population

Summary

Summary: The total number of individuals inhabiting a particular region or area.

Top Publications

  1. pmc PLINK: a tool set for whole-genome association and population-based linkage analyses
    Shaun Purcell
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Hum Genet 81:559-75. 2007
  2. pmc Inference of population splits and mixtures from genome-wide allele frequency data
    Joseph K Pickrell
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 8:e1002967. 2012
  3. pmc The international limits and population at risk of Plasmodium vivax transmission in 2009
    Carlos A Guerra
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, UK
    PLoS Negl Trop Dis 4:e774. 2010
  4. pmc Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 113:192-200. 2005
  5. pmc Patterns of multimorbidity in the aged population. Results from the KORA-Age study
    Inge Kirchberger
    Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 7:e30556. 2012
  6. pmc Prevalence of diabetes and high risk for diabetes using A1C criteria in the U.S. population in 1988-2006
    Catherine C Cowie
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 33:562-8. 2010
  7. ncbi A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex
    David C Van Essen
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave, Box 8108, St Louis, MO 63110, USA
    Neuroimage 28:635-62. 2005
  8. pmc Interpreting principal component analyses of spatial population genetic variation
    John Novembre
    Department of Human Genetics, University of Chicago, 920 E 58th Street, CLSC 5th floor, Chicago, Illinois 60637, USA
    Nat Genet 40:646-9. 2008
  9. ncbi What is a population? An empirical evaluation of some genetic methods for identifying the number of gene pools and their degree of connectivity
    Robin S Waples
    Northwest Fisheries Science Center, Seattle, WA 98112 USA
    Mol Ecol 15:1419-39. 2006
  10. pmc Inference of population structure using dense haplotype data
    Daniel John Lawson
    Department of Mathematics, University of Bristol, Bristol, United Kingdom
    PLoS Genet 8:e1002453. 2012

Detail Information

Publications257 found, 100 shown here

  1. pmc PLINK: a tool set for whole-genome association and population-based linkage analyses
    Shaun Purcell
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Hum Genet 81:559-75. 2007
    ..We introduce PLINK and describe the five main domains of function: data management, summary statistics, population stratification, association analysis, and identity-by-descent estimation...
  2. pmc Inference of population splits and mixtures from genome-wide allele frequency data
    Joseph K Pickrell
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 8:e1002967. 2012
    ..In this paper, we present a statistical model for inferring the patterns of population splits and mixtures in multiple populations...
  3. pmc The international limits and population at risk of Plasmodium vivax transmission in 2009
    Carlos A Guerra
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, UK
    PLoS Negl Trop Dis 4:e774. 2010
    ..vivax malaria, together with estimates of the human population at risk (PAR) of any level of transmission in 2009.
  4. pmc Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 113:192-200. 2005
    ..Traditionally, this approach has been used in population groups without much diversity...
  5. pmc Patterns of multimorbidity in the aged population. Results from the KORA-Age study
    Inge Kirchberger
    Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 7:e30556. 2012
    ..The objective of the study was to explore patterns of comorbidity and multimorbidity in an elderly population using different analytical approaches...
  6. pmc Prevalence of diabetes and high risk for diabetes using A1C criteria in the U.S. population in 1988-2006
    Catherine C Cowie
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Diabetes Care 33:562-8. 2010
    ..CONCLUSIONS Although A1C detects much lower prevalences than glucose criteria, hyperglycemic conditions remain high in the U.S., and elderly and minority groups are disproportionately affected...
  7. ncbi A Population-Average, Landmark- and Surface-based (PALS) atlas of human cerebral cortex
    David C Van Essen
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave, Box 8108, St Louis, MO 63110, USA
    Neuroimage 28:635-62. 2005
    ..The Population-Average, Landmark- and Surface-based (PALS) atlas approach involves surface-based and volume-based ..
  8. pmc Interpreting principal component analyses of spatial population genetic variation
    John Novembre
    Department of Human Genetics, University of Chicago, 920 E 58th Street, CLSC 5th floor, Chicago, Illinois 60637, USA
    Nat Genet 40:646-9. 2008
    Nearly 30 years ago, Cavalli-Sforza et al. pioneered the use of principal component analysis (PCA) in population genetics and used PCA to produce maps summarizing human genetic variation across continental regions...
  9. ncbi What is a population? An empirical evaluation of some genetic methods for identifying the number of gene pools and their degree of connectivity
    Robin S Waples
    Northwest Fisheries Science Center, Seattle, WA 98112 USA
    Mol Ecol 15:1419-39. 2006
    We review commonly used population definitions under both the ecological paradigm (which emphasizes demographic cohesion) and the evolutionary paradigm (which emphasizes reproductive cohesion) and find that none are truly operational...
  10. pmc Inference of population structure using dense haplotype data
    Daniel John Lawson
    Department of Mathematics, University of Bristol, Bristol, United Kingdom
    PLoS Genet 8:e1002453. 2012
    ..We propose a novel inference framework that aims to efficiently capture information on population structure provided by patterns of haplotype similarity...
  11. pmc Savant Genome Browser 2: visualization and analysis for population-scale genomics
    Marc Fiume
    Department of Computer Science, University of Toronto, Ontario, Canada M5S 2E4
    Nucleic Acids Res 40:W615-21. 2012
    ..The Savant Genome Browser is freely available (open source) at www.savantbrowser.com...
  12. pmc Imputation of high-density genotypes in the Fleckvieh cattle population
    Hubert Pausch
    Lehrstuhl fuer Tierzucht, Technische Universitaet Muenchen, 85354, Freising, Germany
    Genet Sel Evol 45:3. 2013
    ..Imputation of genotypes makes it possible to extrapolate genotypes from lower to higher density arrays based on a representative reference sample for which genotypes are obtained at higher density...
  13. pmc Pre-vaccination nasopharyngeal pneumococcal carriage in a Nigerian population: epidemiology and population biology
    Ifedayo M O Adetifa
    Medical Research Council Unit, The Gambia, Fajara, The Gambia
    PLoS ONE 7:e30548. 2012
    ..This study was carried out to describe the pre vaccination epidemiology and population biology of pneumococcal carriage in Nigeria.
  14. pmc Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation
    Jeffrey M Kidd
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Hum Genet 91:660-71. 2012
    Full sequencing of individual human genomes has greatly expanded our understanding of human genetic variation and population history...
  15. pmc Local adaptation and vector-mediated population structure in Plasmodium vivax malaria
    Deirdre A Joy
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Mol Biol Evol 25:1245-52. 2008
    ..Adaptation to local vectors may play an important role in generating population structure in Plasmodium...
  16. pmc A generic estimation of population subdivision using distances between alleles with special reference for microsatellite loci
    Y Michalakis
    Laboratoire d Ecologie, Universite P and M Curie CNRS URA 258, Paris, France
    Genetics 142:1061-4. 1996
    Several estimators of population differentiation have been proposed in the recent past to deal with various types of genetic markers (i.e., allozymes, nucleotide sequences, restriction fragment length polymorphisms, or microsatellites)...
  17. pmc The global distribution and population at risk of malaria: past, present, and future
    Simon I Hay
    TALA Research Group, Department of Zoology, University of Oxford, Oxford, UK
    Lancet Infect Dis 4:327-36. 2004
    ..Contemporaneous population surfaces also allowed changes in the numbers of people living in areas of malaria risk to be quantified...
