Genomes and Genes
21st century history
Summary: Time period from 2001 through 2100 of the common era.
Publications274 found, 100 shown here
- Interleukin-6: from basic science to medicine--40 years in immunologyTadamitsu Kishimoto
Graduate School of Frontier Bioscience, Osaka University, Osaka 565 0871, Japan
Annu Rev Immunol 23:1-21. 2005....
- From malaria control to eradication: The WHO perspectiveKamini Mendis
Global Malaria Programme, World Health Organization, Geneva, Switzerland
Trop Med Int Health 14:802-9. 2009..The prospects of malaria eradication, therefore, rest heavily on the outcomes of research and development for new and improved tools. Malaria control and elimination are complementary objectives in the global fight against malaria...
- Key scientific issues in the health risk assessment of trichloroethyleneWeihsueh A Chiu
National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, Washington, DC, USA
Environ Health Perspect 114:1445-9. 2006....
- The challenges of changing national malaria drug policy to artemisinin-based combinations in KenyaAbdinasir A Amin
Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya
Malar J 6:72. 2007....
- Marburgvirus genomics and association with a large hemorrhagic fever outbreak in AngolaJonathan S Towner
Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop G14, Atlanta, GA 30333, USA
J Virol 80:6497-516. 2006..This is in contrast to the 1998 to 2000 marburgvirus outbreak, where evidence of several virus genetic lineages (with up to 21% divergence) and multiple virus introductions into the human population was found...
- A reflection on HIV/AIDS research after 25 yearsRobert C Gallo
Institute of Human Virology, University of Maryland Biotechnology Institute and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Retrovirology 3:72. 2006..Dr. Robert C. Gallo provides a personal reflection on the 25 year history of AIDS...
- Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolutionElodie Ghedin
The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, Maryland 20850, USA
Nature 437:1162-6. 2005..All data from this project are being deposited, without delay, in public archives...
- Issues in the pharmacokinetics of trichloroethylene and its metabolitesWeihsueh A Chiu
National Center for Environmental Assessment, U S Environmental Protection Agency, Washington, DC, USA
Environ Health Perspect 114:1450-6. 2006..It will be a challenge to develop reliable dosimetry for such cases...
- Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicityNagalakshmi Keshava
National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, Washington, DC, USA
Environ Health Perspect 114:1464-70. 2006....
- Teaching "one medicine, one health"Laura H Kahn
Program on Science and Global Security, Woodrow Wilson School of Public and International Affairs, Princeton University, Princeton, NJ, USA
Am J Med 121:169-70. 2008
- Emerging and reemerging diseases: a historical perspectiveFrank M Snowden
Department of History, Yale University, New Haven, CT 06520 8324, USA
Immunol Rev 225:9-26. 2008..These mechanisms were tested by severe acute respiratory syndrome in 2003, and a series of practical and conceptual blind spots in preparedness were revealed...
- The Genomes On Line Database (GOLD) in 2007: status of genomic and metagenomic projects and their associated metadataKonstantinos Liolios
University of Chicago, Department of Medicine, Chicago, Genome Biology Program, Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, USA
Nucleic Acids Res 36:D475-9. 2008..GOLD is available at http://www.genomesonline.org and has a mirror site at the Institute of Molecular Biology and Biotechnology, Crete, Greece at http://gold.imbb.forth.gr/..
- A clinical study of kuru patients with long incubation periods at the end of the epidemic in Papua New GuineaJohn Collinge
Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Philos Trans R Soc Lond B Biol Sci 363:3725-39. 2008..Importantly, no evidence for lymphoreticular colonization with prions, seen uniformly in vCJD, was observed in a patient with kuru at tonsil biopsy...
- Memories of John N. Brady: scientist, mentor and friendCynthia A Pise-Masison
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, Maryland 20892, USA
Retrovirology 6:48. 2009..His research also impacted the fields of eukaryotic gene regulation and tumor suppressor proteins. John is survived by his wife, Laraine, and two sons, Matt and Kevin...
- Continuity and change in the Mediterranean medical tradition: Ruta spp. (rutaceae) in Hippocratic medicine and present practicesA Pollio
Dipartimento delle Scienze Biologiche, Sezione di Biologia Vegetale, University Federico II of Naples, Via Foria 223, 80139 Naples, Italy
J Ethnopharmacol 116:469-82. 2008..The three most diffused species Ruta chalepensis L., Ruta graveolens L., and Ruta montana (L.) L., are morphologically poorly differentiated and were probably interchangeably used during Antiquity...
- Remembering Ralph Grassmann (1957-2008)Klemens Pichler
Retrovirology 5:71. 2008
- Work among the people of the Okapa area from 1996 to the presentJerome T Whitfield
MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Philos Trans R Soc Lond B Biol Sci 363:3671. 2008
- 'The children of those who died of kuru are today still alive'Tiu Pekiyeva
Awarosa Village, Papua New Guinea Institute of Medical Research, Goroka, EHP 441, Papua New Guinea
Philos Trans R Soc Lond B Biol Sci 363:3653. 2008
- Trichloroethylene cancer epidemiology: a consideration of select issuesCheryl Siegel Scott
National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, Washington, DC, USA
Environ Health Perspect 114:1471-8. 2006..5-2.0) site-specific relative risks, given exposure conditions in these studies. However, a number of challenging issues need to be considered before drawing causal conclusions about TCE exposure and cancer from these data...
