Genomes and Genes
Summary: A figure representing the number of years, based on known statistics, to which any person of a given age may reasonably expect to live.
Publications392 found, 100 shown here
- Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancyI Min Lee
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Lancet 380:219-29. 2012..diseases such as coronary heart disease, type 2 diabetes, and breast and colon cancers, and shortens life expectancy. Because much of the world's population is inactive, this link presents a major public health issue...
- Increases in adult life expectancy in rural South Africa: valuing the scale-up of HIV treatmentJacob Bor
Africa Centre for Health and Population Studies, University of KwaZulu Natal, Post Office Box 198, Mtubatuba, KwaZulu Natal 3935, South Africa
Science 339:961-5. 2013The scale-up of antiretroviral therapy (ART) is expected to raise adult life expectancy in populations with high HIV prevalence...
- Healthy life expectancy for 187 countries, 1990-2010: a systematic analysis for the Global Burden Disease Study 2010Joshua A Salomon
Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
Lancet 380:2144-62. 2012Healthy life expectancy (HALE) summarises mortality and non-fatal outcomes in a single measure of average population health. It has been used to compare health between countries, or to measure changes over time...
- Minimum amount of physical activity for reduced mortality and extended life expectancy: a prospective cohort studyChi Pang Wen
Institute of Population Science, National Health Research Institutes, Zhunan, Taiwan
Lancet 378:1244-53. 2011..physical activity are well known, but whether less exercise than the recommended 150 min a week can have life expectancy benefits is unclear...
- A potential decline in life expectancy in the United States in the 21st centuryS Jay Olshansky
University of Illinois at Chicago, Chicago 60612, USA
N Engl J Med 352:1138-45. 2005Forecasts of life expectancy are an important component of public policy that influence age-based entitlement programs such as Social Security and Medicare...
- Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) StudyMargaret May
School of Social and Community Medicine, Bristol University, Bristol BS8 2PS, UK
BMJ 343:d6016. 2011To estimate life expectancy for people with HIV undergoing treatment compared with life expectancy in the general population and to assess the impact on life expectancy of late treatment, defined as CD4 count <200 cells/mm(3) at start ..
- Demography. Broken limits to life expectancyJim Oeppen
Cambridge Group for the History of Population and Social Structure, Cambridge University, Cambridge, CB2 3EN, UK
Science 296:1029-31. 2002
- Survival of persons with and without HIV infection in Denmark, 1995-2005Nicolai Lohse
Department of Infectious Diseases, Odense University Hospital and University of Southern Denmark, Odense, Denmark
Ann Intern Med 146:87-95. 2007..The expected survival of HIV-infected patients is of major public health interest...
- Life expectancy of persons receiving combination antiretroviral therapy in low-income countries: a cohort analysis from UgandaEdward J Mills
University of Ottawa, Ottawa, Ontario, Canada
Ann Intern Med 155:209-16. 2011Little is known about the effect of combination antiretroviral therapy (cART) on life expectancy in sub-Saharan Africa.
- Life expectancy at birth for people with serious mental illness and other major disorders from a secondary mental health care case register in LondonChin Kuo Chang
King s College London Institute of Psychiatry, London, United Kingdom
PLoS ONE 6:e19590. 2011..The electronic database from a large and comprehensive secondary mental healthcare provider in London was utilized to assess the impact of SMI diagnoses on life expectancy at birth.
- Life expectancy among persons with schizophrenia or bipolar affective disorderThomas Munk Laursen
National Centre for Register Based Research, Aarhus University, Taasingegade 1, 8000 Aarhus C, Denmark
Schizophr Res 131:101-4. 2011..Mortality rates among individuals with schizophrenia or bipolar disorder are elevated compared to the general population...
- Projected life expectancy of people with HIV according to timing of diagnosisFumiyo Nakagawa
HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, University College London, UK
AIDS 26:335-43. 2012..Our aims were to estimate the life expectancy of an HIV-infected MSM living in a developed country with extensive access to ART and healthcare, and to ..
- Hazardous alcohol drinking and premature mortality in Russia: a population based case-control studyDavid A Leon
London School of Hygiene and Tropical Medicine, London, UK
Lancet 369:2001-9. 2007The reason for the low life expectancy in Russian men and large fluctuations in mortality are unknown. We investigated the contribution of alcohol, and hazardous drinking in particular, to male mortality in a typical Russian city.
- Fine-particulate air pollution and life expectancy in the United StatesC Arden Pope
Department of Economics, Brigham Young University, Provo, UT 84602 2363, USA
N Engl J Med 360:376-86. 2009..morbidity and mortality, suggesting that sustained reductions in pollution exposure should result in improved life expectancy. This study directly evaluated the changes in life expectancy associated with differential changes in fine ..
- Excess mortality, causes of death and life expectancy in 270,770 patients with recent onset of mental disorders in Denmark, Finland and SwedenMerete Nordentoft
Psychiatric Centre Copenhagen, University of Copenhagen, Faculty of Health Sciences, Copenhagen, Denmark
PLoS ONE 8:e55176. 2013..Excess mortality among patients with severe mental disorders has not previously been investigated in detail in large complete national populations...
- Outcomes of Nordic mental health systems: life expectancy of patients with mental disordersKristian Wahlbeck
Nordic School of Public Health, Nordic Research Academy in Mental Health, Gothenburg, Sweden, and National Institute for Health and Welfare THL, Vaasa, Finland
Br J Psychiatry 199:453-8. 2011People with mental disorders evince excess mortality due to natural and unnatural deaths. The relative life expectancy of people with mental disorders is a proxy measure of effectiveness of social policy and health service provision.
- Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in DrosophilaGerasimos P Sykiotis
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
Dev Cell 14:76-85. 2008..Interestingly, cancer chemopreventive drugs potently stimulate Drosophila Nrf2 activity, suggesting the fruit fly as an experimental system to identify and characterize such agents...
- Interferon therapy prolonged life expectancy among chronic hepatitis C patientsHaruhiko Yoshida
Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Bunkyo, Tokyo, Japan
Gastroenterology 123:483-91. 2002..The effects of interferon therapy in chronic hepatitis C patients on survival are unclear. Our objective was to analyze survival among a large cohort of chronic hepatitis C patients...
- Cause-specific life expectancies after 35 years of age for human immunodeficiency syndrome-infected and human immunodeficiency syndrome-negative individuals followed simultaneously in long-term cohort studies, 1984-2008Nikolas Wada
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Room E7648, Baltimore, MD 21205, USA
Am J Epidemiol 177:116-25. 2013..The results illuminate the changing face of mortality among the growing population infected with HIV...
- Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shorteningChen Yu Liao
Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Aging Cell 9:92-5. 2010..Although strains with shortened lifespan under 40% DR may not respond negatively under less stringent DR, the results raise the possibility that life extension by DR may not be universal...
- Forecasting the effects of obesity and smoking on U.S. life expectancySusan T Stewart
Harvard University Interfaculty Program for Health Systems Improvement, Boston, MA, USA
N Engl J Med 361:2252-60. 2009..Having a better understanding of the joint effects of these trends on longevity and quality of life will facilitate more efficient targeting of health care resources...
- Cost-effectiveness of screening for HIV in the era of highly active antiretroviral therapyGillian D Sanders
Duke Clinical Research Institute, Duke University, Durham, NC 27715, USA
N Engl J Med 352:570-85. 2005..The costs, benefits, and cost-effectiveness of screening for human immunodeficiency virus (HIV) in health care settings during the era of highly active antiretroviral therapy (HAART) have not been determined...
- Achieving health equity: from root causes to fair outcomesMichael Marmot
Lancet 370:1153-63. 2007..These cries are forming a global movement. The Commission on Social Determinants of Health places action to ensure fair health at the head and the heart of that movement...
- Inequalities in healthy life years in the 25 countries of the European Union in 2005: a cross-national meta-regression analysisCarol Jagger
Department of Health Sciences, University of Leicester, Leicester, UK
Lancet 372:2124-31. 2008Although life expectancy in the European Union (EU) is increasing, whether most of these extra years are spent in good health is unclear...
- Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life spanBradley J Willcox
Pacific Health Research Institute, 846 South Hotel Street, Suite 301, Honolulu, HI 96813, USA
Ann N Y Acad Sci 1114:434-55. 2007..The low caloric intake, long life expectancy, and the high prevalence of centenarians in Okinawa have been used as an argument to support the CR ..
- Obesity in adulthood and its consequences for life expectancy: a life-table analysisAnna Peeters
Department of Public Health, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Ann Intern Med 138:24-32. 2003Overweight and obesity in adulthood are linked to an increased risk for death and disease. Their potential effect on life expectancy and premature death has not yet been described.
- Alcohol and Russian mortality: a continuing crisisDavid A Leon
London School of Hygiene and Tropical Medicine, London, UK and Max Planck Institute for Demographic Research, Rostock, Germany
Addiction 104:1630-6. 2009Russia remains in the grip of a mortality crisis in which alcohol plays a central role. In 2007, male life expectancy at birth was 61 years, while for females it was 74 years...
- Age at menopause, cause-specific mortality and total life expectancyMarlies E Ossewaarde
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Epidemiology 16:556-62. 2005..The net effect on mortality is unclear. We determined the association of age at menopause with longevity and with the balance between cardiovascular and cancer mortality...
- Insulin-like signaling, nutrient homeostasis, and life spanAkiko Taguchi
Howard Hughes Medical Institute, Division of Endocrinology, Children s Hospital Boston, Harvard Medical School, Karp Family Research Laboratories, Boston, MA 02115, USA
Annu Rev Physiol 70:191-212. 2008..We discuss the possibility that the brain is the site where reduced insulin-like signaling can consistently extend mammalian life span-just as reduced insulin-like signaling extends the life span of lower metazoans...
- Life expectancy and cardiovascular mortality in persons with schizophreniaThomas M Laursen
National Centre for Register Based Research, Aarhus University, Aarhus C, Denmark
Curr Opin Psychiatry 25:83-8. 2012To assess the impact of cardiovascular disease on the excess mortality and shortened life expectancy in schizophrenic patients.
- JNK signaling confers tolerance to oxidative stress and extends lifespan in DrosophilaMeng C Wang
Department of Biomedical Genetics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 633, Rochester, NY 14642, USA
Dev Cell 5:811-6. 2003..Our work thus identifies the evolutionarily conserved JNK signaling pathway as a major genetic factor in the control of longevity...
- The clinical impact and cost-effectiveness of routine, voluntary HIV screening in South AfricaRochelle P Walensky
Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
J Acquir Immune Defic Syndr 56:26-35. 2011..Although 900,000 HIV-infected South Africans receive antiretroviral therapy, the majority of South Africans with HIV remain undiagnosed...
- Impact of smoking on mortality and life expectancy in Japanese smokers: a prospective cohort studyR Sakata
Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
BMJ 345:e7093. 2012To investigate the impact of smoking on overall mortality and life expectancy in a large Japanese population, including some who smoked throughout adult life.
- Rethinking the evolutionary theory of aging: transfers, not births, shape senescence in social speciesRonald D Lee
Department of Demography, University of California, 2232 Piedmont Avenue, Berkeley, CA 94720 2120, USA
Proc Natl Acad Sci U S A 100:9637-42. 2003..It also explains the evolution of lower fertility, longer life, and increased investments in offspring...
- Blood pressure in adulthood and life expectancy with cardiovascular disease in men and women: life course analysisOscar H Franco
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Hypertension 46:280-6. 2005Limited information exists about the consequences of hypertension during adulthood on residual life expectancy with cardiovascular disease...
- Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individualsArd I van Sighem
Stichting HIV monitoring, Academic Medical Centre of the University of Amsterdam, Amsterdam, The Netherlands
AIDS 24:1527-35. 2010..To compare life expectancies between recently diagnosed HIV-infected patients and age and sex-matched uninfected individuals from the general population...
- Contribution of major diseases to disparities in mortalityMitchell D Wong
Division of General Internal Medicine and Health Services Research, University of California at Los Angeles, Los Angeles 90095 1736, USA
N Engl J Med 347:1585-92. 2002..Mortality from all causes is higher for persons with fewer years of education and for blacks, but it is unknown which diseases contribute most to these disparities...
- Life expectancy of patients with newly-diagnosed HIV infection in the era of highly active antiretroviral therapyC T Fang
Department of Internal Medicine, National Taiwan University Hospital, No 7 Chung San South Road, Taipei, Taiwan
QJM 100:97-105. 2007Limited data are available on the life expectancy of patients with newly-diagnosed HIV infection in the era of highly active antiretroviral therapy (HAART).
- Effects of physical activity on life expectancy with cardiovascular diseaseOscar H Franco
Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
Arch Intern Med 165:2355-60. 2005..However, little is known about the effects of physical activity on life expectancy with and without cardiovascular disease...
- Widening socioeconomic inequalities in US life expectancy, 1980-2000Gopal K Singh
Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18 41, Rockville, MD 20857, USA
Int J Epidemiol 35:969-79. 2006This study examines changes in the extent of inequalities in life expectancy at birth and other ages in the United States between 1980 and 2000 by gender and socioeconomic deprivation levels.
