Genomes and Genes
20th century history
Summary: Time period from 1901 through 2000 of the common era.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications336 found, 100 shown here
- The first laparoscopic cholecystectomyW Reynolds
Northeast Alabama Regional Medical Center, Anniston, USA
JSLS 5:89-94. 2001..The other purpose is to give Mühe the recognition he deserves for being the developer of the laparoscopic cholecystectomy procedure...
- Rurality and pandemic influenza: geographic heterogeneity in the risks of infection and death in Kanagawa, Japan (1918-1919)Hiroshi Nishiura
Theoretical Epidemiology, University of Utrecht, Yalelaan 7, 3584 CL, Utrecht, The Netherlands
N Z Med J 121:18-27. 2008..To characterise the impact of rurality on the spread of pandemic influenza by exploring both the numbers of cases and deaths in Kanagawa Prefecture, Japan, from October 1918 to April 1919 inclusive...
- A clinical study of kuru patients with long incubation periods at the end of the epidemic in Papua New GuineaJohn Collinge
Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Philos Trans R Soc Lond B Biol Sci 363:3725-39. 2008..Importantly, no evidence for lymphoreticular colonization with prions, seen uniformly in vCJD, was observed in a patient with kuru at tonsil biopsy...
- Mortuary rites of the South Fore and kuruJerome T Whitfield
MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Philos Trans R Soc Lond B Biol Sci 363:3721-4. 2008..The exclusion of alternative routes of transmission is of importance owing to the dietary exposure of the UK and other populations to bovine spongiform encephalopathy prions...
- The late 1970s: a lull in the action on kuruPhillip I Tarr
Edward Mallinckrodt Department of Pediatrics, Division of Gastroenterology, Washington University School of Medicine, St Louis, MO 63110, USA
Philos Trans R Soc Lond B Biol Sci 363:3668-70. 2008
- 1918 Influenza: the mother of all pandemicsJeffery K Taubenberger
Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
Emerg Infect Dis 12:15-22. 2006..But, the viral genome alone is unlikely to provide answers to some critical questions. Understanding the 1918 pandemic and its implications for future pandemics requires careful experimentation and in-depth historical analysis...
- Epidemiological evidence of an early wave of the 1918 influenza pandemic in New York CityDonald R Olson
Department of Epidemiology and Center for Public Health Preparedness, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 102:11059-63. 2005..The timing, magnitude, and age distribution of this mortality shift provide strong evidence that an early wave of the pandemic virus was present in New York City during February-April 1918...
- Updating the accounts: global mortality of the 1918-1920 "Spanish" influenza pandemicNiall P A S Johnson
Bull Hist Med 76:105-15. 2002..7-39.3 million. This paper suggests that it was of the order of 50 million. However, it must be acknowledged that even this vast figure may be substantially lower than the real toll, perhaps as much as 100 percent understated...
- Influenza pandemics of the 20th centuryEdwin D Kilbourne
New York Medical College, Valhalla, New York, USA
Emerg Infect Dis 12:9-14. 2006..Evidence suggests that true pandemics with changes in hemagglutinin subtypes arise from genetic reassortment with animal influenza A viruses...
- World War I may have allowed the emergence of "Spanish" influenzaJ S Oxford
Department of Medical Microbiology and Retroscreen Virology, St Bartholomew s and The Royal London, Queen Mary, School of Medicine and Dentistry, University of London, London, UK
Lancet Infect Dis 2:111-4. 2002..We suggest that the pandemic had its origins on the Western Front, and that World War I was a contributor...
- Integrated pest management (IPM): definition, historical development and implementation, and the other IPMLester E Ehler
Department of Entomology, University of California, One Shields Avenue, Davis, CA 95616, USA
Pest Manag Sci 62:787-9. 2006
- Origin and evolution of the 1918 "Spanish" influenza virus hemagglutinin geneA H Reid
Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington, DC 20306 6000, USA
Proc Natl Acad Sci U S A 96:1651-6. 1999..Phylogenetic analyses suggest that the 1918 virus HA gene, although more closely related to avian strains than any other mammalian sequence, is mammalian and may have been adapting in humans before 1918...
- Control of Japanese encephalitis--within our grasp?Tom Solomon
United Kingdom Medical Research Council, United Kingdom
N Engl J Med 355:869-71. 2006
- Interleukin-6: from basic science to medicine--40 years in immunologyTadamitsu Kishimoto
Graduate School of Frontier Bioscience, Osaka University, Osaka 565 0871, Japan
Annu Rev Immunol 23:1-21. 2005....
- From malaria control to eradication: The WHO perspectiveKamini Mendis
Global Malaria Programme, World Health Organization, Geneva, Switzerland
Trop Med Int Health 14:802-9. 2009..The prospects of malaria eradication, therefore, rest heavily on the outcomes of research and development for new and improved tools. Malaria control and elimination are complementary objectives in the global fight against malaria...
- The 1918-1919 influenza pandemic in England and Wales: spatial patterns in transmissibility and mortality impactGerardo Chowell
School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287, USA
Proc Biol Sci 275:501-9. 2008..Further studies of the geographical mortality patterns associated with the 1918-1919 influenza pandemic may be useful for pandemic planning...
- Breast cancer risk after caloric restriction during the 1944-1945 Dutch famineSjoerd G Elias
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
J Natl Cancer Inst 96:539-46. 2004..We examined whether caloric restriction imposed as a consequence of the 1944-1945 Dutch famine reduced the risk of breast cancer in women participating in a Dutch breast cancer screening program...
