computer assisted image processing

Summary

Summary: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.

Top Publications

  1. ncbi Nonrigid registration using free-form deformations: application to breast MR images
    D Rueckert
    Division of Radiological Sciences and Medical Engineering, Guy s, King s, and St Thomas School of Medicine, King s College London, Guy s Hospital, London, UK
    IEEE Trans Med Imaging 18:712-21. 1999
  2. pmc A method for functional network connectivity among spatially independent resting-state components in schizophrenia
    Madiha J Jafri
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA
    Neuroimage 39:1666-81. 2008
  3. pmc Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline
    Yong Fan
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Neuroimage 39:1731-43. 2008
  4. pmc Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
    P Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Room 3N202, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:19649-54. 2007
  5. pmc CellProfiler: image analysis software for identifying and quantifying cell phenotypes
    Anne E Carpenter
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Genome Biol 7:R100. 2006
  6. ncbi A voxel-based morphometric study of ageing in 465 normal adult human brains
    C D Good
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom
    Neuroimage 14:21-36. 2001
  7. ncbi Unified segmentation
    John Ashburner
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London, WC1N 3BG, UK
    Neuroimage 26:839-51. 2005
  8. ncbi Cortical surface-based analysis. I. Segmentation and surface reconstruction
    A M Dale
    Massachusetts General Hosp Harvard Medical School, Building 149, Charlestown, Massachusetts, 02129, USA
    Neuroimage 9:179-94. 1999
  9. ncbi Temporal autocorrelation in univariate linear modeling of FMRI data
    M W Woolrich
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Engineering Science, University of Oxford, Oxford OX3 9DU, United Kingdom
    Neuroimage 14:1370-86. 2001
  10. ncbi Optimized EPI for fMRI studies of the orbitofrontal cortex
    R Deichmann
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, UK
    Neuroimage 19:430-41. 2003

Detail Information

Publications282 found, 100 shown here

  1. ncbi Nonrigid registration using free-form deformations: application to breast MR images
    D Rueckert
    Division of Radiological Sciences and Medical Engineering, Guy s, King s, and St Thomas School of Medicine, King s College London, Guy s Hospital, London, UK
    IEEE Trans Med Imaging 18:712-21. 1999
    ..The results clearly indicate that the nonrigid registration algorithm is much better able to recover the motion and deformation of the breast than rigid or affine registration algorithms...
  2. pmc A method for functional network connectivity among spatially independent resting-state components in schizophrenia
    Madiha J Jafri
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA
    Neuroimage 39:1666-81. 2008
    ..Significant differences between patient and control connectivity in different networks were revealed possibly reflecting deficiencies in cortical processing in patients...
  3. pmc Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline
    Yong Fan
    Section of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    Neuroimage 39:1731-43. 2008
    ....
  4. pmc Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
    P Shaw
    Child Psychiatry Branch, National Institute of Mental Health, Room 3N202, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 104:19649-54. 2007
    ..Neuroanatomic documentation of a delay in regional cortical maturation in ADHD has not been previously reported...
  5. pmc CellProfiler: image analysis software for identifying and quantifying cell phenotypes
    Anne E Carpenter
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Genome Biol 7:R100. 2006
    ....
  6. ncbi A voxel-based morphometric study of ageing in 465 normal adult human brains
    C D Good
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom
    Neuroimage 14:21-36. 2001
    ..There was no interaction of age with sex for regionally specific effects. These results corroborate previous reports and indicate that VBM is a useful technique for studying structural brain correlates of ageing through life in humans...
  7. ncbi Unified segmentation
    John Ashburner
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London, WC1N 3BG, UK
    Neuroimage 26:839-51. 2005
    ..A strategy for optimising the model parameters is described, along with the requisite partial derivatives of the objective function...
  8. ncbi Cortical surface-based analysis. I. Segmentation and surface reconstruction
    A M Dale
    Massachusetts General Hosp Harvard Medical School, Building 149, Charlestown, Massachusetts, 02129, USA
    Neuroimage 9:179-94. 1999
    ..Automated routines for unfolding and flattening the cortical surface are described in a companion paper. These procedures allow for the routine use of cortical surface-based analysis and visualization methods in functional brain imaging...
  9. ncbi Temporal autocorrelation in univariate linear modeling of FMRI data
    M W Woolrich
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Engineering Science, University of Oxford, Oxford OX3 9DU, United Kingdom
    Neuroimage 14:1370-86. 2001
    ..Using this approach when prewhitening reduced bias to close to zero at probability levels as low as 1 x 10(-5)...
  10. ncbi Optimized EPI for fMRI studies of the orbitofrontal cortex
    R Deichmann
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, UK
    Neuroimage 19:430-41. 2003
    ..In contrast to several other techniques proposed in the literature for reducing susceptibility effects, this method does not compromise the temporal resolution and is therefore applicable to event-related studies...
  11. pmc Serial block-face scanning electron microscopy to reconstruct three-dimensional tissue nanostructure
    Winfried Denk
    Max Planck Institute for Medical Research, Heidelberg, Germany
    PLoS Biol 2:e329. 2004
    ..This opens the possibility of automatically obtaining the electron-microscope-level 3D datasets needed to completely reconstruct the connectivity of neuronal circuits...
  12. ncbi Learning the value of information in an uncertain world
    Timothy E J Behrens
    FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Neurosci 10:1214-21. 2007
    ..Furthermore, variations in this ACC signal across the population predict variations in subject learning rates. Our results provide a formal account of how we weigh our different experiences in guiding our future actions...
  13. ncbi General multilevel linear modeling for group analysis in FMRI
    Christian F Beckmann
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, OX3 9DU, UK
    Neuroimage 20:1052-63. 2003
    ....
  14. ncbi Distributed neural representation of expected value
    Brian Knutson
    Department of Psychology, Stanford University, Stanford, California 94305, USA
    J Neurosci 25:4806-12. 2005
    ....
  15. ncbi Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing
    M Vigneau
    Groupe d Imagerie Neurofonctionnelle, UMR 6194, CNRS CEA Caen and Paris 5 Universities, GIP Cyceron, Boulevard Henri Becquerel, BP 5229, 14074 Caen Cedex, France
    Neuroimage 30:1414-32. 2006
    ..These results argue for large-scale architecture networks rather than modular organization of language in the left hemisphere...
