inhalation exposure

Summary

Summary: The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.

Top Publications

  1. ncbi Translocation of inhaled ultrafine particles to the brain
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Inhal Toxicol 16:437-45. 2004
  2. ncbi Nanoparticles: a review of particle toxicology following inhalation exposure
    Shahnaz Bakand
    School of Chemistry, The University of New South Wales, Sydney, Australia
    Inhal Toxicol 24:125-35. 2012
  3. ncbi Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Avenue, Medical Center, Rochester, NY 14642, USA
    J Intern Med 267:89-105. 2010
  4. ncbi Adverse cardiovascular effects of air pollution
    Nicholas L Mills
    Centre for Cardiovascular Science, University of Edinburgh, UK
    Nat Clin Pract Cardiovasc Med 6:36-44. 2009
  5. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
  6. ncbi Changes in atherosclerotic plaques induced by inhalation of diesel exhaust
    Ni Bai
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    Atherosclerosis 216:299-306. 2011
  7. pmc Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans
    Robert D Brook
    University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Hypertension 54:659-67. 2009
  8. ncbi Woodsmoke health effects: a review
    Luke P Naeher
    Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia, USA
    Inhal Toxicol 19:67-106. 2007
  9. pmc Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing
    Wan Seob Cho
    ELEGI The Edinburgh Lung and the Environment Group Initiative, Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 118:1699-706. 2010
  10. ncbi Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs
    Wolfgang G Kreyling
    Helmholtz Center Munich, Neuherberg Munich, Germany
    Inhal Toxicol 21:55-60. 2009

Detail Information

Publications315 found, 100 shown here

  1. ncbi Translocation of inhaled ultrafine particles to the brain
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Inhal Toxicol 16:437-45. 2004
    ..It could provide a portal of entry into the CNS for solid UFP, circumventing the tight blood-brain barrier. Whether this translocation of inhaled UFP can cause CNS effects needs to be determined in future studies...
  2. ncbi Nanoparticles: a review of particle toxicology following inhalation exposure
    Shahnaz Bakand
    School of Chemistry, The University of New South Wales, Sydney, Australia
    Inhal Toxicol 24:125-35. 2012
    ..Current advances and limitations of toxicity assessment methods of nanoparticles are discussed highlighting the recent improvements of in vitro screening tools for the safety evaluation of the rapidly expanding area of nanotechnology...
  3. ncbi Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology
    G Oberdorster
    Department of Environmental Medicine, University of Rochester, 601 Elmwood Avenue, Medical Center, Rochester, NY 14642, USA
    J Intern Med 267:89-105. 2010
    ....
  4. ncbi Adverse cardiovascular effects of air pollution
    Nicholas L Mills
    Centre for Cardiovascular Science, University of Edinburgh, UK
    Nat Clin Pract Cardiovasc Med 6:36-44. 2009
    ..An increased understanding of the mediators and mechanisms of these processes is necessary if we are to develop strategies to protect individuals at risk and reduce the effect of air pollution on cardiovascular disease...
  5. ncbi Toxic potential of materials at the nanolevel
    Andre Nel
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:622-7. 2006
    ..The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable...
  6. ncbi Changes in atherosclerotic plaques induced by inhalation of diesel exhaust
    Ni Bai
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    Atherosclerosis 216:299-306. 2011
    ..We hypothesize that exposure to diesel exhaust (DE), an important source of traffic-related particulate air pollution, promotes changes of atherosclerotic plaque component that may lead to plaque vulnerability...
  7. pmc Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans
    Robert D Brook
    University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Hypertension 54:659-67. 2009
    ..Our findings demonstrate credible mechanisms whereby fine particulate matter could trigger acute cardiovascular events and that aspects of exposure location may be an important determinant of the health consequences...
  8. ncbi Woodsmoke health effects: a review
    Luke P Naeher
    Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia, USA
    Inhal Toxicol 19:67-106. 2007
    ..In addition, we provide recommendations for additional woodsmoke research...
  9. pmc Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing
    Wan Seob Cho
    ELEGI The Edinburgh Lung and the Environment Group Initiative, Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 118:1699-706. 2010
    ..Metal oxide nanoparticles (NPs) have been widely used in industry, cosmetics, and biomedicine...
  10. ncbi Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs
    Wolfgang G Kreyling
    Helmholtz Center Munich, Neuherberg Munich, Germany
    Inhal Toxicol 21:55-60. 2009
    ..These studies show that both NP characteristics--the material and the size of the chain-type aggregates--determine translocation and accumulation in STOs, skeleton, and soft tissue...
  11. pmc Deposition and biokinetics of inhaled nanoparticles
    Marianne Geiser
    Institute of Anatomy, University of Bern, Baltzerstrasse 2, CH 3000 Bern 9, Switzerland
    Part Fibre Toxicol 7:2. 2010
    ..We emphasize the importance for quantitative analyses and the use of particle doses derived from real world exposures...
  12. pmc Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States
    J A Jernigan
    NCID, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 7:933-44. 2001
    ..With multidrug antibiotic regimens and supportive care, survival of patients (60%) was markedly higher (<15%) than previously reported...
  13. ncbi Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures
    Jürgen Pauluhn
    Department of Inhalation Toxicology, Institute of Toxicology, Bayer Schering Pharma, Building Number 514, 42096 Wuppertal, Germany
    Toxicol Sci 113:226-42. 2010
    ..Thus, the hypothesis of study is verified, namely, common denominators between carbon black and MWCNT do exist...
  14. pmc Blood pressure response to controlled diesel exhaust exposure in human subjects
    Kristen E Cosselman
    University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, WA 98105, USA
    Hypertension 59:943-8. 2012
    ..This controlled trial in humans confirms findings from observational studies. The effect may be important on a population basis given the worldwide prevalence of exposure to traffic-related air pollution...
  15. ncbi Diesel exhaust induces systemic lipid peroxidation and development of dysfunctional pro-oxidant and pro-inflammatory high-density lipoprotein
    Fen Yin
    Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 33:1153-61. 2013
    ..To evaluate whether exposure to air pollutants induces oxidative modifications of plasma lipoproteins, resulting in alteration of the protective capacities of high-density lipoproteins (HDLs)...
  16. ncbi An air filter intervention study of endothelial function among healthy adults in a woodsmoke-impacted community
    Ryan W Allen
    Simon Fraser University, Faculty of Health Sciences, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada
    Am J Respir Crit Care Med 183:1222-30. 2011
    ..Particulate air pollution is associated with cardiovascular morbidity. One hypothesized mechanism involves oxidative stress, systemic inflammation, and endothelial dysfunction...
