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Summary

Summary: An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.

Top Publications

  1. ncbi Sepsis in European intensive care units: results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:344-53. 2006
  2. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
  3. ncbi ESPEN Guidelines on Enteral Nutrition: Intensive care
    K G Kreymann
    Department of Intensive Care Medicine, University Hospital Eppendorf, Hamburg, Germany
    Clin Nutr 25:210-23. 2006
  4. pmc Brazilian Sepsis Epidemiological Study (BASES study)
    Eliezer Silva
    Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Crit Care 8:R251-60. 2004
  5. ncbi Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia
    Manuel Iregui
    Pulmonary and Critical Care Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 122:262-8. 2002
  6. ncbi Pro- and synbiotics to control inflammation and infection in patients with multiple injuries
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece
    J Trauma 67:815-21. 2009
  7. ncbi Prolonged intensive care unit stay in cardiac surgery: risk factors and long-term-survival
    Ortrud Vargas Hein
    Department of Anesthesiology and Intensive Care Medicine, Campus Charite Mitte, Charite University Medicine Berlin, Berlin, Germany
    Ann Thorac Surg 81:880-5. 2006
  8. ncbi Lipopolysaccharide binding protein in a surgical intensive care unit: a marker of sepsis?
    Yasser Sakr
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
    Crit Care Med 36:2014-22. 2008
  9. ncbi Prediction about severity and outcome of sepsis by pro-atrial natriuretic peptide and pro-adrenomedullin
    Rui lan Wang
    First People s Hospital, Shanghai Jiaotong University, China
    Chin J Traumatol 13:152-7. 2010
  10. ncbi Routine use of the confusion assessment method for the intensive care unit: a multicenter study
    Maarten M van Eijk
    Department of Intensive Care Medicine, University Medical Center Utrecht, The Netherlands
    Am J Respir Crit Care Med 184:340-4. 2011

Detail Information

Publications354 found, 100 shown here

  1. ncbi Sepsis in European intensive care units: results of the SOAP study
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Crit Care Med 34:344-53. 2006
    ..To better define the incidence of sepsis and the characteristics of critically ill patients in European intensive care units...
  2. ncbi Early goal-directed therapy in the treatment of severe sepsis and septic shock
    E Rivers
    Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
    N Engl J Med 345:1368-77. 2001
    ..The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit...
  3. ncbi ESPEN Guidelines on Enteral Nutrition: Intensive care
    K G Kreymann
    Department of Intensive Care Medicine, University Hospital Eppendorf, Hamburg, Germany
    Clin Nutr 25:210-23. 2006
    ..There is no general indication for immune-modulating formulae in patients with severe illness or sepsis and an APACHE II Score >15. Glutamine should be supplemented in patients suffering from burns or trauma.
  4. pmc Brazilian Sepsis Epidemiological Study (BASES study)
    Eliezer Silva
    Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
    Crit Care 8:R251-60. 2004
    ..This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the association between the Consensus Conference criteria and outcome..
  5. ncbi Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia
    Manuel Iregui
    Pulmonary and Critical Care Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Chest 122:262-8. 2002
    ..To determine the influence of initially delayed appropriate antibiotic treatment (IDAAT) on the outcomes of patients with ventilator-associated pneumonia (VAP)...
  6. ncbi Pro- and synbiotics to control inflammation and infection in patients with multiple injuries
    Evangelos J Giamarellos-Bourboulis
    4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece
    J Trauma 67:815-21. 2009
    ..The mechanism of action of synbiotics was studied...
  7. ncbi Prolonged intensive care unit stay in cardiac surgery: risk factors and long-term-survival
    Ortrud Vargas Hein
    Department of Anesthesiology and Intensive Care Medicine, Campus Charite Mitte, Charite University Medicine Berlin, Berlin, Germany
    Ann Thorac Surg 81:880-5. 2006
    ....
  8. ncbi Lipopolysaccharide binding protein in a surgical intensive care unit: a marker of sepsis?
    Yasser Sakr
    Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
    Crit Care Med 36:2014-22. 2008
    ....
  9. ncbi Prediction about severity and outcome of sepsis by pro-atrial natriuretic peptide and pro-adrenomedullin
    Rui lan Wang
    First People s Hospital, Shanghai Jiaotong University, China
    Chin J Traumatol 13:152-7. 2010
    ....
  10. ncbi Routine use of the confusion assessment method for the intensive care unit: a multicenter study
    Maarten M van Eijk
    Department of Intensive Care Medicine, University Medical Center Utrecht, The Netherlands
    Am J Respir Crit Care Med 184:340-4. 2011
    ..The Confusion Assessment Method for the ICU (CAM-ICU) has high sensitivity and specificity for delirium when administered by research nurses. However, test characteristics of the CAM-ICU as performed in routine practice are unclear...
  11. ncbi Clinical characteristics and outcomes of obstetric patients requiring ICU admission
    Daniela N Vasquez
    Intensive Care Unit, Hospital Interzonal General de Agudos Gral, San Martin, 1 y 70, 1900 La Plata, Buenos Aires, Argentina
    Chest 131:718-24. 2007
    ..To review a series of critically ill obstetric patients admitted to our ICU to assess the spectrum of disease, required interventions, and fetal/maternal mortality, and to identify conditions associated with maternal death...
  12. pmc Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study
    Mirjam Christ-Crain
    Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 9:R816-24. 2005
    ..The aim of the present study was to evaluate the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) levels in a cohort of medical intensive care patients and to compare it with other biomarkers and physiological scores...
  13. ncbi Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes
    Jerry A Krishnan
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Chest 124:297-305. 2003
    ..To assess the consistency of caloric intake with American College of Chest Physicians (ACCP) recommendations for critically ill patients and to evaluate the relationship of caloric intake with clinical outcomes...
  14. ncbi One-year outcomes in survivors of the acute respiratory distress syndrome
    Margaret S Herridge
    Department of Medicine, University Health Network, Toronto, Ont, Canada
    N Engl J Med 348:683-93. 2003
    ..As more patients survive the acute respiratory distress syndrome, an understanding of the long-term outcomes of this condition is needed...
  15. ncbi Gender differences in human sepsis
    J Schroder
    Department of General and Thoracic Surgery, University of Kiel, Germany
    Arch Surg 133:1200-5. 1998
    ..In animal studies, gender differences were related to hormonal and immunologic changes that were associated with an increased susceptibility to sepsis in males...
  16. ncbi Gender-based differences in outcome in patients with sepsis
    S R Eachempati
    Department of Surgery, Weill Medical College of Cornell University, New York, NY, USA
    Arch Surg 134:1342-7. 1999
    ..This study tested the hypothesis that female patients admitted to the surgical intensive care unit with a documented infection have a lower mortality rate...
