computer aided design

Summary

Summary: The use of computers for designing and/or manufacturing of anything, including drugs, surgical procedures, orthotics, and prosthetics.

Top Publications

  1. ncbi Fracture load of composite resin and feldspathic all-ceramic CAD/CAM crowns
    Ahmed Attia
    Department of Conservative Dentistry and Fixed Prosthodontics, Faculty of Dentistry, Mansoura University, Egypt
    J Prosthet Dent 95:117-23. 2006
  2. ncbi Computer aided design of large-format prefabricated cranial plates
    David Dean
    Department of Neurological Surgery and the Research Institute, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Craniofac Surg 14:819-32. 2003
  3. ncbi Concepts to automate the theoretical design of effective antisense oligonucleotides
    R K Far
    , , Ratzeburger Allee 160, , Germany
    Bioinformatics 17:1058-61. 2001
  4. ncbi Factors influencing blood flow patterns in the human right coronary artery
    J G Myers
    Department of Mechanical and Industrial Engineering, University of Toronto, Ontario, Canada
    Ann Biomed Eng 29:109-20. 2001
  5. ncbi PHASE: a new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results
    Steven L Dixon
    Schrodinger, Inc, 120 W 45th St, 29th Floor, New York, NY 10036, USA
    J Comput Aided Mol Des 20:647-71. 2006
  6. ncbi Finite-element analysis on closing-opening correction osteotomy for angular kyphosis of osteoporotic vertebral fractures
    Taizo Hato
    Department of Orthopaedic Surgery, Kanazawa University, 13 1 Takaramachi, Kanazawa, Japan
    J Orthop Sci 12:354-60. 2007
  7. ncbi Evaluation of different miniplates in fixation of fractured human mandible with the finite element method
    Hasan Husnu Korkmaz
    Civil Engineering Department, Engineering and Architecture Faculty, Selcuk University, Konya, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:e1-13. 2007
  8. ncbi Genetic design: rising above the sequence
    Jonathan A Goler
    Synthetic Biology Engineering Research Center, University of California Berkeley, CA 94720, USA
    Trends Biotechnol 26:538-44. 2008
  9. ncbi Design of a genome-wide siRNA library using an artificial neural network
    Dieter Huesken
    Novartis Institutes for BioMedical Research, Genome and Proteome Sciences, CH 4002 Basel, Switzerland
    Nat Biotechnol 23:995-1001. 2005
  10. ncbi 3-dimensional printing of models to create custom-made devices for coil embolization of an anastomotic leak after aortic arch replacement
    Ralf Sodian
    Department of Cardiac Surgery, Ludwig Maximilians University, Munich, Germany
    Ann Thorac Surg 88:974-8. 2009

Detail Information

Publications285 found, 100 shown here

  1. ncbi Fracture load of composite resin and feldspathic all-ceramic CAD/CAM crowns
    Ahmed Attia
    Department of Conservative Dentistry and Fixed Prosthodontics, Faculty of Dentistry, Mansoura University, Egypt
    J Prosthet Dent 95:117-23. 2006
    ....
  2. ncbi Computer aided design of large-format prefabricated cranial plates
    David Dean
    Department of Neurological Surgery and the Research Institute, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Craniofac Surg 14:819-32. 2003
    ..Therefore, the authors conclude that their new production method provides a better result with less expense than current methods for preoperative or intraoperative fabrication of large-format cranioplasties...
  3. ncbi Concepts to automate the theoretical design of effective antisense oligonucleotides
    R K Far
    , , Ratzeburger Allee 160, , Germany
    Bioinformatics 17:1058-61. 2001
    ..In the following we describe how individual steps of the theoretical design of asON may be automated by establishing and implementing suitable algorithms...
  4. ncbi Factors influencing blood flow patterns in the human right coronary artery
    J G Myers
    Department of Mechanical and Industrial Engineering, University of Toronto, Ontario, Canada
    Ann Biomed Eng 29:109-20. 2001
    ....
  5. ncbi PHASE: a new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results
    Steven L Dixon
    Schrodinger, Inc, 120 W 45th St, 29th Floor, New York, NY 10036, USA
    J Comput Aided Mol Des 20:647-71. 2006
    ....
  6. ncbi Finite-element analysis on closing-opening correction osteotomy for angular kyphosis of osteoporotic vertebral fractures
    Taizo Hato
    Department of Orthopaedic Surgery, Kanazawa University, 13 1 Takaramachi, Kanazawa, Japan
    J Orthop Sci 12:354-60. 2007
    ..Finite-element (FE) analysis was performed to estimate the biomechanical stress with both osteoporotic grades and corrective kyphotic angles during COC osteotomy for osteoporotic angular kyphosis...
  7. ncbi Evaluation of different miniplates in fixation of fractured human mandible with the finite element method
    Hasan Husnu Korkmaz
    Civil Engineering Department, Engineering and Architecture Faculty, Selcuk University, Konya, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:e1-13. 2007
    ..The results obtained from this study offer the choice of a particular plate size, thickness, design, or configuration for application and thus provide information for clinical use...
  8. ncbi Genetic design: rising above the sequence
    Jonathan A Goler
    Synthetic Biology Engineering Research Center, University of California Berkeley, CA 94720, USA
    Trends Biotechnol 26:538-44. 2008
    ..Specialized computer languages or a general purpose XCell Description Language are promising avenues to build abstraction hierarchies for synthetic biology...
  9. ncbi Design of a genome-wide siRNA library using an artificial neural network
    Dieter Huesken
    Novartis Institutes for BioMedical Research, Genome and Proteome Sciences, CH 4002 Basel, Switzerland
    Nat Biotechnol 23:995-1001. 2005
    ..When this collection of 50,000 siRNAs was used to identify genes involved in the cellular response to hypoxia, two of the most potent hits were the key hypoxia transcription factors HIF1A and ARNT...
  10. ncbi 3-dimensional printing of models to create custom-made devices for coil embolization of an anastomotic leak after aortic arch replacement
    Ralf Sodian
    Department of Cardiac Surgery, Ludwig Maximilians University, Munich, Germany
    Ann Thorac Surg 88:974-8. 2009
    ....
  11. ncbi Design of tissue engineering scaffolds as delivery devices for mechanical and mechanically modulated signals
    Eric J Anderson
    Department of Mechanical and Aerospace Engineering, Case School of Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Tissue Eng 13:2525-38. 2007
    ....
  12. ncbi A review of protein-small molecule docking methods
    R D Taylor
    Department of Chemistry, University of Southampton, Highfield, UK
    J Comput Aided Mol Des 16:151-66. 2002
    ..An overview of current docking techniques is presented with a description of applications including single docking experiments and the virtual screening of databases...
  13. ncbi Protein flexibility and computer-aided drug design
    Chung F Wong
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093 0365, USA
    Annu Rev Pharmacol Toxicol 43:31-45. 2003
    ....
  14. ncbi Putting engineering back into protein engineering: bioinformatic approaches to catalyst design
    Claes Gustafsson
    DNA 2 0, Inc, 1455 Adams Drive, Menlo Park, CA 94025, USA
    Curr Opin Biotechnol 14:366-70. 2003
    ..This provides an alternative approach to expensive assays or unreliable high-throughput surrogate screens...