  17. pmc Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions
    Stefan Barath
    Department of Public Health and Clinical Medicine, Umea University, Sweden
    Part Fibre Toxicol 7:19. 2010
    ..Controlled human exposure studies have demonstrated impaired vascular function after inhalation of exhaust generated by a diesel engine under idling conditions...
  18. ncbi Occupational exposure assessment in carbon nanotube and nanofiber primary and secondary manufacturers
    Matthew M Dahm
    Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, 4676 Columbia Parkway, MS R14, Cincinnati, OH 45226, USA
    Ann Occup Hyg 56:542-56. 2012
    ..To address this gap, exposure assessments were conducted at six representative sites identified as CNT/CNF primary or secondary manufacturers...
  19. ncbi A controlled inhalation diesel exhaust exposure facility with dynamic feedback control of PM concentration
    Timothy Gould
    Department of Civil and Environmental Engineering, University of Washington, Seattle, Washington 98195 2700, USA
    Inhal Toxicol 20:49-52. 2008
    A facility has been assembled that provides a controlled inhalation exposure to freshly diluted and mixed diesel exhaust using a diesel engine under load and a two-stage exhaust dilution system with dynamic feedback control...
  20. ncbi Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles
    Christie M Sayes
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Sci 97:163-80. 2007
    ..It seems clear that in vitro cellular systems will need to be further developed, standardized, and validated (relative to in vivo effects) in order to provide useful screening data on the relative toxicity of inhaled particle types...
  21. ncbi Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes
    Leah A Mitchell
    College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
    Toxicol Sci 100:203-14. 2007
    ..No changes in gene expression were observed in lung; however, interleukin-10 (IL-10) and NAD(P)H oxidoreductase 1 mRNA levels were increased in spleen...
  22. pmc The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area
    Claire Monteiller
    Institute of Occupational Medicine, Research Park North, Edinburgh, UK
    Occup Environ Med 64:609-15. 2007
    ....
  23. pmc Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm
    Vicki H Grassian
    Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Environ Health Perspect 115:397-402. 2007
    ..Nanotechnology offers great promise in many industrial applications. However, little is known about the health effects of manufactured nanoparticles, the building blocks of nanomaterials...
  24. pmc Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findings
    Daniel B Jernigan
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Emerg Infect Dis 8:1019-28. 2002
    ..Continued vigilance for cases is needed among health-care providers and members of the public health and law enforcement communities...
  25. ncbi Toward understanding the risk of secondary airborne infection: emission of respirable pathogens
    Mark Nicas
    School of Public Health, University of California, Berkeley, Berkeley, California 94720, USA
    J Occup Environ Hyg 2:143-54. 2005
    ....
  26. ncbi Exposure characterization of metal oxide nanoparticles in the workplace
    Brian Curwin
    National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio 45226, USA
    J Occup Environ Hyg 8:580-7. 2011
    ..1 and 1 μm. The greatest potential for exposure to workers occurred during the handling process. However, the exposure is occurring at levels that are well below established and proposed limits...
  27. ncbi Effects on airways of short-term exposure to two kinds of wood smoke in a chamber study of healthy humans
    Leo Stockfelt
    Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy, University of Gothenburg, Gothenburg, Sweden
    Inhal Toxicol 24:47-59. 2012
    ..Wood smoke is a significant contributor to air pollution, with complex and varying composition. We examined airway effects of two kinds of wood smoke in a chamber study...
  28. pmc Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain
    Damien van Berlo
    Institut für umweltmedizinische Forschung an der Heinrich Heine Universität Düsseldorf gGmbH, Dusseldorf, Germany
    Arch Toxicol 84:553-62. 2010
    ..The aim of our study was to comparatively evaluate the effects of short-term diesel engine exhaust (DEE) inhalation exposure on rat brain and lung. After 4 or 18 h recovery from a 2 h nose-only exposure to DEE (1...
  29. pmc Acute effects of air pollution on pulmonary function, airway inflammation, and oxidative stress in asthmatic children
    Ling Liu
    Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, Ontario, Canada
    Environ Health Perspect 117:668-74. 2009
    ..Air pollution is associated with respiratory symptoms, lung function decrements, and hospitalizations. However, there is little information about the influence of air pollution on lung injury...
  30. pmc Effect of early particulate air pollution exposure on obesity in mice: role of p47phox
    Xiaohua Xu
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus 43210, USA
    Arterioscler Thromb Vasc Biol 30:2518-27. 2010
    ..5 μm [PM(2.5)]) pollution on metabolic parameters, inflammation, and adiposity; and to investigate the involvement of oxidative stress pathways in the development of metabolic abnormalities...
  31. pmc Long-term inhalation exposure to nickel nanoparticles exacerbated atherosclerosis in a susceptible mouse model
    Gi Soo Kang
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York, USA
    Environ Health Perspect 119:176-81. 2011
    ....
  32. ncbi Nanoparticle Emission Assessment Technique (NEAT) for the identification and measurement of potential inhalation exposure to engineered nanomaterials--Part B: Results from 12 field studies
    M Methner
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA
    J Occup Environ Hyg 7:163-76. 2010
    ..The results demonstrated that the NEAT was useful in evaluating emissions and that readily available engineering controls can be applied to minimize nanomaterial emissions...
  33. ncbi Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation
    Chiu wing Lam
    Space and Life Sciences, NASA Johnson Space Center, Houston, Texas 77058, USA
    Toxicol Sci 77:126-34. 2004
    ....
  34. ncbi Development of a short-term inhalation test in the rat using nano-titanium dioxide as a model substance
    Lan Ma-Hock
    Department of Product Safety, BASF SE, Ludwigshafen, Germany
    Inhal Toxicol 21:102-18. 2009
    ..Overall, the pulmonary effects of nano-TiO2 observed in this short-term study were comparable to those previously reported in subchronic inhalation studies...
  35. pmc Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase
    Zhekang Ying
    Davis Heart Lung Research Institute, The Ohio State Univ, Rm 110, 473 W 12th Ave, Columbus, OH 43210 1252, USA
    Am J Physiol Heart Circ Physiol 296:H1540-50. 2009
    ..In conclusion, PM(2.5) potentiates cardiac remodeling in response to ANG II through RhoA/Rho kinase-dependent mechanisms. These findings have implications for the chronic cardiovascular health effects of air pollution...
  36. ncbi Systemic inflammation, endothelial dysfunction, and activation in clinically healthy children exposed to air pollutants
    L Calderon-Garciduenas
    Instituto Nacional de Pediatria, Mexico City, Mexico
    Inhal Toxicol 20:499-506. 2008
    ..Children chronically exposed to fine PM above the standard could be at risk of developing cardiovascular diseases, atherosclerosis, stroke, and other systemic effects later in life...
