ancient history

Summary

Summary: The period of history before 500 of the common era.

Top Publications

  1. ncbi [The Hippocratic Oath: how many covenants, how many oaths?]
    Charlotte Schubert
    Universitat Leipzig, Historisches Seminar, Lehrstuhl für Alte Geschichte, Leipzig
    Medizinhist J 40:247-73. 2005
  2. ncbi Centennial review of corneal transplantation
    S Louise Moffatt
    Department of Ophthalmology, University of Auckland, Auckland, New Zealand
    Clin Experiment Ophthalmol 33:642-57. 2005
  3. ncbi History and current concepts in the analysis of facial attractiveness
    Mounir Bashour
    University of Toronto, Ontario, Canada
    Plast Reconstr Surg 118:741-56. 2006
  4. pmc Coadaptation of Helicobacter pylori and humans: ancient history, modern implications
    John C Atherton
    Nottingham Digestive Diseases Centre Biomedical Research Unit and Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom
    J Clin Invest 119:2475-87. 2009
  5. ncbi The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective
    O Semino
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Science 290:1155-9. 2000
  6. ncbi Comparison of maternal lineage and biogeographic analyses of ancient and modern Hungarian populations
    Gyöngyvér Tömöry
    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, 6726 Szeged, Hungary
    Am J Phys Anthropol 134:354-68. 2007
  7. ncbi Early domesticated fig in the Jordan Valley
    Mordechai E Kislev
    Faculty of Life Sciences, Bar Ilan University, 52900 Ramat Gan, Israel
    Science 312:1372-4. 2006
  8. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
  9. pmc Detection and molecular characterization of 9,000-year-old Mycobacterium tuberculosis from a Neolithic settlement in the Eastern Mediterranean
    Israel Hershkovitz
    Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 3:e3426. 2008
  10. pmc Unravelling migrations in the steppe: mitochondrial DNA sequences from ancient central Asians
    C Lalueza-Fox
    Unitat d Antropologia, Departimenti Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, 08028 Barcelona, Spain
    Proc Biol Sci 271:941-7. 2004

Detail Information

Publications281 found, 100 shown here

  1. ncbi [The Hippocratic Oath: how many covenants, how many oaths?]
    Charlotte Schubert
    Universitat Leipzig, Historisches Seminar, Lehrstuhl für Alte Geschichte, Leipzig
    Medizinhist J 40:247-73. 2005
    ..The article concludes that, as early as the third century A.D., Christian influences played an equally significant role in the transmission of the Oath as pagan influences...
  2. ncbi Centennial review of corneal transplantation
    S Louise Moffatt
    Department of Ophthalmology, University of Auckland, Auckland, New Zealand
    Clin Experiment Ophthalmol 33:642-57. 2005
    ....
  3. ncbi History and current concepts in the analysis of facial attractiveness
    Mounir Bashour
    University of Toronto, Ontario, Canada
    Plast Reconstr Surg 118:741-56. 2006
    ....
  4. pmc Coadaptation of Helicobacter pylori and humans: ancient history, modern implications
    John C Atherton
    Nottingham Digestive Diseases Centre Biomedical Research Unit and Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom
    J Clin Invest 119:2475-87. 2009
    ..These may have contributed to recent increases in esophageal adenocarcinoma and, more speculatively, other modern diseases...
  5. ncbi The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective
    O Semino
    Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Science 290:1155-9. 2000
    ....
  6. ncbi Comparison of maternal lineage and biogeographic analyses of ancient and modern Hungarian populations
    Gyöngyvér Tömöry
    Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, 6726 Szeged, Hungary
    Am J Phys Anthropol 134:354-68. 2007
    ..Modern Hungarian-speaking populations seem to be specifically European. Our findings demonstrate that significant genetic differences exist between the ancient and recent Hungarian-speaking populations, and no genetic continuity is seen...
  7. ncbi Early domesticated fig in the Jordan Valley
    Mordechai E Kislev
    Faculty of Life Sciences, Bar Ilan University, 52900 Ramat Gan, Israel
    Science 312:1372-4. 2006
    ..Hence, fig trees could have been the first domesticated plant of the Neolithic Revolution, which preceded cereal domestication by about a thousand years...
  8. pmc Yersinia pestis--etiologic agent of plague
    R D Perry
    Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
    Clin Microbiol Rev 10:35-66. 1997
    ..These areas of research have provide new insights into the host-parasite relationship. This review will update our present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague...
  9. pmc Detection and molecular characterization of 9,000-year-old Mycobacterium tuberculosis from a Neolithic settlement in the Eastern Mediterranean
    Israel Hershkovitz
    Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 3:e3426. 2008
    ..tuberculosis genomic analysis. Direct examination of ancient human remains for M. tuberculosis biomarkers should aid our understanding of the nature of prehistoric tuberculosis and the host/pathogen relationship...
  10. pmc Unravelling migrations in the steppe: mitochondrial DNA sequences from ancient central Asians
    C Lalueza-Fox
    Unitat d Antropologia, Departimenti Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, 08028 Barcelona, Spain
    Proc Biol Sci 271:941-7. 2004
    ..This study demonstrates the usefulness of the ancient DNA in unravelling complex patterns of past human migrations so as to help decipher the origin of present-day admixed populations...
  11. ncbi Cacao usage by the earliest Maya civilization
    W Jeffrey Hurst
    Hershey Foods Technical Center, PO Box 805, Hershey, Pennsylvania 17033, USA
    Nature 418:289-90. 2002
    ..Our application of this new and highly sensitive analytical technique could be extended to the identification of other ancient foods and beverages...
  12. ncbi The origins of Afroasiatic
    Christopher Ehret
    Science 306:1680; author reply 1680. 2004
  13. ncbi Genetic variation in prehistoric Sardinia
    David Caramelli
    Dipartimento di Biologia Animale e Genetica, Laboratorio di Antropologia, Universita di Firenze, Firenze, Italy
    Hum Genet 122:327-36. 2007
    ....
  14. ncbi Starch fossils and the domestication and dispersal of chili peppers (Capsicum spp. L.) in the Americas
    Linda Perry
    Archaeobiology Program, Department of Anthropology, Smithsonian National Museum of Natural History, Post Office Box 37012, Washington, DC 20013 7012, USA
    Science 315:986-8. 2007
    ..The starch grain assemblages demonstrate that maize and chilies occurred together as an ancient and widespread Neotropical plant food complex that predates pottery in some regions...