  15. ncbi [Rapid prototyping in planning reconstructive surgery of the head and neck. Review and evaluation of indications in clinical use]
    J S Bill
    Klinik und Poliklinik für Mund Kiefer Gesichtschirurgie, Julius Maximilians Universitat Wurzburg
    Mund Kiefer Gesichtschir 8:135-53. 2004
    ..The aim was to define the indications for use of rapid prototyping models based on data of patients treated with this technique...
  16. ncbi Selecting signature oligonucleotides to identify organisms using DNA arrays
    Lars Kaderali
    Center for Applied Computer Sciences Cologne ZAIK, University of Cologne, Weyertal 80, 50931 Koln, Germany
    Bioinformatics 18:1340-9. 2002
    ..Furthermore, all probes on the array must hybridize to their intended targets under the same reaction conditions, most importantly at the temperature T at which the experiment is conducted...
  17. pmc The kinetics of analyte capture on nanoscale sensors
    J E Solomon
    Condensed Matter Physics, California Institute of Technology, Pasadena, California, USA
    Biophys J 90:1842-52. 2006
    ..For the two modalities studied, we find that detection of specific biomolecules down to concentration levels of 1 nM or less appear to be quite feasible for the device configurations studied...
  18. ncbi Distant energy transfer for artificial human implants
    Michael P Theodoridis
    Department of Electronic, Electrical, and Computer Engineering, University of Birmingham, UK
    IEEE Trans Biomed Eng 52:1931-8. 2005
    ..The correctness of the analysis of this later design procedure has been verified by experimental results. Measurements with a human tissue simulant also show little deviation from the predictions...
  19. ncbi A probe for organ impedance measurement
    Kevin S Paulson
    Radiocommunications Research Unit of Rutherford Appleton Laboratory, Chilton, Didcot, OXON OX10 0QX, UK
    IEEE Trans Biomed Eng 51:1838-44. 2004
    ..A probe and driving hardware have been constructed and experimental results are provided showing the accuracy of admittance measurements at 50 and 640 KHz...
  20. ncbi Combination of optimized transmit arrays and some receive array reconstruction methods can yield homogeneous images at very high frequencies
    Christopher M Collins
    Center for NMR Research, Penn State College of Medicine, Hershey, PA 17033, USA
    Magn Reson Med 54:1327-32. 2005
    ....
  21. ncbi Investigation of the scaling rules determining the performance of film bulk acoustic resonators operating as mass sensors
    Jan Weber
    Siemens AG, Corporate Technology, Munchen, Germany
    IEEE Trans Ultrason Ferroelectr Freq Control 54:405-12. 2007
    ..It was found that increasing the frequency leads to a principally improved performance of these devices. Problems arising for the horizontal as well as the vertical dimension and structure are investigated...
  22. ncbi Influence of probe size on the measurement accuracy of non-uniform ELF magnetic fields
    Oriano Bottauscio
    Istituto Elettrotecnico Nazionale Galileo Ferraris IEN Strada delle Cacce 91, 10135 Torino, Italy
    Radiat Prot Dosimetry 111:369-72. 2004
    ....
  23. ncbi Versatile coil design and positioning of transverse-field RF surface coils for clinical 1.5-T MRI applications
    M Alfonsetti
    INFM and Dipartimento di Scienze e Tecnologie Biomediche, Universita dell Aquila, Via Vetoio, 67100 L Aquila, Italy
    MAGMA 18:69-75. 2005
    ..Transverse RF coil design should be useful for clinical MRS studies and also for parallel imaging techniques where versatile RF coils disposed along arbitrary directions are required...
  24. ncbi Basic considerations on the impact of the coil array on the performance of Transmit SENSE
    U Katscher
    Philips Research Laboratories, Sector Technical Systems, Roentgenstrasse 24 26, D 22335, Hamburg, Germany
    MAGMA 18:81-8. 2005
    ..The problem of an ill-conditioned matrix inversion does not seem to play a major role in Transmit SENSE. Consequently, the freedom in designing coil arrays seems to be much larger in Transmit SENSE than in SENSE in the receive mode...
  25. ncbi Theoretical foundation for real-time prostate localization using an inductively coupled transmitter and a superconducting quantum interference device (SQUID) magnetometer system
    John E McGary
    Department of Radiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Appl Clin Med Phys 5:29-45. 2004
    ..We present the theoretical foundation for designing a real-time, 3D prostate localization system including the associated physical parameters and demonstrate the feasibility and physical limitations for such a system...
  26. ncbi Considerations in the design and sensitivity optimization of the micro tactile sensor
    Yoshinobu Murayama
    College of Engineering, Nihon University, Koriyama, Fukushima 963 8642, Japan
    IEEE Trans Ultrason Ferroelectr Freq Control 52:434-8. 2005
    ..And, from the consideration of theory and experimental data, a sensitivity coefficient was proposed and found to be useful...
  27. ncbi Selecting algorithms, sensors, and linear bases for optimum spectral recovery of skylight
    Miguel A López-Alvarez
    Departamento de Optica, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain
    J Opt Soc Am A Opt Image Sci Vis 24:942-56. 2007
    ..We show how all these parameters play an important role in the practical design of a real multispectral system and how to obtain several relevant conclusions from simulating the behavior of sensors in the presence of noise...
  28. ncbi Elastic, piezoelectric, and dielectric characterization of modified BiScO3-PbTiO3 ceramics
    Shujun Zhang
    Material Research Institute, Pennsylvania State University, University Park, PA 16802, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:2131-9. 2005
    ..36BiScO3-0.64PbTiO3 and PZT5A ceramics...
  29. ncbi Radial vibration of the composite ultrasonic transducer of piezoelectric and metal rings
    Shuyu Lin
    IEEE Trans Ultrason Ferroelectr Freq Control 54:1276-80. 2007
    ..Experiments show that the measured resonance frequencies are in a good agreement with the theoretical results...
  30. ncbi Design and performance issues of RF coils utilized in ultra high field MRI: experimental and numerical evaluations
    Tamer S Ibrahim
    School of Electrical Engineering and Center for Bioengineering, University of Oklahoma, 202 W Boyd Street, Norman, OK 73071, USA
    IEEE Trans Biomed Eng 52:1278-84. 2005
    ..As such, depending on the application, the shorter coil could be effectively utilized...
  31. ncbi Thickness-twist edge modes in a semi-infinite piezoelectric plate of crystals with 6mm symmetry
    Jiashi Yang
    IEEE Trans Ultrason Ferroelectr Freq Control 54:220-1. 2007
    ..This suggests the possibility of new thickness-twist plate edge mode resonators and acoustic wave sensors with certain advantages...
  32. ncbi Analysis of spectrally resolved thermoluminescence of LiF:Mg,Cu,P detectors by the surface fitting method using algorithm for unrestricted peak positions
    Ewa Mandowska
    Institute of Physics, JD University, ul Armii Krajowej 13 15, Pl 42 200 Czestochowa, Poland
    Radiat Prot Dosimetry 119:89-92. 2006
    ..The spectra were analysed using two different variants of surface fitting--for restricted and unrestricted peak positions...