- The work of the Kuru Field Unit, Kuru Research Project of the Papua New Guinea Institute of Medical Research and MRC Prion unitWandagi H Pako
Papua New Guinea Institute of Medical Research, Papua New Guinea
Philos Trans R Soc Lond B Biol Sci 363:3652. 2008
- Some tributes to research colleagues and other contributors to our knowledge about kuruMichael P Alpers
Centre for International Health, ABCRC, Health Research Campus, Shenton Park, Curtin University, Perth, Australia
Philos Trans R Soc Lond B Biol Sci 363:3614-7. 2008
- Fire as the dominant driver of central Canadian boreal forest carbon balanceBen Bond-Lamberty
Department of Forest and Wildlife Ecology, University of Wisconsin, 1630 Linden Drive, Madison, Wisconsin 53706, USA
Nature 450:89-92. 2007..Variations in the landscape carbon balance and vegetation dominance have so far been driven largely by increases in fire frequency...
- The 1918 influenza pandemic: insights for the 21st centuryDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 195:1018-28. 2007....
- Replication of human immunodeficiency virus type 1 from entry to exitAndrew M L Lever
University of Cambridge Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
Int J Hematol 84:23-30. 2006..Here, we review in a nonexhaustive manner our current knowledge of the replication of HIV-1 inside human cells from entry to exit of the virus...
- Small philanthropy and big science: the RETROVIROLOGY prize and Stephen P. GoffKuan Teh Jeang
The National Institutes of Health, Bethesda, MD, USA
Retrovirology 2:43. 2005..Stephen P. Goff wins the 2005 RETROVIROLOGY prize...
- AIDS epidemic at age 25 and control efforts in ChinaYiming Shao
National Center for AIDS STD Control and Prevention, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xuanwu District, Beijing, China
Retrovirology 3:87. 2006..Only with a scientific approach and evidence-based strategy, can China seize the opportunity to stop AIDS at an early stage...
- Overview of pertussis: focus on epidemiology, sources of infection, and long term protection after infant vaccinationKathryn M Edwards
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232 2573, USA
Pediatr Infect Dis J 24:S104-8. 2005..Some of these cases are in infants too young to have received routine pertussis vaccination, and many are in adolescents immunized previously as young children...
- Post-transplant de novo malignancies in renal transplant recipients: the past and presentH Myron Kauffman
Research Department, United Network for Organ Sharing, Richmond, VA 23219, USA
Transpl Int 19:607-20. 2006..The substantial role that de novo malignancies play in post-transplant mortality is discussed. Finally, management recommendations for recipients who develop de novo post-transplant malignancies are briefly presented...
- A vital fluid: risk, controversy and the politics of blood donation in the era of "mad cow disease"Kate O'Neill
Department of Environmental Science, Policy and Management, University of California, Berkeley
Public Underst Sci 12:359-80. 2003..The conclusion discusses how donor deferral policies may be interpreted by the public in the light of earlier discussions, and raises issues for future research...
- Key issues in the modes of action and effects of trichloroethylene metabolites for liver and kidney tumorigenesisJane C Caldwell
National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, Washington, DC, USA
Environ Health Perspect 114:1457-63. 2006....
- Alex Langmuir and CDCWarren Winkelstein
Emerg Infect Dis 12:1619; author reply 1619. 2006
- 60 years of progress--CDC and infectious diseasesTanja Popovic
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 12:1160-1. 2006
- Medicine then and now. Presidential address to The Ulster Medical Society, 12th October 2006Gary E McVeigh
Professor of Cardiovascular Therapeutics, Dept of Therapeutics and Pharmacology, Queens University Belfast, Whitla Medical Building
Ulster Med J 76:26-30. 2007
- The international response to the outbreak of SARS in 2003David L Heymann
World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland
Philos Trans R Soc Lond B Biol Sci 359:1127-9. 2004....
- Outbreak of Marburg hemorrhagic fever in Angola: a review of the history of the disease and its biological aspectsB Lee Ligon
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
Semin Pediatr Infect Dis 16:219-24. 2005..This article reviews the history of the disease caused by Marburg virus and its biological components...
- Obituary: Francis Crick (1916-2004)Alexander Rich
Nature 430:845-7. 2004
- Physiology of psychoneuroimmunology: a personal viewHugo O Besedovsky
Department of Immunophysiology, Institute of Physiology and Pathophysiology, Deutschhausstrasse 2, 35037 Marburg, Germany
Brain Behav Immun 21:34-44. 2007..We also discuss increasing evidence that brain-born cytokines play an important role in brain physiology and in the integration of the immune-neuro-endocrine network...
- From hormones to immunity: the physiology of immunologyKeith W Kelley
Laboratory of Immunophysiology, Department of Animal Sciences, University of Illinois, Urbana, IL 61801, USA
Brain Behav Immun 18:95-113. 2004..Wasting of AIDS patients is given as an important clinical example of how TNFalpha from an activated immune system reduces IGF-I sensitivity in multiple physiologic systems, including muscle, nervous and hematopoietic tissues...