  15. ncbi Evolution, consequences and future of plant and animal domestication
    Jared Diamond
    Department of Physiology, University of California Medical School, Los Angeles, 90095 1751, USA
    Nature 418:700-7. 2002
    ....
  16. ncbi On the origin of leprosy
    Marc Monot
    Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
    Science 308:1040-2. 2005
    ..The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years...
  17. ncbi Paleoparasitology of Chagas disease revaled by infected tissues from Chilean mummies
    L F Ferreira
    Fundacao Oswaldo Cruz, Escola Nacional de Saude Publica, Rio de Janeiro, Brazil
    Acta Trop 75:79-84. 2000
    ..cruzi specific molecular probe. The origin and dispersion of T. cruzi human infection is discussed as well as the molecular paleoparasitological approach, and what it may represent in an evolutionary perspective...
  18. ncbi Single, rapid coastal settlement of Asia revealed by analysis of complete mitochondrial genomes
    Vincent Macaulay
    Department of Statistics, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Science 308:1034-6. 2005
    ..There was an early offshoot, leading ultimately to the settlement of the Near East and Europe, but the main dispersal from India to Australia approximately 65,000 years ago was rapid, most likely taking only a few thousand years...
  19. ncbi Dental microwear texture analysis shows within-species diet variability in fossil hominins
    Robert S Scott
    1 Department of Anthropology, University of Arkansas, Fayetteville, Arkansas 72701, USA 2 These authors contributed equally to this work
    Nature 436:693-5. 2005
    ..africanus. This suggests that A. africanus ate more tough foods and P. robustus consumed more hard and brittle items, but that both had variable and overlapping diets...
  20. ncbi Genetic analysis of the skeletal remains attributed to Francesco Petrarca
    David Caramelli
    Dipartimento di Biologia Animale e Genetica, Laboratorio di Antropologia, Universita di Firenze, Via del Proconsolo 12, 50122 Firenze, Italy
    Forensic Sci Int 173:36-40. 2007
    ..These results are consistent with morphological investigations and confirm the importance of integrating molecular and morphological approaches in investigating historical remains...
  21. ncbi Molecular analysis of skeletal tuberculosis in an ancient Egyptian population
    A Zink
    Department of Pathology, , , Germany
    J Med Microbiol 50:355-66. 2001
    ..tuberculosis was relatively frequent in ancient Egypt...
  22. pmc DNA sequences from multiple amplifications reveal artifacts induced by cytosine deamination in ancient DNA
    M Hofreiter
    Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D-04103 Leipzig, Germany
    Nucleic Acids Res 29:4793-9. 2001
    ..1% even under the unlikely scenario where each amplification starts from a single template molecule...
  23. ncbi Farmers and their languages: the first expansions
    Jared Diamond
    Department of Geography, University of California, Los Angeles, CA 90095 1524, USA
    Science 300:597-603. 2003
    ..Further progress will depend on interdisciplinary research that combines archaeology, crop and livestock studies, physical anthropology, genetics, and linguistics...
  24. ncbi First Homo erectus from Turkey and implications for migrations into temperate Eurasia
    John Kappelman
    Department of Anthropology, The University of Texas, Austin, TX 78712 0303, USA
    Am J Phys Anthropol 135:110-6. 2008
    ..Evidence for TB in the new specimen supports the thesis that reduced UVR was one of the many climatic variables presenting an adaptive challenge to ancient hominins during their migration into the temperate regions of Europe and Asia...
  25. pmc A three-stage colonization model for the peopling of the Americas
    Andrew Kitchen
    Department of Anthropology, University of Florida, Gainesville, Florida, USA
    PLoS ONE 3:e1596. 2008
    ..Specifically, we analyze mitochondrial and nuclear genetic data by using complementary coalescent models of demographic history and incorporating non-genetic data to enhance the anthropological relevance of the analysis...
  26. pmc Genotypic analysis of the earliest known prehistoric case of tuberculosis in Britain
    G Michael Taylor
    Department of Infectious Diseases and Microbiology, CMMI, Imperial College of Science, Flowers Building, Armstrong Road, London SW7 2AZ, United Kingdom
    J Clin Microbiol 43:2236-40. 2005
    ..tuberculosis isolates. All evidence obtained was consistent with surviving mycobacterial DNA being highly fragmented in this case...
  27. ncbi Going east: new genetic and archaeological perspectives on the modern human colonization of Eurasia
    Paul Mellars
    Department of Archaeology, Cambridge University, Cambridge CB2 3DZ, UK
    Science 313:796-800. 2006
    ....
  28. ncbi Paleo-Eskimo mtDNA genome reveals matrilineal discontinuity in Greenland
    M Thomas P Gilbert
    Center for Ancient Genetics, Department of Biology, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Science 320:1787-9. 2008
    ..This result suggests that the earliest migrants into the New World's northern extremes derived from populations in the Bering Sea area and were not directly related to Native Americans or the later Neo-Eskimos that replaced them...
  29. ncbi The molecular genetics of crop domestication
    John F Doebley
    Department of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Cell 127:1309-21. 2006
    ....
  30. ncbi The late Pleistocene dispersal of modern humans in the Americas
    Ted Goebel
    Center for the Study of the First Americans, Department of Anthropology, Texas A and M University, 4352 TAMU, College Station, TX 77843 4352, USA
    Science 319:1497-502. 2008
    ..If this is the time of colonization, geological data from western Canada suggest that humans dispersed along the recently deglaciated Pacific coastline...
  31. ncbi Climate-driven ecosystem succession in the Sahara: the past 6000 years
    S Kröpelin
    Africa Research Unit, Institute of Prehistoric Archaeology, University of Cologne, Jennerstrasse 8, D 50823 Köln, Germany
    Science 320:765-8. 2008
    ..P. This gradual rather than abrupt termination of the African Humid Period in the eastern Sahara suggests a relatively weak biogeophysical feedback on climate...
  32. ncbi Climate-controlled Holocene occupation in the Sahara: motor of Africa's evolution
    Rudolph Kuper
    Collaborative Research Center 389 ACACIA, University of Cologne, Institute of Prehistoric Archaeology, Africa Research Unit, Jennerstrasse 8, 50823 Köln, Germany
    Science 313:803-7. 2006
    ..C.E. Southward shifting of the desert margin helped trigger the emergence of pharaonic civilization along the Nile, influenced the spread of pastoralism throughout the continent, and affects sub-Saharan Africa to the present day...