  16. ncbi CellProfiler: free, versatile software for automated biological image analysis
    Michael R Lamprecht
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Biotechniques 42:71-5. 2007
    ....
  17. ncbi Image distortion correction in fMRI: A quantitative evaluation
    Chloe Hutton
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London WCIN 3BG, United Kingdom
    Neuroimage 16:217-40. 2002
    ..However, we suggest that the variance between successively measured field maps introduces additional unwanted variance in the voxel time-series and is therefore not adequate to correct for time-varying distortions...
  18. pmc The functional neuroanatomy of autobiographical memory: a meta-analysis
    Eva Svoboda
    Rotman Research Institute, Baycrest, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada
    Neuropsychologia 44:2189-208. 2006
    ..Finally, emotional events produced a shift in lateralization of the AM network with activation observed in emotion-centered regions and deactivation (or lack of activation) observed in regions associated with cognitive processes...
  19. ncbi Generalized autocalibrating partially parallel acquisitions (GRAPPA)
    Mark A Griswold
    Julius Maximilians Universitat Wurzburg, Physikalisches Institut, Wurzburg, Germany
    Magn Reson Med 47:1202-10. 2002
    ..Finally, in vivo GRAPPA images are shown which demonstrate the utility of the technique...
  20. pmc Array tomography: a new tool for imaging the molecular architecture and ultrastructure of neural circuits
    Kristina D Micheva
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA
    Neuron 55:25-36. 2007
    ..The application of array tomography can reveal important but previously unseen features of brain molecular architecture...
  21. ncbi A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume
    Randy L Buckner
    Department of Psychology, HHMI at Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Neuroimage 23:724-38. 2004
    ..Thus, atlas normalization provides a common framework for both morphometric and functional data analysis...
  22. ncbi Modeling geometric deformations in EPI time series
    J L Andersson
    The Wellcome Department of Cognitive Neurology, London, United Kingdom
    Neuroimage 13:903-19. 2001
    ..An experiment on a subject performing voluntary movements in the scanner yielded plausible estimates of the deformation fields and their application to "unwarp" the time series significantly reduced movement-related variance...
  23. ncbi Functional specialization within rostral prefrontal cortex (area 10): a meta-analysis
    Sam J Gilbert
    University College London, UK
    J Cogn Neurosci 18:932-48. 2006
    ..These results point to considerable functional segregation within rostral prefrontal cortex...
  24. ncbi Beyond threat: amygdala reactivity across multiple expressions of facial affect
    Daniel A Fitzgerald
    Department of Psychiatry, The University of Chicago, 5841 South Maryland Avenue MC3077 L 466C, Chicago, IL 60637 1470, USA
    Neuroimage 30:1441-8. 2006
    ..These results challenge the notion that the amygdala has a specialized role in processing certain emotions and suggest that the amygdala may have a more general-purpose function in processing salient information from faces...
  25. pmc Intrinsic functional relations between human cerebral cortex and thalamus
    Dongyang Zhang
    Washington University, Department of Radiology, Campus Box 8225, 510 South Kingshighway Blvd, St Louis, MO 63110, USA
    J Neurophysiol 100:1740-8. 2008
    ..These results extend our understanding of the intrinsic network organization of the human brain to the thalamus and highlight the potential of resting-state fMRI BOLD imaging to elucidate thalamocortical relationships...
  26. ncbi Automatically parcellating the human cerebral cortex
    Bruce Fischl
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH MIT Harvard Medical School, Massachusetts General Hospital, 13th Street, Charlestown, MA 02129, USA
    Cereb Cortex 14:11-22. 2004
    ..Examples are given from two different training sets generated using different neuroanatomical conventions, illustrating the flexibility of the algorithm. The technique is shown to be comparable in accuracy to manual labeling...
  27. ncbi Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain
    Hans Ulrich Dodt
    Max Planck Institute of Psychiatry, Kraepelinstr 2, 80804 Munich, Germany
    Nat Methods 4:331-6. 2007
    ..Our method is ideally suited for high-throughput phenotype screening of transgenic mice and thus will benefit the investigation of disease models...
  28. ncbi Quantification of immunohistochemistry--issues concerning methods, utility and semiquantitative assessment II
    C R Taylor
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Histopathology 49:411-24. 2006
    ....
  29. ncbi Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
    Mukesh G Harisinghani
    Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 348:2491-9. 2003
    ....
  30. ncbi Signal processing in magnetoencephalography
    J Vrba
    CTF Systems Inc, A subsidiary of VSM MedTech Ltd, 15-1750 McLean Avenue, British Columbia V3C 1M9, Port Coquitlam, Canada
    Methods 25:249-71. 2001
    ..The use of synthetic aperture magnetometry (a class of beamformers) is illustrated in examples of interictal epileptic spiking and voluntary hand-motor activity...
  31. ncbi The representation of object concepts in the brain
    Alex Martin
    Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, Maryland 20892 1366, USA
    Annu Rev Psychol 58:25-45. 2007
    ..However, some property-based regions seem to show a categorical organization, thus providing evidence consistent with category-based, domain-specific formulations as well...
  32. ncbi Dissociable executive functions in the dynamic control of behavior: inhibition, error detection, and correction
    H Garavan
    Department of Psychology, Trinity College Dublin, Dublin 2, Ireland
    Neuroimage 17:1820-9. 2002
    ..The results highlight how higher cognitive functions responsible for behavioral control can result from the dynamic interplay of distinct cortical systems...
  33. ncbi Dynamics of language reorganization after stroke
    Dorothee Saur
    Department of Neurology, University Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Brain 129:1371-84. 2006
    ..Thereafter, a normalization of activation is observed, possibly reflecting consolidation in the language system...
  34. ncbi Feature point tracking and trajectory analysis for video imaging in cell biology
    I F Sbalzarini
    Institute of Computational Science, ETH Zurich, 8092 Zurich, Switzerland
    J Struct Biol 151:182-95. 2005
    ..The present automated tracking process enables the quantification of dispersive processes in cell biology using techniques such as moment scaling spectra...
