, pancreatic disease leads to diabetes mellitus in up to 50% of adult patients, resulting in reduced life expectancy. Progress in elucidating the pathophysiology of CFRD has been hindered by the lack of an animal model. Dr...
  4. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..With increasing life expectancy and aging baby-boomer generation, the estimated future costs of treatment and elderly patient care, and its ..
  5. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2010
    Owing to the increase in obesity, life expectancy may start to decrease in developed countries for the first time. Environmental factors are increasingly found to be associated with the development of obesity...
  6. Role of TPH2 and 5HT Neuronal Loss in Non-motor Symptoms of Parkinson's
    Donald M Kuhn; Fiscal Year: 2012
    ..L-DOPA-induced, are not trivial and contribute to worsened disability, impaired quality of life and shortened life expectancy. Therefore, a better understanding of the mechanisms responsible for the non-motor symptoms that accompany ..
  7. The Role of Alcohol in HIV Therapy Hepatotoxicity
    Craig J McClain; Fiscal Year: 2012
    ..Since the introduction of highly active antiretroviral therapy (HAART) in 1996, the life expectancy of patients with HIV has increased significantly...
  8. A dataset for the study of the social determinants of health.
    Peter A Muennig; Fiscal Year: 2010
    ..me fairly," as having a racial component), and, finally, a means for translating mortality differences into life expectancy differences so that the policy implications of researchers'findings can be more easily understood...
  9. Regulation of Metabolism by Dietary Sterols
    SHAILENDRA BHANUBHAI PATEL; Fiscal Year: 2013
    ..We show that Abcg8 knockout mice, exposed to a plant sterol diet, have significantly reduced life expectancy, are infertile and manifest reduced adipose tissue stores...
  10. Developmental Origins of Phenotypic Characteristics that Predict Longevity
    Andrzej Bartke; Fiscal Year: 2012
    ..And what early lifestyle and/or pharmacological interventions could effectively increase healthspan and life expectancy? PUBLIC HEALTH RELEVANCE: There is considerable evidence that growth hormone (GH) and other hormones that ..
  11. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2012
    ..RELEVANCE: Neurodegenerative diseases are major and increasing health threats as a result of the increased life expectancy and aging population in the United States...
  12. Autophagy and human islet amyloid polypeptide in animal models of type 2 diabetes
    Jacqueline Rivera; Fiscal Year: 2013
    ..In people with type 2 diabetes there is a shortened life expectancy through vascular complications as well as an increased risk of several cancers...
  13. Cardiometabolic Risk Factors and Obesity in Adolescents with Down Syndrome
    Sheela Natesh Magge; Fiscal Year: 2013
    ..With a life expectancy of 60 years, individuals with Down syndrome are in need of health care that is preventative, evidence-based, ..
  14. CANCER AND CHANGING TRENDS IN US MORTALITY INEQUITIES: 1960-2004
    Nancy Krieger; Fiscal Year: 2010
    ..research on trends in socioeconomic health inequities has focused on such outcomes as all-cause mortality, life expectancy, or infant mortality, with analyses typically extending back only to the 1980s...
  15. Development of Inhaled Vancomycin for Treatment of MRSA Infections in CF
    Taneli Jouhikainen; Fiscal Year: 2012
    ..infections, which are prevalent in 40-50% of CF patients, and have been shown to be associated with a shorter life expectancy compared to CF patients without MRSA...
  16. AREA: Rapamycin, ambient temperature, and longevity
    Steven J Swoap; Fiscal Year: 2010
    ....
  17. The altered lipid and protein metabolism of pediatric patients with HIV infection
    Farook Jahoor; Fiscal Year: 2010
    ..therapy (HAART) has markedly reduced the morbidity and mortality of HIV- infected children, the improved life expectancy is associated with a complex set of metabolic disorders in a subset of patients...
