antisepsis

Summary

Summary: The destruction of germs causing disease.

Top Publications

  1. ncbi An evaluation of preoperative skin antiseptics
    Allyson Lipp
    School of Care Sciences, University of Glamorgan, Glyntaff, Pontypridd
    Br J Perioper Nurs 15:12-4, 16-9. 2005
  2. ncbi Comparison of two alcohol-based surgical scrub solutions with an iodine-based scrub brush for presurgical antiseptic effectiveness in a community hospital
    C Gupta
    St John North Shores Hospital, Harrison Township, Michigan, USA
    J Hosp Infect 65:65-71. 2007
  3. ncbi Povidone-iodine: use in hand disinfection, skin preparation and antiseptic irrigation
    Piyush Durani
    Department of Plastic, Reconstructive and Burns Surgery, Nottingham City Hospital, Hucknall Road, Nottingham, UK
    Int Wound J 5:376-87. 2008
  4. ncbi Safety of chlorhexidine gluconate used for skin antisepsis in the preterm infant
    A K Chapman
    Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Perinatol 32:4-9. 2012
  5. ncbi Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis
    Rabih O Darouiche
    Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 362:18-26. 2010
  6. ncbi Limb wounding and antisepsis: iodine and chlorhexidine in the early management of extremity injury
    William G P Eardley
    Royal Centre for Defence Medicine, Birmingham, UK
    Int J Low Extrem Wounds 11:213-23. 2012
  7. ncbi Chlorhexidine-alcohol compared with povidone-iodine for surgical-site antisepsis in cesarean deliveries
    Gulden Menderes
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Obstet Gynecol 120:1037-44. 2012
  8. ncbi A fall in bloodstream infections followed a change to 2% chlorhexidine in 70% isopropanol for catheter connection antisepsis: a pediatric single center before/after study on a hemopoietic stem cell transplant ward
    James S Soothill
    Department of Microbiology, Level 4 CB Labs, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Am J Infect Control 37:626-30. 2009
  9. ncbi Surgical hand antisepsis: the evidence
    Judith Tanner
    De Montfort University and University Hospitals Leicester, Charles Frears Campus, 266 London Road, Leicester LE2 1RQ
    J Perioper Pract 18:330-4, 339. 2008
  10. pmc The forgotten role of alcohol: a systematic review and meta-analysis of the clinical efficacy and perceived role of chlorhexidine in skin antisepsis
    Matthias Maiwald
    Department of Pathology and Laboratory Medicine, KK Women s and Children s Hospital, Singapore, Singapore
    PLoS ONE 7:e44277. 2012

Detail Information

Publications232 found, 100 shown here

  1. ncbi An evaluation of preoperative skin antiseptics
    Allyson Lipp
    School of Care Sciences, University of Glamorgan, Glyntaff, Pontypridd
    Br J Perioper Nurs 15:12-4, 16-9. 2005
    ..Taking this perspective, the author recently contributed to a systematic review evaluating the use of antiseptics preoperatively...
  2. ncbi Comparison of two alcohol-based surgical scrub solutions with an iodine-based scrub brush for presurgical antiseptic effectiveness in a community hospital
    C Gupta
    St John North Shores Hospital, Harrison Township, Michigan, USA
    J Hosp Infect 65:65-71. 2007
    ..001). Although both of the commercially available alcohol-based solutions may be considered as acceptable alternatives to the BBIS for presurgical antisepsis, the ABWL was found to have significantly higher user acceptability.
  3. ncbi Povidone-iodine: use in hand disinfection, skin preparation and antiseptic irrigation
    Piyush Durani
    Department of Plastic, Reconstructive and Burns Surgery, Nottingham City Hospital, Hucknall Road, Nottingham, UK
    Int Wound J 5:376-87. 2008
    ..This evidence suggests that the use of povidone-iodine as an agent of choice is dependent on the clinical need but is also likely to be influenced by personal preference...
  4. ncbi Safety of chlorhexidine gluconate used for skin antisepsis in the preterm infant
    A K Chapman
    Division of Neonatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Perinatol 32:4-9. 2012
    ..CHG is, however, frequently used in Neonatal Intensive Care Units across the United States. Here, we will review the safety of CHG use in preterm infants...
  5. ncbi Chlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis
    Rabih O Darouiche
    Michael E DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    N Engl J Med 362:18-26. 2010
    ..skin is a major source of pathogens that cause surgical-site infection, optimization of preoperative skin antisepsis may decrease postoperative infections...
  6. ncbi Limb wounding and antisepsis: iodine and chlorhexidine in the early management of extremity injury
    William G P Eardley
    Royal Centre for Defence Medicine, Birmingham, UK
    Int J Low Extrem Wounds 11:213-23. 2012
    ..are ubiquitous in other aspects of health care however, and a plethora of studies detail their role in skin antisepsis, the recommendations from which are often anecdotally applied to acute wounding...
  7. ncbi Chlorhexidine-alcohol compared with povidone-iodine for surgical-site antisepsis in cesarean deliveries
    Gulden Menderes
    Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA
    Obstet Gynecol 120:1037-44. 2012
    ..To estimate the incidence of surgical-site infection with use of chlorhexidine-alcohol compared with povidone-iodine among women undergoing cesarean deliveries...
  8. ncbi A fall in bloodstream infections followed a change to 2% chlorhexidine in 70% isopropanol for catheter connection antisepsis: a pediatric single center before/after study on a hemopoietic stem cell transplant ward
    James S Soothill
    Department of Microbiology, Level 4 CB Labs, Great Ormond Street Hospital for Children NHS Trust, London, UK
    Am J Infect Control 37:626-30. 2009
    Some catheter-related bloodstream infections originate from catheter connectors; therefore, improved antisepsis of these might be expected to reduce the incidence of such infections.