- The 1918 influenza A epidemic in the city of São Paulo, BrazilEduardo Massad
School of Medicine, University of Sao Paulo, Rua Teodoro Sampaio 115, CEP 05405 000, SP, Brazil
Med Hypotheses 68:442-5. 2007....
- Epidemiologic characterization of the 1918 influenza pandemic summer wave in Copenhagen: implications for pandemic control strategiesViggo Andreasen
Department of Sciences, Roskilde University, Roskilde, Denmark
J Infect Dis 197:270-8. 2008..The 1918-1919 A/H1N1 influenza pandemic killed approximately 50 million people worldwide. Historical records suggest that an early pandemic wave struck Europe during the summer of 1918...
- Gordon Holmes Lecture: Gordon Holmes and the neurological heritageIan McDonald
Institute of Neurology Queen Square, University College London, UK
Brain 130:288-98. 2007....
- 1917 avian influenza virus sequences suggest that the 1918 pandemic virus did not acquire its hemagglutinin directly from birdsThomas G Fanning
Division of Molecular Pathology, Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Rockville, Maryland 20850 3125, USA
J Virol 76:7860-2. 2002....
- Dating the emergence of pandemic influenza virusesGavin J D Smith
Department of Microbiology, State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Proc Natl Acad Sci U S A 106:11709-12. 2009....
- The challenges of changing national malaria drug policy to artemisinin-based combinations in KenyaAbdinasir A Amin
Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya
Malar J 6:72. 2007....
- Transmissibility of 1918 pandemic influenzaChristina E Mills
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, Massachusetts 02115, USA
Nature 432:904-6. 2004..But because influenza is frequently transmitted before a specific diagnosis is possible and there is a dearth of global antiviral and vaccine stores, aggressive transmission reducing measures will probably be required...
- Alzheimer 100--highlights in the history of Alzheimer researchK A Jellinger
Institute of Clinical Neurobiology, Vienna, Austria
J Neural Transm (Vienna) 113:1603-23. 2006....
- A century of Alzheimer's diseaseMichel Goedert
Laboratory of Molecular Biology, Medical Research Council, Cambridge CB2 2QH, UK
Science 314:777-81. 2006..Genetic studies have shown that dysfunction of amyloid-beta or tau is sufficient to cause dementia. The ongoing molecular dissection of the neurodegenerative pathways is expected to lead to a true understanding of disease pathogenesis...
- Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemicRafi Ahmed
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Nat Immunol 8:1188-93. 2007....
- A reflection on HIV/AIDS research after 25 yearsRobert C Gallo
Institute of Human Virology, University of Maryland Biotechnology Institute and Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Retrovirology 3:72. 2006..Dr. Robert C. Gallo provides a personal reflection on the 25 year history of AIDS...
- Climatic suitability for malaria transmission in Africa, 1911-1995Jennifer Small
Department of Geography, University of Maryland, College Park, MD 20742 8225, USA
Proc Natl Acad Sci U S A 100:15341-5. 2003..This analysis highlights the need to examine the relationship between climate and malaria more closely and to fully consider nonclimatic factors as drivers of increased malaria transmission across the continent...
- Friedrich Feyrter: a precise intellect in a diffuse systemManish C Champaneria
Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
Neuroendocrinology 83:394-404. 2006..We describe the life and times of this gifted scientist, teacher, and pathologist, often referred to as the 'Father of Neuroendocrinology'...
- SSR allelic diversity changes in 480 European bread wheat varieties released from 1840 to 2000V Roussel
Amélioration et Santé des Plantes UMR 1095, INRA, 234 avenue du Brezet, 63039, Clermont Ferrand, Cedex 2, France
Theor Appl Genet 111:162-70. 2005....
- Rita Levi-Montalcini: the discovery of nerve growth factor and modern neurobiologyLuigi Aloe
Institute of Neurobiology and Molecular Medicine, Neurobiology Section, CNR, Viale Marx 15, 00137 Rome, Italy
Trends Cell Biol 14:395-9. 2004..Thus, Levi-Montalcini's work on NGF represents, as acknowledged by the Nobel Prize Assembly in its press release of 13 October 1986, "a fascinating example of how a skilled observer can create a concept out of apparent chaos"...
- Allelic reduction and genetic shift in the Canadian hard red spring wheat germplasm released from 1845 to 2004Yong Bi Fu
Plant Gene Resources of Canada, Saskatoon Research Centre, Agriculture and Agri Food Canada, 107 Science Place, Saskatoon, SK, S7N 0X2, Canada
Theor Appl Genet 110:1505-16. 2005..Consequently, more effort needs to be made to broaden the wheat breeding base and conserve wheat germplasm...
- Doctors and tortureRobert Jay Lifton
Department of Psychiatry, Harvard Medical School, Boston, USA
N Engl J Med 351:415-6. 2004
- Malaria control, the cold war, and the postwar reorganization of international assistanceS Litsios
Control of Tropical Diseases program, World Health Organization, Geneva
Med Anthropol 17:255-78. 1997..Whereas this transition is generally portrayed strictly in terms of the success of DDT, I document how various factors, the Cold War in particular, contributed to the "inevitability" of eradication...
- Siegfried Oberndorfer: origins and perspectives of carcinoid tumorsIrvin M Modlin
Gastric Pathobiology Research Group, Department of Surgery, Yale University School of Medinice, New Haven, CT 06520 8062, USA
Hum Pathol 35:1440-51. 2004..It also serves to memorialize the extraordinary accomplishments of Oberndorfer, whose vision exceeded his times...