  33. pmc Why did modern human populations disperse from Africa ca. 60,000 years ago? A new model
    Paul Mellars
    Department of Archaeology, Cambridge University, Downing Street, Cambridge CB2 3DZ, England
    Proc Natl Acad Sci U S A 103:9381-6. 2006
    ....
  34. ncbi How Neanderthal molar teeth grew
    Roberto Macchiarelli
    Laboratoire de Géobiologie, Biochronologie et Paléontologie humaine, UMR 6046 CNRS, Universite de Poitiers, 86022 Poitiers, France
    Nature 444:748-51. 2006
    ..These data are the first on internal molar microstructure; they firmly place key Neanderthal life history variables within those known for modern humans...
  35. ncbi Whole-genome shotgun sequencing of mitochondria from ancient hair shafts
    M Thomas P Gilbert
    Centre for Ancient Genetics, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Science 317:1927-30. 2007
    ..The method therefore sets the stage for molecular-genetic analysis of museum collections...
  36. ncbi Ancient DNA provides new insights into the history of south Siberian Kurgan people
    Christine Keyser
    Laboratoire d Anthropologie Moléculaire, Institut de Medecine Legale, Universite de Strasbourg, 11 rue Humann, 67085, Strasbourg Cedex, France
    Hum Genet 126:395-410. 2009
    ..To the best of our knowledge, no equivalent molecular analysis has been undertaken so far...
  37. pmc Genotyping, Orientalis-like Yersinia pestis, and plague pandemics
    Michel Drancourt
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 10:1585-92. 2004
    ..pestis Orientalis. These data indicate that Y. pestis caused cases of Justinian plague. The two historical plague pandemics were likely caused by Orientalis-like strains...
  38. pmc Microfossil evidence for pre-Columbian maize dispersals in the neotropics from San Andres, Tabasco, Mexico
    Mary E D Pohl
    Department of Anthropology, Florida State University, Tallahassee, FL 32306, USA
    Proc Natl Acad Sci U S A 104:6870-5. 2007
    ..Multiple data sets from many sites indicate that maize was brought under cultivation and domesticated and had spread rapidly out of its domestication cradle in tropical southwest Mexico by the eighth millennium before the present...
  39. ncbi Preceramic adoption of peanut, squash, and cotton in northern Peru
    Tom D Dillehay
    Department of Anthropology, Vanderbilt University, Nashville, TN 37221, USA
    Science 316:1890-3. 2007
    ..These data provide evidence for early use of peanut and squash in the human diet and of cotton for industrial purposes and indicate that horticultural economies in parts of the Andes took root by about 10,000 years ago...
  40. ncbi Mosaics of ancient mitochondrial DNA: positive indicators of nonauthenticity
    Hans Jurgen Bandelt
    Fachbereich Mathematik, Universitat Hamburg, Hamburg, Germany
    Eur J Hum Genet 13:1106-12. 2005
    ..To reject or question authenticity of particular sequencing results a posteriori, one can follow similar strategies of focused database comparisons that have proven to be effective and successful in the case of flawed modern mtDNA data...
  41. pmc Cattle domestication in the Near East was followed by hybridization with aurochs bulls in Europe
    Anders Götherström
    Evolutionary Biology Centre, Uppsala University, Department of Evolutionary Biology, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Proc Biol Sci 272:2345-50. 2005
    ..Rather than originating from a few geographical areas only, as indicated by mtDNA, our data suggest that the origin of domestic cattle may be far more complex than previously thought...
  42. pmc Characterization of Mycobacterium tuberculosis complex DNAs from Egyptian mummies by spoligotyping
    Albert R Zink
    Division of Palaeopathology, Institute of Pathology, Academic Teaching Hospital München Bogenhausen, D 81925 Munich, Germany
    J Clin Microbiol 41:359-67. 2003
    ..In addition, our results do not support the theory that M. tuberculosis originated from the M. bovis type but, rather, suggest that human M. tuberculosis may have originated from a precursor complex probably related to M. africanum...
  43. ncbi Alexander the Great, seafaring, and the spread of leprosy
    Samuel Mark
    Texas A and M University at Galvestion, USA
    J Hist Med Allied Sci 57:285-311. 2002
  44. pmc Mitochondrial DNA analysis shows a Near Eastern Neolithic origin for domestic cattle and no indication of domestication of European aurochs
    Ceiridwen J Edwards
    Smurfit Institute of Genetics, Trinity College, Dublin 2, Ireland
    Proc Biol Sci 274:1377-85. 2007
    ..During the period of coexistence, it appears that domestic cattle were kept separate from wild aurochs and introgression was extremely rare...
  45. pmc Contrasting patterns in crop domestication and domestication rates: recent archaeobotanical insights from the Old World
    Dorian Q Fuller
    Institute of Archaeology, University College London, 31 34 Gordon Square, London WC1H 0PY, UK
    Ann Bot 100:903-24. 2007
    ..These traits include features that have been selected under the conditions of cultivation. From archaeological remains the easiest traits to study are seed size and in cereal crops the loss of natural seed dispersal...
  46. ncbi Stratigraphic placement and age of modern humans from Kibish, Ethiopia
    Ian McDougall
    Research School of Earth Sciences, Australian National University, Canberra, ACT 0200, Australia
    Nature 433:733-6. 2005
    ..Our preferred estimate of the age of the Kibish hominids is 195 +/- 5 kyr, making them the earliest well-dated anatomically modern humans yet described...
  47. pmc Alexander the Great and West Nile virus encephalitis
    John S Marr
    Virginia Department of Health, Richmond, VA, USA
    Emerg Infect Dis 9:1599-603. 2003
    ..We posit that Alexander may have died of West Nile virus encephalitis...
  48. ncbi Redefining the age of Clovis: implications for the peopling of the Americas
    Michael R Waters
    Departments of Anthropology and Geography, Center for the Study of the First Americans, Texas A and M University, 4352 TAMU, College Station, TX 77843 4352, USA
    Science 315:1122-6. 2007
    ..The revised age range for Clovis overlaps non-Clovis sites in North and South America. This and other evidence imply that humans already lived in the Americas before Clovis...
