Genomes and Genes
Summary: The period of history before 500 of the common era.
Articles from Journal RESEARCH
Articles from Journal RESEARCH1
Publications281 found, 100 shown here
- [The Hippocratic Oath: how many covenants, how many oaths?]Charlotte Schubert
Universitat Leipzig, Historisches Seminar, Lehrstuhl für Alte Geschichte, Leipzig
Medizinhist J 40:247-73. 2005..The article concludes that, as early as the third century A.D., Christian influences played an equally significant role in the transmission of the Oath as pagan influences...
- Centennial review of corneal transplantationS Louise Moffatt
Department of Ophthalmology, University of Auckland, Auckland, New Zealand
Clin Experiment Ophthalmol 33:642-57. 2005....
- History and current concepts in the analysis of facial attractivenessMounir Bashour
University of Toronto, Ontario, Canada
Plast Reconstr Surg 118:741-56. 2006....
- Coadaptation of Helicobacter pylori and humans: ancient history, modern implicationsJohn C Atherton
Nottingham Digestive Diseases Centre Biomedical Research Unit and Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom
J Clin Invest 119:2475-87. 2009..These may have contributed to recent increases in esophageal adenocarcinoma and, more speculatively, other modern diseases...
- The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspectiveO Semino
Dipartimento di Genetica e Microbiologia, Universita di Pavia, Via Ferrata 1, 27100 Pavia, Italy
Science 290:1155-9. 2000....
- Comparison of maternal lineage and biogeographic analyses of ancient and modern Hungarian populationsGyöngyvér Tömöry
Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, 6726 Szeged, Hungary
Am J Phys Anthropol 134:354-68. 2007..Modern Hungarian-speaking populations seem to be specifically European. Our findings demonstrate that significant genetic differences exist between the ancient and recent Hungarian-speaking populations, and no genetic continuity is seen...
- Early domesticated fig in the Jordan ValleyMordechai E Kislev
Faculty of Life Sciences, Bar Ilan University, 52900 Ramat Gan, Israel
Science 312:1372-4. 2006..Hence, fig trees could have been the first domesticated plant of the Neolithic Revolution, which preceded cereal domestication by about a thousand years...
- Yersinia pestis--etiologic agent of plagueR D Perry
Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA
Clin Microbiol Rev 10:35-66. 1997..These areas of research have provide new insights into the host-parasite relationship. This review will update our present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague...
- Detection and molecular characterization of 9,000-year-old Mycobacterium tuberculosis from a Neolithic settlement in the Eastern MediterraneanIsrael Hershkovitz
Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
PLoS ONE 3:e3426. 2008..tuberculosis genomic analysis. Direct examination of ancient human remains for M. tuberculosis biomarkers should aid our understanding of the nature of prehistoric tuberculosis and the host/pathogen relationship...
- Unravelling migrations in the steppe: mitochondrial DNA sequences from ancient central AsiansC Lalueza-Fox
Unitat d Antropologia, Departimenti Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Avinguda Diagonal 645, 08028 Barcelona, Spain
Proc Biol Sci 271:941-7. 2004..This study demonstrates the usefulness of the ancient DNA in unravelling complex patterns of past human migrations so as to help decipher the origin of present-day admixed populations...
- Cacao usage by the earliest Maya civilizationW Jeffrey Hurst
Hershey Foods Technical Center, PO Box 805, Hershey, Pennsylvania 17033, USA
Nature 418:289-90. 2002..Our application of this new and highly sensitive analytical technique could be extended to the identification of other ancient foods and beverages...
- The origins of AfroasiaticChristopher Ehret
Science 306:1680; author reply 1680. 2004
- Genetic variation in prehistoric SardiniaDavid Caramelli
Dipartimento di Biologia Animale e Genetica, Laboratorio di Antropologia, Universita di Firenze, Firenze, Italy
Hum Genet 122:327-36. 2007....
- Starch fossils and the domestication and dispersal of chili peppers (Capsicum spp. L.) in the AmericasLinda Perry
Archaeobiology Program, Department of Anthropology, Smithsonian National Museum of Natural History, Post Office Box 37012, Washington, DC 20013 7012, USA
Science 315:986-8. 2007..The starch grain assemblages demonstrate that maize and chilies occurred together as an ancient and widespread Neotropical plant food complex that predates pottery in some regions...
- Evolution, consequences and future of plant and animal domesticationJared Diamond
Department of Physiology, University of California Medical School, Los Angeles, 90095 1751, USA
Nature 418:700-7. 2002....
- On the origin of leprosyMarc Monot
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, Paris, France
Science 308:1040-2. 2005..The disease seems to have originated in Eastern Africa or the Near East and spread with successive human migrations. Europeans or North Africans introduced leprosy into West Africa and the Americas within the past 500 years...
- Paleoparasitology of Chagas disease revaled by infected tissues from Chilean mummiesL F Ferreira
Fundacao Oswaldo Cruz, Escola Nacional de Saude Publica, Rio de Janeiro, Brazil
Acta Trop 75:79-84. 2000..cruzi specific molecular probe. The origin and dispersion of T. cruzi human infection is discussed as well as the molecular paleoparasitological approach, and what it may represent in an evolutionary perspective...
- Single, rapid coastal settlement of Asia revealed by analysis of complete mitochondrial genomesVincent Macaulay
Department of Statistics, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
Science 308:1034-6. 2005..There was an early offshoot, leading ultimately to the settlement of the Near East and Europe, but the main dispersal from India to Australia approximately 65,000 years ago was rapid, most likely taking only a few thousand years...
- Dental microwear texture analysis shows within-species diet variability in fossil homininsRobert S Scott
1 Department of Anthropology, University of Arkansas, Fayetteville, Arkansas 72701, USA 2 These authors contributed equally to this work
Nature 436:693-5. 2005..africanus. This suggests that A. africanus ate more tough foods and P. robustus consumed more hard and brittle items, but that both had variable and overlapping diets...