- Estimation of potential global pandemic influenza mortality on the basis of vital registry data from the 1918-20 pandemic: a quantitative analysisChristopher J L Murray
Harvard Initiative for Global Health, Harvard University, Cambridge, MA 02138, USA
Lancet 368:2211-8. 2006..Our aim was to use high-quality vital registration data gathered during the 1918-20 pandemic to estimate global mortality should such a pandemic occur today...
- The effect of public health measures on the 1918 influenza pandemic in U.S. citiesMartin C J Bootsma
Mathematical Institute, Faculty of Sciences, Utrecht University, Budapestlaan 6, 3508 TA Utrecht, The Netherlands
Proc Natl Acad Sci U S A 104:7588-93. 2007..Our analysis also suggests that individuals reactively reduced their contact rates in response to high levels of mortality during the pandemic...
- Discovery of adult T-cell leukemiaKiyoshi Takatsuki
Department of Internal Medicine II, Kumamoto University School of Medicine, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Retrovirology 2:16. 2005..Moreover, it was noted that an immunodeficiency state may be induced by HTLV-1 infection. In Japan, HTLV-1 carriers have been estimated to be 1.2 million, and more than 700 cases of ATL have been diagnosed each year...
- Islet transplantation as a treatment for diabetes - a work in progressR Paul Robertson
Pacific Northwest Research Institute and the Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle 98122, USA
N Engl J Med 350:694-705. 2004
- Characterization of the reconstructed 1918 Spanish influenza pandemic virusTerrence M Tumpey
Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases DVRD, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
Science 310:77-80. 2005..Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemic virus...
- The discovery of the first human retrovirus: HTLV-1 and HTLV-2Robert C Gallo
Institute of Human Virology University of Maryland Biotechnology Institute 701 E, Pratt Street Baltimore, MD 21202, USA
Retrovirology 2:17. 2005..These efforts finally yielded success following the discovery of IL-2 and its use to culture adult T cell lymphoma/leukemia cells...
- Vitamin a deficiency and clinical disease: an historical overviewAlfred Sommer
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
J Nutr 138:1835-9. 2008....
- Still protected against smallpox? Estimation of the duration of vaccine-induced immunity against smallpoxHiroshi Nishiura
Department of Medical Biometry, University of Tubingen, Westbahnhofstrasse 55, Tübingen D 72070, Germany
Epidemiology 17:576-81. 2006..It has previously been suggested that at least partial protection against severe and fatal smallpox may persist throughout life...
- Post-transplant de novo malignancies in renal transplant recipients: the past and presentH Myron Kauffman
Research Department, United Network for Organ Sharing, Richmond, VA 23219, USA
Transpl Int 19:607-20. 2006..The substantial role that de novo malignancies play in post-transplant mortality is discussed. Finally, management recommendations for recipients who develop de novo post-transplant malignancies are briefly presented...
- Cross-protection between successive waves of the 1918-1919 influenza pandemic: epidemiological evidence from US Army camps and from BritainJohn M Barry
Center for Bioenvironmental Research, Tulane Universities, New Orleans, Louisiana 70112, USA
J Infect Dis 198:1427-34. 2008..In this article, we examine the strength of cross-protection between successive waves of the 1918-1919 pandemic, which has remained a long-standing issue of debate...
- Some tributes to research colleagues and other contributors to our knowledge about kuruMichael P Alpers
Centre for International Health, ABCRC, Health Research Campus, Shenton Park, Curtin University, Perth, Australia
Philos Trans R Soc Lond B Biol Sci 363:3614-7. 2008
- Family life at Okapa as a 'missus bilong dokta bilong kuru'Coralie Mathews
Philos Trans R Soc Lond B Biol Sci 363:3650-1. 2008
- Richard Hornabrook's first impressions of kuru and OkapaAnnette Beasley
Philos Trans R Soc Lond B Biol Sci 363:3626-7. 2008
- The expanded Laboratory of Collaborative and Field ResearchJudith Farquhar
Department of Anthropology, University of Chicago, Chicago, IL 60637, USA
Philos Trans R Soc Lond B Biol Sci 363:3634-5. 2008
- Early images of kuru and the people of OkapaD Carleton Gajdusek
Institut Neurologique Alfred Fessard, Centre National de la Recherche Scientifique, Batiment 33, Avenue de la Terrasse, 91198 Gif sur Yvette, France
Philos Trans R Soc Lond B Biol Sci 363:3636-43. 2008
- 'We had to climb mountains and cross fast-flowing rivers'Taka Gomea
Port Moresby, Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
Philos Trans R Soc Lond B Biol Sci 363:3643. 2008
- Personal reflections on the neuropathology of kuruByron A Kakulas
Australian Neuromuscular Research Institute, University of Western Australia, Crawley, WA 6009, Australia
Philos Trans R Soc Lond B Biol Sci 363:3645-6. 2008
- 'The children of those who died of kuru are today still alive'Tiu Pekiyeva
Awarosa Village, Papua New Guinea Institute of Medical Research, Goroka, EHP 441, Papua New Guinea
Philos Trans R Soc Lond B Biol Sci 363:3653. 2008
- Memories of kuru while at Okapa, Papua New Guinea in 1957Lucy M Hamilton Reid
Philos Trans R Soc Lond B Biol Sci 363:3657-9. 2008
- Reminiscences about kuru and the people of OkapaAdolf Saweri
Division of Medicine, School of Medicine and Health Sciences, University of Papua New Guinea, Boroko, Papua New Guinea
Philos Trans R Soc Lond B Biol Sci 363:3660. 2008
- Asbestos and ship-building: fatal consequencesJohn Hedley-Whyte
Harvard University, 1400 VFW Parkway, Boston, MA 02132 4927, USA
Ulster Med J 77:191-200. 2008..Boston and Belfast institutions made seminal discoveries about asbestos use and its sequelae...