  37. ncbi Fungal spores: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting
    Wijnand Eduard
    National Institute of Occupational Health, Oslo, Norway
    Crit Rev Toxicol 39:799-864. 2009
    ..Mycotoxin-producing and pathogenic species have to be detected specifically, however, because of their higher toxicity...
  38. ncbi Experimental exposure to wood-smoke particles in healthy humans: effects on markers of inflammation, coagulation, and lipid peroxidation
    Lars Barregard
    Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy, Goteborg University, Goteborg, Sweden
    Inhal Toxicol 18:845-53. 2006
    ..These factors may be involved in the mechanisms whereby particulate air pollution affects cardiovascular morbidity and mortality. The exposure setup could be used to establish which particle characteristics are critical for the effects...
  39. pmc Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozone
    Asghar A Fakhri
    Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:1287-92. 2009
    ....
  40. ncbi Airway exposure to silica-coated TiO2 nanoparticles induces pulmonary neutrophilia in mice
    Elina M Rossi
    Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Toxicol Sci 113:422-33. 2010
    ..Our findings emphasize that it is vitally important to take into account in the risk assessment that alterations of nanoparticles, e.g., by surface coating, may drastically change their toxicological potential...
  41. ncbi Lung function changes in Sprague-Dawley rats after prolonged inhalation exposure to silver nanoparticles
    Jae Hyuck Sung
    Korea Environment and Merchandise Testing Institute, Incheon, Korea
    Inhal Toxicol 20:567-74. 2008
    ..to investigate the inflammatory responses and pulmonary function changes in rats during 90 days of inhalation exposure to silver nanoparticles...
  42. ncbi Temporal evolution of nanoparticle aerosols in workplace exposure
    M Seipenbusch
    Institut für Mechanische Verfahrenstechnik und Mechanik, Universitat Karlsruhe, 76128 Karlsruhe, Germany
    Ann Occup Hyg 52:707-16. 2008
    ..It is shown that the NPs are still chemically present in the aerosol after becoming attached to background particles, thus remaining airborne while being invisible in the size distribution...
  43. pmc The effect of inhaled chromium on different exhaled breath condensate biomarkers among chrome-plating workers
    Andrea Caglieri
    Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    Environ Health Perspect 114:542-6. 2006
    ..05). The results of this study demonstrate that EBC is a suitable matrix that can be used to investigate both Cr levels and biomarkers of free radical production sampling the epithelial-lining fluid of workers exposed to Cr(VI)...
  44. pmc Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease
    Shannon Levesque
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298, USA
    J Neuroinflammation 8:105. 2011
    ..Increasing evidence links diverse forms of air pollution to neuroinflammation and neuropathology in both human and animal models, but the effects of long-term exposures are poorly understood...
  45. pmc Rapid DNA methylation changes after exposure to traffic particles
    Andrea Baccarelli
    Laboratory of Environmental Epigenetics, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, 20122 Milan, Italy
    Am J Respir Crit Care Med 179:572-8. 2009
    ..Lower blood DNA methylation content is found in processes related to cardiovascular outcomes, such as oxidative stress, aging, and atherosclerosis...
  46. ncbi Personal exposure to airborne dust and microorganisms in agricultural environments
    Shu An Lee
    Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio 45267 0056, USA
    J Occup Environ Hyg 3:118-30. 2006
    ..Overall, the combined exposure to airborne dust and microorganisms was found to be more severe during harvesting than in animal confinements...
  47. ncbi Size selective dustiness and exposure; simulated workplace comparisons
    Derk H Brouwer
    TNO Quality of Life, Food and Chemical Risk Analysis PO Box 360, 3700 AJ Zeist, The Netherlands
    Ann Occup Hyg 50:445-52. 2006
    A simulated workplace study was conducted to investigate the relation between inhalation exposure and dustiness determined with a rotating drum dustiness tester. Three powders were used in the study, i.e...
  48. pmc Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways
    Amie K Lund
    Lovelace Respiratory Research Institute, Department of Toxicology, Albuquerque, NM 87108, USA
    Arterioscler Thromb Vasc Biol 29:511-7. 2009
    ....
  49. ncbi An evaluation model for syndromic surveillance: assessing the performance of a temporal algorithm
    David L Buckeridge
    Palo Alto Veterans Health Care, Palo Alto, California, USA
    MMWR Morb Mortal Wkly Rep 54:109-15. 2005
    ..Despite considerable experience with implementing syndromic surveillance, limited evidence exists to describe the performance of syndromic surveillance systems in detecting outbreaks...
  50. ncbi Evaluation of the direct systemic and cardiopulmonary effects of diesel particles in spontaneously hypertensive rats
    Abderrahim Nemmar
    Department of Physiology, United Arab Emirates University, Al Ain, United Arab Emirates
    Toxicology 262:50-6. 2009
    ..We conclude that, in SHR, the presence of DEP in the systemic circulation leads not only to cardiac and systemic changes, but also triggers pulmonary inflammatory reaction involving IL-6, LTB4 and oxidative stress...
  51. ncbi Improved biomass stove intervention in rural Mexico: impact on the respiratory health of women
    Isabelle Romieu
    Environmental Health Department, National Institute of Public Health INSP, Cuernavaca, Morelos, Mexico
    Am J Respir Crit Care Med 180:649-56. 2009
    ..Exposure to biomass smoke has been related to adverse health effects. In Mexico, one household in four still cooks with biomass fuel, but there has been no evaluation of the health impact of reducing indoor air pollution...
  52. ncbi Longitudinal lung function decline and wood dust exposure in the furniture industry
    G Jacobsen
    Dept of Occupational Medicine, Region Hospital Skive, Denmark
    Eur Respir J 31:334-42. 2008
    ..In conclusion, in the present low-exposed cohort, female woodworkers had an accelerated decline in lung function, which may be clinically relevant...
  53. pmc Risks from accidental exposures to engineered nanoparticles and neurological health effects: a critical review
    Myrtill Simko
    Austrian Academy of Sciences, Institute of Technology Assessment, Vienna, Austria
    Part Fibre Toxicol 7:42. 2010
    ..Crucial deficits include lack of exposure data, the absence of a proper dose concept, and that studies often fail in adequate description of the investigated ENPs...
  54. ncbi Estimation and correlation of cigarette smoke exposure in Canadian smokers as determined by filter analysis and biomarkers of exposure
    André Morin
    Imperial Tobacco Canada Limited, Montreal, Canada
    Regul Toxicol Pharmacol 61:S3-12. 2011
    ..No consistent dose response, in line with ISO tar yield smoked, of MLE estimates was found for nicotine, pyrene and acrolein and respective biomarkers. The influence of demographics on our results has also been examined...