- Genetic analysis of the skeletal remains attributed to Francesco PetrarcaDavid Caramelli
Dipartimento di Biologia Animale e Genetica, Laboratorio di Antropologia, Universita di Firenze, Via del Proconsolo 12, 50122 Firenze, Italy
Forensic Sci Int 173:36-40. 2007..These results are consistent with morphological investigations and confirm the importance of integrating molecular and morphological approaches in investigating historical remains...
- Molecular analysis of skeletal tuberculosis in an ancient Egyptian populationA Zink
Department of Pathology, , , Germany
J Med Microbiol 50:355-66. 2001..tuberculosis was relatively frequent in ancient Egypt...
- DNA sequences from multiple amplifications reveal artifacts induced by cytosine deamination in ancient DNAM Hofreiter
Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D-04103 Leipzig, Germany
Nucleic Acids Res 29:4793-9. 2001..1% even under the unlikely scenario where each amplification starts from a single template molecule...
- Farmers and their languages: the first expansionsJared Diamond
Department of Geography, University of California, Los Angeles, CA 90095 1524, USA
Science 300:597-603. 2003..Further progress will depend on interdisciplinary research that combines archaeology, crop and livestock studies, physical anthropology, genetics, and linguistics...
- First Homo erectus from Turkey and implications for migrations into temperate EurasiaJohn Kappelman
Department of Anthropology, The University of Texas, Austin, TX 78712 0303, USA
Am J Phys Anthropol 135:110-6. 2008..Evidence for TB in the new specimen supports the thesis that reduced UVR was one of the many climatic variables presenting an adaptive challenge to ancient hominins during their migration into the temperate regions of Europe and Asia...
- A three-stage colonization model for the peopling of the AmericasAndrew Kitchen
Department of Anthropology, University of Florida, Gainesville, Florida, USA
PLoS ONE 3:e1596. 2008..Specifically, we analyze mitochondrial and nuclear genetic data by using complementary coalescent models of demographic history and incorporating non-genetic data to enhance the anthropological relevance of the analysis...
- Genotypic analysis of the earliest known prehistoric case of tuberculosis in BritainG Michael Taylor
Department of Infectious Diseases and Microbiology, CMMI, Imperial College of Science, Flowers Building, Armstrong Road, London SW7 2AZ, United Kingdom
J Clin Microbiol 43:2236-40. 2005..tuberculosis isolates. All evidence obtained was consistent with surviving mycobacterial DNA being highly fragmented in this case...
- Going east: new genetic and archaeological perspectives on the modern human colonization of EurasiaPaul Mellars
Department of Archaeology, Cambridge University, Cambridge CB2 3DZ, UK
Science 313:796-800. 2006....
- Paleo-Eskimo mtDNA genome reveals matrilineal discontinuity in GreenlandM Thomas P Gilbert
Center for Ancient Genetics, Department of Biology, Universitetsparken 15, DK 2100 Copenhagen, Denmark
Science 320:1787-9. 2008..This result suggests that the earliest migrants into the New World's northern extremes derived from populations in the Bering Sea area and were not directly related to Native Americans or the later Neo-Eskimos that replaced them...
- The molecular genetics of crop domesticationJohn F Doebley
Department of Genetics, University of Wisconsin, Madison, WI 53706, USA
Cell 127:1309-21. 2006....
- The late Pleistocene dispersal of modern humans in the AmericasTed Goebel
Center for the Study of the First Americans, Department of Anthropology, Texas A and M University, 4352 TAMU, College Station, TX 77843 4352, USA
Science 319:1497-502. 2008..If this is the time of colonization, geological data from western Canada suggest that humans dispersed along the recently deglaciated Pacific coastline...
- Climate-driven ecosystem succession in the Sahara: the past 6000 yearsS Kröpelin
Africa Research Unit, Institute of Prehistoric Archaeology, University of Cologne, Jennerstrasse 8, D 50823 Köln, Germany
Science 320:765-8. 2008..P. This gradual rather than abrupt termination of the African Humid Period in the eastern Sahara suggests a relatively weak biogeophysical feedback on climate...
- Climate-controlled Holocene occupation in the Sahara: motor of Africa's evolutionRudolph Kuper
Collaborative Research Center 389 ACACIA, University of Cologne, Institute of Prehistoric Archaeology, Africa Research Unit, Jennerstrasse 8, 50823 Köln, Germany
Science 313:803-7. 2006..C.E. Southward shifting of the desert margin helped trigger the emergence of pharaonic civilization along the Nile, influenced the spread of pastoralism throughout the continent, and affects sub-Saharan Africa to the present day...
- Why did modern human populations disperse from Africa ca. 60,000 years ago? A new modelPaul Mellars
Department of Archaeology, Cambridge University, Downing Street, Cambridge CB2 3DZ, England
Proc Natl Acad Sci U S A 103:9381-6. 2006....
- How Neanderthal molar teeth grewRoberto Macchiarelli
Laboratoire de Géobiologie, Biochronologie et Paléontologie humaine, UMR 6046 CNRS, Universite de Poitiers, 86022 Poitiers, France
Nature 444:748-51. 2006..These data are the first on internal molar microstructure; they firmly place key Neanderthal life history variables within those known for modern humans...
- Whole-genome shotgun sequencing of mitochondria from ancient hair shaftsM Thomas P Gilbert
Centre for Ancient Genetics, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
Science 317:1927-30. 2007..The method therefore sets the stage for molecular-genetic analysis of museum collections...
- Ancient DNA provides new insights into the history of south Siberian Kurgan peopleChristine Keyser
Laboratoire d Anthropologie Moléculaire, Institut de Medecine Legale, Universite de Strasbourg, 11 rue Humann, 67085, Strasbourg Cedex, France
Hum Genet 126:395-410. 2009..To the best of our knowledge, no equivalent molecular analysis has been undertaken so far...