  49. ncbi Tuberculosis: from prehistory to Robert Koch, as revealed by ancient DNA
    Helen D Donoghue
    Centre for Infectious Diseases and International Health, University College London, London, UK
    Lancet Infect Dis 4:584-92. 2004
    ..This has provided direct support for the current theory of Mycobacterium tuberculosis evolution, and suggests areas of investigation for the interaction of M tuberculosis with its host...
  50. ncbi Mitochondrial DNA and Y chromosome diversity and the peopling of the Americas: evolutionary and demographic evidence
    Theodore G Schurr
    Department of Anthropology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Hum Biol 16:420-39. 2004
    ..Finally, populations that formerly inhabited Beringia expanded into northern North America after the LGM, and gave rise to Eskimo-Aleuts and Na-Dené Indians...
  51. ncbi Population affinities of Neolithic Siberians: a snapshot from prehistoric Lake Baikal
    K P Mooder
    Human Identification Laboratory for Archaeology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2G3, Canada
    Am J Phys Anthropol 129:349-61. 2006
    ..These results suggest that the Lake Baikal region experienced a significant depopulation event during the sixth millennium BP, and was reoccupied by a new immigrant population some 800 years later...
  52. ncbi Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the Americas
    Brian M Kemp
    Department of Anthropology, Vanderbilt University, Nashville, TN 37235 7703, USA
    Am J Phys Anthropol 132:605-21. 2007
    ..In addition, this individual's Y-chromosome belongs to haplogroup Q-M3*, placing a minimum date of 10,300 years ago for the emergence of this haplogroup...
  53. ncbi How fast was wild wheat domesticated?
    Ken Ichi Tanno
    Research Institute for Humanity and Nature, Takashima 335, Kamigyo, 602 0878 Kyoto, Japan
    Science 311:1886. 2006
    ..Slow domestication implies that after cultivation began, wild cereals may have remained unchanged for a long period, supporting claims that agriculture originated in the Near East approximately 10,500 years before the present...
  54. ncbi Anthropology. Autonomous cultivation before domestication
    Ehud Weiss
    Martin Szusz Department of Land of Israel Studies and Archaeology and Faculty of Life Sciences, Bar Ilan University, 52900 Ramat Gan, Israel
    Science 312:1608-10. 2006
  55. ncbi Tracking down human contamination in ancient human teeth
    Maria Lourdes Sampietro
    Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Biol Evol 23:1801-7. 2006
    ..We argue therefore that the typing of those involved in the manipulation of the ancient human specimens is critical in order to ensure that generated results are accurate...
  56. ncbi The last Viking King: a royal maternity case solved by ancient DNA analysis
    Jørgen Dissing
    Research Laboratory, Institute of Forensic Medicine, University of Copenhagen, Frederik V Vej 11, DK 2100 Copenhagen, Denmark
    Forensic Sci Int 166:21-7. 2007
    ..Although the entombed woman cannot be the Estrid, she may well be one of Sven's two daughters-in-law who were also called Estrid and who both became queens...
  57. ncbi The tempo of avian diversification: a comment on Johnson and Cicero
    Robert M Zink
    Bell Museum, University of Minnesota, St Paul, Minnesota 55108, USA
    Evolution 60:411-2; discussion 413-4. 2006
    ..Therefore, our analysis of Johnson and Cicero's data suggests that the late Pleistocene was no more important for avian speciation than any other time during this time period...
  58. ncbi Weak climatic control of stand-scale fire history during the late holocene
    Daniel G Gavin
    Department of Plant Biology, University of Illinois, Urbana, Illinois 61801, USA
    Ecology 87:1722-32. 2006
    ....
  59. pmc Sequencing and analysis of Neanderthal genomic DNA
    James P Noonan
    U S Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
    Science 314:1113-8. 2006
    ..This initial analysis of the Neanderthal genome advances our understanding of the evolutionary relationship of Homo sapiens and Homo neanderthalensis and signifies the dawn of Neanderthal genomics...
  60. ncbi Leprosy and tuberculosis in Iron Age Southeast Asia?
    N Tayles
    Department of Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Am J Phys Anthropol 125:239-56. 2004
    ....
  61. ncbi Evolution. Did early humans go north or south?
    Peter Forster
    McDonald Institute for Archaeological Research, University of Cambridge, Cambridge CB2 3ER, UK
    Science 308:965-6. 2005
  62. ncbi First report of Mycobacterium bovis DNA in human remains from the Iron Age
    G Michael Taylor
    Centre for Molecular Microbiology and Infectious Diseases, Imperial College of Science, Technology and Medicine, London, UK
    Microbiology 153:1243-9. 2007
    ..Moreover, it shows that loss of DNA from RD4, which defines classic M. bovis, had already occurred from the genome over 2000 years before the present...
  63. ncbi Ancient DNA-typing approaches for the determination of kinship in a disturbed collective burial site
    T Schultes
    Institute of Zoology and Anthropology, University of Gottingen
    Anthropol Anz 58:37-44. 2000
    ..In a bronze age collective site, the typing methods were tested for applicability to ancient DNA. For each approach, results were obtained, leading to the conclusion that the determination of kinship is achievable...
  64. pmc Y-SNPs do not indicate hybridisation between European aurochs and domestic cattle
    Ruth Bollongino
    Palaeogenetics Group, Institute of Anthropology, Johannes Gutenberg University Mainz, Mainz, Germany
    PLoS ONE 3:e3418. 2008
    ..To test their hypothesis, we applied these Y-markers on Neolithic bone specimens from various European archaeological sites...
  65. ncbi Starch grains reveal early root crop horticulture in the Panamanian tropical forest
    D R Piperno
    Smithsonian Tropical Research Institute, Ancon, Balboa, Republic of Panama
    Nature 407:894-7. 2000
    ..The data provide the earliest direct evidence for root crop cultivation in the Americas, and support an ancient and independent emergence of plant domestication in the lowland Neotropical forest...
  66. ncbi Ancient DNA from the first European farmers in 7500-year-old Neolithic sites
    Wolfgang Haak
    Institut für Anthropologie, Johannes Gutenberg Universitat Mainz, Saarstrasse 21, D 55099 Mainz, Germany
    Science 310:1016-8. 2005
    ..2%) of this mtDNA type, revealing that these first Neolithic farmers did not have a strong genetic influence on modern European female lineages. Our finding lends weight to a proposed Paleolithic ancestry for modern Europeans...