  18. pmc Improving the accuracy and efficiency of identity-by-descent detection in population data
    Brian L Browning
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Genetics 194:459-71. 2013
    ..To investigate the properties of Refined IBD, we simulate SNP data from a model with recent superexponential population growth that is designed to match United Kingdom data...
  19. pmc High-precision genetic mapping of behavioral traits in the diversity outbred mouse population
    R W Logan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Genes Brain Behav 12:424-37. 2013
    ..The newly developed Diversity Outbred (DO) population promises to deliver improved resolution that will circumvent costly fine-mapping studies...
  20. ncbi Risk factors for chronic kidney disease in a community-based population: a 10-year follow-up study
    K Yamagata
    Department of Nephrology, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Kidney Int 71:159-66. 2007
    ..of this study was to explore risk factors affecting the incidence of chronic kidney disease (CKD) in general population. We conducted a 10-year follow-up study with 123 764 (male: 41 012, female: 82 752) adults aged 40 years and ..
  21. pmc Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study
    Anne K Jenum
    Department of Endocrinology, Oslo University Hospital HF, Aker, PO Box 4959 Nydalen, N 0424 Oslo, Norway
    Eur J Endocrinol 166:317-24. 2012
    ..We compared prevalence rates, risk factors, and the effect of ethnicity using the World Health Organization (WHO) and modified IADPSG criteria...
  22. ncbi [Cardiovascular risk factors in Spain in the first decade of the 21st Century, a pooled analysis with individual data from 11 population-based studies: the DARIOS study]
    Maria Grau
    Grupo de Epidemiología y Genética Cardiovascular, Programa de Investigación en Procesos Inflamatorios y Cardiovasculares, Instituto Municipal de Investigacion Medica, Barcelona, Espana
    Rev Esp Cardiol 64:295-304. 2011
    ..To estimate the prevalence of cardiovascular risk factors in individuals aged 35-74 years in 10 of Spain's autonomous communities and determine the geographic variation of cardiovascular risk factors distribution...
  23. pmc Effects of Pleistocene glaciations and rivers on the population structure of Bornean orangutans (Pongo pygmaeus)
    Natasha Arora
    Anthropological Institute and Museum, University of Zurich, 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 107:21376-81. 2010
    ..We investigated the population structure and underlying mechanisms of an insular endemic, the Bornean orangutan (Pongo pygmaeus)...
  24. ncbi Analysis of the efficacy and toxicity of sorafenib in thyroid cancer: a phase II study in a UK based population
    Merina Ahmed
    Head and Neck Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK
    Eur J Endocrinol 165:315-22. 2011
    ..To evaluate the tolerability and efficacy of sorafenib in patients with thyroid carcinoma...
  25. pmc Population pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated malaria
    Joel Tarning
    Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Antimicrob Agents Chemother 56:1997-2007. 2012
    ..The objective of this study was to evaluate the population pharmacokinetic properties of piperaquine and dihydroartemisinin in pregnant and nonpregnant women with ..
  26. ncbi A pseudo-likelihood method for estimating effective population size from temporally spaced samples
    J Wang
    Institute of Zoology, Zoological Society of London, Regent s Park, London NW1 4RY, UK
    Genet Res 78:243-57. 2001
    A pseudo maximum likelihood method is proposed to estimate effective population size (Ne) using temporal changes in allele frequencies at multi-allelic loci...
  27. ncbi Insulin glargine use and short-term incidence of malignancies - a three-year population-based observation
    Rickard Ljung
    Swedish National Board of Health and Welfare, Stockholm, Sweden
    Acta Oncol 50:685-93. 2011
    ..To further investigate the association of cancer occurrence with the use of insulin glargine...
  28. pmc Effective population size and the efficacy of selection on the X chromosomes of two closely related Drosophila species
    Peter Andolfatto
    Department of Ecology and Evolutionary Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, USA
    Genome Biol Evol 3:114-28. 2011
    ..of new mutations, the importance of these evolutionary forces may differ in species with different effective population sizes...
  29. pmc The association between IGF-I and insulin resistance: a general population study in Danish adults
    Nele Friedrich
    Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
    Diabetes Care 35:768-73. 2012
    ..The aim of the current study was to evaluate the association between IGF-I level and insulin resistance in a Danish general population.
  30. ncbi Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: a pragmatic population-based 3-year intervention study
    Erik Roj Larsen
    Department of Orthopaedic Surgery, Randers Central Hospital, Randers, Denmark
    J Bone Miner Res 19:370-8. 2004
    ....
  31. pmc Measuring population transmission risk for HIV: an alternative metric of exposure risk in men who have sex with men (MSM) in the US
    Colleen F Kelley
    Department of Medicine, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e53284. 2012
    Various metrics for HIV burden and treatment success [e.g. HIV prevalence, community viral load (CVL), population viral load (PVL), percent of HIV-positive persons with undetectable viral load] have important public health limitations for ..
  32. pmc A genetic variant in pre-miR-27a is associated with a reduced renal cell cancer risk in a Chinese population
    Danni Shi
    State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China
    PLoS ONE 7:e46566. 2012
    ..The single nucleotide polymorphism (SNP) rs895819 is located at the terminal loop of pre-miR-27a. Here, we aimed to investigate whether SNP rs895819 was associated with the development of renal cell cancer (RCC) in a Chinese population.
  33. ncbi Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management
    Juan J Calvete
    Instituto de Biomedicina de Valencia, C S I C, Jaume Roig 11, 46010 Valencia, Spain
    J Proteomics 74:510-27. 2011
    ..Venoms from each of the 16 localities sampled contain both population-specific toxins and proteins shared by neighboring B. atrox populations...
  34. pmc Virulence-transmission trade-offs and population divergence in virulence in a naturally occurring butterfly parasite
    Jacobus C de Roode
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 105:7489-94. 2008
    ..These results show that selection on parasite transmission can explain why parasites harm their hosts, and suggest that constraints imposed by host ecology can lead to population divergence in parasite virulence.
  35. pmc High resolution population distribution maps for Southeast Asia in 2010 and 2015
    Andrea E Gaughan
    Department of Geography, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 8:e55882. 2013
    Spatially accurate, contemporary data on human population distributions are vitally important to many applied and theoretical researchers...
  36. ncbi Variation in surgical resection for lung cancer in relation to survival: population-based study in England 2004-2006
    Sharma P Riaz
    King s College London, Thames Cancer Registry, London, United Kingdom
    Eur J Cancer 48:54-60. 2012
    ..The use of surgical resection varies within England. We assessed the relationship between surgical resection rate and the survival of lung cancer patients in England...
  37. ncbi Prevalence and characteristics of opioid use in the US adult population
    Judith Parsells Kelly
    Slone Epidemiology Center of Boston University, 1010 Commonwealth Avenue, Boston, MA 02215, USA
    Pain 138:507-13. 2008
    This report describes the prevalence of opioid use in the US adult population, overall and in subgroups, the characteristics of opioid use, and concomitant medication use among opioid users...