  35. ncbi Meta-analysis of gray matter anomalies in schizophrenia: application of anatomic likelihood estimation and network analysis
    David C Glahn
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 64:774-81. 2008
    ..In this study, we performed a voxelwise, coordinate-based meta-analysis to better conceptualize the neuroanatomic correlates of schizophrenia...
  36. ncbi The gateway hypothesis of rostral prefrontal cortex (area 10) function
    Paul W Burgess
    Institute of Cognitive Neuroscience and Psychology Department, University College London, London, WC1E 6BT, UK
    Trends Cogn Sci 11:290-8. 2007
    ..e. the 'thoughts in our head'). In this way, investigations into the functions of rostral PFC will reveal key new insights into how human and non-human mental abilities differ...
  37. ncbi An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets
    Joseph A Maldjian
    Department of Radiology, Wake Forest University Health Sciences Center, Winston Salem, NC 27157, USA
    Neuroimage 19:1233-9. 2003
    ..This tool represents a necessary evolution in fMRI data analysis for testing of more spatially complex hypotheses...
  38. ncbi A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRI
    Brian Knutson
    Department of Psychology, Building 420, Jordan Hall, Stanford University, Stanford, CA 94305 2130, USA
    Neuroimage 18:263-72. 2003
    ..00 win, MPFC activity decreased, relative to outcomes with no incentive value. These findings suggest that in the context of processing monetary rewards, a region of the MPFC preferentially tracks rewarding outcomes...
  39. pmc Retrovirus envelope protein complex structure in situ studied by cryo-electron tomography
    Friedrich Förster
    Abteilung für Molekulare Strukturbiologie, Max Planck Institut fur Biochemie, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Proc Natl Acad Sci U S A 102:4729-34. 2005
    ..This study thus provides 3D structural information regarding the prefusion conformation of an intact unstained retrovirus surface protein...
  40. ncbi Motion correction and the use of motion covariates in multiple-subject fMRI analysis
    Tom Johnstone
    Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Hum Brain Mapp 27:779-88. 2006
    ..Based on these results, we present a general strategy for block designs, event-related designs, and hybrid designs to identify and eliminate probable motion artifacts while maximizing sensitivity to true activations...
  41. ncbi Applying watershed algorithms to the segmentation of clustered nuclei
    N Malpica
    Grupo de Bioingenieria y Telemedicina, Universidad Politecnica de Madrid, Spain
    Cytometry 28:289-97. 1997
    ..Using this algorithm, almost 90% of the test clusters were correctly segmented in peripheral blood and bone marrow preparations. The algorithm was valid for both types of samples, using the appropriate markers and transformations...
  42. ncbi Opponent appetitive-aversive neural processes underlie predictive learning of pain relief
    Ben Seymour
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nat Neurosci 8:1234-40. 2005
    ..This dual coding has parallels to 'opponent process' theories in psychology and promotes a formal account of prediction and expectation during pain...
  43. ncbi Structural studies by electron tomography: from cells to molecules
    Vladan Lucic
    Department of Structural Biology, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    Annu Rev Biochem 74:833-65. 2005
    ....
  44. ncbi A neural network classifier capable of recognizing the patterns of all major subcellular structures in fluorescence microscope images of HeLa cells
    M V Boland
    Center for Light Microscope Imaging and Biotechnology, Biomedical and Health Engineering Program, Carnegie Mellon University, 4400 Fifth Ave, Pittsburgh, PA 15213, USA
    Bioinformatics 17:1213-23. 2001
    ..The scripts and source code generated for this work are available at http://murphylab.web.cmu.edu/software. CONTACT: murphy@cmu.edu..
  45. ncbi T cell receptor signaling precedes immunological synapse formation
    Kyeong Hee Lee
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Box 8118, Saint Louis, MO 63110, USA
    Science 295:1539-42. 2002
    ..These data suggest that many hours of TCR signaling are not required for T cell activation. These observations challenge current ideas about the role of immunological synapses in T cell activation...
  46. ncbi Towards neural circuit reconstruction with volume electron microscopy techniques
    Kevin L Briggman
    Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Curr Opin Neurobiol 16:562-70. 2006
    ..Such reconstructions of complete neural wiring diagrams could rekindle the tradition of relating neural function to the underlying neuroanatomical circuitry...
  47. ncbi The problem of functional localization in the human brain
    Matthew Brett
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Nat Rev Neurosci 3:243-9. 2002
    ..These problems cause uncertainty in localization, which limits the effective resolution of functional imaging, especially for brain areas involved in higher cognitive function...
  48. ncbi Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal
    Richard G Wise
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Neuroimage 21:1652-64. 2004
    ..These fluctuations are a source of physiological noise and a potentially important confounding factor in fMRI paradigms that modify breathing. However, they can also be used for mapping regional vascular responsiveness to CO(2)...
  49. ncbi Brain activity varies with modulation of dynamic pitch variance in sentence melody
    Martin Meyer
    Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
    Brain Lang 89:277-89. 2004
    ..Finally, it appears that brain areas which subserve speech (frontal operculum) and premotor functions (Rolandic operculum) coincidently support the processing of intonation contour in spoken sentence comprehension...
  50. ncbi Dissociating the human language pathways with high angular resolution diffusion fiber tractography
    Stephen Frey
    Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurosci 28:11435-44. 2008
    ..Thus, monkey and human evidence suggests that the connections of areas 44 and 45 are much more differentiated than had previously been thought and provide the basis for studies searching for their differential contribution in function...
  51. pmc Genes required for mitotic spindle assembly in Drosophila S2 cells
    Gohta Goshima
    Howard Hughes Medical Institute and the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Science 316:417-21. 2007
    ..The screen, in combination with a variety of secondary assays, led to new insights into how spindle microtubules are generated; how centrosomes are positioned; and how centrioles, centrosomes, and kinetochores are assembled...
  52. ncbi Dissociable controlled retrieval and generalized selection mechanisms in ventrolateral prefrontal cortex
    David Badre
    Department of Psychology and Neurosciences Program, Stanford University, Stanford, California 94305, USA
    Neuron 47:907-18. 2005
    ..Distinct PFC mechanisms mediate top-down retrieval and postretrieval selection...