  17. ncbi Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patients
    Alenka Spindler-Vesel
    University Medical Centre, Ljubljana, Slovenia
    JPEN J Parenter Enteral Nutr 31:119-26. 2007
    ....
  18. ncbi Prognostic factors in obstetric patients admitted to an Indian intensive care unit
    Dilip R Karnad
    Medical Neurology Neurosurgery Intensive Care Unit, Seth G S Medical College and King Edward VII Memorial Hospital, Parel, Mumbai, India
    Crit Care Med 32:1294-9. 2004
    ..We studied the diseases requiring intensive care and prognostic factors in obstetric patients...
  19. ncbi Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients
    E Abraham
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    Crit Care Med 29:503-10. 2001
    ..There was no evidence that lenercept was detrimental in the overall population. CONCLUSION: Lenercept had no significant effect on mortality in the study population...
  20. ncbi A chart of failure risk for noninvasive ventilation in patients with COPD exacerbation
    M Confalonieri
    S C Pneumologia, Ospedale di Cattinara, Strada di Fiume, 447, I 34100 Trieste, Italy
    Eur Respir J 25:348-55. 2005
    ..Patients with a Glasgow Coma Score <11, acute physiology and chronic health evaluation (APACHE) II > or =29, respiratory rate > or =30 breaths x min(-1) and pH at admission <7...
  21. ncbi Recalibration of risk prediction models in a large multicenter cohort of admissions to adult, general critical care units in the United Kingdom
    David A Harrison
    Intensive Care National Audit and Research Centre, London, UK
    Crit Care Med 34:1378-88. 2006
    ..To assess the performance of published risk prediction models in common use in adult critical care in the United Kingdom and to recalibrate these models in a large representative database of critical care admissions...
  22. ncbi Critically Ill patients with 2009 influenza A(H1N1) in Mexico
    Guillermo Dominguez-Cherit
    Division of Pulmonary and Critical Care Dr Domínguez Cherit, Hospital Epidemiology Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    JAMA 302:1880-7. 2009
    ..In March 2009, novel 2009 influenza A(H1N1) was first reported in the southwestern United States and Mexico. The population and health care system in Mexico City experienced the first and greatest early burden of critical illness...
  23. ncbi Customized prediction models based on APACHE II and SAPS II scores in patients with prolonged length of stay in the ICU
    M Suistomaa
    Mikkeli Central Hospital, Finland
    Intensive Care Med 28:479-85. 2002
    To study customized APACHE II and SAPS II models in predicting hospital death in patients with a prolonged length of stay in the ICU.
  24. ncbi Combining sequential organ failure assessment (SOFA) score with acute physiology and chronic health evaluation (APACHE) II score to predict hospital mortality of critically ill patients
    K M Ho
    Intensive Care Unit, Department of Intensive Care, Royal Perth Hospital, Perth, Western Australia, Australia
    Anaesth Intensive Care 35:515-21. 2007
    ..showed that Sequential Organ Failure Assessment (SOFA) score and Acute Physiology and Chronic Health Evaluation (APACHE) II score can predict hospital mortality of critically ill patients...
  25. ncbi Early predictors of in-hospital death in infective endocarditis
    Vivian H Chu
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 109:1745-9. 2004
    ..Data on early determinants of outcome in infective endocarditis (IE) are limited. We evaluated the prognostic significance of early clinical characteristics in a large, prospective cohort of patients with IE...
  26. ncbi Hospital volume and the outcomes of mechanical ventilation
    Jeremy M Kahn
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle 98104, USA
    N Engl J Med 355:41-50. 2006
    ..The relationship between the number of patients admitted (hospital volume) and outcome among patients with critical illnesses is unknown...
  27. pmc Vitamin D deficiency is associated with mortality in the medical intensive care unit
    Sindhaghatta Venkatram
    Albert Einstein College of Medicine, Division of Pulmonary and Critical Care Medicine, Bronx Lebanon Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, USA
    Crit Care 15:R292. 2011
    ..The goal of the study was to evaluate the prevalence of 25-hydroxyvitamin D deficiency in the medical intensive care unit and its relationship with outcomes...
  28. ncbi Bacteremia, acute physiology and chronic health evaluation II and modified end stage liver disease are independent predictors of mortality in critically ill nontransplanted patients with acute on chronic liver failure
    Constantine J Karvellas
    Division of Critical Care Medicine, University of Alberta, Edmonton, Canada
    Crit Care Med 38:121-6. 2010
    ....
  29. ncbi RIFLE classification as predictive factor of mortality in patients with cirrhosis admitted to intensive care unit
    Evangelos Cholongitas
    The Royal Free Sheila Sherlock Liver Centre and Department of Surgery, Royal Free Hospital, Hampstead, London NW3 2QG, UK
    J Gastroenterol Hepatol 24:1639-47. 2009
    ..To evaluate the association of the Risk, Injury, Failure, Loss and End-stage renal failure (RIFLE) score on mortality in patients with decompensated cirrhosis admitted to intensive care unit (ICU)...
  30. ncbi Impact of appropriate antimicrobial therapy on mortality associated with Acinetobacter baumannii bacteremia: relation to severity of infection
    Yi Tzu Lee
    Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
    Clin Infect Dis 55:209-15. 2012
    ..This retrospective study was conducted to evaluate the effect of appropriate antimicrobial therapy on 14-day mortality after adjustment for multiple risk factors...
  31. ncbi Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients
    M H Kollef
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Chest 115:462-74. 1999
    ..To evaluate the relationship between inadequate antimicrobial treatment of infections (both community-acquired and nosocomial infections) and hospital mortality for patients requiring ICU admission...
  32. ncbi Vitamin D deficiency is associated with poor outcomes and increased mortality in severely ill patients
    Y Arnson
    Department of Medicine B, Sheba Medical Center, Tel Hashomer 52621, Israel
    QJM 105:633-9. 2012
    ..Vitamin D plays a seminal role in many homeostatic mechanisms. In this study, we assessed the correlation between circulating vitamin D levels and mortality rates in critically ill patients...
  33. ncbi Comparison of acute physiology and chronic health evaluations II and III and simplified acute physiology score II: a prospective cohort study evaluating these methods to predict outcome in a German interdisciplinary intensive care unit
    R Markgraf
    Department of Internal Medicine, Allgemeines Krankenhaus Hagen, University Witten Herdecke, Germany
    Crit Care Med 28:26-33. 2000
    ..To evaluate the ability of three scoring systems to predict hospital mortality in adult patients of an interdisciplinary intensive care unit in Germany...
  34. ncbi Validation of severity scoring systems SAPS II and APACHE II in a single-center population
    M Capuzzo
    Department of Surgical, Anesthetic and Radiological Sciences, University Hospital of Ferrara, Italy
    Intensive Care Med 26:1779-85. 2000
    To validate two severity scoring systems, the Simplified Acute Physiology Score (SAPS II) and Acute Physiology and Chronic Health Evaluation (APACHE II), in a single-center ICU population.