  18. Control of HIV drug resistance in older patients
    Alonso Heredia; Fiscal Year: 2010
    Highly active antiretroviral therapy (HAART) has dramatically increased life expectancy in HIV infection and by 2015 more than half of HIV patients in the U.S. will be older than 50...
  19. Regulated Transgene Expression in the Retina
    James M Wilson; Fiscal Year: 2010
    ..disease is a major cause for visual disability among persons over 60 years of age that with the increase in life expectancy is not only a medical problem but also one with a significant socio-economic impact...
  20. Rapid Heart Attack Detection using an AC Electrokinetic Device
    Rajaram Krishnan; Fiscal Year: 2011
    ..Moreover, this trend is expected to dramatically worsen given global life expectancy increases, population growth, and the rapidly escalating prevalence of obesity and diabetes...
  21. Biology of Aerobic Capacity and Insulin Resistance
    Charles F Burant; Fiscal Year: 2012
    ..Indeed, oxidative capacity is an excellent predictor of life expectancy. Decreases in skeletal muscle mitochondrial oxidative phosphorylation can be found in individuals who are ..
  22. Mechanisms of mitochondrial fission/fusion dysregulation during HIV-1-associated
    JEREL ADAM FIELDS; Fiscal Year: 2013
    ..Moreover, HAART increases life expectancy and an increasingly large pool of HIV patients are managing viral infection confounded by processes of aging...
  23. Humanization of hFcRn Mice for Physiological Evaluation of Therapeutic Antibodies
    MICHAEL VAN WILES; Fiscal Year: 2013
    ..We fully expect these models to more accurately reflect human IgG and human albumin biology and, therefore, rapidly advance drug development and FcRn biology. ..
  24. Identification of Mammalian Genes Promoting Life Extension
    SIU HUNG CHICK; Fiscal Year: 2013
    ..We anticipate that the insights gained from these studies will foster a variety of new directions for aging research. ..
  25. Measles Virotherapy and radiovirotherapy in the Treatment of recurrent gliomas
    Evanthia Galanis; Fiscal Year: 2013
    ..gliomas are responsible for a disproportionate amount of morbidity, in addition to significant reduction in life expectancy. In preclinical models, measles vaccine strains have potent antitumor activity against gliomas and ..
  26. Exploring the Role of the Brain Epigenome: Cognitive Decline and Life Experiences
    David Alan Bennett; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): As a result of declining fertility and increasing life expectancy, the 21st century will continue to witness the remarkable increase in the number and proportion of older persons that began in the ..
  27. Drak2-A Potential Therapeutic Target for Type 1 Diabetes
    Blaine Creasy; Fiscal Year: 2010
    ..S. Improved therapies to treat diabetes would greatly enhance the quality and life expectancy for the millions who suffer from this devastating disease...
  28. Sleep and Cardiovascular Health
    Phyllis C Zee; Fiscal Year: 2012
    DESCRIPTION (provided by investigator): With increase in life expectancy, there has also been a parallel increase in chronic co- morbidities that impair functional status and quality of life in older age...
  29. Multi-Dimensional Successful Aging Among HIV-Infected Adults
    David J Moore; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The life expectancy of adults receiving antiretroviral therapy (ART) has been increasing progressively. By 2015 one-half of HIV+ people in the U.S...
  30. Omega-3 Fatty Acid Administration In Dialysis Patients
    Talat Alp Ikizler; Fiscal Year: 2010
    ..There are currently more than 300,000 patients receiving chronic dialysis therapy in the United States and the life expectancy for these patients are only 1/3 to 1/6 of those for the general population...
  31. IL-15 Superagonist Complex as an Immunotherapeutic for Multiple Myeloma
    Hing C Wong; Fiscal Year: 2012
    ..The number of geriatric MM patients is expected to increase over time because of the increasing life expectancy of the normal population...
  32. Comparative Effectiveness of Post-Discharge Strategies for Hospitalized Smokers
    Nancy A Rigotti; Fiscal Year: 2013
    ..S. Smoking cessation reduces risk and extends life expectancy. This project aims to identify a cost-effective strategy for delivering smoking cessation treatment to the ..