- Genotyping, Orientalis-like Yersinia pestis, and plague pandemicsMichel Drancourt
Universite de la Mediterranee, Marseille, France
Emerg Infect Dis 10:1585-92. 2004..pestis Orientalis. These data indicate that Y. pestis caused cases of Justinian plague. The two historical plague pandemics were likely caused by Orientalis-like strains...
- Microfossil evidence for pre-Columbian maize dispersals in the neotropics from San Andres, Tabasco, MexicoMary E D Pohl
Department of Anthropology, Florida State University, Tallahassee, FL 32306, USA
Proc Natl Acad Sci U S A 104:6870-5. 2007..Multiple data sets from many sites indicate that maize was brought under cultivation and domesticated and had spread rapidly out of its domestication cradle in tropical southwest Mexico by the eighth millennium before the present...
- Preceramic adoption of peanut, squash, and cotton in northern PeruTom D Dillehay
Department of Anthropology, Vanderbilt University, Nashville, TN 37221, USA
Science 316:1890-3. 2007..These data provide evidence for early use of peanut and squash in the human diet and of cotton for industrial purposes and indicate that horticultural economies in parts of the Andes took root by about 10,000 years ago...
- Mosaics of ancient mitochondrial DNA: positive indicators of nonauthenticityHans Jurgen Bandelt
Fachbereich Mathematik, Universitat Hamburg, Hamburg, Germany
Eur J Hum Genet 13:1106-12. 2005..To reject or question authenticity of particular sequencing results a posteriori, one can follow similar strategies of focused database comparisons that have proven to be effective and successful in the case of flawed modern mtDNA data...
- Cattle domestication in the Near East was followed by hybridization with aurochs bulls in EuropeAnders Götherström
Evolutionary Biology Centre, Uppsala University, Department of Evolutionary Biology, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
Proc Biol Sci 272:2345-50. 2005..Rather than originating from a few geographical areas only, as indicated by mtDNA, our data suggest that the origin of domestic cattle may be far more complex than previously thought...
- Characterization of Mycobacterium tuberculosis complex DNAs from Egyptian mummies by spoligotypingAlbert R Zink
Division of Palaeopathology, Institute of Pathology, Academic Teaching Hospital München Bogenhausen, D 81925 Munich, Germany
J Clin Microbiol 41:359-67. 2003..In addition, our results do not support the theory that M. tuberculosis originated from the M. bovis type but, rather, suggest that human M. tuberculosis may have originated from a precursor complex probably related to M. africanum...
- Alexander the Great, seafaring, and the spread of leprosySamuel Mark
Texas A and M University at Galvestion, USA
J Hist Med Allied Sci 57:285-311. 2002
- Mitochondrial DNA analysis shows a Near Eastern Neolithic origin for domestic cattle and no indication of domestication of European aurochsCeiridwen J Edwards
Smurfit Institute of Genetics, Trinity College, Dublin 2, Ireland
Proc Biol Sci 274:1377-85. 2007..During the period of coexistence, it appears that domestic cattle were kept separate from wild aurochs and introgression was extremely rare...
- Contrasting patterns in crop domestication and domestication rates: recent archaeobotanical insights from the Old WorldDorian Q Fuller
Institute of Archaeology, University College London, 31 34 Gordon Square, London WC1H 0PY, UK
Ann Bot 100:903-24. 2007..These traits include features that have been selected under the conditions of cultivation. From archaeological remains the easiest traits to study are seed size and in cereal crops the loss of natural seed dispersal...
- Stratigraphic placement and age of modern humans from Kibish, EthiopiaIan McDougall
Research School of Earth Sciences, Australian National University, Canberra, ACT 0200, Australia
Nature 433:733-6. 2005..Our preferred estimate of the age of the Kibish hominids is 195 +/- 5 kyr, making them the earliest well-dated anatomically modern humans yet described...
- Alexander the Great and West Nile virus encephalitisJohn S Marr
Virginia Department of Health, Richmond, VA, USA
Emerg Infect Dis 9:1599-603. 2003..We posit that Alexander may have died of West Nile virus encephalitis...
- Redefining the age of Clovis: implications for the peopling of the AmericasMichael R Waters
Departments of Anthropology and Geography, Center for the Study of the First Americans, Texas A and M University, 4352 TAMU, College Station, TX 77843 4352, USA
Science 315:1122-6. 2007..The revised age range for Clovis overlaps non-Clovis sites in North and South America. This and other evidence imply that humans already lived in the Americas before Clovis...
- Tuberculosis: from prehistory to Robert Koch, as revealed by ancient DNAHelen D Donoghue
Centre for Infectious Diseases and International Health, University College London, London, UK
Lancet Infect Dis 4:584-92. 2004..This has provided direct support for the current theory of Mycobacterium tuberculosis evolution, and suggests areas of investigation for the interaction of M tuberculosis with its host...
- Mitochondrial DNA and Y chromosome diversity and the peopling of the Americas: evolutionary and demographic evidenceTheodore G Schurr
Department of Anthropology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Am J Hum Biol 16:420-39. 2004..Finally, populations that formerly inhabited Beringia expanded into northern North America after the LGM, and gave rise to Eskimo-Aleuts and Na-Dené Indians...
- Population affinities of Neolithic Siberians: a snapshot from prehistoric Lake BaikalK P Mooder
Human Identification Laboratory for Archaeology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2G3, Canada
Am J Phys Anthropol 129:349-61. 2006..These results suggest that the Lake Baikal region experienced a significant depopulation event during the sixth millennium BP, and was reoccupied by a new immigrant population some 800 years later...