- In memoriam: Francis H.C. CrickTerrence J Sejnowski
Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Neuron 43:619-21. 2004
- Traditional Korean medicine: now and the futureKang Hyun Leem
College of Korean Medicine, Semyung University, Jechon 390 711, Korea
Neurol Res 29:S3-4. 2007..It has developed unique medical theories and methods to treat diseases including neurological disorders such as stroke, epilepsy and Parkinson's disease...
- Diarrheal diseases in the history of public healthNguendo Yongsi Hénock Blaise
Observatory on Ageing and Society Center de Recherche de I Institut Universitaire de Gériatrie, Chemin Queen Mary, Montreal, Quebec, Canada
Arch Med Res 38:159-63. 2007..This literature review is an account of both the history and current risks associated with diarrheal diseases...
- Old-growth forests as global carbon sinksSebastiaan Luyssaert
Department of Biology, University of Antwerp, 2610 Wilrijk, Belgium
Nature 455:213-5. 2008..Old-growth forests accumulate carbon for centuries and contain large quantities of it. We expect, however, that much of this carbon, even soil carbon, will move back to the atmosphere if these forests are disturbed...
- The ocular surface and its symbolismJuan Murube
Ophthalmology, University of Alcala Madrid, Spain
Ocul Surf 5:6-12. 2007
- The history of anatomy in PersiaMohammadali M Shoja
Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
J Anat 210:359-78. 2007..Knowledge of anatomy for this region in the 20th century was greatly influenced by Europe and America...
- Reading our lips: the history of lipstick regulation in Western seats of powerSarah E Schaffer
Food Drug Law J 62:165-225. 2007
- Implications of biosimilars for the futurePhilip E Johnson
H Lee Moffitt Cancer Center, 12902 Magnolia Dr, Tampa, FL 33612 9497, USA
Am J Health Syst Pharm 65:S16-22. 2008....
- Male circumcision through the ages: the role of traditionNicola Zampieri
Department of Surgical Sciences, Pediatric Surgical Unit, University of Verona, Verona, Italy
Acta Paediatr 97:1305-7. 2008..In this study, we examine the evolution of tradition concerning infant male circumcision, utilizing evidence from classical medical texts as well as information from literature, legal sources and art...
- [Violence in the early modern period: current status of research]Maike Christadler
Universitat Basel, Hirschgässlein 21, CH 4051 Basel
Gesnerus 64:231-45. 2007
- The development of spinal cord anatomyJ M S Pearce
Emeritus Consultant Neurologist, Department of Neurology, Hull Royal Infirmary, Hull, UK
Eur Neurol 59:286-91. 2008..Anatomy advanced gradually to yield discoveries of the complex tracts and grey matter elements of the cord and their functions. Amongst many distinguished exponents, the works of Blasius, Huber, Vicq d'Azyr and Stilling are emphasised...
- Nutrition and fitness from the first Olympiad in 776 BC to the 21st century and the concept of positive healthArtemis P Simopoulos
The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
World Rev Nutr Diet 98:1-22. 2008
- [Regenerative medicine. New therapeutic methods in otorhinolaryngology and head and neck surgery]H Löwenheim
Klinik für Hals Nasen Ohren Heilkunde, Universitatsklinikum Tubingen, Elfriede Aulhorn Strasse 5, 72076 Tubingen, Deutschland
HNO 56:252-7. 2008
- Romancing the chiasm: vision, vocalization, and virtuosityJoel S Glaser
J Neuroophthalmol 28:131-43. 2008
- Neurophilosophy: the early years and new directionsPatricia Smith Churchland
Department of Philosophy, University of California, San Diego, La Jolla, CA 92093 0119, USA
Funct Neurol 22:185-95. 2007..Some large-scale mind-brain problems have not yet been solved, and do require significant theoretical innovation. In particular the problem of how to understand the true nature of representations remains unsolved...
- Numeric expression of aesthetics and beautyB S Atiyeh
Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon
Aesthetic Plast Surg 32:209-16; discussion 217-9. 2008....
- Global climate change, war, and population decline in recent human historyDavid D Zhang
Department of Geography, University of Hong Kong, Pokfulam Road, Hong Kong
Proc Natl Acad Sci U S A 104:19214-9. 2007..Findings of this research may lend an additional dimension to the classic concepts of Malthusianism and Darwinism...
- Impact of millennial mining activities on sediments and microfauna of the Tinto River estuary (SW Spain)F Ruiz
Departamento de Geodinámica y Paleontología, Universidad de Huelva, Avda Tres de Marzo, S N, 21071 Huelva, Spain
Mar Pollut Bull 56:1258-64. 2008....
- [History of tracheotomy]Jurek Olszewski
Klinika Otolaryngologii i Onkologii Laryngologicznej II Katedry Otolaryngologii UM w Lodzi
Otolaryngol Pol 61:349-52. 2007..Fantoni with his group. Modern methods of transdermal pharyngotomy are good complementary techniques for classical methods of pharyngotomy in both emergency and chronic cases...