- Welfare state regimes, infant mortality and life expectancy: integrating evidence from East AsiaYing Chih Chuang
School of Public Health, Taipei Medical University, Taipei, Taiwan
J Epidemiol Community Health 66:e23. 2012....
- The gap in life expectancy from preventable physical illness in psychiatric patients in Western Australia: retrospective analysis of population based registersDavid Lawrence
Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, PO Box 855 West Perth WA 6872 Australia
BMJ 346:f2539. 2013..To examine the mortality experience of psychiatric patients in Western Australia compared with the general population...
- Decomposition of socio-economic differences in life expectancy at birth by age and cause of death among 4 million South Korean public servants and their dependentsYoung Ho Khang
Department of Preventive Medicine, University of Ulsan College of Medicine, Seoul, Korea
Int J Epidemiol 39:1656-66. 2010Differences in life expectancy at birth across social classes can be more easily interpreted as a measure of absolute inequalities in survival...
- Gender differences in life expectancy and disability-free life expectancy among older adults in São Paulo, BrazilFlávia Cristina Drumond Andrade
University of Illinois at Urbana Champaign, Department of Kinesiology and Community Health, Champaign, Illinois 61820, USA
Womens Health Issues 21:64-70. 2011research on life expectancy has demonstrated the negative impact of disability on the health of older adults and its differential effects on women as evidenced by their higher disabled life expectancy (DLE)...
- Compression or expansion of morbidity? Trends in healthy-life expectancy in the elderly Austrian population between 1978 and 1998G Doblhammer
Max Planck Institute for Demographic Research, Rostock, Germany
Soc Sci Med 52:385-91. 2001..We use self-perceived health ratings to calculate healthy-life expectancy for the elderly population aged 60-89...
- Inequalities in premature mortality in Britain: observational study from 1921 to 2007Bethan Thomas
Social and Spatial Inequalities Group, Department of Geography, University of Sheffield, Sheffield S10 2TN
BMJ 341:c3639. 2010..To report on the extent of inequality in premature mortality as measured between geographical areas in Britain...
- Excess Indigenous mortality: are Indigenous Australians more severely disadvantaged than other Indigenous populations?Kenneth Hill
Center for Population and Development Studies, Harvard University, 9 Bow Street, Cambridge, MA 02138, USA
Int J Epidemiol 36:580-9. 2007..Studies indicate that the Indigenous population of Australia suffers a life expectancy disadvantage greater than differentials found in Indigenous populations of other developed countries...
- Prognostic factors and life expectancy in myelodysplastic syndromes classified according to WHO criteria: a basis for clinical decision makingLuca Malcovati
Division of Hematology, IRCCS, Policlinico San Matteo, 27100 Pavia, Italy
J Clin Oncol 23:7594-603. 2005..of the main prognostic factors in myelodysplastic syndromes (MDSs) classified into WHO subgroups, and to estimate mortality (standardized mortality ratio [SMR]) and life expectancy in these groups as a basis for clinical decision making.
- A model to estimate the lifetime health outcomes of patients with type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68)P M Clarke
Health Economics Research Centre, Department of Public Health, University of Oxford, Headington, Oxford, UK
Diabetologia 47:1747-59. 2004..a simulation model for type 2 diabetes that can be used to estimate the likely occurrence of major diabetes-related complications over a lifetime, in order to calculate health economic outcomes such as quality-adjusted life expectancy.
- Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancySimon A Babayan
Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom
PLoS Biol 8:e1000525. 2010..organisms, should optimize their development and reproduction in response to cues predicting future life expectancy. However, immune-dependent development by helminth parasites has so far eluded such evolutionary explanation...
- Cancer screening in elderly patients: a framework for individualized decision makingL C Walter
Division of Geriatrics, VA Medical Center 111G, 4150 Clement St, San Francisco, CA 94121, USA
JAMA 285:2750-6. 2001..Our framework first anchors decisions through quantitative estimates of life expectancy, risk of cancer death, and screening outcomes based on published data...
- Health, life expectancy, and mortality patterns among immigrant populations in the United StatesGopal K Singh
Surveillance Research Program, National Cancer Institute, Division of Cancer Control and Population Sciences, 6116 Executive Blvd, Suite 504, MSC 8316, Bethesda, MD 20892 8316, USA
Can J Public Health 95:I14-21. 2004..In this study, we examined the extent to which US- and foreign-born blacks, whites, Asians, and Hispanics differ in their health, life expectancy, and mortality patterns across the life course.
- The promise of prevention: the effects of four preventable risk factors on national life expectancy and life expectancy disparities by race and county in the United StatesGoodarz Danaei
Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS Med 7:e1000248. 2010..We estimated the effects of smoking, high blood pressure, elevated blood glucose, and adiposity on national life expectancy and on disparities in life expectancy and disease-specific mortality among eight subgroups of the US ..
- Mortality trends and setbacks: global convergence or divergence?Anthony J McMichael
National Centre for Epidemiology and Population Health, The Australian National University, Canberra, ACT, Australia 0200
Lancet 363:1155-9. 2004..In several regions, however, life expectancy has declined over the past 1-2 decades...
- Racial and sex disparities in life expectancy losses among HIV-infected persons in the united states: impact of risk behavior, late initiation, and early discontinuation of antiretroviral therapyElena Losina
Divisions of General Medicine, Department of Medicine, MA 02114, USA
Clin Infect Dis 49:1570-8. 2009....
- The naked mole-rat: a new long-living model for human aging researchRochelle Buffenstein
Department of Biology, City College of CUNY, Convent Ave at 138th St, New York, NY 10031, USA
J Gerontol A Biol Sci Med Sci 60:1369-77. 2005..Young naked mole-rats surprisingly have high levels of accrued oxidative damage. With their similar longevity quotient to humans, these rodents may provide a novel opportunity to examine mechanisms modulating aging...
- Social capital, life expectancy and mortality: a cross-national examinationBrendan Kennelly
Department of Economics, The National University of Ireland, Galway, Ireland
Soc Sci Med 56:2367-77. 2003..The paper casts doubt upon the widely accepted hypothesis that social capital has a positive effect on health and illustrates the importance of testing this kind of hypothesis in an extended model...
- The changing relation between education and life expectancy in central and eastern Europe in the 1990sVladimir M Shkolnikov
Max Planck Institute for Demographic Research, Rostock, Germany
J Epidemiol Community Health 60:875-81. 2006..in central and eastern Europe has been generally associated with widening educational differences in life expectancy. However, interpretation of these findings is complicated because the size of educational categories within ..
