environmental exposure

Summary

Summary: The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.

Top Publications

  1. pmc Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
    Laura N Vandenberg
    Tufts University, Center for Regenerative and Developmental Biology, Department of Biology, 200 Boston Avenue, Suite 4600, Medford, Massachusetts 02155, USA
    Endocr Rev 33:378-455. 2012
  2. pmc Distributed lag non-linear models
    A Gasparrini
    Public Health and Policy Department, London School of Hygiene and Tropical Medicine, Keppel Street, London W1C 7HT, U K
    Stat Med 29:2224-34. 2010
  3. ncbi Environmental epigenomics and disease susceptibility
    Randy L Jirtle
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Genet 8:253-62. 2007
  4. pmc Air pollution and incidence of hypertension and diabetes mellitus in black women living in Los Angeles
    Patricia F Coogan
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Ave, Boston, MA 02215, USA
    Circulation 125:767-72. 2012
  5. ncbi Human exposure to bisphenol A (BPA)
    Laura N Vandenberg
    Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111, USA
    Reprod Toxicol 24:139-77. 2007
  6. pmc The Comparative Toxicogenomics Database: update 2011
    Allan Peter Davis
    Department of Bioinformatics, The Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA
    Nucleic Acids Res 39:D1067-72. 2011
  7. ncbi Developmental neurotoxicity of industrial chemicals
    P Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Lancet 368:2167-78. 2006
  8. pmc Exposure measurement error in time-series studies of air pollution: concepts and consequences
    S L Zeger
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 108:419-26. 2000
  9. pmc Environmental chemicals in pregnant women in the United States: NHANES 2003-2004
    Tracey J Woodruff
    Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Oakland, California 94612, USA
    Environ Health Perspect 119:878-85. 2011
  10. ncbi Endocrine disruptors: from endocrine to metabolic disruption
    Cristina Casals-Casas
    Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Switzerland
    Annu Rev Physiol 73:135-62. 2011