- The domestication of artichoke and cardoon: from Roman times to the genomic ageGabriella Sonnante
CNR Institute of Plant Genetics, Via Amendola 165 A, 70126 Bari, Italy
Ann Bot 100:1095-100. 2007..Here, new trends in artichoke cultivation are analysed, while the consequences of these tendencies on the conservation of artichoke genetic resources are highlighted...
- "Taking the waters"--springs, wells, and spasWilliam A Frosch
Department of Psychiatry, Weill Cornell Medical College, 525 East 68th St, New York, NY 10021, USA
FASEB J 21:1948-50. 2007
- Historical eutrophication in a river-estuary complex in mid-coast MaineDörte Köster
Biology Department and Environmental Studies Program, Bowdoin College, Brunswick, Maine 04011, USA
Ecol Appl 17:765-78. 2007....
- Buddhism and breastfeedingMasashi Segawa
Department of Pediatrics, Kin i kyo Sapporo Hospital, Sapporo, Japan
Breastfeed Med 3:124-8. 2008..Breastfeeding has been a strong practice for centuries with the custom being to continue until the child is 6 or 7 years of age. The Edo period was very influential in establishing breastfeeding customs that continue today...
- Smallpox: anything to declare?Geoffrey L Smith
Department of Virology, The Wright Fleming Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, St Mary s Campus, Norfolk Place, London W2 1P6, UK
Nat Rev Immunol 2:521-7. 2002..In the words of Rep. Christopher Shay, 'Better to be scared by the improbable possibility than to be unprepared for the catastrophic reality'...
- Impact of infectious diseases on warMatthew R Smallman-Raynor
School of Geography, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
Infect Dis Clin North Am 18:341-68. 2004..The article concludes with a brief overview of infectious disease activity in high- and low-intensity conflicts of the late twentieth and early twenty-first centuries...
- A brief history of therapy for traumatic spinal cord injuryJason Lifshutz
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
Neurosurg Focus 16:E5. 2004..As in the past, the integration of basic science and clinical innovation will create the path toward progress for treatment of this disease...
- [The history of the flea in art and literature]R Roncalli Amici
American Association of Veterinary Parasitologists, USA
Parassitologia 46:15-8. 2004....
- A light-hearted look at a lion-hearted organ (or, a perspective from three standard deviations beyond the norm). Part 1 (of two parts)Matthew J Loe
Mayo Medical School, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Cardiovasc Pathol 13:282-92. 2004..Part 1 will cover the first five topics, and Part 2 will cover the last six topics. These data may be useful to those who are engaged in teaching about the cardiovascular system...
- [Physiology and pathophysiology of erectile dysfunction. A modern contrivance?]D Hauri
Urologische Klinik, Universitäts Spital Zürich
Urologe A 43:1423-9. 2004..Only in the middle of the nineteenth century was there recognition of the central role of relaxation of the trabecular muscles. It took another 100 years until we had a useful treatment option at hand...
- A light-hearted look at a lion-hearted organ (or, a perspective from three standard deviations beyond the norm) part 2 (of 2 parts)Matthew J Loe
Mayo Medical School, Mayo Clinic College of Medicine, Rochester, MN, USA
Cardiovasc Pathol 13:334-40. 2004..Part 1 (previously published) covered the first five topics, and Part 2 will cover the last six topics. These data may be useful to those who are engaged in teaching about the cardiovascular system...
- Tsunamis: a long-term threatQuirin Schiermeier
Nature 433:4. 2005
- [The most important sources of the Graeco-Arabic medicine]Richárd Nagy
Orvostort Kozl 48:21-33. 2003..Helped by this useful "database" researchers might be able to avoid difficulties of the first steps on this still, actually, largely unexplored field of the history of medicine ...
- Cardiopulmonary resuscitation developmentL A Geddes
IEEE Eng Med Biol Mag 24:110-3. 2005
- Founder mutations among the DutchMaurice P A Zeegers
Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
Eur J Hum Genet 12:591-600. 2004..These observations demonstrate the opportunity for gene discovery for other diseases and traits in the Netherlands...
- [Historical development of parental conscience]Y Knibiehler
Université d Aix en Provence, parc Mozart, 7 avenue Claude Debussy, 13100 Aix en Provence, France
Arch Pediatr 10:1021-6. 2003
- The motor system in neuroscience: a history and analysis of conceptual developmentsM R Bennett
Neurobiology Laboratory, Department of Physiology, Institute for Biomedical Research, University of Sydney, Sydney 2006, NSW, Australia
Prog Neurobiol 67:1-52. 2002..The review concludes with what we take to be an appropriate basis for rejecting the Cartesian paradigm that we hope will assist neuroscientists in understanding the integrative action of the nervous system...
- A history of psychiatric ethicsSidney Bloch
University of Melbourne, St Vincent s Hospital, 46 Nicholson Street, Fitzroy, VIC 3065, Australia
Psychiatr Clin North Am 25:509-24. 2002..42] and the Bourbons ("They learn nothing and they forget nothing") ...
- The genesis of neurosurgery and the evolution of the neurosurgical operative environment: part I-prehistory to 2003Charles Y Liu
Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Neurosurgery 52:3-19; discussion 19. 2003..To remain current, each neurosurgeon should periodically reconsider his or her personal operative environment and its functional design with reference to modernity of practice as currently defined...