  33. ncbi Segmented crystalline scintillators: empirical and theoretical investigation of a high quantum efficiency EPID based on an initial engineering prototype CsI(TI) detector
    Amit Sawant
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48103, USA
    Med Phys 33:1053-66. 2006
    ....
  34. ncbi A KLM-circuit model of a multi-layer transducer for acoustic bladder volume measurements
    E J W Merks
    Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands
    Ultrasonics 44:e705-10. 2006
    ..It also allowed for further optimization with respect to electrical matching and transmit waveform. Additionally, the model demonstrated the effect of mechanical loading of the PVDF-layer on the PZT transducer...
  35. ncbi An analytic model for the response of a CZT detector in diagnostic energy dispersive x-ray spectroscopy
    Robert J Leclair
    Department of Physics and Astronomy, Laurentian University, 935 Ramsey Lake Road, Sudbury, Ontario P3E 2C6, Canada
    Med Phys 33:1329-37. 2006
    ..The percent differences were 0.8% when corrections were applied and 25% for no corrections. The model can be used to correct diagnostic x-ray spectra measured with a CdZnTe detector...
  36. ncbi Analysing radio-frequency coil arrays in high-field magnetic resonance imaging by the combined field integral equation method
    Shumin Wang
    Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Phys Med Biol 51:3211-29. 2006
    ..0 T SENSE functional MRI. Numerical results show that the signal dropout and the average SNR are two major concerns in SENSE coil array design. A good design should be a balance of these two factors...
  37. pmc A time-space decomposition method for calculating the nearfield pressure generated by a pulsed circular piston
    James F Kelly
    Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 53:1150-9. 2006
    ....
  38. ncbi Performance optimization of plate-mode sensors with bi-layered structure
    Li Fan
    Laboratory of Modern Acoustics, Institute of Acoustics, Nanjing University, Nanjing 210093, PR China
    Ultrasonics 44:e917-21. 2006
    ....
  39. ncbi Noise level analysis in buffer rod geometries for ultrasonic sensors
    J Garcia-Alvarez
    Department of Electronic Engineering, Polytechnic University of Catalonia, Comte d Urgell, 187, SC08, EUETIB, 08036 Barcelona, Spain
    Ultrasonics 44:e1093-100. 2006
    ..Design aspects such as buffer rods length and radius, piezoceramic disk frequency and radius are discussed and their influence on noise level is shown. Finally, strategies for optimum geometry design of the ultrasonic sensor are given...
  40. ncbi Modelling radiation loads to detectors in a SNAP mission
    N V Mokhov
    Fermi National Accelerator Laboratory, MS 220, Batavia, IL 60510 0500, USA
    Radiat Prot Dosimetry 116:224-7. 2005
    ..The contribution of primary alpha particles is estimated. Predicted performance degradation for the photodetector for a four-year space mission is 40% and this can be reduced further by means of shielding optimisation...
  41. ncbi Experimental and MC determination of HPGe detector efficiency in the 40-2754 keV energy range for measuring point source geometry with the source-to-detector distance of 25 cm
    Pavel Dryak
    Czech Metrology Institute Inspectorate for Ionizing Radiation CMI, Radiova 1, CZ 102 00 Prague 10, Czech Republic
    Appl Radiat Isot 64:1346-9. 2006
    ..The model was validated by comparing calculated and experimental full energy peak efficiencies in the 40-2754 keV energy range, for point-source geometry with the source-to-detector distance of 25 cm...
  42. ncbi A compact permanent magnet array with a remote homogeneous field
    Andrew E Marble
    MRI Centre, Department of Physics, P O Box 4400, University of New Brunswick, Fredericton, NB, Canada E3B 5A3
    J Magn Reson 186:100-4. 2007
    ..Unlike other sweet spot magnets of this general type, our array has B(0) oriented parallel to its surface. This allows an ordinary surface coil to be used for unilateral measurements, giving the potential for dramatic SNR improvement...
  43. ncbi A novel, single-mode piezoceramic plate actuator for ultrasonic linear motors
    Oleksiy Vyshnevskyy
    Physik Instrumente GmbH and Co KG, auf der Roemerstrasse 1, D 76228 Karlsruhe, Germany
    IEEE Trans Ultrason Ferroelectr Freq Control 52:2047-53. 2005
    ..This paper describes this work and closes by describing the new ultrasonic translation stages based on this design...
  44. pmc Design and fabrication of broadband graded ultrasonic transducers with rectangular kerfs
    Hongkai Guo
    National Institutes of Health Transducer Resource Center and Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089 1451, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 52:2096-102. 2005
    ..A superior bandwidth of 92% was achieved by the graded transducer when compared to a bandwidth of 56% produced by the nondiced ceramic transducer at the expense of a reduced sensitivity...
  45. ncbi Generation and detection of guided waves using PZT wafer transducers
    Jeroen H Nieuwenhuis
    Institute of Sensor and Actuator Systems, Vienna University of Technology, Vienna, Austria
    IEEE Trans Ultrason Ferroelectr Freq Control 52:2103-11. 2005
    ..We show that the received signals for A0 and S0 modes have maxima near the frequencies predicted from the previously published point-force model...
  46. ncbi Variational principles for the equations of porous piezoelectric ceramics
    Gülay Altay
    Faculty of Enginering, Bogazici University, Bebek 34342, Istanbul, Turkey
    IEEE Trans Ultrason Ferroelectr Freq Control 52:2112-9. 2005
    ..Certain special cases and reciprocal variational principles are recorded, and they are shown to recover some of the earlier ones...
  47. ncbi A method of "weak resonance" for quality factor and coupling coefficient measurement in piezoelectrics
    Alex V Mezheritsky
    IEEE Trans Ultrason Ferroelectr Freq Control 52:2120-30. 2005
    ....
  48. ncbi Vibration of piezoelectric/elastic laminated trimorph ring transducer
    Jann Fang Lin
    IEEE Trans Ultrason Ferroelectr Freq Control 52:2146-52. 2005
    ..The resonance, antiresonance frequencies with corresponding mode shapes were verified by the measured impedance frequency responses. And, the design of maximized electromechanical coupling coefficients (EMCC) is proceeded...
  49. ncbi The excitation and detection of lamb waves with planar coil electromagnetic acoustic transducers
    Paul D Wilcox
    Department of Mechanical Engineering, University of Bristol, Bristol, BS8 1TR, UK
    IEEE Trans Ultrason Ferroelectr Freq Control 52:2370-83. 2005
    ..The model then is used to analyze the different effects that contribute to the overall Lamb wave modal sensitivity of an EMAT. The relationship between coil geometry and wavelength is examined...
  50. ncbi Sensitivity of a Lamb wave sensor with 2 microm AlN membrane
    R Duhamel
    FEMTO ST Institute, LPMO Department CNRS UMR 6174, 32, Besancon Cedex, France
    Ultrasonics 44:e893-7. 2006
    ....
  51. ncbi Dosimetric considerations on TEPC fluka-simulation and measurements
    S Rollet
    Austrian Research Centre Seibersdorf, A 2444 Seibersdorf, Austria
    Radiat Prot Dosimetry 110:833-7. 2004
    ..The agreement between the calculated results and the measurements carried out with different well-known sources is well demonstrated. Work is in progress in order to evaluate the response of the instrument in the cosmic ray environment...