- Memories of John N. Brady: scientist, mentor and friendCynthia A Pise-Masison
Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, Maryland 20892, USA
Retrovirology 6:48. 2009..His research also impacted the fields of eukaryotic gene regulation and tumor suppressor proteins. John is survived by his wife, Laraine, and two sons, Matt and Kevin...
- Integrating historical, clinical and molecular genetic data in order to explain the origin and virulence of the 1918 Spanish influenza virusJ K Taubenberger
Department of Cellular Pathology and Genetics, Armed Forces Institute of Pathology, Room 1057D, Building 101, 1413 Research Boulevard, Rockville, MD 20850 3125, USA
Philos Trans R Soc Lond B Biol Sci 356:1829-39. 2001..This information should help to elucidate how pandemic influenza strains emerge and what genetic features contribute to their virulence...
- Applications and societal benefits of plasticsAnthony L Andrady
Research Triangle Institute, Durham, NC 27709, USA
Philos Trans R Soc Lond B Biol Sci 364:1977-84. 2009..Concerns relating to littering and trends in recycling of plastics are also described. Finally, we give predictions for some of the potential applications of plastic over the next 20 years...
- Lobar pneumonia treated by Musgrave Park physiciansJohn Hedley-Whyte
David S Sheridan Professor of Anaesthesia and Respiratory Therapy, Harvard University 1400 VFW Parkway, Boston, MA 02132 4927, USA
Ulster Med J 78:119-28. 2009..The treatment option chosen by the Musgrave Park physicians in 1941, and the non-availability of penicillin led to sequelae affecting the post-Belfast careers of both patient and physicians...
- Understanding influenza transmission, immunity and pandemic threatsJohn D Mathews
Melbourne School of Population Health, The University of Melbourne, Melbourne, Australia
Influenza Other Respir Viruses 3:143-9. 2009..Nevertheless, partial protection, even of short duration, induced by prior seasonal influenza or vaccination against it, could provide important protection in the early stages of a new pandemic...
- Review. Understanding kuru: the contribution of anthropology and medicineShirley Lindenbaum
Graduate School and University Center, City University of New York, New York, NY 10016 4309, USA
Philos Trans R Soc Lond B Biol Sci 363:3715-20. 2008....
- The 1918 influenza pandemic: insights for the 21st centuryDavid M Morens
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Infect Dis 195:1018-28. 2007....
- ICD coding changes and discontinuities in trends in cause-specific mortality in six European countries, 1950-99Fanny Janssen
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 7138, 3000 DR Rotterdam, The Netherlands
Bull World Health Organ 82:904-13. 2004..To evaluate how often coding changes between and within revisions of the International Classification of Diseases (ICD) complicate the description of long-term trends in cause-specific mortality...
- Review. The epidemiology of kuru: monitoring the epidemic from its peak to its endMichael P Alpers
Centre for International Health, ABCRC, Shenton Park Campus, Curtin University, Perth, WA 6845, Australia
Philos Trans R Soc Lond B Biol Sci 363:3707-13. 2008..Currently, the epidemiological surveillance is being maintained and further studies on human genetics and the past mortuary practices are being conducted in the kuru-affected region and in communities beyond it...
- Kuru memories from 1957Roy F R Scragg
Philos Trans R Soc Lond B Biol Sci 363:3661-3. 2008
- The adelaide kuru team in 1957-1959Donald A Simpson
Philos Trans R Soc Lond B Biol Sci 363:3665. 2008
- My kuru adventureWerner H Stöcklin
Philos Trans R Soc Lond B Biol Sci 363:3666-7. 2008
- Work among the people of the Okapa area from 1996 to the presentJerome T Whitfield
MRC Prion Unit and Department of Neurodegenerative Disease, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Philos Trans R Soc Lond B Biol Sci 363:3671. 2008
- Review. Lessons of kuru research: background to recent studies with some personal reflectionsJohn Collinge
Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Philos Trans R Soc Lond B Biol Sci 363:3689-96. 2008..Although now essentially over, the kuru epidemic continues to provide important lessons...
- Kuru: memories of the NIH yearsDavid M Asher
Division of Emerging and Transfusion Transmitted Diseases, Laboratory of Bacterial, Parasitic and Unconventional Agents, United States Food and Drug Administration, Rockville, MD 20852 1448, USA
Philos Trans R Soc Lond B Biol Sci 363:3618-25. 2008
- Time variations in the transmissibility of pandemic influenza in Prussia, Germany, from 1918-19Hiroshi Nishiura
Department of Medical Biometry, University of Tubingen, Tubingen, Germany
Theor Biol Med Model 4:20. 2007....
