logic

Summary

Summary: The science that investigates the principles governing correct or reliable inference and deals with the canons and criteria of validity in thought and demonstration. This system of reasoning is applicable to any branch of knowledge or study. (Random House Unabridged Dictionary, 2d ed & Sippl, Computer Dictionary, 4th ed)

Top Publications

  1. ncbi Amplifying genetic logic gates
    Jérôme Bonnet
    Department of Bioengineering, Y2E2 269B, 473 Via Ortega, Stanford, CA 94305 4201, USA
    Science 340:599-603. 2013
  2. pmc Genetic programs constructed from layered logic gates in single cells
    Tae Seok Moon
    Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 491:249-53. 2012
  3. ncbi Enzyme-free nucleic acid logic circuits
    Georg Seelig
    Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Science 314:1585-8. 2006
  4. ncbi Signal propagation and logic gating in networks of integrate-and-fire neurons
    Tim P Vogels
    Volen Center for Complex Systems and Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 25:10786-95. 2005
  5. pmc Mechanistic logic underlying the axonal transport of cytosolic proteins
    David A Scott
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 70:441-54. 2011
  6. pmc Logic-based models for the analysis of cell signaling networks
    Melody K Morris
    Center for Cell Decision Process and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biochemistry 49:3216-24. 2010
  7. pmc CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms
    Camille Terfve
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
    BMC Syst Biol 6:133. 2012
  8. ncbi Customizing cell signaling using engineered genetic logic circuits
    Baojun Wang
    Department of Mathematics, Imperial College London, London, UK
    Trends Microbiol 20:376-84. 2012
  9. pmc The logic of fashion cycles
    Alberto Acerbi
    Centre for the Study of Cultural Evolution, University of Stockholm, Stockholm, Sweden
    PLoS ONE 7:e32541. 2012
  10. ncbi The molecular logic for planarian regeneration along the anterior-posterior axis
    Yoshihiko Umesono
    RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Nature 500:73-6. 2013

Detail Information

Publications311 found, 100 shown here

  1. ncbi Amplifying genetic logic gates
    Jérôme Bonnet
    Department of Bioengineering, Y2E2 269B, 473 Via Ortega, Stanford, CA 94305 4201, USA
    Science 340:599-603. 2013
    ..Researchers have also engineered synthetic genetic logic to realize simpler, independent control of biological processes...
  2. pmc Genetic programs constructed from layered logic gates in single cells
    Tae Seok Moon
    Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 491:249-53. 2012
    ..These programs consist of integrated genetic circuits that individually implement operations ranging from digital logic to dynamic circuits, and they have been used in various cellular engineering applications, including the ..
  3. ncbi Enzyme-free nucleic acid logic circuits
    Georg Seelig
    Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA
    Science 314:1585-8. 2006
    ..To systematically create complex yet reliable circuits, electrical engineers use digital logic, wherein gates and subcircuits are composed modularly and signal restoration prevents signal degradation...
  4. ncbi Signal propagation and logic gating in networks of integrate-and-fire neurons
    Tim P Vogels
    Volen Center for Complex Systems and Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 25:10786-95. 2005
    ..Using this feature, we show how different types of logic gates can arise within the architecture of the random network through the strengthening of specific synapses.
  5. pmc Mechanistic logic underlying the axonal transport of cytosolic proteins
    David A Scott
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 70:441-54. 2011
    ..We propose a model where cytosolic proteins are transported by dynamically assembling into multiprotein complexes that are directly/indirectly conveyed by motors...
  6. pmc Logic-based models for the analysis of cell signaling networks
    Melody K Morris
    Center for Cell Decision Process and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biochemistry 49:3216-24. 2010
    ..Here we review recent advances in applying logic-based modeling to mammalian cell biology...
  7. pmc CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalisms
    Camille Terfve
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK
    BMC Syst Biol 6:133. 2012
    ..Context-specific medium/high throughput proteomic data measured upon perturbation is now relatively easy to obtain but formalisms that can take advantage of these features to build models of signaling are still comparatively scarce...
  8. ncbi Customizing cell signaling using engineered genetic logic circuits
    Baojun Wang
    Department of Mathematics, Imperial College London, London, UK
    Trends Microbiol 20:376-84. 2012
    ..Here, we summarize the current state-of-the-art of engineering synthetic genetic logic circuits to customize cellular signaling behaviors, and discuss their promising applications in biocomputing, ..
  9. pmc The logic of fashion cycles
    Alberto Acerbi
    Centre for the Study of Cultural Evolution, University of Stockholm, Stockholm, Sweden
    PLoS ONE 7:e32541. 2012
    ..We also establish that alternative theories, that fashions result from individuals signaling their social status, or from individuals randomly copying each other, do not satisfactorily reproduce these empirical observations...
  10. ncbi The molecular logic for planarian regeneration along the anterior-posterior axis
    Yoshihiko Umesono
    RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Nature 500:73-6. 2013
    ..Thus, we have confirmed the broad outline of Morgan's hypothesis, and refined it on the basis of our proposed default property of planarian stem cells. ..
  11. ncbi Molecular implementation of simple logic programs
    Tom Ran
    Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Nanotechnol 4:642-8. 2009
    ..Biomolecular implementations of finite automata and logic gates have already been developed...
  12. pmc Protein networks as logic functions in development and cancer
    Janusz Dutkowski
    Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS Comput Biol 7:e1002180. 2011
    ..For each case we apply a new method, called Network-Guided Forests, to identify predictive modules together with logic functions which tie the activity of each module to the activity of its component genes...
  13. ncbi Logic models of pathway biology
    Steven Watterson
    Division of Pathway Medicine, University of Edinburgh Medical School, 49 Little France Crescent, Edinburgh, Scotland, United Kingdom
    Drug Discov Today 13:447-56. 2008
    ..Such approaches, in particular logic methodologies, might also aid pathway selection and multiple target strategies during the drug discovery phase...
  14. pmc A reconfigurable NAND/NOR genetic logic gate
    Angel Goñi-Moreno
    School of Computing, Mathematics and Digital Technology, Manchester Metropolitan University, Manchester M1 5GD, United Kingdom
    BMC Syst Biol 6:126. 2012
    Engineering genetic Boolean logic circuits is a major research theme of synthetic biology...
  15. pmc The logic of inhibitory connectivity in the neocortex
    Elodie Fino
    HHMI, Department of Biological Sciences, Columbia University, New York, NY, USA
    Neuroscientist 19:228-37. 2013
    ..In a last section, the authors describe briefly the link between dense inhibitory networks and different interneuron functions described in the neocortex...
  16. ncbi Enzyme-based NAND and NOR logic gates with modular design
    Jian Zhou
    Department of Chemistry and Biomolecular Science, and NanoBio Laboratory NABLAB, Clarkson University, Potsdam New York 13699 5810, USA
    J Phys Chem B 113:16065-70. 2009
    The logic gates NAND/NOR were mimicked by enzyme biocatalyzed reactions activated by sucrose, maltose and phosphate...
