Genomes and Genes
Summary: An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.
Publications354 found, 100 shown here
- Sepsis in European intensive care units: results of the SOAP studyJean Louis Vincent
Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
Crit Care Med 34:344-53. 2006..To better define the incidence of sepsis and the characteristics of critically ill patients in European intensive care units...
- Early goal-directed therapy in the treatment of severe sepsis and septic shockE Rivers
Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
N Engl J Med 345:1368-77. 2001..The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit...
- ESPEN Guidelines on Enteral Nutrition: Intensive careK G Kreymann
Department of Intensive Care Medicine, University Hospital Eppendorf, Hamburg, Germany
Clin Nutr 25:210-23. 2006..There is no general indication for immune-modulating formulae in patients with severe illness or sepsis and an APACHE II Score >15. Glutamine should be supplemented in patients suffering from burns or trauma.
- Brazilian Sepsis Epidemiological Study (BASES study)Eliezer Silva
Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
Crit Care 8:R251-60. 2004..This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the association between the Consensus Conference criteria and outcome..
- Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumoniaManuel Iregui
Pulmonary and Critical Care Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Chest 122:262-8. 2002..To determine the influence of initially delayed appropriate antibiotic treatment (IDAAT) on the outcomes of patients with ventilator-associated pneumonia (VAP)...
- Pro- and synbiotics to control inflammation and infection in patients with multiple injuriesEvangelos J Giamarellos-Bourboulis
4th Department of Internal Medicine, University of Athens, Medical School, Athens, Greece
J Trauma 67:815-21. 2009..The mechanism of action of synbiotics was studied...
- Prolonged intensive care unit stay in cardiac surgery: risk factors and long-term-survivalOrtrud Vargas Hein
Department of Anesthesiology and Intensive Care Medicine, Campus Charite Mitte, Charite University Medicine Berlin, Berlin, Germany
Ann Thorac Surg 81:880-5. 2006....
- Lipopolysaccharide binding protein in a surgical intensive care unit: a marker of sepsis?Yasser Sakr
Department of Anesthesiology and Intensive Care, Friedrich Schiller University Hospital, Jena, Germany
Crit Care Med 36:2014-22. 2008....
- Prediction about severity and outcome of sepsis by pro-atrial natriuretic peptide and pro-adrenomedullinRui lan Wang
First People s Hospital, Shanghai Jiaotong University, China
Chin J Traumatol 13:152-7. 2010....
- Routine use of the confusion assessment method for the intensive care unit: a multicenter studyMaarten M van Eijk
Department of Intensive Care Medicine, University Medical Center Utrecht, The Netherlands
Am J Respir Crit Care Med 184:340-4. 2011..The Confusion Assessment Method for the ICU (CAM-ICU) has high sensitivity and specificity for delirium when administered by research nurses. However, test characteristics of the CAM-ICU as performed in routine practice are unclear...
- Clinical characteristics and outcomes of obstetric patients requiring ICU admissionDaniela N Vasquez
Intensive Care Unit, Hospital Interzonal General de Agudos Gral, San Martin, 1 y 70, 1900 La Plata, Buenos Aires, Argentina
Chest 131:718-24. 2007..To review a series of critically ill obstetric patients admitted to our ICU to assess the spectrum of disease, required interventions, and fetal/maternal mortality, and to identify conditions associated with maternal death...
- Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational studyMirjam Christ-Crain
Department of Internal Medicine, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
Crit Care 9:R816-24. 2005..The aim of the present study was to evaluate the prognostic value of mid-regional pro-adrenomedullin (MR-proADM) levels in a cohort of medical intensive care patients and to compare it with other biomarkers and physiological scores...
- Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomesJerry A Krishnan
Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Chest 124:297-305. 2003..To assess the consistency of caloric intake with American College of Chest Physicians (ACCP) recommendations for critically ill patients and to evaluate the relationship of caloric intake with clinical outcomes...
- One-year outcomes in survivors of the acute respiratory distress syndromeMargaret S Herridge
Department of Medicine, University Health Network, Toronto, Ont, Canada
N Engl J Med 348:683-93. 2003..As more patients survive the acute respiratory distress syndrome, an understanding of the long-term outcomes of this condition is needed...
- Gender differences in human sepsisJ Schroder
Department of General and Thoracic Surgery, University of Kiel, Germany
Arch Surg 133:1200-5. 1998..In animal studies, gender differences were related to hormonal and immunologic changes that were associated with an increased susceptibility to sepsis in males...
- Gender-based differences in outcome in patients with sepsisS R Eachempati
Department of Surgery, Weill Medical College of Cornell University, New York, NY, USA
Arch Surg 134:1342-7. 1999..This study tested the hypothesis that female patients admitted to the surgical intensive care unit with a documented infection have a lower mortality rate...
- Synbiotics, prebiotics, glutamine, or peptide in early enteral nutrition: a randomized study in trauma patientsAlenka Spindler-Vesel
University Medical Centre, Ljubljana, Slovenia
JPEN J Parenter Enteral Nutr 31:119-26. 2007....
- Prognostic factors in obstetric patients admitted to an Indian intensive care unitDilip R Karnad
Medical Neurology Neurosurgery Intensive Care Unit, Seth G S Medical College and King Edward VII Memorial Hospital, Parel, Mumbai, India
Crit Care Med 32:1294-9. 2004..We studied the diseases requiring intensive care and prognostic factors in obstetric patients...
- Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patientsE Abraham
Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
Crit Care Med 29:503-10. 2001..There was no evidence that lenercept was detrimental in the overall population. CONCLUSION: Lenercept had no significant effect on mortality in the study population...
- A chart of failure risk for noninvasive ventilation in patients with COPD exacerbationM Confalonieri
S C Pneumologia, Ospedale di Cattinara, Strada di Fiume, 447, I 34100 Trieste, Italy
Eur Respir J 25:348-55. 2005..Patients with a Glasgow Coma Score <11, acute physiology and chronic health evaluation (APACHE) II > or =29, respiratory rate > or =30 breaths x min(-1) and pH at admission <7...
- Recalibration of risk prediction models in a large multicenter cohort of admissions to adult, general critical care units in the United KingdomDavid A Harrison
Intensive Care National Audit and Research Centre, London, UK
Crit Care Med 34:1378-88. 2006..To assess the performance of published risk prediction models in common use in adult critical care in the United Kingdom and to recalibrate these models in a large representative database of critical care admissions...