  35. ncbi Performance of the third-generation models of severity scoring systems (APACHE IV, SAPS 3 and MPM-III) in acute kidney injury critically ill patients
    Verônica Torres Costa e Silva
    Division of Nephrology, University of Sao Paulo School of Medicine, Sao Paulo, Brasil
    Nephrol Dial Transplant 26:3894-901. 2011
    ..scoring systems [simplified acute physiology score (SAPS) 3, acute physiology and chronic health evaluation (APACHE) IV and mortality probability model (MPM)-III] in acute kidney injury (AKI) patients in the intensive care unit (..
  36. ncbi APACHE: an evaluation
    Megan M Wheeler
    Intermediate Care Unit, St David s Medical Center, Austin, Texas, USA
    Crit Care Nurs Q 32:46-8. 2009
    A cursory evaluation of the Acute Physiology and Chronic Health Evaluation, commonly known as the APACHE scoring system, validates its relevancy as the most widely used method for assessing severity and prognosis in intensive care unit ..
  37. ncbi Value of APACHE II, SOFA and CPIS scores in predicting prognosis in patients with ventilator-associated pneumonia
    Gul Gursel
    Pulmonary Diseases Department, Intensive Care Unit, Gazi University School of Medicine, Besevler, Ankara, Turkey
    Respiration 73:503-8. 2006
    ..Ventilator-associated pneumonia (VAP) is the most frequent infection with high mortality rates in intensive care units (ICUs) and the prediction of outcome is important in the decision-making process...
  38. pmc The outcomes of using colistin for treating multidrug resistant Acinetobacter species bloodstream infections
    Seung Kwan Lim
    Department of Respiratory and Critical Care Medicine, Ajou University School of Medicine, Suwon, Korea
    J Korean Med Sci 26:325-31. 2011
    ..This result suggests that administering colistin, although it is the sole microbiologically appropriate agent, does not influence the 30 day mortality of patients with a MDR Acinetobacter spp. bloodstream infection...
  39. ncbi APACHE-II scoring system in perforative peritonitis
    Srikanth V Kulkarni
    Department of General Surgery, M S Ramaiah Medical College and Teaching Hospital, Bangalore 560 054 Karnataka, India
    Am J Surg 194:549-52. 2007
    Prospective assessment of the Acute Physiology and Chronic Health Evaluation-II (APACHE-II) scoring system of stratification of disease severity has been shown to provide objective discrimination between low-risk and high-risk groups of ..
  40. ncbi Obesity increases the severity of acute pancreatitis: performance of APACHE-O score and correlation with the inflammatory response
    Georgios I Papachristou
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Pancreatology 6:279-85. 2006
    Obese patients appear to be at risk for complications of acute pancreatitis (AP). APACHE-O score has been suggested to improve APACHE-II accuracy in predicting severe outcome in AP.
  41. ncbi Inter-observer variability in APACHE II scoring: effect of strict guidelines and training
    K H Polderman
    Surgical Intensive Care Unit, University Hospital Vrije Universiteit, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Intensive Care Med 27:1365-9. 2001
    To assess the effect of strict guidelines and a rigorous training program on variability in scoring the revised Acute Physiology and Chronic Health Evaluation (APACHE II).
  42. ncbi Poisoning severity score, APACHE II and GCS: effective clinical indices for estimating severity and predicting outcome of acute organophosphorus and carbamate poisoning
    Kishore Gnana Sam
    Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India
    J Forensic Leg Med 16:239-47. 2009
    ..The Glasgow coma scale (GCS) scores, acute physiology and chronic health evaluation II (APACHE II) scores, predicted mortality rate (PMR) and Poisoning severity score (PSS) were estimated within 24h of ..
  43. pmc Mortality probability model III and simplified acute physiology score II: assessing their value in predicting length of stay and comparison to APACHE IV
    Eduard E Vasilevskis
    Philip R Lee Institute for Health Policy Studies, Division of General Internal Medicine, Hospital Medicine, University of California atSan Francisco, CA, USA
    Chest 136:89-101. 2009
    ..To develop and compare ICU length-of-stay (LOS) risk-adjustment models using three commonly used mortality or LOS prediction models...
  44. ncbi Anemia and blood transfusion in critically ill patients
    Jean Louis Vincent
    Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, 1070, Belgium
    JAMA 288:1499-507. 2002
    ..Anemia is a common problem in critically ill patients admitted to intensive care units (ICUs), but the consequences of anemia on morbidity and mortality in the critically ill is poorly defined...
  45. ncbi Early intervention can improve clinical outcome of acute interstitial pneumonia
    Gee Young Suh
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul 135 710, South Korea
    Chest 129:753-61. 2006
    ....
  46. pmc Significance of lipopolysaccharide-binding protein (an acute phase protein) in monitoring critically ill patients
    Miroslav Prucha
    Staff, Department of Clinical Biochemistry, Hematology and Immunology, Hospital Na Homolce, Czech Republic
    Crit Care 7:R154-9. 2003
    ....
  47. ncbi Prospective cohort study comparing sequential organ failure assessment and acute physiology, age, chronic health evaluation III scoring systems for hospital mortality prediction in critically ill cirrhotic patients
    Y C Chen
    Division of Critical Care Nephrology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Int J Clin Pract 60:160-6. 2006
    ..usefulness of sequential organ failure assessment (SOFA) and acute physiology, age, chronic health evaluation III (APACHE III) scoring systems obtained on the first day of intensive care unit (ICU) admission in predicting hospital ..
  48. pmc The impact of duration of organ dysfunction on the outcome of patients with severe sepsis and septic shock
    Flávio G R Freitas
    Disciplina de Anestesiologia, Dor e Terapia Intensiva, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
    Clinics (Sao Paulo) 63:483-8. 2008
    ..This study aimed to assess the impact of the duration of organ dysfunction on the outcome of patients with severe sepsis or septic shock...
  49. ncbi Protocolized intensive care unit management of analgesia, sedation, and delirium improves analgesia and subsyndromal delirium rates
    Yoanna Skrobik
    Hopital Maisonneuve Rosemont, 5415 blvd de l Assomption, Montreal, QC, Canada H1T 2M4
    Anesth Analg 111:451-63. 2010
    ..We hypothesized that the likely reduction in iatrogenic coma would result in less delirium, because these 2 morbid conditions seem to be linked...
  50. ncbi Necrotizing soft tissue infections: APACHE II score, dissemination, and survival
    Tuncay Yilmazlar
    Department of General Surgery, Uludag University School of Medicine, Gorukle Kampusu, Bursa, 21900, Turkey
    World J Surg 31:1858-62. 2007
    ..The aim of this study was to elucidate the factors affecting the outcome of patients presenting with an NSTI...