  17. ncbi Deoxyribozyme-based three-input logic gates and construction of a molecular full adder
    Harvey Lederman
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, Columbia University, Box 84, 630 West 168th Street, New York, New York 10032, USA
    Biochemistry 45:1194-9. 2006
    We have developed an array of seven deoxyribozyme-based molecular logic gates that behaves as a full adder in a single solution, with three oligonucleotides as inputs and two independent fluorogenic cleavage reactions as carry and sum ..
  18. pmc Vertically stacked multi-heterostructures of layered materials for logic transistors and complementary inverters
    Woo Jong Yu
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA
    Nat Mater 12:246-52. 2013
    ..interest for future electronics, but the absence of a bandgap limits its direct applicability in transistors and logic devices...
  19. ncbi Deoxyribozyme-based ligase logic gates and their initial circuits
    Milan N Stojanovic
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, Columbia University, Box 84, 630 West 168th Street, New York, NY 10032, USA
    J Am Chem Soc 127:6914-5. 2005
    A complete set (YES, NOT, AND, and ANDNOT) of molecular scale logic gates based on ligase deoxyribozymes was constructed...
  20. ncbi Does opposition logic provide evidence for conscious and unconscious processes in artificial grammar learning?
    Richard J Tunney
    University College London, Gower Street, London WCIE 6BT, UK
    Conscious Cogn 12:201-18. 2003
    ..Much of this controversy arises from the use of the logic of dissociation...
  21. pmc Intelligent medical diagnostics via molecular logic
    Tania Konry
    Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, USA
    J Am Chem Soc 131:13232-3. 2009
    In this communication, we describe the integration of microarray sensor technology with logic capability for screening combinations of proteins and DNA in a biological sample...
  22. ncbi Deoxyribozyme-based logic gates
    Milan N Stojanovic
    Division of Clinical Pharmacology and Experimental Therapeutics, Department of Medicine, Columbia University, New York 10032, USA
    J Am Chem Soc 124:3555-61. 2002
    We report herein a set of deoxyribozyme-based logic gates capable of generating any Boolean function. We construct basic NOT and AND gates, followed by the more complex XOR gate...
  23. ncbi The logic of reprobation: assessment and action rules for indirect reciprocation
    Hannelore Brandt
    Fakultät für Mathematik, Nordbergstrasse 15, 1090 Wien, Austria
    J Theor Biol 231:475-86. 2004
    ..The model presented here is based on three specifications: each player has a personal list of images of all co-players, a specific way of judging an observed situation, and a specific strategy to decide whether to cooperate or not...
  24. ncbi Development of a software tool using deterministic logic for the optimization of cochlear implant processor programming
    Paul J Govaerts
    The Eargroup, University of Antwerp, Antwerp Deurne, Belgium
    Otol Neurotol 31:908-18. 2010
    ..An intelligent agent, Fitting to Outcomes eXpert, was developed to optimize and automate Cochlear implant (CI) programming. The current article describes the rationale, development, and features of this tool...
  25. pmc Bio-logic builder: a non-technical tool for building dynamical, qualitative models
    Tomás Helikar
    Department of Mathematics, University of Nebraska at Omaha, Omaha, Nebraska, USA
    PLoS ONE 7:e46417. 2012
    ..To help address this issue, we have developed a web-based tool, Bio-Logic Builder, that enables laboratory scientists to define mathematical representations (based on a discrete formalism) ..
  26. ncbi Multiplexed aptasensors and amplified DNA sensors using functionalized graphene oxide: application for logic gate operations
    Xiaoqing Liu
    Institute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    ACS Nano 6:3553-63. 2012
    ..detection of DNA, aptamer-substrate complexes, and for the integration of predesigned DNA constructs that activate logic gate operations...
  27. pmc Exhaustively characterizing feasible logic models of a signaling network using Answer Set Programming
    Carito Guziolowski
    Ecole Centrale de Nantes, IRCCyN UMR CNRS 6597, 44321, Nantes, France
    Bioinformatics 29:2320-6. 2013
    b>Logic modeling is a useful tool to study signal transduction across multiple pathways. Logic models can be generated by training a network containing the prior knowledge to phospho-proteomics data...
  28. pmc Oscillatory threshold logic
    Jon Borresen
    School of Computing, Mathematics and Digital Technology, Manchester Metropolitan University, Manchester, United Kingdom
    PLoS ONE 7:e48498. 2012
    ..Here, we demonstrate how coupled threshold oscillators may be used to perform binary logic in a manner entirely consistent with modern computer architectures...
  29. ncbi Ion-tuned DNA/Ag fluorescent nanoclusters as versatile logic device
    Tao Li
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China
    ACS Nano 5:6334-8. 2011
    A novel kind of versatile logic device has been constructed utilizing ion-tuned DNA/Ag fluorescent nanoclusters, with K(+) and H(+) as two inputs...
  30. pmc Phylogenetically informed logic relationships improve detection of biological network organization
    Jike Cui
    Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA
    BMC Bioinformatics 12:476. 2011
    ..Despite this success, few studies have attempted to search beyond just pairwise relationships among genes. Here we search for logic relationships involving three genes, and explore its potential application in gene network analyses.
  31. ncbi Program theory evaluation: Logic analysis
    Astrid Brousselle
    Department of Community Health Sciences, Charles LeMoyne Hospital Research Center, University of Sherbrooke, Canada
    Eval Program Plann 34:69-78. 2011
    ..This article describes a particular type of program theory evaluation-logic analysis-that allows us to test the plausibility of a program's theory using scientific knowledge...
  32. ncbi Theory-based causal induction
    Thomas L Griffiths
    Department of Psychology, University of California, Berkeley, CA 94720 1650, USA
    Psychol Rev 116:661-716. 2009
    ....
  33. ncbi Conditionals: a theory of meaning, pragmatics, and inference
    P N Johnson-Laird
    Department of Psychology, Princeton University, New Jersey 08544, USA
    Psychol Rev 109:646-78. 2002
    ..Reasoners tend to focus on the explicit possibilities. The theory predicts the major phenomena of understanding and reasoning with conditionals...
  34. ncbi A noise-assisted reprogrammable nanomechanical logic gate
    Diego N Guerra
    Department of Physics, Boston University, Boston, Massachusetts 02215, USA
    Nano Lett 10:1168-71. 2010
    We present a nanomechanical device, operating as a reprogrammable logic gate, and performing fundamental logic functions such as AND/OR and NAND/NOR. The logic function can be programmed (e.g...
  35. pmc Mathematical logic in the human brain: syntax
    Roland Friedrich
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    PLoS ONE 4:e5599. 2009
    ..This seems to imply that despite structural analogies of common and current formal languages, at the neural level, mathematics and natural language are processed differently, in principal...
  36. ncbi DNA strand displacement system running logic programs
    Alfonso Rodriguez-Paton
    Departamento de Inteligencia Artificial, Facultad de Informatica, Universidad Politecnica de Madrid, Campus de Montegancedo s n, Boadilla del Monte, 28660 Madrid, Spain Electronic address
    Biosystems 115:5-12. 2014
    ..The model allows to run logic programs composed of Horn clauses by cascading resolution steps...