- Genetic analysis of early holocene skeletal remains from Alaska and its implications for the settlement of the AmericasBrian M Kemp
Department of Anthropology, Vanderbilt University, Nashville, TN 37235 7703, USA
Am J Phys Anthropol 132:605-21. 2007..In addition, this individual's Y-chromosome belongs to haplogroup Q-M3*, placing a minimum date of 10,300 years ago for the emergence of this haplogroup...
- How fast was wild wheat domesticated?Ken Ichi Tanno
Research Institute for Humanity and Nature, Takashima 335, Kamigyo, 602 0878 Kyoto, Japan
Science 311:1886. 2006..Slow domestication implies that after cultivation began, wild cereals may have remained unchanged for a long period, supporting claims that agriculture originated in the Near East approximately 10,500 years before the present...
- Anthropology. Autonomous cultivation before domesticationEhud Weiss
Martin Szusz Department of Land of Israel Studies and Archaeology and Faculty of Life Sciences, Bar Ilan University, 52900 Ramat Gan, Israel
Science 312:1608-10. 2006
- Tracking down human contamination in ancient human teethMaria Lourdes Sampietro
Unitat de Biologia Evolutiva, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
Mol Biol Evol 23:1801-7. 2006..We argue therefore that the typing of those involved in the manipulation of the ancient human specimens is critical in order to ensure that generated results are accurate...
- The last Viking King: a royal maternity case solved by ancient DNA analysisJørgen Dissing
Research Laboratory, Institute of Forensic Medicine, University of Copenhagen, Frederik V Vej 11, DK 2100 Copenhagen, Denmark
Forensic Sci Int 166:21-7. 2007..Although the entombed woman cannot be the Estrid, she may well be one of Sven's two daughters-in-law who were also called Estrid and who both became queens...
- The tempo of avian diversification: a comment on Johnson and CiceroRobert M Zink
Bell Museum, University of Minnesota, St Paul, Minnesota 55108, USA
Evolution 60:411-2; discussion 413-4. 2006..Therefore, our analysis of Johnson and Cicero's data suggests that the late Pleistocene was no more important for avian speciation than any other time during this time period...
- Weak climatic control of stand-scale fire history during the late holoceneDaniel G Gavin
Department of Plant Biology, University of Illinois, Urbana, Illinois 61801, USA
Ecology 87:1722-32. 2006....
- Sequencing and analysis of Neanderthal genomic DNAJames P Noonan
U S Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
Science 314:1113-8. 2006..This initial analysis of the Neanderthal genome advances our understanding of the evolutionary relationship of Homo sapiens and Homo neanderthalensis and signifies the dawn of Neanderthal genomics...
- Leprosy and tuberculosis in Iron Age Southeast Asia?N Tayles
Department of Anatomy and Structural Biology, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand
Am J Phys Anthropol 125:239-56. 2004....
- Evolution. Did early humans go north or south?Peter Forster
McDonald Institute for Archaeological Research, University of Cambridge, Cambridge CB2 3ER, UK
Science 308:965-6. 2005
- First report of Mycobacterium bovis DNA in human remains from the Iron AgeG Michael Taylor
Centre for Molecular Microbiology and Infectious Diseases, Imperial College of Science, Technology and Medicine, London, UK
Microbiology 153:1243-9. 2007..Moreover, it shows that loss of DNA from RD4, which defines classic M. bovis, had already occurred from the genome over 2000 years before the present...
- Ancient DNA-typing approaches for the determination of kinship in a disturbed collective burial siteT Schultes
Institute of Zoology and Anthropology, University of Gottingen
Anthropol Anz 58:37-44. 2000..In a bronze age collective site, the typing methods were tested for applicability to ancient DNA. For each approach, results were obtained, leading to the conclusion that the determination of kinship is achievable...
- Y-SNPs do not indicate hybridisation between European aurochs and domestic cattleRuth Bollongino
Palaeogenetics Group, Institute of Anthropology, Johannes Gutenberg University Mainz, Mainz, Germany
PLoS ONE 3:e3418. 2008..To test their hypothesis, we applied these Y-markers on Neolithic bone specimens from various European archaeological sites...
- Starch grains reveal early root crop horticulture in the Panamanian tropical forestD R Piperno
Smithsonian Tropical Research Institute, Ancon, Balboa, Republic of Panama
Nature 407:894-7. 2000..The data provide the earliest direct evidence for root crop cultivation in the Americas, and support an ancient and independent emergence of plant domestication in the lowland Neotropical forest...
- Ancient DNA from the first European farmers in 7500-year-old Neolithic sitesWolfgang Haak
Institut für Anthropologie, Johannes Gutenberg Universitat Mainz, Saarstrasse 21, D 55099 Mainz, Germany
Science 310:1016-8. 2005..2%) of this mtDNA type, revealing that these first Neolithic farmers did not have a strong genetic influence on modern European female lineages. Our finding lends weight to a proposed Paleolithic ancestry for modern Europeans...
- Mitochondrial genome diversity of Native Americans supports a single early entry of founder populations into AmericaWilson A Silva
Center for Cell Therapy and Regional Blood Center, University of Sao Paulo, Ribeirao Preto, Brazil
Am J Hum Genet 71:187-92. 2002....
- Mycobacterium tuberculosis complex DNA from an extinct bison dated 17,000 years before the presentB M Rothschild
Arthritis Center of Northeast Ohio, 5500 Market St, Youngstown, OH 44512, USA
Clin Infect Dis 33:305-11. 2001..Extensive precautions against contamination with modern M. tuberculosis complex DNA were employed, including analysis of paleontologic and modern specimens in 2 geographically separate laboratories...
- Patterns of damage in genomic DNA sequences from a NeandertalAdrian W Briggs
Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
Proc Natl Acad Sci U S A 104:14616-21. 2007..The results suggest that reliable genome sequences can be obtained from Pleistocene organisms...