  55. ncbi Hydrogen sulfide and particle matter levels associated with increased dispensing of anti-asthma drugs in Iceland's capital
    Hanne Krage Carlsen
    Centre of Public Health Sciences, School of Health Sciences, University of Iceland, Stapi v Hringbraut, 101 Reykjavik, Iceland
    Environ Res 113:33-9. 2012
    ..Respiratory health effects of exposure to PM and traffic pollutants are well documented, yet this is one of the first studies to investigate short-term health effects of ambient H2S exposure...
  56. ncbi Nanoparticle-rich diesel exhaust affects hippocampal-dependent spatial learning and NMDA receptor subunit expression in female mice
    Tin Tin Win-Shwe
    Center for Environmental Risk Research, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, Japan
    Nanotoxicology 6:543-53. 2012
    ..These results indicate that three months of exposure to NRDE affected spatial learning and memory function-related gene expressions in the female mouse hippocampus...
  57. ncbi Hazard assessments of manufactured nanomaterials
    Yasuo Morimoto
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Yahatanishiku, Iseigaoka 1 1, Fukuoka, Japan
    J Occup Health 52:325-34. 2010
    ..It has been difficult to make reliable hazard assessments of manufactured nanomaterials, because the nanomaterials form large agglomerations in both in vitro and in vivo studies...
  58. pmc Sampling port for real-time analysis of bioaerosol in whole body exposure system for animal aerosol model development
    Divey Saini
    Duke Human Vaccine Institute, PO Box 103020, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Pharmacol Toxicol Methods 63:143-9. 2011
    ..Measurement of viable aerosol concentration and particle size is essential to optimize viability and lung delivery. The Madison chamber is widely used to expose small animals to infectious aerosols...
  59. ncbi Short term inhalation toxicity of a liquid aerosol of CdS/Cd(OH)₂ core shell quantum dots in male Wistar rats
    L Ma-Hock
    BASF SE, Experimental Toxicology and Ecology, 67056 Ludwigshafen, Germany
    Toxicol Lett 208:115-24. 2012
    ..There was no evidence that QD were translocated to the central nervous system nor that a systemic acute phase response occurred...
  60. ncbi Health effects of welding
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road M S 2015, Morgantown, WV 26505, USA
    Crit Rev Toxicol 33:61-103. 2003
    ..Therefore, an understanding of possible adverse health effects of exposure to welding fumes is essential to risk assessment and the development of prevention strategies and will impact a large population of workers...
  61. ncbi Maternal inhalation of surface-coated nanosized titanium dioxide (UV-Titan) in C57BL/6 mice: effects in prenatally exposed offspring on hepatic DNA damage and gene expression
    Petra Jackson
    National Research Centre for the Working Environment, DK 2100 Copenhagen Ø, Denmark
    Nanotoxicology 7:85-96. 2013
    ..comet assay in bronchoalveolar lavage (BAL) cells and livers of the time-mated mice (5 and 26-27 days after inhalation exposure), and in livers of the offspring (post-natal days (PND) 2 and 22)...
  62. ncbi Quantification of the pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite-asbestos following short-term inhalation exposure
    D M Bernstein
    Consultant in Toxicology, Geneva, Switzerland
    Inhal Toxicol 23:372-91. 2011
    ..These results provide confirmation of the important differences between CSP and amphibole asbestos...
  63. ncbi Lessons from air pollution epidemiology for studies of engineered nanomaterials
    Annette Peters
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology II, Neuherberg, Germany
    J Occup Environ Med 53:S8-S13. 2011
    ..This article discusses evidence from epidemiological studies on air pollution for assessing engineered nano-sized particles in workplace environments...
  64. ncbi Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats
    James M Antonini
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 223:234-45. 2007
    ..Additional chronic inhalation studies are needed to further examine the lung effects associated with SS welding fume exposure...
  65. pmc Differences in the biokinetics of inhaled nano- versus micrometer-sized particles
    Wolfgang G Kreyling
    Comprehensive Pneumology Center Institute of Lung Biology and Disease and Focus Network Nanoparticles and Health, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Acc Chem Res 46:714-22. 2013
    ..Instead, chronic particle inhalation could trigger or modulate the autonomous nervous system or the release of soluble mediators into circulation leading to adverse health effects...
  66. ncbi Inhalation studies for the safety assessment of nanomaterials: status quo and the way forward
    Robert Landsiedel
    BASF Experimental Toxicology and Ecology, Ludwigshafen, Germany
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 4:399-413. 2012
    ..For carcinogenic and cardiovascular effects, research studies are needed to verify-or disprove-the relevance and the mechanisms by which NMs contribute to these effects...
  67. ncbi Acute respiratory distress associated with inhaled hydrocarbon
    Kathryn W Weibrecht
    Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Ind Med 54:911-4. 2011
    ..There are few data about acute pulmonary toxicity from unintentional hydrocarbon inhalation; most human cases involve products containing a fluoropolymer in combination with hydrocarbons...
  68. pmc Controlled human wood smoke exposure: oxidative stress, inflammation and microvascular function
    Lykke Forchhammer
    Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark
    Part Fibre Toxicol 9:7. 2012
    ..We investigated effects on systemic inflammation, oxidative stress and microvascular function (MVF) after controlled wood smoke exposure...
  69. pmc Circulating factors induce coronary endothelial cell activation following exposure to inhaled diesel exhaust and nitrogen dioxide in humans: evidence from a novel translational in vitro model
    Meghan M Channell
    Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Toxicol Sci 127:179-86. 2012
    ..These functional translational assays offer novel approaches to assessing the cardiovascular risk associated with air pollution exposure...
  70. ncbi Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicol Lett 204:12-6. 2011
    ..These results complement epidemiological and functional human studies that suggest welding may result in adverse cardiovascular effects...
  71. ncbi Toxicological evaluation of lung responses after intratracheal exposure to non-dispersed titanium dioxide nanorods
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:790-810. 2011
    ..To summarize, non-dispersed TiO₂ nanorods were found to induce radical formation and cellular oxidant production, and to generate transient and reversible pneumotoxic effects, and to not markedly alter pulmonary immune function...
  72. pmc Characterization and deposition of respirable large- and small-particle bioaerosols
    Richard J Thomas
    Defence Science and Technology Laboratory, Salisbury, Wiltshire, United Kingdom
    Appl Environ Microbiol 74:6437-43. 2008
    ..The aerosols generated by the Collison nebulizer and the FFAG differ with respect to mass distribution, distribution of the entrapped particulates, bacterial survival, and deposition within the murine respiratory tract...