- The evolving pattern of avoidable mortality in RussiaEvgueni M Andreev
Laboratory of Analysis and Prognosis of Population Mortality, Centre of Demography and Human Ecology, Institute of Economic Forecasting, Russian Academy of Sciences, 47 Nakhimovsky Prospect, 117418 Moscow, Russian Federation
Int J Epidemiol 32:437-46. 2003b>Life expectancy at birth in Russia is over 12 years less than in western Europe...
- Decomposition of differences in health expectancy by causeWilma J Nusselder
Department of Public Health, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Demography 41:315-34. 2004..This method is an extension of the decomposition method for life expectancy developed by Arriaga...
- Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infectionSue J Goldie
Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115 5924, USA
Am J Med 115:632-41. 2003..To explore the cost-effectiveness of interventions to improve adherence to combination antiretroviral therapy in patients with human immunodeficiency virus (HIV) infection...
- Disability life expectancy for the elderly, city of Sao Paulo, Brazil, 2000: gender and educational differencesMirela Castro Santos Camargos
Departamento de Demografia, CEDEPLAR, UFMG, Minas Gerais, Brazil
J Biosoc Sci 39:455-63. 2007There is evidence that 'health life expectancy' (expected number of years to be lived in health) differs by socioeconomic status. Time spent in health or disability plays a critical role in the use of health care services...
- Impact of HAART and injection drug use on life expectancy of two HIV-positive cohorts in British ColumbiaElisa Lloyd-Smith
Department of Health Care and Epidemiology, University of British Columbia, Vancouver, British Columbia, Canada
AIDS 20:445-50. 2006..However, there is evidence that not all populations have benefited equally from HAART and that mortality rates are higher in HIV-infected injection drug users than in non-users...
- Cost-effectiveness of HIV treatment in resource-poor settings--the case of Côte d'IvoireSue J Goldie
Department of Health Policy and Management, Program in Health Decision Science, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 355:1141-53. 2006..As antiretroviral therapy is increasingly used in settings with limited resources, key questions about the timing of treatment and use of diagnostic tests to guide clinical decisions must be addressed...
- Life expectancy living with HIV: recent estimates and future implicationsFumiyo Nakagawa
Research Department of Infection and Population Health, UCL, London, UK
Curr Opin Infect Dis 26:17-25. 2013The life expectancy of people living with HIV has dramatically increased since effective antiretroviral therapy has been available, and still continues to improve...
- Successful deinstitutionalization of mental health care: increased life expectancy among people with mental disorders in FinlandJeanette Westman
Nordic School of Public Health, Gothenburg, Sweden
Eur J Public Health 22:604-6. 2012To assess impact of deinstitutionalization of mental health care, we studied life expectancy for 341 630 people with hospitalization or early retirement pension for mental disorders in 1981-2003 in Finland...
- The impact of functional status on life expectancy in older personsEmmett Keeler
Multicampus Program in Geriatric Medicine and Gerontology, Division of Geriatrics, Department of Medicine, David Geffen School of Medicine at UCLA, 10945 Le Conte Avenue, Suite 2339, Los Angeles, CA 90095 1687
J Gerontol A Biol Sci Med Sci 65:727-33. 2010..Inclusion of functional status may permit more precise prognostic estimates of life expectancy and proportion of time in various functional states.
- Understanding the rapid increase in life expectancy in South KoreaSeungmi Yang
Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada
Am J Public Health 100:896-903. 2010We assessed life expectancy increases in the past several decades in South Korea by age and specific causes of death.
- The relationship between health and GDP in OECD countries in the very long runRobyn Swift
Griffith Business School, Griffith University, Brisbane, Queensland, Australia
Health Econ 20:306-22. 2011..A similar, long run, cointegrating relationship between life expectancy and both total GDP and GDP per capita was found for all the countries estimated...
- Quality-adjusted life expectancy (QALE) and loss of QALE for patients with ischemic stroke and intracerebral hemorrhage: a 13-year follow-upHsin Yi Lee
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan
Stroke 41:739-44. 2010..The aim of this study is to quantify the loss of quality-adjusted life expectancy related to ischemic stroke and intracerebral hemorrhage.
- Dementia and life expectancy: what do we know?Michelle Lee
David Geffen School of Medicine, UCLA, Division of Geriatric Medicine, Los Angeles, CA 90095, USA
J Am Med Dir Assoc 10:466-71. 2009..Dementia is a common geriatric syndrome. It is unclear how best to predict survival among dementia patients, which leaves clinicians, patients, and families uncertain as to how to proceed with medical decisions and reassessing goals...
- The physical activity transitionPeter T Katzmarzyk
Pennington Biomedical Research Center, Perkins Rd, Baton Rouge, LA 70808, USA
J Phys Act Health 6:269-80. 2009..and to explore the potential effects that declining physical activity levels may play on health and life expectancy as countries undergo economic and demographic changes...
- The influence of subjective life expectancy on health state valuations using a 10 year TTOF E van Nooten
Department of Health Policy and Management, Erasmus University Rotterdam Erasmus MC, Rotterdam, The Netherlands
Health Econ 18:549-58. 2009To investigate if subjective life expectancy (SLE) impacts the willingness to trade-off (WTT) and the number of years traded-off in a 10-years time trade-off (TTO) exercise to obtain health state valuations.
- The aging process and potential interventions to extend life expectancyMatteo Tosato
Department of Gerontology, Geriatrics and Physiatry, Catholic University of Sacred Heart, Rome, Italy
Clin Interv Aging 2:401-12. 2007..Nevertheless, several studies on animal models have shown that aging rates and life expectancy can be modified...
- Higher education delays and shortens cognitive impairment: a multistate life table analysis of the US Health and Retirement StudyMieke Reuser
Netherlands Interdisciplinary Demographic Institute NIDI, The Hague, The Netherlands
Eur J Epidemiol 26:395-403. 2011..The effect of education is more pronounced among ethnic minorities. Higher life expectancy goes together with a longer period of cognitive impairment, but not for higher levels of education: that ..
- The aftershock of deindustrialization--trends in mortality in Scotland and other parts of post-industrial EuropeDavid Walsh
Glasgow Centre for Population Health, Glasgow, Scotland, UK
Eur J Public Health 20:58-64. 2010..This begs the question: to what extent is poor health a common outcome in other post-industrial regions and how does Scotland's experience compare to these other comparable regions?..
- What has made the population of Japan healthy?Nayu Ikeda
Department of Global Health Policy, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Lancet 378:1094-105. 2011People in Japan have the longest life expectancy at birth in the world. Here, we compile the best available evidence about population health in Japan to investigate what has made the Japanese people healthy in the past 50 years...
