speech

Summary

Summary: Communication through a system of conventional vocal symbols.

Top Publications

  1. pmc Selective cortical representation of attended speaker in multi-talker speech perception
    Nima Mesgarani
    Departments of Neurological Surgery and Physiology, UCSF Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
    Nature 485:233-6. 2012
  2. pmc A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading
    Cathy J Price
    Wellcome Trust Centre for Neuroimaging, UCL, London WC1N 3BG, UK
    Neuroimage 62:816-47. 2012
  3. ncbi A theory of lexical access in speech production
    W J Levelt
    Max Planck Institute for Psycholinguistics, 6500 AH Nijmegen, The Netherlands www mpi nl
    Behav Brain Sci 22:1-38; discussion 38-75. 1999
  4. doi The anatomy of language: a review of 100 fMRI studies published in 2009
    Cathy J Price
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Ann N Y Acad Sci 1191:62-88. 2010
  5. ncbi Evidence from functional magnetic resonance imaging of crossmodal binding in the human heteromodal cortex
    G A Calvert
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford, UK
    Curr Biol 10:649-57. 2000
  6. pmc Cortical oscillations and speech processing: emerging computational principles and operations
    Anne Lise Giraud
    INSERM U960, Departement d Etudes Cognitives, Ecole Normale Superieure, Paris, France
    Nat Neurosci 15:511-7. 2012
  7. doi FOXP2 as a molecular window into speech and language
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Genet 25:166-77. 2009
  8. doi Computational neuroanatomy of speech production
    Gregory Hickok
    Department of Cognitive Sciences, University of California, Irvine, California 92697, USA
    Nat Rev Neurosci 13:135-45. 2012
  9. doi Transitions in neural oscillations reflect prediction errors generated in audiovisual speech
    Luc H Arnal
    Inserm U960 École Normale Supérieure, Paris, France
    Nat Neurosci 14:797-801. 2011
  10. pmc Neural modeling and imaging of the cortical interactions underlying syllable production
    Frank H Guenther
    Department of Cognitive and Neural Systems, Boston University, 677 Beacon Street Boston, MA 02215, USA
    Brain Lang 96:280-301. 2006

Research Grants

  1. HEART RATE ACTIVITY AND INFANT SPEECH PERCEPTION
    ROBIN PANNETON; Fiscal Year: 2002
  2. NEUROMOTOR BASIS OF STUTTERING
    MICHAEL MCCLEAN; Fiscal Year: 2003
  3. Linguapalatal Contact Pressures During Speech
    JEFFREY SEARL; Fiscal Year: 2003
  4. Effects of sensorineural loss on robust speech coding
    Michael Heinz; Fiscal Year: 2007
  5. User Adaptation of AAC Device Voices
    JAN VAN SANTEN; Fiscal Year: 2007
  6. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
  7. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
  8. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
  9. Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity
    Vickram Ramkumar; Fiscal Year: 2013
  10. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010

Detail Information

Publications379 found, 100 shown here

  1. pmc Selective cortical representation of attended speaker in multi-talker speech perception
    Nima Mesgarani
    Departments of Neurological Surgery and Physiology, UCSF Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
    Nature 485:233-6. 2012
    ..How the auditory system manages to extract intelligible speech under such acoustically complex and adverse listening conditions is not known, and, indeed, it is not clear how ..
  2. pmc A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading
    Cathy J Price
    Wellcome Trust Centre for Neuroimaging, UCL, London WC1N 3BG, UK
    Neuroimage 62:816-47. 2012
    ..Here I attempt to provide an overview of the brain areas associated with heard speech, speech production and reading...
  3. ncbi A theory of lexical access in speech production
    W J Levelt
    Max Planck Institute for Psycholinguistics, 6500 AH Nijmegen, The Netherlands www mpi nl
    Behav Brain Sci 22:1-38; discussion 38-75. 1999
    Preparing words in speech production is normally a fast and accurate process...
  4. doi The anatomy of language: a review of 100 fMRI studies published in 2009
    Cathy J Price
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Ann N Y Acad Sci 1191:62-88. 2010
    In this review of 100 fMRI studies of speech comprehension and production, published in 2009, activation is reported for: prelexical speech perception in bilateral superior temporal gyri; meaningful speech in middle and inferior temporal ..
  5. ncbi Evidence from functional magnetic resonance imaging of crossmodal binding in the human heteromodal cortex
    G A Calvert
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford, UK
    Curr Biol 10:649-57. 2000
    ..Although spatially concordant multisensory inputs can produce a dramatic, often multiplicative, increase in cellular activity, spatially disparate cues tend to induce a profound response depression...
  6. pmc Cortical oscillations and speech processing: emerging computational principles and operations
    Anne Lise Giraud
    INSERM U960, Departement d Etudes Cognitives, Ecole Normale Superieure, Paris, France
    Nat Neurosci 15:511-7. 2012
    ..delta, theta and gamma oscillations are specifically engaged by the multi-timescale, quasi-rhythmic properties of speech and can track its dynamics...
  7. doi FOXP2 as a molecular window into speech and language
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK
    Trends Genet 25:166-77. 2009
    Rare mutations of the FOXP2 transcription factor gene cause a monogenic syndrome characterized by impaired speech development and linguistic deficits...
  8. doi Computational neuroanatomy of speech production
    Gregory Hickok
    Department of Cognitive Sciences, University of California, Irvine, California 92697, USA
    Nat Rev Neurosci 13:135-45. 2012
    b>Speech production has been studied predominantly from within two traditions, psycholinguistics and motor control...
  9. doi Transitions in neural oscillations reflect prediction errors generated in audiovisual speech
    Luc H Arnal
    Inserm U960 École Normale Supérieure, Paris, France
    Nat Neurosci 14:797-801. 2011
    ..When visual speech input correctly predicted auditory speech signals, a slow delta regime (3-4 Hz) developed in higher-order speech ..
  10. pmc Neural modeling and imaging of the cortical interactions underlying syllable production
    Frank H Guenther
    Department of Cognitive and Neural Systems, Boston University, 677 Beacon Street Boston, MA 02215, USA
    Brain Lang 96:280-301. 2006
    This paper describes a neural model of speech acquisition and production that accounts for a wide range of acoustic, kinematic, and neuroimaging data concerning the control of speech movements...
  11. ncbi Temporal window of integration in auditory-visual speech perception
    Virginie van Wassenhove
    Department of Psychology, University of California at Los Angeles, CA 90095, USA
    Neuropsychologia 45:598-607. 2007
    ..hearing participants were tested in two experiments, which focused on temporal coincidence in auditory visual (AV) speech perception...
  12. ncbi Molecular evolution of FOXP2, a gene involved in speech and language
    Wolfgang Enard
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Nature 418:869-72. 2002
    ..The ability to develop articulate speech relies on capabilities, such as fine control of the larynx and mouth, that are absent in chimpanzees and other ..
  13. doi Interactions between auditory and visual semantic stimulus classes: evidence for common processing networks for speech and body actions
    Georg F Meyer
    School of Psychology, Liverpool University, Eleanor Rathbone Building, Liverpool, United Kingdom
    J Cogn Neurosci 23:2291-308. 2011
    ..To address this question, we explore the effect of semantic congruency within and across three signal categories (speech, body actions, and unfamiliar patterns) for signals with matched low-level statistics...
  14. doi "Who" is saying "what"? Brain-based decoding of human voice and speech
    Elia Formisano
    Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, University of Maastricht, 6200 MD Maastricht, Netherlands
    Science 322:970-3. 2008
    Can we decipher speech content ("what" is being said) and speaker identity ("who" is saying it) from observations of brain activity of a listener? Here, we combine functional magnetic resonance imaging with a data-mining algorithm and ..