  9. ncbi Surgical hand antisepsis: the evidence
    Judith Tanner
    De Montfort University and University Hospitals Leicester, Charles Frears Campus, 266 London Road, Leicester LE2 1RQ
    J Perioper Pract 18:330-4, 339. 2008
    ..This article discusses the evidence surrounding aspects of surgical hand antisepsis.
  10. pmc The forgotten role of alcohol: a systematic review and meta-analysis of the clinical efficacy and perceived role of chlorhexidine in skin antisepsis
    Matthias Maiwald
    Department of Pathology and Laboratory Medicine, KK Women s and Children s Hospital, Singapore, Singapore
    PLoS ONE 7:e44277. 2012
    Skin antisepsis is a simple and effective measure to prevent infections. The efficacy of chlorhexidine is actively discussed in the literature on skin antisepsis...
  11. ncbi Surgical hand antisepsis in veterinary practice: evaluation of soap scrubs and alcohol based rub techniques
    Denis R Verwilghen
    Equine Clinic, Department of Clinical Sciences of Companion Animals and Equids, Faculty of Veterinary Medicine of Liege, Bld de Colonster 20 B41, 4000 Liege, Belgium
    Vet J 190:372-7. 2011
    ..that hydro-alcoholic solutions are more efficient than traditional medicated soaps in the pre-surgical hand antisepsis of human surgeons but there is little veterinary literature on the subject...
  12. ncbi Cathelicidins and functional analogues as antisepsis molecules
    Neeloffer Mookherjee
    University of British Columbia, Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, Vancouver, BC, Canada
    Expert Opin Ther Targets 11:993-1004. 2007
    ..peptides to selectively suppress harmful pro-inflammatory responses, while maintaining beneficial infection-fighting components of host innate defences makes them a good model for antisepsis therapies that merit further investigation.
  13. ncbi Guidelines for the prevention of intravascular catheter-related infections. The Hospital Infection Control Practices Advisory Committee, Center for Disease Control and Prevention, U.S
    NAOMI P O'GRADY
    National Institutes of Health, Department of Critical Care Medicine, Bethesda, Maryland 20892, USA
    Pediatrics 110:e51. 2002
    ..barrier precautions during central venous catheter insertion; 3) using a 2% chlorhexidine preparation for skin antisepsis; 4) avoiding routine replacement of central venous catheters as a strategy to prevent infection; and 5) using ..
  14. ncbi Prospective randomized trial of 3 antiseptic solutions for prevention of catheter colonization in an intensive care unit for adult patients
    J Valles
    Critical Care Center, Hospital Sabadell, Institut Universitari Parc Tauli, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Sabadell, Spain
    Infect Control Hosp Epidemiol 29:847-53. 2008
    To compare the effectiveness for prevention of central venous and arterial catheter colonization of 3 skin antisepsis with 1 of 3 antiseptic solutions: 10% aqueous povidone iodine (aqueous PI), 2% aqueous chlorhexidine gluconate (aqueous ..
  15. ncbi The role of iodine in antisepsis and wound management: a reappraisal
    G Selvaggi
    Plastic Surgery Department, Gent University Hospital, Gent, Belgium
    Acta Chir Belg 103:241-7. 2003
    ..After new developments and publications, the role of iodine in antisepsis and in wound management needs to be reevaluated...
  16. pmc Safety and impact of chlorhexidine antisepsis interventions for improving neonatal health in developing countries
    Luke C Mullany
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21211, USA
    Pediatr Infect Dis J 25:665-75. 2006
    ..Efficacy trials for all chlorhexidine interventions are needed in low-resource settings in Africa, and the benefit of maternal vaginal cleansing beyond that provided by newborn skin cleansing needs to be determined...
  17. ncbi Analyses comparing the antimicrobial activity and safety of current antiseptic agents: a review
    John S Hibbard
    J Infus Nurs 28:194-207. 2005
    ....
  18. ncbi Blood culture contamination rates after skin antisepsis with chlorhexidine gluconate versus povidone-iodine in a pediatric emergency department
    Lauren Marlowe
    University of Pennsylvania School of Medicine, Philadelphia, USA
    Infect Control Hosp Epidemiol 31:171-6. 2010
    To determine blood culture contamination rates after skin antisepsis with chlorhexidine, compared with povidone-iodine.
  19. ncbi Skin antisepsis kits containing alcohol and chlorhexidine gluconate or tincture of iodine are associated with low rates of blood culture contamination
    Barbara W Trautner
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA
    Infect Control Hosp Epidemiol 23:397-401. 2002
    ..We assessed blood culture contamination rates associated with the use of skin antisepsis kits containing either 2% alcoholic chlorhexidine gluconate or 2% alcoholic tincture of iodine.
  20. pmc Comparison of chlorhexidine and tincture of iodine for skin antisepsis in preparation for blood sample collection
    Joan Barenfanger
    Laboratory Medicine, Memorial Medical Center, Springfield, Illinois 62781, USA
    J Clin Microbiol 42:2216-7. 2004
    ..7%; for chlorhexidine, it was 3.1%. The 0.41% difference is not statistically significant. Chlorhexidine has comparable effectiveness and is safer, cheaper, and preferred by staff, so it is an alternative to iodine tincture...
  21. ncbi Effectiveness of Chloraprep in reduction of blood culture contamination rates in emergency department
    Dwayne Tepus
    Summa Health System, Akron, Ohio 44304, USA
    J Nurs Care Qual 23:272-6. 2008
    ..Adoption of this technique throughout our institution is expected to result in a savings of 875000 dollars per year, as well as decreased discomfort for the patient...
  22. ncbi Evaluation of ChloraPrep (2% chlorhexidine gluconate in 70% isopropyl alcohol) for skin antisepsis in preparation for blood culture collection
    E McLellan
    Department of Microbiology, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Herries Road, Sheffield S5 7AU, United Kingdom
    J Infect 57:459-63. 2008
    ..This study evaluated whether using ChloraPrep (2% alcoholic chlorhexidine) instead of 70% isopropyl alcohol wipes reduced contamination rates on two Medical Assessment Units (MAU1 and MAU2)...