- Critically Ill patients with 2009 influenza A(H1N1) in MexicoGuillermo Dominguez-Cherit
Division of Pulmonary and Critical Care Dr Domínguez Cherit, Hospital Epidemiology Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
JAMA 302:1880-7. 2009..In March 2009, novel 2009 influenza A(H1N1) was first reported in the southwestern United States and Mexico. The population and health care system in Mexico City experienced the first and greatest early burden of critical illness...
- Customized prediction models based on APACHE II and SAPS II scores in patients with prolonged length of stay in the ICUM Suistomaa
Mikkeli Central Hospital, Finland
Intensive Care Med 28:479-85. 2002To study customized APACHE II and SAPS II models in predicting hospital death in patients with a prolonged length of stay in the ICU.
- Combining sequential organ failure assessment (SOFA) score with acute physiology and chronic health evaluation (APACHE) II score to predict hospital mortality of critically ill patientsK M Ho
Intensive Care Unit, Department of Intensive Care, Royal Perth Hospital, Perth, Western Australia, Australia
Anaesth Intensive Care 35:515-21. 2007..showed that Sequential Organ Failure Assessment (SOFA) score and Acute Physiology and Chronic Health Evaluation (APACHE) II score can predict hospital mortality of critically ill patients...
- Early predictors of in-hospital death in infective endocarditisVivian H Chu
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Circulation 109:1745-9. 2004..Data on early determinants of outcome in infective endocarditis (IE) are limited. We evaluated the prognostic significance of early clinical characteristics in a large, prospective cohort of patients with IE...
- Hospital volume and the outcomes of mechanical ventilationJeremy M Kahn
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle 98104, USA
N Engl J Med 355:41-50. 2006..The relationship between the number of patients admitted (hospital volume) and outcome among patients with critical illnesses is unknown...
- Vitamin D deficiency is associated with mortality in the medical intensive care unitSindhaghatta Venkatram
Albert Einstein College of Medicine, Division of Pulmonary and Critical Care Medicine, Bronx Lebanon Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, USA
Crit Care 15:R292. 2011..The goal of the study was to evaluate the prevalence of 25-hydroxyvitamin D deficiency in the medical intensive care unit and its relationship with outcomes...
- Bacteremia, acute physiology and chronic health evaluation II and modified end stage liver disease are independent predictors of mortality in critically ill nontransplanted patients with acute on chronic liver failureConstantine J Karvellas
Division of Critical Care Medicine, University of Alberta, Edmonton, Canada
Crit Care Med 38:121-6. 2010....
- RIFLE classification as predictive factor of mortality in patients with cirrhosis admitted to intensive care unitEvangelos Cholongitas
The Royal Free Sheila Sherlock Liver Centre and Department of Surgery, Royal Free Hospital, Hampstead, London NW3 2QG, UK
J Gastroenterol Hepatol 24:1639-47. 2009..To evaluate the association of the Risk, Injury, Failure, Loss and End-stage renal failure (RIFLE) score on mortality in patients with decompensated cirrhosis admitted to intensive care unit (ICU)...
- Impact of appropriate antimicrobial therapy on mortality associated with Acinetobacter baumannii bacteremia: relation to severity of infectionYi Tzu Lee
Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan
Clin Infect Dis 55:209-15. 2012..This retrospective study was conducted to evaluate the effect of appropriate antimicrobial therapy on 14-day mortality after adjustment for multiple risk factors...
- Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patientsM H Kollef
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
Chest 115:462-74. 1999..To evaluate the relationship between inadequate antimicrobial treatment of infections (both community-acquired and nosocomial infections) and hospital mortality for patients requiring ICU admission...
- Vitamin D deficiency is associated with poor outcomes and increased mortality in severely ill patientsY Arnson
Department of Medicine B, Sheba Medical Center, Tel Hashomer 52621, Israel
QJM 105:633-9. 2012..Vitamin D plays a seminal role in many homeostatic mechanisms. In this study, we assessed the correlation between circulating vitamin D levels and mortality rates in critically ill patients...
- Comparison of acute physiology and chronic health evaluations II and III and simplified acute physiology score II: a prospective cohort study evaluating these methods to predict outcome in a German interdisciplinary intensive care unitR Markgraf
Department of Internal Medicine, Allgemeines Krankenhaus Hagen, University Witten Herdecke, Germany
Crit Care Med 28:26-33. 2000..To evaluate the ability of three scoring systems to predict hospital mortality in adult patients of an interdisciplinary intensive care unit in Germany...
- Validation of severity scoring systems SAPS II and APACHE II in a single-center populationM Capuzzo
Department of Surgical, Anesthetic and Radiological Sciences, University Hospital of Ferrara, Italy
Intensive Care Med 26:1779-85. 2000To validate two severity scoring systems, the Simplified Acute Physiology Score (SAPS II) and Acute Physiology and Chronic Health Evaluation (APACHE II), in a single-center ICU population.
- Performance of the third-generation models of severity scoring systems (APACHE IV, SAPS 3 and MPM-III) in acute kidney injury critically ill patientsVerônica Torres Costa e Silva
Division of Nephrology, University of Sao Paulo School of Medicine, Sao Paulo, Brasil
Nephrol Dial Transplant 26:3894-901. 2011..scoring systems [simplified acute physiology score (SAPS) 3, acute physiology and chronic health evaluation (APACHE) IV and mortality probability model (MPM)-III] in acute kidney injury (AKI) patients in the intensive care unit (..
- APACHE: an evaluationMegan M Wheeler
Intermediate Care Unit, St David s Medical Center, Austin, Texas, USA
Crit Care Nurs Q 32:46-8. 2009A cursory evaluation of the Acute Physiology and Chronic Health Evaluation, commonly known as the APACHE scoring system, validates its relevancy as the most widely used method for assessing severity and prognosis in intensive care unit ..
- Value of APACHE II, SOFA and CPIS scores in predicting prognosis in patients with ventilator-associated pneumoniaGul Gursel
Pulmonary Diseases Department, Intensive Care Unit, Gazi University School of Medicine, Besevler, Ankara, Turkey
Respiration 73:503-8. 2006..Ventilator-associated pneumonia (VAP) is the most frequent infection with high mortality rates in intensive care units (ICUs) and the prediction of outcome is important in the decision-making process...
