maternal exposure

Summary

Summary: Exposure of the female parent, human or animal, to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals that may affect offspring. It includes pre-conception maternal exposure.

Top Publications

  1. pmc Prenatal phenol and phthalate exposures and birth outcomes
    Mary S Wolff
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 116:1092-7. 2008
  2. ncbi Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Endocrinology 147:5515-23. 2006
  3. pmc Maternal high-fat diet effects on third-generation female body size via the paternal lineage
    Gregory A Dunn
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6046, USA
    Endocrinology 152:2228-36. 2011
  4. ncbi The Danish National Birth Cohort--its background, structure and aim
    J Olsen
    Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    Scand J Public Health 29:300-7. 2001
  5. ncbi Arsenic exposure during pregnancy and size at birth: a prospective cohort study in Bangladesh
    Anisur Rahman
    International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka, Bangladesh
    Am J Epidemiol 169:304-12. 2009
  6. pmc Maternal exposure to particulate air pollution and term birth weight: a multi-country evaluation of effect and heterogeneity
    Payam Dadvand
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Health Perspect 121:267-373. 2013
  7. ncbi Pain reactivity in 2-month-old infants after prenatal and postnatal serotonin reuptake inhibitor medication exposure
    Tim F Oberlander
    Department of Pediatrics, Biobehavioral Research Unit, Centre for Community Child Health Research, Room L408, 4480 Oak St, Vancouver, BC, Canada
    Pediatrics 115:411-25. 2005
  8. pmc Variability and predictors of urinary bisphenol A concentrations during pregnancy
    Joe M Braun
    Department of Environmental Health, Harvard University, Boston, Massachusetts, USA
    Environ Health Perspect 119:131-7. 2011
  9. pmc Oral exposure to bisphenol a increases dimethylbenzanthracene-induced mammary cancer in rats
    Sarah Jenkins
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Environ Health Perspect 117:910-5. 2009
  10. pmc Influence of prenatal lead exposure on genomic methylation of cord blood DNA
    J Richard Pilsner
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Environ Health Perspect 117:1466-71. 2009

Detail Information

Publications334 found, 100 shown here

  1. pmc Prenatal phenol and phthalate exposures and birth outcomes
    Mary S Wolff
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 116:1092-7. 2008
    ..Many phthalates and phenols are hormonally active and are suspected to alter the course of development...
  2. ncbi Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease
    Matthew D Anway
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4231, USA
    Endocrinology 147:5515-23. 2006
    ..The observations demonstrate that an environmental compound, endocrine disruptor, can induce transgenerational disease states or abnormalities, and this suggests a potential epigenetic etiology and molecular basis of adult onset disease...
  3. pmc Maternal high-fat diet effects on third-generation female body size via the paternal lineage
    Gregory A Dunn
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6046, USA
    Endocrinology 152:2228-36. 2011
    ....
  4. ncbi The Danish National Birth Cohort--its background, structure and aim
    J Olsen
    Danish Epidemiology Science Centre, Statens Serum Institut, Copenhagen, Denmark
    Scand J Public Health 29:300-7. 2001
    ..By August 2000. a total of 60,000 pregnant women had been recruited to the study. It is expected that a large number of gene-environmental hypotheses need to be based on case-control analyses within a cohort like this...
  5. ncbi Arsenic exposure during pregnancy and size at birth: a prospective cohort study in Bangladesh
    Anisur Rahman
    International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka, Bangladesh
    Am J Epidemiol 169:304-12. 2009
    ..14 (SE, 0.03) mm per 1 microg/L, respectively. No further negative effects were shown at higher levels of arsenic exposure. The indicated negative effect on birth size at a low level of arsenic exposure warrants further investigation...
  6. pmc Maternal exposure to particulate air pollution and term birth weight: a multi-country evaluation of effect and heterogeneity
    Payam Dadvand
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Health Perspect 121:267-373. 2013
    A growing body of evidence has associated maternal exposure to air pollution with adverse effects on fetal growth; however, the existing literature is inconsistent.
  7. ncbi Pain reactivity in 2-month-old infants after prenatal and postnatal serotonin reuptake inhibitor medication exposure
    Tim F Oberlander
    Department of Pediatrics, Biobehavioral Research Unit, Centre for Community Child Health Research, Room L408, 4480 Oak St, Vancouver, BC, Canada
    Pediatrics 115:411-25. 2005
    ..Based on previous findings showing reduced pain responses in newborns after prenatal exposure, we hypothesized that altered pain reactivity would also be found at 2 months of age...
  8. pmc Variability and predictors of urinary bisphenol A concentrations during pregnancy
    Joe M Braun
    Department of Environmental Health, Harvard University, Boston, Massachusetts, USA
    Environ Health Perspect 119:131-7. 2011
    ..Prenatal bisphenol A (BPA) exposure may be associated with developmental toxicity, but few studies have examined the variability and predictors of urinary BPA concentrations during pregnancy...
  9. pmc Oral exposure to bisphenol a increases dimethylbenzanthracene-induced mammary cancer in rats
    Sarah Jenkins
    Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Environ Health Perspect 117:910-5. 2009
    ..Bisphenol A (BPA) is widely used in the manufacture of polycarbonate plastics, including infant formula bottles...
  10. pmc Influence of prenatal lead exposure on genomic methylation of cord blood DNA
    J Richard Pilsner
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
    Environ Health Perspect 117:1466-71. 2009
    ..Epigenetic fetal programming via DNA methylation may provide a pathway by which environmental lead exposure can influence disease susceptibility...
  11. ncbi Ambient air pollution and preterm birth in the environment and pregnancy outcomes study at the University of California, Los Angeles
    Beate Ritz
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095, USA
    Am J Epidemiol 166:1045-52. 2007
    ..These results confirm the importance of reducing exposure misclassification when evaluating the effect of traffic-related pollutants that vary spatially...
  12. pmc Association of prenatal exposure to polybrominated diphenyl ethers and infant birth weight
    Kim G Harley
    Center for Environmental Research and Children s Health, School of Public Health, University of California, Berkeley, Berkeley, CA 94704, USA
    Am J Epidemiol 174:885-92. 2011
    ..These findings were diminished slightly and were no longer statistically significant when maternal weight gain was included in the models. PBDE congeners were not associated with birth length, head circumference, or gestational duration...
  13. ncbi Effects of exposure to selective serotonin reuptake inhibitors during pregnancy on serotonergic symptoms in newborns and cord blood monoamine and prolactin concentrations
    Kari Laine
    Department of Pharmacology and Clinical Pharmacology, University of Turku and Turku University Central Hospital, Turku, Finland
    Arch Gen Psychiatry 60:720-6. 2003
    ..We aimed to investigate the perinatal sequelae of infants exposed to SSRIs during their fetal life and the relationship of these symptoms to the cord blood monoamine and prolactin concentrations...