  53. pmc Separable forms of reality monitoring supported by anterior prefrontal cortex
    Jon S Simons
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    J Cogn Neurosci 20:447-57. 2008
    ..The observation of significant correlations between reduced medial anterior prefrontal signal and scores on such measures corroborates these theoretical links...
  54. ncbi The human visual cortex
    Kalanit Grill-Spector
    Department of Psychology and Neuroscience, Stanford University, Stanford, California 94305 2130, USA
    Annu Rev Neurosci 27:649-77. 2004
    ..Here we review recent findings and methods employed to uncover the functional properties of the human visual cortex focusing on two themes: functional specialization and hierarchical processing...
  55. ncbi Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference
    Stephen M Smith
    FMRIB Oxford University Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Neuroimage 44:83-98. 2009
    ..We also show an example on a real imaging dataset, suggesting that TFCE does indeed provide not just improved sensitivity, but richer and more interpretable output than cluster-based thresholding...
  56. ncbi Quantification of immunohistochemistry--issues concerning methods, utility and semiquantitative assessment I
    R A Walker
    Department of Cancer Studies and Molecular Medicine, Leicester Royal Infirmary, Leicester, UK
    Histopathology 49:406-10. 2006
    ..Improvements in automated analysis with wider applicability could lead to standardization...
  57. ncbi Combining intensity, edge and shape information for 2D and 3D segmentation of cell nuclei in tissue sections
    C Wählby
    Centre for Image Analysis, Uppsala University, Sweden
    J Microsc 215:67-76. 2004
    ..This automated system was verified by comparison with manual counts from the same image fields. About 90% correct segmentation was achieved for two- as well as three-dimensional images...
  58. ncbi Focal thinning of the cerebral cortex in multiple sclerosis
    Michael Sailer
    Otto von Guericke University Magdeburg, Leipzigerstrasse 44, 39120 Magdeburg, Germany
    Brain 126:1734-44. 2003
    ..The data provide new insight into the cortical pathology in multiple sclerosis patients, revealing focal cortical thinning beside an overall reduction of the cortical thickness with disease progression...
  59. ncbi Why voxel-based morphometry should be used
    J Ashburner
    The Wellcome Department of Cognitive Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 14:1238-43. 2001
    ..We first review the tenets of VBM, paying particular attention to the relationship between VBM and tensor-based morphometry. The last two sections of this response deal with the specific concerns raised by Dr. Bookstein...
  60. ncbi The contribution of the insula to motor aspects of speech production: a review and a hypothesis
    Hermann Ackermann
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Brain Lang 89:320-8. 2004
    ..In line with this suggestion, a further study of our group (Ackermann et al., 2001) provided first evidence that differential hemispheric filtering might be bound to insular cortex...
  61. ncbi Natural image statistics and neural representation
    E P Simoncelli
    Howard Hughes Medical Institute, Center for Neural Science, and Courant Institute of Mathematical Sciences, New York University, New York, NY 10003 USA
    Annu Rev Neurosci 24:1193-216. 2001
    ....
  62. ncbi Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data
    Stephen M Smith
    Oxford University Centre for Functional MRI of the Brain FMRIB, Dept Clinical Neurology, University of Oxford, UK
    Neuroimage 31:1487-505. 2006
    ..TBSS aims to improve the sensitivity, objectivity and interpretability of analysis of multi-subject diffusion imaging studies. We describe TBSS in detail and present example TBSS results from several diffusion imaging studies...
  63. ncbi Thinning of the cerebral cortex in aging
    David H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA
    Cereb Cortex 14:721-30. 2004
    ..These findings demonstrate that cortical thinning occurs by middle age and spans widespread cortical regions that include primary as well as association cortex...
  64. ncbi Reduced cortical thickness in first episode schizophrenia
    C Christoph Schultz
    Department of Psychiatry and Psychotherapy, Friedrich Schiller University Jena, Philosophenweg 3, 07740 Jena, Germany
    Schizophr Res 116:204-9. 2010
    ..In an extension of these earlier studies, we used an entire cortex vertex-wise approach and an automated clustering for the detection and exact quantification of cortical thickness alterations in first episode schizophrenia...
  65. ncbi Reproducibility of dynamic contrast-enhanced MRI in human muscle and tumours: comparison of quantitative and semi-quantitative analysis
    Susan M Galbraith
    Gray Cancer Institute, Mount Vernon Hospital, Middlesex HA6 2JR, UK
    NMR Biomed 15:132-42. 2002
    ..Pixel analyses slightly improve reproducibility estimates and retain information about spatial heterogeneity. Reproducibility studies are recommended when treatment effects are being monitored...
  66. ncbi A diffusion tensor imaging study of fasciculi in schizophrenia
    Sukhwinder S Shergill
    Institute of Psychiatry, Kings College London, De Crespigny Park, UK
    Am J Psychiatry 164:467-73. 2007
    ..This study used diffusion tensor imaging to examine the integrity of the major white matter fasciculi, which connects the frontal and temporal-parietal cortices, and the corpus callosum in patients with schizophrenia...
  67. ncbi Valid conjunction inference with the minimum statistic
    Thomas Nichols
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Neuroimage 25:653-60. 2005
    ..This result holds even if the comparisons are not independent. We suggest that the revised test proposed here is the appropriate means for conjunction inference in neuroimaging...
  68. ncbi A global optimisation method for robust affine registration of brain images
    M Jenkinson
    University of Oxford, John Radcliffe Hospital, FMRIB Centre, Oxford OX3 9DU, UK
    Med Image Anal 5:143-56. 2001
    ....
  69. pmc The state of the art in the analysis of two-dimensional gel electrophoresis images
    Matthias Berth
    DECODON GmbH, Rathenau Strasse 49a, 17489 Greifswald, Germany
    Appl Microbiol Biotechnol 76:1223-43. 2007
    ..We close with an overview of visualization and presentation methods (proteome maps) and current challenges in the field...
  70. ncbi Extended confocal microscopy of myocardial laminae and collagen network
    A A Young
    Department of Physiology, School of Medicine, University of Auckland, New Zealand
    J Microsc 192:139-50. 1998
    ....