  67. pmc Mitochondrial genome diversity of Native Americans supports a single early entry of founder populations into America
    Wilson A Silva
    Center for Cell Therapy and Regional Blood Center, University of Sao Paulo, Ribeirao Preto, Brazil
    Am J Hum Genet 71:187-92. 2002
    ....
  68. ncbi Mycobacterium tuberculosis complex DNA from an extinct bison dated 17,000 years before the present
    B M Rothschild
    Arthritis Center of Northeast Ohio, 5500 Market St, Youngstown, OH 44512, USA
    Clin Infect Dis 33:305-11. 2001
    ..Extensive precautions against contamination with modern M. tuberculosis complex DNA were employed, including analysis of paleontologic and modern specimens in 2 geographically separate laboratories...
  69. pmc Patterns of damage in genomic DNA sequences from a Neandertal
    Adrian W Briggs
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 104:14616-21. 2007
    ..The results suggest that reliable genome sequences can be obtained from Pleistocene organisms...
  70. ncbi Inca expansion and parasitism in the lluta valley: preliminary data
    Calogero Santoro
    Museo Arqueológico San Miguel de Azapa, Universidad de Tarapaca, Arica, Chile
    Mem Inst Oswaldo Cruz 98:161-3. 2003
    ..Changes in parasite prevalence are described. It can be seen that the change in life imposed on the inhabitants of the Lluta Valley by the Incas caused an increase in parasitism...
  71. pmc Nuclear and mitochondrial DNA analysis of a 2,000-year-old necropolis in the Egyin Gol Valley of Mongolia
    Christine Keyser-Tracqui
    Laboratoire d Anthropologie Moléculaire, Institut de Medecine Legale, Strasbourg, France
    Am J Hum Genet 73:247-60. 2003
    ..To the best of our knowledge, this is the first study using biparental, paternal, and maternal genetic systems to reconstruct partial genealogies in a protohistoric necropolis...
  72. ncbi Tracing the genetic history of the Chinese people: mitochondrial DNA analysis of aneolithic population from the Lajia site
    Shi Zhu Gao
    Laboratory of Ancient DNA, Research Center for Chinese Frontier Archaeology of Jilin University, Changchun 130012, China
    Am J Phys Anthropol 133:1128-36. 2007
    ..This study, combined with archaeological and anthropological investigations, provides a better understanding of the genetic history of the Chinese people...
  73. pmc A 9,000-year record of Chagas' disease
    Arthur C Aufderheide
    Paleobiology Laboratory, Department of Pathology, University of Minnesota, Duluth School of Medicine, Duluth, MN 55812, USA
    Proc Natl Acad Sci U S A 101:2034-9. 2004
    ....
  74. ncbi Genomic sequencing of Pleistocene cave bears
    James P Noonan
    United States Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA
    Science 309:597-9. 2005
    ..Comparison of cave bear and modern bear sequences revealed the evolutionary relationship of these lineages. The metagenomic approach used here establishes the feasibility of ancient DNA genome sequencing programs...
  75. ncbi Africa's wild C4 plant foods and possible early hominid diets
    Charles R Peters
    Anthropology Department and Institute of Ecology, Baldwin Hall, University of Georgia, Athens, Georgia 30602 1619, USA
    J Hum Evol 48:219-36. 2005
    ..CAM plants may have a more ancient history, but offer few opportunities for an additional C4-like dietary signal...
  76. ncbi Health of infants in an Imperial Roman skeletal sample: perspective from dental microstructure
    Charles Fitzgerald
    Department of Anthropology, McMaster University, Hamilton, Ontario L8S 4L9, Canada
    Am J Phys Anthropol 130:179-89. 2006
    ..These results are discussed in light of historical records of Roman childhood rearing practices...
  77. ncbi Frequency of pathology in a large natural sample from Natural Trap Cave with special remarks on erosive disease in the Pleistocene
    B M Rothschild
    The Arthritis Center of Northeast Ohio, Youngstown, OH 44512, USA
    Reumatismo 55:58-65. 2003
    ..Tooth breakage due to errors in bone manipulation was a problem for carnivores and one lion, Pantera atrox, was apparently reduced by joint disease to a scavenging lifestyle...
  78. pmc Co-infection of Mycobacterium tuberculosis and Mycobacterium leprae in human archaeological samples: a possible explanation for the historical decline of leprosy
    Helen D Donoghue
    Centre for Infectious Diseases and International Health, Department of Infection, University College London, 46 Cleveland Street, London W1T 4JF, UK
    Proc Biol Sci 272:389-94. 2005
    ....
  79. ncbi Drug addiction. Part I. Psychoactive substances in the past and presence
    J Vetulani
    Institute of Pharmacology, Polish Academy of Sciences,
    Pol J Pharmacol 53:201-14. 2001
    ..The substance abuse approaches the level of global epidemics, and the recent usage of drugs of addition is also reviewed...
  80. ncbi Palaeolithic paintings. Evolution of prehistoric cave art
    H Valladas
    Laboratoire des Sciences du Climat et de l Environnement, UMR CEA CNRS 1572, 91198 Gif sur Yvette Cedex, France
    Nature 413:479. 2001
    ..Prehistorians, who have traditionally interpreted the evolution of prehistoric art as a steady progression from simple to more complex representations, may have to reconsider existing theories of the origins of art...
  81. ncbi Anthropological and palaeopathological analysis of the human remains from three "Tombs of the Nobles" of the necropolis of Thebes-west, upper Egypt
    A Nerlich
    Institute of Pathology, Ludwig Maximilians Universitat Munchen
    Anthropol Anz 58:321-43. 2000
    ..This is somewhat in contrast to the usually assumed high standard of living of the socially higher population of the capital of ancient Egypt...
  82. ncbi Plant science. Unfallen grains: how ancient farmers turned weeds into crops
    John Doebley
    Laboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Science 312:1318-9. 2006
  83. ncbi Breastfeeding--was a life line in the past and still is!
    Yngve Hofvander
    Department of Women s and Children s Health, Uppsala University, Sweden
    Ups J Med Sci 111:17-25. 2006
  84. ncbi Old-growth forests as global carbon sinks
    Sebastiaan Luyssaert
    Department of Biology, University of Antwerp, 2610 Wilrijk, Belgium
    Nature 455:213-5. 2008
    ..Old-growth forests accumulate carbon for centuries and contain large quantities of it. We expect, however, that much of this carbon, even soil carbon, will move back to the atmosphere if these forests are disturbed...