  14. pmc Association of childhood obesity with maternal exposure to ambient air polycyclic aromatic hydrocarbons during pregnancy
    Andrew Rundle
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Am J Epidemiol 175:1163-72. 2012
    ..59), a 1.93-unit higher percentage of body fat (95% CI: 0.33, 3.54), and a relative risk of 2.26 (95% CI: 1.28, 4.00) for obesity at age 7 years. The data indicate that prenatal exposure to PAHs is associated with obesity in childhood...
  15. pmc Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy
    Helle R Andersen
    Institute of Public Health, Department of Environmental Medicine, University of Southern Denmark, Odense, Denmark
    Environ Health Perspect 116:566-72. 2008
    ..The aim of this prospective study was to investigate whether occupational pesticide exposure during pregnancy causes adverse effects on the reproductive development in the male infants...
  16. pmc Ambient air pollution and low birth weight in Connecticut and Massachusetts
    Michelle L Bell
    School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut 06511, USA
    Environ Health Perspect 115:1118-24. 2007
    ..Several studies have examined whether air pollution affects birth weight; however results vary and many studies were focused on Southern California or were conducted outside of the United States...
  17. pmc Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California
    Jun Wu
    Program in Public Health, College of Health Sciences, University of California, Irvine, California 92697 7555, USA
    Environ Health Perspect 117:1773-9. 2009
    ..Increasing evidence suggests that air pollution adversely affects pregnancy outcomes. Yet few studies have examined how local traffic-generated emissions affect preeclampsia in addition to preterm birth...
  18. pmc Partition of environmental chemicals between maternal and fetal blood and tissues
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 45:1121-6. 2011
    ..Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform...
  19. ncbi Air pollution and birth outcomes: a systematic review
    Prakesh S Shah
    Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada
    Environ Int 37:498-516. 2011
    ....
  20. ncbi Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring
    Alan S Brown
    New York State Psychiatric Institute, 1051 Riverside Dr, Unit 23, New York, NY 10032, USA
    Am J Psychiatry 162:767-73. 2005
    ..The authors examined the relationship between maternal antibody to toxoplasmosis and the risk of schizophrenia and other schizophrenia spectrum disorders in offspring. Toxoplasmosis is known to adversely affect fetal brain development...
  21. pmc A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute of medicine criteria
    H Eugene Hoyme
    Department of Pediatrics, Division of Medical Genetics, H 315, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    Pediatrics 115:39-47. 2005
    ..Although both approaches have improved the clinical delineation of FASD, both suffer from significant drawbacks in their practical application in pediatric practice...
  22. pmc Prenatal insecticide exposures and birth weight and length among an urban minority cohort
    Robin M Whyatt
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 112:1125-32. 2004
    ..Findings support recent regulatory action to phase out residential uses of the insecticides...
  23. pmc Ambient air pollution and adverse birth outcomes: methodologic issues in an emerging field
    Beate Ritz
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    Basic Clin Pharmacol Toxicol 102:182-90. 2008
    ..Investigating biological mechanisms (e.g. using ultrasound measurements and biomarkers for hypothesized pathways) is an important remaining issue...
  24. pmc Maternal cadmium exposure during pregnancy and size at birth: a prospective cohort study
    Maria Kippler
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 120:284-9. 2012
    ..Cadmium (Cd) is an embryotoxic and teratogenic metal in a variety of animal species, but data from humans are limited...
  25. ncbi Environmental exposures and adverse pregnancy outcomes: a review of the science
    Karen Perry Stillerman
    Physicians for Social Responsibility
    Reprod Sci 15:631-50. 2008
    ..Further research, education, and improved public health policy are needed to reduce potentially adverse exposures...
  26. pmc Fetal lead exposure at each stage of pregnancy as a predictor of infant mental development
    Howard Hu
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:1730-5. 2006
    ..The impact of prenatal lead exposure on neurodevelopment remains unclear in terms of consistency, the trimester of greatest vulnerability, and the best method for estimating fetal lead exposure...
  27. ncbi Analysis of hemoglobin adducts from acrylamide, glycidamide, and ethylene oxide in paired mother/cord blood samples from Denmark
    Hans von Stedingk
    Department of Materials and Environmental Chemistry, Environmental Chemistry Unit, Arrhenius Laboratory, Stockholm University, SE 106 91 Stockholm, Sweden
    Chem Res Toxicol 24:1957-65. 2011
    The knowledge about fetal exposure to acrylamide/glycidamide from the maternal exposure through food is limited...
  28. ncbi Human maternal and umbilical cord blood concentrations of polybrominated diphenyl ethers
    Warren G Foster
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Chemosphere 84:1301-9. 2011
    ....
  29. ncbi Perception of risk regarding the use of medications and other exposures during pregnancy
    Hedvig Nordeng
    Department of Pharmacy, School of Pharmacy, University of Oslo, Oslo, Norway
    Eur J Clin Pharmacol 66:207-14. 2010
    ..Perception of risk may impact a woman's decision to take a needed drug during pregnancy. There is a paucity of research on this topic in the literature...
  30. ncbi Serum vaccine antibody concentrations in children exposed to perfluorinated compounds
    Philippe Grandjean
    Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, EOME 3E 110, Boston, MA 02215, USA
    JAMA 307:391-7. 2012
    ..They cause immune suppression in a rodent model at serum concentrations similar to those occurring in the US population, but adverse health effects of PFC exposure are poorly understood...
  31. ncbi Maternal use of nicotine replacement therapy during pregnancy and offspring birthweight: a study within the Danish National Birth Cohort
    Tina H Lassen
    National Institute of Public Health, University of Southern Denmark, Copenhagen K, Denmark
    Paediatr Perinat Epidemiol 24:272-81. 2010
    ..The results of this study suggest that maternal use of NRT in pregnancy does not seriously affect birthweight, but there could be a negative effect on birthweight associated with simultaneous use of more than one type of NRT product...
  32. pmc Relation between cord blood mercury levels and early child development in a World Trade Center cohort
    Sally Ann Lederman
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 116:1085-91. 2008
    ..This study was designed to determine whether prenatal mercury exposure, including potential releases from the World Trade Center (WTC) disaster, adversely affects fetal growth and child development...
  33. pmc Maternal smoking, GSTM1 and GSTT1 polymorphism and susceptibility to adverse pregnancy outcomes
    Regina Grazuleviciene
    Vytautas Magnus University, K Donelaicio g 58, LT 44248, Kaunas, Lithuania
    Int J Environ Res Public Health 6:1282-97. 2009
    ....
  34. ncbi Perinatal lead and mercury exposure in Austria
    Claudia Gundacker
    Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090 Vienna, Austria
    Sci Total Environ 408:5744-9. 2010
    ..We aimed to compare perinatal Pb and Hg concentrations and to explore the potential association between Pb and Hg exposure and newborn anthropometry...
  35. pmc Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring
    Svetlana I Novikova
    Laboratory of Neurogenomics and Proteomics, Department of Biomedical Sciences, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 3:e1919. 2008
    ....
  36. ncbi Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study
    Linda Hanssen
    Department of Community Medicine, University of Tromsø, 9037 Tromsø, Norway
    J Environ Monit 12:1355-61. 2010
    ..Possible exposure pathways could be different from those elucidated in the western world with the exception of the urban community in our study that showed higher living standards in general and easier access to modern consumer products...