  23. ncbi Chlorhexidine and alcohol versus povidone-iodine for antisepsis in gynecological surgery
    Ishai Levin
    Department of Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Womens Health (Larchmt) 20:321-4. 2011
    Surgical site infections (SSIs) cause severe morbidity and are associated with tremendous health costs. Skin antisepsis (cleansing) with chlorhexidine and alcohol solutions has demonstrated superiority to povidone-iodine in a variety of ..
  24. ncbi Why is it that internists do not follow guidelines for preventing intravascular catheter infections?
    Lewis Rubinson
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Infect Control Hosp Epidemiol 26:525-33. 2005
    ..for the use of maximal barrier precautions (mask, sterile gloves, gown, and large drape) and skin antisepsis with 2% chlorhexidine gluconate during CVC insertion, internists in the United States are not implementing these ..
  25. ncbi Operating room management: operative suite considerations, infection control
    Maria D Allo
    Department of Surgery, Santa Clara Valley Medical Center, 751 South Bascom Avenue, San Jose, CA 95128, USA
    Surg Clin North Am 85:1291-7, xii. 2005
    ..Guidelines should be consulted and incorporated into each operating room's policies and procedures...
  26. ncbi [Hygienic and dermatologic aspects of hand disinfection and prophylactic skin antisepsis]
    A Kramer
    Institut fur Hygiene und Umweltmedizin, Ernst Moritz Arndt Universitat Greifswald
    Hautarzt 56:743-51. 2005
    ..The regular use of skin care and skin protection products can help to prevent toxic skin irritation. For skin antisepsis the recommended exposure times are > or =15 seconds before subcutaneous injections, > or =1 minute before ..
  27. ncbi On washing hands
    Atul Gawande
    Department of Surgery, Brigham and Women s Hospital, Boston, USA
    N Engl J Med 350:1283-6. 2004
  28. ncbi Key points in the CDC's surgical site infection guideline
    Anne Woods
    Chandler Hall Wellness Center, Newtown, PA, USA
    Adv Skin Wound Care 18:215-20. 2005
  29. ncbi [Hand antisepsis: is it time to use alcohol?]
    Paul Le Guerrier
    Departement de Medecine sociale et preventive, l Université de Montréal
    Perspect Infirm 1:36-7, 40-4. 2004
  30. ncbi A cost comparison of hand hygiene regimens
    Jeannie P Cimiotti
    Columbia University School of Nursing, New York, NY, USA
    Nurs Econ 22:196-9, 204, 175. 2004
    ..A waterless alcohol-based rub was significantly less costly than traditional handwashing because of reduced time required, and was associated with significantly better quality...
  31. ncbi Management of wound infection after appendectomy: are parenteral antibiotics useful?
    B Harahsheh
    Department of Surgery, King Hussein Medical Centre, Royal Medical Services, Amman, Jordan
    East Mediterr Health J 8:638-44. 2002
    ..We conclude that antibiotics do not offer any advantage in post-appendectomy wound infections except for cases of perforated appendix...
  32. ncbi Antisepsis for abdominal hysterectomy: a randomised controlled trial of povidone-iodine gel
    E Eason
    Department of Obstetrics and Gynaecology, University of Ottawa, Canada
    BJOG 111:695-9. 2004
    ..To assess whether infectious morbidity after total abdominal hysterectomy is decreased by the addition of 20 cc povidone-iodine gel at the vaginal apex after the usual vaginal preparation with povidone-iodine solution...
  33. ncbi The evolution: Handwashing to hand hygiene guidance
    Nancy B Bjerke
    Crit Care Nurs Q 27:295-307. 2004
    ..In healthcare, the principle of "clean hands are healing hands" bears value and demands compliance in order to prevent and control infectious processes while protecting the person from acquiring infectious diseases...
  34. ncbi Monitoring quality of flexible endoscope disinfection by microbiologic surveillance cultures
    Anuradha Tunuguntla
    East Tennessee State University, Johnson City, USA
    Tenn Med 97:453-6. 2004
    ..The purpose of this study is to assess the adequacy of currently approved high-level disinfection (HLD) for flexible endoscopes, by reviewing retrospectively the results of environmental cultures on the endoscopes, which were ready to use...
  35. ncbi Hand scrub products--performance requirements versus clinical relevance
    Daryl S Paulson
    Bioscience Laboratories, Inc, Bozeman, Mont, USA
    AORN J 80:225-34. 2004
    ..Although the test currently used to validate surgical hand scrub products is rigorous in research methodology, it lacks practical clinical relevance...
  36. ncbi Killing germs: antisepsis, disinfection, and sterilization in underserved countries
    Sandra J Pfaff
    Plast Surg Nurs 25:140-9; quiz 150-1. 2005
  37. ncbi Sterility of surgical site marking
    Geoffrey Cronen
    Department of Orthopaedics, West Virginia University, P O Box 9196, Health Sciences Center, Morgantown, WV 26506 9196, USA
    J Bone Joint Surg Am 87:2193-5. 2005
    ..In this study, we determined whether marking of the site affected the sterility of the surgical field...
  38. ncbi Impact of newborn skin-cleansing with chlorhexidine on neonatal mortality in southern Nepal
    Sourabh Dutta
    Pediatrics 120:693-4; author reply 694-5. 2007
  39. ncbi Resistance of antimicrobial skin preparations to saline rinse using a seeded bacteria model
    Julie B Stahl
    3M Health Care, St Paul, MN 55114 1000, USA
    Am J Infect Control 35:367-73. 2007
    ..One agent contained iodine povacrylex in alcohol and the second contained chlorhexidine gluconate in alcohol...