  37. ncbi Aptamer-controlled biofuel cells in logic systems and used as self-powered and intelligent logic aptasensors
    Ming Zhou
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People s Republic of China
    J Am Chem Soc 132:2172-4. 2010
    This communication demonstrates for the first time the controlled power release of biofuel cells (BFCs) by aptamer logic systems processed according to the Boolean logic operations "programmed" into the biocomputing systems...
  38. ncbi The logic of the stimulus
    Stephen E G Lea
    School of Psychology, Washington Singer Laboratories, University of Exeter, Exeter, EX4 4QG, United Kingdom
    Anim Cogn 9:247-56. 2006
    ..and cognition), stimuli provide the raw material to which the organism applies its cognitive processes-its logic, which may be taxon-specific...
  39. ncbi Development of a program logic model to measure the processes and outcomes of a nurse-managed community health clinic
    Margaret Dykeman
    University of New Brunswick, Fredericton, Canada
    J Prof Nurs 19:197-203. 2003
    ..The program logic model was chosen and modified to guide evaluation...
  40. pmc The logic of indirect speech
    Steven Pinker
    Department of Psychology, and Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:833-8. 2008
    ..This feature makes an indirect request qualitatively different from a direct one even when the speaker and listener can infer each other's intentions with high confidence...
  41. pmc Synthesizing biomolecule-based Boolean logic gates
    Takafumi Miyamoto
    Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD 21205, USA
    ACS Synth Biol 2:72-82. 2013
    ..The main components of a computing device consist of an arithmetic logic unit, the control unit, memory, and the input and output devices...
  42. pmc Markov logic networks in the analysis of genetic data
    Nikita A Sakhanenko
    Institute for Systems Biology, Seattle, Washington 98103, USA
    J Comput Biol 17:1491-508. 2010
    ..We chose to use the most general such approach, Markov Logic Networks (MLNs), for combining deterministic knowledge with statistical analysis...
  43. ncbi Biofuel cell controlled by enzyme logic systems
    Liron Amir
    Department of Chemistry and Biomolecular Science, and NanoBio Laboratory, Clarkson University, Potsdam, New York 13699 5810, USA
    J Am Chem Soc 131:826-32. 2009
    An enzyme-based biofuel cell with a pH-switchable oxygen electrode, controlled by enzyme logic operations processing in situ biochemical input signals, has been developed...
  44. ncbi Designable DNA-binding domains enable construction of logic circuits in mammalian cells
    Rok Gaber
    1 Department of Biotechnology, National Institute of Chemistry, Ljubljana, Slovenia 2 EN FIST Centre of Excellence, Ljubljana, Slovenia 3
    Nat Chem Biol 10:203-8. 2014
    Electronic computer circuits consisting of a large number of connected logic gates of the same type, such as NOR, can be easily fabricated and can implement any logic function...
  45. ncbi Logic, language and the brain
    Martin M Monti
    Department of Psychology, University of California Los Angeles, USA
    Brain Res 1428:33-42. 2012
    ..These representations are then manipulated by mental operations that are not based on the neural mechanisms of natural language. This article is part of a Special Issue entitled "The Cognitive Neuroscience"...
  46. ncbi Distinguishing logic from association in the solution of an invisible displacement task by children (Homo sapiens) and dogs (Canis familiaris): using negation of disjunction
    J S Watson
    Psychology Department, University of California, Berkeley 94720, USA
    J Comp Psychol 115:219-26. 2001
    ..Using the role of negation in logic whereby negative feedback about one belief increases the certainty of another (e.g...
  47. pmc Gene function hypotheses for the Campylobacter jejuni glycome generated by a logic-based approach
    Michael J E Sternberg
    Centre for Integrative Systems Biology, Imperial College London, London SW7 2AZ, UK
    J Mol Biol 425:186-97. 2013
    ..Here, we demonstrate the power of a logic-based machine learning approach to propose hypotheses for gene function integrating information from two diverse ..
  48. ncbi Specification and misspecification of theoretical foundations and logic models for health communication campaigns
    Michael D Slater
    School of Communication, The Ohio State University, Columbus, 43210, USA
    Health Commun 20:149-57. 2006
    ..Otherwise, strategic errors in message design and dissemination, and misspecified campaign logic models, insensitive to campaign effects, are likely to result...
  49. ncbi Children value informativity over logic in word learning
    Michael Ramscar
    Department of Linguistics, University of Tubingen, Germany
    Psychol Sci 24:1017-23. 2013
    ..Adults adopted a markedly different and likely suboptimal strategy. These results suggest one explanation for why early word learning can appear baffling: Adult intuitions may be a poor source of insight into how children learn...
  50. ncbi Design of synthetic biological logic circuits based on evolutionary algorithm
    Chia Hua Chuang
    Department of Electrical Engineering, National Chung Hsing University, Taichung, Taiwan
    IET Syst Biol 7:89-105. 2013
    The construction of an artificial biological logic circuit using systematic strategy is recognised as one of the most important topics for the development of synthetic biology...
  51. ncbi When logic fails: implicit transitive inference in humans
    Michael J Frank
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    Mem Cognit 33:742-50. 2005
    ..In this account, choice performance is based on differential associative strengths across the stimulus items that develop over training, despite equal overt reinforcement...
  52. ncbi Logic in an asymmetrical (social) brain: Transitive inference in the young domestic chick
    Jonathan Niall Daisley
    Department of General Psychology, University of Padova, Padova, Italy
    Soc Neurosci 5:309-19. 2010
    ..Results demonstrate that chicks with lateralized brain hemispheres show greater inference, and this is under right hemisphere control: the brain hemisphere that is dominant in social interactions...
  53. ncbi DNA logic gates
    Akimitsu Okamoto
    Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, Kyoto 615 8510, Japan
    J Am Chem Soc 126:9458-63. 2004
    A conceptually new logic gate based on DNA has been devised. Methoxybenzodeazaadenine ((MD)A), an artificial nucleobase which we recently developed for efficient hole transport through DNA, formed stable base pairs with T and C...
  54. pmc Logic reversibility and thermodynamic irreversibility demonstrated by DNAzyme-based Toffoli and Fredkin logic gates
    Ron Orbach
    Institute of Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 109:21228-33. 2012
    The Toffoli and Fredkin gates were suggested as a means to exhibit logic reversibility and thereby reduce energy dissipation associated with logic operations in dense computing circuits...
  55. pmc Self-confirming "AND" logic nanoparticles for fault-free MRI
    Jin sil Choi
    Department of Chemistry, Yonsei University, Seoul 120 749, Korea
    J Am Chem Soc 132:11015-7. 2010
    ..This DMCA not only possesses superior MR contrast effects but also has the unique capability of displaying "AND" logic signals in both the T1 and T2 modes...
  56. ncbi Disseminating medical knowledge: the PROforma approach
    J Fox
    Imperial Cancer Research Fund, London, UK
    Artif Intell Med 14:157-81. 1998
    ..This paper provides a description of the language and associated software tools, and discusses its potential roles in, and implications for, medical knowledge publishing...
  57. ncbi Programmable logic controller implementation of an auto-tuned predictive control based on minimal plant information
    G Valencia-Palomo
    Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, South Yorkshire, S1 3JD, UK
    ISA Trans 50:92-100. 2011
    ..Hence, it describes how the constrained control algorithm is embedded in an industrial programmable logic controller (PLC) using the IEC 61131-3 programming standard...