  37. pmc Air pollution exposure during pregnancy, ultrasound measures of fetal growth, and adverse birth outcomes: a prospective cohort study
    Edith H van den Hooven
    Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health Perspect 120:150-6. 2012
    ..Air pollution exposure during pregnancy might have trimester-specific effects on fetal growth...
  38. pmc Maternal personal exposure to airborne benzene and intrauterine growth
    Remy Slama
    INSERM, Institut National de la Sante et de la Recherche Medicale, University J Fourier Grenoble, Avenir Team Environmental Epidemiology Applied to Fecundity and Reproduction, U823, Institut Albert Bonniot, Grenoble, France
    Environ Health Perspect 117:1313-21. 2009
    ..Studies relying on outdoor pollutants measures have reported associations between air pollutants and birth weight...
  39. ncbi Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight
    Xiaobin Wang
    Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, 91 E Concord St, Maternity 4, Boston, MA 02118, USA
    JAMA 287:195-202. 2002
    ..Little is known about genetic susceptibility to cigarette smoke in relation to adverse pregnancy outcomes...
  40. ncbi Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life
    Erin P Hines
    U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Mol Cell Endocrinol 304:97-105. 2009
    ..01mg PFOA/kg BW. The mode of action of these effects and its relevance to human health remain to be explored...
  41. pmc Maternal smoking during pregnancy and child outcomes: real or spurious effect?
    Valerie S Knopik
    Department of Community Health, Center for Alcohol and Addiction Studies, Brown University, Providence, Rhode Island 02912, USA
    Dev Neuropsychol 34:1-36. 2009
    ..Carefully designed studies using genetically sensitive strategies can build on current evidence and begin to elucidate the likely complex factors contributing to associations between MSDP and child outcomes...
  42. pmc Intrauterine exposure to environmental pollutants and body mass index during the first 3 years of life
    Stijn L Verhulst
    Department of Pediatrics, University of Antwerp, Antwerp, Belgium
    Environ Health Perspect 117:122-6. 2009
    ..We investigated the association between body mass index (BMI) standard deviation score (SDS) and prenatal exposure to hexachlorobenzene, dichlorodiphenyldichloroethylene (DDE), dioxin-like compounds, and polychlorinated biphenyls (PCBs)...
  43. ncbi Self-reported nicotine exposure and plasma levels of cotinine in early and late pregnancy
    Lena George
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Acta Obstet Gynecol Scand 85:1331-7. 2006
    ..This study aimed to validate self-reported smoking, smoking cessation, and environmental tobacco smoke exposure in early and late pregnancy, using the biomarker cotinine as the gold standard...
  44. pmc Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth
    Noriaki Washino
    Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Environ Health Perspect 117:660-7. 2009
    ..Although recent studies have shown that these chemicals interfere with fetal growth in humans, the results are inconsistent...
  45. pmc Effects of prenatal exposure to surface-coated nanosized titanium dioxide (UV-Titan). A study in mice
    Karin S Hougaard
    National Research Centre for the Working Environment, Copenhagen Ø, Denmark
    Part Fibre Toxicol 7:16. 2010
    ..Consequently, also toxicological properties may change compared to the parent compound. We examined developmental and neurobehavioral effects following maternal exposure to a nanoparticulate UV-filter (UV-titan L181).
  46. ncbi Maternal levels of perfluorinated chemicals and subfecundity
    Chunyuan Fei
    Department of Epidemiology, School of Public Health, University of California Los Angeles, PO Box 951772, 71 254 CHS, 650 Charles E Young Drive South, Los Angeles, CA 90095 1772, USA
    Hum Reprod 24:1200-5. 2009
    ..Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are ubiquitous man-made compounds that are possible hormonal disruptors. We examined whether exposure to these compounds may decrease fecundity in humans...
  47. ncbi Fetal exposure to phthalates--a pilot study
    Matthias Wittassek
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstr 25 29, 91054 Erlangen, Germany
    Int J Hyg Environ Health 212:492-8. 2009
    ..Due to the continuous turn over of AF, urinary levels may be most appropriate for assessing both maternal and fetal phthalate exposure...
  48. pmc Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers
    Rebecca C Fry
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Genet 3:e207. 2007
    ..These studies clearly demonstrate the robust impact of a mother's arsenic consumption on fetal gene expression as evidenced by transcript levels in newborn cord blood...
  49. ncbi Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort
    Stephanie M Engel
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Epidemiol 165:1397-404. 2007
    ..The authors uncovered additional evidence that prenatal levels of organophosphate pesticide metabolites are associated with anomalies in primitive reflexes, which are a critical marker of neurologic integrity...
  50. ncbi The risk of adverse reproductive and developmental disorders due to occupational pesticide exposure: an overview of current epidemiological evidence
    Wojciech Hanke
    Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland
    Int J Occup Med Environ Health 17:223-43. 2004
    ..In the light of existing although still limited evidence of adverse effects of pesticide exposure on fertility during the preconceptual period, it is necessary to reduce the exposure to pesticides...
  51. ncbi Polish mother and child cohort study--defining the problem, the aim of the study and methodological assumption
    Kinga Polanska
    Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Łódź, Poland
    Int J Occup Med Environ Health 22:383-91. 2009
    ....
  52. ncbi Developmental thyroid hormone disruption: prevalence, environmental contaminants and neurodevelopmental consequences
    Mary E Gilbert
    Toxicity Assessment Division MD B105 05, US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Neurotoxicology 33:842-52. 2012
    ..Additional work is required to understand the impact of low level perturbations of the thyroid axis to evaluate the risk associated with environmental contaminants with thyroid action...
  53. pmc Maternal exposure to air pollution and birth outcomes
    Ebba Malmqvist
    Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden
    Environ Health Perspect 119:553-8. 2011
    ..The knowledge about air pollution effects on birth weight, prematurity, and small for gestational age (SGA) in low-exposure areas is insufficient...
  54. pmc Lower birth weight and increased body fat at school age in children prenatally exposed to modern pesticides: a prospective study
    Christine Wohlfahrt-Veje
    University Dept, of Growth and Reproduction, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Environ Health 10:79. 2011
    ..The purpose of this study was to assess possible effects of prenatal exposure to currently used pesticides on children's growth, endocrine and reproductive function...
  55. ncbi Environmental tobacco smoke and fetal health: systematic review and meta-analysis
    J Leonardi-Bee
    Dr J Leonardi Bee, Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, Nottingham NG5 1PB, UK
    Arch Dis Child Fetal Neonatal Ed 93:F351-61. 2008
    ..To determine the effects of environmental tobacco smoke (ETS) exposure on birth outcomes...
  56. ncbi Maternal exposure to ambient air pollutants and risk of congenital anomalies
    Judith Rankin
    Institute of Health and Society, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Environ Res 109:181-7. 2009
    Studies have suggested an association between maternal exposure to ambient air pollution and risk of congenital anomaly...