  85. ncbi [Brain, mind and symptoms]
    E García-Albea Ristol
    Seccion de Neurologia, Universidad de Alcala, Hospital Principe de Asturias, Alcala de Henares, Madrid, Spain
    Rev Neurol 42:439-43. 2006
    ....
  86. ncbi Bacillus (corynebacterium) xerosis and the ocular surface
    Juan Murube
    University of Alcala Madrid, Spain
    Ocul Surf 4:6-9. 2006
  87. ncbi Embracing bioethics in neonatal intensive care, part I: evolving toward neonatal evidence-based ethics
    Isabell B Purdy
    NICU Clinical Research and HRI Follow Up, David Geffen School of Medicine, UCLA, Division of Neonatology and Developmental Biology, Los Angeles, CA 90095 1752, USA
    Neonatal Netw 25:33-42. 2006
    ..It also includes recommendations for enhancing the skills of neonatal nurses as patient advocates in NICU ethical issues, an area that is, at times, controversial and baffling to clinicians...
  88. ncbi Hemodynamic profiles of heart failure patients and "elementary qualities" of pre-hippocratic medicine: a hypothesis for a linguistic and epistemological relationship
    Gian Franco Gensini
    Med Hypotheses 66:1246-8. 2006
  89. doi Nutrition and fitness from the first Olympiad in 776 BC to the 21st century and the concept of positive health
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    World Rev Nutr Diet 98:1-22. 2008
  90. ncbi A 2,000-year record of mercury and ancient civilizations in seal hairs from King George Island, West Antarctica
    Liguang Sun
    Institute of Polar Environment, University of Science and Technology of China, Hefei, Anhui 230026, PR China
    Sci Total Environ 368:236-47. 2006
    ....
  91. ncbi A comparison of antimony and lead profiles over the past 2500 years in Flanders Moss ombrotrophic peat bog, Scotland
    Joanna M Cloy
    School of Geosciences, The University of Edinburgh, West Mains Road, Edinburgh, UKEH9 3JJ
    J Environ Monit 7:1137-47. 2005
    ....
  92. ncbi Lithogenic, oceanic and anthropogenic sources of atmospheric Sb to a maritime blanket bog, Myrarnar, Faroe Islands
    William Shotyk
    Institute of Environmental Geochemistry, University of Heidelberg, INF 236, D 69120, Heidelberg, Germany
    J Environ Monit 7:1148-54. 2005
    ....
  93. pmc The history of anatomy in Persia
    Mohammadali M Shoja
    Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    J Anat 210:359-78. 2007
    ..Knowledge of anatomy for this region in the 20th century was greatly influenced by Europe and America...
  94. ncbi Comment on Martínez-García et al. "Heavy metals in human bones in different historical epochs"
    Andrew Millard
    Sci Total Environ 354:295-7; author reply 298-302. 2006
    ..Lifetime heavy metal exposure cannot be deduced from diagenetically altered concentrations...
  95. ncbi Implications of biosimilars for the future
    Philip E Johnson
    H Lee Moffitt Cancer Center, 12902 Magnolia Dr, Tampa, FL 33612 9497, USA
    Am J Health Syst Pharm 65:S16-22. 2008
    ....
  96. ncbi Traditional Korean medicine: now and the future
    Kang Hyun Leem
    College of Korean Medicine, Semyung University, Jechon 390 711, Korea
    Neurol Res 29:S3-4. 2007
    ..It has developed unique medical theories and methods to treat diseases including neurological disorders such as stroke, epilepsy and Parkinson's disease...
  97. ncbi Male circumcision through the ages: the role of tradition
    Nicola Zampieri
    Department of Surgical Sciences, Pediatric Surgical Unit, University of Verona, Verona, Italy
    Acta Paediatr 97:1305-7. 2008
    ..In this study, we examine the evolution of tradition concerning infant male circumcision, utilizing evidence from classical medical texts as well as information from literature, legal sources and art...
  98. ncbi Reading our lips: the history of lipstick regulation in Western seats of power
    Sarah E Schaffer
    Food Drug Law J 62:165-225. 2007
  99. ncbi Numeric expression of aesthetics and beauty
    B S Atiyeh
    Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon
    Aesthetic Plast Surg 32:209-16; discussion 217-9. 2008
    ....
  100. pmc Global climate change, war, and population decline in recent human history
    David D Zhang
    Department of Geography, University of Hong Kong, Pokfulam Road, Hong Kong
    Proc Natl Acad Sci U S A 104:19214-9. 2007
    ..Findings of this research may lend an additional dimension to the classic concepts of Malthusianism and Darwinism...
  101. ncbi [Origin and evolution of the terms "german" and "German" (II)]
    D P Mertz
    Versicherungsmedizin 59:146-9. 2007

Research Grants63

  1. TOLL RECEPTORS AND CONTROL OF MAMMALIAN IMMUNITY
    Ruslan Medzhitov; Fiscal Year: 2005
    ..Our ultimate goal is to understand whether activation of different TLRs results in the induction of distinct cellular and immune responses. ..
  2. Medicinal Plants of Antiquity: A Computerized Database
    Alain Touwaide; Fiscal Year: 2007
    ..These secondary databases will be linked to the primary database so that users of the primary database can consult at any moment the necessary information for a better understanding of ancient texts. [unreadable] [unreadable]..
  3. DETERMINANTS OF VISUAL PERCEPTION
    LEON FESTINGER; Fiscal Year: 1980
    ..see how information about the evolutionary, cultural and social history of humans, as inferred from paleontology, archaeology, ancient history and anthropology, can help us to create a theoretical, large context about human psychology.
  4. Genetics of Variation for Complex Traits
    John Doebley; Fiscal Year: 2007
    ..5) Finally, we will analyze the patterning of genetic diversity in genomic regions that have experienced recent and strong selective sweeps to understand how the genome responds to past selective pressure. ..
  5. Columbia-GHI Consortium for Claims-Based Cancer Studies
    STEVEN STELLMAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  6. Palliative Care Curriculum for 3rd-Year Medical Students
    Charles von Gunten; Fiscal Year: 2007
    ..Data will be compared with residents who have not been through the course as well as with residents and faculty participating in another study of education. ..
  7. Latino Eye Health: A Communication Strategy for Diabetes
    Sheila West; Fiscal Year: 2007
    ..Improvements in eye care seeking behaviors should help in avoiding visual loss from diabetic retinopathy and macula edema, the leading causes of visual loss in the working age Latino population. [unreadable] [unreadable]..