  40. ncbi Joseph Lister (1827-1912): father of antisepsis
    S Y Tan
    University of Hawaii, USA
    Singapore Med J 48:605-6. 2007
  41. ncbi Effect of correctly using alcohol-based hand rub in a clinical setting
    Sussie Laustsen
    Department of Clinical Microbiology, Aarhus University Hospital, Skejby, Brendstrupgaardsvej, Aarhus, Denmark
    Infect Control Hosp Epidemiol 29:954-6. 2008
    We evaluated hand antisepsis in clinical practice at Aarhus University Hospital in Skejby, Denmark. The rate of compliance with the correct use of alcohol-based hand rub exceeded 55% of all routine clinical procedures observed...
  42. pmc Safety of anti-infective agents for skin preparation in premature infants
    S Upadhyayula
    Rotherham General Hospital, Rotherham, UK
    Arch Dis Child 92:646-7. 2007
  43. pmc Impact of newborn skin-cleansing with chlorhexidine on neonatal mortality in southern Nepal: a community-based, cluster-randomized trial
    James M Tielsch
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Pediatrics 119:e330-40. 2007
    ..Our objective was to assess the efficacy of a 1-time skin-cleansing of newborn infants with 0.25% chlorhexidine on neonatal mortality...
  44. ncbi Prospective study to determine the penetration of iodide into the anterior chamber following preoperative application of topical 1.25% povidone-iodine
    Fabian Hansmann
    University Eye Hospital, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Graefes Arch Clin Exp Ophthalmol 245:789-93. 2007
    Povidone-iodine is currently the agent of choice for pre-operative antisepsis in ophthalmology. Due to experimental and analytical constraints, iodine absorption into the anterior chamber (AC) has not yet been studied...
  45. ncbi Antiseptics, iodine, povidone iodine and traumatic wound cleansing
    Muhammad N Khan
    General Surgery, North Hampshire Hospital NHS Trust, Basingstoke
    J Tissue Viability 16:6-10. 2006
    ..This article reviews the current literature on the use of antiseptics particularly povidine iodine in traumatic wound cleansing and discusses the beneficial and harmful effects of such practice...
  46. ncbi Comparison of bacterial counts in glove juice of surgeons wearing smooth band rings versus those without rings
    Tami R Waterman
    College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA
    Am J Infect Control 34:421-5. 2006
    ..Removal of rings is recommended before surgeons aseptically prepare for surgical procedures...
  47. ncbi Stamping out surgical site infections
    Steven Schweon
    St Luke s Hospital, Bethlehem, PA, USA
    RN 69:36-40; quiz 41. 2006
  48. ncbi Microbial contamination of antiseptics and disinfectants
    Somwang Danchaivijitr
    Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bankok
    J Med Assoc Thai 88:S133-9. 2005
    ..To study the bacterial contamination of antiseptics and disinfections in-use and the risk factors for contamination...
  49. ncbi Hand hygiene compliance: step up, reach out
    Deborah A Fry
    Lehigh Valley Hospital, Allentown, PA, USA
    Nurs Manage 37:40-3. 2006
  50. ncbi Systemic iodine absorption after preoperative antisepsis using povidone-iodine in cataract surgery-- an open controlled study
    H Below
    Institute of Hygiene and Environmental Medicine, Faculty of Medicine, Ernst Moritz Arndt University, DE 17478 Greifswald, Germany
    Dermatology 212:41-6. 2006
    After preoperative conjunctival and periorbital antisepsis with povidone-iodine (PVP-I), the systemic absorption of iodine after cataract surgery was measured to evaluate the risk of thyroid side effects...
  51. ncbi A survey of the appropriate use of antiseptic agents in the operating room of several key health care facilities. A comparison between surveys in 2000 and 2004
    T Shiraishi
    Division of Pharmacy, Yamagata University Hospital, Yamagata 990 9585, Japan
    Dermatology 212:15-20. 2006
    ..These results indicated changes in infection control measures in hospital settings after publication of the new CDC guidelines; environmental disinfection had been limited and excessive use of disinfectants reevaluated...
  52. ncbi Disposable surgical face masks: a systematic review
    Allyson Lipp
    School of Care Sciences, University of Glamorgan, UK
    Can Oper Room Nurs J 23:20-1, 24-5, 33-8. 2005
    ..Neither trial accounted for cluster randomisation in the analysis. Reviewers' conclusions: From the limited results it is unclear whether wearing surgical face masks results in any harm or benefit to the patient undergoing clean surgery...
  53. pmc Maternal and birth attendant hand washing and neonatal mortality in southern Nepal
    Victor Rhee
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Baltimore, MD 21205 2103, USA
    Arch Pediatr Adolesc Med 162:603-8. 2008
    ..More than 95% of neonatal deaths occur in developing countries, approximately 50% at home. Few data are available on the impact of hand-washing practices by birth attendants or caretakers on neonatal mortality...
  54. ncbi Efficacy of povidone-iodine in preputial antisepsis
    M Cakmak
    Department of Paediatric Surgery, Kirikkale University Medical Faculty, Kirikkale, Turkey
    Int J Clin Pract 57:752-4. 2003
    ..Surgical soap decreases the colony count, which can lead to increased effectiveness of povidone-iodine after painting. We recommend preoperative local cleaning with surgical soap before surgical painting...
  55. ncbi Wound colonization and infection: the role of topical antimicrobials
    R J White
    School of Applied Sciences, University of Wales-Institute Cardiff, Cardiff, Wales, UK
    Br J Nurs 10:563-78. 2001
    ..This review states the case for taking the antiseptic route as part of the concerted approach to local wound management and infection control...
  56. ncbi The relationship between methodological trial quality and the effects of impregnated central venous catheters
    Christine Geffers
    Department of Hospital Hygiene, Charite, Heubnerweg 6, 14059 Berlin, Germany
    Intensive Care Med 29:403-9. 2003
    ..We assessed the methodological trial quality of individual randomized controlled studies on chlorhexidine silver sulfadiazine impregnated catheters and the effect on catheter-related infection (CRI)...