  52. doi Method for nonlinear characterization of radio frequency coils made of high temperature superconducting material in view of magnetic resonance imaging applications
    Olivier Girard
    U2R2M UMR8081, University Paris Sud, CNRS, Orsay Cedex 91405, France
    Rev Sci Instrum 78:124703. 2007
    ..The method could be extended to assess the fundamental properties of the nonlinear material (e.g., the London penetration depth or the critical current density) by including any pertinent model...
  53. ncbi A three si detector system for personnel neutron dosimetry developed by means of Monte Carlo simulation calculations
    R Schutz
    Gesellschaft fur Schwerionenforschung, Planckstrasse 1, D 64291 Darmstadt, Germany
    Radiat Prot Dosimetry 104:17-26. 2003
    ..The detector system should be able to measure a dose range down to 10 microSv depending on the neutron energy...
  54. ncbi Mathematical model of a double-coil inductive transducer for measuring electrical conductivity
    Jozef Kusmierz
    Department of Electrical and Computer Engineering, Kielce University of Technology, Al 1000 lecia P P 7, PL 25 314, Kielce, Poland
    Rev Sci Instrum 78:084704. 2007
    ..Then, the conductivity measurements of a sample made of brass have been carried out. The obtained experimental results confirm the high accuracy of the theoretical analysis...
  55. ncbi Dynamic response analysis of pyroelectric sensitive element for thermal imaging
    Yung Sup Yoon
    IEEE Trans Ultrason Ferroelectr Freq Control 50:461-5. 2003
    ..5), and, in the region of intermediate frequencies, the voltage responsivity is independent of frequency...
  56. ncbi Analysis of temperature compensation in a plate thickness mode bulk acoustic wave resonator
    Huan Xue
    Department of Mechanics, School of Civil Engineering and Mechanics, Huazhong University of Science and Technology, Wuhan 430074, China
    IEEE Trans Ultrason Ferroelectr Freq Control 54:1826-33. 2007
    ..It is shown that, with a proper design of the compensation layer, temperature sensitivity of the resonator can be reduced or made zero...
  57. ncbi Sensitivity dependences on side length and aspect ratio of a diaphragm in a glass-based guided-wave optical pressure sensor
    Hiroyuki Nikkuni
    Graduate School of Science and Technology, Niigata University, Niigata, Japan
    Opt Express 16:15024-32. 2008
    ..In this study, sensitivity dependences on side length and aspect ratio of the diaphragm were experimentally examined. The obtained experimental results strongly supported the theoretical predictions...
  58. ncbi Bandwidth enhancement of electro-optic field sensing using photonic down-mixing with harmonic sidebands
    Dong Joon Lee
    Department of Electrical Engineering and Computer Science, Center for Ultrafast Optical Science, University of Michigan, Ann Arbor, Michigan 48109 2099, USA
    Opt Express 16:14771-9. 2008
    ..Transverse near-field distributions from high frequency patch antennas are extracted using both second- and third-order-harmonic sidebands...
  59. ncbi Optimizing the beam pattern of a forward-viewing ring-annular ultrasound array for intravascular imaging
    Yao Wang
    Biomedical Engineering Department, University of Michigan, Ann Arbor, MI, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 49:1652-64. 2002
    ..Simulation results demonstrate this design can achieve side-lobes under -40 dB for on-axis situations and under -30 dB for steering to the edge of a 80 degrees cone...
  60. ncbi The effect of a distributed mass loading on the frequency response of a MEMS mesh resonator
    M J Bartkovsky
    Dept of Chem Eng, Carnegie Mellon Univ, Pittsburgh, PA 15213, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1862-5. 2006
    ..We use a finite element model to demonstrate how a distributed mass loading affect the frequency responses of our MEMS structures...
  61. ncbi Oximetry considerations in the small source detector separation limit
    Brian Winey
    Dept of Phys and Astron, Rochester Univ, Rochester, NY 14642, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1941-3. 2006
    ..The study demonstrates that visible wavelengths are more than two orders of magnitude more sensitive to changes in hemoglobin saturation when small source detector fiber separations are used for oximetry measurements...
  62. ncbi Mass and position determination of attached particles on cantilever based mass sensors
    S Dohn
    MIC, Department of Micro and Nanotechnology, NanoDTU, Technical University of Denmark, Building 345E, DK 2800 Lyngby, Denmark
    Rev Sci Instrum 78:103303. 2007
    ..The bead mass and position calculated from the measured resonant frequencies are in good agreement with the expected mass and the position measured...
  63. ncbi Numerical study of the SNR and SAR of MRI coil arrays
    R Rojas
    Electrical Engineering Department, Universidad, Autónoma Metropolitana Iztapalapa, Mexico, DF 09340, Mexico
    Conf Proc IEEE Eng Med Biol Soc 2007:1196-9. 2007
    ..Results showed a good agreement with those reported in the literature. The visualization of the electromagnetic fields allows us to study the behavior of a particular coil array configuration...
  64. ncbi A novel pyroelectric method of determining ultrasonic transducer output power: device concept, modeling, and preliminary studies
    Bajram Zeqiri
    Quality of Life Division, National Physical Laboratory, Hampton Road, Teddington, TW11 OLW, UK
    IEEE Trans Ultrason Ferroelectr Freq Control 54:2318-30. 2007
    ..The potential of the new method as a simple, rapid means of providing traceable ultrasonic power measurements is outlined...
  65. ncbi Improving the sensitivity of SPR sensors based on gratings by double-dips method (DDM)
    Debin Cai
    Department of Physics, Anhui Key Laboratory of Optoelectronic Science and Technology, University of Science andTechnology of China, Hefei, Anhui 230026, PR China
    Opt Express 16:14597-602. 2008
    ..In different performance comparisons, DDM has roundly better performances than other methods. Moreover, when the grating profile errs from rectangle, DDM still works well...
  66. ncbi A dynamic vector model of microstrip RF resonators for high-field MR imaging
    A Vukovic
    George Green Institute for Electromagnetics Research, School of Electrical and Electronic Engineering, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
    IEEE Trans Med Imaging 27:766-74. 2008
    ..Finally, a variational approach is used to assess the impact of the intermodal coupling for the case of small perturbations in the shape and the position of the cylindrical phantom...
  67. ncbi Application of a Ge semi-conductor detector to whole-body counter
    S Kinase
    Japan Atomic Energy Research Institute, 2 4 Shirane, Shirakata, Tokai mura, Ibaraki 319 1195, Japan
    Radiat Prot Dosimetry 105:467-72. 2003
    ..This simulation provides a method to determine an optimum arrangement of detectors in a whole-body counter, offering a uniform response to various 137Cs distributions in a human body...
  68. ncbi Modeling the instantaneous dose rate dependence of radiation diode detectors
    Jie Shi
    Sun Nuclear Corporation, Melbourne, Florida 32940, USA
    Med Phys 30:2509-19. 2003
    ..A diode could have very small r dependence due to large R-G center concentration, generated by heavy platinum doping or radiation accumulated dose. Experimental data are compared with theory...
  69. ncbi Quartz crystal microbalance based on torsional piezoelectric resonators
    W Bücking
    Institute of Physical Chemistry, Clausthal University of Technology, Arnold Sommerfeld Strasse 4, D 38678 Clausthal Zellerfeld, Germany
    Rev Sci Instrum 78:074903. 2007
    ..Details of the geometry matter if the viscoelastic properties of the sample are of interest...