  58. doi Life, logic and information
    Paul Nurse
    Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 454:424-6. 2008
  59. ncbi Implementing an OR-NOT (ORN) logic gate with components of the SOS regulatory network of Escherichia coli
    Rafael Silva-Rocha
    Systems and Synthetic Biology Program, Centro Nacional de Biotecnologia CSIC, Madrid, Spain
    Mol Biosyst 7:2389-96. 2011
    Whether biological or electronic, man-engineered computation is based on logic circuits assembled with binary gates that are interconnected to perform Boolean operations...
  60. ncbi Using a program logic model that focuses on performance measurement to develop a program
    J J Dwyer
    Education and Research Division, North York Public Health Department, ON
    Can J Public Health 88:421-5. 1997
    A program logic model is used to make a program ready for an evaluation. It diagrammatically shows the relationships between the objectives of the program, program activities, indicators, and resources...
  61. pmc A discriminative method for family-based protein remote homology detection that combines inductive logic programming and propositional models
    Juliana S Bernardes
    COPPE, Programa de Engenharia de Sistemas e Computacao, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    BMC Bioinformatics 12:83. 2011
    ..From this, Inductive Logic Programming (ILP) finds the most frequent patterns (motifs) and uses them to train propositional models, such as ..
  62. pmc Syntax, concepts, and logic in the temporal dynamics of language comprehension: evidence from event-related potentials
    Karsten Steinhauer
    McGill University, Centre for Research on Language, Mind and Brain, and School of, Communication Sciences and Disorders, USA
    Neuropsychologia 48:1525-42. 2010
    b>Logic has been intertwined with the study of language and meaning since antiquity, and such connections persist in present day research in linguistic theory (formal semantics) and cognitive psychology (e.g., studies of human reasoning)...
  63. ncbi A selenophene-based low-bandgap donor-acceptor polymer leading to fast ambipolar logic
    Auke J Kronemeijer
    Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge, UK
    Adv Mater 24:1558-65. 2012
    Fast ambipolar CMOS-like logic is demonstrated using a new selenophene-based donor-acceptor polymer semiconductor. The polymer exhibits saturation hole and electron mobilities of 0.46 cm(2) /Vs and 0.84 cm(2) /Vs...
  64. pmc A logic model framework for evaluation and planning in a primary care practice-based research network (PBRN)
    Holly Hayes
    Department of Family and Community Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    J Am Board Fam Med 24:576-82. 2011
    ..The purpose of this article is to describe the development of a logic model and how the framework has been used for planning and evaluation in a primary care PBRN...
  65. ncbi Crystal violet as a fluorescent switch-on probe for i-motif: label-free DNA-based logic gate
    Dik Lung Ma
    Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    Analyst 136:2692-6. 2011
    The first application of crystal violet as a selective fluorescent switch-on probe for i-motif DNA has been reported. This interaction has been exploited to develop a label-free DNA-based "OR" logic gate for potassium and hydrogen ions.
  66. pmc "Antelope": a hybrid-logic model checker for branching-time Boolean GRN analysis
    Gustavo Arellano
    Instituto de Investigaciones en Matematicas Aplicadas y en Sistemas, Universidad Nacional Autonoma de Mexico, 01000 Mexico D F, Mexico
    BMC Bioinformatics 12:490. 2011
    ..Model checkers for branching time, by contrast, are able to prove properties in the presence of infinitely many paths...
  67. ncbi Mental model construction in linear reasoning: evidence for the construction of initial annotated models
    Andre Vandierendonck
    Department of Experimental Psychology, Ghent University, Henri Dunantlaan 2, B 9000 Ghent, Belgium
    Q J Exp Psychol A 57:1369-91. 2004
    ..Implications of these findings for the mental model theory as developed for relational reasoning are discussed...
  68. ncbi Molecular-scale logic gates
    A Prasanna de Silva
    School of Chemistry, Queen s University, Belfast BT9 5AG, UK
    Chemistry 10:574-86. 2004
    Currently available approaches to molecular-scale logic gates are summarized and compared...
  69. pmc Formidability and the logic of human anger
    Aaron Sell
    Center for Evolutionary Psychology, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 106:15073-8. 2009
    ..stronger men favored greater use of military force in international conflicts provides evidence that the internal logic of the anger program reflects the ancestral payoffs characteristic of a small-scale social world rather than ..
  70. ncbi Developing a practice-academic partnership logic model
    Maura MacPhee
    University of British Columbia, School of Nursing, Vancouver, British Columbia, Canada
    Nurs Outlook 57:143-7. 2009
    This article will describe a testable logic model for practice-academic partnerships. The model can be used to build collaborative practice capacity between academic and practice partners...
  71. ncbi Working memory constraints on linear reasoning with spatial and temporal contents
    A Vandierendonck
    Department of Experimental Psychology, University of Ghent, Belgium
    Q J Exp Psychol A 50:803-20. 1997
    ..The implications of the data for the working memory requirements of reasoning and for theories of linear reasoning are discussed...
  72. ncbi Multiplexing and demultiplexing logic functions for computing signal processing tasks in synthetic biology
    Lorenzo Pasotti
    Dipartimento di Informatica e Sistemistica, Universita degli Studi di Pavia, Pavia, Italy
    Biotechnol J 6:784-95. 2011
    ..Herein, two modular biological systems that could mimic multiplexing and demultiplexing logic functions are proposed and discussed...
  73. ncbi Reasoning about relations
    Geoffrey P Goodwin
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Psychol Rev 112:468-93. 2005
    ..The article describes computer implementations of the theory and presents experimental results corroborating its main principle...
  74. ncbi Illusory inferences: a novel class of erroneous deductions
    P N Johnson-Laird
    Department of Psychology, Princeton University, NJ 08544 1010, USA
    Cognition 71:191-229. 1999
    ..Three experiments corroborated the systematic occurrence of these illusory inferences, and eliminated a number of alternative explanations for them. Their results illuminate the controversy among various current theories of reasoning...
  75. ncbi Illusions in reasoning about consistency
    P N Johnson-Laird
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Science 288:531-2. 2000
    ..This procedure avoids overloading memory, but it yields illusions of consistency and of inconsistency. These illusions modify our picture of human rationality...
  76. ncbi Essay: the political logic of regulatory error
    Daniel Carpenter
    Department of Government, 1737 Cambridge St, CGIS N405, Harvard University, Cambridge, Massachusetts 02138, USA
    Nat Rev Drug Discov 4:819-23. 2005
    ..Here, we provide a theoretical discussion of the factors that could influence regulatory error, drawing on the Vioxx episode in particular as a possible example of error, and consider the implications for future regulatory policy...
  77. ncbi The phenogenetic logic of life
    Kenneth M Weiss
    Department of Anthropology, 409 Carpenter Building, University Park, Penn State University, Pennsylvania 16802, USA
    Nat Rev Genet 6:36-45. 2005
    ..Advances in recent decades have opened the way for an understanding of the phenogenetic logic or relational principles of life, by which a few basic characteristics of genomes produce biological phenotypes ..