  38. pmc A hierarchical Bayesian model for next-generation population genomics
    Zachariah Gompert
    Department of Botany and Program in Ecology, University of Wyoming, Laramie, Wyoming 82071, USA
    Genetics 187:903-17. 2011
    ..the genome and understanding the genomic consequences of these evolutionary processes is a fundamental aim of population genetics...
  39. pmc Anti-depressant medication use and C-reactive protein: results from two population-based studies
    Mark Hamer
    Department of Epidemiology and Public Health, University College London, London, UK
    Brain Behav Immun 25:168-73. 2011
    ..a marker of low grade systemic inflammation as a potential pathway linking anti-depressant use and CVD in two population based studies. Data were collected in a representative sample of 8131 community dwelling adults (aged 47.4±15...
  40. ncbi A population-based study on peanut, tree nut, fish, shellfish, and sesame allergy prevalence in Canada
    Moshe Ben-Shoshan
    Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Center, Montreal, Quebec, Canada
    J Allergy Clin Immunol 125:1327-35. 2010
    ..Recent studies suggest an increased prevalence of food-induced allergy and an increased incidence of food-related anaphylaxis. However, prevalence estimates of food allergies vary considerably between studies...
  41. ncbi Genetic variants in CYP (-1A2, -2C9, -2C19, -3A4 and -3A5), VKORC1 and ABCB1 genes in a black South African population: a window into diversity
    Collet Dandara
    School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, South Africa
    Pharmacogenomics 12:1663-70. 2011
    ..The aim of this study was to genotype pharmacogenetically relevant variants in black South Africans, to expand the limited data set available for indigenous African populations...
  42. ncbi Fat intake at midlife and risk of dementia and Alzheimer's disease: a population-based study
    M H Laitinen
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet, Stockholm, Sweden
    Dement Geriatr Cogn Disord 22:99-107. 2006
    ..Lifestyle and vascular factors have been linked to dementia and Alzheimer's disease (AD), but the role of dietary fats in the development of dementia is less clear...
  43. ncbi To GEE or not to GEE: comparing population average and mixed models for estimating the associations between neighborhood risk factors and health
    Alan E Hubbard
    Division of Biostatistics, Berkeley School of Public Health, University of California, Berkeley, CA 94720, USA
    Epidemiology 21:467-74. 2010
    ..Random effects models (or mixed models) use maximum likelihood estimation. Population average models typically use a generalized estimating equation (GEE) approach...
  44. ncbi High prevalence of the CYP2B6 516G-->T(*6) variant and effect on the population pharmacokinetics of efavirenz in HIV/AIDS outpatients in Zimbabwe
    Christopher Nyakutira
    Department of DMPK and BAC, African Institute of Biomedical Science and Technology AiBST, P O Box 2294, Harare, Zimbabwe
    Eur J Clin Pharmacol 64:357-65. 2008
    ..The study sought to investigate the relationship between efavirenz exposure and the CYP2B6 516G-->T(*6) genotype in HIV/AIDS outpatients, using pharmacokinetic modelling and simulation...
  45. ncbi Serum vaspin concentrations are closely related to insulin resistance, and rs77060950 at SERPINA12 genetically defines distinct group with higher serum levels in Japanese population
    Sanae Teshigawara
    Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama 700 8558, Japan
    J Clin Endocrinol Metab 97:E1202-7. 2012
    ..Vaspin is an adipokine with insulin-sensitizing effects identified from visceral adipose tissues of genetically obese rats...
  46. ncbi Prediction of postoperative pulmonary complications in a population-based surgical cohort
    Jaume Canet
    Department of Anesthesiology, Hospital Universitari Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain
    Anesthesiology 113:1338-50. 2010
    ..Hypothesizing that PPC occurrence could be predicted from a reduced set of perioperative variables, we aimed to develop a predictive index for a broad surgical population.
  47. ncbi Resistance training and type 2 diabetes: Considerations for implementation at the population level
    Neil D Eves
    Faculty of Physical Education, University of Alberta, Edmonton, Canada
    Diabetes Care 29:1933-41. 2006
  48. ncbi Genetic composition of Brazilian population samples based on a set of twenty-eight ancestry informative SNPs
    Tulio C Lins
    Programa de Pós Graduação em Ciências Genômicas e Biotecnologia, Universidade Catolica de Brasilia, Brasilia, DF, Brazil
    Am J Hum Biol 22:187-92. 2010
    Ancestry informative SNPs can be useful to estimate individual and population biogeographical ancestry...
  49. pmc The Vermont diabetes information system: a cluster randomized trial of a population based decision support system
    Charles D MacLean
    Division of General Internal Medicine, University of Vermont College of Medicine, 371 Pearl Street, Burlington, VT 05401, USA
    J Gen Intern Med 24:1303-10. 2009
    ..Optimal care for patients with diabetes is difficult to achieve in clinical practice...
  50. ncbi Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century
    Valery L Feigin
    Department of Medicine, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand
    Lancet Neurol 2:43-53. 2003
    This overview of population-based studies of incidence, prevalence, mortality, and case-fatality of stroke was based on studies from 1990...
  51. ncbi Genetic signature of population fragmentation varies with mobility in seven bird species of a fragmented Kenyan cloud forest
    Tom Callens
    Terrestrial Ecology Unit, Department of Biology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    Mol Ecol 20:1829-44. 2011
    Habitat fragmentation can restrict geneflow, reduce neighbourhood effective population size, and increase genetic drift and inbreeding in small, isolated habitat remnants...
  52. ncbi Association of the metabolic syndrome with severe periodontitis in a large U.S. population-based survey
    Francesco D'Aiuto
    UCL Eastman Dental Institute and Hospital, London WC1X 8LD, United Kingdom
    J Clin Endocrinol Metab 93:3989-94. 2008
    ..Metabolic syndrome and periodontitis both have an increasing prevalence worldwide; however, limited information is available on their association...
  53. ncbi Apolipoprotein E gene polymorphism and allele frequencies in the Lebanese population
    Rami A R Mahfouz
    Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Riad El Solh, 1107 2020, P O Box 11 0236, Beirut, Lebanon
    Mol Biol Rep 33:145-9. 2006
    Apolipoprotein E (ApoE) genotypes were studied in order to determine the prevalence in the Lebanese population and compare it with other populations. DNA from 160 unrelated healthy donors from our HLA-bank was used...
  54. ncbi Health-related quality of life in chronic myeloid leukemia patients receiving long-term therapy with imatinib compared with the general population
    Fabio Efficace
    Italian Group for Adult Hematologic Diseases, Data Center and Health Outcomes Research Unit, Rome, Italy
    Blood 118:4554-60. 2011
    ..therapy imatinib have a different health-related quality-of-life (HRQOL) profile compared with the general population. In total, 448 CML patients were enrolled, and the SF-36 Health Survey was used to compare generic HRQOL ..
  55. ncbi Population genetic structure of a nonmigratory estuarine fish (Fundulus heteroclitus) across a strong gradient of polychlorinated biphenyl contamination
    Shaun A Roark
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Environ Toxicol Chem 24:717-25. 2005
    ..Although allele frequencies clearly reflected a pattern of isolation by distance, the results indicated neither significant loss of genetic diversity nor alteration of allele frequencies for populations of F. heteroclitus in NBH...