- Some recollections about kuru in a patient at Rabaul in 1978, and subsequent experiences with prion diseasesEuan M Scrimgeour
Infectious and Tropical Diseases, 51 Woodroyd Street, Mount Lawley, WA 6050, Australia
Philos Trans R Soc Lond B Biol Sci 363:3663-4. 2008
- Kuru fieldwork in 1981 ... and beyondRobert Klitzman
Columbia University, 722 West 168th Street, New York, NY 10032, USA
Philos Trans R Soc Lond B Biol Sci 363:3646-7. 2008
- Review. Kuru and its contribution to medicineD Carleton Gajdusek
Institut Neurologique Alfred Fessard, Centre National de la Recherche Scientifique, Gif sur Yvette, France
Philos Trans R Soc Lond B Biol Sci 363:3697-700. 2008..Kuru in its location in Papua New Guinea has also led to an understanding of the cultural achievements of the Palaeo-Melanesians, with deep roots in human history...
- Alzheimer's discoveryRalf Dahm
Medical University of Vienna, Center for Brain Research, Spitalgasse 4, A 1090 Vienna, Austria
Curr Biol 16:R906-10. 2006
- Rediscovery of the case described by Alois Alzheimer in 1911: historical, histological and molecular genetic analysisM B Graeber
Max Planck Institute of Psychiatry, Department of Neuromorphology, Martinsried, Germany
Neurogenetics 1:73-80. 1997..This case is of historical importance as it may have convinced Kraepelin to name the disease after his co-worker, Alois Alzheimer...
- We see what we are trained to see, or must we? Some personal lessons from a brush with kuru researchCyril C Curtain
School of Pathology, University of Melbourne, Victoria 3010, Australia
Philos Trans R Soc Lond B Biol Sci 363:3633-4. 2008
- Epidemic jaundice: Harvard's 5th General Hospital at Musgrave Park in World War IIJohn Hedley-Whyte
Anaesthesia and Respiratory Therapy, Harvard University, Boston, MA 02132 4927, USA
Ulster Med J 74:122-5. 2005
- Family and population studies by the Adelaide Kuru Team, 1957-1965J H Bennett
University of Adelaide, Adelaide, SA 5000, Australia
Philos Trans R Soc Lond B Biol Sci 363:3629. 2008
- Early perceptions of an epidemicWarwick H Anderson
Department of History and Centre for Values, Ethics and the Law in Medicine, SOPHI, University of Sydney, A14 Quadrangle, NSW 2006, Australia
Philos Trans R Soc Lond B Biol Sci 363:3675-8. 2008..Fore attributed kuru to sorcery, anthropologists speculated on psychosomatic causes and medical officers began to wonder if it was a mysterious encephalitis...
- My 'brush' with kuru researchGabriele M Zu Rhein
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53706, USA
Philos Trans R Soc Lond B Biol Sci 363:3672-3. 2008
- Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemicsSimon Mead
Medical Research Council Prion Unit, and Department of Neurodegenerative Disease, Institute of Neurology, University College, Queen Square, London WC1N 3BG, UK
Science 300:640-3. 2003..Worldwide PRNP haplotype diversity and coding allele frequencies suggest that strong balancing selection at this locus occurred during the evolution of modern humans...
- Battling blood loss in neurosurgery: Harvey Cushing's embrace of electrosurgeryJennifer R Voorhees
Department of Neurological Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
J Neurosurg 102:745-52. 2005..Nonetheless, he did know that by greatly reducing blood loss, electrosurgery allowed him to operate in patients whose tumors had been previously deemed inoperable and on the entire spectrum of neurosurgical patients more safely...
- The age pattern of mortality in the 1918-19 influenza pandemic: an attempted explanation based on data for England and WalesChristopher Langford
Department of Social Policy, London School of Economics and Political Science, Aldwych, London WC2A 2AE
Med Hist 46:1-20. 2002
- Cytokines: past, present, and futureJ J Oppenheim
Division of Basic Sciences, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
Int J Hematol 74:3-8. 2001..The explosion in cytokine information over the past 40 years has been enormous and full of surprises. If past be prologue, with the advent of genomics and proteomics the future should witness even greater progress...
- No man alone: the rediscovery of Alois Alzheimer's original casesM B Graeber
Department of Neuromorphology, Max Planck Institute of Neurobiology, Martinsried, Germany
Brain Pathol 9:237-40. 1999..The present article summarizes the unusual history of this rediscovery and at the same time illustrates the great value of international exchange in science...
- Erich Mühe and the rejection of laparoscopic cholecystectomy (1985): a surgeon ahead of his timeG S Litynski
Institut fur Geschichte der Medizin, Johann Wolfgang Goethe Universitat, Frankfurt Main, Germany
JSLS 2:341-6. 1998..His concept, however, was ignored. In the middle of the 1980s, the surgical community was still not prepared for the era of "minimally invasive therapy." Erich Mühe was a surgeon ahead of his time...
- Reminiscences of an aspiring graduate student in the 1970s who worked on kuru-related projects with Dr GajdusekRichard Benfante
Philos Trans R Soc Lond B Biol Sci 363:3628. 2008
- Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virusClaudia Pappas
Influenza Division, Mailstop G 16, National Center for Immunization and Respiratory Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 105:3064-9. 2008..These results highlight the importance of the 1918 HA, NA, and PB1 genes for optimal virus replication and virulence of this pandemic strain...
- Characterization of the 1918 influenza virus polymerase genesJeffery K Taubenberger
Department of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, Maryland 20850, USA
Nature 437:889-93. 2005..The sequence changes identified here may be important in the adaptation of influenza viruses to humans...