  15. doi Similar cerebral networks in language, music and song perception
    Daniele Schon
    Mediterranean Institute of Cognitive Neurosciences, CNRS and Aix Marseille University, and fMRI Centre, Timone Hospital, Marseille, France
    Neuroimage 51:450-61. 2010
    ..Taken together, results of both experiments argue against domain specificity and provide additional evidence for a common cerebral network involved in both lexical/phonological and melodic processing...
  16. pmc Error-dependent modulation of speech-induced auditory suppression for pitch-shifted voice feedback
    Roozbeh Behroozmand
    Speech Physiology Laboratory, Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208, USA
    BMC Neurosci 12:54. 2011
    ....
  17. doi Twice upon a time: multiple concurrent temporal recalibrations of audiovisual speech
    Warrick Roseboom
    The University of Queensland, School of Psychology, Brisbane, Queensland, Australia
    Psychol Sci 22:872-7. 2011
    ..Our results show that humans can form multiple concurrent estimates of appropriate timing for audiovisual synchrony...
  18. ncbi A new brain region for coordinating speech articulation
    N F Dronkers
    VA Northern California Health Care System, Martinez, California 94553, USA
    Nature 384:159-61. 1996
    Human speech requires complex planning and coordination of mouth and tongue movements...
  19. doi Twitter evolution: converging mechanisms in birdsong and human speech
    Johan J Bolhuis
    Behavioural Biology, Department of Biology and Helmholtz Institute, Utrecht University, Padualaan 8, Utrecht, The Netherlands
    Nat Rev Neurosci 11:747-59. 2010
    ....
  20. ncbi Efficient auditory coding
    Evan C Smith
    Department of Psychology, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nature 439:978-82. 2006
    ..We find that when the features are optimized for coding either natural sounds or speech, they show striking similarities to time-domain cochlear filter estimates, have a frequency-bandwidth dependence ..
  21. pmc Magnetoencephalographic evidence for a precise forward model in speech production
    Theda H Heinks-Maldonado
    Department of Otolaryngology, University of California, San Francisco, California 94143, USA
    Neuroreport 17:1375-9. 2006
    ..and magnetoencephalography studies have shown that auditory cortical responses to self-produced speech are attenuated when compared with responses to tape-recorded speech, but that this attenuation disappears if ..
  22. ncbi Listening to speech activates motor areas involved in speech production
    Stephen M Wilson
    Ahmanson Lovelace Brain Mapping Center and Neuroscience Interdepartmental Program, University of California, Los Angeles, California 90095, USA
    Nat Neurosci 7:701-2. 2004
    To examine the role of motor areas in speech perception, we carried out a functional magnetic resonance imaging (fMRI) study in which subjects listened passively to monosyllables and produced the same speech sounds...
  23. pmc Musicians have enhanced subcortical auditory and audiovisual processing of speech and music
    Gabriella Musacchia
    Auditory Neuroscience Laboratory, Department of Communication Sciences, Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 104:15894-8. 2007
    ..Here, we show that such modifications extend to subcortical sensory structures and generalize to processing of speech. Musicians had earlier and larger brainstem responses than nonmusician controls to both speech and music stimuli ..
  24. pmc Dopamine regulation of human speech and bird song: a critical review
    Kristina Simonyan
    Department of Neurology, Mount Sinai School of Medicine, New York, NY, United States
    Brain Lang 122:142-50. 2012
    To understand the neural basis of human speech control, extensive research has been done using a variety of methodologies in a range of experimental models...
  25. pmc The anatomy of language: contributions from functional neuroimaging
    C J Price
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK
    J Anat 197:335-59. 2000
    ..system, is shown to be part of a distributed semantic system that can be accessed by objects and faces as well as speech. Other components of the semantic system include several regions in the inferior and middle temporal lobes...
  26. pmc Temporal predictive codes for spoken words in auditory cortex
    Pierre Gagnepain
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Curr Biol 22:615-21. 2012
    ..a single word is selected ("formula" inhibits "formal" by lexical competition) or (2) are used to predict upcoming speech sounds more accurately (segment prediction error is minimal after sequences like "formu…")...
  27. pmc Speech-induced striatal dopamine release is left lateralized and coupled to functional striatal circuits in healthy humans: a combined PET, fMRI and DTI study
    Kristina Simonyan
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroimage 70:21-32. 2013
    Considerable progress has been recently made in understanding the brain mechanisms underlying speech and language control. However, the neurochemical underpinnings of normal speech production remain largely unknown...
  28. ncbi Cortical interactions underlying the production of speech sounds
    Frank H Guenther
    Department of Cognitive and Neural Systems, Boston University, 677 Beacon Street, Boston, MA 02215, USA
    J Commun Disord 39:350-65. 2006
    b>Speech production involves the integration of auditory, somatosensory, and motor information in the brain...
  29. ncbi Phonotactic cues for segmentation of fluent speech by infants
    S L Mattys
    Department of Psychology, Johns Hopkins University, MD, Baltimore, USA
    Cognition 78:91-121. 2001
    ..The present study investigates whether 9-month-olds make use of phonotactic cues to segment words from fluent speech. Using the Headturn Preference Procedure, we found that infants listened to a CVC stimulus longer when the ..
  30. pmc Laryngeal motor cortex and control of speech in humans
    Kristina Simonyan
    Departments of Neurology and Otolaryngology, Mount Sinai School of Medicine, New York, NY, USA
    Neuroscientist 17:197-208. 2011
    b>Speech production is one of the most complex and rapid motor behaviors, and it involves a precise coordination of more than 100 laryngeal, orofacial, and respiratory muscles...
  31. ncbi Early language acquisition: cracking the speech code
    Patricia K Kuhl
    Institute for Learning and Brain Sciences and the Department of Speech and Hearing Sciences, University of Washington, Seattle, Washington 98195, USA
    Nat Rev Neurosci 5:831-43. 2004
    ..Social interaction with another human being affects speech learning in a way that resembles communicative learning in songbirds...
  32. doi Speaking to the trained ear: musical expertise enhances the recognition of emotions in speech prosody
    Cesar F Lima
    Faculty of Psychology and Education, University of Porto, Rua Doutor Alfredo Allen, 4200 135 Porto, Portugal
    Emotion 11:1021-31. 2011
    Language and music are closely related in our minds. Does musical expertise enhance the recognition of emotions in speech prosody? Forty highly trained musicians were compared with 40 musically untrained adults (controls) in the ..
  33. ncbi When language meets action: the neural integration of gesture and speech
    Roel M Willems
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands
    Cereb Cortex 17:2322-33. 2007
    ..Here we investigated one particular form of simultaneous language and action, namely speech and gestures that speakers use in everyday communication...
  34. doi Integration of iconic gestures and speech in left superior temporal areas boosts speech comprehension under adverse listening conditions
    Henning Holle
    University of Sussex, Department of Psychology, Falmer, Brighton, UK
    Neuroimage 49:875-84. 2010
    Iconic gestures are spontaneous hand movements that illustrate certain contents of speech and, as such, are an important part of face-to-face communication...
  35. doi Neural interaction of speech and gesture: differential activations of metaphoric co-verbal gestures
    Tilo Kircher
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstr 30, D 52074 Aachen, Germany
    Neuropsychologia 47:169-79. 2009
    ..However, little is known about the neural correlates of gestures accompanying speech comprehension...