  56. pmc Lipoprotein-associated phospholipase A(2) mass and activity and risk of cardiovascular disease in a population with high prevalences of obesity and diabetes: the Strong Heart Study
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical Center, New York, New York, USA
    Diabetes Care 35:840-7. 2012
    ..phospholipase A(2) (LpPLA(2)) mass and activity with incident cardiovascular disease (CVD) in a population with high prevalences of insulin resistance and diabetes, conditions for which epidemiological data remain sparse...
  57. pmc Multi-locus inference of population structure: a comparison between single nucleotide polymorphisms and microsatellites
    R J Haasl
    Laboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA
    Heredity (Edinb) 106:158-71. 2011
    ..polymorphisms (SNPs) and microsatellites (short tandem repeat polymorphisms or STRPs) are used to infer population structure, their relative properties in this context remain poorly understood...
  58. ncbi Hurthle cell carcinoma: a population-level analysis of 3311 patients
    Paolo Goffredo
    Milano Bicocca University, Monza, Italy
    Cancer 119:504-11. 2013
    ..To date, there is a paucity of data at a population level...
  59. ncbi A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia
    L Arnheim
    Department of Medicine, Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden
    Tissue Antigens 65:252-9. 2005
    ..There was also no association between KIR genes and type of human papilloma virus or with other CIN-related immune response genes. It was concluded that certain KIR genes and genotypes may associate with cervical neoplasia...
  60. ncbi Harmful alcohol habits were no more common in a sample of newly sick-listed Swedish women and men compared with a random population sample
    G Hensing
    Social Medicine, Department of Public Health and Community Medicine, Institute of Medicine, The Sahlgrenska Academy at the University of Gothenburg, PO Box 453, SE 405 30 Goteborg, Sweden
    Alcohol Alcohol 46:471-7. 2011
    To estimate harmful alcohol habits in a sample of incident sick-listed individuals compared with a random sample from the general population taking social background, health and work-related factors into account.
  61. pmc Ecological and genetic relationships of the Forest-M form among chromosomal and molecular forms of the malaria vector Anopheles gambiae sensu stricto
    Yoosook Lee
    School of Veterinary Medicine, Department of Pathology, Microbiology and Immunology, University of California Davis, Davis, CA, USA
    Malar J 8:75. 2009
    ..Recent studies suggest that the M form found in Cameroon is genetically distinct from the M form found in Mali and elsewhere in West Africa, suggesting further subdivision within that form...
  62. pmc People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population
    Bruce Winney
    Department of Oncology, University of Oxford, ORCRB, Headington, Oxford, UK
    Eur J Hum Genet 20:203-10. 2012
    There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies...
  63. ncbi Vascular risk factors and dementia: 40-year follow-up of a population-based cohort
    Elina Rönnemaa
    Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Science Park, Uppsala, Sweden
    Dement Geriatr Cogn Disord 31:460-6. 2011
    ..Our aim was to evaluate the longitudinal associations of individual and multiple vascular risk factors with the subsequent development of dementia and Alzheimer's disease (AD)...
  64. ncbi Genetic structure in a dynamic baboon hybrid zone corroborates behavioural observations in a hybrid population
    M J E Charpentier
    CEFE CNRS, UMR 5175, Montpellier, France
    Mol Ecol 21:715-31. 2012
    ..Specifically, it suggests that anubis baboons are in the process of gradual range expansion into the range of yellow baboons, a pattern potentially explained by behavioural and life history advantages that correlate with anubis ancestry...
  65. ncbi A comparison of cancer screening practices in cancer survivors and in the general population: the Korean national health and nutrition examination survey (KNHANES) 2001-2007
    Juhee Cho
    Cancer Education Center, Samsung Comprehensive Cancer Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Cancer Causes Control 21:2203-12. 2010
    ....
  66. pmc Low levels of realized seed and pollen gene flow and strong spatial genetic structure in a small, isolated and fragmented population of the tropical tree Copaifera langsdorffii Desf
    A M Sebbenn
    Instituto Florestal de São Paulo, Seção de Melhoramento e Conservação Genética Florestal, Sao Paulo, Sao Paulo, Brazil
    Heredity (Edinb) 106:134-45. 2011
    ..8 ha), isolated population. All 112 adult trees and 128 seedlings found in the stand were sampled, mapped and genotyped...
  67. pmc Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel
    Alison H Harrill
    Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 110:235-43. 2009
    ..Gene expression profiling was performed on liver tissue collected at 24 h after dosing. We identified 26 population-wide biomarkers of response to acetaminophen hepatotoxicity in which the changes in gene expression were ..
  68. ncbi The influence of APOE status on episodic and semantic memory: data from a population-based study
    Lars Göran Nilsson
    Department of Psychology, Stockholm University, Stockholm, Sweden
    Neuropsychology 20:645-57. 2006
    ..On the basis of the data obtained, the authors argue that analyses of the effect of specific genes in cognition should be accompanied by assessment of performance at a specific level, with due attention to the individual's age...
  69. pmc Use of organic nitrates and the risk of hip fracture: a population-based case-control study
    Sander Pouwels
    Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology and Pharmacotherapy, University Utrecht, 3508 TB Utrecht, The Netherlands
    J Clin Endocrinol Metab 95:1924-31. 2010
    ..Moreover, a large Danish case-control study reported a decreased fracture risk. However, the association with duration of nitrate use, dose frequency, and impact of discontinuation has not been extensively studied...
  70. pmc Familial identification: population structure and relationship distinguishability
    Rori V Rohlfs
    Department of Integrative Biology, University of California Berkeley, Berkeley, California, USA
    PLoS Genet 8:e1002469. 2012
    ..Using these confidence intervals, we consider familial searching in a structured population. We show that relatives and unrelated individuals from population samples with lower gene diversity over the ..
  71. pmc Development of ambient air quality population-weighted metrics for use in time-series health studies
    Diane Ivy
    School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA 30332 0512, USA
    J Air Waste Manag Assoc 58:711-20. 2008
    A robust methodology was developed to compute population-weighted daily measures of ambient air pollution for use in time-series studies of acute health effects...
  72. ncbi Population-based versus hospital-based controls: are they comparable?
    Alberto Ruano-Ravina
    Department of Preventive Medicine and Public Health, University of Santiago de Compostela, Spain
    Gac Sanit 22:609-13. 2008
    To compare whether there are differences among hospital and population controls.
  73. pmc The evolutionary dynamics of the lion Panthera leo revealed by host and viral population genomics
    Agostinho Antunes
    Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, United States of America
    PLoS Genet 4:e1000251. 2008
    ..spite of the ability of lions to disperse long distances, patterns of lion genetic diversity suggest substantial population subdivision (mtDNA Phi(ST) = 0.92; nDNA F(ST) = 0...
  74. ncbi The Frontal Assessment Battery (FAB): normative values in an Italian population sample
    I Appollonio
    Neurology Section, Department of Neurosciences, University of Milano Bicocca, S Gerardo Hospital, Via Donizetti 106, I 20052 Monza MI, Italy
    Neurol Sci 26:108-16. 2005
    ..Interestingly, MMSE was significantly correlated with FAB raw scores, whereas adjusted scores were not. The present data may improve the accuracy in the use of the FAB both for clinical and research purposes...