Detail Information

Publications392 found, 100 shown here

  1. pmc Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
    Laura N Vandenberg
    Tufts University, Center for Regenerative and Developmental Biology, Department of Biology, 200 Boston Avenue, Suite 4600, Medford, Massachusetts 02155, USA
    Endocr Rev 33:378-455. 2012
    ..Thus, fundamental changes in chemical testing and safety determination are needed to protect human health...
  2. pmc Distributed lag non-linear models
    A Gasparrini
    Public Health and Policy Department, London School of Hygiene and Tropical Medicine, Keppel Street, London W1C 7HT, U K
    Stat Med 29:2224-34. 2010
    ....
  3. ncbi Environmental epigenomics and disease susceptibility
    Randy L Jirtle
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Genet 8:253-62. 2007
    ..Methods are now becoming available to investigate the relevance of these phenomena to human disease...
  4. pmc Air pollution and incidence of hypertension and diabetes mellitus in black women living in Los Angeles
    Patricia F Coogan
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Ave, Boston, MA 02215, USA
    Circulation 125:767-72. 2012
    ..Preliminary epidemiological and clinical evidence suggests that air pollution may contribute to the development of hypertension and type 2 diabetes mellitus...
  5. ncbi Human exposure to bisphenol A (BPA)
    Laura N Vandenberg
    Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111, USA
    Reprod Toxicol 24:139-77. 2007
    ..The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models...
  6. pmc The Comparative Toxicogenomics Database: update 2011
    Allan Peter Davis
    Department of Bioinformatics, The Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA
    Nucleic Acids Res 39:D1067-72. 2011
    ..Together, this wealth of expanded chemical-gene-disease data continues to help users generate testable hypotheses about the molecular mechanisms of environmental diseases. CTD is freely available at http://ctd.mdibl.org...
  7. ncbi Developmental neurotoxicity of industrial chemicals
    P Grandjean
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Lancet 368:2167-78. 2006
    ..New, precautionary approaches that recognise the unique vulnerability of the developing brain are needed for testing and control of chemicals...
  8. pmc Exposure measurement error in time-series studies of air pollution: concepts and consequences
    S L Zeger
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 108:419-26. 2000
    ..Finally, we summarize open questions regarding measurement error and suggest the kind of additional data necessary to address them...
  9. pmc Environmental chemicals in pregnant women in the United States: NHANES 2003-2004
    Tracey J Woodruff
    Program on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Oakland, California 94612, USA
    Environ Health Perspect 119:878-85. 2011
    ....
  10. ncbi Endocrine disruptors: from endocrine to metabolic disruption
    Cristina Casals-Casas
    Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Switzerland
    Annu Rev Physiol 73:135-62. 2011
    ..Finally, we discuss the difficulties of fairly assessing the risks linked to EDC exposure, including developmental exposure, problems of high- and low-dose exposure, and the complexity of current chemical environments...
  11. pmc Temporal variability of urinary phthalate metabolite levels in men of reproductive age
    Russ Hauser
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 112:1734-40. 2004
    ..In particular, a single urine sample was most predictive for MEP and least predictive for MEHP. These results suggest that the most efficient exposure assessment strategy for a particular study may depend on the phthalates of interest...
  12. ncbi Hazards of heavy metal contamination
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College, London, UK
    Br Med Bull 68:167-82. 2003
    ..Although lead in petrol has dramatically decreased over the last decades, thereby reducing environmental exposure, phasing out any remaining uses of lead additives in motor fuels should be encouraged...
  13. pmc Reduction in cadmium exposure in the United States population, 1988-2008: the contribution of declining smoking rates
    Maria Tellez-Plaza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room W7513D, Baltimore, MD 21205 USA
    Environ Health Perspect 120:204-9. 2012
    ..S. adults. However, trends in urine cadmium, a marker of cumulative cadmium exposure, have not been evaluated...
  14. ncbi In vitro molecular mechanisms of bisphenol A action
    Yelena B Wetherill
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Reprod Toxicol 24:178-98. 2007
    ....
  15. ncbi Selected major risk factors and global and regional burden of disease
    Majid Ezzati
    Risk, Resources and Environmental Management Division, Resources for the Future, Washington, DC, USA
    Lancet 360:1347-60. 2002
    ..Our aim was to estimate the contributions of selected major risk factors to global and regional burden of disease in a unified framework...
  16. ncbi The National Human Activity Pattern Survey (NHAPS): a resource for assessing exposure to environmental pollutants
    N E Klepeis
    Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA
    J Expo Anal Environ Epidemiol 11:231-52. 2001
    ..In both California and the entire nation, the most time spent exposed to ETS was reported to take place in residential locations...
  17. pmc Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Environ Health Perspect 112:331-8. 2004
    ....
  18. pmc Nitrogen dioxide levels estimated from land use regression models several years apart and association with mortality in a large cohort study
    Giulia Cesaroni
    Department of Epidemiology, Lazio Regional Health Service, Via S, Costanza 53, 00198 Rome, Italy
    Environ Health 11:48. 2012
    ..We aimed to compare measured and estimated NO₂ levels 12 years apart, the stability of the exposure estimates for members of a large cohort study, and the association of the exposure estimates with natural mortality within the cohort...
  19. pmc Cadmium exposure and neurodevelopmental outcomes in U.S. children
    Timothy Ciesielski
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:758-63. 2012
    ..Low-level environmental cadmium exposure in children may be associated with adverse neurodevelopmental outcomes...
  20. ncbi Twenty-four hour human urine and serum profiles of bisphenol a during high-dietary exposure
    Justin G Teeguarden
    Fundamental and Computational Sciences, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Toxicol Sci 123:48-57. 2011
    ..During these high dietary exposures, (TOT)BPA concentrations in serum were undetectable in 83% of the 320 samples collected and BPA concentrations were determined to be less than or equal to LOD in all samples...
  21. pmc Cadmium, environmental exposure, and health outcomes
    Soisungwan Satarug
    Department of Pathology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202, USA
    Environ Health Perspect 118:182-90. 2010
    ..We provide an update of the issues surrounding health risk assessment of exposure to cadmium in food...
  22. pmc Lung cancer and cardiovascular disease mortality associated with ambient air pollution and cigarette smoke: shape of the exposure-response relationships
    C Arden Pope
    Economics Department, Brigham Young University, Provo, Utah, USA
    Environ Health Perspect 119:1616-21. 2011
    ..Comparable estimates of the exposure-response relationship for lung cancer are required for disease burden estimates and related public health policy assessments...