  36. pmc Co-speech gestures influence neural activity in brain regions associated with processing semantic information
    Anthony Steven Dick
    Department of Neurology, The University of Chicago, Chicago, Illinois 60637, USA
    Hum Brain Mapp 30:3509-26. 2009
    Everyday communication is accompanied by visual information from several sources, including co-speech gestures, which provide semantic information listeners use to help disambiguate the speaker's message...
  37. pmc The neonate brain detects speech structure
    Judit Gervain
    Cognitive Neuroscience Sector, Scuola Internazionale Superiore di Studi Avanzati, 34014 Trieste, Italy
    Proc Natl Acad Sci U S A 105:14222-7. 2008
    ..in life? Although previous studies have identified different mechanisms underlying the acquisition of auditory and speech patterns in older infants and adults, the earliest sensitivities remain unexplored...
  38. pmc Functional overlap between regions involved in speech perception and in monitoring one's own voice during speech production
    Zane Z Zheng
    Centre for Neuroscience Studies, Queen s University, Ontario, Canada
    J Cogn Neurosci 22:1770-81. 2010
    The fluency and the reliability of speech production suggest a mechanism that links motor commands and sensory feedback...
  39. pmc Speech facilitation by left inferior frontal cortex stimulation
    Rachel Holland
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
    Curr Biol 21:1403-7. 2011
    ....
  40. pmc The time course of word retrieval revealed by event-related brain potentials during overt speech
    Albert Costa
    Department de Tecnologia, Institucio Catalana de Recerca i Estudis Avancats, Universitat Pompeu Fabra, 08018 Barcelona, Cataluña, Spain
    Proc Natl Acad Sci U S A 106:21442-6. 2009
    b>Speech production is one of the most fundamental activities of humans. A core cognitive operation involved in this skill is the retrieval of words from long-term memory, that is, from the mental lexicon...
  41. pmc Neural mechanisms underlying auditory feedback control of speech
    Jason A Tourville
    Department of Cognitive and Neural Systems, Boston University, 677 Beacon St, Boston, MA 02215, USA
    Neuroimage 39:1429-43. 2008
    The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling...
  42. ncbi Neural correlates of verbal feedback processing: an fMRI study employing overt speech
    Ingrid K Christoffels
    Department of Cognitive Neuroscience, Faculty of Psychology, Maastricht University, The Netherlands
    Hum Brain Mapp 28:868-79. 2007
    Speakers use external auditory feedback to monitor their own speech. Feedback distortion has been found to increase activity in the superior temporal areas...
  43. pmc Motor cortex maps articulatory features of speech sounds
    Friedemann Pulvermüller
    Cognition and Brain Sciences Unit, Medical Research Council, 15 Chaucer Road, Cambridge CB2 2EF, United Kingdom
    Proc Natl Acad Sci U S A 103:7865-70. 2006
    The processing of spoken language has been attributed to areas in the superior temporal lobe, where speech stimuli elicit the greatest activation...
  44. doi Perceptual systems controlling speech production
    Novraj S Dhanjal
    Division of Neuroscience and Mental Health and Medical Research Council Clinical Sciences Centre, Imperial College London, London W12 0NN, United Kingdom
    J Neurosci 28:9969-75. 2008
    It is proposed that the acquisition and maintenance of fluent speech depend on the rapid temporal integration of motor feedforward and polysensory (auditory and somatosensory) feedback signals...
  45. pmc A little more conversation, a little less action--candidate roles for the motor cortex in speech perception
    Sophie K Scott
    Institute for Cognitive Neuroscience, University College London, 17 Queen Square, London, UK
    Nat Rev Neurosci 10:295-302. 2009
    The motor theory of speech perception assumes that activation of the motor system is essential in the perception of speech...
  46. doi Decoding the genetics of speech and language
    Sarah A Graham
    Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands
    Curr Opin Neurobiol 23:43-51. 2013
    ..example, rare protein-coding mutations of the FOXP2 transcription factor cause severe problems with sequencing of speech sounds, while common genetic risk variants of small effect size in genes like CNTNAP2, ATP2C2 and CMIP are ..
  47. doi The varieties of inner speech: links between quality of inner speech and psychopathological variables in a sample of young adults
    Simon McCarthy-Jones
    Department of Psychology, Durham University, South Road, Durham DH1 3LE, UK
    Conscious Cogn 20:1586-93. 2011
    A resurgence of interest in inner speech as a core feature of human experience has not yet coincided with methodological progress in the empirical study of the phenomenon...
  48. doi Auditory and auditory-visual intelligibility of speech in fluctuating maskers for normal-hearing and hearing-impaired listeners
    Joshua G W Bernstein
    Army Audiology and Speech Center, Walter Reed Army Medical Center, Washington, DC 20307, USA
    J Acoust Soc Am 125:3358-72. 2009
    b>Speech intelligibility for audio-alone and audiovisual (AV) sentences was estimated as a function of signal-to-noise ratio (SNR) for a female target talker presented in a stationary noise, an interfering male talker, or a speech-modulated ..
  49. pmc Connected speech production in three variants of primary progressive aphasia
    Stephen M Wilson
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143, USA
    Brain 133:2069-88. 2010
    Primary progressive aphasia is a clinical syndrome defined by progressive deficits isolated to speech and/or language, and can be classified into non-fluent, semantic and logopenic variants based on motor speech, linguistic and cognitive ..
  50. pmc Subjective loudness and reality of auditory verbal hallucinations and activation of the inner speech processing network
    Ans Vercammen
    Department of Neuroscience, University Medical Center Groningen, Groningen, The Netherlands
    Schizophr Bull 37:1009-16. 2011
    ..verbal hallucinations (AVH) suggests that a failure to adequately monitor the production of one's own inner speech leads to verbal thought being misidentified as an alien voice...
  51. ncbi Reaction time analysis of two types of motor preparation for speech articulation: action as a sequence of chunks
    Stuart T Klapp
    Department of Psychology, California State University, Hayward, CA 94542, USA
    J Mot Behav 35:135-50. 2003
    Reaction time (RT) prior to speech articulation increased as a function of response complexity. The RT findings formed 2 patterns, each of which was a different Response Complexity x Paradigm (choice RT vs. simple RT) interaction...
  52. ncbi Seeing and hearing speech excites the motor system involved in speech production
    K E Watkins
    Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Neuropsychologia 41:989-94. 2003
    ..We examined the possibility that perception of speech, both auditory and visual, would also result in changes in the excitability of the motor system underlying speech ..
  53. doi The contribution of the inferior parietal cortex to spoken language production
    Fatemeh Geranmayeh
    Division of Experimental Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
    Brain Lang 121:47-57. 2012
    ..MRI study investigated the involvement of the left inferior parietal cortex (IPC) in spoken language production (Speech)...
  54. doi Music training for the development of speech segmentation
    Clement Francois
    Institut de Neurosciences des Systèmes, INSERM and Aix Marseille University, Marseille, France
    Cereb Cortex 23:2038-43. 2013
    ..electrophysiological measures and a test-training-retest procedure to examine the influence of music training on speech segmentation in 8-year-old children...
  55. pmc Functional activation in the cerebellum during working memory and simple speech tasks
    Corrine Durisko
    Learning Research and Development Center, University of Pittsburgh, 3939 O Hara Street, Pittsburgh, PA 15260, USA
    Cortex 46:896-906. 2010
    ..because it relies more heavily on articulatory rehearsal, and our comparison tasks included both overt and covert speech tasks. Our results provide some support for the Desmond et al. (1997) model...