  75. ncbi Cultural and genetic evolution in mountain white-crowned sparrows: song dialects are associated with population structure
    E A MacDougall-Shackleton
    Department of Ecology and Evolutionary Biology, Princeton University, New Jersey 08544 1003, USA
    Evolution 55:2568-75. 2001
    ..Here we test the hypothesis that song dialect, a culturally transmitted trait, is related to the population genetic structure of mountain white-crowned sparrows (Zonotrichia leucophrys oriantha)...
  76. ncbi Incidence and 10-year survival of intracerebral hemorrhage in a population-based registry
    Simona Sacco
    Department of Neurology, University of L Aquila, L Aquila, Italy
    Stroke 40:394-9. 2009
    ..The purpose of this study was to evaluate the incidence and prognosis of intracerebral hemorrhage...
  77. ncbi Population-wide benefits of routine vaccination of children against influenza
    Derek Weycker
    Policy Analysis Inc, Four Davis Court, Brookline, MA 02445, USA
    Vaccine 23:1284-93. 2005
    ..a stochastic simulation model of influenza transmission, clinical illness, and economic costs, we estimated the population-wide benefits of routinely vaccinating US children (ages 6 months to 18 years) against influenza...
  78. ncbi Contrasting demographic history and population structure in Capsella rubella and Capsella grandiflora, two closely related species with different mating systems
    Kate R St Onge
    Department of Plant Ecology and Evolution, Uppsala University, Norbyvagen 18D, 752 36 Uppsala, Sweden
    Mol Ecol 20:3306-20. 2011
    Both mating system and population history can have large impacts on genetic diversity and population structure...
  79. ncbi Population pharmacokinetics of propofol: a multicenter study
    J Schuttler
    Department of Anesthesiology, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Anesthesiology 92:727-38. 2000
    ..This method requires accurate knowledge of pharmacokinetics, including the effects of age and weight. The authors performed a multicenter population analysis to quantitate the effects of covariates.
  80. pmc A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population
    Fan Liu
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Hum Genet 81:17-31. 2007
    ..as part of the Genetic Research in Isolated Populations (GRIP) program that is conducted in a recently isolated population from the southwestern area of The Netherlands...
  81. ncbi Urinary incontinence, overactive bladder, and other lower urinary tract symptoms: a longitudinal population-based survey in men aged 45-103 years
    Ulf G H Malmsten
    Department of Geriatric Medicine, Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    Eur Urol 58:149-56. 2010
    ....
  82. ncbi A population-based study of the prevalence of fatigue after transient ischemic attack and minor stroke
    Charlotte Winward
    Movement Science Group, Oxford Brookes University, Oxford, UK
    Stroke 40:757-61. 2009
    ....
  83. pmc Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide
    Karl Brendel
    INSERM U738, Paris, France
    Pharm Res 23:2036-49. 2006
    The aim of this study is to define and illustrate metrics for the external evaluation of a population model.
  84. pmc Evidence-based reproductive health care in Cameroon: population-based study of awareness, use and barriers
    Alan T N Tita
    MFM Division, Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
    Bull World Health Organ 83:895-903. 2005
    ..To estimate the prevalence of awareness and use of evidence-based reproductive health interventions and to describe the barriers associated with the use of evidence-based interventions among health providers in north-west Cameroon...
  85. ncbi Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study
    Marjo H Eskelinen
    Department of Neurology, University of Kuopio, P O Kuopio, Finland
    J Alzheimers Dis 16:85-91. 2009
    ..the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study were randomly selected from the survivors of a population-based cohorts previously surveyed within the North Karelia Project and the FINMONICA study in 1972, 1977, 1982 ..
  86. ncbi Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban--an oral, direct factor xa inhibitor--in healthy subjects
    W Mueck
    Clinical Pharmacology, Pharmacometry, Bayer HealthCare AG, Wuppertal, Germany
    Int J Clin Pharmacol Ther 45:335-44. 2007
    ..This analysis aimed to define population models for the pharmacokinetics (PK) and pharmacodynamics (PD) ofrivaroxaban in healthy males.
  87. ncbi Bone mineral density in adults with the metabolic syndrome: analysis in a population-based U.S. sample
    Mitsuyo Kinjo
    Teine Keijinkai Hospital, 1 40 Maeda 1 jou 12 chou me, Teine ku, Sapporo City, Hokkaido 006 8555, Japan
    J Clin Endocrinol Metab 92:4161-4. 2007
    ..We examined this relationship in a representative U.S. population-based sample from the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994).
  88. pmc Estimating effective population size and migration rates from genetic samples over space and time
    Jinliang Wang
    Institute of Zoology, Zoological Society of London, London NW1 4RY, United Kingdom
    Genetics 163:429-46. 2003
    In the past, moment and likelihood methods have been developed to estimate the effective population size (N(e)) on the basis of the observed changes of marker allele frequencies over time, and these have been applied to a large variety of ..
  89. pmc Genetic signature of anthropogenic population collapse in orang-utans
    Benoit Goossens
    Biodiversity and Ecological Processes Group, Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    PLoS Biol 4:e25. 2006
    ..Because current demographic collapses are usually confounded by ancient events, this suggests a much more dramatic decline than demographic data alone and emphasises the need for major conservation efforts...
  90. pmc Bayesian estimation of the timing and severity of a population bottleneck from ancient DNA
    Yvonne L Chan
    Department of Biological Sciences, Stanford University, Stanford, California, USA
    PLoS Genet 2:e59. 2006
    ..We estimated the timing and severity of a population bottleneck in an endemic subterranean rodent, Ctenomys sociabilis, over the last 10,000 y from two cave sites in ..
  91. ncbi Quantitative trait loci identified for sugar related traits in a sugarcane (Saccharum spp.) cultivar x Saccharum officinarum population
    K S Aitken
    Queensland Bioscience Precinct, CSIRO Plant Industry, 306 Carmody Rd, St Lucia, QLD, 4067, Australia
    Theor Appl Genet 112:1306-17. 2006
    ..Models including all the QTLs explained from 37 to 66% of the total phenotypic variation, depending on the trait. The results will be subsequently applied in marker assisted breeding...
  92. pmc Complementary and alternative medicine use among cancer survivors: a population-based study
    Jun James Mao
    Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Cancer Surviv 5:8-17. 2011
    ..The use of complementary and alternative medicine (CAM) among cancer survivors is high, yet less is known about reasons behind such use or the communication of CAM with conventional medical providers...
  93. ncbi Significant population variation in adult male height associated with the Y chromosome and the aromatase gene
    J A Ellis
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    J Clin Endocrinol Metab 86:4147-50. 2001
    ..loci are associated with variation in height in 413 adult males and 335 females drawn at random from a large population sample. An association between CYP19 and height was found (difference, 2.0 cm; 95% confidence interval, 0.16-3...
  94. ncbi Effects of mode and intensity on the acute exercise-induced IL-6 and CRP responses in a sedentary, overweight population
    Amy E Mendham
    School of Human Movement Studies, Charles Sturt University, Panorama Avenue, Bathurst, NSW 2795, Australia
    Eur J Appl Physiol 111:1035-45. 2011
    ..Moreover, the exercise modality did not seem to influence the acute IL-6 and CRP response, with the main determinant of the IL-6 response being exercise intensity...