  8. Vitamin D insufficiency: Prevalence and Impact in Young School Age Children
    Kumaravel Rajakumar; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. Neuromodulatory Effects of Ginkgolides and Bilobalide
    Koji Nakanishi; Fiscal Year: 2007
    ..These studies can potentially provide new targets for terpene trilactones in the central nervous system that require the synthesis of new ginkgolide and bilobalide ligands. [unreadable] [unreadable]..
  10. Interstitial Cystitis Clinical Research Network (ICCRN)
    J Nickel; Fiscal Year: 2007
    ..site with Dr. Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with IC in clinical strudies and will be a valuable partner in the proposed ICCRN and UCPPSCG. ..
  11. TLR4 as an LPS sendor and susceptibility locus
    Bruce Beutler; Fiscal Year: 2007
    ..The new mutations that are found--and those that have already been found in preliminary efforts--will be isolated by positional cloning. ..
  12. A Selective Approach to Metastatic Gene Discovery
    Carlos Barbas; Fiscal Year: 2006
    ..The net result of this study should be an increased understanding of the cell biology of metastasis and the discovery of novel molecular targets for diagnostic, prognostic and therapeutic application. ..
  13. CENTER FOR RESEARCH IN OLDER PEOPLE WITH PSYCHOSES
    Dilip Jeste; Fiscal Year: 2006
    ....
  14. Cataract: Health Disparity for Older African-Americans
    Sheila West; Fiscal Year: 2006
    ..These data will advance the goal of reducing health disparity in visual disability from cataract among older African Americans. ..
  15. Sublingual Buprenorphine for Chronic Pain in Patients at Risk for Drug Abuse
    Andrew Rosenblum; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. DVD Consent for Research in Older Schizophrenia Patients
    Dilip Jeste; Fiscal Year: 2008
    ..The DVD-based consent is not intended to supplant, but rather to supplement, the researcher-participant in-person interaction involved in consent process. ..
  17. Integrated Parametric and Non-parametric Mapping for Genome-Wife Association Data
    GONCALO ROCHA ABECASIS; Fiscal Year: 2008
    ..The resulting data, together with genotype data from at least two other genome-wide association scans, will allow us to evaluate and calibrate our methods for association mapping. [unreadable] [unreadable] [unreadable] [unreadable]..
  18. New Paradigms of Cerebral Palsy Etiology: A Comprehensive Case Control Study
    NIGEL SEFTON PANETH; Fiscal Year: 2010
    ..Maternal interviews and birth certificates will inform the above analyses by linking molecular information to self-reported and recorded clinical events and conditions. ..
  19. GENERAL CLINICAL RESEARCH CENTER
    Kevin J Tracey; Fiscal Year: 2010
    ..This proposal seeks continued funding for the Feinstein GCRC by NCRR. ..
  20. The Effect of Statins on Skeletal Muscle Function
    PAUL DAVIS THOMPSON; Fiscal Year: 2010
    ....
  21. Transcriptional Blockades of HIV-1
    Carlos F Barbas; Fiscal Year: 2010
    ..The new approach we develop will be applicable to other diseases. ..
  22. Computational and Statistical Models for Human Pedigrees
    GONCALO ROCHA ABECASIS; Fiscal Year: 2008
    ..abstract_text> ..
  23. Gene Mapping of Complex Traits Using Resequencing Data
    GONCALO ROCHA ABECASIS; Fiscal Year: 2010
    ..Here, we propose to develop efficient methods for analyzing high-throughput sequence data and to distribute software tools that allow others to extract maximum benefit from our methods. ..
  24. Antepartum Interpersonal Psychotherapy at 3 NYC Sites
    Margaret Spinelli; Fiscal Year: 2009
    ..Co-investigators are maternal fetal medicine faculty from respective sites who will be primary liaison to the respective departments of obstetrics and provide clinical obstetrical needs of the study. ..
  25. THE DETERMINANTS OF INFANT MORTALITY: STATISTICAL MODELS
    TIMOTHY GAGE; Fiscal Year: 2009
    ..We will develop and make available programs for conducting Covariate Density Defined mixtures of GLMs. ..
  26. Academic Palliative Care
    Charles von Gunten; Fiscal Year: 2008
    ..All reentered investigators are seeking NCI funding and have the potential to become independent investigators. ..
  27. Yearly Mass Treatment C. Trachomatis: When Can We Stop?
    Sheila West; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  28. Who drives safely? Visual/cognitive predictors in Elders
    Sheila West; Fiscal Year: 2008
    ..This study will provide critical data on the interactive role of vision, visual attention, and cognition in changing older persons driving behaviors, and the resulting effect on driver errors and risk of crashes. ..
  29. Mutagenic analysis of LPS responses
    Bruce Beutler; Fiscal Year: 2006
    ..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection. ..
  30. Genetic Architecture of the Baboon Craniofacial Complex
    RICHARD SHERWOOD; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  31. STUDIES OF NATURAL PRODUCTS BY CHIROPTICAL METHODS
    Koji Nakanishi; Fiscal Year: 2004
    ..This will include CD studies of retinal/opsin in rhodopsin and retinal/bacterioopsin in bacteriorhodopsin. Vinca alkaloid/tubulin and taxoid/tubulin complexes will be analyzed by FDCD. ..
  32. A Mouse Model of Gaucher Disease
    Ernest Beutler; Fiscal Year: 2005
    ..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
  33. DEPRESSION, 5-HT1A RECEPTOR & NEUROPLASTICITY
    Efrain Azmitia; Fiscal Year: 2005
    ..The applicant will focus on dendritic collapse and apoptosis of neurons. This work will continue our long-term research into the interactions between serotonin and adult neumplasticity. ..
  34. LATE ONSET SCHIZOPHRENIA--A NEUROPSYCHIATRIC STUDY
    Dilip Jeste; Fiscal Year: 2002
    ..g., MRI quantitative analysis, outcome and functioning measures) to the new questions being asked. Our studies should have a major impact on the understanding of schizophrenia and aging. ..
  35. Targeted Activation of Fetal Hemoglobin
    Carlos Barbas; Fiscal Year: 2004
    ..It is anticipated that the results of this work will provide a novel approach to study the molecular mechanisms of hemoglobinopathies as well as new strategies to treat them. ..