- The outcomes of using colistin for treating multidrug resistant Acinetobacter species bloodstream infectionsSeung Kwan Lim
Department of Respiratory and Critical Care Medicine, Ajou University School of Medicine, Suwon, Korea
J Korean Med Sci 26:325-31. 2011..This result suggests that administering colistin, although it is the sole microbiologically appropriate agent, does not influence the 30 day mortality of patients with a MDR Acinetobacter spp. bloodstream infection...
- APACHE-II scoring system in perforative peritonitisSrikanth V Kulkarni
Department of General Surgery, M S Ramaiah Medical College and Teaching Hospital, Bangalore 560 054 Karnataka, India
Am J Surg 194:549-52. 2007Prospective assessment of the Acute Physiology and Chronic Health Evaluation-II (APACHE-II) scoring system of stratification of disease severity has been shown to provide objective discrimination between low-risk and high-risk groups of ..
- Obesity increases the severity of acute pancreatitis: performance of APACHE-O score and correlation with the inflammatory responseGeorgios I Papachristou
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Pancreatology 6:279-85. 2006Obese patients appear to be at risk for complications of acute pancreatitis (AP). APACHE-O score has been suggested to improve APACHE-II accuracy in predicting severe outcome in AP.
- Inter-observer variability in APACHE II scoring: effect of strict guidelines and trainingK H Polderman
Surgical Intensive Care Unit, University Hospital Vrije Universiteit, P O Box 7057, 1007 MB Amsterdam, The Netherlands
Intensive Care Med 27:1365-9. 2001To assess the effect of strict guidelines and a rigorous training program on variability in scoring the revised Acute Physiology and Chronic Health Evaluation (APACHE II).
- Poisoning severity score, APACHE II and GCS: effective clinical indices for estimating severity and predicting outcome of acute organophosphorus and carbamate poisoningKishore Gnana Sam
Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India
J Forensic Leg Med 16:239-47. 2009..The Glasgow coma scale (GCS) scores, acute physiology and chronic health evaluation II (APACHE II) scores, predicted mortality rate (PMR) and Poisoning severity score (PSS) were estimated within 24h of ..
- Mortality probability model III and simplified acute physiology score II: assessing their value in predicting length of stay and comparison to APACHE IVEduard E Vasilevskis
Philip R Lee Institute for Health Policy Studies, Division of General Internal Medicine, Hospital Medicine, University of California atSan Francisco, CA, USA
Chest 136:89-101. 2009..To develop and compare ICU length-of-stay (LOS) risk-adjustment models using three commonly used mortality or LOS prediction models...
- Anemia and blood transfusion in critically ill patientsJean Louis Vincent
Department of Intensive Care, Erasme University Hospital, Route de Lennik 808, Brussels, 1070, Belgium
JAMA 288:1499-507. 2002..Anemia is a common problem in critically ill patients admitted to intensive care units (ICUs), but the consequences of anemia on morbidity and mortality in the critically ill is poorly defined...
- Early intervention can improve clinical outcome of acute interstitial pneumoniaGee Young Suh
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon dong, Gangnam Gu, Seoul 135 710, South Korea
Chest 129:753-61. 2006....
- Significance of lipopolysaccharide-binding protein (an acute phase protein) in monitoring critically ill patientsMiroslav Prucha
Staff, Department of Clinical Biochemistry, Hematology and Immunology, Hospital Na Homolce, Czech Republic
Crit Care 7:R154-9. 2003....
- Prospective cohort study comparing sequential organ failure assessment and acute physiology, age, chronic health evaluation III scoring systems for hospital mortality prediction in critically ill cirrhotic patientsY C Chen
Division of Critical Care Nephrology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
Int J Clin Pract 60:160-6. 2006..usefulness of sequential organ failure assessment (SOFA) and acute physiology, age, chronic health evaluation III (APACHE III) scoring systems obtained on the first day of intensive care unit (ICU) admission in predicting hospital ..
- The impact of duration of organ dysfunction on the outcome of patients with severe sepsis and septic shockFlávio G R Freitas
Disciplina de Anestesiologia, Dor e Terapia Intensiva, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil
Clinics (Sao Paulo) 63:483-8. 2008..This study aimed to assess the impact of the duration of organ dysfunction on the outcome of patients with severe sepsis or septic shock...
- Protocolized intensive care unit management of analgesia, sedation, and delirium improves analgesia and subsyndromal delirium ratesYoanna Skrobik
Hopital Maisonneuve Rosemont, 5415 blvd de l Assomption, Montreal, QC, Canada H1T 2M4
Anesth Analg 111:451-63. 2010..We hypothesized that the likely reduction in iatrogenic coma would result in less delirium, because these 2 morbid conditions seem to be linked...
- Necrotizing soft tissue infections: APACHE II score, dissemination, and survivalTuncay Yilmazlar
Department of General Surgery, Uludag University School of Medicine, Gorukle Kampusu, Bursa, 21900, Turkey
World J Surg 31:1858-62. 2007..The aim of this study was to elucidate the factors affecting the outcome of patients presenting with an NSTI...
- Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unitE Wesley Ely
Department of Medicine, Division of General Internal Medicine and Center for Health Services Research and the Veterans Affairs Tennessee Valley Geriatric Research, Education and Clinical Center, Nashville, Tenn, USA
JAMA 291:1753-62. 2004..In the intensive care unit (ICU), delirium is a common yet underdiagnosed form of organ dysfunction, and its contribution to patient outcomes is unclear...
- Diastolic filling in human severe sepsis: an echocardiographic studyB Munt
University of British Columbia and Vancouver Hospital and Health Science Center, BC, Canada
Crit Care Med 26:1829-33. 1998..To determine if nonsurvivors have a more abnormal pattern of left ventricular relaxation than survivors with severe sepsis...
- Acute Physiology and Chronic Health Evaluation (APACHE) IV: hospital mortality assessment for today's critically ill patientsJack E Zimmerman
George Washington University, Washington, DC, USA
Crit Care Med 34:1297-310. 2006To improve the accuracy of the Acute Physiology and Chronic Health Evaluation (APACHE) method for predicting hospital mortality among critically ill adults and to evaluate changes in the accuracy of earlier APACHE models.