  73. ncbi Exposure to thoracic dust, airway symptoms and lung function in cement production workers
    K C Nordby
    National Institute of Occupational Health, PO Box 8149 Dep, NO 0033 Oslo, Norway
    Eur Respir J 38:1278-86. 2011
    ..The results support the hypothesis that exposure to dust in cement production may lead to respiratory symptoms and airway obstruction...
  74. ncbi Exposure to wood smoke particles produces inflammation in healthy volunteers
    Andrew J Ghio
    The National Health and Environmental Effects Research Laboratory, US EPA, Research Triangle Park, North Carolina, USA
    Occup Environ Med 69:170-5. 2012
    ..This investigation tested the postulate that healthy volunteers exposed to WSP would demonstrate evidence of both pulmonary and systemic inflammation...
  75. pmc The Diesel Exhaust in Miners Study: II. Exposure monitoring surveys and development of exposure groups
    Joseph B Coble
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:747-61. 2010
    ....
  76. pmc Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue
    Xiaohua Xu
    Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Toxicol Sci 124:88-98. 2011
    ..These findings suggest that long-term ambient PM₂.₅ exposure induces impaired glucose tolerance, IR, inflammation, and mitochondrial alteration, and thus, it is a risk factor for the development of type 2 diabetes...
  77. ncbi Human health effects of air pollution
    Marilena Kampa
    Laboratory of Experimental Endocrinology, University of Crete, School of Medicine, Heraklion, Greece
    Environ Pollut 151:362-7. 2008
    ..In addition, short- and long-term exposures have also been linked with premature mortality and reduced life expectancy. These effects of air pollutants on human health and their mechanism of action are briefly discussed...
  78. ncbi Aerosol exposure to the angola strain of marburg virus causes lethal viral hemorrhagic Fever in cynomolgus macaques
    D A Alves
    Center for Vaccine Research, University of Pittsburgh, 8037 BST3, 3051 Fifth Avenue, Pittsburgh, PA 15261, USA
    Vet Pathol 47:831-51. 2010
    ..These macaques exhibited a number of features similar to those of human filovirus infections; as such, this model of aerosolized MARV-Angola might be useful in developing medical countermeasures under the Animal Rule...
  79. ncbi Diesel exhaust inhalation does not affect heart rhythm or heart rate variability
    Nicholas L Mills
    Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK
    Heart 97:544-50. 2011
    ..This study was undertaken to determine the effect of diesel exhaust inhalation on heart rhythm and heart rate variability in healthy volunteers and patients with coronary heart disease...
  80. ncbi The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes
    Stephan Gebel
    Philip Morris Research Laboratories GmbH, Philip Morris International Research and Development, Koln, Germany
    Toxicol Sci 115:238-52. 2010
    ....
  81. pmc Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK
    Qinghua Sun
    Division of Environmental Health Sciences, Davis Heart Lung Research Institute, Colleges of Medicine and Public Health, The Ohio State University, Columbus, OH 43210 1252, USA
    Arterioscler Thromb Vasc Biol 28:1760-6. 2008
    ..Fine particulate matter <2.5 microm (PM(2.5)) has been implicated in vasoconstriction and potentiation of hypertension in humans. We investigated the effects of short-term exposure to PM(2.5) in the angiotensin II (AII) infusion model...
  82. ncbi Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound
    Melvin E Andersen
    Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 118:716-31. 2010
    ....
  83. ncbi Trends in inhalation exposure--a review of the data in the published scientific literature
    Karen S Creely
    Research Division, Institute of Occupational Medicine, Research Avenue North, Riccarton, Edinburgh, UK
    Ann Occup Hyg 51:665-78. 2007
    As part of a larger study aimed at identifying the long-term changes in inhalation exposure for selected hazardous substances in a number of industrial sectors within the UK, we have reviewed the published literature on temporal changes ..
  84. pmc Design, assembly, and validation of a nose-only inhalation exposure system for studies of aerosolized viable influenza H5N1 virus in ferrets
    Richard S Tuttle
    Aerosol Research and Engineering Laboratories, 13300 West 98th Street, Lenexa, Kansas 66215, USA
    Virol J 7:135. 2010
    ..whether H5N1 viruses are transmissible by aerosol in an animal model that is a surrogate for humans, an inhalation exposure system for studies of aerosolized H5N1 viruses in ferrets was designed, assembled, and validated...
  85. ncbi Personal child and mother carbon monoxide exposures and kitchen levels: methods and results from a randomized trial of woodfired chimney cookstoves in Guatemala (RESPIRE)
    Kirk R Smith
    Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720 7360, USA
    J Expo Sci Environ Epidemiol 20:406-16. 2010
    ....
  86. pmc A biopersistence study following exposure to chrysotile asbestos alone or in combination with fine particles
    D M Bernstein
    University of Edinburgh, ELEGI Colt Laboratory, Edinburgh, Scotland
    Inhal Toxicol 20:1009-28. 2008
    ..The increased number of macrophages in the chrysotile/sanded joint exposure group was confirmed histologically, with this being the only exposure-related histological finding reported...
  87. ncbi The pathological response and fate in the lung and pleura of chrysotile in combination with fine particles compared to amosite asbestos following short-term inhalation exposure: interim results
    D M Bernstein
    Inhal Toxicol 22:937-62. 2010
    ....
  88. ncbi Characteristics of asbestos concentration in lung as compared to asbestos concentration in various levels of lymph nodes that collect drainage from the lung
    Ronald F Dodson
    Dodson Environmental Consulting, Inc and ERI Analytical, Tyler, Texas, USA
    Ultrastruct Pathol 31:95-133. 2007
    ..When a long/thin fiber was found in the lung or lymph tissue, its detection required the use of analytical transmission electron microscopy for identification...
  89. pmc An animal model of cigarette smoke-induced in utero growth retardation
    Emily R Esposito
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, ULSD, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    Toxicology 246:193-202. 2008
    ..animal model of cigarette smoke-induced in utero growth retardation and LBW using physiologically relevant inhalation exposure conditions which simulate "active" and "passive" tobacco smoke exposures, and (2) to determine whether ..
  90. ncbi Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Neurotoxicology 30:915-25. 2009
    ..The neurofunctional significance of these findings currently is being investigated in longer, more chronic welding fume exposure studies...
  91. ncbi The automated bioaerosol exposure system: preclinical platform development and a respiratory dosimetry application with nonhuman primates
    Justin M Hartings
    Hartings Consulting, Inc, USA
    J Pharmacol Toxicol Methods 49:39-55. 2004
    Well-characterized inhalation exposure systems are critical for preclinical testing and pathogenesis studies...