  70. ncbi The filter/moderator arrangement-optimisation for the boron-neutron capture therapy (BNCT)
    G Tracz
    The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, ul Radzikowskiego 152, 31 342 Krakow, Poland
    Radiat Prot Dosimetry 110:827-31. 2004
    ..It yields one order of magnitude lower gamma radiation dose than the maximum allowed dose in such a type of therapeutic facility. The MCNP code has been used for the computations...
  71. ncbi Development of a fast neutron spectrometer composed of silicon-SSD and position-sensitive proportional counters
    T Matsumoto
    National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology, Tsukuba, 305 8568, Japan
    Radiat Prot Dosimetry 110:223-6. 2004
    ..The characteristics of the spectrometer were evaluated with a monoenergetic neutron beam. The best energy resolution was 1.8% for 5.0 MeV neutrons...
  72. ncbi Development of a portable high-energy neutron spectrometer
    Thomas D McLean
    Los Alamos National Laboratory, HSR 4, PO Box 1663, MS J 573, Los Alamos, NM 87545, USA
    Radiat Prot Dosimetry 110:219-22. 2004
    ..Preliminary experimental data are presented, and the importance of validating MCNPX-generated response functions is discussed. A brief discussion on future work follows...
  73. ncbi Characteristics of the simulated workplace neutron fields using a 252Cf source surrounded with cylindrical moderators
    N Tsujimura
    Radiation Protection Division, Japan Nuclear Cycle Development Institute, 4 33, Tokai, Ibaraki 319 1194, Japan
    Radiat Prot Dosimetry 110:117-21. 2004
    ..These fields can provide the realistic neutron spectra similar to those encountered around the glove-boxes of the fabrication process of MOX (PuO2-UO2 mixed oxide) fuel...
  74. ncbi Experimental and simulational study of the operation conditions for a high transmission mass filter
    A I Ayesh
    The MacDiarmid Institute of Advanced Materials and Nanotechnology, University of Canterbury, Christchurch 8020, New Zealand
    Rev Sci Instrum 78:053906. 2007
    ..The study shows that this mass filter is suitable for technological applications because of its high transmission and wide mass range...
  75. ncbi X-ray scatter data for flat-panel detector CT
    Yiannis Kyriakou
    Institute of Medical Physics, University of Erlangen Nuremberg, Henkestrasse 91, 91052 Erlangen, Germany
    Phys Med 23:3-15. 2007
    ..Single scatter appears to determine the distribution and magnitude of the total-scatter intensity at the detector...
  76. ncbi Reducing inter-element acoustic crosstalk in capacitive micromachined ultrasound transducers
    Shiwei Zhou
    Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22901, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 54:1217-28. 2007
    ..5 dB was achieved. This method also can be combined with other structure-modification based crosstalk reduction approaches...
  77. ncbi Parametric linear modeling of circular cMUT membranes in vacuum
    Hayrettin Koymen
    Department, Bilkent University, Ankara, 06800 Turkey
    IEEE Trans Ultrason Ferroelectr Freq Control 54:1229-39. 2007
    ..Equivalent circuit model parameters can be found from material properties and membrane dimensions without a need for finite element simulation...
  78. ncbi Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: an experimental and computational study at 337 nm
    Thanassis Papaioannou
    Biophotonics Research and Technology Development, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Appl Opt 43:2846-60. 2004
    ..The findings can be applied toward optimization of fiber-optic probe designs for quantitative optical spectroscopy of turbid media including biological tissues...
  79. ncbi [Research progress of dental machinable materials]
    Xiao Zhou Liu
    Research Center of Engineering and Technology for Computerized Dentistry, Ministry of Health, Peking University School and Hospital of Stomatology, Beijing, China
    Beijing Da Xue Xue Bao 40:654-7. 2008
    ..On the other hand, domestic scholars pay attention to the basis of the material research. It provides the overview of the materials for CAD/CAM in dentistry...
  80. ncbi Multiscale variation-aware techniques for high-performance digital microfluidic lab-on-a-chip component placement
    Chen Liao
    Department of Electrical and Computer Engineering, Michigan Technological University, Houghton, MI 49931, USA
    IEEE Trans Nanobioscience 10:51-8. 2011
    ..9% reduction in completion time. When considering variations, the variation-unaware design has the average yield of 2%, while our variation-aware technique always satisfies the yield constraint with only 7.7% completion time increase...
  81. ncbi Prospective observation of CAD/CAM titanium ceramic single crowns: a three-year follow up
    Arne F Boeckler
    Center for Oral Medicine, Department of Prosthodontics, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Prosthet Dent 102:290-7. 2009
    ..However, there is a lack of information about the clinical performance of CAD/CAM titanium ceramic single crowns...
  82. ncbi Clinical aspects and strategy for biomaterial engineering of an auricle based on three-dimensional stereolithography
    A Naumann
    Department of Otorhinolaryngology and Head and Neck Surgery, Ludwig Maximilian University, Marchioninistr 15, 81377 Munich, Germany
    Eur Arch Otorhinolaryngol 260:568-75. 2003
    ..Hyaff 11 seems to be a promising material for tissue engineering of cartilage transplants, and the application of this approach will improve conventional reconstructive surgery in the future...
  83. ncbi The efficacy of posterior three-unit zirconium-oxide-based ceramic fixed partial dental prostheses: a prospective clinical pilot study
    Ariel J Raigrodski
    Department of Restorative Dentistry, School of Dentistry, University of Washington, Seattle, USA
    J Prosthet Dent 96:237-44. 2006
    ..Although zirconium-oxide-based restorations for fixed partial denture prostheses (FPDPs) are available for use, clinical studies evaluating their longevity and related complications have not been published...
  84. ncbi Computer-aided design for three-dimensional titanium mesh used for repairing skull base bone defect in pediatric neurofibromatosis type 1. A novel approach combining biomodeling and neuronavigation
    Chieh Tsai Wu
    Department of Pediatric Neurosurgery, Chang Gung Children Hospital, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Pediatr Neurosurg 44:133-9. 2008
    ..This defect can be closed using bone grafts or titanium mesh. However, the results of this procedure are often unsustainable due to bone graft resorption and graft displacement...
  85. ncbi Quantified kinematics of the injury to the posterior cruciate ligament: a computer-aided design simulation study
    I A Karnezis
    Department of Orthopaedic Surgery, University of Bristol, UK
    Clin Biomech (Bristol, Avon) 16:54-60. 2001
    ..To quantify the kinematics of the injury to the posterior cruciate and the other major knee ligaments as a function of the knee flexion angle at the moment of impact...
  86. ncbi Fracture strength of all-ceramic crowns luted using two bonding methods
    Ahmed Attia
    Department of Conservative Dentistry and Fixed Prosthodontics, Faculty of Dentistry, Mansoura University, Egypt
    J Prosthet Dent 91:247-52. 2004
    ..Ceramic bonding systems using ceramic primers without the use of hydrofluoric acid have been introduced, but data about the efficiency of these systems are lacking...