  57. ncbi Prevention of nosocomial infections in the neonatal intensive care unit
    Ira Adams-Chapman
    Department of Pediatrics, Division of Neonatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Curr Opin Pediatr 14:157-64. 2002
    ..Educational programs and feedback to nursery personnel improve compliance with infection control programs...
  58. ncbi Prevention of infection in peripheral arterial reconstruction: a systematic review and meta-analysis
    Andrew H Stewart
    Department of Vascular Surgery, Gloucestershire Royal Hospital, Great Western Road, Gloucester, United Kingdom
    J Vasc Surg 46:148-55. 2007
    ..The aim of this systematic review and meta-analysis was to determine the effectiveness of perioperative strategies to prevent infection in patients undergoing peripheral arterial reconstruction...
  59. ncbi Catheter-related bloodstream infections, part II: specific pathogens and prevention
    Gianluigi Ferretti
    Division of Medical Oncology, Treviglio Hospital, Italy
    Cancer Control 10:79-91. 2003
  60. ncbi [Prevention of infections transmitted by intravascular devices (catheters, implanted sites)]
    G Nitenberg
    , Institut Gustave Roussy, 39, rue Camille Desmoulins, 94 805 Villejuif Cedex
    Rev Pneumol Clin 57:101-12. 2001
    ..Discussions concerning the real clinical efficiency, ecological risk and the cost-effectiveness of catheters impregnated with antiseptics and/or antibiotics is a perfect illustration of the current debate...
  61. ncbi Patient safety and the science of prevention: the time for implementing the Guidelines for the prevention of intravascular catheter-related infections is now
    NAOMI P O'GRADY
    Critical Care Medicine Department, Warren Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA
    Crit Care Med 31:291-2. 2003
  62. ncbi The pathogenesis of catheter-related bloodstream infection with noncuffed short-term central venous catheters
    Nasia Safdar
    Section of Infectious Diseases, Department of Medicine, Medical School, University of Wisconsin, Madison, WI 53792, USA
    Intensive Care Med 30:62-7. 2004
    ..We report a prospective study undertaken to determine the pathogenesis of CVC-related BSI...
  63. ncbi Umbilical cord care in premature infants: the effect of two different cord-care regimens (salicylic sugar powder vs chlorhexidine) on cord separation time and other outcomes
    Marco Pezzati
    Department of Critical Care Medicine, Section of Neonatology, University of Firenze School of Medicine, Firenze, Italy
    Pediatrics 112:e275. 2003
    ..To evaluate the effect of 2 cord-care regimens (salicylic sugar powder vs chlorhexidine as a 4% detergent water solution) on cord separation time and other outcomes in preterm infants...
  64. ncbi Povidone-iodine liposomes--an overview
    K Reimer
    Mundipharma GmbH, Limburg, Germany
    Dermatology 195:93-9. 1997
    ..on the eye is currently available, PVP-I has been used in ophthalmology not only for pre- and postoperative antisepsis, but also for the treatment of bacterial and viral conjunctivitis and for prophylaxis against ophthalmia ..
  65. ncbi Guideline for Prevention of Surgical Site Infection, 1999. Centers for Disease Control and Prevention (CDC) Hospital Infection Control Practices Advisory Committee
    A J Mangram
    Hospital Infections Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, USA
    Am J Infect Control 27:97-132; quiz 133-4; discussion 96. 1999
    ..g., laparoscopic cholecystectomy). Recommend specific antiseptic agents for patient preoperative skin preparations or for healthcare worker hand/forearm antisepsis. Hospitals should choose from products recommended for these activitie
  66. ncbi A randomized trial comparing povidone-iodine to a chlorhexidine gluconate-impregnated dressing for prevention of central venous catheter infections in neonates
    J S Garland
    St Joseph s Hospital, Milwaukee, WI 53210, USA
    Pediatrics 107:1431-6. 2001
    ..Neonates who require a central venous catheter (CVC) for prolonged vascular access experience high rates of catheter-related bloodstream infection (CRBSI)...
  67. ncbi Alcoholic povidone-iodine to prevent central venous catheter colonization: A randomized unit-crossover study
    Jean Jacques Parienti
    Departments of Medical Intensive Care Unit, Cote de Nacre University Hospital, Caen, France
    Crit Care Med 32:708-13. 2004
    To compare effectiveness in preventing central venous catheter colonization and infection of two protocols of cutaneous antisepsis using povidone-iodine solution in combination with ethanol or water.
  68. ncbi The role of the Doran Building in puerperal fever in Canada
    James A Low
    Department of Obstetrics and Gynaecology, Queen s University, Kingston ON, Canada
    J Obstet Gynaecol Can 29:219-27. 2007
    ..General Hospital, opened in 1894, represents an early Canadian initiative to apply the principles of sanitation, antisepsis, and asepsis to prevent puerperal fever ina freestanding lying-in hospital...
  69. ncbi Comparison of local povidone-iodine antisepsis with parenteral antibacterial prophylaxis for prevention of infective complications of TURP: a prospective randomized controlled study
    A I A Ibrahim
    College of Medicine and Medical Sciences, King Khalid University, P O Box 1544, Abha, Saudi Arabia
    Eur Urol 41:250-6. 2002
    To determine whether antisepsis with povidone-iodine solution applied at the external urethral meatus confers protection against infective complications following transurethral resection of the prostate (TURP) and compare that with ..
  70. ncbi Amniotic fluid iodine concentrations do not vary in pregnant women with varying iodine intake
    Eduardo Garcia-Fuentes
    Servicio de Endocrinologia y Nutricion, Hospital Universitario Carlos Haya, Malaga, Spain
    Br J Nutr 99:1178-81. 2008
    ..The amniocentesis was performed with abdominal antisepsis using chlorhexidine. The iodine concentration was measured in urine and amniotic fluid...