  33. LIPOLYSIS AND OLEOYLETHANOLAMIDE SIGNALING IN THE REGULATION OF LONGEVITY
    ANDREW K FOLICK; Fiscal Year: 2013
    ....
  34. Pediatric Nephrology Seminar XXXIX
    GASTON E ZILLERUELO; Fiscal Year: 2012
    ..This is consistent with the Healthy People 2010 goal of helping individuals of all ages increase life expectancy and improve their quality of life, specifically in the areas of maternal, infant and child health.
  35. Comparative Effectiveness of Dialysis Modalities
    Rajnish Mehrotra; Fiscal Year: 2013
    ....
  36. MHC class II-Associated Endothelial Dysfunction
    Joseph Holoshitz; Fiscal Year: 2010
    ..The results of this study could shed much needed light on a disease that shortens life expectancy of rheumatoid arthritis patients and could identify novel targets for future therapy.
  37. Immune determinants of adaptive thermogenesis
    Ajay Chawla; Fiscal Year: 2013
    ..In addition to its impact on disease and life expectancy, the medical care costs of obesity in the United States are staggering, exceeding $147 billion in 2008...
  38. Studying a bone marrow failure disease using patient-specific iPS cells
    LUIS ZIRNBERGER BATISTA; Fiscal Year: 2013
    ..patients suffering with dyskeratosis congenita (DC), a bone-marrow failure syndrome that presents with poor life expectancy and multi-systemic tissue defects that include aplastic anemia and pulmonary fibrosis...
  39. Pediatric Cancer, Family Conflict and Child Adjustment
    Lynn Fainsilber Katz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): With the improved life expectancy of most children with cancer, attention has been turned to improving the quality of life of cancer survivors and their family members...
  40. Anti-biofilm agents for treating pulmonary infection in Cystic Fibrosis patients
    LAURA MICHELLE GUOGAS; Fiscal Year: 2011
    ..An improved treatment for CF has the potential to both extend the life expectancy and improve the quality of life for the hundreds of thousands of individuals worldwide who are living with CF. ..
  41. The Down Syndrome Growing Up Study
    Babette S Zemel; Fiscal Year: 2012
    ..S. children with DS are available but outdated. Advances in health care and improved life expectancy of children with DS have occurred in the past few decades, and there is a well- recognized need for revised ..
  42. METABOLISM OF THE VLDL RECEPTOR AND APOE RECEPTOR 2
    JOACHIM J HERZ; Fiscal Year: 2013
    ....
  43. Neuroprotective Gene Therapy in the Brain of Senile Rats
    Rodolfo G Goya; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The increase in life expectancy achieved by modern medicine has led to a progressive rise in the incidence of age-related neurodegenerative ..
  44. Improving the Kinetics and Reliability of Continuous Glucose Monitoring
    Brett D Mensh; Fiscal Year: 2012
    ..with type 1 diabetes mellitus (T1DM) will experience dramatic improvements in their quality of life and life expectancy when the goal of engineering an artificial pancreas is finally realized...
  45. CFFONE: A Cell Phone Support Program for Adolescents with Cystic Fibrosis
    KEVIN F DAWKINS; Fiscal Year: 2010
    ..With cutting-edge research spurring medical advances, each decade has shown improved survival, from a median life expectancy of 5 years in 1960, to 16 years in 1970, to 35 years today...
  46. Muscularization of pulmonary arteries induced by an adaptive immune response
    Gabriele Grunig; Fiscal Year: 2010
    ..hypertension (PAH) is a devastating condition because of its deleterious impact on quality of life, and life expectancy. Clinical correlation studies have suggested an immune pathogenesis because of the increased incidence of PAH ..
  47. Rewarding experience and the aging brain
    Erica R Glasper; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: the mean life expectancy is extended due to advances in modern science and medicine, many concerns regarding the physical and mental ..