  87. ncbi Retention of zirconium oxide ceramic crowns with three types of cement
    Rosario P Palacios
    Department of Restorative Dentistry, University of Washington, Seattle 98195 7456, USA
    J Prosthet Dent 96:104-14. 2006
    ..Information about the retentive strength of luting agents for zirconium oxide-based crowns is limited. It is unknown if this type of high-strength ceramic restoration requires adhesive cementation to enhance retention...
  88. ncbi Fabrication of porous polymeric matrix drug delivery devices using the selective laser sintering technique
    K F Leong
    Design Research Centre, School of Mechanical and Production Engineering, Nanyang Technological University, Singapore
    Proc Inst Mech Eng H 215:191-201. 2001
    ..The strategy of this research is to integrate computer aided design (CAD) and the SFF technique of selective laser sintering (SLS) to fabricate porous polymeric matrix drug ..
  89. ncbi The effect of multicolored machinable ceramics on the esthetics of all-ceramic crowns
    Sven Reich
    Faculty of Medicine, University of Erlangen Nuremberg, Germany
    J Prosthet Dent 88:44-9. 2002
    ..Whether multishaded blocks improve esthetic results and are a viable alternative to individually stained ceramics has not been fully determined...
  90. pmc Synthetic tetracycline-inducible regulatory networks: computer-aided design of dynamic phenotypes
    Vassilios Sotiropoulos
    Department of Chemical Engineering and Materials Science, and Digital Technology Center, University of Minnesota, 421 Washington Ave SE, Minneapolis, MN 55455 USA
    BMC Syst Biol 1:7. 2007
    ..Sophisticated algorithms can accurately capture the dynamical behavior of gene networks. With computer aided design, we aim to improve the synthesis of regulatory networks and propose new designs that enable tighter ..
  91. ncbi Marginal adaptation of three different zirconium dioxide three-unit fixed dental prostheses
    Wael Att
    Department of Prosthodontics, School of Dentistry, Albert Ludwigs University, Freiburg, Germany
    J Prosthet Dent 101:239-47. 2009
    ..Data on the marginal discrepancy of zirconia-based fixed dental prostheses made with different computer-aided design/computer-aided manufacturing technology is needed...
  92. ncbi Survival of ceramic computer-aided design/manufacturing crowns bonded to preparations with reduced macroretention geometry
    Andreas Bindl
    Clinic of the Division of Aesthetic and Computer Restorations, Department of Preventive Dentistry, Periodontology and Cariology, Center for Dental and Oral Medicine, University of Zurich, Switzerland
    Int J Prosthodont 18:219-24. 2005
    ....
  93. ncbi Acoustomechanical properties of open TTP titanium middle ear prostheses
    H P Zenner
    Department of Otolaryngology, The University of Tübingen, Germany
    Hear Res 192:36-46. 2004
    ..The identified material should serve to build CE and FDA approved prostheses for clinical use in patients...
  94. ncbi Late reconstruction of the complex orbital fractures with computer-aided design and computer-aided manufacturing technique
    Xianqun Fan
    Department of Ophthalmology, Ninth People s Hospital, Medical School, Shanghai Jiaotong University, Shanghai, P R China
    J Craniofac Surg 18:665-73. 2007
    ....
  95. ncbi [The use of CAD/CAM techniques in the repair of complex orbital fractures and the reposition of enophthalmos]
    Xian qun Fan
    Department of Ophthalmology, Ninth People s Hospital, Shanghai Second Medical University, Shanghai 200011, China
    Zhonghua Yan Ke Za Zhi 41:1092-7. 2005
    ..To reconstruct the three-dimensional (3 D) imaging and computer-generated models of the complex orbital fractures, and to develop a Computer-Aided Design/Computer-Aided Manufacture (CAD/CAM) system for orbital fracture repair...
  96. ncbi [Methodology of computer-aided design of automatic artificial tooth selection for complete denture]
    Yu guang Wang
    Center of Computerized Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China
    Beijing Da Xue Xue Bao 42:108-10. 2010
    ..To study the method of automatic tooth selection for computer-aided design in complete denture, evaluate the results by comparison with traditional denture tooth selection...
  97. ncbi Burs with guide pins for standardized tooth preparation
    K W Boening
    Department of Prosthetic Dentistry, Medical Faculty, Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
    Quintessence Int 32:191-7. 2001
    ..The aim of this study was to develop and test self-limiting diamond burs to ease precise chamfer preparation and to fulfill the special requirements of computer-aided design/computer-aided manufacturing and all-ceramic restorations...
  98. ncbi Immunophilins and HIV-1 V3 loop for structure-based anti-AIDS drug design
    Alexander M Andrianov
    Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich Street 5 2, 220141 Minsk, Republic of Belarus
    J Biomol Struct Dyn 26:445-54. 2009
    ....
  99. ncbi Dynamic analysis of the effects of upper lip pressure on the asymmetry of the facial skeleton in patients with unilateral complete cleft lip and palate
    Tomohisa Nagasao
    Department of Plastic and Reconstructive Surgery, Keio University Hospital, Tokyo, Japan
    Cleft Palate Craniofac J 46:154-60. 2009
    ..Our purpose was to assess quantitatively the effect of increased upper-lip pressure on asymmetry of the facial bones in patients with unilateral complete lip-alveolar-palatal clefts...
  100. ncbi Mandibular reconstruction using stereolithographic 3-dimensional printing modeling technology
    Adir Cohen
    Department of Oral and Maxillofacial Surgery, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:661-6. 2009
    ....
  101. ncbi Development of the first force-controlled robot for otoneurosurgery
    Philipp A Federspil
    Department of Otolaryngology Head and Neck Surgery, University of Saarland, Kirrberger Strasse, D 66421 Homburg Saar, Germany
    Laryngoscope 113:465-71. 2003
    ..In some surgical specialties (eg, orthopedics), robots are already used in the operating room for bony milling work. Otological surgery and otoneurosurgery may also greatly benefit from the enhanced precision of robotics...

Research Grants62

  1. Computer Aided Design of Complement Therapeutics
    John Lambris; Fiscal Year: 2007
    ..We believe that this methodology is general enough that we expect it will eventually be of broad use in the field of peptide-based drug design. [unreadable] [unreadable] [unreadable] [unreadable]..
  2. Development of an Inhibitor of Toxoplasma gondii
    Richard D Wood; Fiscal Year: 2010
    ..gondii, as treatments for toxoplasmosis which affects HIV/AIDS patients. ..
  3. Commercialization of Tissue Lined Stent Graft for Dialysis Access Failure
    DON GUSTAVSON; Fiscal Year: 2013
    ..Phase I is underway and we seek funding to accelerate development. Computer aided design (CAD) models will be tested for various non-clinical factors such as fluid flow analysis, risk analysis, ..
  4. Computer Modeling of Surgical Outcomes for Nasal Airway Obstruction
    John S Rhee; Fiscal Year: 2012
    ..Furthermore, with the universality of CT scans and the ability to post-process the "raw data", the potential for telemedicine consulting for difficult nasal airway cases would also become more appealing and fruitful. ..
  5. Rational Design of antivrials targeted to HIV-1 capsid
    Asim K Debnath; Fiscal Year: 2013
    ..The studies described in this proposal may lead to the development of a new class of antiretroviral therapeutics targeting the HIV-1 capsid. ..