  57. ncbi Maternal exposure to low-level heavy metals during pregnancy and birth size
    Sayaka Shirai
    Department of Environmental Studies, University of Tokyo, Kashiwanoha, Kashiwa, Chiba, Japan
    J Environ Sci Health A Tox Hazard Subst Environ Eng 45:1468-74. 2010
    ..For HC, Sn was selected with a negative beta. The present study suggested that even a low-level Cd body burden of general population has slight but significant negative effect on BW...
  58. pmc Associations of prenatal exposure to organophosphate pesticide metabolites with gestational age and birth weight
    Stephen A Rauch
    Child and Family Research Institute, BC Children s Hospital, Vancouver, British Columbia, Canada
    Environ Health Perspect 120:1055-60. 2012
    ..Single nucleotide polymorphisms in paroxanase (PON1) enzyme genotypes may modify the relationships between OP exposure and perinatal outcomes...
  59. pmc Maternal exposure to polycyclic aromatic hydrocarbons and 5'-CpG methylation of interferon-γ in cord white blood cells
    Wan Yee Tang
    Division of Environmental Genetics and Molecular Toxicology, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    Environ Health Perspect 120:1195-200. 2012
    ..However, it has yet to be established whether maternal exposure to polycyclic aromatic hydrocarbons (PAHs) can alter these gene promoters epigenetically during fetal ..
  60. pmc Association between biomass fuel use and maternal report of child size at birth--an analysis of 2005-06 India Demographic Health Survey data
    Chandrashekhar T Sreeramareddy
    Department of Community Medicine, Melaka Manipal Medical College, Jalan Batu Hampar, Bukit Baru, Melaka, Malaysia
    BMC Public Health 11:403. 2011
    Observational epidemiological studies and a systematic review have consistently shown an association between maternal exposure to biomass smoke and reduced birth weight. Our aim was to further test this hypothesis.
  61. ncbi Prenatal exposure to lead in Spain: cord blood levels and associated factors
    Sabrina Llop
    Centre of Public Health Research, Av Catalunya 21, 46020, Valencia, Spain
    Sci Total Environ 409:2298-305. 2011
    ..The present research was carried out within the framework of the INMA project INfancia y Medio Ambiente (Environment and Childhood)...
  62. pmc Cryptorchidism and maternal alcohol consumption during pregnancy
    Ida N Damgaard
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Environ Health Perspect 115:272-7. 2007
    ..Prenatal exposure to alcohol can adversely affect the fetus. We investigated the association between maternal alcohol consumption during pregnancy and cryptorchidism (undescended testis) among newborn boys...
  63. ncbi Environment and women's reproductive health
    D Caserta
    Institute of Gynecology, Perinatology and Child Health, Sant Andrea Hospital, University of Rome Sapienza, Via di Grottarossa 1035, 00189 Rome, Italy
    Hum Reprod Update 17:418-33. 2011
    ..There is also evidence that ED exposure has trans-generational effects. In this systematic review, we evaluate the evidence for an association between EDC exposure and women's reproductive health...
  64. pmc Ambient carbon monoxide and fine particulate matter in relation to preeclampsia and preterm delivery in western Washington State
    Carole B Rudra
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, State University of New York, Buffalo, New York 14214 8001, USA
    Environ Health Perspect 119:886-92. 2011
    ..Preterm delivery and preeclampsia are common adverse pregnancy outcomes that have been inconsistently associated with ambient air pollutant exposures...
  65. pmc Effects of maternal exposure to cadmium on pregnancy outcome and breast milk
    M Nishijo
    Department of Public Health, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Occup Environ Med 59:394-6; discussion 397. 2002
    ..The relation between maternal exposure to Cd and pregnancy outcome or Cd in breast milk in Japanese mothers was investigated.
  66. pmc Maternal exposure to bisphenol A and genistein has minimal effect on A(vy)/a offspring coat color but favors birth of agouti over nonagouti mice
    Cheryl S Rosenfeld
    Bond Life Sciences Center, Animal Sciences, College of Agriculture, Food and Natural Resources, and Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 110:537-42. 2013
    ..Data suggest that A(vy)/a conceptuses, which may possess a so-called "thrifty genotype," are at a competitive advantage over a/a conceptuses in certain uterine environments...
  67. ncbi Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver
    Peter J O'Shaughnessy
    Institute of Biodiversity, Animal Health, and Comparative Medicine, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom
    J Clin Endocrinol Metab 96:2851-60. 2011
    ..Pollutants and toxicants passing from the mother to the fetus may damage developing organ systems. The human fetal liver is both a potential target organ and a critical defense against exposure to such xenochemicals...
  68. ncbi Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland
    Benjamin J Apelberg
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Sci Technol 41:3891-7. 2007
    ..Our findings suggest that in utero exposure to PFOS and PFOA is ubiquitous in a population of babies born in Baltimore, MD...
  69. ncbi Exposure during pregnancy to glycol ethers and chlorinated solvents and the risk of congenital malformations
    Sylvaine Cordier
    IRSET Inserm U1085 Univ Rennes I IFR 140, Rennes, France sylvaine
    Epidemiology 23:806-12. 2012
    ..Exposure to solvents during pregnancy has long been suspected of increasing the risk of congenital malformations, but the lack of prospective assessment of specific solvent exposures has prevented definitive conclusions...
  70. pmc The National Birth Defects Prevention Study
    P W Yoon
    National Center for Environmental Health, Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA
    Public Health Rep 116:32-40. 2001
    ..The compiled interview data and banked DNA of approximately 35 categories of birth defects will facilitate future research as new hypotheses and improved technologies emerge...
  71. ncbi Effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on fetal brain growth and motor and behavioral development in offspring rats
    Muneko Nishijo
    Department of Public Health, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Toxicol Lett 173:41-7. 2007
    The effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during pregnancy on fetal brain growth and neurobehavioral development in early developmental stages were investigated using rat offspring...
  72. pmc Maternal exposure to ambient levels of benzene and neural tube defects among offspring: Texas, 1999-2004
    Philip J Lupo
    Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston 77030, USA
    Environ Health Perspect 119:397-402. 2011
    Previous studies have reported positive associations between maternal exposure to air pollutants and several adverse birth outcomes...
  73. ncbi Gestational atrazine exposure: effects on male reproductive development and metabolite distribution in the dam, fetus, and neonate
    Melanie J P Fraites
    Endocrine Toxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 32:52-63. 2011
    ..We conclude that, although levels of chlorotriazines within the fetus were considerable, gestational exposures of 1-20mg/kg-d do not lead to alterations in the measures of male development examined in this study...
  74. ncbi Bisphenol A: developmental toxicity from early prenatal exposure
    Mari S Golub
    Office of Environmental Health Hazard Assessment, Reproductive and Cancer Hazard Assessment Branch, Sacramento, California, USA
    Birth Defects Res B Dev Reprod Toxicol 89:441-66. 2010
    ..BPA research has actively integrated current knowledge of developmental biology, concepts of endocrine disruption, and toxicological research to provide a basis for human health risk assessment...