  56. ncbi Shared and distinct neural correlates of singing and speaking
    Elif Ozdemir
    Music and Neuroimaging Laboratory, Beth Israel Deaconess Medical Center Harvard Medical School, 330 Brookline Ave, Palmer 127, Boston, MA 02215, USA
    Neuroimage 33:628-35. 2006
    ....
  57. ncbi The influence of ambient speech on adult speech productions through unintentional imitation
    Véronique Delvaux
    Fonds National de la Recherche Scientifique, Bruxelles, Belgique
    Phonetica 64:145-73. 2007
    This paper deals with the influence of ambient speech on individual speech productions...
  58. doi Speech and gesture in spatial language and cognition among the Yucatec Mayas
    Olivier Le Guen
    Max Planck Institute, Language and Cognition Group, Nijmegen, and CIESAS, Lingüística antropológica, Mexico DF
    Cogn Sci 35:905-38. 2011
    In previous analyses of the influence of language on cognition, speech has been the main channel examined...
  59. pmc From phonemes to articulatory codes: an fMRI study of the role of Broca's area in speech production
    Marina Papoutsi
    Institute for Adaptive and Neural Computation, University of Edinburgh, UK
    Cereb Cortex 19:2156-65. 2009
    ..We further discuss our findings with respect to the mechanisms of phonetic encoding and provide evidence in support of a functional segregation of the posterior part of Broca's area, the pars opercularis...
  60. pmc Vocalization-induced enhancement of the auditory cortex responsiveness during voice F0 feedback perturbation
    Roozbeh Behroozmand
    Speech Physiology Laboratory, Department of Communication Science and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208, USA
    Clin Neurophysiol 120:1303-12. 2009
    ....
  61. pmc Single-trial speech suppression of auditory cortex activity in humans
    Adeen Flinker
    Helen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, California 94720, USA
    J Neurosci 30:16643-50. 2010
    The human auditory cortex is engaged in monitoring the speech of interlocutors as well as self-generated speech...
  62. ncbi Tuned to the signal: the privileged status of speech for young infants
    Athena Vouloumanos
    Department of Psychology, University of British Columbia, Canada
    Dev Sci 7:270-6. 2004
    Do young infants treat speech as a special signal, compared with structurally similar non-speech sounds? We presented 2- to 7-month-old infants with nonsense speech sounds and complex non-speech analogues...
  63. ncbi Fine-tuning of auditory cortex during speech production
    Theda H Heinks-Maldonado
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Psychophysiology 42:180-90. 2005
    ..The specificity of the auditory cortical suppression to self-produced speech, a prediction derived from the posited operation of a precise forward model system, has not been established...
  64. pmc The contribution of the parietal lobes to speaking and writing
    Sonia L E Brownsett
    Division of Neuroscience and Mental Health and Medical Research Council Clinical Sciences Centre, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Cereb Cortex 20:517-23. 2010
    ..In contrast, action-related parietal activity during speech production was confined to primary somatosensory cortex...
  65. pmc Case report: Retracing atypical development: a preserved speech variant of Rett syndrome
    Peter B Marschik
    Institute of Physiology Developmental Physiology and Developmental Neurology, Center for Physiological Medicine, Medical University of Graz, Harrachgasse 21 5, Graz 8010, Austria
    J Autism Dev Disord 39:958-61. 2009
    The subject of the present study is the development of a girl with the preserved speech variant of Rett disorder. Our data are based on detailed retrospective and prospective video analyses...
  66. pmc Neural systems for speech and song in autism
    Grace Lai
    Department of Neuroscience, Columbia University Medical Centre, New York, NY 10032, USA
    Brain 135:961-75. 2012
    ..associated with these functions typically overlap, enabling investigation of neural organization supporting speech and song in autism...
  67. doi Tracking lexical access in speech production: electrophysiological correlates of word frequency and cognate effects
    Kristof Strijkers
    Universitat de Barcelona, Department of Psicologia Basica, GRNC, 08035 Barcelona, Cataluña, Spain
    Cereb Cortex 20:912-28. 2010
    The present study establishes an electrophysiological index of lexical access in speech production by exploring the locus of the frequency and cognate effects during overt naming...
  68. pmc Identifying cortical lateralization of speech processing in infants using near-infrared spectroscopy
    Heather Bortfeld
    Department of Psychology, Texas A and M University, College Station, Texas 77843, USA
    Dev Neuropsychol 34:52-65. 2009
    We investigate the utility of near-infrared spectroscopy (NIRS) as an alternative technique for studying infant speech processing...
  69. ncbi The effect of unilateral electrostimulation of the subthalamic nucleus on respiratory/phonatory subsystems of speech production in Parkinson's disease--a preliminary report
    Emily Wang
    Department of Communication Disorders and Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Clin Linguist Phon 17:283-9. 2003
    ..study investigating the effect of unilateral electrostimulation of the subthalamic nucleus (STN) on different speech subsystems in people with Parkinson's disease (PD)...
  70. ncbi Birdsong and human speech: common themes and mechanisms
    A J Doupe
    Department of Psychiatry, University of California at San Francisco 94143, USA
    Annu Rev Neurosci 22:567-631. 1999
    Human speech and birdsong have numerous parallels...
  71. ncbi Auditory-motor interaction revealed by fMRI: speech, music, and working memory in area Spt
    Gregory Hickok
    University of California, Irvine, CA 92697, USA
    J Cogn Neurosci 15:673-82. 2003
    The concept of auditory-motor interaction pervades speech science research, yet the cortical systems supporting this interface have not been elucidated...
  72. doi The motor somatotopy of speech perception
    Alessandro D'Ausilio
    DSBTA, Section of Human Physiology, University of Ferrara, Ferrara 44100, Italy
    Curr Biol 19:381-5. 2009
    Listening to speech recruits a network of fronto-temporo-parietal cortical areas. Classical models consider anterior (motor) sites to be involved in speech production whereas posterior sites are considered to be involved in comprehension...
  73. ncbi Voice-selective areas in human auditory cortex
    P Belin
    Neuropsychology Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Quebec, Canada
    Nature 403:309-12. 2000
    ..These regions showed greater neuronal activity when subjects listened passively to vocal sounds, whether speech or non-speech, than to non-vocal environmental sounds...
  74. ncbi An fMRI investigation of syllable sequence production
    Jason W Bohland
    Department of Cognitive and Neural Systems, Boston University, 677 Beacon Street, Boston, MA 02215, USA
    Neuroimage 32:821-41. 2006
    Fluent speech comprises sequences that are composed from a finite alphabet of learned words, syllables, and phonemes...
  75. pmc Functional subdivisions in the left angular gyrus where the semantic system meets and diverges from the default network
    Mohamed L Seghier
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 30:16809-17. 2010
    ..fMRI) data during fixation and eight goal directed tasks that involved semantic matching, perceptual matching or speech production in response to familiar or unfamiliar stimuli presented in either verbal (letters) or nonverbal (..
  76. pmc Giving speech a hand: gesture modulates activity in auditory cortex during speech perception
    Amy L Hubbard
    Ahmanson Lovelace Brain Mapping Center, University of California, Los Angeles, California 90095 7085, USA
    Hum Brain Mapp 30:1028-37. 2009
    Viewing hand gestures during face-to-face communication affects speech perception and comprehension...
  77. pmc Speech target modulates speaking induced suppression in auditory cortex
    Maria I Ventura
    Department of Otolaryngology, University of California, San Francisco, San Francisco, CA, USA
    BMC Neurosci 10:58. 2009
    ..have demonstrated speaking-induced suppression (SIS) in the auditory cortex during vocalization tasks wherein the M100 response to a subject's own speaking is reduced compared to the response when they hear playback of their speech.