- Inca expansion and parasitism in the lluta valley: preliminary dataCalogero Santoro
Museo Arqueológico San Miguel de Azapa, Universidad de Tarapaca, Arica, Chile
Mem Inst Oswaldo Cruz 98:161-3. 2003..Changes in parasite prevalence are described. It can be seen that the change in life imposed on the inhabitants of the Lluta Valley by the Incas caused an increase in parasitism...
- Nuclear and mitochondrial DNA analysis of a 2,000-year-old necropolis in the Egyin Gol Valley of MongoliaChristine Keyser-Tracqui
Laboratoire d Anthropologie Moléculaire, Institut de Medecine Legale, Strasbourg, France
Am J Hum Genet 73:247-60. 2003..To the best of our knowledge, this is the first study using biparental, paternal, and maternal genetic systems to reconstruct partial genealogies in a protohistoric necropolis...
- Tracing the genetic history of the Chinese people: mitochondrial DNA analysis of aneolithic population from the Lajia siteShi Zhu Gao
Laboratory of Ancient DNA, Research Center for Chinese Frontier Archaeology of Jilin University, Changchun 130012, China
Am J Phys Anthropol 133:1128-36. 2007..This study, combined with archaeological and anthropological investigations, provides a better understanding of the genetic history of the Chinese people...
- A 9,000-year record of Chagas' diseaseArthur C Aufderheide
Paleobiology Laboratory, Department of Pathology, University of Minnesota, Duluth School of Medicine, Duluth, MN 55812, USA
Proc Natl Acad Sci U S A 101:2034-9. 2004....
- Genomic sequencing of Pleistocene cave bearsJames P Noonan
United States Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA
Science 309:597-9. 2005..Comparison of cave bear and modern bear sequences revealed the evolutionary relationship of these lineages. The metagenomic approach used here establishes the feasibility of ancient DNA genome sequencing programs...
- Africa's wild C4 plant foods and possible early hominid dietsCharles R Peters
Anthropology Department and Institute of Ecology, Baldwin Hall, University of Georgia, Athens, Georgia 30602 1619, USA
J Hum Evol 48:219-36. 2005..CAM plants may have a more ancient history, but offer few opportunities for an additional C4-like dietary signal...
- Health of infants in an Imperial Roman skeletal sample: perspective from dental microstructureCharles Fitzgerald
Department of Anthropology, McMaster University, Hamilton, Ontario L8S 4L9, Canada
Am J Phys Anthropol 130:179-89. 2006..These results are discussed in light of historical records of Roman childhood rearing practices...
- Frequency of pathology in a large natural sample from Natural Trap Cave with special remarks on erosive disease in the PleistoceneB M Rothschild
The Arthritis Center of Northeast Ohio, Youngstown, OH 44512, USA
Reumatismo 55:58-65. 2003..Tooth breakage due to errors in bone manipulation was a problem for carnivores and one lion, Pantera atrox, was apparently reduced by joint disease to a scavenging lifestyle...
- Co-infection of Mycobacterium tuberculosis and Mycobacterium leprae in human archaeological samples: a possible explanation for the historical decline of leprosyHelen D Donoghue
Centre for Infectious Diseases and International Health, Department of Infection, University College London, 46 Cleveland Street, London W1T 4JF, UK
Proc Biol Sci 272:389-94. 2005....
- Drug addiction. Part I. Psychoactive substances in the past and presenceJ Vetulani
Institute of Pharmacology, Polish Academy of Sciences,
Pol J Pharmacol 53:201-14. 2001..The substance abuse approaches the level of global epidemics, and the recent usage of drugs of addition is also reviewed...
- Palaeolithic paintings. Evolution of prehistoric cave artH Valladas
Laboratoire des Sciences du Climat et de l Environnement, UMR CEA CNRS 1572, 91198 Gif sur Yvette Cedex, France
Nature 413:479. 2001..Prehistorians, who have traditionally interpreted the evolution of prehistoric art as a steady progression from simple to more complex representations, may have to reconsider existing theories of the origins of art...
- Anthropological and palaeopathological analysis of the human remains from three "Tombs of the Nobles" of the necropolis of Thebes-west, upper EgyptA Nerlich
Institute of Pathology, Ludwig Maximilians Universitat Munchen
Anthropol Anz 58:321-43. 2000..This is somewhat in contrast to the usually assumed high standard of living of the socially higher population of the capital of ancient Egypt...
- Plant science. Unfallen grains: how ancient farmers turned weeds into cropsJohn Doebley
Laboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA
Science 312:1318-9. 2006
- Breastfeeding--was a life line in the past and still is!Yngve Hofvander
Department of Women s and Children s Health, Uppsala University, Sweden
Ups J Med Sci 111:17-25. 2006
- Old-growth forests as global carbon sinksSebastiaan Luyssaert
Department of Biology, University of Antwerp, 2610 Wilrijk, Belgium
Nature 455:213-5. 2008..Old-growth forests accumulate carbon for centuries and contain large quantities of it. We expect, however, that much of this carbon, even soil carbon, will move back to the atmosphere if these forests are disturbed...
- [Brain, mind and symptoms]E García-Albea Ristol
Seccion de Neurologia, Universidad de Alcala, Hospital Principe de Asturias, Alcala de Henares, Madrid, Spain
Rev Neurol 42:439-43. 2006....
- Bacillus (corynebacterium) xerosis and the ocular surfaceJuan Murube
University of Alcala Madrid, Spain
Ocul Surf 4:6-9. 2006
- Embracing bioethics in neonatal intensive care, part I: evolving toward neonatal evidence-based ethicsIsabell B Purdy
NICU Clinical Research and HRI Follow Up, David Geffen School of Medicine, UCLA, Division of Neonatology and Developmental Biology, Los Angeles, CA 90095 1752, USA
Neonatal Netw 25:33-42. 2006..It also includes recommendations for enhancing the skills of neonatal nurses as patient advocates in NICU ethical issues, an area that is, at times, controversial and baffling to clinicians...