- Life expectancies and incidence rates of patients under prolonged mechanical ventilation: a population-based study during 1998 to 2007 in TaiwanMei Chuan Hung
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, No 17, Xuzhou Road, Taipei 100, Taiwan
Crit Care 15:R107. 2011..The present study examined the median survival, life expectancies, and cumulative incidence rate (CIR) of patients undergoing prolonged mechanical ventilation (PMV) stratified by different underlying diseases...
- Contribution of obesity to international differences in life expectancySamuel H Preston
University of Pennsylvania, Philadelphia, PA 19104, USA
Am J Public Health 101:2137-43. 2011..The United States has the highest prevalence of obesity and one of the lowest life expectancies among high-income countries. We investigated the relationship between these 2 phenomena...
- The free radical theory of agingDenham Harman
University of Nebraska College of Medicine, Department of Medicine, Omaha, NE 68198 4635, USA
Antioxid Redox Signal 5:557-61. 2003..Aging changes may be caused by free radical reactions. The extensive studies based on this possibility hold promise that the ALE-B can be extended to >85 years and the maximum life span increased...
- Managing cystic fibrosis: strategies that increase life expectancy and improve quality of lifeMalena Cohen-Cymberknoh
Department of Pediatrics and CF Center, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Am J Respir Crit Care Med 183:1463-71. 2011..The purpose of this review is to survey recent developments in CF care that are responsible for the improved survival and quality of life of patients with CF...
- Brain stem metastases treated with radiosurgery: prognostic factors of survival and life expectancy estimationJosé G Lorenzoni
Department of Neurosurgery, Hopital Erasme, Gamma Knife Center, Universite Libre de Bruxelles, 1000 Brussels, Belgium
Surg Neurol 71:188-95; discussion 195, 195-6. 2009The objective of this study is to study prognostic factors of survival and 3 stratification systems for life expectancy estimation in patients with brain stem metastases treated with radiosurgery.
- Vitamin E may affect the life expectancy of men, depending on dietary vitamin C intake and smokingHarri Hemilä
Department of Public Health, University of Helsinki, Helsinki, Finland
Age Ageing 40:215-20. 2011..antioxidants might protect against oxidative stress, which has been suggested as a cause of aging...
- Geographical variation in life expectancy at birth in England and Wales is largely explained by deprivationLaura M Woods
Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
J Epidemiol Community Health 59:115-20. 2005To describe the population mortality profile of England and Wales by deprivation and in each government office region (GOR) during 1998, and to quantify the influence of geography and deprivation in determining life expectancy.
- The cost effectiveness of combination antiretroviral therapy for HIV diseaseK A Freedberg
Division of General Internal Medicine and the Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
N Engl J Med 344:824-31. 2001..We estimated the clinical benefits and cost effectiveness of three-drug antiretroviral regimens...
- Adult obesity and the burden of disability throughout lifeAnna Peeters
Department of Public Health, Erasmus MC, Rotterdam, The Netherlands
Obes Res 12:1145-51. 2004To analyze the prevalence of disability throughout life and life expectancy free of disability, associated with obesity at ages 30 to 49 years.
- Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapyViviane D Lima
BC Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, British Columbia, Canada
AIDS 21:685-92. 2007To characterize the temporal changes in mortality and life expectancy among HIV-positive individuals initiating antiretroviral therapy in British Columbia, Canada, from 1993 to 2004.
- Premature mortality from general medical illnesses among persons with bipolar disorder: a reviewBabak Roshanaei-Moghaddam
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, USA
Psychiatr Serv 60:147-56. 2009..The authors reviewed the literature to determine whether there is evidence of increased risk of mortality from general medical causes among patients with bipolar spectrum disorders...
- Association between benign and malignant peripheral nerve sheath tumors in NF1T Tucker
Department of Medical Genetics, University of British Columbia, Vancouver, Canada
Neurology 65:205-11. 2005..The authors conducted a study to determine whether people with NF1 who have benign neurofibromas of various kinds are at greater risk of developing MPNSTs than patients with NF1 who lack these benign tumors...
- Life expectancy after HIV diagnosis based on national HIV surveillance data from 25 states, United StatesKathleen McDavid Harrison
Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Acquir Immune Defic Syndr 53:124-30. 2010We estimate life expectancy and average years of life lost (AYLL) after an HIV diagnosis using population-based surveillance data from 25 states that have had name-based HIV surveillance since 1996.
- The Global Activity Limitation Index measured function and disability similarly across European countriesCarol Jagger
Department of Health Sciences, University of Leicester, Leicester, United Kingdom
J Clin Epidemiol 63:892-9. 2010..This work aims to validate and increase understanding of the Global Activity Limitation Index (GALI), an activity limitation measure from which the new structural indicator Healthy Life Years is generated...
- Smoking kills, obesity disables: a multistate approach of the US Health and Retirement SurveyMieke Reuser
Netherlands Interdisciplinary Demographic Institute, The Hague, The Netherlands
Obesity (Silver Spring) 17:783-9. 2009..9), nonsmoking and high education. Mild obesity (BMI: 30-34.9) did not change total life expectancy (LE) but exchanged disabled for disability-free years. Mild obesity decreased disability-free LE with 2...
- Survival in Duchenne muscular dystrophy: improvements in life expectancy since 1967 and the impact of home nocturnal ventilationMichelle Eagle
Newcastle Muscle Centre, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
Neuromuscul Disord 12:926-9. 2002..4 years, whereas for those ventilated since 1990 it was 25.3 years. Cardiomyopathy significantly shortened life expectancy from 19 years to a mean age of 16.9 years...
- Infant mortality rate as an indicator of population healthD D Reidpath
School of Health Sciences, Deakin University, Burwood, Australia
J Epidemiol Community Health 57:344-6. 2003..More comprehensive measures such as disability adjusted life expectancy (DALE) have come into favour as alternatives...
- Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1Kevin J Bitterman
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:45099-107. 2002..We discuss the possibility that nicotinamide is a physiologically relevant regulator of Sir2 enzymes...
- Mortality in neurofibromatosis 1: an analysis using U.S. death certificatesS A Rasmussen
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Am J Hum Genet 68:1110-8. 2001..46-3.32 at 20-29 years) but not in older persons. This study supports previous findings of decreased life expectancy for persons with NF1 and, within the limitations of death certificates, provides population-based data about ..
- Years of life lost due to obesityKevin R Fontaine
Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
JAMA 289:187-93. 2003..Public health officials and organizations have disseminated health messages regarding the dangers of obesity, but these have not produced the desired effect...
- Puzzles, promises and a cure for ageingJan Vijg
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA
Nature 454:1065-71. 2008..A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect...