- Kuru likened to scrapie: the story rememberedWilliam J Hadlow
Philos Trans R Soc Lond B Biol Sci 363:3644. 2008
- Why I joined the research laboratory of Prof. D. Carleton Gajdusek in 1968Françoise Cathala
Philos Trans R Soc Lond B Biol Sci 363:3631-2. 2008
- First impressions of the ForeShirley Lindenbaum
Graduate School and University Center, City University of New York, New York, NY 10016 4309, USA
Philos Trans R Soc Lond B Biol Sci 363:3648-9. 2008
- Dynamics of positional warfare malaria: Finland and Korea comparedLena Hulden
Department of Forest Ecology, Faculty of Agriculture and Forestry, University of Helsinki, Finland
Malar J 7:171. 2008..A revised explanation is presented based on recent studies of Finnish malaria...
- The neo-Kraepelinian revolution in psychiatric diagnosisW M Compton
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
Eur Arch Psychiatry Clin Neurosci 245:196-201. 1995..Discussion of the implications of this neo-Kraepelinian revolution in psychiatric diagnosis is included...
- Ongoing controversy over Romanov remainsMichael Hofreiter
Science 306:407-10. 2004
- Alois Alzheimer: his life and timesMichel Goedert
Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
Brain Pathol 17:57-62. 2007..His name will always be linked with the form of dementia that he described 100 years ago. Here we mark this anniversary by discussing Alzheimer's contributions to dementia research in the context of his life and times...
- Reappraisal of the historic 1959 cat experiment in Minamata by the Chisso FactoryK Eto
National Institute for Minamata Disease, Japan
Tohoku J Exp Med 194:197-203. 2001..Characteristic lesions of methylmercury poisoning were observed in the central nervous system, and the mercury levels in the cerebrum, cerebellum, liver and kidney were found to be markedly elevated in this animal...
- On being a pathologist: how does one plan a career, or does one?E Tessa Hedley-Whyte
C S Kubik Laboratory for Neuropathology, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Hum Pathol 39:1269-74. 2008
- Telerobotic Minimally Invasive ASD RepairJeremy Cannon; Fiscal Year: 2002..The initial experiments will be done with an open chest model and subsequently a port access procedure will be developed. ..
- South Bronx EJ Partnership and Ethical Issues in EHALVIN STRELNICK; Fiscal Year: 2006..Formal evaluation will be conducted of all specific activities, including formative, process, and outcome evaluations, and will be the responsibility of the principal investigator. ..
- CONFERENCE ON THE HISTORICAL CONTEXT OF OPIATE USEJOEL JUTKOWITZ; Fiscal Year: 1980..conference bringing together scholars conducting research on drugs with specialists in 19th and 20th century history. The intent of the Conference is to provide a foundation for the development of interpretative models of ..
- Anti-Selectin Blocker for Liver Ischemic InjuryLUIS TOLEDO PEREYRA; Fiscal Year: 2006..Treatment with TCB-1269 will enhance the quality of life of millions of patients suffering from the large number of maladies associated with ischemia/reperfusion ischemic maladies. [unreadable] [unreadable]..
- Raloxifene in Women with AD: Randomized Controlled TrialVICTOR HENDERSON; Fiscal Year: 2007..It is anticipated that findings from this pilot study will provide useful guidance to plan and conduct future studies of raloxifene in women with mild to moderate symptoms of dementia due to AD. ..
- ADENOSINE AND TRAUMATIC BRAIN INJURYPatrick Kochanek; Fiscal Year: 2007..These studies explore the most promising adenosine-based therapy for TBI-A2a receptor antagonists. Our bench to bedside track record ensures translation to the clinic. [unreadable] [unreadable]..
- BRONX SCIENCE EDUCATION PARTNERSHIPALVIN STRELNICK; Fiscal Year: 2004..Phase II will concentrate on dissemination. The partnership will train 50 teachers and 45 clinicians starting in year 01 and 40 new teachers in years 02 and 03. ..
- Views and Approaches Toward Research Integrity Among IRBsRobert Klitzman; Fiscal Year: 2007..We anticipate that the data from this study will serve as a significant foundation in assisting future research and the improvement of Rl through guidelines, education and other capacity building. [unreadable] [unreadable] [unreadable]..
- South Bronx Environmental Justice PartnershipALVIN STRELNICK; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Views of Privacy of Genetic InformationRobert Klitzman; Fiscal Year: 2005..The findings of this study can enhance further policy, professional and public education, and future research in this area. ..
- The Effect of Statins on Skeletal Muscle FunctionPAUL DAVIS THOMPSON; Fiscal Year: 2010....
- NMR STUDIES OF THE MECHANISMS OF ACTION OF TRP REPRESSOROleg Jardetzky; Fiscal Year: 2002..Correlation of the findings should allow an understanding of the signaling code and the design of the regulatory apparatus. ..
- A POLYMERIC DRUG DELIVERY SYSTEM FOR CANCER THERAPYJINDRICH H KOPECEK; Fiscal Year: 2010..The concept of double-targeted macromolecular therapeutics provides a new paradigm for the design of efficient anticancer drugs for the treatment of ovarian cancer. ..
- Inequality, social capital and health in BolivaWilliam Leonard; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Role of transcription in genomic stabilityPhilip Hanawalt; Fiscal Year: 2008..abstract_text> ..
- GENE REGULATION DURING INTERMITTENT HYPOXIANanduri Prabhakar; Fiscal Year: 2003....