  75. ncbi Prenatal mercury exposure in a multicenter cohort study in Spain
    R Ramon
    Dirección General de Salud Publica, Conselleria de Sanitat, Valencia, Avda Catalunya 21, 46020 Valencia, Spain
    Environ Int 37:597-604. 2011
    ..Mercury is a ubiquitous heavy metal that may negatively affect human health. It is desirable to investigate mercury exposure in vulnerable populations...
  76. pmc Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women
    Kim G Harley
    Center for Environmental Research and Children s Health, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e23923. 2011
    ..We explored whether paraoxonase (PON1), a key enzyme involved in detoxification of OPs, could be an effect modifier in this association...
  77. pmc Low maternal exposure to ultraviolet radiation in pregnancy, month of birth, and risk of multiple sclerosis in offspring: longitudinal analysis
    Judith Staples
    National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australia
    BMJ 340:c1640. 2010
    ..To use the large regional and seasonal variation in ambient ultraviolet radiation in Australia to explore the association between exposure to ultraviolet radiation during pregnancy and subsequent risk of multiple sclerosis in offspring...
  78. pmc Prenatal exposure to environmental tobacco smoke alters gene expression in the developing murine hippocampus
    Partha Mukhopadhyay
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Louisville, Kentucky 40292, USA
    Reprod Toxicol 29:164-75. 2010
    ..Little is known about the effects of passive smoke exposures on the developing brain...
  79. ncbi Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells
    Bianca Schaub
    Department of Pulmonary and Allergy, University Children s Hospital Munich, LMU Munich, Munich, Germany
    J Allergy Clin Immunol 123:774-82.e5. 2009
    Cross-sectional studies suggest that maternal exposure to farming decreases the risk of allergic diseases in offspring. The potential underlying immunologic mechanisms are not understood.
  80. pmc Association of maternal serum concentrations of 2,2', 4,4'5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) levels with birth weight, gestational age and preterm births in Inuit and European populations
    Bogdan J Wojtyniak
    Department Centre of Monitoring and Analyses of Population Health, National Institute of Public Health National Institute of Hygiene, Warsaw, Poland
    Environ Health 9:56. 2010
    Epidemiological studies on the association between maternal exposure to persistent organic pollutants (POPs) and fetal growth alteration report inconsistent findings which weights in favor of additional studies.
  81. ncbi Time-to-event analysis of fine particle air pollution and preterm birth: results from North Carolina, 2001-2005
    Howard H Chang
    Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 175:91-8. 2012
    ..5) exposure and preterm birth. These findings suggest that exposure to ambient PM(2.5) during pregnancy is associated with increased risk of preterm birth, even in a region characterized by relatively good air quality...
  82. ncbi Maternal sleep deprivation is a risk factor for small for gestational age: a cohort study
    Chrishantha Abeysena
    Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka
    Aust N Z J Obstet Gynaecol 49:382-7. 2009
    ..To determine trimester-specific risk factors for small-for-gestational-age (SGA) infants...
  83. ncbi Environmental exposure to dioxins and polychlorinated biphenyls reduce levels of gonadal hormones in newborns: results from the Duisburg cohort study
    Yuguang Cao
    Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    Int J Hyg Environ Health 211:30-9. 2008
    ..This study was done to evaluate effects related to the HPG axis...
  84. ncbi Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development
    Irva Hertz-Picciotto
    Center for Children s Environmental Health and Department of Public Health Sciences, University of California, Davis, CA 95616, USA
    Basic Clin Pharmacol Toxicol 102:146-54. 2008
    ....
  85. ncbi The quality of the early motor repertoire in preterm infants predicts minor neurologic dysfunction at school age
    Janneke L M Bruggink
    Department of Pediatrics, Division of Neonatology, Beatrix Children s Hospital, University Medical Center Groningen, Groningen, The Netherlands
    J Pediatr 153:32-9. 2008
    ..Its predictive power for minor neurologic dysfunction (MND) is unclear. This study aimed to investigate the predictive value of the quality of the early motor repertoire for the development of MND at school age...
  86. pmc Residential exposure to outdoor air pollution during pregnancy and anthropometric measures at birth in a multicenter cohort in Spain
    Marisa Estarlich
    Consortium for Research on Epidemiology and Public Health CIBERESP, Spain
    Environ Health Perspect 119:1333-8. 2011
    ..We assessed the association between exposure to air pollution during pregnancy and anthropometric measures at birth in four areas within the Spanish Children's Health and Environment (INMA) mother and child cohort study...
  87. ncbi Maternal exposure to dexamethasone or cortisol in early pregnancy differentially alters insulin secretion and glucose homeostasis in adult male sheep offspring
    M J De Blasio
    Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide SA 5005, Australia
    Am J Physiol Endocrinol Metab 293:E75-82. 2007
    ..These consequences of glucocorticoid exposure in early pregnancy may lead to pancreatic exhaustion and diabetes longer term and are consistent with stress during early pregnancy contributing to such outcomes in humans...
  88. ncbi Maternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho disease
    Kiyomi Tsukimori
    Department of Obstetrics, Fukuoka Children s Hospital, Japan
    Environ Int 38:79-86. 2012
    Studies on the association of maternal exposure to polychlorinated dibenzo-p-dioxin (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) with decreased birth weight in humans have produced conflicting ..
  89. pmc Comparing exposure assessment methods for traffic-related air pollution in an adverse pregnancy outcome study
    Jun Wu
    Program in Public Health and Department of Epidemiology, Anteater Instruction and Research Office, University of California, Irvine, CA 92697 3957, USA
    Environ Res 111:685-92. 2011
    ..Yet, little information exists on how effect estimates are impacted by the different exposure assessment methods employed in these studies...
  90. ncbi Prenatal pesticide and PCB exposures and birth outcomes
    Mary S Wolff
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Pediatr Res 61:243-50. 2007
    ..We measured biomarkers of maternal exposure to DDE, PCB, and OP metabolites in the third trimester of pregnancy among 404 mothers in a multiethnic ..
  91. pmc A quasi-experimental study of maternal smoking during pregnancy and offspring academic achievement
    Brian M D'Onofrio
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Child Dev 81:80-100. 2010
    ..The pattern of results suggests that genetic factors shared by parents and their offspring help explain why offspring exposed to SDP have lower levels of AA...
  92. pmc Environmental exposures and development
    Donald R Mattison
    Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
    Curr Opin Pediatr 22:208-18. 2010
    ....
  93. pmc Postnatal exposure to methyl mercury from fish consumption: a review and new data from the Seychelles Child Development Study
    Gary J Myers
    University of Rochester School of Medicine and Dentistry, Department of Neurology, Rochester, NY, United States
    Neurotoxicology 30:338-49. 2009
    ....
  94. ncbi Neonatal S100B protein levels after prenatal exposure to selective serotonin reuptake inhibitors
    Jodi L Pawluski
    Department of Pediatrics, University of British Columbia, Vancouver, Canada
    Pediatrics 124:e662-70. 2009
    ..This study investigated neonatal S100B levels as a biomarker of prenatal selective serotonin reuptake inhibitor (SSRI) exposure...