  92. ncbi Changes in lung function and airway inflammation among asthmatic children residing in a woodsmoke-impacted urban area
    Ryan W Allen
    Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada
    Inhal Toxicol 20:423-33. 2008
    ..5), whereas airway inflammation may be more closely related to some other constituent of the ambient PM(2.5) mixture...
  93. pmc Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study
    ROBIN C PUETT
    South Carolina Cancer Prevention and Control Program and Department of Epidemiology, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29201, USA
    Environ Health Perspect 117:1697-701. 2009
    ..5 and 10 microm (PM(10-2.5)), may also be important. With respect to mortality and cardiovascular events, questions remain regarding the relative strength of effect sizes for chronic exposure to fine and coarse particles...
  94. ncbi Ambient air pollution exposure, residential mobility and term birth weight in Oslo, Norway
    Christian Madsen
    Division of Epidemiology, Norwegian Institute of Public Health, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Environ Res 110:363-71. 2010
    ..However, mobility patterns could introduce possible confounding when examining small-scale variations in exposure by using addresses. This could be of importance in future studies...
  95. ncbi Testing strategies to establish the safety of nanomaterials: conclusions of an ECETOC workshop
    David B Warheit
    DuPont, Haskell Laboratory, Newark, Delaware 19714 0050, USA
    Inhal Toxicol 19:631-43. 2007
    ..However, it has become clear that these topics should be the subjects of separate workshops and they are not further addressed in this report...
  96. pmc The Diesel Exhaust in Miners Study: IV. Estimating historical exposures to diesel exhaust in underground non-metal mining facilities
    Roel Vermeulen
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:774-88. 2010
    ..These REC exposure estimates were in a plausible range and were used in the investigation of exposure-response relationships in epidemiologic analyses...
  97. pmc Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice
    L A Mitchell
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    Nat Nanotechnol 4:451-6. 2009
    ..Our findings suggest that signals from the lung can activate signals in the spleen to suppress the immune function of exposed mice...
  98. pmc Formaldehyde exposure and asthma in children: a systematic review
    Gerald McGwin
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Environ Health Perspect 118:313-7. 2010
    ..Here we report the results of a systematic review of published literature in order to provide a more comprehensive picture of this relationship...
  99. ncbi Biological effects of particles from the paris subway system
    Rafik Bachoual
    INSERM, U700 Université Paris 7 Denis Diderot, site Bichat, and Biochimie B, Assistance Publique Hopitaux de Paris, Hopital Bichat, Paris, France
    Chem Res Toxicol 20:1426-33. 2007
    ..PM from the Paris subway system has transient biological effects. Further studies are needed to better understand the pathophysiological implications of these findings...
  100. pmc Air pollution exposure during pregnancy and reduced birth size: a prospective birth cohort study in Valencia, Spain
    Ferran Ballester
    Center for Public Health Research CSISP, Conselleria de Sanitat, 46020, Valencia, Spain
    Environ Health 9:6. 2010
    ..The objective of this study was to assess the association between exposure to air pollution during pregnancy and anthropometric measures at birth in a cohort in Valencia, Spain...
  101. pmc Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease
    Nicholas L Mills
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 116:709-15. 2008
    ..Exposure to fine particulate air pollution is associated with increased cardiovascular morbidity and mortality. We previously demonstrated that exposure to dilute diesel exhaust causes vascular dysfunction in humans...

Research Grants63

  1. Pulmonary effects of biomass fuel indoor PM from rural India
    Shyam Biswal; Fiscal Year: 2013
    ..Although an inhalation exposure model is more realistic, airway instillation has been demonstrated to be a very effective model for ..
  2. Diesel Exhaust Particle Effects on Human Immunity to Mycobacterium tuberculosis
    Stephan K Schwander; Fiscal Year: 2010
    ..Our unique preliminary studies in healthy volunteers after DEP inhalation exposure show increased M.tb-induced IFN-gamma, and decreased M.tb-induced IL-6 and IL-10 release...
  3. Biomimetic Microsystem for High Throughput Evaluation of Engineered Nanomaterials
    Robert M Worden; Fiscal Year: 2010
    ..Due to their small size and potential for airborne dispersion, inhalation exposure to ENM might contribute to the increased incidence and/or exacerbation of allergic airway disease...
  4. Hazard Assessment and Risk Estimation of Inhaled Nanomaterials Exposure
    Gunter Oberdorster; Fiscal Year: 2010
    ..tract and to quantitate ENM translocation- related effects in secondary tissues following realistic inhalation exposure using a multidisciplinary tiered testing approach...
  5. DNA cross-linking by diepoxybutane
    Natalia Y Tretyakova; Fiscal Year: 2013
    ..Quantify bifunctional DEB-DNA lesions in vivo following inhalation exposure to 1,3-butadiene...
  6. Microvascular Health and Nanoparticle Exposure
    Timothy R Nurkiewicz; Fiscal Year: 2010
    ..Concurrently, we are the only laboratory in this area/topic to directly evaluate microvascular health after inhalation exposure to such nanoparticles...
  7. Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect Ag
    YVONNE J ROSENBERG; Fiscal Year: 2012
    ..the OP's entry into the systemic circulation and avoiding the respiratoty usually associated with inhalation exposure. Phase I represents a feasibility study in mice to examine (i) the patterns of deposition of either liquid ..
  8. Research on inhalation toxicology of environmental chemicals
    ROBERT O apos CONNER; Fiscal Year: 2010
    Keywords inhalation exposure;oropharyngeal aspiration;ozone;lipopolysaccharide;hyperoxia;vanadium pentoxide;bleomycin, pulmonary function;ovalbumin, cigarette smoke, diacetyl, 2,3-pentanedione, benzene...
  9. Research on inhalation toxicology of environmental chemicals
    ROBERT O'CONNER; Fiscal Year: 2011
    Keywords inhalation exposure;oropharyngeal aspiration;ozone;lipopolysaccharide;hyperoxia;vanadium pentoxide;bleomycin, pulmonary function;ovalbumin, cigarette smoke, diacetyl, 2,3-pentanedione, benzene...
  10. Mechansims of Lung Carcinogenesis Induced by Asbestos and Cigarette Smoke
    Deborah E Sullivan; Fiscal Year: 2012
    ..will determine lung tumorigenesis in wild-type and p53R172H (a dominant negative mutant) knockin mice after inhalation exposure to asbestos and cigarette smoke...