- Hemodynamic profiles of heart failure patients and "elementary qualities" of pre-hippocratic medicine: a hypothesis for a linguistic and epistemological relationshipGian Franco Gensini
Med Hypotheses 66:1246-8. 2006
- Nutrition and fitness from the first Olympiad in 776 BC to the 21st century and the concept of positive healthArtemis P Simopoulos
The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
World Rev Nutr Diet 98:1-22. 2008
- A 2,000-year record of mercury and ancient civilizations in seal hairs from King George Island, West AntarcticaLiguang Sun
Institute of Polar Environment, University of Science and Technology of China, Hefei, Anhui 230026, PR China
Sci Total Environ 368:236-47. 2006....
- A comparison of antimony and lead profiles over the past 2500 years in Flanders Moss ombrotrophic peat bog, ScotlandJoanna M Cloy
School of Geosciences, The University of Edinburgh, West Mains Road, Edinburgh, UKEH9 3JJ
J Environ Monit 7:1137-47. 2005....
- Lithogenic, oceanic and anthropogenic sources of atmospheric Sb to a maritime blanket bog, Myrarnar, Faroe IslandsWilliam Shotyk
Institute of Environmental Geochemistry, University of Heidelberg, INF 236, D 69120, Heidelberg, Germany
J Environ Monit 7:1148-54. 2005....
- The history of anatomy in PersiaMohammadali M Shoja
Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
J Anat 210:359-78. 2007..Knowledge of anatomy for this region in the 20th century was greatly influenced by Europe and America...
- Comment on Martínez-García et al. "Heavy metals in human bones in different historical epochs"Andrew Millard
Sci Total Environ 354:295-7; author reply 298-302. 2006..Lifetime heavy metal exposure cannot be deduced from diagenetically altered concentrations...
- Implications of biosimilars for the futurePhilip E Johnson
H Lee Moffitt Cancer Center, 12902 Magnolia Dr, Tampa, FL 33612 9497, USA
Am J Health Syst Pharm 65:S16-22. 2008....
- Traditional Korean medicine: now and the futureKang Hyun Leem
College of Korean Medicine, Semyung University, Jechon 390 711, Korea
Neurol Res 29:S3-4. 2007..It has developed unique medical theories and methods to treat diseases including neurological disorders such as stroke, epilepsy and Parkinson's disease...
- Male circumcision through the ages: the role of traditionNicola Zampieri
Department of Surgical Sciences, Pediatric Surgical Unit, University of Verona, Verona, Italy
Acta Paediatr 97:1305-7. 2008..In this study, we examine the evolution of tradition concerning infant male circumcision, utilizing evidence from classical medical texts as well as information from literature, legal sources and art...
- Reading our lips: the history of lipstick regulation in Western seats of powerSarah E Schaffer
Food Drug Law J 62:165-225. 2007
- Numeric expression of aesthetics and beautyB S Atiyeh
Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon
Aesthetic Plast Surg 32:209-16; discussion 217-9. 2008....
- Global climate change, war, and population decline in recent human historyDavid D Zhang
Department of Geography, University of Hong Kong, Pokfulam Road, Hong Kong
Proc Natl Acad Sci U S A 104:19214-9. 2007..Findings of this research may lend an additional dimension to the classic concepts of Malthusianism and Darwinism...
- [Origin and evolution of the terms "german" and "German" (II)]D P Mertz
Versicherungsmedizin 59:146-9. 2007
- TOLL RECEPTORS AND CONTROL OF MAMMALIAN IMMUNITYRuslan Medzhitov; Fiscal Year: 2005..Our ultimate goal is to understand whether activation of different TLRs results in the induction of distinct cellular and immune responses. ..
- Medicinal Plants of Antiquity: A Computerized DatabaseAlain Touwaide; Fiscal Year: 2007..These secondary databases will be linked to the primary database so that users of the primary database can consult at any moment the necessary information for a better understanding of ancient texts. [unreadable] [unreadable]..
- DETERMINANTS OF VISUAL PERCEPTIONLEON FESTINGER; Fiscal Year: 1980..see how information about the evolutionary, cultural and social history of humans, as inferred from paleontology, archaeology, ancient history and anthropology, can help us to create a theoretical, large context about human psychology.
- Genetics of Variation for Complex TraitsJohn Doebley; Fiscal Year: 2007..5) Finally, we will analyze the patterning of genetic diversity in genomic regions that have experienced recent and strong selective sweeps to understand how the genome responds to past selective pressure. ..
- Columbia-GHI Consortium for Claims-Based Cancer StudiesSTEVEN STELLMAN; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Palliative Care Curriculum for 3rd-Year Medical StudentsCharles von Gunten; Fiscal Year: 2007..Data will be compared with residents who have not been through the course as well as with residents and faculty participating in another study of education. ..
- Latino Eye Health: A Communication Strategy for DiabetesSheila West; Fiscal Year: 2007..Improvements in eye care seeking behaviors should help in avoiding visual loss from diabetic retinopathy and macula edema, the leading causes of visual loss in the working age Latino population. [unreadable] [unreadable]..
- Vitamin D insufficiency: Prevalence and Impact in Young School Age ChildrenKumaravel Rajakumar; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Neuromodulatory Effects of Ginkgolides and BilobalideKoji Nakanishi; Fiscal Year: 2007..These studies can potentially provide new targets for terpene trilactones in the central nervous system that require the synthesis of new ginkgolide and bilobalide ligands. [unreadable] [unreadable]..