- Efficacy of 25-hydroxyvitamin D3 in colon cancer chemopreventionRajendra G Mehta; Fiscal Year: 2010..The studies will provide a rationale for using 25(OH)D3 for the prevention of colon carcinogenesis. ..
- Brain Imaging in Major Psychoses: Functional ImagingNancy Andreasen; Fiscal Year: 2009..abstract_text> ..
- Facilitators of Motor Recovery Following StrokeGottfried Schlaug; Fiscal Year: 2007..abstract_text> ..
- Function and structure of pendrin in thyroid cellsPeter Kopp; Fiscal Year: 2007..These studies will provide fundamental insights into the (patho)physiology of this novel anion transporter that has important functions in the thyroid, the kidney and the inner ear. ..
- GENETIC AND MOLECULAR BASIS OF BACTERIAL INVASIONStanley Falkow; Fiscal Year: 2007..unreadable] [unreadable]..
- MINORITY BIOMEDICAL RESEARCH TALENT IN PSYCHOLOGYBERTHA HOLLIDAY; Fiscal Year: 2006..d societies; and (f) to document and evaluate the impact of the proposed systemic approach, and its pipeline training procedures on participating institutions and students. [unreadable] [unreadable]..
- CONTROLLING GENE EXPRESSION WITH PEPTIDE NUCLEIC ACIDSDavid Corey; Fiscal Year: 2007..The work proposed here will rigorously test the value of antisense PNAs and our data will shape decisions regarding the use of PNAs for laboratory studies and clinical development. ..
- Eukaryotic Translational Initiation and its RegulationJoseph D Puglisi; Fiscal Year: 2010..The results of this proposal will provide a biophysical context to understanding eukaryotic translation, its regulation, and role in human disease. ..
- Ultrafast Electron Cryomicroscopy of Single Protein ParticlesAhmed H Zewail; Fiscal Year: 2010..If successful, this advance could make structure determination to near-atomic resolution routine for large macromolecular complexes. ..
- Neurotoxic Interactions of Different Forms of MercuryBernard Weiss; Fiscal Year: 2007..The acquisition of these data offers a firm foundation for determining the risks to neurobehavioral development of concurrent exposures to both mercury species. ..
- NALTREXONE AND CBT FOR PATIENTS WITH ALCOHOLISM AND PTSDEdna Foa; Fiscal Year: 2008..Therefore the findings from this study will be highly credible and should impact significantly on treatment recommendations for this impaired population. ..
- The molecular basis of morphological evolutionDavid L Stern; Fiscal Year: 2010..This detailed analysis of gene regulation promises to provide new insights into how gene regulation functions and evolves in natural species to cause possibly adaptive changes in morphology. ..
- Role of Matrix Metalloproteinase-2 in Liver FibrosisMeena Bansal; Fiscal Year: 2007..Findings from these investigations may lead to novel approaches to the treatment of chronic fibrosing liver disease. [unreadable] [unreadable]..
- Heterogeneous Treatment Effects in Social and Behavioral SciencesYu Xie; Fiscal Year: 2010..In addition to scientific articles, a book resulting from the project will be produced that will be accessible to a wide variety of social, behavioral and medical scientists. ..
- ZO-1 & Cytoplasmic Scaffolding of the Tight JunctionJames Anderson; Fiscal Year: 2008..The significance of these results is that they will define basic cellular mechanisms required for TJ assembly, which is fundamental to normal kidney function and altered in disease. ..
- TOTAL SYNTHESIS OF AZADIRACHTINK Nicolaou; Fiscal Year: 2008..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
- CHRONIC MYELOGENOUS LEUKEMIA AND BCR-ABL SUBSTRATESBrian Druker; Fiscal Year: 2009..Combined, these data should offer significant insights into the biology of and the mechanism of transformation by Bcr-Abl. ..
- Mechanisms of chemotherapy-evoked neuropathic painGary Bennett; Fiscal Year: 2009....
- Arterial 5-HT Transporter FunctionStephanie Watts; Fiscal Year: 2009..abstract_text> ..
- HYBRID HYDROGELS SELF-ASSEMBLED FROM GRAFT COPOLYMERSJindrich Kopecek; Fiscal Year: 2008..In addition, the possibility to join non-compatible materials, such as hydrophobic muscle mimics from liquid crystalline polymers and hydrogels, may open a new field of research. ..
- Role of the E3L gene in poxvirus pathogenesisBertram Jacobs; Fiscal Year: 2007..Thus, this work will lead to translation of basic molecular knowledge of E3L function into clinically relevant applications. ..
- FUNCTIONAL NEUROANATOMY OF EMOTIONAL VALENCE AND AROUSALRichard Lane; Fiscal Year: 2003....
- Mucosal Immunization with a Vaccinia Virus-Based VectorBertram Jacobs; Fiscal Year: 2003..Animals will be immunized intra-nasally either with virus alone or as part of a prime-boost regime. Systemic, nasal and vaginal immune responses to the HIV multi-epitope polypeptide will be analyzed. ..
- ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULLKullervo Hynynen; Fiscal Year: 2002..A successful implementation of even one of these possible therapies to routing clinical practice could have a major impact on patient care. ..
- NITRIC OXIDE AND RESPONSES TO HYPOXIA IN DROSOPHILAPATRICK O FARRELL; Fiscal Year: 2003..Similar tools will be developed to dissect the signal transduction pathway that provokes adaptive changes in behavior and cell cycle progression in response to reduced oxygen. ..