  95. ncbi Biological invasions in agricultural settings: insights from evolutionary biology and population genetics
    Thomas Guillemaud
    Equipe Biologie des Populations en Interaction, UMR 1301 IBSV INRA CNRS, Universite de Nice Sophia Antipolis, 400 Route des Chappes, Sophia Antipolis Cedex, France
    C R Biol 334:237-46. 2011
    ..In this article we suggest that the reconstruction of invasion routes with population genetics-based methods can address fundamental questions in ecology and practical aspects of the management of ..
  96. ncbi The cortisol awakening response and the metabolic syndrome in a population-based sample of middle-aged men and women
    Inger Bengtsson
    Department of Molecular and Clinical Medicine, Sahlgrenska Academy at University of Gothenburg, the Sahlgrenska School of Public Health and Community Medicine, Public Health Epidemiology Unit EPI, Gothenburg, Sweden
    Metabolism 59:1012-9. 2010
    ..study sample consisted of 91 women (14 with MetS) and 84 men (15 with MetS), aged 45 to 70 years, from a general population sample. The only exclusion criteria were no consent, pregnancy, or insufficient cortisol testing...
  97. pmc Smoking and alcohol drinking increased the risk of esophageal cancer among Chinese men but not women in a high-risk population
    Ming Wu
    Jiangsu Provincial Center for Disease Control and Prevention, No 172 Jiangsu Road, Nanjing, Jiangsu, 210009, China
    Cancer Causes Control 22:649-57. 2011
    ..effect of smoking and alcohol consumption with esophageal cancer in China, particularly among Chinese women, a population-based case-control study has been conducted in Jiangsu, China, from 2003 to 2007...
  98. ncbi Prevalence of major depression and stress indicators in the Danish general population
    L R Olsen
    Psychiatric Research Unit, Frederiksborg General Hospital, Hilleroed, Denmark
    Acta Psychiatr Scand 109:96-103. 2004
    To estimate the prevalence rate of major depression in the Danish general population by using the Major Depression Inventory (MDI), a validated self-rating scale fulfilling the symptomatic criteria in DSM-IV and ICD-10 for a depressive ..
  99. pmc Population pharmacokinetics of Arbekacin in patients infected with methicillin-resistant Staphylococcus aureus
    Yusuke Tanigawara
    Department of Hospital Pharmacy, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Antimicrob Agents Chemother 50:3754-62. 2006
    ..The population pharmacokinetics of arbekacin was investigated in the Japanese, using 353 patients infected with MRSA and 50 ..
  100. ncbi Population proteomics: an emerging discipline to study metapopulation ecology
    David G Biron
    GEMI UMR CNRS IRD 2724, Equipe Evolution des Systèmes Symbiotiques, IRD, Montpellier, France
    Proteomics 6:1712-5. 2006
    ..Traditionally, population genetics is the main tool used to studying metatopulations, as it describes the spatial structure of populations ..
  101. ncbi Prevalence of antibodies to Trypanosoma cruzi among solid organ donors in Southern California: a population at risk
    Marek J Nowicki
    National Institute of Transplantation, Los Angeles, CA 90057, USA
    Transplantation 81:477-9. 2006
    ..One donor (0.25%) had an IFA-confirmed reactivity to anti-T. cruzi antibodies. In areas where there is a high number of immigrants from T. cruzi endemic countries, screening for anti-T. cruzi donor antibodies may be beneficial...

Research Grants72

  1. Epidemiologic Research and Surveillance in Epilepsy (U01) Component A
    Barbara L Kroner; Fiscal Year: 2013
    ..of the epidemiology of pediatric epilepsy in a geographic area with a racially and economically diverse population. Children in DC are among the most racially and socioeconomically diverse populations in the country, with ..
  2. Calculations, Word Problems, and Algebraic Cognition
    Lynn S Fuchs; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Mathematics learning disabilities (MLD) affect 5-9% of the school-age population, leading to life-long difficulties that create financial burdens and a public health problem for society...
  3. Mechanisms of Reading-Related Dysfunction in Fetal Alcohol Spectrum Disorders
    LEILA BETH GLASS; Fiscal Year: 2013
    ..children and access to effective treatment can lead to better outcomes;however, both have been limited in this population. Effective interventions must target clinically relevant cognitive functions to help improve academic ..
  4. Quantifying Contact Rates and Mixing Patterns in School Age Children
    Shanta M Zimmer; Fiscal Year: 2012
    ..regarding social contacts, mixing patterns, and the spread of common infectious diseases in the school-age population. As reinforced by the recent novel H1N1 pandemic, infectious diseases spread efficiently through the school-age ..
  5. AUDITORY TEMPORAL PROCESSING IN CHILDREN WITH DSYLEXIA
    Joshua Breier; Fiscal Year: 2000
    ..with dyslexia, or specific reading disability (RD), a condition that affects 5 to 17 percent of the school-age population, depending on how it is defined...
  6. Sound Contrast in Phonology (SCIP)
    JOYCE OLSON; Fiscal Year: 2005
    ..The commercial potential of SCIP is expected to be high, given that there are over 94,000 certified SLPs in the U.S., many of whom serve the 10-15% of the preschool and 6% of the school-age population who exhibit a speech disorder.
  7. BALTIMORE PEDIATRIC EYE SURVEY
    James Tielsch; Fiscal Year: 2007
    ..A number of population-based studies in a variety of major ethnic groups in the United States have provided critical information for ..
  8. Variability in phonological/articulatory disorders
    Karen Forrest; Fiscal Year: 2006
    ..DESCRIPTION (provided by applicant): It is estimated that approximately 20% of the preschool and school age population demonstrate speech acquisition disorders that are not attributable to an organic cause (NIDCD, 1994)...
  9. Race & Breast Cancer Estrogen Receptor Status: Impact of Class and Missing Data
    Nancy Krieger; Fiscal Year: 2007
    ..position, we will employ multivariate and sensitivity analysis techniques to analyze a multi- racial/ethnic population-based data set consisting of all incident cases of invasive primary breast cancer among women (n = 42,240 ..
  10. Racial Discrimination and Risk of Chronic Disease
    Nancy Krieger; Fiscal Year: 2010
    ..The study population will consist of a random sample of 1000 US-born non-Hispanic black and white adults (ages 35-64, 500 in each ..
  11. AREA-BASED SOCIOECONOMIC MEASURES FOR HEALTH DATA
    Nancy Krieger; Fiscal Year: 2003
    ..In doing so, our project incorporates socioeconomic data, a powerful determinant of population health, disease, and well-being, into routinely collected public health data and greatly augments capacity to: (..
  12. Geocoding, Census Data & Social Disparities in Health
    Nancy Krieger; Fiscal Year: 2005
    ..of our proposed educational program on "Geocoding, census data & social disparities in health" is to educate population researchers and data analysts in concepts, methods, and approaches to geocoding public health data, generating ..
  13. Socioeconomic Trends in Breast Cancer Incidence
    Nancy Krieger; Fiscal Year: 2005
    ..the 1970-2000 decennial censuses for periods straddling each census, and explore methods to estimate intercensal population counts...