- Effect of noninvasive mechanical ventilation in elderly patients with hypercapnic acute-on-chronic respiratory failure and a do-not-intubate orderPaolo Scarpazza
Divisione di Broncopneumotisiologia, Ospedale Civile, Vimercate, Italy
Int J Chron Obstruct Pulmon Dis 3:797-801. 2008..9%. Negative prognostic factors for NIMV response proved to be: an older age, a low Glasgow Coma Score, a high APACHE score at admission, a high PaCO2 after 12 hours and a low pH both after 1 and 12 hours of NIMV...
- Serum procalcitonin at the time of admission to the ICU as a predictor of short-term mortalityFan Su Meng
ICU, General Hospital of Guangzhou Military Command, 111 Liu Hua Road, Yue Xiu District, Guangzhou, China
Clin Biochem 42:1025-31. 2009..This purpose of this study was to determine if serum procalcitonin (PCT) concentration at the time of admission to the ICU is a predictor of all-cause short-term mortality...
- Prediction of patient outcome from Acinetobacter baumannii bacteremia with Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II scoresSu Jung Chen
Department of Medicine, National Yang Ming University Hospital, Taiwan
Intern Med 50:871-7. 2011..We aimed to assess the effectiveness of SOFA and APACHE II scores calculated at the onset of bacteremia in predicting the mortality of patients with A...
- Intra-abdominal hypertension in patients with severe acute pancreatitisJan J De Waele
Intensive Care Unit, Ghent University Hospital, Gent, Belgium
Crit Care 9:R452-7. 2005..We therefore studied patient factors associated with the development of intra-abdominal hypertension (IAH), the incidence of organ failure associated with IAH, and the effect on outcome in patients with severe acute pancreatitis (SAP)...
- Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU)E W Ely
Division of Allergy Pulmonary Critical Care Medicine, Center for Health Services Research, 6th Floor Medical Center East 6109, Vanderbilt University Medical Center, Nashville, TN 37323 8300, USA
JAMA 286:2703-10. 2001..Delirium is a common problem in the intensive care unit (ICU). Accurate diagnosis is limited by the difficulty of communicating with mechanically ventilated patients and by lack of a validated delirium instrument for use in the ICU...
- Outcome predictors and new score of critically ill cirrhotic patients with acute renal failureJi Tseng Fang
Department of Nephrology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
Nephrol Dial Transplant 23:1961-9. 2008..This work seeks to identify specific predictors of hospital mortality in critically ill cirrhotic patients with acute renal failure...
- Oxidative stress in critically ill patients with systemic inflammatory response syndromeJosé M Alonso de Vega
Intensive Care Unit, Hospital Naval del Mediterráneo, Cartagena, Spain
Crit Care Med 30:1782-6. 2002..To evaluate whether critically ill patients with systemic inflammatory response syndrome, on admission to an intensive care unit, had more severe oxidative stress than those without this syndrome...
- Predicting the result of noninvasive ventilation in severe acute exacerbations of patients with chronic airflow limitationA Anton
Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
Chest 117:828-33. 2000....
- Key process indicators of mortality in the implementation of protocol-driven therapy for severe sepsisJiun Long Wang
Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
J Formos Med Assoc 108:778-87. 2009..We implemented protocol-driven therapy for severe sepsis, and analyzed retrospectively the key process indicators of mortality in managing sepsis...
- Electrical muscle stimulation preserves the muscle mass of critically ill patients: a randomized studyVasiliki Gerovasili
First Critical Care Department, Evangelismos Hospital, National and Kapodistrian University of Athens, 45 47 Ypsilantou Str, 106 75 Athens, Greece
Crit Care 13:R161. 2009..The aim of our study was to investigate the EMS effects on muscle mass preservation of critically ill patients with the use of ultrasonography (US)...
- Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsisJose Garnacho-Montero
Hospital Universitario Virgen del Rocio, Sevilla, Spain
Crit Care Med 31:2742-51. 2003..The impact of adequate empirical antibiotic therapy on early (<3 days), 28-day, and 60-day mortality rates also was assessed. We determined the risk factors for inadequate empirical antibiotic therapy. DESIGN Prospective cohort study...
- Risk factors for intensive care delirium: a systematic reviewBart Van Rompaey
University of Antwerp, Division of Nursing Science and Midwifery, Belgium
Intensive Crit Care Nurs 24:98-107. 2008..The APACHE II score and hypertension were the only factors reported twice...
- Interrater reliability of APACHE II scores for medical-surgical intensive care patients: a prospective blinded studyMichelle E Kho
Health Research Methodology Program, at McMaster University, Hamilton, Ontario, Canada
Am J Crit Care 16:378-83. 2007Despite widespread use of the Acute Physiology and Chronic Health Evaluation II (APACHE II), its interrater reliability has not been well studied.
- APACHE system is better than Ranson system in the prediction of severity of acute pancreatitisYuk Pang Yeung
Department of Surgery, Kwong Wah Hospital, 25 Waterloo Road, Kowloon, Hong Kong, China
Hepatobiliary Pancreat Dis Int 5:294-9. 2006It has been suggested that addition of obesity score to the APACHE-II system can lead to more accurate prediction of severity of acute pancreatitis...
- Ventilator-dependent survivors of catastrophic illness transferred to 23 long-term care hospitals for weaning from prolonged mechanical ventilationDavid J Scheinhorn
Barlow Respiratory Hospital and Research Center, 2000 Stadium Way, Los Angeles, CA 90026, USA
Chest 131:76-84. 2007..This multicenter study was undertaken to characterize the population of ventilator-dependent patients admitted to long-term care hospitals (LTCHs) for weaning from mechanical ventilation...
- A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patientsSean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, Alberta T6G2B7, Canada
Nephrol Dial Transplant 23:1203-10. 2008..We sought to evaluate the RIFLE criteria on the day of ICU admission in a large heterogenous population of critically ill patients...
- Blood component use in critically ill patientsM P Rao
National Blood Service Brentwood Centre, Crescent Drive, Brentwood, Essex CM1 8DP, UK
Anaesthesia 57:530-4. 2002..This study showed that transfusion practice is consistent and that in general there does not seem to be an excessive use of blood components in critically ill patients...