  78. ncbi Biochemical filter with sigmoidal response: increasing the complexity of biomolecular logic
    Vladimir Privman
    Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, New York 13699, USA
    J Phys Chem B 114:14103-9. 2010
    ..process is reported and analyzed as a promising network component for increasing the complexity of biomolecular logic systems. Key challenge in biochemical logic research has been achieving scalability for complex network designs...
  79. pmc Label-free, dual-analyte electrochemical biosensors: a new class of molecular-electronic logic gates
    Fan Xia
    Center for Polymers and Organic Solids, University of California, Santa Barbara, California 93106, USA
    J Am Chem Soc 132:8557-9. 2010
    An "XOR" gate built using label-free, dual-analyte electrochemical sensors and the activation of this logic gate via changing concentrations of cocaine and the relevant cDNA as inputs are described.
  80. ncbi Optimal data selection: revision, review, and reevaluation
    Mike Oaksford
    School of Psychology, Cardiff University, Cardiff, Wales
    Psychon Bull Rev 10:289-318. 2003
    ..Consequently, the conclusion of Oaksford and Chater's (1994) original rational analysis (Anderson, 1990), that people's hypothesis-testing behavior on this task is rational and well adapted to the environment, still stands...
  81. ncbi Probabilistic and fuzzy logic in clinical diagnosis
    G Licata
    Department of Clinical Neurosciences, University of Palermo, Via Catania 166, I 90141, Palermo, Italy
    Intern Emerg Med 2:100-6. 2007
    In this study I have compared classic and fuzzy logic and their usefulness in clinical diagnosis...
  82. ncbi An investigation of learning strategy supporting transitive inference performance in humans compared to other species
    Sandra N Moses
    Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Canada
    Neuropsychologia 44:1370-87. 2006
    ..a hallmark of logical reasoning, can be solved by non-human species via associative learning rather than logic. We tested whether humans use similar strategies to other species for transitive inference...
  83. ncbi Helping students learn to think like experts when solving clinical problems
    H Mandin
    Department of Medicine, University of Calgary Faculty of Medicine, Alberta, Canada
    Acad Med 72:173-9. 1997
    ..The "hypothetico-deductive" strategy traditionally used in PBL should be replaced by scheme-driven search strategies so that students develop a more organized and logical approach to problem solving...
  84. ncbi Fuzzy Logic in neurosurgery: predicting poor outcomes after lumbar disk surgery in 501 consecutive patients
    Muhammad Shahzad Shamim
    Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, P O Box 3500, Stadium Road, Karachi 74800, Pakistan
    Surg Neurol 72:565-72; discussion 572. 2009
    ..We have used Fuzzy Logic-based fuzzy inference system (FIS) for identifying patients unlikely to improve after disk surgery and explored ..
  85. ncbi Microfluidic bubble logic
    Manu Prakash
    Center for Bits and Atoms, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 315:832-5. 2007
    ..We demonstrate bubble logic AND/OR/NOT gates, a toggle flip-flop, a ripple counter, timing restoration, a ring oscillator, and an electro-..
  86. ncbi Medical knowledge reengineering--converting major portions of the UMLS into a terminological knowledge base
    S Schulz
    Freiburg University Hospital, Department of Medical Informatics, Stefan Meier Strasse 26, D 79104 Freiburg, Germany
    Int J Med Inform 64:207-21. 2001
    ....
  87. ncbi Are children with Specific Language Impairment competent with the pragmatics and logic of quantification?
    Napoleon Katsos
    Research Centre for English and Applied Linguistics, University of Cambridge, United Kingdom
    Cognition 119:43-57. 2011
    ..The implications of these findings for SLI, linguistic theory, and clinical practice are discussed...
  88. ncbi Algorithm of myogenic differentiation in higher-order organisms
    Ron Piran
    Schulich Faculty of Chemistry, Technion Israel Institute of Technology, Technion City, Haifa 32000, Israel
    Development 136:3831-40. 2009
    ..Specifically, we applied the Łukasiewicz logic to a diffusible protein system that leads to myogenesis...
  89. ncbi Real-time supervisor system based on trinary logic to control experiments with behaving animals and humans
    D F Kutz
    Dipartimento di Fisiologia Umana e Generale, Univerità di Bologna, Piazza Porta San Donato 2, 40126 Bologna, Italy
    J Neurophysiol 93:3674-86. 2005
    A new method is presented based on trinary logic able to check the state of different control variables and synchronously record the physiological and behavioral data of behaving animals and humans...
  90. ncbi The story of some: everyday pragmatic inference by children and adults
    Aidan Feeney
    Applied Psychology, University of Durham, Thornaby, Stockton on Tees, UK
    Can J Exp Psychol 58:121-32. 2004
    ..These results suggest that some adults develop the ability to inhibit a pragmatic response in favour of a logical answer. We discuss the implications of these findings for theories of pragmatic inference...
  91. ncbi Semibiological molecular machine with an implemented "AND" logic gate for regulation of protein folding
    Shinichi Muramatsu
    Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    J Am Chem Soc 128:3764-9. 2006
    A semibiological molecular machine with an implemented "AND" logic gate was developed, which was capable of controlling the folding process of proteins in response to ATP and light as input stimuli...
  92. ncbi Cellular logic with orthogonal ribosomes
    Oliver Rackham
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Am Chem Soc 127:17584-5. 2005
    ..unnatural molecules (orthogonal ribosomes) can be used combinatorially, in a single cell, to program Boolean logic functions...
  93. pmc A logic model for the integration of mental health into chronic disease prevention and health promotion
    James Lando
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mail Stop K 40, Atlanta, GA 30341, USA
    Prev Chronic Dis 3:A61. 2006
    ..A group of mental health and public health professionals convened to develop a logic model for addressing mental health as it relates to chronic disease prevention and health promotion...
  94. ncbi A formal theory for spatial representation and reasoning in biomedical ontologies
    Maureen Donnelly
    Department of Philosophy, New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, 135 Park Hall, Buffalo, NY 14260, USA
    Artif Intell Med 36:1-27. 2006
    ....
  95. ncbi Process chemistry: The science, business, logic, and logistics
    Tony Y Zhang
    Chemical Product R and D, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Chem Rev 106:2583-95. 2006
  96. ncbi Part-whole representation and reasoning in formal biomedical ontologies
    Stefan Schulz
    Department of Medical Informatics, Freiburg University Hospital, Stefan Meier Str 26, D 79104 Freiburg, Germany
    Artif Intell Med 34:179-200. 2005
    ..For the biomedical domain, it is not only crucial to cope with ontological dependencies between wholes and their parts but also with specific reasoning patterns which underlie the propagation of roles across partonomic hierarchies...
  97. ncbi Programmable logic construction kits for hyper-real-time neuronal modeling
    Ruben Guerrero-Rivera
    Center for Bioengineering, University of Leicester, Leicester LE1 7RH, UK
    Neural Comput 18:2651-79. 2006
    Programmable logic designs are presented that achieve exact integration of leaky integrate-and-fire soma and dynamical synapse neuronal models and incorporate spike-time dependent plasticity and axonal delays...