  78. ncbi Exposure to asynchronous audiovisual speech extends the temporal window for audiovisual integration
    Jordi Navarra
    Grup de Recerca Neurociencia Cognitiva, Parc Cientific de Barcelona, Spain
    Brain Res Cogn Brain Res 25:499-507. 2005
    We examined whether monitoring asynchronous audiovisual speech induces a general temporal recalibration of auditory and visual sensory processing...
  79. ncbi Endogenous cortical rhythms determine cerebral specialization for speech perception and production
    Anne Lise Giraud
    INSERM, U742, Paris, F 75005, France
    Neuron 56:1127-34. 2007
    Across multiple timescales, acoustic regularities of speech match rhythmic properties of both the auditory and motor systems...
  80. ncbi Modulation of the auditory cortex during speech: an MEG study
    John F Houde
    Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
    J Cogn Neurosci 14:1125-38. 2002
    Several behavioral and brain imaging studies have demonstrated a significant interaction between speech perception and speech production...
  81. pmc The natural statistics of audiovisual speech
    Chandramouli Chandrasekaran
    Neuroscience Institute, Princeton University, Princeton, New Jersey, USA
    PLoS Comput Biol 5:e1000436. 2009
    ..class of multisensory signals for which a quantitative input space characterization is unavailable is human speech. We do not understand what signals our brain has to actively piece together from an audiovisual speech stream to ..
  82. pmc Temporal context in speech processing and attentional stream selection: a behavioral and neural perspective
    Elana M Zion Golumbic
    Department of Psychiatry, Columbia University Medical Center, 710 W 168th St, New York, NY 10032, USA
    Brain Lang 122:151-61. 2012
    The human capacity for processing speech is remarkable, especially given that information in speech unfolds over multiple time scales concurrently...
  83. pmc The modulation transfer function for speech intelligibility
    TAFFETA M ELLIOTT
    Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, United States of America
    PLoS Comput Biol 5:e1000302. 2009
    We systematically determined which spectrotemporal modulations in speech are necessary for comprehension by human listeners...
  84. pmc Spatiotemporal imaging of cortical activation during verb generation and picture naming
    Erik Edwards
    Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
    Neuroimage 50:291-301. 2010
    ..is seen at a larger timescale, showing distinct stages of perception, semantic association/selection, and speech production...
  85. pmc Hearing lips and seeing voices: how cortical areas supporting speech production mediate audiovisual speech perception
    Jeremy I Skipper
    Department of Neurology, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Cereb Cortex 17:2387-99. 2007
    Observing a speaker's mouth profoundly influences speech perception. For example, listeners perceive an "illusory" "ta" when the video of a face producing /ka/ is dubbed onto an audio /pa/...
  86. ncbi Do people use language production to make predictions during comprehension?
    Martin J Pickering
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Trends Cogn Sci 11:105-10. 2007
    ..This framework is in line with a general trend in cognitive science to incorporate action systems into perceptual systems and has broad implications for understanding the links between language production and comprehension...
  87. doi Physical and perceptual factors shape the neural mechanisms that integrate audiovisual signals in speech comprehension
    HweeLing Lee
    Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
    J Neurosci 31:11338-50. 2011
    ..input and top-down linguistic constraints in shaping the neural mechanisms specialized for integrating audiovisual speech signals are currently unknown...
  88. pmc The scalp-recorded brainstem response to speech: neural origins and plasticity
    Bharath Chandrasekaran
    Auditory Neuroscience Laboratory, Northwestern University, Evanston, IL 60208, USA
    Psychophysiology 47:236-46. 2010
    ..of the remarkable fidelity with which the human auditory brainstem represents key acoustic features of the speech signal...
  89. pmc Evo-devo, deep homology and FoxP2: implications for the evolution of speech and language
    Constance Scharff
    Department of Animal Behavior, Freie Universitat Berlin, Takustr 6, 14195 Berlin, Germany
    Philos Trans R Soc Lond B Biol Sci 366:2124-40. 2011
    ..Here, we apply this approach to the evolution of human language. Human speech is a form of auditory-guided, learned vocal motor behaviour that also evolved in certain species of birds, bats ..
  90. pmc Attentional gain control of ongoing cortical speech representations in a "cocktail party"
    Jess R Kerlin
    Center for Mind and Brain, University of California, Davis, California 95618, USA
    J Neurosci 30:620-8. 2010
    Normal listeners possess the remarkable perceptual ability to select a single speech stream among many competing talkers...
  91. ncbi An fMRI study of verbal self-monitoring: neural correlates of auditory verbal feedback
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Cereb Cortex 16:969-77. 2006
    The ability to recognize one's own inner speech is essential for a sense of self...
  92. pmc Perturbation of the left inferior frontal gyrus triggers adaptive plasticity in the right homologous area during speech production
    Gesa Hartwigsen
    Department of Neurology, Christian Albrechts University Kiel, 24105 Kiel, Germany
    Proc Natl Acad Sci U S A 110:16402-7. 2013
    ..the left anterior IFG (aIFG) or posterior IFG (pIFG) to test the anatomic specificity of the effects of cTBS on speech processing...
  93. doi Before speech: cerebral voice processing in infants
    Pascal Belin
    Department of Psychology and Centre for Cognitive Neuroimaging, University of Glasgow, Glasgow, Lanarkshire G12 8QQ, Scotland, UK
    Neuron 65:733-5. 2010
    ..We discuss the implications of these findings for our understanding of cerebral voice processing in the first months of life...
  94. ncbi The cortical organization of speech processing
    Gregory Hickok
    Department of Cognitive Sciences and The Center for Cognitive Neuroscience, University of California, Irvine, California 92697 5100, USA
    Nat Rev Neurosci 8:393-402. 2007
    Despite decades of research, the functional neuroanatomy of speech processing has been difficult to characterize...
  95. doi Enhanced perceptual processing of speech in autism
    Anna Järvinen-Pasley
    Goldsmiths College, University of London, UK
    Dev Sci 11:109-21. 2008
    ..Whereas children with autism exhibited superior perceptual processing of speech relative to controls, and showed no evidence of either a perceptual or semantic processing bias, controls showed a ..
  96. pmc Speech rhythms and multiplexed oscillatory sensory coding in the human brain
    Joachim Gross
    Institute for Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom
    PLoS Biol 11:e1001752. 2013
    Cortical oscillations are likely candidates for segmentation and coding of continuous speech. Here, we monitored continuous speech processing with magnetoencephalography (MEG) to unravel the principles of speech segmentation and coding...
  97. doi Neural coding of formant-exaggerated speech in the infant brain
    Yang Zhang
    Department of Speech Language Hearing Sciences, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Sci 14:566-81. 2011
    b>Speech scientists have long proposed that formant exaggeration in infant-directed speech plays an important role in language acquisition...
  98. doi Relations between frequency selectivity, temporal fine-structure processing, and speech reception in impaired hearing
    Olaf Strelcyk
    Centre for Applied Hearing Research, Department of Electrical Engineering, Technical University of Denmark, Building 352, Orsteds Plads, 2800 Kgs Lyngby, Denmark
    J Acoust Soc Am 125:3328-45. 2009
    Frequency selectivity, temporal fine-structure (TFS) processing, and speech reception were assessed for six normal-hearing (NH) listeners, ten sensorineurally hearing-impaired (HI) listeners with similar high-frequency losses, and two ..