  71. ncbi A spatially unbiased atlas template of the human cerebellum
    Jorn Diedrichsen
    Laboratory for Computational Motor Control, Department for Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuroimage 33:127-38. 2006
    ..San Diego: Academic Press) and surface-based (Van Essen, D.C. (2002a) Surface-based atlases of cerebellar cortex in the human, macaque, and mouse. Ann. N. Y. Acad. Sci. 978:468-479.) atlas of one individual, the "colin27"-brain...
  72. ncbi CT perfusion for the monitoring of neoadjuvant chemotherapy and radiation therapy in rectal carcinoma: initial experience
    Massimo Bellomi
    School of Medicine, University of Milan, Milan, Italy
    Radiology 244:486-93. 2007
    ....
  73. pmc How long to scan? The relationship between fMRI temporal signal to noise ratio and necessary scan duration
    Kevin Murphy
    Section on Functional Imaging Methods, National Institute of Mental Health, NIH, Bethesda, MD 20892 1148, USA
    Neuroimage 34:565-74. 2007
    ..The implication is that at these resolutions, TSNR is likely to be critical for determining success or failure of an experiment...
  74. ncbi Abnormal activity patterns in premotor cortex during sequence learning in autistic patients
    Ralph Axel Müller
    Department of Psychology, San Diego State University, San Diego, California, USA
    Biol Psychiatry 56:323-32. 2004
    ..Studies in healthy adults suggest reduced premotor and increased prefrontal activity during advanced learning stages. We examined hemodynamic changes during visuomotor learning in autistic patients...
  75. pmc Prefrontal cortex volumes in adolescents with alcohol use disorders: unique gender effects
    Krista Lisdahl Medina
    Department of Psychiatry, University of California, San Diego, California, USA
    Alcohol Clin Exp Res 32:386-94. 2008
    ..This study examined PFC volumes in male and female adolescents with AUD who did not meet criteria for comorbid mood or attention disorders...
  76. pmc The neural correlates of verbal and nonverbal semantic processing deficits in neurodegenerative disease
    Christopher R Butler
    Division of Clinical Neurosciences, University of Edinburgh, Scotland, UK
    Cogn Behav Neurol 22:73-80. 2009
    ..To investigate the neural correlates of verbal and nonverbal semantic processing in neurodegenerative disease...
  77. ncbi Comparison of unilateral and bilateral complex finger tapping-related activation in premotor and primary motor cortex
    Craig Horenstein
    Cleveland Clinic, Ohio, USA
    Hum Brain Mapp 30:1397-412. 2009
    ....
  78. ncbi Cortical responses to self and others
    Amra Hodzic
    Department of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt am Main, Germany
    Hum Brain Mapp 30:951-62. 2009
    ..The latter appears to be accomplished by a network in right hemisphere comprising the fusiform body area, regions of the superior parietal lobe, the inferior parietal cortex, and the middle frontal gyrus...
  79. ncbi Detecting changes in nonisotropic images
    K J Worsley
    Department of Mathematics and Statistics, McGill University, Montreal, Quebec, Canada
    Hum Brain Mapp 8:98-101. 1999
    ..The subsequent corrected P values do not depend on finding this warping; it is sufficient only to know that such a warping exists...
  80. ncbi The topography of white matter hyperintensities on brain MRI in healthy 60- to 64-year-old individuals
    Wei Wen
    Neuropsychiatric Institute, Prince of Wales Hospital, School of Psychiatry, University of New South Wales, Randwick 2031, Sydney, Australia
    Neuroimage 22:144-54. 2004
    ..This study provides the first detailed topographic analysis of WMHs in a large representative middle-aged sample, emphasizes their high prevalence in mid-adult life and raises issues about their etiology and significance...
  81. ncbi The effects of aging upon the hemodynamic response measured by functional MRI
    S A Huettel
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Neuroimage 13:161-75. 2001
    ..Recovery measures were similar across the age groups...
  82. ncbi Optimisation of the 3D MDEFT sequence for anatomical brain imaging: technical implications at 1.5 and 3 T
    R Deichmann
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Neuroimage 21:757-67. 2004
    ..It is shown both theoretically and experimentally that these problems can be avoided by using spin tagging and fat saturation...
  83. ncbi Cerebral cortex thickness in 15-year-old adolescents with low birth weight measured by an automated MRI-based method
    M Martinussen
    Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Brain 128:2588-96. 2005
    ....
  84. ncbi Current methods in medical image segmentation
    D L Pham
    Department of Electrical and Computer Engineering, Johns Hopkins University, Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland, USA
    Annu Rev Biomed Eng 2:315-37. 2000
    ..We conclude with a discussion on the future of image segmentation methods in biomedical research...
  85. ncbi The neuropsychiatry of Niemann-Pick type C disease in adulthood
    Mark Walterfang
    Neuropsychiatry Unit, Level 2, John Cade Building, Royal Melbourne Hospital, Melbourne 3050, Australia
    J Neuropsychiatry Clin Neurosci 18:158-70. 2006
    ....
  86. ncbi Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 60:1250-8. 2006
    ..This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC). Studies in animals have suggested that the relationship between these brain regions is strongly modulated by dopamine...
  87. pmc Functional neural networks underlying response inhibition in adolescents and adults
    Michael C Stevens
    Olin Neuropsychiatry Research Center, Hartford, CT 06106, United
    Behav Brain Res 181:12-22. 2007
    ..We identify and characterize several age-related differences in the function of neural circuits that are associated with behavioral performance changes across adolescent development...
  88. ncbi Co-activation of the amygdala, hippocampus and inferior frontal gyrus during autobiographical memory retrieval
    Daniel L Greenberg
    Psychological and Brain Sciences, Duke University, Durham, NC 27708 0999, USA
    Neuropsychologia 43:659-74. 2005
    ..These results support theories of autobiographical memory that hypothesize co-activation of frontotemporal areas during recollection of episodes from the personal past...