- Effect of postpyloric feeding on gastroesophageal regurgitation and pulmonary microaspiration: results of a randomized controlled trialD K Heyland
Department of Medicine, Kingston General Hospital, Queen s University, 76 Stuart Street, Kingston, Ontario, KVL 2V7, Canada
Crit Care Med 29:1495-501. 2001..To determine the extent to which postpyloric feeding reduces gastroesophageal regurgitation and pulmonary microaspiration in critically ill patients...
- Computed tomography severity index, APACHE II score, and serum CRP concentration for predicting the severity of acute pancreatitisGunay Gurleyik
Department of Surgery, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey
JOP 6:562-7. 2005..A highly accurate system which could predict the severity and identify the local extent and complications of a serious inflammation, is beneficial for patient outcome...
- Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases?P C Hebert
Critical Care Programs, University of Ottawa, Ottawa, ON, Canada
Crit Care Med 29:227-34. 2001..To compare a restrictive red blood cell transfusion strategy with a more liberal strategy in volume-resuscitated critically ill patients with cardiovascular disease...
- Comparison of APACHE III, APACHE IV, SAPS 3, and MPM0III and influence of resuscitation status on model performanceMark T Keegan
Division of Critical Care, Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA
Chest 142:851-8. 2012There are few comparisons among the most recent versions of the major adult ICU prognostic systems (APACHE [Acute Physiology and Chronic Health Evaluation] IV, Simplified Acute Physiology Score [SAPS] 3, Mortality Probability Model [MPM]..
- Utility of Procalcitonin (PCT) and Mid regional pro-Adrenomedullin (MR-proADM) in risk stratification of critically ill febrile patients in Emergency Department (ED). A comparison with APACHE II scoreFrancesco Travaglino
Emergency Department Azienda Ospedaliera Sant Andrea, School of Medicine and Psychology Sapienza Univesity, Rome, Italy
BMC Infect Dis 12:184. 2012..evaluate the prognostic value of MR-proADM and PCT levels in febrile patients in the ED in comparison with a disease severity index score, the APACHE II score. We also evaluated the ability of MR-proADM and PCT to predict hospitalization.
- Comparison of acute physiology and chronic health evaluation II death risk, Child-Pugh, Charlson, and model for end-stage liver disease indexes to predict early mortality after liver transplantationA Basile-Filho
Intensive Care Division, Department of Surgery and Anatomy, Ribeirão Preto University of São Paulo, Ribeirao Preto, Sao Paulo, Brazil
Transplant Proc 43:1660-4. 2011..This study sought to determine which prognostic index was the most efficient to predict early (1-month) mortality of patients undergoing orthotopic liver transplantation (OLT)...
- Accuracy of a composite score using daily SAPS II and LOD scores for predicting hospital mortality in ICU patients hospitalized for more than 72 hJ F Timsit
Réanimation des maladies infectieuses, Hĵpital Bichat Claude Bernard, Paris, France
Intensive Care Med 27:1012-21. 2001..Consequently, these scores are not the most appropriate tools for measuring prognosis in studies dealing with ICU patients hospitalized for more than 72 h...
- Serum cystatin C for prediction of dialysis requirement or death in acute kidney injury: a comparative studyMary C Perianayagam
Department of Medicine, Division of Nephrology, Kidney and Dialysis Research Laboratory, St Elizabeth s Medical Center, Boston, MA 02135, USA
Am J Kidney Dis 54:1025-33. 2009..However, its utility and performance in patients with acute kidney injury (AKI), particularly for the prediction of dialysis requirement, is not well known...
- APACHE IV versus PPI for predicting community hospital ICU mortalityShaffer R Shrope-Mok
Jackson Park Hospital Department of Geriatrics, Wound Care and Palliative Care, Chicago, IL, USA
Am J Hosp Palliat Care 27:243-7. 2010Both the Acute Physiology and Chronic Health Evaluation (APACHE) IV and Palliative Performance Index (PPI) are scales used to estimate intensive care unit (ICU) prognosis and mortality.
- Accepting critically ill transfer patients: adverse effect on a referral center's outcome and benchmark measuresAndrew L Rosenberg
University of Michigan and the Department of Veterans Affairs Health Services Research and Development Service, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan 48109 0048, USA
Ann Intern Med 138:882-90. 2003..With the most sophisticated and validated set of case-mix measures available for patients, the intensive care unit is an ideal setting in which to study the effect of a patient's being transferred from another hospital...
- King's criteria, APACHE II, and SOFA scores in acute liver failureEvangelos B Cholongitas
Hepatology 43:881; author reply 882. 2006
- Revisiting the validity of APACHE II in the trauma ICU: improved risk stratification in critically injured adultsLesly A Dossett
Division of Trauma and Surgical Critical Care, Department of Surgery, Vanderbilt University Medical Center, 404 Medical Arts Building, Nashville, TN 37212, USA
Injury 40:993-8. 2009..While the Acute Physiologic and Chronic Health Evaluation (APACHE) II score has been considered "invalid" in the trauma population, we hypothesized that APAHCE II would more ..
- Increasing reliability of APACHE II scores in a medical-surgical intensive care unit: a quality improvement studyLaura Donahoe
Dalhousie University in Halifax, Nova Scotia, Canada
Am J Crit Care 18:58-64. 2009Given their clinical, research, and administrative purposes, scores on the Acute Physiology and Chronic Health Evaluation (APACHE) II should be reliable, whether calculated by health care personnel or a clinical information system.
- Comparison of serum procalcitonin with Ranson, APACHE-II, Glasgow and Balthazar CT severity index scores in predicting severity of acute pancreatitisSu Mi Woo
Department of Internal Medicine, Dong A University College of Medicine, Busan, Korea
Korean J Gastroenterol 58:31-7. 2011..The aim of this study is to assess serum procalcitonin (PCT) for early prediction of severe acute pancreatitis compared with multiple scoring systems and biomarkers...
- Comparison of the severity of illness scoring systems for critically ill cirrhotic patients with renal failureY C Chen
Division of Critical Care Nephrology, Chang Gung Memorial Hospital, Chang Gung University, Taipei, Taiwan
Clin Nephrol 61:111-8. 2004..is aimed to compare the predicting ability of acute physiology, age, chronic health evaluation II and III (APACHE II and III), sequential organ failure assessment (SOFA), and Child-Pugh scoring systems, obtained on the first day ..