  71. ncbi Norovirus cross-contamination during food handling and interruption of virus transfer by hand antisepsis: experiments with feline calicivirus as a surrogate
    S Bidawid
    Health Canada, Food Directorate, Bureau of Microbial Hazards, Sir F G Banting Research Centre, Ross Avenue, Ottawa, Ontario, Canada K1A 0L2
    J Food Prot 67:103-9. 2004
    ..9%). These findings should help in a better assessment of the potential for cross-contamination of foods during handling and also assist in developing more effective approaches to foodborne spread of norovirus infections...
  72. pmc Office management of minor wounds
    S Gouin
    Department of Pediatrics and Division of Emergency Medicine, University of Montreal, Quebec
    Can Fam Physician 47:769-74. 2001
    ..To review office interventions for minor wounds not requiring sutures, such as abrasions, bites, and lacerations...
  73. ncbi Effect of lidocaine gel on povidone-iodine antisepsis and microbial survival
    John H Boden
    Department of Ophthalmology, Madigan Army Medical Center, Tacoma, Washington 98431, USA
    J Cataract Refract Surg 34:1773-5. 2008
    To determine whether the use of lidocaine gel prior to povidone-iodine antisepsis is associated with increased microbial survival.
  74. ncbi Master of surgery in Archiv für Klinische Chirurgie
    H G Beger
    Universitätsklinik Ulm, Steinhovelstrasse 9, Ulm, Germany
    Langenbecks Arch Surg 395:17-21. 2010
    After the routine use of ether narcosis and surgical antisepsis, the evolution of surgery experienced fascinating and genuinely surgical technique-related advancements...
  75. ncbi Pilot trial to compare tolerance of chlorhexidine gluconate to povidone-iodine antisepsis for central venous catheter placement in neonates
    J S Garland
    Department of Pediatrics, Wheaton Franciscan Health Care, St Joseph Hospital, Milwaukee, WI 53210, USA
    J Perinatol 29:808-13. 2009
    The purpose of this pilot trial was to determine whether rates of contact dermatitis following cutaneous antisepsis for central catheter placement were similar among neonates treated with chlorhexidine gluconate and povidone-iodine...
  76. ncbi Treatment of head injuries in the American Civil War
    H H Kaufman
    Department of Neurosurgery, West Virginia University School of Medicine, Morgantown
    J Neurosurg 78:838-45. 1993
    ..Almost immediately after the war, increased knowledge about cerebral localization and the development of antisepsis (and then asepsis) permitted the development of modern neurosurgery.
  77. ncbi Prevention of infection in arterial reconstruction
    A Stewart
    Dolphin House, Department of Vascular Surgery, Bristol Royal Infirmary, Bristol, UK BS2 8HW
    Cochrane Database Syst Rev 3:CD003073. 2006
    ..Arterial reconstructions with prosthetic graft materials or vein are susceptible to infection with a resultant high patient mortality and risk of limb loss. To reduce the risk of infection effective perioperative measures are essential...
  78. ncbi Tacky but refined: a "slick" technique for dressings that hold better
    P R Carrington
    Carrington Dermatology, Rogers, Arkansas 72756, USA
    Dermatol Surg 26:929-30. 2000
    ..to the patient (and surgeon) and, at the same time, functions to decrease seroma or hematoma formation, enhances antisepsis by blocking transient bacterial contamination, and inhibits traumatic sabotage of surgical wounds due to patient ..
  79. ncbi The effect of povidone iodine flush versus drops on conjunctival colonization before intravitreal injections
    Ammar Safar
    Department of Ophthalmology, Jones Eye Institute, University of Arkansas for Medical Sciences, 4301 West Markham, Slot 523, Little Rock, AR 72205, USA
    Int Ophthalmol 27:307-12. 2007
    ..To determine the most effective method of applying povidone iodine 5% to decrease conjunctival colonization before intravitreal injections...
  80. ncbi Comparative testing of liposomal and aqueous formulations of povidone-iodine for their angioirritative potential at the chorioallantoic membrane of ex ovo cultivated chick embryos
    P Wutzler
    Institute for Virology and Antiviral Therapy, Friedrich Schiller University, Jena, Germany
    Dermatology 207:43-7. 2003
    ..microbicidal activity, povidone-iodine (PVP-I) is used for local anti-infective treatment, especially for wound antisepsis of the skin...
  81. ncbi Antibiotic prophylaxis: is it needed for dialysis access procedures?
    Loay Salman
    Section of Interventional Nephrology, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, Miami, FL 33136, USA
    Semin Dial 22:297-9. 2009
    ..Povidone iodine was used for skin antisepsis in all cases. One patient (0.04%) postangioplasty and one patient (0...
  82. pmc Efficacy of two ethanol-based skin antiseptics on the forehead at shorter application times
    Gunter Kampf
    Bode Chemie GmbH and Co, KG, Scientific Affairs, Melanchthonstrasse 27, 22525 Hamburg, Germany
    BMC Microbiol 7:85. 2007
    ..Colonies were counted after incubation of plates at 36 degrees C for 48 h. The mean log10 reduction of bacteria was calculated. The Wilcoxon matched-pairs signed-ranks test was used for a comparison of treatments...
  83. ncbi [Pott triad and Schmorl nodules. A historical overview of kyphosis with special reference to tuberculous spondylitis and Scheuermann disease]
    M A Rauschmann
    Orthopädische Universitätsklinik Stiftung Friedrichsheim, Marienburgstrasse 2, 60528 Frankfurt M
    Orthopade 30:903-14. 2001
    ..opinion leaders at the beginning of the century and the influence of new techniques and developments (asepsis, antisepsis, anesthesia, bacteriology, X-ray, antibiotics) on the differential diagnosis and therapy...
  84. ncbi Reproducibility and workability of the European test standard EN 12791 regarding the effectiveness of surgical hand antiseptics: a randomized, multicenter trial
    Manfred Rotter
    Institute of Hygiene and Medical Microbiology, Medical University, Vienna, Austria
    Infect Control Hosp Epidemiol 27:935-9. 2006
    ....