  48. Akt/CREB signaling: Target for prostate cancer
    Addanki P Kumar; Fiscal Year: 2013
    ..In addition with increasing life expectancy of the Veteran population, prostate cancer will continue to be a major health problem...
  49. Therapeutic correction of deltaF508-CFTR cystic fibrosis by a novel PDZ12 drug.
    Alvin Bach; Fiscal Year: 2013
    ..CF patients have a life expectancy of 37 years and need intensive therapeutic interventions for chronic co-morbidities and symptoms...
  50. CVD in American Indians: Imaging and Cardiovascular Center
    Richard B Devereux; Fiscal Year: 2013
    ..Secular trends, life expectancy, the effects of renal disease on preclinical CVD, and the role of preclinical measures in predicting CVD ..
  51. CVD in American Indians Study and Data Management Center and OK Field Center
    ELISA TAN LEE; Fiscal Year: 2013
    ..Secular trends, life expectancy, the effects of renal disease on preclinical CVD, and the role of preclinical measures in predicting CVD ..
  52. Gene Transfer for Recessive Dystrophic Epidermolysis Bullosa
    MATT PETER MARINKOVICH; Fiscal Year: 2013
    ..RDEB subjects have a shortened life expectancy with early death from infection, organ failure or squamous cell carcinoma (SCC)...
  53. Environmental Attributes and Weight Control: Study of Over 1.3 Million Veterans
    Shannon N Zenk; Fiscal Year: 2013
    ..S. medical spending, and conservatively accounts for 30% of the gap in life expectancy between Americans and their counterparts in 13 other high-income countries...
  54. Health Promotion and Fitness for Younger and Older Adults With SMI
    Stephen J Bartels; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Adults with serious mental illness (SMI) have a 20 percent reduced life expectancy and disproportionately greater prevalence of medical comorbidity associated with high rates of obesity, sedentary ..
  55. A Caribbean Project for Clinical and Basic Neuroscience Research
    EDMUNDO NELSON KRAISELBURD; Fiscal Year: 2011
    ..Neurological complications of HIV are becoming more evident with advances in the treatment and extended life expectancy of HIV-infected patients...
  56. Systems Biology for Studies of Cognition in Down Syndrome
    Katheleen Gardiner; Fiscal Year: 2012
    The incidence of Down syndrome (DS) is one in 700 live births, the life expectancy is now >50 years, and the average IQ is approximately 50. Therefore, DS is a significant social and medical issue...
  57. Human Gene Knockdowns that May Extend Lifespan
    Cynthia J Kenyon; Fiscal Year: 2013
    ..This fresh approach will define new potential drug targets for extending the youthful and productive years of human life, and for delaying age-related diseases such as cancer, heart disease and/or neurodegenerative disease. ..
  58. Metabolic Screening: Prioritizing Implementation Strategies for Mental Health
    Elaine H Morrato; Fiscal Year: 2013
    ..with serious mental illness, excess cardiovascular risk contributes to decades of reduced life expectancy. Physicians prescribing second-generation antipsychotics (SGA) will be studied to focus the analysis because ..
  59. Randomized Trial of Achieving Healthy Lifestyles in Psych Rehabilitation
    Gail L Daumit; Fiscal Year: 2012
    ..conditions likely contribute substantially to premature cardiovascular disease and the 20 percent shortened life expectancy in SMI...
  60. ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORK
    Anna Barbara Moscicki; Fiscal Year: 2001
    ..With the increased life expectancy of HIV infected persons, the rates of anogenital cancers can be expected to continue to rise...
  61. Novel Molecular and Cellular Therapies in Fanconi Anemia
    David Williams; Fiscal Year: 2009
    ..This grant proposal seeks funding to conduct these clinical trials and further develop retrovirus-mediated complementation analysis in a CAP/CLIA environment for use in clinical management of FA patients. ..