- Error rates among clinical pharmacists in calculating the APACHE II scoreBonnie Greenwood
Department of Pharmacy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Pharmacotherapy 27:285-9. 2007..Many institutions have adopted an Acute Physiology and Chronic Health Evaluation (APACHE) II cutoff score of 25 (i.e...
- The use of benchmarking to identify top performing critical care units: a preliminary assessment of their policies and practicesJack E Zimmerman
Department of Anesthesiology and Critical Care Medicine, The George Washington University, Washington, DC, USA
J Crit Care 18:76-86. 2003..To describe the policies and practices of intensive care units (ICUs) with good patient survival and highly efficient resource use and to identify relevant variables for future investigation...
- Clinical value of APACHE scores in patients who require intensive care before liver transplantationKwang Min Park
Division of HBP Surgery and Liver Transplantation, Department of Surgery, University of Ulsan College of Medicine, Seoul, Korea
Hepatogastroenterology 55:2135-9. 2008..The APACHE scoring system, which reflects a patient's clinical course, may be a better prognostic indicator of outcomes after ..
- Predisposing factors for critical illness polyneuromyopathy in a multidisciplinary intensive care unitS Nanas
National and Kapodistrian University, Medical School, First Critical Care Department, Evangelismos Hospital, Athens, Greece
Acta Neurol Scand 118:175-81. 2008..To investigate risk factors of critical illness polyneuromyopathy (CIPM) in a general multidisciplinary intensive care unit (ICU)...
- Hemodynamics and metabolic studies on septic shock in patients with acute liver failureMing Hung Tsai
Division of Gastroenterology, Chang Gung Memorial Hospital, Chang Gung University, Taipei 105, Taiwan
J Crit Care 23:468-72. 2008..Acute liver failure is often accompanied by hyperdynamic circulation, which is also a characteristic of septic shock. Pre-existing acute liver failure may worsen the hemodynamic impairment and prognosis in sepsis...
- The value of procalcitonin and the SAPS II and APACHE III scores in the differentiation of infectious and non-infectious fever in the ICU: a prospective, cohort studyEun Ju Jeon
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea
J Korean Med Sci 25:1633-7. 2010..Simplified Acute Physiology Score (SAPS) II and Acute Physiology And Chronic Health Evaluation (APACHE) III scores were also analyzed. Sixty-three patients developed fever among 448 consecutive patients (14.1%)...
- Aggressive hepatic resection for patients with pyogenic liver abscess and APACHE II score > or =15Huan Fa Hsieh
Division of General Surgery, Department of Surgery, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
Am J Surg 196:346-50. 2008..The aim of this study was to evaluate the results of hepatic resection (HR) for patients with pyogenic liver abscesses and an Acute Physiology and Chronic Health Evaluation II (APACHE II) score > or =15.
- [Prognostic systems in intensive care: TRISS, SAPS II, APACHE III]S Barbieri
Dipartimento di Farmacologia ed Anestesiologia, Egidio Meneghetti, Sede di Anestesiologia e Rianimazione, , Padova, Italy
Minerva Anestesiol 67:519-38. 2001BACKGROUND: To validate the accuracy of SAPS II, APACHE III and TRISS for the prediction of mortality in Intensive Care Unit (ICU) at polytrauma patients admission...
- Admission lactate level and the APACHE II score are the most useful predictors of prognosis following torso traumaAhmet Kessaf Aslar
Department of Surgery, Ankara Numune Hospital, ehit cetin Görgü S Ugur A 17 3, Maltepe, Ankara 06570, Turkey
Injury 35:746-52. 2004..Moreover, to assess if any of the admission parameters can be used to indicate outcome...
- Impact of inappropriate antimicrobial therapy on outcome in patients with hospital-acquired pneumonia caused by Acinetobacter baumanniiMi Kyong Joung
Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
J Infect 61:212-8. 2010..The purpose of this study was to evaluate the impact of inappropriate antimicrobial therapy on the outcome of patients with hospital-acquired pneumonia (HAP) caused by Acinetobacter baumannii...
- Predicting mortality in patients suffering from prolonged critical illness: an assessment of four severity-of-illness measuresS S Carson
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
Chest 120:928-33. 2001Investigators have been using severity-of-illness indexes such as APACHE II (acute physiology and chronic health evaluation score II) to describe patients with prolonged critical illness...
- APACHE II scoring system is superior in the prediction of the outcome in critically ill patients with perforative peritonitisSamir Delibegovic
Department of Surgery, University Clinic Center Tuzla, University of Tuzla, Bosnia and Herzegovina
Med Arh 65:82-5. 2011..This study was undertaken to evaluate APACHE II, SAPS I, Sepsis score, MOF, TISS-28 and MPI scoring systems in prediction of the outcome in patients with ..
- Evidence-based clinical practice guidelines for acute pancreatitis: proposalsToshihiko Mayumi
Department of Emergency Medicine and Intensive Care, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8560, Japan
J Hepatobiliary Pancreat Surg 9:413-22. 2002..To provide a framework for clinicians to manage acute pancreatitis, evidence-based guidelines have been developed by the Japanese Society of Abdominal Emergency Medicine...
- Comparison of Ranson, APACHE II and APACHE III scoring systems in acute pancreatitisConstantinos Chatzicostas
Department of Gastroenterology, University Hospital of Heraklion, Crete, Greece
Pancreas 25:331-5. 2002..Acute pancreatitis runs an unpredictable course. The early prediction of the severity of an acute attack has important implications for management and timely intervention...
- APACHE II and SAPS II are poorly calibrated in a Hong Kong intensive care unitI K Tan
Intensive Care Unit, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong SAR, People s Republic of China
Ann Acad Med Singapore 27:318-22. 1998This study seeks to determine if the Acute Physiology and Chronic Health Evaluation II (APACHE II) and the new Simplified Acute Physiology Score (SAPS II) model predictions are well calibrated in our adult Intensive Care Unit (ICU) ..
- Survival and outcome prediction using the Apache III and the out-of-hospital cardiac arrest (OHCA) score in patients treated in the intensive care unit (ICU) following out-of-hospital, in-hospital or ICU cardiac arrestM B Skrifvars
Intensive Care Unit, Liverpool Hospital, Sydney, Australia
Resuscitation 83:728-33. 2012..We investigated survival, factors associated with survival and the correlation and accuracy of general and specific scoring systems, including the Apache III score and the OHCA score in OHCA, IHCA and ICUCA patients.