  98. pmc Boolean logic functions of a synthetic peptide network
    Gonen Ashkenasy
    Departments of Chemistry and Molecular Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Am Chem Soc 126:11140-1. 2004
    ..A number of studies have adapted nucleic acids and proteins to the design of molecular logic gates and computational systems, while other works have affected computation in living cells via biochemical ..
  99. ncbi The role of awareness and working memory in human transitive inference
    M Libben
    Department of Psychology, McGill University, Stewart Biological Sciences Building, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada
    Behav Processes 77:43-54. 2008
    ..Both prior aware participants and serendipitously aware participants were more likely to engage in a logic-based strategy compared to unaware participants who relied upon stimulus-driven strategies...
  100. ncbi Kinetic logic: a tool for describing the dynamics of infectious disease behavior
    Claire Martinet-Edelist
    Virologie Moléculaire et Structurale, CNRS, 91198 Gif Yvette cedex, France
    J Cell Mol Med 8:269-81. 2004
    ..Kinetic logic, which is a method easily accessible to biologists or physicians, and which takes time and thresholds of activity ..
  101. ncbi Anatomy of deductive reasoning
    Vinod Goel
    Department of Psychology, York University, Toronto, M3J 1P3, Canada
    Trends Cogn Sci 11:435-41. 2007
    ..been preoccupied with advocating for or against visuospatial (mental model theory) or linguistic/syntactic (mental logic theory) models of logical reasoning...

Research Grants74

  1. Genetic variation and regulatory networks: Mechanisms and complexity
    DANA PE ER; Fiscal Year: 2009
    ..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
  2. Bone Deficits and Excess Adiposity after Pediatric Bone Marrow Transplantation
    Sogol Mostoufi-Moab; Fiscal Year: 2013
    ..Hematopoietic stem cell transplantation (HSCT) is an established treatment for benign and malignant hemato- logic diseases in children...
  3. Emergency Neurophysiological Assessment Bedside Logic Engine
    Don M Tucker; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Emergency Neurophysiological Assessment Bedside Logic Engine We propose to develop an intelligent clinical informatics search tool that is integrated with automated brain monitoring with dense array ..
  4. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..The developmental logic of the tracheal system is similar to that of the mammalian vascular system, where vascular sprouts expressing the ..
  5. Sphingosine 1-phosphate receptors in vascular homeostasis and pathology
    TIMOTHY TUN HLA; Fiscal Year: 2012
    ..The long-term goal of this research program is to better understand the logic of S1P signaling in the vasculature...
  6. Genome-wide measurement of bacterial transcriptional regulatory states
    Peter L Freddolino; Fiscal Year: 2013
    ..however, biologists are still bereft of a generally applicable method for rapid determination of the regulatory logic underlying the pattern of gene expression in a cell under a given set of conditions...
  7. Biosynthesis of Microbial Isoprenoids
    David E Cane; Fiscal Year: 2013
    ..platform for the discovery of new biochemical reactions and mechanisms, for the understanding of the molecular logic of natural product biosynthetic pathways, for the elucidation of the still obscure factors regulating expression ..
  8. The role of human DNA polymerase eta in the mutagenic response to oxidative stres
    SCOTT DAVID MCCULLOCH; Fiscal Year: 2013
    ..This allows the overall pol 7 dependent bypass reaction to suppress mutations caused by UV light. A similar logic has been proposed for the suppression of mutagenesis during pol 7 dependent bypass of 8-oxo-dG...
  9. Lab-on-a-chip for Neonatal Hyperbilirubinemia Screening
    Vijay Srinivasan; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Advanced Liquid Logic, Inc. is developing a lab-on-a-chip on its proprietary digital microfluidic platform for newborn screening...
  10. Function of Microtubule Plus-End-Tracking Proteins in the Neuronal Growth Cone
    Laura Anne Lowery; Fiscal Year: 2013
    ..at a research university and develop a comprehensive, multi-faceted research program that investigates the logic by which guidance information is integrated at the level of cytoskeletal dynamics during axon pathfinding...
  11. Regulation of Synapse Morphogenesis in Drosophila
    David L Van Vactor; Fiscal Year: 2013
    ..development, and a wonderful opportunity to exploit a powerful and well-defined model system to understand the logic of miRNA control over synapse form and function...
  12. REGULATORY INTERACTIONS BETWEEN TUMOR VIRUSES AND CELLS
    Michael R Botchan; Fiscal Year: 2013
    ..by signalling kinases, other proximal site-specific DNA factors and MMB composition together sen/e as ancf/or logic gates for function...
  13. Sound Source Segregation
    Mark A Bee; Fiscal Year: 2013
    ..Though seldom stated explicitly in hearing research, the logic of this biomimetic approach is based on evolutionary thinking: the aim is to understand how natural selection has ..
  14. Computer Simulation of Acute Coronary Syndrome Care in the Emergency Department
    DANIEL JOSEPH FRANCE; Fiscal Year: 2010
    ..These models will be programmed as functions into the applicable DES entity (i.e., patient, lab, X-ray, etc) flow logic to compute wait-time distributions for each care process interval (ED arrival-to-ECG, etc)...
  15. Regulation of BimEL phosphorylation in the pathogenesis of Huntington's disease
    Jianning Wei; Fiscal Year: 2012
    ..The current application is a logic extension of our research plan and aims to identify molecular causes for increased BimEL expression in two ..
  16. A Molecular Analysis of the Gateway Hypothesis in Mice
    Amir Levine; Fiscal Year: 2012
    ..Our approach is further based on the evidence that addiction shares molecular steps and molecular logic with long-term memory...
  17. Regulation of yeast cellular aging through chromatin and novel pathways
    Weiwei Dang; Fiscal Year: 2013
    ..deletion, has been a tremendously valuable resource for defining gene function, understanding the structure and logic of multiple cellular pathways, many of which are conserved from yeast to humans, and for identifying the target ..
  18. Role of msps and tacc during axon guidance
    LAURA A LOWERY; Fiscal Year: 2010
    ..My long-term goal is to define the logic by which guidance information is integrated at the level of cytoskeletal dynamics control during axon pathfinding...
  19. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith S Eisen; Fiscal Year: 2012
    ..To deduce the logic by which transcriptional modules regulate motoneuron development, we propose to knock down expression of specific ..
  20. GENETIC ANALYSIS OF PLEIOTROPIC DRUG RESISTANCE
    W Scott Moye-Rowley; Fiscal Year: 2013
    ..Understanding the logic used by a yeast cell to control the multidrug resistance will allow use of strategies to prevent this phenotype ..
  21. Purchase of a nanoLC-QTRAP Mass Spectrometer for Targeted Proteomics Studies
    Sonja Hess; Fiscal Year: 2013
    ..This analysis will provide insights into the molecular logic of this key regulatory system which has been implicated in the pathogenesis of cancer...
  22. Taste Receptor Genes and Sensory Coding
    HUBERT O AMREIN; Fiscal Year: 2013
    ..Its role has been of particular significance in uncovering the logic of chemosensory perception, because its chemosensory systems exhibit many parallels with those of vertebrates/..
  23. Genomic targets of oncoproteins and tumor suppressors
    Kevin Struhl; Fiscal Year: 2013
    ..Third, using the same logic and experimental approaches, we will identify genes, microRNAs, and regulatory pathways involved in the generation ..