  89. ncbi Diffusion-weighted MR imaging in monitoring the effect of a vascular targeting agent on rhabdomyosarcoma in rats
    Harriet C Thoeny
    Department of Radiology, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Radiology 234:756-64. 2005
    ..To evaluate diffusion-weighted magnetic resonance (MR) imaging for monitoring tumor response in rats after administration of combretastatin A4 phosphate...
  90. ncbi IMIRS: a high-resolution 3D reconstruction package integrated with a relational image database
    Yuyao Liang
    Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, 77030, USA
    J Struct Biol 137:292-304. 2002
    ..We demonstrate the applicability of IMIRS in icosahedral reconstruction toward high resolution by using it to obtain an 8-A 3D structure of an intermediate-sized dsRNA virus...
  91. pmc Probabilistic anatomical connectivity derived from the microscopic persistent angular structure of cerebral tissue
    Geoffrey J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Philos Trans R Soc Lond B Biol Sci 360:893-902. 2005
    ..Using the extracted PAS in probabilistic fibre tracking allows higher specificity and sensitivity than previously reported fibre tracking using diffusion-weighted MRI in the corticospinal tract...
  92. ncbi Cognitive performance in schizophrenia: relationship to regional brain volumes and psychiatric symptoms
    Michael Sanfilipo
    Mental Health Service, New York Veterans Affairs Medical Center, New York, NY, USA
    Psychiatry Res 116:1-23. 2002
    ....
  93. ncbi Neural substrates of spoken language rehabilitation in an aphasic patient: an fMRI study
    A Leger
    INSERM U 455 and Department of Neurology, CHU Purpan, Toulouse, France
    Neuroimage 17:174-83. 2002
    ..Speech therapy effect was associated with activations in Broca's area and the left supra-marginal gyrus, which might reflect a therapy-induced phonological compensatory strategy for naming...
  94. ncbi The neural mechanisms underlying the influence of pavlovian cues on human decision making
    Signe Bray
    Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    J Neurosci 28:5861-6. 2008
    ..The results of this study are relevant for understanding how marketing actions can affect consumer choice behavior as well as for how environmental cues can influence drug-seeking behavior in addiction...
  95. ncbi Fluorescence molecular tomography resolves protease activity in vivo
    Vasilis Ntziachristos
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Nat Med 8:757-60. 2002
    ....
  96. ncbi Voxel-based morphometric comparison of hippocampal and extrahippocampal abnormalities in patients with left and right hippocampal atrophy
    Simon S Keller
    The Magnetic Resonance and Image Analysis Research Centre MARIARC, United Kingdom
    Neuroimage 16:23-31. 2002
    ....
  97. ncbi EZ-Rhizo: integrated software for the fast and accurate measurement of root system architecture
    Patrick Armengaud
    Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Plant J 57:945-56. 2009
    ..We have successfully applied EZ-Rhizo to evaluate natural variation in RSA across 23 Arabidopsis thaliana accessions, and have identified new RSA determinants as a basis for future quantitative trait locus (QTL) analysis...
  98. ncbi Statistical neuroanatomy of the human inferior frontal gyrus and probabilistic atlas in a standard stereotaxic space
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK
    Hum Brain Mapp 28:34-48. 2007
    ..Applications include probabilistic determination of location in group studies, automatic labeling of new scans, and detection of anatomical abnormalities in patients...
  99. ncbi Diffusion tensor imaging of time-dependent axonal and myelin degradation after corpus callosotomy in epilepsy patients
    Luis Concha
    Department of Biomedical Engineering, Faculty of Medicine and Dentistry, 1098 Research Transition Facility, University of Alberta, Edmonton, Alberta, Canada T6G 2V2
    Neuroimage 32:1090-9. 2006
    ..DTI is capable of non-invasively detecting, staging and following the microstructural degradation of white matter following axonal injury...
  100. pmc A fuzzy locally adaptive Bayesian segmentation approach for volume determination in PET
    Mathieu Hatt
    LATIM, INSERM, U650, 29609 Brest, France
    IEEE Trans Med Imaging 28:881-93. 2009
    ....
  101. ncbi Digitizing life at the level of the cell: high-performance laser-scanning microscopy and image analysis for in toto imaging of development
    Sean G Megason
    Biological Imaging Center, Beckman Institute and Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mech Dev 120:1407-20. 2003
    ..There are significant challenges that must be met to reach these goals. This paper will discuss the current state-of-the-art, the challenges, and the prospects of in toto imaging in the areas of imaging, image analysis, and informatics...

Research Grants62

  1. Host factors involved in Listeria monocytogenes spread from cell to cell
    HERVE F AGAISSE; Fiscal Year: 2010
    ..abstract_text> ..
  2. Molecular Imaging for Macrophage-Associated Pulmonary Inflammation
    Sanjay Jain; Fiscal Year: 2013
    ..All tools developed in this proposal are directly translatable to humans, and will be applicable broadly to other macrophage-associated pulmonary infectious or inflammatory conditions. (End of Abstract) ..
  3. Regulation of bacterial pathogen actin-based motility by host cell kinases
    HERVE F AGAISSE; Fiscal Year: 2012
    ..The proposed approach will contribute to our general understanding of the mechanisms underlying microbial pathogenesis and may therefore constitute the foundation for the rational design of preventive and therapeutic interventions. ..
  4. Inactivation of hyperpermeability after ischemia-reperfusion induced inflammation
    Walter N Duran; Fiscal Year: 2012
    ..Our results should be of clinical relevance to revascularization in elective and emergency vascular surgery. ..
  5. Genotype and phenotype predictors in therapy response in renal cell carcinoma
    Katherine L Nathanson; Fiscal Year: 2013
    ..abstract_text> ..
  6. CONTROL OF MICROCIRCULATORY EXCHANGE FUNCTION
    Walter N Duran; Fiscal Year: 2012
    ..We will apply intravital microscopy in conjunction with computer-assisted image analysis and molecular biology approaches to elucidate the postulated mechanisms. ..
  7. NOVEL APPROACHES TO RADIO-IMMUNOCONJUGATE DOSIMETRY
    Lee Chin; Fiscal Year: 1991
    ..The dosimetric tools developed here will be appropriate for later application to clinical radio-immunotherapy...