- [Sacer ignis, quam pustulam vocant pastores: anthrax--cultural historical traces of a zoonosis]J Eitel
Clinica veterinaria alla Moesa, Grono
Schweiz Arch Tierheilkd 145:7-16. 2003..The crucial term is "Sacer Ignis", synonymous for several different human and animal diseases through time. This term will be analysed in terms of linguistic origin and the changes in meaning it acquired throughout the centuries...
- Mental health and psychiatry in the Middle East: historical developmentA Mohit
Division of Health Protection and Promotion, World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt
East Mediterr Health J 7:336-47. 2001..The Middle East is considered as a cultural entity and the influence of the beliefs and practices of ancient times on the collective mind of the people of the Region is discussed...
- President's address: "spacetime" and the academic and clinical missions of medical schoolsRobert M Carey
University of Virginia, P O Box 801414, UVA Health System, Charlottesville, VA 22908 1414, USA
Trans Am Clin Climatol Assoc 114:1-35. 2003
- Directions in biomedical research: a plea for ideological pluralismP Colm Malone
129 Viceroy Close, Birmingham, UK
Med Hypotheses 61:194-9. 2003..Pluralism' implies that no scientific perspective would be second-rate in a relativist framework.)..
- [Complex nasal reconstruction: past, present, and future techniques]D Martin
Service de chirurgie plastique reconstructrice et esthétique, Hopital du Tondu, Groupe Hospitalier Pellegrin, 33076 Bordeaux Cedex
Rev Stomatol Chir Maxillofac 104:149-58. 2003
- [Epidemiology of errors in health]Enrico Bollero
Policlinico Università di Roma Tor Vergata
Ig Sanita Pubbl 59:7-50. 2003
- History of chemical and biological warfare agentsL Szinicz
Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstr 11, D 80937 Munich, Germany
Toxicology 214:167-81. 2005..The following article gives a condensed overview on the history of use and development of the more prominent chemical and biological warfare agents...
- Hemodynamic profiles of heart failure patients and "elementary qualities" of pre-hippocratic medicine: a hypothesis for a linguistic and epistemological relationshipGian Franco Gensini
Med Hypotheses 66:1246-8. 2006
- [The Hippocratic Oath: how many covenants, how many oaths?]Charlotte Schubert
Universitat Leipzig, Historisches Seminar, Lehrstuhl für Alte Geschichte, Leipzig
Medizinhist J 40:247-73. 2005..The article concludes that, as early as the third century A.D., Christian influences played an equally significant role in the transmission of the Oath as pagan influences...
- Comment on Martínez-García et al. "Heavy metals in human bones in different historical epochs"Andrew Millard
Sci Total Environ 354:295-7; author reply 298-302. 2006..Lifetime heavy metal exposure cannot be deduced from diagenetically altered concentrations...
- Lithogenic, oceanic and anthropogenic sources of atmospheric Sb to a maritime blanket bog, Myrarnar, Faroe IslandsWilliam Shotyk
Institute of Environmental Geochemistry, University of Heidelberg, INF 236, D 69120, Heidelberg, Germany
J Environ Monit 7:1148-54. 2005....
- Embracing bioethics in neonatal intensive care, part I: evolving toward neonatal evidence-based ethicsIsabell B Purdy
NICU Clinical Research and HRI Follow Up, David Geffen School of Medicine, UCLA, Division of Neonatology and Developmental Biology, Los Angeles, CA 90095 1752, USA
Neonatal Netw 25:33-42. 2006..It also includes recommendations for enhancing the skills of neonatal nurses as patient advocates in NICU ethical issues, an area that is, at times, controversial and baffling to clinicians...
- A comparison of antimony and lead profiles over the past 2500 years in Flanders Moss ombrotrophic peat bog, ScotlandJoanna M Cloy
School of Geosciences, The University of Edinburgh, West Mains Road, Edinburgh, UKEH9 3JJ
J Environ Monit 7:1137-47. 2005....
- A 2,000-year record of mercury and ancient civilizations in seal hairs from King George Island, West AntarcticaLiguang Sun
Institute of Polar Environment, University of Science and Technology of China, Hefei, Anhui 230026, PR China
Sci Total Environ 368:236-47. 2006....
- Breastfeeding--was a life line in the past and still is!Yngve Hofvander
Department of Women s and Children s Health, Uppsala University, Sweden
Ups J Med Sci 111:17-25. 2006
- [Peripheral nerve repair: 30 centuries of scientific research]C Desouches
Service de Chirurgie de la Main, chirurgie plastique et réparatrice des membres, Assistance Publique, Hopitaux de Marseille, Hopital de la Conception, Marseille
Rev Neurol (Paris) 161:1045-59. 2005..Microsurgical techniques introduced in the late 1950s and widely developed for the past 20 years have improved repairs. However, functional recovery following a peripheral mixed nerve injury is still incomplete...
- [Brain, mind and symptoms]E García-Albea Ristol
Seccion de Neurologia, Universidad de Alcala, Hospital Principe de Asturias, Alcala de Henares, Madrid, Spain
Rev Neurol 42:439-43. 2006....