  6. A Computational Approach to Developing Heterochiral Peptide Therapeutics
    Vikas Nanda; Fiscal Year: 2013
    ..Our laboratory is developing protCAD (protein Computer Aided Design) to simulate the impact of non-natural amino acids on structure and stability...
  7. Software for the accurate de novo 3D structure prediction of RNA
    FREDRICK OTIENO SIJENYI; Fiscal Year: 2012
    ..DNAS) has developed an RNA homology modeling software, NA-CAD (Nucleic Acid Computer Aided Design) that has a unique force field specifically optimized for RNA...
  8. Study of Chronic Fatigue Syndrome using comprehensive molecular profiling with ne
    NANCY GRACE KLIMAS; Fiscal Year: 2013
    ..abstract_text> ..
  9. A Low-Cost Upper-Extremity Prosthetic Interface
    ALWYN P JOHNSON; Fiscal Year: 2011
    ..The socket is easily adjustable for individual users, is comfortable and stable, and enables disadvantaged amputees to perform physically demanding tasks associated with agricultural work and subsistence farming. ..
  10. Computational design of protein-based modular small-molecule biosensors
    Tanja Kortemme; Fiscal Year: 2012
    ..The software and technology developed in this project will be widely available to researchers to improve biosensor design. ..
  11. HARVESTING AUTOLOGOUS PLATELETS FOR WOUND HEALING
    Don B Olsen; Fiscal Year: 2010
    ..Product development activities will include computer aided design and manufacturing, rapid prototyping, molding, assembly, preclinical testing, and establishing a quality ..
  12. Totally Bioresorbable Drug-eluting Peripheral Polymer Stents
    HOCK SENG TAN; Fiscal Year: 2012
    ..This novel system is Computer Aided Design (CAD) based and has the capability to directly produce bioresorbable polymer stents by using polymer ..
  13. Advanced software tools for planning the placement of skeletal fixation hardware
    John C Magill; Fiscal Year: 2013
    ..Better planning for surgery in the face and other parts of the skeleton will lead to reduced time and cost and improved aesthetic and functional outcomes. ..
  14. ADVANCED MICROFABRICATION TECHNOLOGY
    Larry Walker; Fiscal Year: 2012
    ....
  15. Computer-Aided Design of Anti-HIV Drugs
    William L Jorgensen; Fiscal Year: 2013
    ..Similar analyses are being carried out for the other prominent clinical variant, Lys103Asn;only a ca. 10-fold gain is needed to bring the potency towards strains with this replacement to the 10-nM level. ..
  16. COMPUTER SIMULATION OF ENZYMATIC REACTIONS
    Arieh Warshel; Fiscal Year: 2013
    ..has been the emergence of the field of enzyme design, with promising advances in directed evolution and in computer aided design. However, this progress has not yet led to designer enzymes that can rival native enzymes...
  17. A Novel Ear Camera for Making Custom-Fit Hearing Devices
    Ping Zhuang; Fiscal Year: 2003
    ..More importantly, the digital impression technology to be developed herein would improve the quality of fit, thus enhance the hearing functionality for impaired people. ..
  18. MACHINING AND POLISHING EFFECTS ON DENTAL CERAMICS
    Russell Giordano; Fiscal Year: 1999
    ..ceramic, a castable glass-ceramic(Dicor[TM]), an interpenetrating phase ceramic(Inceram[TM]) and CAD/CAM (computer aided design/computer aided machining) ceramic materials (Dicor MGC[TM] and Vitablocs[TM])...
  19. Ultrathin Intraoral 3D Camera
    Jason Geng; Fiscal Year: 2011
    ....
  20. Biodegradable Polymer Implants for Spinal Cord Repair
    Anthony Windebank; Fiscal Year: 2006
    ..Imaging with Micro-CT and MR microscopy will be combined with histological and functional assessments to measure success in promoting regeneration. ..
  21. A Low-Cost Upper-Extremity Prosthetic Interface
    ALWYN JOHNSON; Fiscal Year: 2009
    ..The socket requires negligible customization but delivers essential function and stability, enabling disadvantaged amputees to perform physically demanding tasks associated with agricultural work and subsistence farming. ..
  22. High Speed Low-Damage Dental Machining Center (Phase II)
    Said Jahanmir; Fiscal Year: 2010
    ..This new method for fabrication of dental restorations based on computer aided design and computer aided manufacturing (CAD/CAM) has revolutionized dentistry during the past decade...
  23. SOL-GEL DERIVED CONTINUOUS DUAL MATRIX COMPOSITES
    Robert Seghi; Fiscal Year: 1991
    ..The research and development efforts being made in the area of computer aided design and manufacturing (CAD/CAM) and adhesion technology presents some a very real possibility for ..
  24. High-Speed Low-Damage Dental Machining Center
    Said Jahanmir; Fiscal Year: 2007
    ..This new method for fabrication of Dental restorations based on computer aided design and computer aided manufacturing (CAD/CAM) has revolutionized Dentistry during the past decade...
  25. Computer-aided Design of Anti-cancer Drugs Targeting Protein Kinases
    Chung Wong; Fiscal Year: 2006
    ..Specific Aim 5 applies this refined five-tier hierarchical model to identify new anti-cancer drug candidates for the protein kinase targets EGFR, HER2, CDK2, and BCR-ABL. [unreadable] [unreadable] [unreadable]..
  26. Technological Development Towards a Cortical Prosthesis
    Patrick Rousche; Fiscal Year: 2005
    ..abstract_text> ..
  27. BIOLOGICAL NANOSTRUCTURES AND NANO-NETWORKS
    GLEN EVANS; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS. The work will result in novel genes that encode biochemical functions. This new technology would have applications in the development of medical diagnostics. ..
  28. One dimensional transport equations for CE systems by asymptotic homogenization
    Sandip Ghosal; Fiscal Year: 2009
    ..many orders of magnitude the computational effort involved in the numerical simulation protocols used in computer aided design of microfluidic systems...
  29. Molecular Docking and Imaging Devices for Drug Delivery
    Yihua Yu; Fiscal Year: 2004
    ..Structural and imaging properties of the integrated docking/imaging device will be characterized by NMR spectroscopy. The long-term goal is to apply the engineered devices in radioimmunotherapy of solid tumors. ..
  30. True 3D Display for IGRI
    Jason Geng; Fiscal Year: 2009
    ..g., 3D TV, virtual reality, advertizing, computer aided design, scientific computing, video games, stadium displays, etc...
  31. Hearing Aids:Computer-Aided Design and Manufacturing
    Ping Zhuang; Fiscal Year: 2005
    ..Our Phase 2 program is geared toward further improve the technology and working closely with hearing aid manufacturers to develop and test field deployable prototypes. ..
  32. Custom Hearing Instruments by Computer-Aided Design
    Ping Zhuang; Fiscal Year: 2002
    ..A prototype of 3D camera system will be demonstrated to acquire ear impression model that can be used to produce customer shell pieces. ..
  33. Economical CAD/CAM System to Produce Dental Restorations
    RAY MORROW; Fiscal Year: 2002
    The objective of this project is the development of a portable, moderately priced Computer Aided Design/Computer Aided Manufacturing (CAD/CAM) system for Dental restorations...