- Predicting persistent Organ Failure early in Acute PancreatitisGeorgios I Papachristou; Fiscal Year: 2013..C-reactive protein) and 7 scoring systems (Ranson's, acute physiology and chronic health examination-II or APACHE-II, Glasgow, systemic inflammatory response syndrome, bedside index for severity in acute pancreatitis, Panc 3, ..
- The MIND USA StudyE Wesley Ely; Fiscal Year: 2012..to detect the effect of antipsychotics in 4 important subgroups including age >65 years, severity of illness (APACHE II >25), severe sepsis at enrollment, and medical vs...
- OpenLIS: The Development of a Clinical Laboratory Information System Using the OpROGER ALLAN HUBBARD; Fiscal Year: 2010..The Linux operating system, Apache web server, Firefox web browser, MySQL database are just some examples of such successes...
- Mechanisms and Population Genomics of Pneumococcal Antigenic DiversityMarc Lipsitch; Fiscal Year: 2013..We will perform whole genome sequencing of 800 pneumococcal isolates from a defined population (Navajo and Apache in the US Southwest) and apply the measures defined in Aim 1 to assess the evidence that each gene in the genome ..
- Plasma Protein Biomarker-Based Diagnostics Of Outcome In Sepsis and CAPSTEPHEN FRANCIS KINGSMORE; Fiscal Year: 2010..The biomarker panel will be compared with prognostic indices, such as metabolic endpoints and APACHE II score...
- Investigation of Cloud Computing to Support Data-Parallel Health ResearchGeoffrey C Fox; Fiscal Year: 2010..Example technologies include Microsoft Dryad and Apache Hadoop...
- Impact of PCV on disease and colonization among Native American communitiesKATHERINE LOUISE O'BRIEN; Fiscal Year: 2013..Within the United States some Native American groups, like the Navajo and the White Mountain Apache tribes, suffer from pneumococcal disease much more often than people in the general US population...
- PARP inhibitor therapy for septic shockAndrew Salzman; Fiscal Year: 2004..Secondary clinical endpoints will be reductions in 1) 28-day all cause mortality, 2) duration of ICU stay, 3) APACHE II index...
- BRIDGE TO THE BACCALAUREATE PROGRAM AT NEW MEXICO STATE UNIVERSITYBarbara A Lyons; Fiscal Year: 2013..These institutions enroll 5,414 AI students from the Din[unreadable] (Navajo) Nation, the Jicarilla Apache Nation, and eight Pueblos in New Mexico...
- Bridging Arizona Native American Students to Bachelor DegreesJANI CHERI INGRAM; Fiscal Year: 2013..is ideal since Flagstaff is considered a border town for the Navajo and Hopi Nations and near the White River Apache and Hualapai Nations...
- DELIRIUM IN PERSONS WITH DEMENTIADonna Fick; Fiscal Year: 2007..Katz ADL Scale, Lawton Instrumental Activities of Daily Living Scale (IADL), Charlson Co-morbidity Index, Apache II, the Clinical Dementia Rating scale (CDR), a family semi-structured interview form, and a Modified Blessed ..
- PROPHOLAXIS OF H. INFLUENZAE AND OTHER INFECTIONSMathuram Santosham; Fiscal Year: 1991..We will also compare the ability of Apache and Caucasians of various ages to make an antibody response to bacterial polysaccharide vaccines and search for ..
- Optimizing Risk-Adjustment for Measuring ICU QualityLaurent Glance; Fiscal Year: 2002..likely that ICU scoring systems will behave in the same manner; Specific Aim #1 will examine this hypothesis for APACHE 11 (Acute Physiology and Chronic Health Evaluation), SAPS 11 (Simplified Acute Physiology Score) and MPM II (..
- PHYSIOLOGIC OUTCOMES OF POSITIONING IN ACUTE HEAD TRAUMAJacqueline Sullivan; Fiscal Year: 2000..Injury Severity SCores, (ISS) and Apache III Scores are treated as covariates in this study...
- IMPROVING OUTCOMES IN MECHANICALLY VENTILATED PATIENTSLeslie Hoffman; Fiscal Year: 2003..capillary wedge pressure estimated non-invasively [ePCWP], acute physiology and chronic health evaluation [APACHE] III scores; 4) information needs (Patient/Family Information Needs Scale); 5) ICU resource consumption (ratio of ..
- Post-acute Care and Functional Recovery after HospitalizationSusan Hardy; Fiscal Year: 2009..This future index, like an APACHE score, could support prognostic and ultimately treatment guidelines for care of medically complex, recently ..
- PLANNING GRANT--DIABETES/NEPHROPATHY IN APACHE INDIANSW Walker; Fiscal Year: 1991..The planning effort for which support is requested will be focused upon a study of the White Mountain Apache reservation...
- METHODOLOGIC STUDIES ON APACHE IIIWILLIAM KNAUS; Fiscal Year: 1991..This project will extend the development and application of the APACHE (Acute Physiology and Chronic Health Evaluation) severity of illness classification system to the analysis and ..
- Assessing and Treating Symptoms of Dying ICU PatientsKathleen Puntillo; Fiscal Year: 2006..Patient illness acuity levels will be calculated per APACHE II, and nurse-patient staffing ratios, hospital site, and patient's DNR status will be recorded...
- GENE LINKAGE STUDY OF IMMUNODEFICIENCY IN NAVAJO INDIANSMorton Cowan; Fiscal Year: 2001..Immunodeficiency Disease (SCID) is found with increased incidence among Athabascan-speaking (A-SCID), Navajo, Apache, and Dine' Native Americans. Cowan and his colleagues have recently mapped the A-SCID gene to a 2...
- The Effect of Patient Volume on Outcome in the ICUJeremy Kahn; Fiscal Year: 2006..To test this hypothesis, the APACHE III database will be used to compare risk-adjusted mortality and ICU length of stay across participating ICUs...
- PATHWAYS--FULL SCALE STUDYJune Stevens; Fiscal Year: 2000..forty schools from six American Indian nations are involved: Pima/Maricopa, Tohono O'odham, Navajo, White Mountain Apache, Oglala Lakota, and Sicangu Lakota...