  85. ncbi Comparison of povidone iodine and DuraPrep, an iodophor-in-isopropyl alcohol solution, for skin disinfection prior to epidural catheter insertion in parturients
    David J Birnbach
    Departments of Anesthesiology and Obstetrics and Gynecology, University of Miami School of Medicine, Florida 33136, USA
    Anesthesiology 98:164-9. 2003
    ..The purpose of this study was to evaluate the antisepsis achieved with DuraPrep compared with povidone iodine (PI).
  86. ncbi Children as guinea pigs: historical perspective
    Susan E Lederer
    Yale University, School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Account Res 10:1-16. 2003
    ..trial of cowpox vaccine, the first human trial of rabies vaccine, and the first treatment of Listerian wound antisepsis. The history of concern for children, especially institutionalized children, in medical research is considered ..
  87. ncbi On the surgical treatment of facial paralysis in the early nineteenth century
    Robert C van de Graaf
    Department of Plastic Surgery, University Medical Center Groningen, The Netherlands
    Plast Reconstr Surg 121:475-80. 2008
    ..They performed their operations at a time when anesthesia, asepsis, antisepsis, and antibiotics had not yet been introduced into surgery...
  88. ncbi Perioperative management of neurosurgical patients with methicillin-resistant Staphylococcus aureus
    Paul T Akins
    Department of Neurosurgery, Kaiser Permanente, Sacramento, California 95825, USA
    J Neurosurg 112:354-61. 2010
    ..The authors investigated the impact of MRSA colonization and infection in the neurosurgical population at a community-based, tertiary care referral center...
  89. ncbi Guideline for Hand Hygiene in Health-Care Settings: recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force
    John M Boyce
    Hospital of Saint Raphael, New Haven, Connecticut, USA
    Infect Control Hosp Epidemiol 23:S3-40. 2002
    ..in Health-Care Settings provides health-care workers (HCWs) with a review of data regarding handwashing and hand antisepsis in health-care settings...
  90. ncbi Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HIPAC/SHEA/APIC/IDSA Hand Hygiene Task Force
    John M Boyce
    Hospital of Saint Raphael, New Haven
    Am J Infect Control 30:S1-46. 2002
    ..in Health-Care Settings provides health-care workers (HCWs) with a review of data regarding handwashing and hand antisepsis in health-care settings...
  91. ncbi Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America/Association for Prof
    John M Boyce
    Hospital of Saint Raphael, New Haven, Connecticut, USA
    MMWR Recomm Rep 51:1-45, quiz CE1-4. 2002
    ..in Health-Care Settings provides health-care workers (HCWs) with a review of data regarding handwashing and hand antisepsis in health-care settings...
  92. ncbi [The advantage of preventive vaginal antisepsis with hexetidine in obstetrics and gynecology]
    H Weidinger
    Frauenklinik, Klinikum Bayreuth
    Geburtshilfe Frauenheilkd 51:929-35. 1991
    ..The new hexetidine preparation appeared to be efficient in vaginal antisepsis, especially in pregnancy. A favourable lactobacilli-selective effect was demonstrated...
  93. ncbi Spinal-injured neuropathic bladder antisepsis (SINBA) trial
    B B Lee
    Spinal Medicine Department, Prince of Wales Hospital, Sydney, New South Wales, Australia
    Spinal Cord 45:542-50. 2007
    ..To determine whether Methenamine Hippurate (MH) or cranberry tablets prevent urinary tract infections (UTI) in people with neuropathic bladder following spinal cord injury (SCI)...
  94. ncbi Clinical study on the antiseptic effect of povidone-iodine solution for the surgical field of digestive tract operations
    K Shindo
    Department of Surgery, Kinki University School of Medicine, Sakai Hospital, Osaka, Japan
    Dermatology 204:47-51. 2002
    Our previous study showed 10% povidone-iodine solution (Isodine) to be safe and effective for skin antisepsis in healthy young adults...
  95. ncbi Evidence-based nursing practice to prevent infection in hospitalized neutropenic patients with cancer
    Elaine Larson
    School of Nursing, Columbia University in New York, NY, USA
    Oncol Nurs Forum 31:717-25. 2004
    ..To review studies that have assessed the effectiveness of selected nursing interventions used in hospitals to prevent healthcare-associated infections in neutropenic patients with cancer...
  96. ncbi [Practice assessment of central venous lines care in surgical ICU of French university hospitals]
    O Mimoz
    EA3809 INSERM, ERI 23, Service d Anesthesie Reanimation, CHU de Poitiers, Universite de Poitiers, 1 rue de la milétrie, Poitiers Cedex, France
    Ann Fr Anesth Reanim 29:104-12. 2010
    ..The aim of this study was to estimate their knowledge and/or application by physicians in French university hospital ICUs...
  97. ncbi Bacterial contamination of the hands of hospital staff during routine patient care
    D Pittet
    Department of Internal Medicine, University of Geneva Hospitals
    Arch Intern Med 159:821-6. 1999
    ..Cross-transmission of microorganisms by the hands of health care workers is considered the main route of spread of nosocomial infections...
  98. ncbi British contributions to modern herniology of the groin
    R C Read
    University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Hernia 9:6-11. 2005
    ..Retzius' space (Edinburgh, 1858) with Lister's antisepsis (1865) enabled preperitoneal herniorrhaphy (Annandale, 1876)...
  99. ncbi MRSA patients: proven methods to treat colonization and infection
    J M Boyce
    Division of Infectious Diseases, Hospital of Saint Raphael, New Haven, CT 06511, USA
    J Hosp Infect 48:S9-14. 2001
    ..placing colonized and infected patients in isolation, use of barrier precautions and handwashing and hand antisepsis. Culturing hospitalized patients at high risk of acquiring MRSA can facilitate detection and isolation of ..