  8. Estrogen and brain vascular inflammation in diabetics
    Dale Pelligrino; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  9. CEREBRAL ISCHEMIA--MINIMIZING DAMAGE DURING ANESTHESIA
    David Warner; Fiscal Year: 1992
    ..The proposed studies will contribute to our understanding of these problems...
  10. LONG MUSCLES WITH SERIES FIBERS--ULTASTRUCTURE
    John Trotter; Fiscal Year: 1991
    ..The results should significantly enhance our understanding of an important aspect of muscle biology which has heretofore been overlooked...
  11. THALAMIC PLASTICITY INDUCED BY LESIONS IN BASAL GANGLIA
    HELI KRISTY KULTAS ILINSKY; Fiscal Year: 1990
    ....
  12. VOLITIONAL, BOLUS, AND AGE EFFECTS ON HUMAN SWALLOWING
    Peter Kahrilas; Fiscal Year: 2000
    ..The analysis tool of the 3-dimensional graphics program can quantify instantaneous intrapharyngeal volume, which coupled with pressure data from the pharyngeal outlet, may yield a useful parameter of swallow efficacy. ..
  13. Whole Slide Imaging System for Tissue Services Core
    Charles Handorf; Fiscal Year: 2009
    ....
  14. CONNECTIONS IN ADULT AND DEVELOPING SOMATOSENSORY CORTEX
    KERRY BERNARDO; Fiscal Year: 1990
    ..This computer-assisted analysis of cortical connectional patterns in normal and experimentally manipulated animals will provide insight into the organization, development and maintenance of intracortical connections...
  15. SYMPATHETIC AND PEPTIDERGIC CONTROL OF COLON MOTILITY
    JEAN JEW; Fiscal Year: 1990
    ..This will strengthen and expand physiological and pharmacological opportunities to solve problems in both normal and pathological gastroenterology...
  16. ROLE OF THE NEUROLOGIC SYSTEM IN CUTANEOUS ANGIOGENESIS
    JOHN ANSEL; Fiscal Year: 2004
    ..These studies will further basic understanding of the role of the nervous system in angiogenesis and could lead to novel therapies for a wide range of cutaneous processes including inflammation, wound healing, and neoplasia. ..
  17. Proteomics of Biliary Atresia
    Robert Heuckeroth; Fiscal Year: 2005
    ....
  18. CAP-PAP TEST FOR CERVICAL CANCER SCREENING
    Olivera Markovic; Fiscal Year: 2000
    ..PROPOSED COMMERCIAL APPLICATIONS: If approved as a diagnostic medical device,the test will face a market of 100 millions requests per year. ..
  19. HELI-KRISTCONNECTIONS OF THE MOTOR THALAMUS
    HELI KRISTY KULTAS ILINSKY; Fiscal Year: 1990
    ..The use of this surgical technique together with a recently constructed stereotactic atlas of monkey brain that also utilizes the intracerebral coordinate system ensures the success of the proposed experiments...
  20. Site-Specific Immune Control in the CNS
    LOIS LAMPSON; Fiscal Year: 2005
    ..Methods include intra-cerebral injection of cytokine (IFN-gamma) and pharmacological agents (SP, agonists, antagonists), antibody staining of tissue sections, and computer-assisted image analysis. Rats are used. ..
  21. LOCAL CONTROL OF IMMUNE ACTIVITY IN THE BRAIN
    LOIS LAMPSON; Fiscal Year: 2001
    ..Methods include stereotactic injection, antibody staining of cryostat sections, and computer-assisted image analysis. Rats are used. ..
  22. Image Reconstruction with Solid Srate SPECR
    LAWRENCE ZENG; Fiscal Year: 2005
    ..abstract_text> ..
  23. Mouse Modeling Techniques for Bioluminescence Tomography
    Wenxiang Cong; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  24. Deep ultraviolet nonlinear microscopy in thick tissue
    Jerome Mertz; Fiscal Year: 2006
    ..Ultimately, we hope to confirm our hypothesis that intrinsic optical signals in the DUV spectral window, which has largely been overlooked so far, can provide useful and clinically relevant information. ..
  25. Data Consistency Based Motion Artifact Reduction for Head CT
    Hengyong Yu; Fiscal Year: 2008
    ..Hence, the proposed techniques promise to be translated for clinical use and should generate great healthcare benefits, especially for children. [unreadable] [unreadable] [unreadable]..
  26. Thick tissue imaging with auto-confocal microscopy
    Jerome Mertz; Fiscal Year: 2004
    ..abstract_text> ..
  27. Breast Cancer Imaging Using a Solid-State SPECT Camera
    G Zeng; Fiscal Year: 2005
    ..abstract_text> ..
  28. Neuroimaging and Functional Senscence in Aging
    Nikolaos Makris; Fiscal Year: 2002
    ..abstract_text> ..
  29. Radio-Immunotherapy (RIT) Planning Using SPECT
    LAWRENCE ZENG; Fiscal Year: 2004
    ..Novel image reconstruction algorithms will be developed to provided quantitative SPECT images. Our hypothesis will be verified through human observer studies and Channelized Hotelling observer studies. ..
  30. Widefield fluorescence macroscopy with out-of-focus blur rejection
    Jerome Mertz; Fiscal Year: 2008
    ..Our goal is to build a new tool for cancer research that can eventually be implemented in the clinic. [unreadable] [unreadable] [unreadable]..
  31. AGE-RELATED CHANGES IN MONKEY CORTICAL PYRAMIDAL CELLS
    Jennifer Luebke; Fiscal Year: 2009
    ..Such information is vital to the development of a detailed understanding of the cellular mechanisms of cognitive decline, and a prerequisite for the future development of therapeutic interventions. ..
  32. 3D Massive Training ANN for CAD for Colon Cancer in CT Colonography
    Kenji Suzuki; Fiscal Year: 2010
    ....
  33. RETROSPECTIVE IMAGE REGISTRATION EVALUATION
    J Fitzpatrick; Fiscal Year: 2003
    ..The objective assessment provided by this project should foster improvement of the accuracy of retrospective registration techniques. ..