  62. Open-Source Informatics Used to Improve Outcomes in Pediatric Liver Transplants
    STEVEN PETER BUCUVALAS; Fiscal Year: 2010
    ..the same two-year old can receive a liver transplant and, with ongoing treatment, a potentially normal life expectancy. Some 500 children undergo pediatric liver transplantation (PLT) annually in the U.S...
  63. The Treatment of Methotrexate Resistant Rheumatoid Arthritis With Aminopterin
    Stuart Kahn; Fiscal Year: 2009
    ..of the population, and is associated with progressive joint destruction, functional disability and decreased life expectancy. Methotrexate (MTX), an antifolate used alone or in combination with other medicines, is the current mainstay ..
  64. Viscoelastic deformation of bone matrix in postmenopause
    Do Gyoon Kim; Fiscal Year: 2010
    ..These types of fractures will likely become more common as human life expectancy increases...
  65. The UAB Spina Bifida Patient Registry Demonstration Project
    David B Joseph; Fiscal Year: 2010
    ..to new medical treatments and technology, most people born with Spina Bifida can expect to live a normal life expectancy. Those with this challenging birth defect are living longer, more productive lives than was dreamed of just ..
  66. Development of a National Incompatible Kidney Transplant Registry
    Robert A Montgomery; Fiscal Year: 2010
    ..Live donor kidney transplantation is the best treatment for kidney failure, doubling life expectancy and significantly improving quality of life...
  67. Pharmacogenetics of Methotrexate Therapy in Arthritis
    ALEXANDER WHITEHEAD; Fiscal Year: 2006
    ..provided by applicant): Inflammatory diseases, including arthritis, are often associated with reduced life expectancy, due in part to an excess of cardiovascular disease deaths...
  68. Effectiveness of Early Stage Prostate Cancer Treatment
    MARTIN G contact SANDA; Fiscal Year: 2010
    ..of prostate cancer treatment has been previously evaluated by Markov models to measure Quality-adjusted Life Expectancy (QALE), but these comparisons did not use prospectively collected HRQOL outcome data to assign transition ..
  69. Guideline Adherence and Health Outcomes in Medicare FFS Patients with Diabetes
    Maureen Smith; Fiscal Year: 2009
    ..increased risks have even more significance if the benefits of tight control are limited due to shortened life expectancy. If the long-term benefits are not relevant and the short-term risks are significant, there may be little ..
  70. NHLBI MINORITY INSTITUTION RESEARCH SCIENTIST DEVELOPMEN
    MARIA DEL PILAR AGUINAGA; Fiscal Year: 2004
    ..anemia with recurrent vasoocclusive episodes, secondary complications, impaired quality of life and a reduced life expectancy. Sickle cell disease is caused by the substitution of glutamic acid with valine at the position of amino acid ..
  71. CFFONE: A Cell Phone Support Program for Teens with Cystic Fibrosis
    Kevin Dawkins; Fiscal Year: 2007
    ..With cutting-edge research spurring medical advances, each decade has shown improved survival, from a median life expectancy of 5 years in 1960, to 16 years in 1970, to 35 years today...
  72. CLONING OF FAMILIAL PRIMARY PULMONARY HYPERTENSION GENE
    William Nichols; Fiscal Year: 2006
    ..Definitive diagnosis requires cardiac catheterization. Average life expectancy after diagnosis is now more than 2 to 3 years with the development of new treatments in recent years...
  73. Quantifying altered hemodynamics in response to stenting for aortic coarctation
    JOHN LADISA; Fiscal Year: 2009
    ..Although excellent treatments for CoA exist, life expectancy is substantially reduced and long-term problems including hypertension often develop...
  74. COST-EFFECTIVE MANAGEMENT OF HIV-RELATED ILLNESSES
    Anna Tosteson; Fiscal Year: 1991
    ..Our CNS model will assess the life-expectancy, quality-adjusted life expectancy, short term morbidity, cost, and cost-effectiveness of all clinically reasonable management strategies in ..