  11. UC Davis California National Primate Research Center Respiratory Disease Center
    DALLAS MELVIN HYDE; Fiscal Year: 2010
    ..gross square foot (GSF) Respiratory Diseases Center (RDC) that includes office and laboratory space, an inhalation exposure facility, animal holding space, and a laboratory space for pulmonary function testing...
  12. EFFECTS OF INHALED FLORIDA RED TIDE BREVETOXINS
    Daniel G Baden; Fiscal Year: 2011
    ..The investigators shall further characterize inhalation exposure to the complex mixture of materials aerosolized from red tide, depositing in occupational, recreational, ..
  13. Orbitofrontal Cortex Dysfunction After Chronic Ethanol Exposure
    Kimberly A Badanich; Fiscal Year: 2011
    ..conducted during the first (days 4-9) or second (days 11-16) week following the last bout of EtOH (or air) inhalation exposure. It is expected that alcohol dependent mice will show dose-dependent deficits in set-shifting and reversal ..
  14. Research on inhalation toxicology of environmental chemicals
    ROBERT O apos CONNER; Fiscal Year: 2009
    Keywords inhalation exposure;oropharyngeal aspiration;ozone;lipopolysaccharide;hyperoxia;vanadium pentoxide;bleomycin, pulmonary function;ovalbumin, cigarette smoke...
  15. Investigating Health Effects From Exposure to Organic Carbon and Nickel Aerosol
    Richard E Peltier; Fiscal Year: 2013
    ..This research involves a series of in-vivo inhalation exposure studies using a murine model of cardiovascular disease...
  16. Vascular Consequences of Multi-Walled Carbon Nanotube Exposure
    PHOEBE STAPLETON; Fiscal Year: 2013
    ..endothelium-dependent microvascular dysfunction of the coronary arterioles persists up to 168-hours after inhalation exposure. The present study proposes exposing rats to MWCNT via routes typically experienced in occupational and ..
  17. A unique mouse model for studying immunity to virulent Franciscella infections
    Gary R Klimpel; Fiscal Year: 2010
    ..is known about how mice respond to virulent Francisella Type A strains (SCHU S4) with regard to immunity to inhalation exposure. There are few studies of virulent Type A strains of Francisella using mice and/or in mice exposed via ..
  18. Maternal Nanomaterial Exposures: Fetal Microvascular Endpoints and Programming
    Timothy R Nurkiewicz; Fiscal Year: 2013
    ..Three specific aims will be completed in rats with ENM inhalation exposure, intravital microscopy, isolated arterioles, transcriptomics and epigenetics...
  19. Novel Therapies for Enhancing Clearance of Inhaled Radioactive Particles
    KARL H DONN; Fiscal Year: 2010
    ..and development project with the goal of advancing a therapeutic countermeasure for radiological material inhalation exposure through the product development process...
  20. Semi-volatile PCBs: Sources, Exposures, Toxicities
    Larry W Robertson; Fiscal Year: 2013
    ..such as conjugation with thiols, affect this reactivity;4) Analyze the genotoxicity of airborne PCBs after inhalation exposure and explore mechanisms to ameliorate/mediate against those effects...
  21. Prospective Study of Biofilms, Mycobacteria and Pseudomonads in Metalworking Flui
    Chuanwu Xi; Fiscal Year: 2010
    ..Ultimately, this would serve to reduce the risk of adverse health events related to inhalation exposure to microbes or microbial products in MWFs...
  22. Therapeutics against chemical threat induced respiratory toxicity
    MADHUSOODANA NAMBIAR; Fiscal Year: 2009
    ..We propose to investigate the respiratory toxicity and lung injury following inhalation exposure to the deadly chemical threat agent sarin in animal models...
  23. Dual Antigen Nanoparticle Vaccine System For Bacillus Infectious Disease
    Puthupparampil Scaria; Fiscal Year: 2009
    ..and provide protection from challenge with Anthrax toxin and, if successful, investigate protection from inhalation exposure to bacterial spores...
  24. Studies to evaluate the tox and carcinogentic potential of test articles
    MILTON D HEJTMANCIK; Fiscal Year: 2011
    ..studies of the chemical intermediate p-chloro-a,a,a-trifluorotoluene have been issued and is in the inhalation exposure/generation development and chemistry phase...
  25. Biomarkers for exposure to Stachybotrys
    Dorr Dearborn; Fiscal Year: 2007
    ..Attempts to relate inhalation exposure to pulmonary, immune and neurological toxicities have had only circumstantial evidence supporting the ..
  26. STUDIES TO EVALUATE THE TOXIC AND CARCINOGENIC POTENTIAL
    Jeffrey Dill; Fiscal Year: 2009
    ..Cobalt metal 14 and 90 day as well as 2-year studies have been reported. Keywords Carcinogenicity;Toxicity;Bioassay;F344 rats;B6C3F1 mice;inhalation exposure;1-Bromopropane;Cobalt metal;Diethylamine;Triethylamine.
  27. INHALED PARTICLE CHARACTERISTICS AND EARLY LUNG EFFECTS
    William Beckett; Fiscal Year: 2002
    ..lung and systemic inflammatory responses as well as cardiac effects in adults after carefully controlled inhalation exposure to ultrafine and accumulation mode zinc oxide, a particle we have previously characterized for the dose-..
  28. Prenatal Insecticide Exposures Among Urban Minorities
    Robin Whyatt; Fiscal Year: 2005
    ..dust and personal air samples collected from the mothers during the 3rd trimester as a dosimeter of use and inhalation exposure; and (3) measure levels of the replacement insecticides in urine and umbilical cord blood samples collected ..
  29. RESPIRATORY ANAPHYLAXIS TO INDUSTRIAL CHEMICALS
    MERYL KAROL; Fiscal Year: 1991
    ..Each of these components will be evaluated in inbred strain #2 guinea pigs sensitized to ovalbumin by inhalation exposure. Airway hyperreactivity will be artifically produced by exposure of animals to 1 ppm ozone...
  30. P53 IN ASBESTOS INDUCED LUNG DISEASE
    Gilbert Morris; Fiscal Year: 2000
    ..p53-mediated control of cell proliferation is central to the development of pulmonary fibrosis following inhalation exposure to asbestos and that p53 regulates transcription of PCNA, an essential DNA replication and repair protein, ..
  31. Neural Control of Airway Responses in Early Life
    RICHARD DEY; Fiscal Year: 2009
    ..airways continues to develop during the early postnatal period, and our preliminary studies suggest that inhalation exposure to airway irritants during this period permanently alters normal development of airway innervation and ..
  32. O3 AND MODULATING CR TOXICITY AND THE LUNG
    Judith Zelikoff; Fiscal Year: 2001
    ..In this regard, chromium (Cr) is released with ozone (O3) during welding, and a major health hazard from inhalation exposure to Cr-containing materials is lung cancer; this is likely due largely to the insoluble Cr species in the ..