  95. ncbi Maternal exposure to floricultural work during pregnancy, PON1 Q192R polymorphisms and the risk of low birth weight
    G Moreno-Banda
    Population Health Research Center, National Institute of Public Health, Avenida Universidad 655, Colonia Santa Maria Ahuacatitlan, 62508 Cuernavaca, Morelos, Mexico
    Sci Total Environ 407:5478-85. 2009
    ..Paraoxonase (PON1) detoxifies organophosphates by cleavage of active oxons. Some PON1 gene polymorphisms could reduce the enzyme activity and increase susceptibility to OP toxicity...
  96. ncbi Serum hormones in boys prenatally exposed to polychlorinated biphenyls and dibenzofurans
    Ping Chi Hsu
    Department of Safety, Health and Environmental Engineering, National Kaohsiung First University of Science and Technology, Kaohsiung, Taiwan
    J Toxicol Environ Health A 68:1447-56. 2005
    ..Further studies are needed to identify the congeners of PCBs/PCDFs responsible for disruption of the endocrine system, as well as the mechanisms of such disruption...
  97. pmc No association between ambient particulate matter exposure during pregnancy and stillbirth risk in the north of England, 1962-1992
    M S Pearce
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Environ Res 110:118-22. 2010
    ..This potential association was examined using data from the historical cohort UK Particulate Matter and Perinatal Events Research (PAMPER) study...
  98. ncbi Maternal tobacco exposure and cotinine levels in fetal fluids in the first half of pregnancy
    E Jauniaux
    Academic Department of Obstetrics and Gynaecology, University College London, United Kingdom
    Obstet Gynecol 93:25-9. 1999
    ..To evaluate the distribution of cotinine in fetal fluids and serum during the first half of pregnancy, and compare the fetal and maternal cotinine levels in passive and active smokers...
  99. pmc Maternal smoking and birth defects: validity of birth certificate data for effect estimation
    M A Honein
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Mailstop F-45, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Public Health Rep 116:327-35. 2001
    ..CONCLUSIONS: These findings suggest that birth certificate data may be useful for exploratory or corroborative studies estimating the association between birth defects and some risk factors recorded on birth certificates...
  100. ncbi Nicotine exposure affects mother's and pup's nutritional, biochemical, and hormonal profiles during lactation in rats
    E Oliveira
    Department of Physiological Sciences, Roberto Alcantara Gomes Biology Institute Laboratory of Lipids, School of Medicine, State University of Rio de Janeiro, Rio de Janeiro 20551 030, Brazil
    J Endocrinol 205:159-70. 2010
    ..The pattern of these effects is clearly distinct when comparing the nicotine-exposed group to the withdrawal group, which could be important for the programming effects observed previously...
  101. pmc Arsenic, stem cells, and the developmental basis of adult cancer
    Erik J Tokar
    National Toxicology Program Laboratories, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Toxicol Sci 120:S192-203. 2011
    ..A mouse transplacental model has been developed where maternal exposure to inorganic arsenic either acts as a complete carcinogen or enhances carcinogenic response to other agents ..

Research Grants63

  1. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 2013
    ..5, a key determinant of cardiac morphogenesis. Our rationale is that mutations in the NKX2.5 gene and maternal exposure to halogenated hydrocarbons, dioxins and polychlorinated biphenyls during pregnancy are the main known risk ..
  2. Transgenerational effects of maternal high fat diet during pregnancy on breast ca
    Leena A Hilakivi-Clarke; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Maternal exposure to a high fat (HF) diet during pregnancy increases estrogen receptor (ER+) and ER- mammary cancer risk among female offspring in animal models and in humans...
  3. Air Toxics, Neighborhood Environment and Risk of Oral Clefts
    Philip J Lupo; Fiscal Year: 2013
    ..g., ozone). Although there is evidence from occupational studies that maternal exposure to certain HAPs is associated with CL[unreadable]P, the teratogenic potential of environmental ..
  4. Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth
    MICHELLE WILHELM TURNER; Fiscal Year: 2010
    ..We hypothesize that maternal exposure to traffic-related air pollutants during pregnancy results in reductions in fetal growth, and that part of ..
  5. Phthalate Exposure and Pregnancy Outcome
    T Peter Stein; Fiscal Year: 2010
    ..The objective of this project is to test the hypothesis that maternal exposure to phthalates early in pregnancy has an adverse effect on pregnancy outcome...
  6. Transgenerational Inheritance of Epigenetic Effects of Polychlorinated Biphenyls
    Charles V Vorhees; Fiscal Year: 2013
    ..Similarly, maternal exposure during pregnancy to PCBs and other halogenated hydrocarbons has been associated with a higher incidence of ..
  7. Phthalates in Drugs and Male Genital Malformation
    Allen A Mitchell; Fiscal Year: 2012
    ..We therefore propose to evaluate the risks of male genital malformations after maternal exposure to specific types of phthalates contained in medications as "inactive" ingredients...
  8. FUNCTION AND BIOLOGY OF EUKARYOTIC DNA TOPOISOMERASES
    Neil Osheroff; Fiscal Year: 2013
    ..also are seen in infant AMLs, and the risk of these leukemias rises ~3-fold when there is high maternal exposure during pregnancy to environmental and dietary topoisomerase II poisons...
  9. Mechanisms of Valproic Acid-Induced Neurodevelopmental and Behavioral Defects
    Elizabeth M Powell; Fiscal Year: 2013
    ..The severity of effects appears to be dependent upon gestational time of maternal exposure. VPA is a histone deacetylase inhibitor, suggesting that it interferes with gene expression by an epigenetic ..
  10. Air pollution and fetal growth in China
    Yawei Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): While increasing evidence suggests that maternal exposure to high levels of ambient air pollutants during pregnancy plays a critical role in producing adverse pregnancy outcomes, most of the early ..
  11. The Iowa Flood Study: Perinatal Effects of a Natural Disaster
    MICHAEL WILLIAM O apos HARA; Fiscal Year: 2010
    ..the goal of this project is to increase our understanding of the mechanisms responsible for the effects of maternal exposure to varying levels of hardship, and the pregnant women's subjective reactions to these hardships, ..
  12. IL-1?? as a mediator of maternal infection-induced effects on offspring neuroinfl
    Heping Zhou; Fiscal Year: 2010
    ..Our laboratory has found that maternal exposure to lipopolysaccharide (LPS), a major component of Gram-negative bacteria cell wall, attenuated the mRNA ..
  13. Parental exposure to ionizing radiation and birth defects
    DOROTHY KIM WALLER; Fiscal Year: 2013
    ..Further, maternal exposure to ionizing radiation in early pregnancy may result in the death of rapidly dividing cells in the developing ..
  14. PATERNAL OPIOID EXPOSURE IMPARTS BIOBEHAVIORAL DEFICITS IN THEIR OFFSPRING
    Theodore J Cicero; Fiscal Year: 2013
    ..Research on the effects of maternal exposure to exogenous agents on offspring viability and function has resulted in laws and educational programs to ..