- Heavy metals in human bones in different historical epochsM J Martínez-García
Department of Chemical and Environmental Engineering, Technical University of Cartagena, Spain
Sci Total Environ 348:51-72. 2005..For copper, this peak is found in the Byzantine Period and for iron, in the Islamic Period. Zinc shows an increasing tendency over the periods under study and cadmium is the only metal whose trend lines shows a decreasing slope...
- Centennial review of corneal transplantationS Louise Moffatt
Department of Ophthalmology, University of Auckland, Auckland, New Zealand
Clin Experiment Ophthalmol 33:642-57. 2005....
- History and current concepts in the analysis of facial attractivenessMounir Bashour
University of Toronto, Ontario, Canada
Plast Reconstr Surg 118:741-56. 2006....
- [Biographie of Europe: Confidence basis for a successful union]D P Mertz
Versicherungsmedizin 57:147-51. 2005
- [About the concept of madness and its reflexes on mental health care]Lia Carneiro Silveira
Universidade Estadual do Ceara
Rev Lat Am Enfermagem 13:591-5. 2005..We conclude that getting to know the historical forms of the madness concept is important to be able to denaturalize our conceptions and reflect about our current practice in care for patients going through mental suffering...
- Bacillus (corynebacterium) xerosis and the ocular surfaceJuan Murube
University of Alcala Madrid, Spain
Ocul Surf 4:6-9. 2006
- [Historical background of researches in headache]Koichi Shibata
Department of Medicine, Tokyo Women s Medical University, School of Medicine, Daini Hospital
Nihon Rinsho 63:1699-704. 2005..The research evidence for special role of serotonin was revealed by modern approach and the mechanism of migraine was presented in trigeminovascular system. The development of the basic science leads to new treatments in headache clinic...
- Eyes on the prize: federal Alzheimer's research effort aims to facilitate interventionsRichard J Hodes
National Institute on Aging, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD, USA
Alzheimers Dement 4:S37-47. 2008..This article describes the progress to date and potentially promising areas of study from the vantage point of the National Institute on Aging...
- TARGETING DEFENSES OF MYCOBACTERIUM TUBERCULOSISCarl Nathan; Fiscal Year: 2004..abstract_text> ..
- Immune Enhancement and Therapy of CancerDouglas Hanahan; Fiscal Year: 2008..A remarkable group of tumor biologists and immunologists has been assembled to pursue these strategic goals with their collectively enabling and complementary expertise. ..
- South Bronx EJ Partnership and Ethical Issues in EHALVIN STRELNICK; Fiscal Year: 2006..Formal evaluation will be conducted of all specific activities, including formative, process, and outcome evaluations, and will be the responsibility of the principal investigator. ..
- BRONX SCIENCE EDUCATION PARTNERSHIPALVIN STRELNICK; Fiscal Year: 2004..Phase II will concentrate on dissemination. The partnership will train 50 teachers and 45 clinicians starting in year 01 and 40 new teachers in years 02 and 03. ..
- Specificity and Structure: The Kex 2 and Furin ProteasesRobert Fuller; Fiscal Year: 2005..2. To elucidate the biochemistry and physiology of processing of yeast cell wall proteins by Kex2p and GPI-anchored aspartyl proteases. 3. To achieve Kex2p and furin crystallization to advance determination of their structures. ..
- Dihydrolipoamide Acyltransferase:Target for ChemotherapyCarl Nathan; Fiscal Year: 2004..abstract_text> ..
- GOLGI TARGETING AND RETENTION OF YEAST KEX2 PROTEASERobert Fuller; Fiscal Year: 2009..3. To determine how cargo proteins are recruited to TGN-PVC transport vesicles and how they interact with adaptors or other components of the vesicle coat. ..
- Effects of perinatal endocrine disrupters in childrenPhilippe Grandjean; Fiscal Year: 2004..Modern statistical methods will be used to determine whether these outcome variables are associated with estrogen, thyroid, or Ah receptor abnormalities and specific contaminant exposures prenatally or postnatally. ..
- CELLULAR BASIS OF HYPERSENSITIVITY DISEASES IN HUMANSFRANK AUSTEN; Fiscal Year: 2007..abstract_text> ..
- ROLE OF NO SYNTHASE-2 IN MURINE ALZHEIMER'S DISEASECarl Nathan; Fiscal Year: 2004..abstract_text> ..
- South Bronx Environmental Justice PartnershipALVIN STRELNICK; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- MYCOBACTERIAL RESISTANCE TO REACTIVE NITROGEN/OXYGENCarl Nathan; Fiscal Year: 2003....
- Three-generation Human Study of Reproductive Effects of Marine Food ContaminantsPHILIPPE ADAM GRANDJEAN; Fiscal Year: 2010..Current evidence already suggests that these pathologies may already affect many populations, and the present proposal aims at identifying whether persistent organochlorine pollutants contribute to these abnormalities. ..