  51. ncbi Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit
    E Wesley Ely
    Department of Medicine, Division of General Internal Medicine and Center for Health Services Research and the Veterans Affairs Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, Tenn, USA
    JAMA 291:1753-62. 2004
    ..In the intensive care unit (ICU), delirium is a common yet underdiagnosed form of organ dysfunction, and its contribution to patient outcomes is unclear...
  52. ncbi Diastolic filling in human severe sepsis: an echocardiographic study
    B Munt
    University of British Columbia and Vancouver Hospital and Health Science Center, BC, Canada
    Crit Care Med 26:1829-33. 1998
    ..To determine if nonsurvivors have a more abnormal pattern of left ventricular relaxation than survivors with severe sepsis...
  53. ncbi Acute Physiology and Chronic Health Evaluation (APACHE) IV: hospital mortality assessment for today's critically ill patients
    Jack E Zimmerman
    George Washington University, Washington, DC, USA
    Crit Care Med 34:1297-310. 2006
    To improve the accuracy of the Acute Physiology and Chronic Health Evaluation (APACHE) method for predicting hospital mortality among critically ill adults and to evaluate changes in the accuracy of earlier APACHE models.
  54. pmc Effect of noninvasive mechanical ventilation in elderly patients with hypercapnic acute-on-chronic respiratory failure and a do-not-intubate order
    Paolo Scarpazza
    Divisione di Broncopneumotisiologia, Ospedale Civile, Vimercate, Italy
    Int J Chron Obstruct Pulmon Dis 3:797-801. 2008
    ..9%. Negative prognostic factors for NIMV response proved to be: an older age, a low Glasgow Coma Score, a high APACHE score at admission, a high PaCO2 after 12 hours and a low pH both after 1 and 12 hours of NIMV...
  55. ncbi Serum procalcitonin at the time of admission to the ICU as a predictor of short-term mortality
    Fan Su Meng
    ICU, General Hospital of Guangzhou Military Command, 111 Liu Hua Road, Yue Xiu District, Guangzhou, China
    Clin Biochem 42:1025-31. 2009
    ..This purpose of this study was to determine if serum procalcitonin (PCT) concentration at the time of admission to the ICU is a predictor of all-cause short-term mortality...
  56. ncbi Prediction of patient outcome from Acinetobacter baumannii bacteremia with Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II scores
    Su Jung Chen
    Department of Medicine, National Yang Ming University Hospital, Taiwan
    Intern Med 50:871-7. 2011
    ..We aimed to assess the effectiveness of SOFA and APACHE II scores calculated at the onset of bacteremia in predicting the mortality of patients with A...
  57. pmc Intra-abdominal hypertension in patients with severe acute pancreatitis
    Jan J De Waele
    Intensive Care Unit, Ghent University Hospital, Gent, Belgium
    Crit Care 9:R452-7. 2005
    ..We therefore studied patient factors associated with the development of intra-abdominal hypertension (IAH), the incidence of organ failure associated with IAH, and the effect on outcome in patients with severe acute pancreatitis (SAP)...
  58. ncbi Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)
    E W Ely
    Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, 6th Floor Medical Center East 6109, Vanderbilt University Medical Center, Nashville, TN 37323 8300, USA
    JAMA 286:2703-10. 2001
    ..Delirium is a common problem in the intensive care unit (ICU). Accurate diagnosis is limited by the difficulty of communicating with mechanically ventilated patients and by lack of a validated delirium instrument for use in the ICU...
  59. ncbi Outcome predictors and new score of critically ill cirrhotic patients with acute renal failure
    Ji Tseng Fang
    Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Nephrol Dial Transplant 23:1961-9. 2008
    ..This work seeks to identify specific predictors of hospital mortality in critically ill cirrhotic patients with acute renal failure...
  60. ncbi Oxidative stress in critically ill patients with systemic inflammatory response syndrome
    José M Alonso de Vega
    Intensive Care Unit, Hospital Naval del Mediterráneo, Cartagena, Spain
    Crit Care Med 30:1782-6. 2002
    ..To evaluate whether critically ill patients with systemic inflammatory response syndrome, on admission to an intensive care unit, had more severe oxidative stress than those without this syndrome...
  61. ncbi Predicting the result of noninvasive ventilation in severe acute exacerbations of patients with chronic airflow limitation
    A Anton
    Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Chest 117:828-33. 2000
    ....
  62. ncbi Key process indicators of mortality in the implementation of protocol-driven therapy for severe sepsis
    Jiun Long Wang
    Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    J Formos Med Assoc 108:778-87. 2009
    ..We implemented protocol-driven therapy for severe sepsis, and analyzed retrospectively the key process indicators of mortality in managing sepsis...
  63. pmc Electrical muscle stimulation preserves the muscle mass of critically ill patients: a randomized study
    Vasiliki Gerovasili
    First Critical Care Department, Evangelismos Hospital, National and Kapodistrian University of Athens, 45 47 Ypsilantou Str, 106 75 Athens, Greece
    Crit Care 13:R161. 2009
    ..The aim of our study was to investigate the EMS effects on muscle mass preservation of critically ill patients with the use of ultrasonography (US)...
  64. ncbi Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis
    Jose Garnacho-Montero
    Hospital Universitario Virgen del Rocio, Sevilla, Spain
    Crit Care Med 31:2742-51. 2003
    ..The impact of adequate empirical antibiotic therapy on early (<3 days), 28-day, and 60-day mortality rates also was assessed. We determined the risk factors for inadequate empirical antibiotic therapy. DESIGN Prospective cohort study...
  65. ncbi Risk factors for intensive care delirium: a systematic review
    Bart Van Rompaey
    University of Antwerp, Division of Nursing Science and Midwifery, Belgium
    Intensive Crit Care Nurs 24:98-107. 2008
    ..The APACHE II score and hypertension were the only factors reported twice...
  66. ncbi Interrater reliability of APACHE II scores for medical-surgical intensive care patients: a prospective blinded study
    Michelle E Kho
    Health Research Methodology Program, at McMaster University, Hamilton, Ontario, Canada
    Am J Crit Care 16:378-83. 2007
    Despite widespread use of the Acute Physiology and Chronic Health Evaluation II (APACHE II), its interrater reliability has not been well studied.
  67. ncbi APACHE system is better than Ranson system in the prediction of severity of acute pancreatitis
    Yuk Pang Yeung
    Department of Surgery, Kwong Wah Hospital, 25 Waterloo Road, Kowloon, Hong Kong, China
    Hepatobiliary Pancreat Dis Int 5:294-9. 2006
    It has been suggested that addition of obesity score to the APACHE-II system can lead to more accurate prediction of severity of acute pancreatitis...