  15. Effect of Air Pollution and Traffic on Birth Outcomes
    Michelle L Bell; Fiscal Year: 2012
    ..We propose to investigate the hypothesis that maternal exposure during pregnancy to ambient air pollution (CO, NO2, O3,, PM2...
  16. New Model Leading to Preterm Delivery: Role of Exposure to Environmental Toxins
    Nazeeh N Hanna; Fiscal Year: 2010
    ..Epidemiologic studies have suggested a strong association between maternal exposure to TCDD and preterm birth...
  17. Naphthalene exposure, chromosomal aberrations in poor urban school children.
    Manuela A Orjuela; Fiscal Year: 2012
    ..Environmental Health (CCCEH) birth cohort of Latino and African-American children in NYC, prenatal maternal exposure to airborne PAH is associated with infant chromosomal aberrations (CAs) measured in cord blood using Whole ..
  18. Prenatal Exposure to Solid Fuel Smoke and Birth Outcomes in Sri Lanka
    Nalini Sathiakumar; Fiscal Year: 2011
    ..by applicant): Solid fuel combustion in inefficient cooking stoves in poorly ventilated areas causes heavy maternal exposure to carbon monoxide (CO) and to fine particulate matter (PM2.5), both known to cause fetal anoxia...
  19. Inflammatory Cytokine Polymorphisms, Air Pollution, and Very Preterm Birth
    Ondine von Ehrenstein; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We proposes to examine the hypotheses that maternal exposure to air pollutants during pregnancy is associated with an increased risk of very preterm birth (VPTB, <32 weeks gestation), and that ..
  20. Environmenal epigenitics and innate immunity
    John W Hollingsworth; Fiscal Year: 2012
    ..Our previous work showing that maternal exposure to a diet rich in methyl donors alters heritable risk of allergic airways disease through enhanced CpG ..
  21. Arsenic Contaminated Water Consumption &Spontaneous Pregnancy Loss in Romania
    Michael S Bloom; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Maternal exposure to concentrations of inorganic arsenic (iAs) in excess of 10 parts per billion (ppb) has been identified as a risk factor for clinically recognized spontaneous pregnancy loss in ..
  22. PEDIGREE: Prenatal Environmental Determinants of InterGenerational Risk
    Mary Beth Terry; Fiscal Year: 2013
    ..adult daughter specimens for DNA methylation, supports new data analysis to 1) test a novel hypothesis that maternal exposure during a critical window (prior to age 14) increases susceptibility of the fetus to the effects of ..
  23. Residential Air Pollution and Preeclampsia
    Gregory A Wellenius; Fiscal Year: 2013
    ..b>Maternal exposure to air pollution may also be associated with slower fetal growth, lower birth weight, and higher risk of ..
  24. Associations between Ambient Air Pollution and Adverse Birth Outcomes in Florida
    Xiaohui Xu; Fiscal Year: 2013
    ..Growing epidemiological evidence suggests associations between maternal exposure to ambient air pollution and adverse pregnancy outcomes. However, the findings have been inconsistent...
  25. Effects of a Major Climatic Event -Superstorm Sandy- on Pregnancy Outcomes and Te
    CATHERINE E MONK; Fiscal Year: 2013
    ..Further, maternal exposure to stressful events may be associated with decreases in leukocyte telomere length (LTL) in the newborn...
  26. Mechanisms of Drug Disposition During Pregnancy
    Jashvant D Unadkat; Fiscal Year: 2013
    ..Pregnancy is known to induce expression and activity of hepatic CYP3A and CYP2D6, thus possibly lowering maternal exposure to drugs and potentially decreasing their efficacy...
  27. Tracking Air Pollutants and Newborn Health in Houston, Texas
    Elaine Symanski; Fiscal Year: 2011
    ..The specific aims of the investigation are to: 1) estimate maternal exposure to PM2...
  28. Gene-Specific Epigenetic Programming of WNT Signaling Pathway by Dietary Soy
    Hong Chen; Fiscal Year: 2009
    ..An early maternal exposure model will be used for epigenetic programming by soy foods in colon of offspring rats...
  29. Current-Use Flame Retardants: Maternal Exposure and Neurodevelopment in Children
    Asa Bradman; Fiscal Year: 2013
    ..This new information about human exposure to OPFRs will support the development of more comprehensive studies by applying innovative scientific methods to address key knowledge gaps about OPFR exposure and health effects. ..
  30. Study of Neural Tube Defects Etiology: Genome and Exposome
    Huiping Zhu; Fiscal Year: 2013
    ..The results of our studies will help defining the relationships among maternal exposure, maternal nutrition, immune responses, maternal/embryonic genetics, and NTD risk...
  31. Interpersonal Psychotherapy for Depressed Mothers of Psychiatrically Ill Children
    Holly A Swartz; Fiscal Year: 2013
    ..Exploratory aims are to evaluate potential moderators and mediators of child outcomes such as early maternal exposure to trauma, family socioeconomic status, current level of domestic conflict, maternal parenting style, and ..
  32. Prenatal Bisphenol A and Lung Maturation
    Laura S Van Winkle; Fiscal Year: 2013
    ..There is some evidence for a link between BPA exposures and asthma, maternal exposure to BPA in mice increases hallmarks of asthma in offspring...
  33. Arsenic and the Risk of Neural Tube Defects in China
    Analee J Etheredge; Fiscal Year: 2010
    ..This prospective epidemiological study will examine the hypotheses that NTD risk is associated with maternal exposure to inorganic arsenic (Asi) and that this association may be modified by nutritional or genetic factors...
  34. Methods to Detect Maternal Exposures and Child Outcomes
    SUZANNE W MCDERMOTT; Fiscal Year: 2012
    ..the relationship between the child outcomes of developmental disability and mental retardation (DD/MR) and maternal exposure to chemicals in soil during each month of pregnancy...
  35. Parenting Intervention Development and Assessment with Substance Abusing Mothers
    Nancy E Suchman; Fiscal Year: 2012
    ..mothers who are caring for infants and toddlers and (b) tests hypothesized cyclical mechanisms linking maternal exposure to typical parenting stressors, maternal affect dysregulation and risk for relapse to drug use, maternal ..
  36. EFFECTS OF COCAINE ON PLACENTAL GROWTH FACTORS
    Kathleen Shiverick; Fiscal Year: 1993
    ..autophosphorylation will be characterized in basal zone and decidua portions of placental tissue following maternal exposure to doses of cocaine which produce placental growth retardation...
  37. EPIDEMIOLOGY OF INFANT LEUKEMIA
    Julie Ross; Fiscal Year: 2007
    ..Our preliminary data indicate that maternal exposure to environmental agents, including DNA topoisomerase II inhibitors, are important in the etiology of infant ..
  38. VITAMIN K-DEPENDENT PROTEINS IN BLOOD AND DEVELOPMENT
    David Roth; Fiscal Year: 2001
    ..Warfarin is also a teratogen. Human maternal exposure to warfarin during pregnancy is associated with developmental abnormalities in the fetus, the warfarin ..