- Research Conference:Mutagenesis and CarcinogenesisLAWRENCE MARNETT; Fiscal Year: 2004..Leading scientists in the field will present and evaluate the latest research at the frontiers of mutagenesis and carcinogenesis. ..
- GENE DISCOVERY IN TOXOPLASMA GONDIIL Sibley; Fiscal Year: 2003..In combination with the genetic tools available in T. gondii, this will greatly accelerate investigations into the complex developmental biology of apicomplexan parasites. ..
- The hypocretins and alcohol dependenceLuis de Lecea; Fiscal Year: 2003..The development of these mouse models will generate invaluable tools to assess the role of the hypocretins on drug abuse, and may help to design better treatments for sleep disorders associated with alcoholism. ..
- DNA TOPOISOMERASES--BIOLOGICAL FUNCTIONS & MECHANISMSJames Wang; Fiscal Year: 2003....
- JOB HAZARD ANALYSIS OF SANDBLASTING SUBSTITUTESBeth Rosenberg; Fiscal Year: 2002..abstract_text> ..
- SMITH-LEMLI-OPITZ SYNDROME STEROIDOGENESISCedric Shackleton; Fiscal Year: 2002..Finally, if ring B dehydrosteroids are produced, is the ratio of the individual dehydrometabolites to corresponding conventional metabolites related to the dehydrocholesterol to cholesterol ratio and clinical severity? ..
- EXPERIMENTAL RADIOTHERAPY--BASIS AND MODIFICATIONJohn Brown; Fiscal Year: 2002..To test this hypothesis we will employ inhibitors of the topo II catalytic cycle as well as cells induced to express high levels of topo II following TPZ treatment ..
- TARGETING TO LYMPHOCYTES MEDIATED BY SYNTHETIC EPITOPESJindrich Kopecek; Fiscal Year: 2004..The results of the proposed studies will provide a new method to treat human lymphomas. ..
- Confocal Microscope for MicrobiologyL Sibley; Fiscal Year: 2002..This instrument will greatly strengthen the research programs of these highly productive groups by applying high-resolution confocal microscopy to the study of human pathogens...
- TOTAL SYNTHESIS OF NATURAL PRODUCTSK Nicolaou; Fiscal Year: 2002..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
- Molecular-Genetic Mechanisms for Early-Onset ObesityEvgeny Rogaev; Fiscal Year: 2006..abstract_text> ..
- BUILDING THE TOOTH: BRIDGING BIOLOGY IN MATERIAL SCIENCESMalcolm Snead; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- NEUROPEPTIDE CORTISTATIN AND SLEEPLuis de Lecea; Fiscal Year: 2006..abstract_text> ..
- 9th International Conference on Environmental MutagensPhilip Hanawalt; Fiscal Year: 2005..The new scientific information and insights from this Conference will be of importance to wise policy decisions to protect the public from significant environmental health hazards. ..
- Experimental Intracerebral HemorrhageJustin Zivin; Fiscal Year: 2004..These studies may provide insights about the causes of bleeding and neurological tissue damage that should be helpful in designing even more effective stroke therapies. ..
- Evaluation of the NAGCAT Tractor GuidelinesFadi Fathallah; Fiscal Year: 2005..It is anticipated that once the recommended revisions are incorporated into the NAGCAT, the risks of traumatic and fatal injuries to children due to tractor operation will be reduced. ..
- ACTIVATING MULTIETHNIC YOUTH FOR SMOKING PREVENTIONKaren Glanz; Fiscal Year: 2002..abstract_text> ..
- Ecological Analysis of Physical ActivityJames Sallis; Fiscal Year: 2004..Results will inform public health, land use, and transportation policies that could have population-wide impacts on physical activity. ..
- Plant-Based Dietry Intervention in Type 2 DiabetesNeal Barnard; Fiscal Year: 2004..Glycosylated hemoglobin, insulin concentrations, 24-hour urinary albumin, body weight, blood pressure, serum lipids, and related cardiovascular risk factors will be measured at baseline, 22 weeks, and 74 weeks. ..
- DELETION MUTAGENESIS WITHIN NONCODING SEGMENTS OF HIV1Mark Wainberg; Fiscal Year: 2001..6. To determine whether these attenuated SIV constructs may protect against subsequent challenge with virulent forms of SIV and SIV/HIV hybrids. ..
- NEUROCOMPUTATIONAL ANALYSIS OF LEARNINGTHOMAS CAREW; Fiscal Year: 2001....
- Glucose Regulation of Pancreatic Islet Gene ExperessionRODERICK PAUL ROBERTSON; Fiscal Year: 2010..We will study whether increasing antioxidant protection protects these cells and prevents deterioration of glucose control in diabetes. ..
- CONSEQUENCES OF INHIBITION OF CELLULAR TELOMERASEDavid Corey; Fiscal Year: 2004....
- XRAY STUDIES OF EPO AND IL2 RECEPTOR COMPLEXESIan Wilson; Fiscal Year: 2001..The crystallographic study of IL-2 mutants and various forms of the receptor complex should give insights into the structure and function of this key receptor in T cell growth and proliferation. ..
- Modulation of AMPA-Type Receptor Trafficking in AplysiaDavid Glanzman; Fiscal Year: 2007..Furthermore, the laboratories of the collaborators have the necessary equipment for the proposed research. ..
- Gastrointestinal Eosinophil Research SymposiumGlenn Furuta; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..