- PATHWAYS--PREVENTION OF OBESITY AMONG NAVAJO YOUTHSally Davis; Fiscal Year: 2000..six American Indian nations are involved: Gila River tribal preference) Tohono O'odham, Navajo, White Mountain Apache, Oglala lakota, and Sicangu Lakota...
- PATHWAYS--FULL SCALE STUDYBenjamin Caballero; Fiscal Year: 2000..forty schools from six American Indian nations are involved: Pima/Maricopa, Tohono O'odham, Navajo, White Mountain Apache, Oglala Lakota, and Sicangu Lakota...
- Open-source Science Education Software on the WebPaul Wright; Fiscal Year: 2001..of the most successful and fastest growing software is open-source (such as the Linux operating system, and the Apache web server)...
- SEARCH for Diabetes in Youth 2: Colorado CenterDana Dabelea; Fiscal Year: 2009..These include: the Navajo Nation, the White Mountain Apache Reservation and the Gila River Pima Reservation...
- Impact of Psychoactive Drugs on Delirium in ICU PatientsMargaret Pisani; Fiscal Year: 2008..Ultimately, we hope this work will lead to the development of specific interventions in ICU drug therapy vital to the care of more than four million critically ill patients in the United States. ..
- Are Volume Standards Accurate Measures of Quality?Laurent Glance; Fiscal Year: 2005..abstract_text> ..
- Feasibility of Measuring Sleep in a Critical Care EnvironmentMargaret A Pisani; Fiscal Year: 2010....
- PREDICTIVE RISK MODEL IN ACUTE ISCHEMIC STROKEKaren Johnston; Fiscal Year: 2004..This will be valuable to patients with stroke, providers, payers and developers of new drug therapies. ..
- Identification of Green Tea Polyphenol-Targeted GenesStephen Hsu; Fiscal Year: 2004..Data generated from this proposal may reveal novel drug targets for treatment of head and neck cancer. ..
- TRIAL OF ACTIVITY FOR ADOLESCENT GIRLS (TAAG)Timothy Lohman; Fiscal Year: 2005..The team brings expertise in PA program design, PA and fitness assessment, formative assessment, behavior theory and curriculum development, intervention delivery, process evaluation, and data management. ..
- RISK FACTORS & BIOMARKERS OF OX STRESS IN GRAFT FAILUREJason Christie; Fiscal Year: 2004..abstract_text> ..
- PERIPHERAL CANNABINOIDS AND NEUROGENIC INFLAMMATIONKenneth Hargreaves; Fiscal Year: 2002..This knowledge base may provide a rationale for developing peripherally-selective cannabinoid analgesics with minimal CNS-mediated side-effect liability. ..
- The MIND ICU StudyE Wesley Ely; Fiscal Year: 2010....
- Hospital and Community Acquired Acute Renal FailureGlenn Chertow; Fiscal Year: 2006..This study will efficiently inform the Nephrology community by providing a foundation of fundamental information (ARF definitions, incidence, consequences and costs) upon which a clinical trials network can be built. ..
- TRIAL OF FAS PREVENTION IN AMERICAN INDIAN COMMUNITIESPhilip May; Fiscal Year: 2001..Furthermore, prevention protocols, research techniques and methods, will test the recommendations of the IOM report and should also be applicable to non-Indian communities as well. ..
- Project PROTECT IIGordon Bernard; Fiscal Year: 2003..abstract_text> ..
- Cannabinoid Modulation of Capsaicin-Sensitive NociceptorsKenneth M Hargreaves; Fiscal Year: 2010..Second, identification of cannabinoid modulation of pain via TRPchannels provides a rationale for a novel class of analgesics that are devoid of classical cannabinoid side effects. ..
- Neuropeptide Y Regulation of Peripheral Human Nociceptors and PainKenneth Hargreaves; Fiscal Year: 2007..Moreover, our study population in South Texas permits secondary analyses of a potentially underserved population (predominantly Hispanic) that is at risk for caries-induced pulpal necrosis and pain. [unreadable] [unreadable]..
- Cognitive Impairment in the ICU: Evaluation and OutcomesE Ely; Fiscal Year: 2005..Along with the candidate's record of publications and achievement, he will have rich academic surroundings, excellent mentors and strong institutional commitment to ensure that he achieve these goals. ..
- Glucose Regulation in Acute Stroke Patients (GRASP)Karen Johnston; Fiscal Year: 2007....
- Immuno-modulatory Effects of Parenteral Nutrition After Intestinal FailureStephen Benedict; Fiscal Year: 2007..The data obtained will position the research team to develop more mechanistically in-depth RO1 proposals that investigate human patients and a murine PN animal model. [unreadable] [unreadable] [unreadable]..
- Exploring Measurement of Palliative Care Quality in ICUsJudith Nelson; Fiscal Year: 2008..N/A [unreadable] [unreadable] [unreadable]..
- Galectin-3 and Expression of the Asthma PhenotypeCraig Lilly; Fiscal Year: 2008..These studies will provide new insights into the complex role of lectins and their ligands in allergic diseases. ..
- Biomarker Profiles in the Diagnosis/Prognosis of ARDSLorraine Ware; Fiscal Year: 2008..unreadable] [unreadable]..
- Prostaglandins, Leukotrienes, and Innate ImmunityCraig Lilly; Fiscal Year: 2008..unreadable] [unreadable]..
- Sedation Effects in Mechanically Ventilated PatientsMary Jo Grap; Fiscal Year: 2009..abstract_text> ..
- Mouse model for sepsisH Warren; Fiscal Year: 2009..abstract_text> ..
- Depressive Symptoms, Aging, Disability and Health OutcomesKenneth Covinsky; Fiscal Year: 2009....
- The Effect of Hypertonic Resuscitation for Blunt TraumaEileen Bulger; Fiscal Year: 2005..abstract_text> ..
- Long Term Outcomes in ICU Patients: Delirium & Apolipoprotein ESheila Alexander; Fiscal Year: 2009..This would likely lead to decreased time in the ICU and hospital. ..
- Hypertonic Modulation of Inflammation following InjuryEileen M Bulger; Fiscal Year: 2010..The results of these studies will provide valuable information to determine the ultimate therapeutic use of the resuscitation strategy. ..