  99. pmc Towards a new neurobiology of language
    David Poeppel
    Department of Psychology and Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 32:14125-31. 2012
    ..in the cognitive neurosciences are profoundly changing how we investigate and conceive of the neural basis of speech and language processing...
  100. doi Cerebral hemodynamics in newborn infants exposed to speech sounds: a whole-head optical topography study
    Hiroki Sato
    Hitachi, Ltd, Advanced Research Laboratory, Saitama, Japan JST Japan Science and Technology Agency CREST Core Research for Evolutional Science and Technology, Saitama, Japan
    Hum Brain Mapp 33:2092-103. 2012
    Considerable knowledge on neural development related to speech perception has been obtained by functional imaging studies using near-infrared spectroscopy (optical topography)...
  101. ncbi The Speech, Spatial and Qualities of Hearing Scale (SSQ)
    Stuart Gatehouse
    MRC Institute of Hearing Research, Glasgow, UK
    Int J Audiol 43:85-99. 2004
    The Speech, Spatial and Qualities of Hearing Scale (SSQ) is designed to measure a range of hearing disabilities across several domains...

Research Grants83

  1. HEART RATE ACTIVITY AND INFANT SPEECH PERCEPTION
    ROBIN PANNETON; Fiscal Year: 2002
    ..Description) Across the world, adults exaggerate many of the prosodic and linguistic attributes of their speech when talking to infants...
  2. NEUROMOTOR BASIS OF STUTTERING
    MICHAEL MCCLEAN; Fiscal Year: 2003
    ..are an enhanced understanding of the neuromotor basis of stuttering and the development of improved forms of speech therapy for persons who stutter. The problem of stuttering can reasonably be viewed as a motor disorder...
  3. Linguapalatal Contact Pressures During Speech
    JEFFREY SEARL; Fiscal Year: 2003
    Abnormalities in tongue strength, range of motion, and coordination are primary contributors to speech deficits resulting from stroke, head injury, neuromuscular disease, oral cancer, and developmental delays...
  4. Effects of sensorineural loss on robust speech coding
    Michael Heinz; Fiscal Year: 2007
    b>Speech perception by listeners with normal hearing is robust across a wide variety of conditions, whereas people with sensorineural hearing loss (SNHL) typically show much less robust speech perception...
  5. User Adaptation of AAC Device Voices
    JAN VAN SANTEN; Fiscal Year: 2007
    ..many voice enabled AAC devices are currently available, they lack the important ability to generate customized speech that mimics aspects of the user's past or intermittently available speech...
  6. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech.
  7. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    ..than normal incidence of impaired cardiac function, autonomic nervous system disorders, sleep disorders, delayed speech and central and obstructive apneas...
  8. Human middle-ear imaging, physiology, and biomechanics
    CHARLES RICHARD STEELE; Fiscal Year: 2013
    ..Specific Aim #3: Ear surgeons target restoration of hearing in the speech frequency range, and not in the higher frequencies where important sound localization cues are known to reside...
  9. Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity
    Vickram Ramkumar; Fiscal Year: 2013
    ..Loss of hearing at this developmental stage hampers speech, cognition and social development...
  10. Anti-Bacterial Innate Responses Enhance Paramyxovirus Replication
    Griffith D Parks; Fiscal Year: 2010
    ..Sequelae of recurrent otitis media include hearing and speech impairment that significantly impact the quality of life of both children and their parents/caregivers...
  11. WIDEBAND CLINICAL DIAGNOSIS AND MONITORING OF MIDDLE-EAR AND COCHLEAR FUNCTION
    Douglas H Keefe; Fiscal Year: 2013
    ..The ATF test provides admittance, absorbance and reflectance responses over frequencies important for speech perception (0.2-8 kHz), and is performed either at ambient pressure or as a WB tympanogram...
  12. Human in Mouse Modeling of HNSCC to Predict Resonse to Therapy
    Wendell G Yarbrough; Fiscal Year: 2010
    ..Due to the critical role of structures of the upper aerodigestive tract in speech and swallowing and due to the concentration of cranial nerves and major blood vessels in the neck, standard ..
  13. Basic and Clinical Studies of Noise-Induced and Age-Related Hearing Loss
    Sharon G Kujawa; Fiscal Year: 2012
    ..e. problems understanding speech in a noisy environment...
  14. Development of a Porcine Model of Ataxia-Telangiectasia
    Christopher Rogers; Fiscal Year: 2011
    ..Current treatments for A-T are directed primarily toward the management of symptoms. Physical and speech therapy may improve the daily lives of patients, and 3-globulin injections can be given to support the immune ..
  15. Air Toxics, Neighborhood Environment and Risk of Oral Clefts
    Philip J Lupo; Fiscal Year: 2013
    ..Children with CL[unreadable]P suffer deficits in speech, hearing and cognition and have higher morbidity and mortality throughout life compared to their unaffected ..
  16. Core Center for BioBehavioral Sciences of Communication Disorders
    Mabel L Rice; Fiscal Year: 2013
    ..The topics focus on speech and language impairments, with a new investigator of hearing/balance impairments...
  17. Development of a Porcine Model of Ataxia-Telangiectasia
    Christopher Rogers; Fiscal Year: 2013
    ..Current treatments for A-T are directed toward the management of symptoms. Physical and speech therapy can improve the lives of patients, and [unreadable]-globulin injections can be given to support the immune ..
  18. CODING IN AUDITORY NEURONS: EFFECTS OF AMINO ACIDS
    Donald M Caspary; Fiscal Year: 2013
    ..in young and elderly subjects with similar thresholds show age-related decrements in temporal processing and speech understanding in noise...
  19. Feasibility and Preliminary Efficacy of Yoga in Head and Neck Cancer Survivors
    Sheila H Ridner; Fiscal Year: 2013
    ..This improvement is associated with late toxicities including functional deficits such as: 1) impaired speech and swallowing, 2) general functional impairment (e.g...
  20. Biology of the HMW1 and HMW2 Adhesins of H. Influenzae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    ..months and is associated with significant hearing deficit, a sequela that in turn can impair language acquisition, speech development, and school performance. The initial step in the pathogenesis of disease due to nontypable H...
  21. A Phase II Trial of Levodopa in Angelman Syndrome
    Wen Hann Tan; Fiscal Year: 2013
    ..AS is characterized by mental retardation, limited speech, seizures, abnormal movements such as tremors, and ataxic gait...
  22. Control of Breathing and Pompe Disease
    David D Fuller; Fiscal Year: 2013
    ..The hypoglossal motor system is being emphasized since it is impaired in Pompe disease with consequences to speech, swallow and breathing and does not respond to intravenous ERT...
  23. Oral Immunobiology of MCMV-infected Mouse Salivary Glands
    Steven D London; Fiscal Year: 2010
    ..Saliva functions to moisten the oral tissues as an aid for speech, as a solvent important for taste, and as a masticatory wetting agent/lubricant important in swallowing food...
  24. Translational refinement of adaptive communication system for locked-in patients
    Melanie Fried-Oken; Fiscal Year: 2013
    ..Individuals with severe speech and physical impairments (SSPI) resulting from acquired neurological disorders (amyotrophic lateral sclerosis, ..
  25. Bilateral cochlear implants: Physiology and psychophysics
    Bertrand Delgutte; Fiscal Year: 2012
    ..While wearers of bilateral implants show improved sound localization and speech reception in noise, their ability to process interaural time differences (ITD) is still far from normal, resulting ..