- What is successful ageing and who should define it?Ann Bowling
Department of Primary Care and Population Sciences, University College London, London NW3 2PF
BMJ 331:1548-51. 2005
- Schizophrenia and increased risks of cardiovascular diseaseCharles H Hennekens
Department of Biomedical Science, Center of Excellence in Biomedical and Marine Biotechnology, Florida Atlantic University, FL, USA
Am Heart J 150:1115-21. 2005..The aim of the study is to review the absolute and relative impacts of the major causes for premature mortality among patients with schizophrenia...
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2013DESCRIPTION (provided by applicant): Owing to the increase in obesity, life expectancy may start to decrease in developed countries for the first time...
- Role of JAK2-PAK1 interaction in prolactin-dependent signalingMaria Diakonova; Fiscal Year: 2013..Based on the current life expectancy for women in the United States, 1 out of 9 women will develop breast cancer in her lifetime - a risk that was ..
- Pathobiology of Cystic Fibrosis-Related Diabetes in a Ferret ModelZoe Stewart; Fiscal Year: 2013..patients, pancreatic disease leads to diabetes mellitus in up to 50% of adult patients, resulting in reduced life expectancy. Progress in elucidating the pathophysiology of CFRD has been hindered by the lack of an animal model. Dr...
- Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer'sPadmakar Kulkarni; Fiscal Year: 2010..With increasing life expectancy and aging baby-boomer generation, the estimated future costs of treatment and elderly patient care, and its ..
- Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?Qinghua Sun; Fiscal Year: 2010Owing to the increase in obesity, life expectancy may start to decrease in developed countries for the first time. Environmental factors are increasingly found to be associated with the development of obesity...
- Role of TPH2 and 5HT Neuronal Loss in Non-motor Symptoms of Parkinson'sDonald M Kuhn; Fiscal Year: 2012..L-DOPA-induced, are not trivial and contribute to worsened disability, impaired quality of life and shortened life expectancy. Therefore, a better understanding of the mechanisms responsible for the non-motor symptoms that accompany ..
- The Role of Alcohol in HIV Therapy HepatotoxicityCraig J McClain; Fiscal Year: 2012..Since the introduction of highly active antiretroviral therapy (HAART) in 1996, the life expectancy of patients with HIV has increased significantly...
- A dataset for the study of the social determinants of health.Peter A Muennig; Fiscal Year: 2010..me fairly," as having a racial component), and, finally, a means for translating mortality differences into life expectancy differences so that the policy implications of researchers'findings can be more easily understood...
- Regulation of Metabolism by Dietary SterolsSHAILENDRA BHANUBHAI PATEL; Fiscal Year: 2013..We show that Abcg8 knockout mice, exposed to a plant sterol diet, have significantly reduced life expectancy, are infertile and manifest reduced adipose tissue stores...
- Developmental Origins of Phenotypic Characteristics that Predict LongevityAndrzej Bartke; Fiscal Year: 2012..And what early lifestyle and/or pharmacological interventions could effectively increase healthspan and life expectancy? PUBLIC HEALTH RELEVANCE: There is considerable evidence that growth hormone (GH) and other hormones that ..
- Analysis of FIP200 in signal transductionJun Lin Guan; Fiscal Year: 2012..RELEVANCE: Neurodegenerative diseases are major and increasing health threats as a result of the increased life expectancy and aging population in the United States...
- Autophagy and human islet amyloid polypeptide in animal models of type 2 diabetesJacqueline Rivera; Fiscal Year: 2013..In people with type 2 diabetes there is a shortened life expectancy through vascular complications as well as an increased risk of several cancers...
- Cardiometabolic Risk Factors and Obesity in Adolescents with Down SyndromeSheela Natesh Magge; Fiscal Year: 2013..With a life expectancy of 60 years, individuals with Down syndrome are in need of health care that is preventative, evidence-based, ..
- CANCER AND CHANGING TRENDS IN US MORTALITY INEQUITIES: 1960-2004Nancy Krieger; Fiscal Year: 2010..research on trends in socioeconomic health inequities has focused on such outcomes as all-cause mortality, life expectancy, or infant mortality, with analyses typically extending back only to the 1980s...
- Development of Inhaled Vancomycin for Treatment of MRSA Infections in CFTaneli Jouhikainen; Fiscal Year: 2012..infections, which are prevalent in 40-50% of CF patients, and have been shown to be associated with a shorter life expectancy compared to CF patients without MRSA...
- AREA: Rapamycin, ambient temperature, and longevitySteven J Swoap; Fiscal Year: 2010....
- The altered lipid and protein metabolism of pediatric patients with HIV infectionFarook Jahoor; Fiscal Year: 2010..therapy (HAART) has markedly reduced the morbidity and mortality of HIV- infected children, the improved life expectancy is associated with a complex set of metabolic disorders in a subset of patients...
- Control of HIV drug resistance in older patientsAlonso Heredia; Fiscal Year: 2010Highly active antiretroviral therapy (HAART) has dramatically increased life expectancy in HIV infection and by 2015 more than half of HIV patients in the U.S. will be older than 50...
- Regulated Transgene Expression in the RetinaJames M Wilson; Fiscal Year: 2010..disease is a major cause for visual disability among persons over 60 years of age that with the increase in life expectancy is not only a medical problem but also one with a significant socio-economic impact...
- Rapid Heart Attack Detection using an AC Electrokinetic DeviceRajaram Krishnan; Fiscal Year: 2011..Moreover, this trend is expected to dramatically worsen given global life expectancy increases, population growth, and the rapidly escalating prevalence of obesity and diabetes...
- Biology of Aerobic Capacity and Insulin ResistanceCharles F Burant; Fiscal Year: 2012..Indeed, oxidative capacity is an excellent predictor of life expectancy. Decreases in skeletal muscle mitochondrial oxidative phosphorylation can be found in individuals who are ..
- Mechanisms of mitochondrial fission/fusion dysregulation during HIV-1-associatedJEREL ADAM FIELDS; Fiscal Year: 2013..Moreover, HAART increases life expectancy and an increasingly large pool of HIV patients are managing viral infection confounded by processes of aging...
- Humanization of hFcRn Mice for Physiological Evaluation of Therapeutic AntibodiesMICHAEL VAN WILES; Fiscal Year: 2013..We fully expect these models to more accurately reflect human IgG and human albumin biology and, therefore, rapidly advance drug development and FcRn biology. ..
- Identification of Mammalian Genes Promoting Life ExtensionSIU HUNG CHICK; Fiscal Year: 2013..We anticipate that the insights gained from these studies will foster a variety of new directions for aging research. ..