  34. NOVEL COMPOUNDS WHICH CIRCUMVENT MULTIDRUG RESISTANCE
    Charles Smith; Fiscal Year: 2001
    ..These studies should allow a critical evaluation of the potential utility of these novel compounds as clinical agents. ..
  35. DESIGN AND DEMONSTRATION OF A VENTILATION SYSTEM
    Robert Heinsohn; Fiscal Year: 1980
    ..design and demonstrate an industrial ventilation system for portable welding and grinding and to develop a computer aided design program that can be used by engineers to design similar ventilation systems...
  36. Center for Design:Biomimetic Nanoconductors (RMI)
    Eric Jakobsson; Fiscal Year: 2004
    ..4) We will aim to build working prototypes of designed nanoscale ion transporters. ..
  37. FMRI task design and statistical analysis software
    Eric Halgren; Fiscal Year: 2003
    ..1% of the fMRI equipment cost. Put another way, the proposed software could have the number offMRI sessions needed to achieve a given level of significance, and thus would play for itself after a single study. ..
  38. First-Principles, Computer-Aided Nanosystem Design and Analysis
    Peter Ortoleva; Fiscal Year: 2009
    ..This software will lead to improved strategies for cancer and gene therapy, refined medical imaging, and the development of magnetic field-guided cancer treatments to the site of the tumor or tissue damage. ..
  39. BIOCOMPLEXITY:ANALYSIS, DESIGN, EVOLUTION-COMPLEX GENES
    Adam Arkin; Fiscal Year: 2004
    ..abstract_text> ..
  40. Hierarchical Modeling/Ion Channel and Receptor Mechanism
    Maria Kurnikova; Fiscal Year: 2009
    ....
  41. Fluorescence-Based Glucose Sensors
    Dale Drueckhammer; Fiscal Year: 2005
    ..Initial structures will be further modified to tune the sensor to physiological glucose concentration and other practical issues in glucose sensor development will be addressed. ..
  42. A Wearable Multi-Sensor Navigation Device for the Visually Impaired
    Vladimir Kulyukin; Fiscal Year: 2006
    ..sensory data collection, testing of sensor fusion algorithms with respect to localization accuracy, and 3D computer aided design (CAD)...
  43. COMPUTERIZED MAPPING OF OUTDOOR TRAILS FOR ACCESSIBILITY
    PETER AXELSON; Fiscal Year: 1993
    ..The data will be processed using Computer Aided Design software into a map with text that will be printed and distributed through a variety of mechanisms.
  44. COMPUTER-AIDED DESIGN, SYNTHESIS, AND TESTING OF A NOVEL FAMILY OF TRIAZOLE-BASED
    Sean Ekins; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  45. Synthesis of Novel Anticancer Agents
    MARISA KOZLOWSKI; Fiscal Year: 2007
    ..Routes to symmetric and dissymmetric chiral binaphthyl, perylenequinone, bisnaphthopyrone, bisanthraquinone, hypericin, and bisflavone natural products are presented. ..
  46. Designing Asymmetric Ligands Using Computational Techniques
    MARISA KOZLOWSKI; Fiscal Year: 2009
    ..The current proposal will create or retain four jobs. ..
  47. Real-time in Vivo Dosimetry in Radiation Therapy Using Scintillation Detectors
    Sam Beddar; Fiscal Year: 2009
    ..The resulting data can also be used to study dose- related treatment side effects. The ultimate goal of utilizing this method is to improve the delivery of radiotherapy treatments and the quality of life of radiotherapy patients. ..
  48. Intervertebral Disc Response to Cyclic Loading in Vivo
    CLARK HUNG; Fiscal Year: 2005
    ..abstract_text> ..
  49. In Vivo Assessment of AAA Biomechanics with Dynamic Wall Properties
    ENDER FINOL; Fiscal Year: 2008
    ..This methodology is expected to greatly enhance the presurgical planning capabilities of vascular surgeries and endovascular therapies in the future management of cardiovascular diseases. [unreadable] [unreadable] [unreadable]..
  50. The SMD-Relaxed Complex Method for Drug Design
    Rommie Amaro; Fiscal Year: 2008
    ..The success of this new approach will be demonstrated on an essential RNA editing enzyme found in the trypanosomatid pathogens, which are responsible for several devastating tropical diseases. [unreadable] [unreadable] [unreadable]..
  51. RESEARCH TRAINING IN IMAGING METHODS FOR CANCER
    Stephen Moore; Fiscal Year: 2002
    ..Some didactic course work is offered at Harvard Medical School, Harvard School of Public Health, and Massachusetts Institute of Technology. The patient population includes those treated at Dana-Farber-Partners Cancer Care. ..
  52. HIGH RESOLUTION CERVICAL CAROTID IMAGING WITH MR
    Dennis Parker; Fiscal Year: 2009
    ..The remaining 10% effort, at 1.5T, will provide a valid baseline for comparison with 3.0T. We believe that each aspect of this work will help open the door for improved longitudinal studies of the carotid artery at 3.0T. ..
  53. IMPROVING COMBINED BUPRENORPHINE-BEHAVIORAL TREATMENT
    WARREN BICKEL; Fiscal Year: 2009
    ..Finally, this project will contribute positively to this region's public health by providing a substantial portion of all outpatient pharmacotherapy services for opioid dependence in the State of Vermont. ..
  54. High Resolution Imaging Endoscopic Probe
    Nicusor Iftimia; Fiscal Year: 2006
    ..It is evident that earlier diagnosis results in an improved outcome, decreased morbidity and reduced mortality from disease. [unreadable] [unreadable] [unreadable]..
  55. Feasibility of CT in high risk breast cancer patients
    John Boone; Fiscal Year: 2003
    ..The results of this investigation should provide a clear understanding of the potential of breast CT as a tool to reduce breast cancer mortality in the population of women with dire risk of breast cancer. ..
  56. CENTER FOR GAMMA RAY IMAGING
    HARRISON BARRETT; Fiscal Year: 2002
    ..Results of the resource will be disseminated by innovative uses of the Internet as well as through traditional scientific publishing. ..
  57. Multiple Factors Affecting Placebo Response in PD
    Christopher Goetz; Fiscal Year: 2004
    ..Defining these determinant influences will help enhance placebo responses in clinical practice and control them in clinical trials. ..
  58. Optimizing Mandibular Scaffold Modulus/Porosity Balance
    Scott Hollister; Fiscal Year: 2009
    ..This information will provide guidelines for designing scaffolds to optimize transition from scaffold load bearing to bone regeneration and load bearing. ..
  59. Image Reconstruction with Solid Srate SPECR
    LAWRENCE ZENG; Fiscal Year: 2005
    ..abstract_text> ..
  60. MRI Gradient Coils with Improved Stimulation Threshold
    Christopher Collins; Fiscal Year: 2005
    ..This work will lay the foundation for development of clinically useful head and body gradient coils that can outperform existing coils before inducing PNS. ..
  61. MR Physics Simulation Package for Pulse, Sequence, and Hardware Design
    Christopher Collins; Fiscal Year: 2009
    ....
  62. Computational Approach to Ligand Discovery for LPA GPCR and PPAR
    Abby L Parrill; Fiscal Year: 2010
    ..This research can therefore lead to new treatments for cardiovascular disease and cancer. ..