  26. GENETIC ORGANIZATION OF RESPIRATORY CIRCUITS IN MOUSE BRAINSTEM
    Paul Gray; Fiscal Year: 2013
    ..on a breath by breath basis, to meet changing respiratory and behavioral demands such as arise from exercise, or speech. A number of disorders of human health are directly related to the brainstem networks underlying breathing such as ..
  27. Proteomic Approach for Early Detection of Head and Neck Cancer
    Ho Sheng Lin; Fiscal Year: 2012
    ..enduring radical treatments which often result in significant physical disfigurement as well as dysfunction of speech, breathing, and swallowing, these patients'prognosis remains dismal with 5-year survival of less than 40%...
  28. South Carolina Study for Adolescents and Young Adults with Rare Conditions
    SUZANNE W MCDERMOTT; Fiscal Year: 2013
    ..services (including type and specialty of health care provider by specialty, physical and occupational therapy, speech/language therapy, counseling and other services)...
  29. Coordination of orofacial and respiratory movements
    Detlef H Heck; Fiscal Year: 2012
    ..in human health conditions such as sudden infant death syndrome (SIDS), swallowing dysfunction (dysphagia) and speech disorders (dysarthria). The cerebellum has long been implicated in the coordination of body movements and posture...
  30. Genone-wide Discovery of Molecular Alterations in Head and Neck Cancer
    Victor E Velculescu; Fiscal Year: 2010
    ..Oral cancer affects physical appearance and vital functions, including taste, swallowing, and speech/phonation...
  31. PASSY-MUIR SWALLOWING SELF TRAINING DEVICE TO ENCHANCE RECOVERY POST STROKE
    CHRISTY LESLIE LUDLOW; Fiscal Year: 2012
    ..b>Speech pathologists will train patients and their caregivers to use the Passy Muir Swallowing Self Trainer before ..
  32. Sensorimotor Control of the Human Orofacial System
    Steven M Barlow; Fiscal Year: 2012
    ..The Bayley III Developmental Scales and a battery of standardized articulation, vocabulary, grammar, and speech-language probes will provide vital information on production and reception...
  33. Quality of Life in Children with Cleft
    Hillary L Broder; Fiscal Year: 2013
    Individuals with clefts have a myriad of special needs including speech and language problems, facial differences, atypical dental development, malocclusion, learning disabilities, chronic ear infections as well as associated ..
  34. Insm1 in Development of Spiral and Vestibular Ganglia
    Sarah M Lorenzen; Fiscal Year: 2013
    ..implants, which depend on the spiral ganglion neurons (SGNs) for conducting auditory information including human speech. However, the SGNs can be damaged or degenerate in the absence of stimulation from the hair cells, rendering ..
  35. Advanced technology for neural interfaces based on microstimulation
    DOUGLAS BUCHANAN MCCREERY; Fiscal Year: 2013
    ..and basic neuroscience, and to advance the development of cochlear nucleus auditory prostheses towards providing speech recognition that is at least equivalent to that of users of cochlear implants...
  36. Aging Auditory System: Presbycusis and Its Neural Bases
    Robert D Frisina; Fiscal Year: 2013
    ..two main perceptual problems;loss in sensitivity biased toward the higher frequencies critical for understanding speech, and a serious reduction in sound processing capacity essential for understanding speech in background noise...
  37. Immune Responses in Otitis Prone Children
    Michael E Pichichero; Fiscal Year: 2013
    ..During AOM, children typically have diminished hearing and this can lead to temporary delayed speech and language development and possibly permanent hearing loss...
  38. Furlow Palatoplasty with Tensor Tenopexy for Otitis Media
    Joseph E Losee; Fiscal Year: 2013
    ..e. velopharyngeal competence, speech development and the need for revision palatoplasty...
  39. Integrative Neural Systems Underlying Vital Aerodigestive Tract Functions
    Joanne Robbins; Fiscal Year: 2010
    ..for the first interaction among several clinical investigators and basic scientists including but not limited to: speech language pathologists, otolaryngologists, neurologists, physiologists, sleep medicine specialists, biomedical ..
  40. The Charge Study: Childhood Autism Risks from Genetics and the Environment
    Irva Hertz-Picciotto; Fiscal Year: 2013
    ..associations not only with development of ASD and intellectual impairment in the children, but also with specific speech and language delays, behavioral phenotypes such as attention deficits or hyperactivity, and gene expression...
  41. Gene-Expression Patterns During Hair-Cell Regeneration
    ALBERT JAMES HUDSPETH; Fiscal Year: 2010
    ..to its annual cost in the United States of more than $80 billion, hearing disease delays the acquisition of speech in infants, isolates the elderly, and depresses affected individuals of all ages...
  42. Neural substrates for matching hearing to utterance
    Darcy B Kelley; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE Several human speech disorders are attributable to impaired function of auditory/vocal linkages...
  43. Effectiveness of Therapy via Telemedicine following Cochlear Implants
    Anu Sharma; Fiscal Year: 2013
    ..These children have varying degrees of deafness, and are likely to have impaired speech and language...
  44. CYTOKINE INFLAMMATORY MEDIATORS AND MUCIN REGULATION IN MIDDLE EAR EPITHELIUM
    Joseph E Kerschner; Fiscal Year: 2013
    ..antimicrobial therapy in children [5], is the most common cause of hearing loss in young children and can lead to speech, language, educational and other developmental delays [6]...
  45. Sound Source Segregation
    Mark A Bee; Fiscal Year: 2013
    ..Similarly, computer algorithms for automated speech recognition (ASR) also have persistent difficulty segregating multiple sources...
  46. Neural Substrates of Oral Motor Dysfunction in Parkinson's Disease
    EMILY KATE PRINE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Speech and swallowing impairments occur in 90% of Parkinson's Disease (PD) patients and aspiration pneumonia is the leading cause of death...
  47. Brain Activation in Humans
    Andrew J Butler; Fiscal Year: 2012
    ..These studies used task or stimulus-based paradigms such as hand movements, speech production or passive observation of visual stimulus...
  48. Synaptic basis of perceptual learning in primary auditory cortex
    ROBERT CROOKS FROEMKE; Fiscal Year: 2013
    ..an important feature of the auditory cortex, especially for learning the significance of sensory signals such as speech, for the use of devices such as cochlear implants, and for recovery after short-term deafness...
  49. Cocktail Party Problem: Perspective on Neurobiology of Auditory Scene Analysis
    Mounya Elhilali; Fiscal Year: 2013
    ..military and robotics domains;as well as improving communication aids (hearing aids, cochlear implants, speech-based human-computer interfaces) for the sensory-impaired and aging brains...
  50. The effect of a protein-lipid complex from human milk against pneumococcal otitis
    Emily Clementi; Fiscal Year: 2013
    ..If left untreated, a prolonged infection can lead to serious complications, including delays in speech and language development and even permanent hearing impairment...
  51. 8th Annual Conference on Head and Neck Cancer
    Eben L Rosenthal; Fiscal Year: 2012
    ..those areas within and between the multiple disciplines represented;ii) to recognize the important role of nurses, speech pathologists, audiologists, nutritionists, social workers, pain specialists, mental health practitioners, physical ..
  52. Effects of Sensorineural Hearing Loss on Robust Speech Coding
    Michael G Heinz; Fiscal Year: 2013
    ..hearing impairment comes from the fact that people with similar degrees of hearing loss may have different speech recognition abilities...
  53. Characterization of cranial dermal bone-specific miRNAs
    ARKHAT ABZHANOV; Fiscal Year: 2012
    ..are often associated with severe disabilities, cancers, hearing loss, problems related to breathing, eating, and speech. We aim to understand mechanisms of the cranial bone development and morphogenesis in normal and abnormal ..