- Measles Virotherapy and radiovirotherapy in the Treatment of recurrent gliomasEvanthia Galanis; Fiscal Year: 2013..gliomas are responsible for a disproportionate amount of morbidity, in addition to significant reduction in life expectancy. In preclinical models, measles vaccine strains have potent antitumor activity against gliomas and ..
- Exploring the Role of the Brain Epigenome: Cognitive Decline and Life ExperiencesDavid Alan Bennett; Fiscal Year: 2013DESCRIPTION (provided by applicant): As a result of declining fertility and increasing life expectancy, the 21st century will continue to witness the remarkable increase in the number and proportion of older persons that began in the ..
- Drak2-A Potential Therapeutic Target for Type 1 DiabetesBlaine Creasy; Fiscal Year: 2010..S. Improved therapies to treat diabetes would greatly enhance the quality and life expectancy for the millions who suffer from this devastating disease...
- Sleep and Cardiovascular HealthPhyllis C Zee; Fiscal Year: 2012DESCRIPTION (provided by investigator): With increase in life expectancy, there has also been a parallel increase in chronic co- morbidities that impair functional status and quality of life in older age...
- Multi-Dimensional Successful Aging Among HIV-Infected AdultsDavid J Moore; Fiscal Year: 2013DESCRIPTION (provided by applicant): The life expectancy of adults receiving antiretroviral therapy (ART) has been increasing progressively. By 2015 one-half of HIV+ people in the U.S...
- Omega-3 Fatty Acid Administration In Dialysis PatientsTalat Alp Ikizler; Fiscal Year: 2010..There are currently more than 300,000 patients receiving chronic dialysis therapy in the United States and the life expectancy for these patients are only 1/3 to 1/6 of those for the general population...
- IL-15 Superagonist Complex as an Immunotherapeutic for Multiple MyelomaHing C Wong; Fiscal Year: 2012..The number of geriatric MM patients is expected to increase over time because of the increasing life expectancy of the normal population...
- Comparative Effectiveness of Post-Discharge Strategies for Hospitalized SmokersNancy A Rigotti; Fiscal Year: 2013..S. Smoking cessation reduces risk and extends life expectancy. This project aims to identify a cost-effective strategy for delivering smoking cessation treatment to the ..
- LIPOLYSIS AND OLEOYLETHANOLAMIDE SIGNALING IN THE REGULATION OF LONGEVITYANDREW K FOLICK; Fiscal Year: 2013....
- Pediatric Nephrology Seminar XXXIXGASTON E ZILLERUELO; Fiscal Year: 2012..This is consistent with the Healthy People 2010 goal of helping individuals of all ages increase life expectancy and improve their quality of life, specifically in the areas of maternal, infant and child health.
- Comparative Effectiveness of Dialysis ModalitiesRajnish Mehrotra; Fiscal Year: 2013....
- MHC class II-Associated Endothelial DysfunctionJoseph Holoshitz; Fiscal Year: 2010..The results of this study could shed much needed light on a disease that shortens life expectancy of rheumatoid arthritis patients and could identify novel targets for future therapy.
- Immune determinants of adaptive thermogenesisAjay Chawla; Fiscal Year: 2013..In addition to its impact on disease and life expectancy, the medical care costs of obesity in the United States are staggering, exceeding $147 billion in 2008...
- Studying a bone marrow failure disease using patient-specific iPS cellsLUIS ZIRNBERGER BATISTA; Fiscal Year: 2013..patients suffering with dyskeratosis congenita (DC), a bone-marrow failure syndrome that presents with poor life expectancy and multi-systemic tissue defects that include aplastic anemia and pulmonary fibrosis...
- Pediatric Cancer, Family Conflict and Child AdjustmentLynn Fainsilber Katz; Fiscal Year: 2013DESCRIPTION (provided by applicant): With the improved life expectancy of most children with cancer, attention has been turned to improving the quality of life of cancer survivors and their family members...
- Anti-biofilm agents for treating pulmonary infection in Cystic Fibrosis patientsLAURA MICHELLE GUOGAS; Fiscal Year: 2011..An improved treatment for CF has the potential to both extend the life expectancy and improve the quality of life for the hundreds of thousands of individuals worldwide who are living with CF. ..
- The Down Syndrome Growing Up StudyBabette S Zemel; Fiscal Year: 2012..S. children with DS are available but outdated. Advances in health care and improved life expectancy of children with DS have occurred in the past few decades, and there is a well- recognized need for revised ..
- METABOLISM OF THE VLDL RECEPTOR AND APOE RECEPTOR 2JOACHIM J HERZ; Fiscal Year: 2013....
- Neuroprotective Gene Therapy in the Brain of Senile RatsRodolfo G Goya; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: The increase in life expectancy achieved by modern medicine has led to a progressive rise in the incidence of age-related neurodegenerative ..
- Improving the Kinetics and Reliability of Continuous Glucose MonitoringBrett D Mensh; Fiscal Year: 2012..with type 1 diabetes mellitus (T1DM) will experience dramatic improvements in their quality of life and life expectancy when the goal of engineering an artificial pancreas is finally realized...
- CFFONE: A Cell Phone Support Program for Adolescents with Cystic FibrosisKEVIN F DAWKINS; Fiscal Year: 2010..With cutting-edge research spurring medical advances, each decade has shown improved survival, from a median life expectancy of 5 years in 1960, to 16 years in 1970, to 35 years today...
- Muscularization of pulmonary arteries induced by an adaptive immune responseGabriele Grunig; Fiscal Year: 2010..hypertension (PAH) is a devastating condition because of its deleterious impact on quality of life, and life expectancy. Clinical correlation studies have suggested an immune pathogenesis because of the increased incidence of PAH ..
- Rewarding experience and the aging brainErica R Glasper; Fiscal Year: 2010..PUBLIC HEALTH RELEVANCE: the mean life expectancy is extended due to advances in modern science and medicine, many concerns regarding the physical and mental ..
- Akt/CREB signaling: Target for prostate cancerAddanki P Kumar; Fiscal Year: 2013..In addition with increasing life expectancy of the Veteran population, prostate cancer will continue to be a major health problem...
- Therapeutic correction of deltaF508-CFTR cystic fibrosis by a novel PDZ12 drug.Alvin Bach; Fiscal Year: 2013..CF patients have a life expectancy of 37 years and need intensive therapeutic interventions for chronic co-morbidities and symptoms...
- CVD in American Indians: Imaging and Cardiovascular CenterRichard B Devereux; Fiscal Year: 2013..Secular trends, life expectancy, the effects of renal disease on preclinical CVD, and the role of preclinical measures in predicting CVD ..