- Interstitial Cystitis Clinical Research Network (ICCRN)J Nickel; Fiscal Year: 2007..site with Dr. Nickel as PI has the experience, expertise and the proven ability to design, implement and enroll patients with IC in clinical strudies and will be a valuable partner in the proposed ICCRN and UCPPSCG. ..
- TLR4 as an LPS sendor and susceptibility locusBruce Beutler; Fiscal Year: 2007..The new mutations that are found--and those that have already been found in preliminary efforts--will be isolated by positional cloning. ..
- A Selective Approach to Metastatic Gene DiscoveryCarlos Barbas; Fiscal Year: 2006..The net result of this study should be an increased understanding of the cell biology of metastasis and the discovery of novel molecular targets for diagnostic, prognostic and therapeutic application. ..
- CENTER FOR RESEARCH IN OLDER PEOPLE WITH PSYCHOSESDilip Jeste; Fiscal Year: 2006....
- Cataract: Health Disparity for Older African-AmericansSheila West; Fiscal Year: 2006..These data will advance the goal of reducing health disparity in visual disability from cataract among older African Americans. ..
- Sublingual Buprenorphine for Chronic Pain in Patients at Risk for Drug AbuseAndrew Rosenblum; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- DVD Consent for Research in Older Schizophrenia PatientsDilip Jeste; Fiscal Year: 2008..The DVD-based consent is not intended to supplant, but rather to supplement, the researcher-participant in-person interaction involved in consent process. ..
- Integrated Parametric and Non-parametric Mapping for Genome-Wife Association DataGONCALO ROCHA ABECASIS; Fiscal Year: 2008..The resulting data, together with genotype data from at least two other genome-wide association scans, will allow us to evaluate and calibrate our methods for association mapping. [unreadable] [unreadable] [unreadable] [unreadable]..
- New Paradigms of Cerebral Palsy Etiology: A Comprehensive Case Control StudyNIGEL SEFTON PANETH; Fiscal Year: 2010..Maternal interviews and birth certificates will inform the above analyses by linking molecular information to self-reported and recorded clinical events and conditions. ..
- GENERAL CLINICAL RESEARCH CENTERKevin J Tracey; Fiscal Year: 2010..This proposal seeks continued funding for the Feinstein GCRC by NCRR. ..
- The Effect of Statins on Skeletal Muscle FunctionPAUL DAVIS THOMPSON; Fiscal Year: 2010....
- Transcriptional Blockades of HIV-1Carlos F Barbas; Fiscal Year: 2010..The new approach we develop will be applicable to other diseases. ..
- Computational and Statistical Models for Human PedigreesGONCALO ROCHA ABECASIS; Fiscal Year: 2008..abstract_text> ..
- Gene Mapping of Complex Traits Using Resequencing DataGONCALO ROCHA ABECASIS; Fiscal Year: 2010..Here, we propose to develop efficient methods for analyzing high-throughput sequence data and to distribute software tools that allow others to extract maximum benefit from our methods. ..
- Antepartum Interpersonal Psychotherapy at 3 NYC SitesMargaret Spinelli; Fiscal Year: 2009..Co-investigators are maternal fetal medicine faculty from respective sites who will be primary liaison to the respective departments of obstetrics and provide clinical obstetrical needs of the study. ..
- THE DETERMINANTS OF INFANT MORTALITY: STATISTICAL MODELSTIMOTHY GAGE; Fiscal Year: 2009..We will develop and make available programs for conducting Covariate Density Defined mixtures of GLMs. ..
- Academic Palliative CareCharles von Gunten; Fiscal Year: 2008..All reentered investigators are seeking NCI funding and have the potential to become independent investigators. ..
- Yearly Mass Treatment C. Trachomatis: When Can We Stop?Sheila West; Fiscal Year: 2008..unreadable] [unreadable]..
- Who drives safely? Visual/cognitive predictors in EldersSheila West; Fiscal Year: 2008..This study will provide critical data on the interactive role of vision, visual attention, and cognition in changing older persons driving behaviors, and the resulting effect on driver errors and risk of crashes. ..
- Mutagenic analysis of LPS responsesBruce Beutler; Fiscal Year: 2006..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection. ..
- Genetic Architecture of the Baboon Craniofacial ComplexRICHARD SHERWOOD; Fiscal Year: 2006..unreadable] [unreadable]..
- STUDIES OF NATURAL PRODUCTS BY CHIROPTICAL METHODSKoji Nakanishi; Fiscal Year: 2004..This will include CD studies of retinal/opsin in rhodopsin and retinal/bacterioopsin in bacteriorhodopsin. Vinca alkaloid/tubulin and taxoid/tubulin complexes will be analyzed by FDCD. ..
- A Mouse Model of Gaucher DiseaseErnest Beutler; Fiscal Year: 2005..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
- DEPRESSION, 5-HT1A RECEPTOR & NEUROPLASTICITYEfrain Azmitia; Fiscal Year: 2005..The applicant will focus on dendritic collapse and apoptosis of neurons. This work will continue our long-term research into the interactions between serotonin and adult neumplasticity. ..
- LATE ONSET SCHIZOPHRENIA--A NEUROPSYCHIATRIC STUDYDilip Jeste; Fiscal Year: 2002..g., MRI quantitative analysis, outcome and functioning measures) to the new questions being asked. Our studies should have a major impact on the understanding of schizophrenia and aging. ..
- Targeted Activation of Fetal HemoglobinCarlos Barbas; Fiscal Year: 2004..It is anticipated that the results of this work will provide a novel approach to study the molecular mechanisms of hemoglobinopathies as well as new strategies to treat them. ..
- Human Subjects Research Enhancements ProgramRichard Rivlin; Fiscal Year: 2003..The ongoing collaborations of IFCP and South Carolina will be greatly strengthened by the completion of upgrading procedures for protection of human subjects by funding the second year of support of this grant program. ..