  54. Cross-modal re-organization in children with cochlear implants
    Julia Dee Campbell; Fiscal Year: 2013
    ..been shown to be critical for appropriate stimulation of central auditory pathways and subsequent development of speech and language skills...
  55. Stress and Drug Use Vulnerability in Rural African Americans
    Ezemenari M Obasi; Fiscal Year: 2010
    ..Subjects (N = 100) will be randomly assigned into one of two speech tasks: (a) shoplifting or (b) experience of discrimination...
  56. The North Carolina Cleft Outcomes Study
    Ronald P Strauss; Fiscal Year: 2013
    ..A secondary objective is to assess timeliness of services, including speech and language and genetic services, surgical outcomes, use and costs of team care, out of pocket expenses, and ..
  57. Cholinergic inputs to excitatory and inhibitory midbrain auditory circuits
    JEFFREY GARRETT MELLOTT; Fiscal Year: 2013
    ..in a wide range of auditory functions, including selective attention, plasticity and learning, and understanding speech in noisy environments...
  58. Effects of octanoic acid for treatment of essential voice tremor
    SOREN YVETTE LOWELL; Fiscal Year: 2013
    ..In essential voice tremor (EVT), repetitive movements of voice-related structures produce modulations of the speech signal...
  59. Neural Coding and Perception of Learned Vocalizations
    SARAH M WOOLLEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vocal communication is important for human learning and social interaction. Speech perception impairments are features of neurological disorders such as auditory processing disorder (APD) and autism...
  60. Planning Grant for Genome-Wide Association Study of Craniofacial Microsomia
    JACQUELINE R contact STARR; Fiscal Year: 2010
    ..Typically affecting the jaw and ear, CFM impairs basic functions such as hearing, speech, respiration, and chewing, in addition to its aesthetic effects...
  61. 2013 International Meeting on the Molecular Biology of Hepatitis B Viruses
    Shuping Tong; Fiscal Year: 2013
    ..The keynote speech by William Mason, a respected leader in the HBV field, will summarize major accomplishments of the field and point ..
  62. Physical, Cognitive and Mental Health in Social Context
    Michael Marsiske; Fiscal Year: 2013
    ..linguistics, neurology, neuropsychology, neuroscience, nursing, occupational therapy, psychology, sociology, and speech pathology...
  63. Auditory Processing of Stochastic FM in Relationship to Speech Perception
    STANLEY E SHEFT; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The most common complaint associated with hearing loss is understanding speech, especially in adverse listening situations...
  64. Multiple roles of inhibition in temporal coding of sensory information
    Ariel Lyons-Warren; Fiscal Year: 2012
    ..Temporal coding is also important for recognizing features of human speech such as vowel sound duration, phoneme discrimination, and pause length;all of which involve very precise, small ..
  65. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Christian Brown; Fiscal Year: 2013
    ..Interruption of these systems would severely damage important processes like speech discrimination and render the inner ear more vulnerable to damage...
  66. Optogenetic inhibition of motor neuron and muscle activity in vivo
    Scott L Delp; Fiscal Year: 2013
    ..disorders and injuries frequently result in spasticity and involuntary muscle contractions that interfere with speech, movement and activities of daily living...
  67. Integrated EEG/NIR Sensor System for Infants
    Catherine Poulsen; Fiscal Year: 2013
    ..The functional data task wil present simple speech and matched non-speech sounds that have previously resulted in individual differences in brain electrical patterns ..
  68. Pre-clinical Models of Odontic Analogs by Endogenous Stem Cells
    Jeremy J Mao; Fiscal Year: 2013
    ..one's self-esteem and impairs multiple physiological functions including mastication, digestion and/or speech. In this application that is specifically designed in response to PA-10-009, Bioengineering Research Grants (BRG), ..
  69. Evaluation of Approaches to Auditory Rehabilitation for Mild TBI
    Gabrielle Saunders; Fiscal Year: 2009
    ..FM systems substantially improve the signal-to-noise ratio of speech in noisy and reverberant environments, theoretically making more resources available for higher level processing...
  70. Speech Therapy Robot (STR) to assist in the administration of evidence based spee
    Garima Srivastava; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): This SBIR phase I project will develop a Speech Therapy Robot (STR) to assist in the administration of evidence-based speech and language therapy to provide individualized monitoring of multiple ..
  71. Determinants of Word Recognition Speed in Older Listeners
    Frederick J Gallun; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Project Summary/Abstract A hallmark of aging is difficulty understanding speech spoken rapidly or in noisy or reverberant conditions...
  72. NEURAL NETWORK MODELING OF SPEECH PRODUCTION
    Frank Guenther; Fiscal Year: 2000
    ..research are to elucidate the stages of speaking skill development in infants and the motor control mechanisms for speech production in adults...
  73. Acoustic and Respiratory System Correlates of Pausing
    Janet Slifka; Fiscal Year: 2009
    DESCRIPTION: The insertion of pauses in the speech stream contributes to the effectiveness and naturalness of speech. Pauses provide structure to the speech stream (boundaries), signal discourse control (e.g...
  74. Speech Perception Assessment and Training System for Aphasia Rehabilitation
    James D Miller; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This project will test the feasibility of a computerized speech perception assessment and training system (SPATS-AR) as a novel aphasia rehabilitation option...
  75. Multi-site study of speech perception training for hearing-aid users
    Charles S Watson; Fiscal Year: 2010
    ..Many of those who try to use hearing aids decide that they are not able to understand speech well enough with them to justify their cost...
  76. Auditory enhancement in female speech
    Andrew Lotto; Fiscal Year: 2001
    DESCRIPTION: Females produce speech with a higher fundamental frequency (f0, voice pitch) as compared to male-produced speech...
  77. Virtual Therapist Speech Treatment for Parkinson Disease
    RONALD COLE; Fiscal Year: 2005
    Our previous studies have generated the first short- and long-term experimental efficacy data for speech treatment for individuals with Idiopathic Parkinson disease (IPD), documenting acoustic, aerodynamic and physiologic changes ..
  78. SPEECH PROCESSORS FOR AUDITORY PROSTHESES
    BLAKE WILSON; Fiscal Year: 2000
    The objective of this contract is to design, develop and evaluate both laboratory based and wearable speech processors for use in auditory prostheses...
  79. AUDITORY TRAINING FOR PERSONS WITH DIFFICULTY UNDERSTANDING SPEECH IN NOISE
    Kanae Nishi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Speech perception in adverse listening environments (e.g., noise) is more difficult than in quiet even for individuals with normal hearing...
  80. Advanced Technology and Tools for DBS Programming for Speech Functionality
    Craig van Horne; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Speech is a complex motor behavior often disrupted by neurological dysfunction. Parkinson's disease (PD) is one of the main disorders disrupting speech...
  81. Sensitivity to spectral cues in infant speech perception
    CHRISTIAN EDMUND STILP; Fiscal Year: 2010
    ..provided by applicant): The proposed research will examine infants'sensitivity to multiple spectral cues in speech perception. Speech is a complex signal, with numerous acoustic cues for every consonant and vowel...
  82. Children's Perception of Foreign-Accented Speech
    Tessa Bent; Fiscal Year: 2010
    ..program is to increase our understanding of how listeners develop the skills to compensate for variability in the speech signal and how hearing loss influences the development of these skills...
  83. Optimized Conditioned Processing for Cochlear Implants
    Jay T Rubinstein; Fiscal Year: 2010
    High levels of speech perception in quiet are currently available to a significant percentage of modern cdchlear implant recipients...