  100. ncbi Antimicrobial effectiveness of povidone-iodine and consequences for new application areas
    K Reimer
    Mundipharma GmbH, Limburg, Deutschland
    Dermatology 204:114-20. 2002
    ..Hence alongside the classical fields of application, such as the disinfection of the skin and hands, mucosa antisepsis and wound treatment, there are also useful indications for the substance, i.e...
  101. pmc Sutureless prepuceplasty with wound healing by second intention: an alternative surgical approach in children's phimosis treatment
    Efstratios Christianakis
    Department of Pediatric Surgery, Pendeli Children s Hospital, Palaia Pendeli, Athens, Greece
    BMC Urol 8:6. 2008
    ..A new technique for the treatment of children's phimosis is presented that minimizes the repairing time, the postoperative complications and maintains the physical foreskin appearance intact...

Research Grants21

  1. BALTIMORE PEDIATRIC EYE SURVEY
    James Tielsch; Fiscal Year: 2007
    ..The analysis will focus on estimating the age and race-specific prevalence of ocular disorders in this group and on assessing the association of selected risk factors with the prevalence of these disorders. ..
  2. Validation of extracellular histones as biomarker and therapeutic target in sepsi
    FLOREA contact LUPU; Fiscal Year: 2010
    ..that correlates with clinical outcomes, and helps to identify the patients who will benefit from specific antisepsis therapies with histone blockade...
  3. Small Molecules to Enhance Bacterial Susceptibility to Antiseptics
    ANGELA MARIE POLLARD; Fiscal Year: 2012
    ..activity of the CHG active ingredient in antiseptics using in vitro assays designed to mimic pre-operative antisepsis conditions...
  4. Infections in Patients treated with Dialysis: Incidence, Risk Factors and Outcome
    Seth Wright; Fiscal Year: 2013
    ..the impact of facility size, staffing ratios, and prevention strategies such as vaccination prevalence, skin antisepsis type, and catheter locking solutions)...
  5. Randomized Trial/Reduce Recurrence/Bacterial Vaginosis
    King Holmes; Fiscal Year: 2004
    ..genital hygiene in men represents an important risk factor for BV, and that improved male genital hygiene or antisepsis, especially among uncircumcised men, and/or antibiotic treatment of the male partners with broad-spectrum ..
  6. Novel Topical Treatment of Eczema
    Bakul Bhatt; Fiscal Year: 2006
    ..3%-72.9%) as a consequence to frequent hand washing, antisepsis techniques, and chronic occlusion from gloving...
  7. Chemical and Biological Studies on Biaryl Phenolics
    Ken Feldman; Fiscal Year: 2005
    Continuing biological evaluation of potential anticancer and antisepsis chemotherapeutic analogues of members of the hydrolyzable tannin family of secondary plant metabolites is proposed...
  8. Biofilm Prevention and Treatment Device
    Steven Frank; Fiscal Year: 2003
    ..This study proposes an active, iontophoretic, delivery system - Active Antisepsis (AA) - that electronically controls the dose and penetration of silver ions surrounding a treated medical device...
  9. Incidence, risk factors, and consequences of neonatal hypothermia in Nepal
    LUKE MULLANY; Fiscal Year: 2008
    ..Examination of alternate cutoffs for defining hypothermia severity may improve design of low-cost technologies for identification and subsequent management of hypothermic infants in the community. [unreadable] [unreadable] [unreadable]..
  10. ZINC SUPPLEMENTATION IMPACT ON CHILD MORTALITY--NEPAL
    James Tielsch; Fiscal Year: 2003
    ..The analysis will focus on comparison of rates of mortality and morbidity between treatment groups with additional analyses of subgroups to look for interaction by age, gender or baseline nutritional status. ..
  11. Catheter Dwell Time and Risk of Bloodstream Infections in Hospitalized Neonates
    Aaron M Milstone; Fiscal Year: 2011
    ..This project will help to develop evidence-based strategies to prevent bloodstream infections among vulnerable infants hospitalized in the neonatal intensive care unit. ..
  12. Staff Hand Hygiene and Nosocomial Infections in Neonates
    Elaine Larson; Fiscal Year: 2003
    ....
  13. Stopping URIs and FLU in the Family: the Stuffy Trial
    Elaine Larson; Fiscal Year: 2008
    ....
  14. Discharge Planning and Telehealth for Post CABG Elders
    Ruth Kleinpell; Fiscal Year: 2009
    ....
  15. HOME HYGIENE INTERVENTION
    Elaine Larson; Fiscal Year: 2002
    ..Logistic regression, Liang-Zeger regression, and Chi Square analyses will be used to test differences in rates of transmission of symptoms and changes in quantity, types and resistance patterns of microbial flora of the hands. ..
  16. Electrophysiology Of Avian Brainstem Topography
    David Harris; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Interdisciplinary Research:Antimicrobial Resistance(RMI)
    Elaine Larson; Fiscal Year: 2006
    ..In the final year, plans for a sustainable Consortium on antimicrobial resistance will be formalized. [unreadable] [unreadable]..
  18. Antimicrobial Laser
    David Harris; Fiscal Year: 2005
    ..pathogens described in this application will enable the design of a novel laser system optimized for root antisepsis. Phase I: Six-month feasibility study: Develop a quantitative, predictive model...
  19. Impact of Hand Hygiene Guideline on Infections and Costs
    Elaine Larson; Fiscal Year: 2005
    ..abstract_text> ..
  20. Newborn Antiseptic Washing and Neonatal Mortality-Nepal
    James Tielsch; Fiscal Year: 2005
    ..The umbilical cord infection trial will require only one year of recruitment to obtain adequate numbers to detect a 20% in infection rates in the treatment groups. ..
  21. Anti-Selectin Blocker for Liver Ischemic Injury
    LUIS TOLEDO PEREYRA; Fiscal Year: 2006
    ..Treatment with TCB-1269 will enhance the quality of life of millions of patients suffering from the large number of maladies associated with ischemia/reperfusion ischemic maladies. [unreadable] [unreadable]..