- Health Effects of Lifetime Exposure to Food ContaminantsPhilippe Grandjean; Fiscal Year: 2009..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
- MACROPHAGES, DENDRITIC CELLS AND PATHOGENSCarl Nathan; Fiscal Year: 2007..Cores provide for BSL3 wet lab and mouse work; microarray analysis of gene expression; computation and comparison of gene expression results; and high throughput screening of chemical libraries. ..
- The Effect of Statins on Skeletal Muscle FunctionPAUL DAVIS THOMPSON; Fiscal Year: 2010....
- TOTAL SYNTHESIS OF AZADIRACHTINK Nicolaou; Fiscal Year: 2008..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
- PRIMARY STRUCTURE OF PROTHROMBINKenneth Mann; Fiscal Year: 2008..The major aim of this project is to elucidate the structure/function relationships of this material with respect to factor V inactivation and to access its potential significance in the pathology of human thrombosis. ..
- Vascular Biology of Tissue FactorWolfram Ruf; Fiscal Year: 2008..These studies have, and will continue to produce original data and advanced knowledge of the TF driven thrombotic and inflammatory diseases and new routes to reduce the impact of these diseases. ..
- NALTREXONE AND CBT FOR PATIENTS WITH ALCOHOLISM AND PTSDEdna Foa; Fiscal Year: 2008..Therefore the findings from this study will be highly credible and should impact significantly on treatment recommendations for this impaired population. ..
- Young Adult Environmental and Physical Activity DynamicsBarry Popkin; Fiscal Year: 2008..No study heretofore has had large-scale groupings and in-depth environmental measures over time to examine these issues in a dynamic manner. ..
- NEURAL AND HORMONAL BASES OF VOCALIZATIONArthur Arnold; Fiscal Year: 2008..The proposed experiments will shed light on genetic and hormonal mechanisms of brain sexual differentiation, and may provide new understanding of sex differences in brain development and disease. ..
- Beta-catenin as a tumor suppressor in sarcomagenesis.Igor Matushansky; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- Blood Systems BiologyScott Diamond; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Mitochondria and Apoptosis (revised GM60554)John Reed; Fiscal Year: 2009..abstract_text> ..
- Hypocretin and Drug AddictionLuis de Lecea; Fiscal Year: 2010..This demonstration may lead to future treatments to prevent relapse. ..
- Chemically Programmed Antibodies for Cancer TherapyCarlos F Barbas; Fiscal Year: 2010..It is anticipated that the results of this work will provide a promising new approach to the treatment of cancer. ..
- Lymphocyte Survival: Implications for lymphomagenesisCraig B Thompson; Fiscal Year: 2010....
- Transcriptional Blockades of HIV-1Carlos F Barbas; Fiscal Year: 2010..The new approach we develop will be applicable to other diseases. ..
- Efficacy of 25-hydroxyvitamin D3 in colon cancer chemopreventionRajendra G Mehta; Fiscal Year: 2010..The studies will provide a rationale for using 25(OH)D3 for the prevention of colon carcinogenesis. ..
- A POLYMERIC DRUG DELIVERY SYSTEM FOR CANCER THERAPYJINDRICH H KOPECEK; Fiscal Year: 2010..The concept of double-targeted macromolecular therapeutics provides a new paradigm for the design of efficient anticancer drugs for the treatment of ovarian cancer. ..
- Experimental and Computational Studies of Exit from Mitosis in Budding YeastJohn J Tyson; Fiscal Year: 2010..g., embryonic development, tissue regeneration, wound healing, and carcinogenesis. ..
- Role of transcription in genomic stabilityPhilip Hanawalt; Fiscal Year: 2008..abstract_text> ..
- Metabolic Effects of Newer Antipsychotics in Older PtsDilip Jeste; Fiscal Year: 2009..abstract_text> ..
- Synergism Between Influenza Virus and PneumococcusJonathan McCullers; Fiscal Year: 2009....
- Brain Imaging in Major Psychoses: Functional ImagingNancy Andreasen; Fiscal Year: 2009..abstract_text> ..
- Using MEPS Data to Inform Public-Plan ConsumerismMatthew Davis; Fiscal Year: 2007..Findings will have immediate relevance for implementation of the HOA projects and other consumerism efforts. [unreadable] [unreadable] [unreadable]..
- Views and Approaches Toward Research Integrity Among IRBsRobert Klitzman; Fiscal Year: 2007..We anticipate that the data from this study will serve as a significant foundation in assisting future research and the improvement of Rl through guidelines, education and other capacity building. [unreadable] [unreadable] [unreadable]..
- Neurotoxic Interactions of Different Forms of MercuryBernard Weiss; Fiscal Year: 2007..The acquisition of these data offers a firm foundation for determining the risks to neurobehavioral development of concurrent exposures to both mercury species. ..
- RESPONSIVE POLYMER ENGINEERED PROTEIN CONJUGATESAllan Hoffman; Fiscal Year: 2001..This action should increase the efficacies of gene, antisense oligonucleotide, and cancer therapies. ..
- Oral Immunology/Microbiology Research Group Annual MtgDaniel Fine; Fiscal Year: 2003..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
- Development of a Microarray for CTL DetectionBruce Walker; Fiscal Year: 2003..Efforts to develop and apply this new technology to HIV immunology would only be possible through the developmental funds available through this grant program. ..