  68. ncbi Ventilator-dependent survivors of catastrophic illness transferred to 23 long-term care hospitals for weaning from prolonged mechanical ventilation
    David J Scheinhorn
    Barlow Respiratory Hospital and Research Center, 2000 Stadium Way, Los Angeles, CA 90026, USA
    Chest 131:76-84. 2007
    ..This multicenter study was undertaken to characterize the population of ventilator-dependent patients admitted to long-term care hospitals (LTCHs) for weaning from mechanical ventilation...
  69. ncbi A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients
    Sean M Bagshaw
    Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, Alberta T6G2B7, Canada
    Nephrol Dial Transplant 23:1203-10. 2008
    ..We sought to evaluate the RIFLE criteria on the day of ICU admission in a large heterogenous population of critically ill patients...
  70. ncbi Blood component use in critically ill patients
    M P Rao
    National Blood Service Brentwood Centre, Crescent Drive, Brentwood, Essex CM1 8DP, UK
    Anaesthesia 57:530-4. 2002
    ..This study showed that transfusion practice is consistent and that in general there does not seem to be an excessive use of blood components in critically ill patients...
  71. ncbi Effect of postpyloric feeding on gastroesophageal regurgitation and pulmonary microaspiration: results of a randomized controlled trial
    D K Heyland
    Department of Medicine, Kingston General Hospital, Queen s University, 76 Stuart Street, Kingston, Ontario, KVL 2V7, Canada
    Crit Care Med 29:1495-501. 2001
    ..To determine the extent to which postpyloric feeding reduces gastroesophageal regurgitation and pulmonary microaspiration in critically ill patients...
  72. ncbi Computed tomography severity index, APACHE II score, and serum CRP concentration for predicting the severity of acute pancreatitis
    Gunay Gurleyik
    Department of Surgery, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
    JOP 6:562-7. 2005
    ..A highly accurate system which could predict the severity and identify the local extent and complications of a serious inflammation, is beneficial for patient outcome...
  73. ncbi Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases?
    P C Hebert
    Critical Care Programs, University of Ottawa, Ottawa, ON, Canada
    Crit Care Med 29:227-34. 2001
    ..To compare a restrictive red blood cell transfusion strategy with a more liberal strategy in volume-resuscitated critically ill patients with cardiovascular disease...
  74. pmc Comparison of APACHE III, APACHE IV, SAPS 3, and MPM0III and influence of resuscitation status on model performance
    Mark T Keegan
    Division of Critical Care, Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
    Chest 142:851-8. 2012
    There are few comparisons among the most recent versions of the major adult ICU prognostic systems (APACHE [Acute Physiology and Chronic Health Evaluation] IV, Simplified Acute Physiology Score [SAPS] 3, Mortality Probability Model [MPM]..
  75. pmc Utility of Procalcitonin (PCT) and Mid regional pro-Adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in Emergency Department (ED). A comparison with APACHE II score
    Francesco Travaglino
    Emergency Department Azienda Ospedaliera Sant Andrea, School of Medicine and Psychology Sapienza Univesity, Rome, Italy
    BMC Infect Dis 12:184. 2012
    ..evaluate the prognostic value of MR-proADM and PCT levels in febrile patients in the ED in comparison with a disease severity index score, the APACHE II score. We also evaluated the ability of MR-proADM and PCT to predict hospitalization.
  76. ncbi Comparison of acute physiology and chronic health evaluation II death risk, Child-Pugh, Charlson, and model for end-stage liver disease indexes to predict early mortality after liver transplantation
    A Basile-Filho
    Intensive Care Division, Department of Surgery and Anatomy, Ribeirão Preto University of São Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Transplant Proc 43:1660-4. 2011
    ..This study sought to determine which prognostic index was the most efficient to predict early (1-month) mortality of patients undergoing orthotopic liver transplantation (OLT)...
  77. ncbi Accuracy of a composite score using daily SAPS II and LOD scores for predicting hospital mortality in ICU patients hospitalized for more than 72 h
    J F Timsit
    Réanimation des maladies infectieuses, Hĵpital Bichat Claude Bernard, Paris, France
    Intensive Care Med 27:1012-21. 2001
    ..Consequently, these scores are not the most appropriate tools for measuring prognosis in studies dealing with ICU patients hospitalized for more than 72 h...
  78. ncbi Serum cystatin C for prediction of dialysis requirement or death in acute kidney injury: a comparative study
    Mary C Perianayagam
    Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, MA 02135, USA
    Am J Kidney Dis 54:1025-33. 2009
    ..However, its utility and performance in patients with acute kidney injury (AKI), particularly for the prediction of dialysis requirement, is not well known...
  79. ncbi APACHE IV versus PPI for predicting community hospital ICU mortality
    Shaffer R Shrope-Mok
    Jackson Park Hospital Department of Geriatrics, Wound Care and Palliative Care, Chicago, IL, USA
    Am J Hosp Palliat Care 27:243-7. 2010
    Both the Acute Physiology and Chronic Health Evaluation (APACHE) IV and Palliative Performance Index (PPI) are scales used to estimate intensive care unit (ICU) prognosis and mortality.
  80. ncbi Accepting critically ill transfer patients: adverse effect on a referral center's outcome and benchmark measures
    Andrew L Rosenberg
    University of Michigan and the Department of Veterans Affairs Health Services Research and Development Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan 48109 0048, USA
    Ann Intern Med 138:882-90. 2003
    ..With the most sophisticated and validated set of case-mix measures available for patients, the intensive care unit is an ideal setting in which to study the effect of a patient's being transferred from another hospital...
  81. ncbi King's criteria, APACHE II, and SOFA scores in acute liver failure
    Evangelos B Cholongitas
    Hepatology 43:881; author reply 882. 2006
  82. pmc Revisiting the validity of APACHE II in the trauma ICU: improved risk stratification in critically injured adults
    Lesly A Dossett
    Division of Trauma and Surgical Critical Care, Department of Surgery, Vanderbilt University Medical Center, 404 Medical Arts Building, Nashville, TN 37212, USA
    Injury 40:993-8. 2009
    ..While the Acute Physiologic and Chronic Health Evaluation (APACHE) II score has been considered "invalid" in the trauma population, we hypothesized that APAHCE II would more ..
  83. ncbi Increasing reliability of APACHE II scores in a medical-surgical intensive care unit: a quality improvement study
    Laura Donahoe
    Dalhousie University in Halifax, Nova Scotia, Canada
    Am J Crit Care 18:58-64. 2009
    Given their clinical, research, and administrative purposes, scores on the Acute Physiology and Chronic Health Evaluation (APACHE) II should be reliable, whether calculated by health care personnel or a clinical information system.
  84. ncbi Comparison of serum procalcitonin with Ranson, APACHE-II, Glasgow and Balthazar CT severity index scores in predicting severity of acute pancreatitis
    Su Mi Woo
    Department of Internal Medicine, Dong A University College of Medicine, Busan, Korea
    Korean J Gastroenterol 58:31-7. 2011
    ..The aim of this study is to assess serum procalcitonin (PCT) for early prediction of severe acute pancreatitis compared with multiple scoring systems and biomarkers...