  14. Breast Cancer After The Women?s Health Initiative Study: Declining Incidence?
    Nancy Krieger; Fiscal Year: 2008
    ..We propose to build on these 2 studies by using data from two US population-based cancer registries for the years 1995-2005 to examine whether breast cancer incidence has declined since ..
  15. Functions of Very Large G-protein Coupled Receptor-1
    Perrin White; Fiscal Year: 2008
    ..We are specifically interested in the other proteins with very large ectodomains, protocadherin- 15 and cadherin-23. These studies should shed new light on mechanisms controlling development of the retina and inner ear. ..
  16. Genes Underlying the Response to Inhaled Anesthetics
    James Sonner; Fiscal Year: 2008
    ....
  17. DOT and Prevention for HIV(+) Persons Leaving Prison
    Jennifer Mitty; Fiscal Year: 2008
    ..Acceptability and feasibility of the intervention will be evaluated, as well as efficacy of the intervention on plasma viral load suppression and self-reported HIV-risk behaviors during the first 6 months post release. ..
  18. Effect of Caffeine on Functional and Perfusion MRI
    PAUL LAURIENTI; Fiscal Year: 2008
    ..applicant): Caffeine is the most widely used neurostimulant in the world, and it has been shown that 79% of the population in the United States drinks coffee at least occasionally...
  19. The impact of the built environment on the risk of breast cancer
    THERESA KEEGAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. Biochemical Basis of Cortisone Reductase Deficiency
    Perrin White; Fiscal Year: 2007
    ..Subsets of the genotyping data will be analyzed as an association study, as an affected sib pair study, and by transmission disequilibrium testing. Additional polymorphisms in these genes will be sought in PCOS subjects. ..
  21. Neighborhood SES and behavioral pathways to risk of colorectal cancer in women
    Daniel Kim; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. Renal Cl channel polymorphisms and blood pressure
    Saba Sile; Fiscal Year: 2007
    ....
  23. Hospital-Acquired Infections in the Elderly
    Keith Kaye; Fiscal Year: 2008
    ..The risk factor identified for SSI and MDRB and the impact of SSI and MDRB on health outcomes will be used to design and implement future preventive interventions. ..
  24. Heterogeneous Treatment Effects in Social and Behavioral Sciences
    Yu Xie; Fiscal Year: 2010
    ..In addition to scientific articles, a book resulting from the project will be produced that will be accessible to a wide variety of social, behavioral and medical scientists. ..
  25. Local Adaptations in Humans
    Anna Di Rienzo; Fiscal Year: 2010
    ..Moreover, it will yield important insights into the demographic and selective factors that shape disease susceptibility loci. ..
  26. Evolutionary Genetics of the Metabolic Syndrome
    Anna Di Rienzo; Fiscal Year: 2010
    ..In this multi-investigator proposal, we will address population genetics hypotheses in the following specific aims: 1...
  27. DEMOGRAPHIC STUDY OF MULTIPLE CAUSES OF DEATH
    Kenneth Manton; Fiscal Year: 2008
    Total mortality in the U.S. elderly population has changed significantly due to declines in heart disease, and stroke and, recently, (> 1990) cancer mortality...
  28. Database of Functional SNPs in Cancer-Related Environmentally Responsive Genes
    Yong Zhu; Fiscal Year: 2009
    ..Findings from this study will enhance the use of SNPs in future phenotypic studies and molecular epidemiologic approaches to address questions related to gene-environment interaction in disease risk estimate. ..
  29. REGULATION OF SECRETION FROM HUMAN BASOPHILS
    Donald MacGlashan; Fiscal Year: 2009
    ..A population of subjects will be examined for this relationship.
  30. HAWAII ACTU - ADULT THERAPEUTIC CLINICAL TRIALS PROGRAM
    Cecilia Shikuma; Fiscal Year: 2008
    ..currently meeting all ACTG standards for site operations; 2)Access to Hawaii's ethnically diverse population, havingpreviously contributed41% of all ACTG's enrollees of Asian/Pacific Islander descent; 3) A ..
  31. Individual Propensity to Venous Thrombosis
    John Heit; Fiscal Year: 2009
    ..However, the incidence of VTE has remained relatively constant at about 1 per 1000 since 1980. Clearly, better methods of targeting VTE prophylaxis are needed. ..
  32. Role of macrophages in HIV Lipoatrophy
    Cecilia M Shikuma; Fiscal Year: 2010
    ..We are particularly well suited to undertake these studies as our research team combines clinical research expertise in HIV lipoatrophy with specific laboratory competency in adipose tissue-, mitochondrial- and M/MO-related research. ..
  33. AUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRY
    John Hopper; Fiscal Year: 2007
    ..Recruit 320 population-based colorectal cancer cases diagnosed before the age of 50, regardless of family history, and 250 clinic-based ..
  34. Gene Polymorphism & Treatment-Symptoms in Lung Cancer
    Cielito Reyes Gibby; Fiscal Year: 2008
    ..abstract_text> ..
  35. Tobacco Treatment Initiated in the Emergency Department
    Edwin Boudreaux; Fiscal Year: 2007
    ..The research plan includes preparing and submitting an R01 in Year 2. ..
  36. Using Third-Party Data in Pedigree and Subgroup Analyses
    MORRIS FOSTER; Fiscal Year: 2005
    ..Doing so will allow us to construct extended pedigrees and population subgroups that we will then use to investigate the scientific and clinical value of more rigorously specified ..
  37. Kinetics of Ligand Binding to Synaptic Ion Channels
    JAMES DILGER; Fiscal Year: 2006
    ..4. Use isothermal titration calorimetry to measure the thermodynamics of ligand binding to acetylcholine binding protein - a water soluble protein whose structure is being used as a template for the acetylcholine receptor. ..
  38. FUNCTIONAL AND HEALTH CHANGES OF THE ELDERLY
    Kenneth Manton; Fiscal Year: 2002
    ....
  39. Socioeconomic Disparities in Survival After Hodgkin Lym*
    THERESA KEEGAN; Fiscal Year: 2005
    ..Census SES data and with hospital and physician characteristics, we will undertake an efficient, cost-effective, population-based secondary data analysis to examine the effects of neighborhood SES on long-term survival following HL...
  40. HEALTH PROMOTION THROUGH BLACK CHURCHES
    Ken Resnicow; Fiscal Year: 2004
    ..Recruitment and retention of participants will be maximized by several strategies including incentives for each church, and the use of church liaisons to assist in participant recruitment and tracking. ..
  41. BIOPHILE-80C Storage Unit with Individual Vial Retriever
    Joshua Labaer; Fiscal Year: 2004
    ..While manual distribution accommodates fewer than 100 clones per day, the BIOPHILE has a capacity of 1,200 clones per day. ..
  42. EFFECTS OF ALCOHOL ABUSE ON THE AGING BRAIN
    George Fein; Fiscal Year: 2004
    ..g., brain "functional reserve," presence of the APOE-epsilon4 allele) that may modulate the effects of chronic alcohol abuse/dependence and age on brain structure and function. ..
  43. Racial Differences--Stress Induced Homeostatic Response
    Gregory Harshfield; Fiscal Year: 2005
    ..abstract_text> ..