  39. HAIR ANALYSIS TO MONITOR DRUG ABUSE TREATMENTS
    Diana Wilkins; Fiscal Year: 2001
    ..Specifically, we will determine if there is a relationship between maternal exposure to a treatment drug (methadone) during pregnancy and neonatal hair concentrations of methadone at birth...
  40. Feto-Maternal Pharmacokinetics of Abused Inhalants
    STEPHEN DEWEY; Fiscal Year: 2004
    ..However, data are lacking to relate the degree of maternal exposure to toluene and other inhalant drugs of abuse to their effects on the fetus...
  41. Methods development and secondary analyses for an oral clefts association study
    Ingo Ruczinski; Fiscal Year: 2012
    ..We therefore propose the development of novel statistical techniques, and to carry additional analyses on maternal exposure and the available genome scan data from more than 2000 complete case-parent trios, to further investigate ..
  42. ORGANOCHLORINE PESTICIDES AND SEROTONERGIC DEVELOPMENT
    Jean Lauder; Fiscal Year: 2000
    The General Aim of this project is to determine possible consequences of maternal exposure to organochlorine pesticides, such as dieldrin, on development of serotonin (5-HT) neurons and their receptors in offspring...
  43. Prenatal pesticide exposure in South Africa: CNS Effects
    Roberta White; Fiscal Year: 2005
    ..are particularly susceptible to the effects of environmental exposure to pesticides in utero because of maternal exposure to pesticides...
  44. XENOBIOTIC METABOLISM IN FETAL HEMATOPOIETIC CELLS
    Kathleen Shiverick; Fiscal Year: 1992
    The proposed research will assess the fetal hematopoietic toxicity of maternal exposure to the polyaromatic compounds beta- naphthoflavone (beta NF), 3-methylcholanthrene (MC), and 2, 3, 7, 8-tetrachloro-dibenzo-p-dioxin (TCDD)...
  45. Early Identification of Affected Children and Risk Factors for FASD in Ukraine
    Christina Chambers; Fiscal Year: 2013
    ..intervention trial, to examine the role of postnatal child nutrition in FASD, an to explore genetic and epigenetic factors as biomarkers of maternal exposure and risk modification among alcohol consuming pregnant women.
  46. Role of CYP2E1 and ADH in Human TRI Teratogenicity
    D McCarver; Fiscal Year: 2005
    ..aims are to 1) prospectively determine the risk of congenital heart disease from commonly observed levels of maternal exposure to trichlorinated hydrocarbons during pregnancy and 2) determine the differences in the offspring risk for ..
  47. Maternal Phthalate Exposure and Infertility, Fetal Loss
    Russ Hauser; Fiscal Year: 2007
    ..The proposed study will focus on maternal exposure to phthalates. IVF will be used as a model system to assess the early stages of development...
  48. Effects of Maternal Diet on SNS Development in Offspring
    James Young; Fiscal Year: 2009
    ..b>Maternal exposure to diets enriched in refined carbohydrates (sucrose and starch) increases SNS innervation in these two ..
  49. Exploring epigenetic mechanisms of developmental immunology
    B Paige Lawrence; Fiscal Year: 2007
    ..observations suggest that the effects of TCDD on immune function are long-lasting and may be imprinted by maternal exposure. The proposed studies utilize resources and expertise provided by the Genomics and Bio-Informatics Core ..
  50. RISK FACTORS FOR PULMONARY HYPERTENSION OF THE NEWBORN
    ALLEN MITCHELL; Fiscal Year: 2002
    ..The investigators propose to conduct a multicenter case-control study of PPHN in relation to maternal exposure to smoking and NSAIDs...
  51. In-utero Exposure and Infant Loss of IGF2 Imprinting
    Cathrine Hoyo; Fiscal Year: 2007
    ..methylation patterns and estimate the prevalence of LOI in IGF2 in-utero; 2) To evaluate whether maternal exposure to cigarette smoking is associated with LOI in IGF2; and 3) To evaluate whether LOI in IGF2 is associated ..
  52. ENVIRONMENTAL TEMPERATURE, SNS DEVELOPMENT AND OBESITY
    James Young; Fiscal Year: 2005
    ..Furthermore, since these exposures are not mutually exclusive of one another, the applicants propose that maternal exposure both to glucocorticoids and to a synthetic diet will interact synergistically to exaggerate tendencies in ..
  53. Placenta: Ethanol and HIV
    Richard Miller; Fiscal Year: 2004
    ..It has been suggested that the placenta's protective role may be compromised by maternal exposure to ethanol. While no data are available to suggest how this might occur, there are two obvious hypotheses...
  54. PRENATAL NICOTINE EXPOSURE, THE CIRCADIAN SYSTEM & SIDS
    THOMAS KILDUFF; Fiscal Year: 2000
    ..are exposed to significant levels of nicotine both through active smoking by their mothers and through maternal exposure to passive smoke...
  55. LIFESTYLE FACTORS AFFECTING FETAL SOMATIC MUTATION
    William Bigbee; Fiscal Year: 1999
    ..follows the investigators' initial survey of somatic mutation in newborns in which they found that maternal exposure to tobacco smoke and lower socioeconomic status, perhaps because of its association with maternal lifestyle ..
  56. PARENT AND CHILD EXPOSURE TO COMMUNITY VIOLENCE
    Eugene Aisenberg; Fiscal Year: 2000
    ..namely, PTSD, depression and anxiety, based on reports from students and mothers; 3) describe and identify maternal exposure to community violence and other forms of violence such as sexual abuse based on self-reports; 4) assess ..
  57. Fetal pancreatic development & insulin secretion
    William Hay; Fiscal Year: 2006
    ..The proposed studies will be conducted in our ovine model of IUGR produced by maternal exposure to a moderately hyperthermic environment during gestation...
  58. ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONS
    Janee Gelineau van Waes; Fiscal Year: 2003
    Congenital malformations of the heart have been reported following maternal exposure to various environmental toxins, but the precise mechanism(s) by which these teratogenic exposures disrupt normal morphogenesis remains unknown...
  59. Secondhand Smoke and Cardiovascular Disease in Zebrafish
    KAREN SETA AUST; Fiscal Year: 2007
    ..One well-studied effect of maternal exposure to ETS during pregnancy is intrauterine growth retardation...
  60. Imaging in Developmental Toxicology
    Debashish Roy; Fiscal Year: 2009
    ..Following maternal exposure to TCDD, which is known to affect vascular development, we will analyze fetuses both by conventional manual ..
  61. Prenatal factors and risk of autism in a Finnish national birth cohort
    ALAN STEWART BROWN; Fiscal Year: 2010
    ....
  62. DEVELOPMENTAL INSULT AND BRAIN ANOMALY IN SCHIZOPHRENIA
    Alan Brown; Fiscal Year: 2004
    ....
  63. Prenatal Factors and Risk of Bipolar Disorder
    ALAN STEWART BROWN; Fiscal Year: 2010
    ....