  33. LUNG METABOLISM & TOXICITY OF ENVIRONMENTAL ARSENICALS
    DEAN CARTER; Fiscal Year: 1993
    Arsenic (As) is an important environmental toxin which is toxic to the lung after inhalation exposure, however, the interaction between inorganic arsenic and the lung has not been examined in any detail...
  34. Therapeutic Targeting of the Infectious Path of Anthrax
    ANTHONY SCOTTO; Fiscal Year: 2003
    ..Lastly, in the aftermath of a widespread inhalation exposure to anthrax we expect that a highly targeted SLIT-ciprofloxacin will address the need for a rapid, easily ..
  35. Effect of Diesel Exhaust Particles on DNA Deletions
    ROBERT SCHIESTL; Fiscal Year: 2006
    ..We have also previously shown that inhalation exposure to cigarette smoke for only four hours producing a blood nicotine level that is similar to what a smoker ..
  36. IMMUNOTOXICITY OF ABUSED NITRITE INHALANTS
    Lee Soderberg; Fiscal Year: 2000
    ..Since previous studies indicated that inhalation exposure to the nitrites enhanced the production, but not transcription of the cytokine, tumor necrosis factor-alpha ..
  37. Isocyanate Exposure Intervention Study in Body Shops
    Youcheng Liu; Fiscal Year: 2004
    ..Our preliminary data revealed a high inhalation exposure to isocyanate oligomers and extensive skin exposure in auto body shop workers...
  38. INHALATION TOXICOLOGY OF ENVIRONMENTAL CHEMICALS
    ROBERT O CONNOR; Fiscal Year: 2000
    This contract provides inhalation exposure capability for the research program of the National Toxicology Program and the intramural research program of the National Institute of Environmental Health Sciences (NIEHS)...
  39. Particle kinetics in the postnatally developing lung
    Akira Tsuda; Fiscal Year: 2007
    ..3) Excised lungs of developing piglets at different stages of alveolation will be used to do inhalation exposure and flow visualization experiments...
  40. Development of a Highly Efficient Personal Sampler to collect Viable Bioaerosols
    Yung Sung Cheng; Fiscal Year: 2010
    ..The new device will not only be beneficial in occupational settings, but may also have future potential in high risk areas such as those following any possible biological attack. ..
  41. Inhalation Dosimetry/Exposure Index of Fiber Aerosol
    Yung Sung Cheng; Fiscal Year: 2006
    ..Sampling devices based on this size-selection definition can be developed in the future for improved assessment of worker exposure. ..
  42. A Preclinical Model of Adolescent Toluene Abuse in Rats
    Scott Bowen; Fiscal Year: 2005
    ..The model also has the potential to assist in devising effective treatments and prevention strategies for adolescent inhalant abuse. ..
  43. Behavioral Effects of Gestational Inhalant Abuse in Rats
    Scott Bowen; Fiscal Year: 2006
    ..Finally, this research has the potential to assist in the design of effective treatments for inhalant abuse. [unreadable] [unreadable]..
  44. Exposure Intervention in a Rural Pediatric Asthma Cohort
    Peter Thorne; Fiscal Year: 2005
    ..Detailed health and home hygiene questionnaires and home inspections will be conducted at baseline and one year later, as will child spirometry. ..
  45. Self-administration of abused inhalants in mice
    Scott Bowen; Fiscal Year: 2004
    ....
  46. Ultrafine Particle Exposure in Humans
    Mark Frampton; Fiscal Year: 2005
    ..These studies will identify key mechanisms for the cardiovascular effects of exposure to ambient air particles. ..
  47. Nasal dosimetry of diacetyl and butyric acid vapors
    John Morris; Fiscal Year: 2005
    ..It has recently been shown that inhalation exposure of the rat to butter flavoring vapors results in necrosis of the nasal, bronchial and bronchiolar airways...
  48. NEW METHODS FOR EVAL OF ORGANIC DUST AEROSOLS
    Stephen Reynolds; Fiscal Year: 2006
    ....
  49. SCANNING ELECTRON MICROSCOPY SYSTEM
    John Godleski; Fiscal Year: 2001
    ..Institutional support is demonstrated by past support of the facility, completed renovations, commitments for ongoing service contracts, and letters of commitment for future support. ..
  50. INDUSTRIAL HYGIENE TRAINING PROGRAM - ERGONOMICS SUPPLEMENT
    Stephen Reynolds; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  51. Ultrafine Particle-Induced Oxidative Stress
    Mark Frampton; Fiscal Year: 2007
    ..abstract_text> ..
  52. Cardiac vulnerability due to ambient particulate
    John Godleski; Fiscal Year: 2008
    ..Thus, the present application will entail unique application of comprehensive techniques to improve understanding of the mechanisms whereby CAPs can exert its deleterious influences on the heart and circulation [unreadable] [unreadable]..
  53. Development of SAMMA based vaginal microbiocide
    Michael Oldham; Fiscal Year: 2006
    ..3. EFFICACY. The new formulations will also be evaluated for activity against sperm, chlamydia and HSV utilizing in vitro assays and the mouse model. [unreadable] [unreadable] [unreadable]..
  54. Workplace Aerosol Sampling at Realistic Low Windspeeds
    James Vincent; Fiscal Year: 2006
    ..The new research will fill these gaps and place occupational aerosol exposure assessment on a still firmer footing. ..
  55. CONFERENCE ON PARTICULATE AIR POLLUTION AND HUMAN HEALTH
    Robert Phalen; Fiscal Year: 2003
    ..To add significantly to the peer-reviewed literature by publishing research results presented at the conference in a variety of special issues of selected journals. ..
  56. Occupational Medicine Activities and Skills: An Empiric Study
    Philip Harber; Fiscal Year: 2009
    ..Analyses will be both descriptive and address specific questions such as determining the impact of formal education and evaluating whether occupational preventive medicine is a homogeneous field or composed of distinct subgroups. ..
  57. Innovative Interventions for Smoking Cessation
    Dorothy K Hatsukami; Fiscal Year: 2010
    ..The results of this study will provide useful information on directions to pursue to improve our pharmacotherapies and behavioral treatments and to better understand the various aspects of addiction. ..
  58. The link between lipid peroxidation and manganese induced glutathione depletion
    Keith Erikson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  59. Maternal Influence in the Development of Asthma
    Edward Barrett; Fiscal Year: 2008
    ..This application will provide new insight into the underlying mechanisms that contribute to the development of asthma and identify new targets for preventative therapies. ..