  24. INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAM
    David G Schatz; Fiscal Year: 2013
    ..Both predoctoral and postdoctoral training are enriched by intensive training in the methods, logic, and responsible conduct of research, and by the many opportunities for collaboration and interaction...
  25. NMR studies of heterocyclization and epimerization in yersiniabactin synthesis
    DOMINIQUE PASCAL FRUEH; Fiscal Year: 2013
    ..coli, responsible for urinary tract infections. Our results will contribute to understanding the molecular logic employed by these pathogens during infections...
  26. Use of Silver Nanostructures on Microtransponders in Ultra-sensitive Assay
    Wlodek Mandecki; Fiscal Year: 2011
    ..Each chip consists of photocells, read-only memory (ROM), transmit logic circuitry, and an integrated antenna which, when illuminated, transmit an ID through a varying magnetic field...
  27. Analysis of a Large Family of Candidate Taste Receptors
    John R Carlson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The long-term goal of this project is to reveal the logic by which tastants are encoded, and to elucidate basic principles of the organization and development of the neurons that encode them...
  28. FORMATION OF THE DROSOPHILA SALIVARY GLAND
    Deborah J Andrew; Fiscal Year: 2013
    ..and their targets are an excellent toolset for revealing the details of morphogenesis and the regulatory logic linking morphogenesis to functional specialization...
  29. Epithelial-mesenchymal interactions in facial patterning
    GAGE D CRUMP; Fiscal Year: 2013
    ..The long-term goal of this proposal is to understand the logic by which arch mesenchymal cells interpret diverse signals in their environment to develop into precisely shaped ..
  30. EPIDEMIOLOGY OF SURFACTANT PROTEIN-B DEFICIENCY
    FRANCIS SESSIONS COLE; Fiscal Year: 2013
    ..and gene x environment interactions that confer disease risk, we will use exonic sequencing and CMC, Bayesian, and logic tree statistical methods in replication and merged case-control cohorts...
  31. Emergence of developmental and genomic complexity in a basal vertebrate
    Marianne Bronner; Fiscal Year: 2013
    ..set of experiments that further define the developmental role of VLRs and elucidate the early VLR repertoire and logic by which the embryonic genomic rearrangements occur at the VLR locus...
  32. Engineering of computational receptors and gene circuits for T-cell immunotherapy
    YVONNE YU HSUAN CHEN; Fiscal Year: 2013
    ..These inducible transcription systems will be combined with the logic-gate CARs developed in Specific Aim 1 to generate tumor-targeting T cells capable of both executing and recruiting ..
  33. "Understanding Complex Gene Editing Systems in Protists"
    Laura F Landweber; Fiscal Year: 2013
    ..The proposed research combines different approaches that together focus on the mechanism and underlying logic of massive genome reorganization in ciliates, over a range of scales, from single gene functional experiments to ..
  34. SURFACTANT PATHWAY GENE VARIANTS AMONG INFANTS WITH RESPIRATORY DISTRESS SYNDROME
    JENNIFER WAMBACH; Fiscal Year: 2013
    ..algorithms to assess variant functionality, use traditional (regression) and novel (Collapsing Methods, BimBam, logic regression) statistical approaches to evaluate variant interactions, and use cell-based assays to study the ..
  35. Staying Off Substances: A Tailored Early Recovery Program for Teens
    KIMBERLEE JEAN TRUDEAU; Fiscal Year: 2012
    ..and an individualized user experience because CHAT(R): SOS will utilize an innovative content management and logic solution called Ektron...
  36. Multiplex platform for point of care newborn screening of hyperbilirubinemia
    NICHOLAS TROTTA; Fiscal Year: 2013
    ..Advanced Liquid Logic's digital microfluidic platform is a recognized innovative, low-cost, automated microdroplet-based liquid ..
  37. Assembly of the Central Olfactory Networks in Drosophila
    Liqun Luo; Fiscal Year: 2013
    ..completion of the proposed experiments in this grant will significantly enrich and expand our understanding of the logic and mechanisms of olfactory circuit assembly...
  38. Naive T cell homeostasis: Treg selection and survival
    Christophe O Benoist; Fiscal Year: 2013
    ..In a reversion of the usual experimental logic, we will use single-cell TCR sequencing and construction of retrogenic mice to test, not whether a given cell can ..
  39. Broad spectrum therapeutics that target the viral membrane
    Benhur Lee; Fiscal Year: 2012
    ..our lead compound that has broad spectrum antiviral activity against enveloped viruses, and uses an experimental logic model that re-iteratively hones in on improving its in vivo efficacy in animal challenge experiments...
  40. Molecular Mechanisms of Semaphorin/Plexin-mediated Cytoskeletal Reorganization
    Jonathan R Terman; Fiscal Year: 2013
    ..These new results provide an underlying logic through which Sema- mediated reorganizations of the actin cytoskeleton can be precisely achieved in space and time:..
  41. Amorphous computation with transcription logic gates
    Andrew D Ellington; Fiscal Year: 2013
    ..amorphous computations, we have modeled and are beginning to build two-dimensional arrays of transcriptional logic gates...
  42. Deciphering the gene regulatory network controlling vertebrate endodermal fates
    Aaron M Zorn; Fiscal Year: 2013
    ..are needed to generate a GRN with predictive power and to gain a systems-level understanding of the regulatory logic controlling endoderm development...
  43. Selective Regulation of Pro-inflammatory Genes in Macrophages
    Stephen T Smale; Fiscal Year: 2013
    ..of immune and inflammatory responses, a major current objective is to uncover the molecular mechanisms and overall logic by which a robust transcriptional response is orchestrated...
  44. CSHL Watson School of Biological Sciences
    Alexander Gann; Fiscal Year: 2013
    ..work and laboratory rotations in separate phases, (iv) emphasis on the principles of scientific reasoning and logic as well as the importance of ethics and effective communication, (v) continued advanced course instruction ..
  45. Structure and Function in Notch Signaling
    Stephen C Blacklow; Fiscal Year: 2013
    ..The overarching goal of these studies is to elucidate the molecular logic of Notch signaling in different developmental, physiologic, and pathophysiologic contexts...
  46. Defining the Logic of Neurovascular Signaling in the Brain
    David Kleinfeld; Fiscal Year: 2013
    ..Such a model will clarify neurovascular disease models and neuroimaging studies. ..
  47. Single-cell analysis of TNF-induced signaling, transcription and fate decisions
    Suzanne Gaudet; Fiscal Year: 2013
    ..2. Decode the logic by which cells integrate intracellular signals and external context to commit to a TNF- induced cell fate...
  48. Two Phase Approach to Pancreatic Islet Transplantation
    BHUPINDER SINGH SHERGILL; Fiscal Year: 2013
    ..b>Logic dictates that a pre- vascularized tissue should solve these problems...
  49. Structural studies of substrate recognition and specificity by the SCF ubiquitin
    Bing Hao; Fiscal Year: 2013
    ..In this project we aim to delineat the structural mechanisms and molecular logic underlying the selectivity of Fbx4 and Fbxo31 towards their respective substrates cyclin D1 and TRF1...