- CVD in American Indians Study and Data Management Center and OK Field CenterELISA TAN LEE; Fiscal Year: 2013..Secular trends, life expectancy, the effects of renal disease on preclinical CVD, and the role of preclinical measures in predicting CVD ..
- Gene Transfer for Recessive Dystrophic Epidermolysis BullosaMATT PETER MARINKOVICH; Fiscal Year: 2013..RDEB subjects have a shortened life expectancy with early death from infection, organ failure or squamous cell carcinoma (SCC)...
- Environmental Attributes and Weight Control: Study of Over 1.3 Million VeteransShannon N Zenk; Fiscal Year: 2013..S. medical spending, and conservatively accounts for 30% of the gap in life expectancy between Americans and their counterparts in 13 other high-income countries...
- Health Promotion and Fitness for Younger and Older Adults With SMIStephen J Bartels; Fiscal Year: 2012DESCRIPTION (provided by applicant): Adults with serious mental illness (SMI) have a 20 percent reduced life expectancy and disproportionately greater prevalence of medical comorbidity associated with high rates of obesity, sedentary ..
- A Caribbean Project for Clinical and Basic Neuroscience ResearchEDMUNDO NELSON KRAISELBURD; Fiscal Year: 2011..Neurological complications of HIV are becoming more evident with advances in the treatment and extended life expectancy of HIV-infected patients...
- Systems Biology for Studies of Cognition in Down SyndromeKatheleen Gardiner; Fiscal Year: 2012The incidence of Down syndrome (DS) is one in 700 live births, the life expectancy is now >50 years, and the average IQ is approximately 50. Therefore, DS is a significant social and medical issue...
- Human Gene Knockdowns that May Extend LifespanCynthia J Kenyon; Fiscal Year: 2013..This fresh approach will define new potential drug targets for extending the youthful and productive years of human life, and for delaying age-related diseases such as cancer, heart disease and/or neurodegenerative disease. ..
- Metabolic Screening: Prioritizing Implementation Strategies for Mental HealthElaine H Morrato; Fiscal Year: 2013..with serious mental illness, excess cardiovascular risk contributes to decades of reduced life expectancy. Physicians prescribing second-generation antipsychotics (SGA) will be studied to focus the analysis because ..
- Randomized Trial of Achieving Healthy Lifestyles in Psych RehabilitationGail L Daumit; Fiscal Year: 2012..conditions likely contribute substantially to premature cardiovascular disease and the 20 percent shortened life expectancy in SMI...
- ADOLESCENT MEDICINE HIV/AIDS RESEARCH NETWORKAnna Barbara Moscicki; Fiscal Year: 2001..With the increased life expectancy of HIV infected persons, the rates of anogenital cancers can be expected to continue to rise...
- Novel Molecular and Cellular Therapies in Fanconi AnemiaDavid Williams; Fiscal Year: 2009..This grant proposal seeks funding to conduct these clinical trials and further develop retrovirus-mediated complementation analysis in a CAP/CLIA environment for use in clinical management of FA patients. ..
- Open-Source Informatics Used to Improve Outcomes in Pediatric Liver TransplantsSTEVEN PETER BUCUVALAS; Fiscal Year: 2010..the same two-year old can receive a liver transplant and, with ongoing treatment, a potentially normal life expectancy. Some 500 children undergo pediatric liver transplantation (PLT) annually in the U.S...
- The Treatment of Methotrexate Resistant Rheumatoid Arthritis With AminopterinStuart Kahn; Fiscal Year: 2009..of the population, and is associated with progressive joint destruction, functional disability and decreased life expectancy. Methotrexate (MTX), an antifolate used alone or in combination with other medicines, is the current mainstay ..
- Viscoelastic deformation of bone matrix in postmenopauseDo Gyoon Kim; Fiscal Year: 2010..These types of fractures will likely become more common as human life expectancy increases...
- The UAB Spina Bifida Patient Registry Demonstration ProjectDavid B Joseph; Fiscal Year: 2010..to new medical treatments and technology, most people born with Spina Bifida can expect to live a normal life expectancy. Those with this challenging birth defect are living longer, more productive lives than was dreamed of just ..
- Development of a National Incompatible Kidney Transplant RegistryRobert A Montgomery; Fiscal Year: 2010..Live donor kidney transplantation is the best treatment for kidney failure, doubling life expectancy and significantly improving quality of life...
- Pharmacogenetics of Methotrexate Therapy in ArthritisALEXANDER WHITEHEAD; Fiscal Year: 2006..provided by applicant): Inflammatory diseases, including arthritis, are often associated with reduced life expectancy, due in part to an excess of cardiovascular disease deaths...
- Effectiveness of Early Stage Prostate Cancer TreatmentMARTIN G contact SANDA; Fiscal Year: 2010..of prostate cancer treatment has been previously evaluated by Markov models to measure Quality-adjusted Life Expectancy (QALE), but these comparisons did not use prospectively collected HRQOL outcome data to assign transition ..
- Guideline Adherence and Health Outcomes in Medicare FFS Patients with DiabetesMaureen Smith; Fiscal Year: 2009..increased risks have even more significance if the benefits of tight control are limited due to shortened life expectancy. If the long-term benefits are not relevant and the short-term risks are significant, there may be little ..
- NHLBI MINORITY INSTITUTION RESEARCH SCIENTIST DEVELOPMENMARIA DEL PILAR AGUINAGA; Fiscal Year: 2004..anemia with recurrent vasoocclusive episodes, secondary complications, impaired quality of life and a reduced life expectancy. Sickle cell disease is caused by the substitution of glutamic acid with valine at the position of amino acid ..
- CFFONE: A Cell Phone Support Program for Teens with Cystic FibrosisKevin Dawkins; Fiscal Year: 2007..With cutting-edge research spurring medical advances, each decade has shown improved survival, from a median life expectancy of 5 years in 1960, to 16 years in 1970, to 35 years today...
- CLONING OF FAMILIAL PRIMARY PULMONARY HYPERTENSION GENEWilliam Nichols; Fiscal Year: 2006..Definitive diagnosis requires cardiac catheterization. Average life expectancy after diagnosis is now more than 2 to 3 years with the development of new treatments in recent years...
- Quantifying altered hemodynamics in response to stenting for aortic coarctationJOHN LADISA; Fiscal Year: 2009..Although excellent treatments for CoA exist, life expectancy is substantially reduced and long-term problems including hypertension often develop...
- COST-EFFECTIVE MANAGEMENT OF HIV-RELATED ILLNESSESAnna Tosteson; Fiscal Year: 1991..Our CNS model will assess the life-expectancy, quality-adjusted life expectancy, short term morbidity, cost, and cost-effectiveness of all clinically reasonable management strategies in ..