  85. ncbi Comparison of the severity of illness scoring systems for critically ill cirrhotic patients with renal failure
    Y C Chen
    Division of Critical Care Nephrology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
    Clin Nephrol 61:111-8. 2004
    ..is aimed to compare the predicting ability of acute physiology, age, chronic health evaluation II and III (APACHE II and III), sequential organ failure assessment (SOFA), and Child-Pugh scoring systems, obtained on the first day ..
  86. ncbi Error rates among clinical pharmacists in calculating the APACHE II score
    Bonnie Greenwood
    Department of Pharmacy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pharmacotherapy 27:285-9. 2007
    ..Many institutions have adopted an Acute Physiology and Chronic Health Evaluation (APACHE) II cutoff score of 25 (i.e...
  87. ncbi The use of benchmarking to identify top performing critical care units: a preliminary assessment of their policies and practices
    Jack E Zimmerman
    Department of Anesthesiology and Critical Care Medicine, The George Washington University, Washington, DC, USA
    J Crit Care 18:76-86. 2003
    ..To describe the policies and practices of intensive care units (ICUs) with good patient survival and highly efficient resource use and to identify relevant variables for future investigation...
  88. ncbi Clinical value of APACHE scores in patients who require intensive care before liver transplantation
    Kwang Min Park
    Division of HBP Surgery and Liver Transplantation, Department of Surgery, University of Ulsan College of Medicine, Seoul, Korea
    Hepatogastroenterology 55:2135-9. 2008
    ..The APACHE scoring system, which reflects a patient's clinical course, may be a better prognostic indicator of outcomes after ..
  89. ncbi Predisposing factors for critical illness polyneuromyopathy in a multidisciplinary intensive care unit
    S Nanas
    National and Kapodistrian University, Medical School, First Critical Care Department, Evangelismos Hospital, Athens, Greece
    Acta Neurol Scand 118:175-81. 2008
    ..To investigate risk factors of critical illness polyneuromyopathy (CIPM) in a general multidisciplinary intensive care unit (ICU)...
  90. ncbi Hemodynamics and metabolic studies on septic shock in patients with acute liver failure
    Ming Hung Tsai
    Division of Gastroenterology, Chang Gung Memorial Hospital, Chang Gung University, Taipei 105, Taiwan
    J Crit Care 23:468-72. 2008
    ..Acute liver failure is often accompanied by hyperdynamic circulation, which is also a characteristic of septic shock. Pre-existing acute liver failure may worsen the hemodynamic impairment and prognosis in sepsis...
  91. pmc The value of procalcitonin and the SAPS II and APACHE III scores in the differentiation of infectious and non-infectious fever in the ICU: a prospective, cohort study
    Eun Ju Jeon
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea
    J Korean Med Sci 25:1633-7. 2010
    ..Simplified Acute Physiology Score (SAPS) II and Acute Physiology And Chronic Health Evaluation (APACHE) III scores were also analyzed. Sixty-three patients developed fever among 448 consecutive patients (14.1%)...
  92. ncbi Aggressive hepatic resection for patients with pyogenic liver abscess and APACHE II score > or =15
    Huan Fa Hsieh
    Division of General Surgery, Department of Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Am J Surg 196:346-50. 2008
    ..The aim of this study was to evaluate the results of hepatic resection (HR) for patients with pyogenic liver abscesses and an Acute Physiology and Chronic Health Evaluation II (APACHE II) score > or =15.
  93. ncbi [Prognostic systems in intensive care: TRISS, SAPS II, APACHE III]
    S Barbieri
    Dipartimento di Farmacologia ed Anestesiologia, Egidio Meneghetti, Sede di Anestesiologia e Rianimazione, , Padova, Italy
    Minerva Anestesiol 67:519-38. 2001
    BACKGROUND: To validate the accuracy of SAPS II, APACHE III and TRISS for the prediction of mortality in Intensive Care Unit (ICU) at polytrauma patients admission...
  94. ncbi Admission lactate level and the APACHE II score are the most useful predictors of prognosis following torso trauma
    Ahmet Kessaf Aslar
    Department of Surgery, Ankara Numune Hospital, ehit cetin Görgü S Ugur A 17 3, Maltepe, Ankara 06570, Turkey
    Injury 35:746-52. 2004
    ..Moreover, to assess if any of the admission parameters can be used to indicate outcome...
  95. ncbi Impact of inappropriate antimicrobial therapy on outcome in patients with hospital-acquired pneumonia caused by Acinetobacter baumannii
    Mi Kyong Joung
    Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    J Infect 61:212-8. 2010
    ..The purpose of this study was to evaluate the impact of inappropriate antimicrobial therapy on the outcome of patients with hospital-acquired pneumonia (HAP) caused by Acinetobacter baumannii...
  96. ncbi Predicting mortality in patients suffering from prolonged critical illness: an assessment of four severity-of-illness measures
    S S Carson
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Chest 120:928-33. 2001
    Investigators have been using severity-of-illness indexes such as APACHE II (acute physiology and chronic health evaluation score II) to describe patients with prolonged critical illness...
  97. ncbi APACHE II scoring system is superior in the prediction of the outcome in critically ill patients with perforative peritonitis
    Samir Delibegovic
    Department of Surgery, University Clinic Center Tuzla, University of Tuzla, Bosnia and Herzegovina
    Med Arh 65:82-5. 2011
    ..This study was undertaken to evaluate APACHE II, SAPS I, Sepsis score, MOF, TISS-28 and MPI scoring systems in prediction of the outcome in patients with ..
  98. ncbi Evidence-based clinical practice guidelines for acute pancreatitis: proposals
    Toshihiko Mayumi
    Department of Emergency Medicine and Intensive Care, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8560, Japan
    J Hepatobiliary Pancreat Surg 9:413-22. 2002
    ..To provide a framework for clinicians to manage acute pancreatitis, evidence-based guidelines have been developed by the Japanese Society of Abdominal Emergency Medicine...
  99. ncbi Comparison of Ranson, APACHE II and APACHE III scoring systems in acute pancreatitis
    Constantinos Chatzicostas
    Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
    Pancreas 25:331-5. 2002
    ..Acute pancreatitis runs an unpredictable course. The early prediction of the severity of an acute attack has important implications for management and timely intervention...
  100. ncbi APACHE II and SAPS II are poorly calibrated in a Hong Kong intensive care unit
    I K Tan
    Intensive Care Unit, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong SAR, People s Republic of China
    Ann Acad Med Singapore 27:318-22. 1998
    This study seeks to determine if the Acute Physiology and Chronic Health Evaluation II (APACHE II) and the new Simplified Acute Physiology Score (SAPS II) model predictions are well calibrated in our adult Intensive Care Unit (ICU) ..