  50. Identification of novel therapeutics for tuberculosis combining cheminformatics,
    Sean Ekins; Fiscal Year: 2013
    ..entitled "Identification of novel therapeutics for tuberculosis combining cheminformatics, diverse databases and logic-based pathway analysis" describes the development of software that will facilitate new drug discovery efforts for ..
  51. Analysis of Chemosensory Receptor Genes
    John R Carlson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The long-term goal of this project is to explain the logic by which chemical signals are encoded, and to elucidate basic principles of the organization and development of the neurons that encode them...
  52. Defining the Logic of Neurovascular Signaling in the Brain
    David Kleinfeld; Fiscal Year: 2011
    DESCRIPTION Abstract: Defining the Logic of Neurovascular Signaling in the Brain Blood is a vital and limited resource in the brain: neuronal activity requires supplies of oxygen and glucose, and deprivation of flow to even restricted ..
  53. Rapid point of care HIV PCR diagnostic device
    JOHN CHARLES GERDES; Fiscal Year: 2010
    ..RNA is extracted from a whole blood finger or heel stick (20-50 microliter) specimen using fluidic and valve logic within a tooled cartridge device and the eluted nucleic acid introduced directly into microchannels for cDNA ..
  54. The role of octopamine receptor-expressing neurons in aggression.
    ERIC DOMINGUEZ HOOPFER; Fiscal Year: 2012
    SPACE PROVIDED. Research Summary: The major goal of this research proposal is to understand the logic that governs how neural circuits give rise to complex behaviors...
  55. Adenylyl cyclase isoforms in hypertrophy and heart failure
    Stephen F Vatner; Fiscal Year: 2013
    ..which have the greatest impact on Public Health in the US, in terms of finances and task- force, and using similar logic, finding new therapies will be crucial to minimize the impact of these disease states on Public Health...
  56. Discovery and Targeting of West Nile Virus Epitopes
    William Hildebrand; Fiscal Year: 2013
    ..The development of mAb to WNV/HLA complexes in aim 2 will proceed through collaboration with Receptor Logic, a biotech firm proficient in the production of mAb to HLA/peptide complexes...
  57. PGT Inhibitors Mapped From a Tunicamycin Blueprint
    Barbara Imperiali; Fiscal Year: 2013
    ..The central theme of the research approach relies on exploiting the molecular logic of the natural product nucleoside antibiotics, in particular tunicamycin, as a "blue print" for the structure-..
  58. Elucidating the role of cis-regulatory logic in photoreceptor diversification
    Jennifer Enright; Fiscal Year: 2013
    ..Exploring these mechanisms in avian photoreceptors will provide critical insights into CNS diversification and advance the development of novel therapies for retinal disease. ..
  59. PKC EPSILON AND SRC PTK SIGNALING IN PRECONDITIONING
    Peipei Ping; Fiscal Year: 2013
    ..Aim 3 is a logic next step of Aim 2...
  60. Point-of-Care Nucleic Acid Test for Cytomegalovirus for Newborn Hearing Screening
    Vamsee K Pamula; Fiscal Year: 2013
    ..Advanced Liquid Logic's digital microfluidic technology is a recognized innovative, low-cost, and automated liquid handling system ..
  61. Mapping and modeling host-pathogen interactions in TB latency and reactivation
    Eduardo Sontag; Fiscal Year: 2013
    ..networks in the tubercle bacillus and construct mechanistic mathematical models to determine dormancy switch logic. In particular, we will test whether the network controlling the transition to dormancy results from the ..
  62. microRNAs and integrative control of cardiopoiesis
    Mark Mercola; Fiscal Year: 2013
    ..is innovative in that it merges state of the art functional screening of miRs with miR target identification and systems analysis in order to expose the logic underying the emergence of distinct cell types in the heart from stem cells.
  63. A BREATH TEST FOR LUNG CANCER
    Michael Phillips; Fiscal Year: 2009
    ..In a study of 451 subjects, a two-minute breath test for VOC biomarkers of lung cancer combined with fuzzy logic analysis of data predicted all TNM stages of disease with 84.6% sensitivity, 80.0% specificity and 0...
  64. Rural Trial of Clinic Order Entry with Decision Support
    Matthew Samore; Fiscal Year: 2006
    ..The CCOE decision support logic will encompass drug interactions, allergy contraindications, disease management of acute respiratory infections, ..
  65. EVALUATION OF A GUIDELINE-BASED DECISION SUPPORT SYSTEM
    David Lobach; Fiscal Year: 2000
    ..The guideline server is easily expandable to include new guidelines by storing guideline content and logic in a relational knowledge base...
  66. REGULATION OF THE FIRST COMPLEMENT COMPONENT BY SALIVA
    ROBERT BOACKLE; Fiscal Year: 1991
    ..The logic for studying saliva- complement interactions is easily seen when one realizes the whole saliva is composed of not ..
  67. B Cell immunomodulation in islet transplantation
    Ali Naji; Fiscal Year: 2006
    ..Notwithstanding the logic of this approach, both clinical and experimental data clearly indicate that T cell directed immunosuppression ..
  68. Understanding the Mechanism of RNA Interference (RNAi)
    Phillip Zamore; Fiscal Year: 2009
    ..Our goal is to understand the biochemical basis and biological logic of RNAi in humans, using Drosophila and mammalian cells as models...
  69. Diagnostic Logic and Adaptive Assessment for Psychiatry
    GEOFFREY OTT; Fiscal Year: 2002
    ..to extend an existing multi-tier Internet client-server system ("CliniMetricar") by integrating active diagnostic logic. CliniMetrica currently provides systematic psychiatric assessment using the World Health Organization (WHO) ..
  70. Clinical Knowledge Hub - Conceptual Integration of Rules, Data Sets, and Queries
    Gunther Schadow; Fiscal Year: 2010
    ..and complete CDS knowledge base;(ii) the published Columbia University Medical Center'Arden Syntax Medical Logic Modules (MLM), (iii) MLMs of the Child Health Improvement through Computer Automation (CHICA) system;(iv) FDA/NLM ..
  71. DECOMPOSITION OF MEMORY FAILURE IN ALZHEIMERS DISEASE
    John Gabrieli; Fiscal Year: 1999
    ..By this logic, differences in explicit memory failures between AD and GA patients may be attributed to the neocortical damage in ..
  72. Peptide Biomarker Discovery by Mass Spectrometry for Early Detection of Liver Can
    Habtom Ressom; Fiscal Year: 2009
    ..The specific aims are the following: (1) To develop fuzzy logic based methods to detect and calibrate MS peaks...
  73. Internet Support for Self-Managing Neuropathic Pain
    Jonas I Bromberg; Fiscal Year: 2010
    ..and deliver highly targeted content to individual users that address user's priorities and problems;and (2) a logic-based development platform to deploy branching logic for tailoring the flow of lesson content and assessment ..
  74. LOGIC CONTROLLED ELECTROMECHANICAL FREE KNEE ORTHOSIS
    Kenton Kaufman; Fiscal Year: 2000
    ..To accomplish this goal, plans are to: 1) perform design enhancements to the logic-controlled electromechanical free-knee orthosis which will yield a durable and reliable, totally integrated ..