- ENDOGENOUS GENE REGULATION FOR CANCER AND ANGIOGENESISCarlos Barbas; Fiscal Year: 2004..It is anticipated that the results of this work will provide researchers with novel tools to study the molecular mechanisms of disease as well as a new strategy to treat it. ..
- INTERVENTIONS FOR VISUAL LOSS IN NURSING HOME RESIDENTSSheila West; Fiscal Year: 2002..This trial will answer timely questions of the impact on the functional status of the most frail elderly of modest, potentially sustainable inputs into improving the appropriate utilization of eye care services. ..
- CHARACTERIZATION & TREATMENT OF CATEGORY III PROSTATITISJ Nickel; Fiscal Year: 2003..Results from this 3 part study will be analyzed and correlated between groups and within groups, both concurrently and sequentially. ..
- NEUROLEPTIC-INDUCED MOVEMENT DISORDERS IN OLDER PATIENTSDilip Jeste; Fiscal Year: 2003..We believe that our findings will have major therapeutic implications for the use of antipsychotics, particularly in older patients. ..
- AMD AND RISK FACTORS IN A HISPANIC POPULATIONSheila West; Fiscal Year: 2003..Such data will advance our understanding of the magnitude of AMD in this ethnic group, and the way in which risk factors relate to AMD in different populations. ..
- MENTAL HEALTH 5 HTIA RECEPTOR AND NEUROPLASTICITYEfrain Azmitia; Fiscal Year: 2005....
- Metabolism of Carcinogens and Drugs by Human P450sF Guengerich; Fiscal Year: 2005..Successful completion of these collective studies should provide better understanding of the ways in which human P450s catalyze oxidation of carcinogens and drugs and the significance of variations in these enzymes. ..
- Forward Genetic Analysis of the Innate Immune Contribution to MCMV ResistanceBruce Beutler; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Mechanisms for neurocognitive damage of HIV+ drug usersRaul Gonzalez; Fiscal Year: 2006..abstract_text> ..
- ENCODING IN SOMATIC SENSE ORGANSEDWARD PERL; Fiscal Year: 2001..N.S? This information, in an area which has been barely explored, could greatly improve our understanding of how mechanical events are sensed. This could open up new areas of inquiry of possible importance in sensory deficits. ..
- STUDIES ON RHODOPSIN & AGE-RELATED MACULAR DEGENERATIONKoji Nakanishi; Fiscal Year: 2006..abstract_text> ..
- Spontaneous Arousals in "CHIME" Infants at Risk for SIDSROBERT DARNALL; Fiscal Year: 2006..Finally, we will examine the relationships among the level of arousal, post-conceptional age, sleep state, and other infant behaviors such as feeding that are also associated with changes in autonomic activity. ..
- ANIMAL MODELS OF EXTREME HYPERPHAGIA AND HIGH METABOLISMJared Diamond; Fiscal Year: 2001....
- The Angiotensinogen Gene and Human HypertensionLynn Jorde; Fiscal Year: 2006..In summary, our extensive analysis of AGT variation in more than 1,600 subjects will clarify the role of this gene in essential hypertension and will test specific hypotheses about the evolution of AGT. ..
- EARLY EVENTS IN NEURAL AND HOMEOGENETIC INDUCTIONClaudio Stern; Fiscal Year: 2005..D. To explore the possible roles of 6 newly-identified candidate secreted factors in the early steps of neural induction and homeogenetic induction. ..
- FORMATION AND SURVIVAL OF RED BLOOD CELLSErnest Beutler; Fiscal Year: 2001..Should these point mutations fail to alter gene transcription, a search will be made for other potential mutations in linkage disequilibrium with the known -5,-8 and -24 polymorphisms, by sequencing upstream through the promotor. ..
- IN VITRO EVOLUTION OF HUMAN ANTIHIV ANTIBODIESCarlos Barbas; Fiscal Year: 2002....
- AGING AND DEMENTIA--LONGITUDINAL COURSE OF SUBGROUPSBarry Reisberg; Fiscal Year: 2002..Collectively, these cohorts include over 1300 persons. The comprehensive evaluations include behavioral, mental status, neuropsychologic, neurologic, neuroimaging, electrophysiologic, and postmortem studies. ..
- TRIAL OF ANTIBIOTICS TO REDUCE RECURRENT TRICHIASISSheila West; Fiscal Year: 2005..abstract_text> ..
- SPINAL AND PROJECTION MECHANISMS RELATED TO PAINEDWARD PERL; Fiscal Year: 2008..Immunocytochemical studies will be used to complement the structural and pharmacological analyses to aid in establishing mediators involved in linkages between SDH neurons. ..
- COOPERATIVE CORE LAB AND CLINICAL NUTRITION RESEARCHRichard Rivlin; Fiscal Year: 2006..abstract_text> ..
- Metabolic Effects of Newer Antipsychotics in Older PtsDilip Jeste; Fiscal Year: 2009..abstract_text> ..
- Evolution of BMP Genes 2 and 4 in ArchosaursCHRIS ORGAN; Fiscal Year: 2007..Aim three is to elucidate the evolution of bmp2 and bmp4 coding regions. This project will be the first large scale examination of non-avian reptile genome structure and evolution. ..
- Endothelial Cell in Progressive Renal DiseaseRichard Johnson; Fiscal Year: 2009..abstract_text> ..
- AASK Cohort StudyShaul Massry; Fiscal Year: 2007..Such results might eventually lead to new strategies that delay or prevent ESRD. ..
- Role of Inter-alpha Inhibitors in Anthrax IntoxicationSteven Opal; Fiscal Year: 2007..Our research is focused on the development of a new and safe treatment based on the ability of inter-alpha proteins to prevent the fatal consequences of anthrax infection. [unreadable] [unreadable] [unreadable] [unreadable]..