  101. ncbi Survival and outcome prediction using the Apache III and the out-of-hospital cardiac arrest (OHCA) score in patients treated in the intensive care unit (ICU) following out-of-hospital, in-hospital or ICU cardiac arrest
    M B Skrifvars
    Intensive Care Unit, Liverpool Hospital, Sydney, Australia
    Resuscitation 83:728-33. 2012
    ..We investigated survival, factors associated with survival and the correlation and accuracy of general and specific scoring systems, including the Apache III score and the OHCA score in OHCA, IHCA and ICUCA patients.

Research Grants63

  1. Predicting persistent Organ Failure early in Acute Pancreatitis
    Georgios I Papachristou; Fiscal Year: 2013
    ..C-reactive protein) and 7 scoring systems (Ranson's, acute physiology and chronic health examination-II or APACHE-II, Glasgow, systemic inflammatory response syndrome, bedside index for severity in acute pancreatitis, Panc 3, ..
  2. The MIND USA Study
    E Wesley Ely; Fiscal Year: 2012
    ..to detect the effect of antipsychotics in 4 important subgroups including age >65 years, severity of illness (APACHE II >25), severe sepsis at enrollment, and medical vs...
  3. OpenLIS: The Development of a Clinical Laboratory Information System Using the Op
    ROGER ALLAN HUBBARD; Fiscal Year: 2010
    ..The Linux operating system, Apache web server, Firefox web browser, MySQL database are just some examples of such successes...
  4. Mechanisms and Population Genomics of Pneumococcal Antigenic Diversity
    Marc Lipsitch; Fiscal Year: 2013
    ..We will perform whole genome sequencing of 800 pneumococcal isolates from a defined population (Navajo and Apache in the US Southwest) and apply the measures defined in Aim 1 to assess the evidence that each gene in the genome ..
  5. Plasma Protein Biomarker-Based Diagnostics Of Outcome In Sepsis and CAP
    STEPHEN FRANCIS KINGSMORE; Fiscal Year: 2010
    ..The biomarker panel will be compared with prognostic indices, such as metabolic endpoints and APACHE II score...
  6. Investigation of Cloud Computing to Support Data-Parallel Health Research
    Geoffrey C Fox; Fiscal Year: 2010
    ..Example technologies include Microsoft Dryad and Apache Hadoop...
  7. Impact of PCV on disease and colonization among Native American communities
    KATHERINE LOUISE O'BRIEN; Fiscal Year: 2013
    ..Within the United States some Native American groups, like the Navajo and the White Mountain Apache tribes, suffer from pneumococcal disease much more often than people in the general US population...
  8. PARP inhibitor therapy for septic shock
    Andrew Salzman; Fiscal Year: 2004
    ..Secondary clinical endpoints will be reductions in 1) 28-day all cause mortality, 2) duration of ICU stay, 3) APACHE II index...
  9. BRIDGE TO THE BACCALAUREATE PROGRAM AT NEW MEXICO STATE UNIVERSITY
    Barbara A Lyons; Fiscal Year: 2013
    ..These institutions enroll 5,414 AI students from the Din[unreadable] (Navajo) Nation, the Jicarilla Apache Nation, and eight Pueblos in New Mexico...
  10. Bridging Arizona Native American Students to Bachelor Degrees
    JANI CHERI INGRAM; Fiscal Year: 2013
    ..is ideal since Flagstaff is considered a border town for the Navajo and Hopi Nations and near the White River Apache and Hualapai Nations...
  11. DELIRIUM IN PERSONS WITH DEMENTIA
    Donna Fick; Fiscal Year: 2007
    ..Katz ADL Scale, Lawton Instrumental Activities of Daily Living Scale (IADL), Charlson Co-morbidity Index, Apache II, the Clinical Dementia Rating scale (CDR), a family semi-structured interview form, and a Modified Blessed ..
  12. PROPHOLAXIS OF H. INFLUENZAE AND OTHER INFECTIONS
    Mathuram Santosham; Fiscal Year: 1991
    ..We will also compare the ability of Apache and Caucasians of various ages to make an antibody response to bacterial polysaccharide vaccines and search for ..
  13. Optimizing Risk-Adjustment for Measuring ICU Quality
    Laurent Glance; Fiscal Year: 2002
    ..likely that ICU scoring systems will behave in the same manner; Specific Aim #1 will examine this hypothesis for APACHE 11 (Acute Physiology and Chronic Health Evaluation), SAPS 11 (Simplified Acute Physiology Score) and MPM II (..
  14. PHYSIOLOGIC OUTCOMES OF POSITIONING IN ACUTE HEAD TRAUMA
    Jacqueline Sullivan; Fiscal Year: 2000
    ..Injury Severity SCores, (ISS) and Apache III Scores are treated as covariates in this study...
  15. IMPROVING OUTCOMES IN MECHANICALLY VENTILATED PATIENTS
    Leslie Hoffman; Fiscal Year: 2003
    ..capillary wedge pressure estimated non-invasively [ePCWP], acute physiology and chronic health evaluation [APACHE] III scores; 4) information needs (Patient/Family Information Needs Scale); 5) ICU resource consumption (ratio of ..
  16. Post-acute Care and Functional Recovery after Hospitalization
    Susan Hardy; Fiscal Year: 2009
    ..This future index, like an APACHE score, could support prognostic and ultimately treatment guidelines for care of medically complex, recently ..
  17. PLANNING GRANT--DIABETES/NEPHROPATHY IN APACHE INDIANS
    W Walker; Fiscal Year: 1991
    ..The planning effort for which support is requested will be focused upon a study of the White Mountain Apache reservation...
  18. METHODOLOGIC STUDIES ON APACHE III
    WILLIAM KNAUS; Fiscal Year: 1991
    ..This project will extend the development and application of the APACHE (Acute Physiology and Chronic Health Evaluation) severity of illness classification system to the analysis and ..
  19. Assessing and Treating Symptoms of Dying ICU Patients
    Kathleen Puntillo; Fiscal Year: 2006
    ..Patient illness acuity levels will be calculated per APACHE II, and nurse-patient staffing ratios, hospital site, and patient's DNR status will be recorded...
  20. GENE LINKAGE STUDY OF IMMUNODEFICIENCY IN NAVAJO INDIANS
    Morton Cowan; Fiscal Year: 2001
    ..Immunodeficiency Disease (SCID) is found with increased incidence among Athabascan-speaking (A-SCID), Navajo, Apache, and Dine' Native Americans. Cowan and his colleagues have recently mapped the A-SCID gene to a 2...
  21. The Effect of Patient Volume on Outcome in the ICU
    Jeremy Kahn; Fiscal Year: 2006
    ..To test this hypothesis, the APACHE III database will be used to compare risk-adjusted mortality and ICU length of stay across participating ICUs...