  34. Treatment of lung cancer
    Derick Lau; Fiscal Year: 2008
    ..The long-term goal is to develop these peptide ligands as molecularly targeted therapy for lung cancer. 4. To recruit and train hematology and oncology specialists in clinical research of cancer therapy. ..
  35. BRAILLE READING & ADAPTIVE PLASTICITY IN THE HUMAN BRAIN
    Harold Burton; Fiscal Year: 2009
    ..In all experiments blood oxygen level dependent response dynamics in visual and selective non-visual areas will be quantitatively analyzed and correlated with performance to determine likely causal relationships. ..
  36. PREVENTION OF GERATRIC DEPRESSION
    George Alexopoulos; Fiscal Year: 2003
    ..Accordingly, we are well positioned to meet the challenges inherent in this difficult but important area of research. ..
  37. Neural Dissection of Hyperactivity/Inattention in Autism
    Francisco Xavier Castellanos; Fiscal Year: 2010
    ..If successful, we will be able to better understand the types of brain mechanisms that are involved in hyperactivity and inattention in children with autism and then be able to use that information to guide targeted treatment studies. ..
  38. Structural MRI of trabecular bone for therapy response monitoring
    Felix Wehrli; Fiscal Year: 2009
    ..Already established Penn-internal partnerships with Dr. Charles Epstein (Department of Mathematics) and Dr. Peter Snyder (Department of Medicine, Division of Endocrinology) will be further expanded and strengthened. ..
  39. Temporal Clustering Analysis for Detection of Irregular Transient fMRI Activation
    VICTORIA MORGAN; Fiscal Year: 2009
    ....
  40. Hemodynamic and Cognitive Function in Cardiovascular Disease
    Lawrence H Sweet; Fiscal Year: 2011
    ..Findings are expected to provide data and methods that will increase the clinical utility of FMRI for the assessment of CVD patients, and a better understanding of the mechanisms causing cognitive impairment. ..
  41. FUNCTIONAL MRI OF HUMAN BRAIN LANGUAGE SYSTEMS
    Jeffrey R Binder; Fiscal Year: 2010
    ..abstract_text> ..
  42. CT DEVICE FOR MICROIMAGING OF TISSUE SPECIMENS IN VIVO
    Felix Wehrli; Fiscal Year: 2001
    ..abstract_text> ..
  43. MONTE CARLO SIMULATION OF HIGH ENERGY PHOTON IMAGING
    Yuni Dewaraja; Fiscal Year: 2001
    ..Apart from quantification, this work will have applications in the design of future imaging systems for high energy photons. ..
  44. Neural Substrates of Variability in Attention Deficit Hyperactivity Disorder (ADH
    Francisco Xavier Castellanos; Fiscal Year: 2010
    ..Achieving such a level of detailed information about brain functioning in ADHD would have major impact on our ability to improve methods of diagnosing ADHD and of developing new treatments. ..
  45. 2008 Summer Bioengineering Conference
    Baruch Lieber; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  46. EFFECTS OF LESIONS ON VISUAL MOTION PERCEPTION IN HUMANS
    LUCIA VAINA; Fiscal Year: 2005
    ....
  47. Structure-Function Assessment of Carotid Disease by MR
    Felix Wehrli; Fiscal Year: 2004
    ....
  48. QUANTITATIVE CARDIAC PHYSIOLOGY IN CLINICAL CARDIOLOGY
    Sandor Kovacs; Fiscal Year: 2004
    ..abstract_text> ..
  49. Treatment Outcome of Vascular Depression
    Yvette Sheline; Fiscal Year: 2005
    ..The proposed trial will provide information of value to the practitioner and also provide data to build a more comprehensive model of the prognostic impact of frontal-subcortical brain changes on the outcome of late-life depression. ..
  50. Adolescent Alcohol Abuse, PTSD & Hippocampal Development
    MICHAEL DE BELLIS; Fiscal Year: 2003
    ..In addition to examining the differences among these groups, the effects of AUD age of onset, AUD severity, as well as alcohol consumption quantity, frequency, and duration, on adolescent hippocampal development will also be examined. ..
  51. Neuroimaging in Depression Treatment Studies
    Yvette Sheline; Fiscal Year: 2006
    ..abstract_text> ..
  52. NEUROGENETICS, SEROTONIN, AND HUMAN AGGRESSION
    STEPHEN MANUCK; Fiscal Year: 2003
    ..This application is the resubmission of a prior proposal of the same title. ..
  53. BIOSTATISTICAL METHODS FOR HUMAN BRAIN MAPPING
    Nicholas Lange; Fiscal Year: 2006
    ..abstract_text> ..
  54. VOLUMETRIC MR MOLECULAR IMAGING OF BRAIN
    ANDREW MAUDSLEY; Fiscal Year: 2006
    ..Matson). This development will establish the range and variance of normal metabolite profiles and provide valuable comparative data for numerous clinical investigations that use short-TE 1H MRS. [unreadable] [unreadable]..
  55. AUTOMATIC CORRECTION OF MOTION ARTIFACTS IN MR IMAGES
    Armando Manduca; Fiscal Year: 2007
    ..They represent perhaps the most flexible and universally applicable techniques for the correction of motion (and other) artifacts in MR imaging. ..
  56. Prefrontal Neuronal Responses During Extinction of Fear
    Mohammed Milad; Fiscal Year: 2003
    ..This proposed study will bring us closer to understanding the mechanisms of fear extinction. Facilitation of extinction processes in patients with disorders such as PTSD could potentially help in curing such disorders. ..
  57. Imaging CMRO2 with combined DOT and MRI
    David Boas; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  58. Structural-functional MRI Studies of Memory in MCI & AD
    Bradford Dickerson; Fiscal Year: 2007
    ..abstract_text> ..
  59. Subharmonic Microbubble Signals for Pressure Estimation
    Flemming Forsberg; Fiscal Year: 2008
    ..This will allow potentially life-threatening diseases, such as increased pressure in the liver, to be diagnosed early. [unreadable] [unreadable] [unreadable]..
  60. Probabilistic Modeling of Information from Images and Text in Online Journals
    Robert Murphy; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  61. BOLD fMRI in MR research to map learning histories
    MICHAEL SCHLUND; Fiscal Year: 2004
    ..abstract_text> ..