  36. Human Subjects Research Enhancements Program
    Richard Rivlin; Fiscal Year: 2003
    ..The ongoing collaborations of IFCP and South Carolina will be greatly strengthened by the completion of upgrading procedures for protection of human subjects by funding the second year of support of this grant program. ..
  37. ENDOGENOUS GENE REGULATION FOR CANCER AND ANGIOGENESIS
    Carlos Barbas; Fiscal Year: 2004
    ..It is anticipated that the results of this work will provide researchers with novel tools to study the molecular mechanisms of disease as well as a new strategy to treat it. ..
  38. INTERVENTIONS FOR VISUAL LOSS IN NURSING HOME RESIDENTS
    Sheila West; Fiscal Year: 2002
    ..This trial will answer timely questions of the impact on the functional status of the most frail elderly of modest, potentially sustainable inputs into improving the appropriate utilization of eye care services. ..
  39. CHARACTERIZATION & TREATMENT OF CATEGORY III PROSTATITIS
    J Nickel; Fiscal Year: 2003
    ..Results from this 3 part study will be analyzed and correlated between groups and within groups, both concurrently and sequentially. ..
  40. NEUROLEPTIC-INDUCED MOVEMENT DISORDERS IN OLDER PATIENTS
    Dilip Jeste; Fiscal Year: 2003
    ..We believe that our findings will have major therapeutic implications for the use of antipsychotics, particularly in older patients. ..
  41. AMD AND RISK FACTORS IN A HISPANIC POPULATION
    Sheila West; Fiscal Year: 2003
    ..Such data will advance our understanding of the magnitude of AMD in this ethnic group, and the way in which risk factors relate to AMD in different populations. ..
  42. MENTAL HEALTH 5 HTIA RECEPTOR AND NEUROPLASTICITY
    Efrain Azmitia; Fiscal Year: 2005
    ....
  43. Metabolism of Carcinogens and Drugs by Human P450s
    F Guengerich; Fiscal Year: 2005
    ..Successful completion of these collective studies should provide better understanding of the ways in which human P450s catalyze oxidation of carcinogens and drugs and the significance of variations in these enzymes. ..
  44. Forward Genetic Analysis of the Innate Immune Contribution to MCMV Resistance
    Bruce Beutler; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  45. Mechanisms for neurocognitive damage of HIV+ drug users
    Raul Gonzalez; Fiscal Year: 2006
    ..abstract_text> ..
  46. ENCODING IN SOMATIC SENSE ORGANS
    EDWARD PERL; Fiscal Year: 2001
    ..N.S? This information, in an area which has been barely explored, could greatly improve our understanding of how mechanical events are sensed. This could open up new areas of inquiry of possible importance in sensory deficits. ..
  47. STUDIES ON RHODOPSIN & AGE-RELATED MACULAR DEGENERATION
    Koji Nakanishi; Fiscal Year: 2006
    ..abstract_text> ..
  48. Spontaneous Arousals in "CHIME" Infants at Risk for SIDS
    ROBERT DARNALL; Fiscal Year: 2006
    ..Finally, we will examine the relationships among the level of arousal, post-conceptional age, sleep state, and other infant behaviors such as feeding that are also associated with changes in autonomic activity. ..
  49. ANIMAL MODELS OF EXTREME HYPERPHAGIA AND HIGH METABOLISM
    Jared Diamond; Fiscal Year: 2001
    ....
  50. The Angiotensinogen Gene and Human Hypertension
    Lynn Jorde; Fiscal Year: 2006
    ..In summary, our extensive analysis of AGT variation in more than 1,600 subjects will clarify the role of this gene in essential hypertension and will test specific hypotheses about the evolution of AGT. ..
  51. EARLY EVENTS IN NEURAL AND HOMEOGENETIC INDUCTION
    Claudio Stern; Fiscal Year: 2005
    ..D. To explore the possible roles of 6 newly-identified candidate secreted factors in the early steps of neural induction and homeogenetic induction. ..
  52. FORMATION AND SURVIVAL OF RED BLOOD CELLS
    Ernest Beutler; Fiscal Year: 2001
    ..Should these point mutations fail to alter gene transcription, a search will be made for other potential mutations in linkage disequilibrium with the known -5,-8 and -24 polymorphisms, by sequencing upstream through the promotor. ..
  53. IN VITRO EVOLUTION OF HUMAN ANTIHIV ANTIBODIES
    Carlos Barbas; Fiscal Year: 2002
    ....
  54. AGING AND DEMENTIA--LONGITUDINAL COURSE OF SUBGROUPS
    Barry Reisberg; Fiscal Year: 2002
    ..Collectively, these cohorts include over 1300 persons. The comprehensive evaluations include behavioral, mental status, neuropsychologic, neurologic, neuroimaging, electrophysiologic, and postmortem studies. ..
  55. TRIAL OF ANTIBIOTICS TO REDUCE RECURRENT TRICHIASIS
    Sheila West; Fiscal Year: 2005
    ..abstract_text> ..
  56. SPINAL AND PROJECTION MECHANISMS RELATED TO PAIN
    EDWARD PERL; Fiscal Year: 2008
    ..Immunocytochemical studies will be used to complement the structural and pharmacological analyses to aid in establishing mediators involved in linkages between SDH neurons. ..
  57. COOPERATIVE CORE LAB AND CLINICAL NUTRITION RESEARCH
    Richard Rivlin; Fiscal Year: 2006
    ..abstract_text> ..
  58. Metabolic Effects of Newer Antipsychotics in Older Pts
    Dilip Jeste; Fiscal Year: 2009
    ..abstract_text> ..
  59. Evolution of BMP Genes 2 and 4 in Archosaurs
    CHRIS ORGAN; Fiscal Year: 2007
    ..Aim three is to elucidate the evolution of bmp2 and bmp4 coding regions. This project will be the first large scale examination of non-avian reptile genome structure and evolution. ..
  60. Endothelial Cell in Progressive Renal Disease
    Richard Johnson; Fiscal Year: 2009
    ..abstract_text> ..
  61. AASK Cohort Study
    Shaul Massry; Fiscal Year: 2007
    ..Such results might eventually lead to new strategies that delay or prevent ESRD. ..
  62. Role of Inter-alpha Inhibitors in Anthrax Intoxication
    Steven Opal; Fiscal Year: 2007
    ..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..