  22. PATHWAYS--FULL SCALE STUDY
    June Stevens; Fiscal Year: 2000
    ..forty schools from six American Indian nations are involved: Pima/Maricopa, Tohono O'odham, Navajo, White Mountain Apache, Oglala Lakota, and Sicangu Lakota...
  23. PATHWAYS--PREVENTION OF OBESITY AMONG NAVAJO YOUTH
    Sally Davis; Fiscal Year: 2000
    ..six American Indian nations are involved: Gila River tribal preference) Tohono O'odham, Navajo, White Mountain Apache, Oglala lakota, and Sicangu Lakota...
  24. PATHWAYS--FULL SCALE STUDY
    Benjamin Caballero; Fiscal Year: 2000
    ..forty schools from six American Indian nations are involved: Pima/Maricopa, Tohono O'odham, Navajo, White Mountain Apache, Oglala Lakota, and Sicangu Lakota...
  25. Open-source Science Education Software on the Web
    Paul Wright; Fiscal Year: 2001
    ..of the most successful and fastest growing software is open-source (such as the Linux operating system, and the Apache web server)...
  26. SEARCH for Diabetes in Youth 2: Colorado Center
    Dana Dabelea; Fiscal Year: 2009
    ..These include: the Navajo Nation, the White Mountain Apache Reservation and the Gila River Pima Reservation...
  27. Impact of Psychoactive Drugs on Delirium in ICU Patients
    Margaret Pisani; Fiscal Year: 2008
    ..Ultimately, we hope this work will lead to the development of specific interventions in ICU drug therapy vital to the care of more than four million critically ill patients in the United States. ..
  28. Are Volume Standards Accurate Measures of Quality?
    Laurent Glance; Fiscal Year: 2005
    ..abstract_text> ..
  29. Feasibility of Measuring Sleep in a Critical Care Environment
    Margaret A Pisani; Fiscal Year: 2010
    ....
  30. PREDICTIVE RISK MODEL IN ACUTE ISCHEMIC STROKE
    Karen Johnston; Fiscal Year: 2004
    ..This will be valuable to patients with stroke, providers, payers and developers of new drug therapies. ..
  31. Identification of Green Tea Polyphenol-Targeted Genes
    Stephen Hsu; Fiscal Year: 2004
    ..Data generated from this proposal may reveal novel drug targets for treatment of head and neck cancer. ..
  32. TRIAL OF ACTIVITY FOR ADOLESCENT GIRLS (TAAG)
    Timothy Lohman; Fiscal Year: 2005
    ..The team brings expertise in PA program design, PA and fitness assessment, formative assessment, behavior theory and curriculum development, intervention delivery, process evaluation, and data management. ..
  33. RISK FACTORS & BIOMARKERS OF OX STRESS IN GRAFT FAILURE
    Jason Christie; Fiscal Year: 2004
    ..abstract_text> ..
  34. PERIPHERAL CANNABINOIDS AND NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2002
    ..This knowledge base may provide a rationale for developing peripherally-selective cannabinoid analgesics with minimal CNS-mediated side-effect liability. ..
  35. The MIND ICU Study
    E Wesley Ely; Fiscal Year: 2010
    ....
  36. Hospital and Community Acquired Acute Renal Failure
    Glenn Chertow; Fiscal Year: 2006
    ..This study will efficiently inform the Nephrology community by providing a foundation of fundamental information (ARF definitions, incidence, consequences and costs) upon which a clinical trials network can be built. ..
  37. TRIAL OF FAS PREVENTION IN AMERICAN INDIAN COMMUNITIES
    Philip May; Fiscal Year: 2001
    ..Furthermore, prevention protocols, research techniques and methods, will test the recommendations of the IOM report and should also be applicable to non-Indian communities as well. ..
  38. Project PROTECT II
    Gordon Bernard; Fiscal Year: 2003
    ..abstract_text> ..
  39. Cannabinoid Modulation of Capsaicin-Sensitive Nociceptors
    Kenneth M Hargreaves; Fiscal Year: 2010
    ..Second, identification of cannabinoid modulation of pain via TRPchannels provides a rationale for a novel class of analgesics that are devoid of classical cannabinoid side effects. ..
  40. Neuropeptide Y Regulation of Peripheral Human Nociceptors and Pain
    Kenneth Hargreaves; Fiscal Year: 2007
    ..Moreover, our study population in South Texas permits secondary analyses of a potentially underserved population (predominantly Hispanic) that is at risk for caries-induced pulpal necrosis and pain. [unreadable] [unreadable]..
  41. Cognitive Impairment in the ICU: Evaluation and Outcomes
    E Ely; Fiscal Year: 2005
    ..Along with the candidate's record of publications and achievement, he will have rich academic surroundings, excellent mentors and strong institutional commitment to ensure that he achieve these goals. ..
  42. Glucose Regulation in Acute Stroke Patients (GRASP)
    Karen Johnston; Fiscal Year: 2007
    ....
  43. Immuno-modulatory Effects of Parenteral Nutrition After Intestinal Failure
    Stephen Benedict; Fiscal Year: 2007
    ..The data obtained will position the research team to develop more mechanistically in-depth RO1 proposals that investigate human patients and a murine PN animal model. [unreadable] [unreadable] [unreadable]..
  44. Exploring Measurement of Palliative Care Quality in ICUs
    Judith Nelson; Fiscal Year: 2008
    ..N/A [unreadable] [unreadable] [unreadable]..
  45. Galectin-3 and Expression of the Asthma Phenotype
    Craig Lilly; Fiscal Year: 2008
    ..These studies will provide new insights into the complex role of lectins and their ligands in allergic diseases. ..
  46. Biomarker Profiles in the Diagnosis/Prognosis of ARDS
    Lorraine Ware; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  47. Prostaglandins, Leukotrienes, and Innate Immunity
    Craig Lilly; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  48. Sedation Effects in Mechanically Ventilated Patients
    Mary Jo Grap; Fiscal Year: 2009
    ..abstract_text> ..
  49. Mouse model for sepsis
    H Warren; Fiscal Year: 2009
    ..abstract_text> ..
  50. Depressive Symptoms, Aging, Disability and Health Outcomes
    Kenneth Covinsky; Fiscal Year: 2009
    ....
  51. The Effect of Hypertonic Resuscitation for Blunt Trauma
    Eileen Bulger; Fiscal Year: 2005
    ..abstract_text> ..
  52. Long Term Outcomes in ICU Patients: Delirium & Apolipoprotein E
    Sheila Alexander; Fiscal Year: 2009
    ..This would likely lead to decreased time in the ICU and hospital. ..
  53. Hypertonic Modulation of Inflammation following Injury
    Eileen M Bulger; Fiscal Year: 2010
    ..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..