- CHRONIC HEPATITIS C: MOLECULAR & CELLULAR MARKERSGeoffrey Farrell; Fiscal Year: 2003..It will also allow the design of adjunctive treatments more appropriately targeted towards the key pathogenic processes that determine disease progression. ..
- GENE REGULATION DURING INTERMITTENT HYPOXIANanduri Prabhakar; Fiscal Year: 2003....
- Mapping and Cloning Prostate Cancer Predisposition LociLisa Cannon Albright; Fiscal Year: 2004..This proposal supports the University of Utah high-risk pedigree collection and analysis, and some Myriad genotyping effort towards this goal. ..
- NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILAPATRICK O FARRELL; Fiscal Year: 2003..Similar tools will be developed to dissect the signal transduction pathway that provokes adaptive changes in behavior and cell cycle progression in response to reduced oxygen. ..
- ENVIRONMENTAL/INDUSTRIAL TOXICANTS AND TESTICULAR INJURYKim Boekelheide; Fiscal Year: 2003..Together, these complimentary approaches will elucidate the key molecular mechanisms responsible for irreversible testicular injury. ..
- PATHOBIOLOGY OF CEREBRAL CAVERNOUS MALFORMATIONRichard Lifton; Fiscal Year: 2002..They have established a collection of these lesions and have begun developing cell cultures of different cell lines from lesions in order to pursue this aim. ..
- PHASE SHIFTING EFFECTS OF MELATONIN IN WINTER DEPRESSIONAlfred Lewy; Fiscal Year: 2001..The proposed study should further our understanding of light melatonin and biological rhythms in winter depression. ..
- CYP1A1 GENE AND ENVIRONMENTAL TOXICITYDaniel Nebert; Fiscal Year: 2005..abstract_text> ..
- Platelet interactions with vessel wall componentsZAVERIO RUGGERI; Fiscal Year: 2005..These findings will provide a better definition and characterization of several potential targets for antithrombotic intervention that may yield new treatments for patients at risk of cardiovascular and cerebrovascular events. ..
- BUILDING THE TOOTH: BRIDGING BIOLOGY IN MATERIAL SCIENCESMalcolm Snead; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Isotopically Labeled Nucleotides for Biomolecular NMRJames Williamson; Fiscal Year: 2007..In order to make these reagents widely available to the structural biology community, we propose to optimize and scale up production of these reagents for commercial distribution. ..
- NEUROPEPTIDE CORTISTATIN AND SLEEPLuis de Lecea; Fiscal Year: 2006..abstract_text> ..
- Lymphocyte Activation and SignalingGary Koretzky; Fiscal Year: 2006..abstract_text> ..
- Microglia and the Neuropathogenesis of HIV DiseaseWarner Greene; Fiscal Year: 2006..This work should both define the utility of this new experimental system for studying neuropathogenesis and provide new information about the pathologic events that may contribute to impairment of neurologic function in HIV disease. ..
- COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECTKeith Rasmussen; Fiscal Year: 2005..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
- Development of a post-exposure vaccine for smallpoxBertram Jacobs; Fiscal Year: 2005..This work will provide the pre-clinical data for filing an IND fora new post-exposure prophylactic drug for exposure to smallpox. ..
- Alcoholism: Sleep and Cytokines in African AmericansMichael Irwin; Fiscal Year: 2005..g., cytokine antagonists) for sleep disturbance in alcoholism. ..
- Glucose Regulation of Pancreatic Islet Gene ExperessionRODERICK PAUL ROBERTSON; Fiscal Year: 2010..We will study whether increasing antioxidant protection protects these cells and prevents deterioration of glucose control in diabetes. ..
- Experimental Radiotherapy and Chemotherapy With a Potent New Hypoxic CytotoxinJOHN MARTIN BROWN; Fiscal Year: 2010....
- Varian 4 Tesla MRI/MRS for Neuro-degenerative DiseasesMichael Weiner; Fiscal Year: 2002..These expected results emphasize the practical outcome and significance of this research. ..
- NEUROCOMPUTATIONAL ANALYSIS OF LEARNINGTHOMAS CAREW; Fiscal Year: 2001....
- Control of Somatic Stem Cell Proliferation by Oct4Christopher Lengner; Fiscal Year: 2008..This proposal will delineate molecular mechanisms that can potentially be manipulated to enhance regenerative medicine. [unreadable] [unreadable]..
- Human Bladder Urothelial Cell Structure and Function in Bladder HypersensationToby C Chai; Fiscal Year: 2010..By accomplishing these aims, we hope to develop an understanding of the pathogenesis of hypersensory bladder conditions which ultimately can lead to targeted treatment options. ..
- PHTHALATE-INDUCED MURINE TESTICULAR DYSGENESIS AND P53Kim Boekelheide; Fiscal Year: 2007..unreadable] [unreadable]..
- ORGANIZATION OF THE VISUAL SYSTEMDavid Hubel; Fiscal Year: 2004..We will study their enzyme histochemistry, development, and differences in different species including normal and blind or amblyopic humans. ..
- EVALUATION OF NOVEL COCAINE MEDICATIONSBertha Madras; Fiscal Year: 2005..abstract_text> ..