  44. Genetic Polymorphisms Benign Prostatic Hyperplasia
    ROSEBUD ROBERTS; Fiscal Year: 2004
    ..This community-based cohort study should provide insights that should improve our understanding of the genetic control of hormonal mechanisms in the pathogenesis of BPH. ..
  45. OBESITY PREVENTION IN BLACK TEENS: GO GIRLS! II
    Ken Resnicow; Fiscal Year: 2003
    ..low income overweight African American adolescents, will be adapted to a middle/upper income African American population. Stage 1 will culminate in a 12-week pilot of the intervention in two churches...
  46. LONGITUDINAL LDL-C STUDIES IN BLACK AND WHITE FAMILIES
    John Morrison; Fiscal Year: 2003
    ..They conclude that this information can be used to improve prediction of future CHD risk and to formulate interventions. ..
  47. Thrombophilia In Cryptogenic Stroke (THICK) Study
    JORGE KIZER; Fiscal Year: 2006
    ..Interactions among thrombophilias, thrombophilias and traditional cardiovascular risk factors, and thrombophilias and other potential cardiac sources of embolism will also be investigated. ..
  48. Impaired Sodium Regulation and BP in Obese Youth
    Gregory Harshfield; Fiscal Year: 2006
    ..Finally, measures of target organ change will include left ventricular mass, diastolic function, and glomerular hyperfiltration as estimated from creatinine clearance. ..
  49. MOLECULAR GENETICS OF LOW RENIN HYPERTENSION
    Perrin White; Fiscal Year: 2001
    ..The investigators will determine the role of 11-HSD K in the development of essential hypertension, using both linkage and association studies. ..
  50. BEHAVIORAL STRESS AND SODIUM REGULATION IN YOUTHS
    Gregory Harshfield; Fiscal Year: 2001
    ..It will also define the hemodynamic response pattern associated with these changes. Finally, this study will examine these questions in a younger cohort than has been studied previously, providing new information on this population.
  51. TREATMENT FOR DUALLY DEPENDENT METHADONE PATIENTS
    Nancy Petry; Fiscal Year: 2002
    ..Only three controlled clinical trials have demonstrated significant reductions in alcohol use in this population. All three studies showed that an intervention in which disulfiram ingestion was necessary for methadone ..
  52. Tobacco Control in S.Africa: Prevention and Capacity Bu*
    Ken Resnicow; Fiscal Year: 2006
    ..abstract_text> ..
  53. Functional Proteomics of Breast Cancer
    Joshua Labaer; Fiscal Year: 2006
    ..We will demonstrate the effectiveness of this approach by executing a 1000 x 1000 interaction matrix with the BC1000. ..
  54. Testing Segmented Assimilation Theory with Add Health
    Yu Xie; Fiscal Year: 2006
    ..The research will provide a rigorous, systematic, and scientific test of segmented assimilation theory with an excellent and unique data source. ..
  55. AFRICAN AMERICAN COMMUNITY REVIEW OF GENETIC RESEARCH
    MORRIS FOSTER; Fiscal Year: 2005
    ..to Oklahoma in the 1830s by slave-owning members of the Five Civilized Tribes; and 3) the urban African American population of Oklahoma City, which is comprised of complex, heterogeneous, and overlapping local social networks and ..
  56. Neurobiologic Study of Psychological Distress & Dementia
    Robert S Wilson; Fiscal Year: 2010
    ....
  57. Training Multisensory Processing in Older Adults
    PAUL LAURIENTI; Fiscal Year: 2007
    ..Thus, studies directed at evaluating the clinical efficacy of multisensory training programs could have considerable impact on health care and the quality of life in the elderly. [unreadable] [unreadable] [unreadable]..
  58. The Computer Assisted Brief Intervention for Tobacco (CABIT)
    Edwin Boudreaux; Fiscal Year: 2007
    ..g., JCAHO) and to facilitate financial reimbursement of tobacco counseling covered by Medicare and other third party providers. [unreadable] [unreadable] [unreadable]..
  59. Integrating Sex & Drug Related HIV Risk & Transmission
    Robert Heimer; Fiscal Year: 2007
    ..transmission of HIV and other pathogens among populations of drug users and from drug users to the broader population; 2) to employ a multidisciplinary approach to investigate the dynamics of sexual and syringe-borne disease ..
  60. The Dynamic Assessment and Referral System for Substance Abuse (DARSSA)
    Edwin Boudreaux; Fiscal Year: 2006
    ..g., Medicare). [unreadable] [unreadable] [unreadable]..
  61. Patterns and Predictors of Cognitive Decline
    KENNETH LANGA; Fiscal Year: 2008
    ..To perform these studies we will use unique linked population-based data from the NIA-funded Health and Retirement Study (MRS) (N~22,000; 1992 - 2004), the MRS supplemental ..
  62. Using light to increase visual and perceptual cues and decrease falls risk
    MARIANA FIGUEIRO; Fiscal Year: 2010
    ..2004). Neural changes also become problematic for the oldest people in our population. Gibson (1966) describes a number of higher-order perceptual phenomena that can be compromised in seniors...
  63. SYRINGE EXCHANGE BASED HEPATITIS B VACCINATION OF IDU'S
    Robert Heimer; Fiscal Year: 2005
    ....
  64. Multicenter Pilot Studies for ED Tobacco Interventions
    Edwin Boudreaux; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  65. Study Designs & Analytic Strategies for Environmental & Policy Research in Obesit
    James Sallis; Fiscal Year: 2008
    ..New investigators and minority investigators will be invited to participate in the conference. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  66. Ecological Analysis of Physical Activity
    James Sallis; Fiscal Year: 2004
    ..Results will inform public health, land use, and transportation policies that could have population-wide impacts on physical activity.
  67. Spousal communication and cancer prevention behavior
    KELLY EVENSON; Fiscal Year: 2006
    ..The long-term goal of this research is to develop better interventions which help prevent cancer, and other chronic health conditions, by involving spouses in preventive behavior change programs. [unreadable] [unreadable]..
  68. Understanding Change in Physical Activity Postpartum
    KELLY EVENSON; Fiscal Year: 2009
    ..This proposal directly addresses the need to better understand multi-level factors involved in physical activity behavior change, RFA #CA-04-009 "Mechanisms of Physical Activity Behavior Change". ..
  69. CENTER FOR LONGITUDINAL ANALYSIS IN MEDICAL DEMOGRAPHY
    Kenneth Manton; Fiscal Year: 2004
    ..The areas promoted in the P30 Center include biodemography, medical demography, studies of the oldest-old population, genetics of aging and chronic diseases, long-term care, and caregiver services, cost of illness, health and ..
  70. ACTIVE LIFE EXPECTANCY IN OLD AND OLDEST OLD POPULATIONS
    Kenneth Manton; Fiscal Year: 2002
    ..the years of life expected to be lived without serious disability) using multidimensional stochastic process population models applied to, initially, the 1982, 1984, 1989 and 1994 National Long Term Care Surveys (NLTCS) and ..
  71. FUNCTIONAL AND HEALTH CHANGES OF THE ELDERLY
    Kenneth Manton; Fiscal Year: 2006
    REVISED It is proposed to conduct a 2004 National Long Term Care Survey (NLTCS) of the U.S. population aged 65+ to analyze trends in the population risks of chronic disability, severe cognitive impairment, and mortality...