  23. pmc Ambient air pollution and the progression of atherosclerosis in adults
    Nino Kunzli
    Swiss Tropical and Public Health Institute Swiss TPH, Basel, Switzerland University of Basel, Basel, Switzerland corrected
    PLoS ONE 5:e9096. 2010
    ..We investigated the association between outdoor air quality and progression of subclinical atherosclerosis (common carotid artery intima-media thickness, CIMT)...
  24. pmc Epidemiologic evaluation of measurement data in the presence of detection limits
    Jay H Lubin
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Environ Health Perspect 112:1691-6. 2004
    ..We illustrate various approaches using measurements of pesticide residues in carpet dust in control subjects from a case-control study of non-Hodgkin lymphoma...
  25. pmc Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption
    Laura N Vandenberg
    Tufts University School of Medicine, Department of Anatomy and Cellular Biology, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Endocr Rev 30:75-95. 2009
    ....
  26. ncbi GPS tracking in neighborhood and health studies: a step forward for environmental exposure assessment, a step backward for causal inference?
    Basile Chaix
    INSERM, U707, Faculte de Medecine Saint Antoine, 27 rue Chaligny, 75012 Paris, France
    Health Place 21:46-51. 2013
    ..Combining GPS and GIS allows for advances in environmental exposure assessment...
  27. pmc Meeting report: atmospheric pollution and human reproduction
    Remy Slama
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Environ Health Perspect 116:791-8. 2008
    ..There is a growing body of epidemiologic literature reporting associations between atmospheric pollutants and reproductive outcomes, particularly birth weight and gestational duration...
  28. ncbi Assessing exposure to phthalates - the human biomonitoring approach
    Matthias Wittassek
    Chromsystems Instruments and Chemicals GmbH, Munich, Germany
    Mol Nutr Food Res 55:7-31. 2011
    ..Recent findings from animal studies suggest that a cumulative risk assessment for phthalates is warranted, and a cumulative exposure assessment to phthalates via human biomonitoring is a major step into this direction...
  29. pmc Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air
    Carl Elis Boström
    Swedish Environmental Protection Agency, Stockholm, Sweden
    Environ Health Perspect 110:451-88. 2002
    ..Additional source-specific indicators are benzo[ghi]perylene for gasoline vehicles, retene for wood combustion, and dibenzothiophene and benzonaphthothiophene for sulfur-containing fuels...
  30. ncbi Elimination of persistent toxicants from the human body
    Stephen J Genuis
    University of Alberta, 2935 66 Street, Edmonton, Alberta, Canada
    Hum Exp Toxicol 30:3-18. 2011
    ..Potential therapies to circumvent enterohepatic recirculation and a case report highlighting a clinical outcome associated with detoxification are also presented for consideration...
  31. pmc Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 111:201-5. 2003
    ..This study provides evidence that environmental pollutants at levels currently encountered in New York City adversely affect fetal development...
  32. pmc An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis
    Xuefeng Ren
    Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:11-9. 2011
    ..Recent studies have suggested that epigenetic mechanisms may also mediate toxicity and carcinogenicity resulting from arsenic exposure...
  33. pmc Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity
    Qinghua Sun
    Wolfe Professor of Medicine and Radiology, Davis Heart and Lung Research Institute, Room 110, 473 W 12th Ave, Columbus, OH 43210 1252, USA
    Circulation 119:538-46. 2009
    ..We hypothesized that exposure to ambient fine particulate matter (<2.5 mum; PM(2.5)) exaggerates diet-induced insulin resistance, adipose inflammation, and visceral adiposity...
  34. ncbi Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke: shape of the exposure-response relationship
    C Arden Pope
    142 FOB, Brigham Young University, Provo, UT 84602 2363, USA
    Circulation 120:941-8. 2009
    ..This study directly assessed the shape of the exposure-response relationship between cardiovascular mortality and fine particulates from cigarette smoke and ambient air pollution...
  35. ncbi Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life
    Olena Gruzieva
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 129:240-6. 2012
    ..The role of exposure to air pollution in the development of allergic sensitization remains unclear...
  36. pmc Heat-related and cold-related deaths in England and Wales: who is at risk?
    S Hajat
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Occup Environ Med 64:93-100. 2007
    ..Despite the high burden from exposure to both hot and cold weather each year in England and Wales, there has been relatively little investigation on who is most at risk, resulting in uncertainties in informing government interventions...
  37. ncbi Long-term exposure to air pollution and incidence of cardiovascular events in women
    Kristin A Miller
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 356:447-58. 2007
    ..We examined the association of long-term exposure to particulate matter of less than 2.5 microm in aerodynamic diameter (PM2.5) with cardiovascular events...
  38. pmc Fine-particulate air pollution and life expectancy in the United States
    C Arden Pope
    Department of Economics, Brigham Young University, Provo, UT 84602 2363, USA
    N Engl J Med 360:376-86. 2009
    ..This study directly evaluated the changes in life expectancy associated with differential changes in fine particulate air pollution that occurred in the United States during the 1980s and 1990s...
  39. ncbi The toxicology of climate change: environmental contaminants in a warming world
    Pamela D Noyes
    Integrated Toxicology and Environmental Health Program, Duke University, Durham, NC, USA
    Environ Int 35:971-86. 2009
    ..Moreover, it will be important to predict tipping points that might trigger or accelerate synergistic interactions between climate change and contaminant exposures...
  40. pmc Lead exposure and cardiovascular disease--a systematic review
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 115:472-82. 2007
    ..This systematic review evaluates the evidence on the association between lead exposure and cardiovascular end points in human populations...
  41. ncbi Public health importance of triggers of myocardial infarction: a comparative risk assessment
    Tim S Nawrot
    Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
    Lancet 377:732-40. 2011
    ..However, the importance and relevance of each trigger are uncertain. We compared triggers of myocardial infarction at an individual and population level...
  42. ncbi The relationship between diabetes mellitus and traffic-related air pollution
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    J Occup Environ Med 50:32-8. 2008
    ..Many of the biological pathways involved could also promote diabetes mellitus (DM). We therefore investigated the association between DM prevalence and exposure to traffic-related air pollution (nitrogen dioxide [NO 2])...
  43. ncbi What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?
    Matthias Wormuth
    Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland
    Risk Anal 26:803-24. 2006
    ..The scenario-based approach chosen in the present study provides a link between the knowledge on emission sources of phthalates and the concentrations of phthalate metabolites found in human urine...
  44. pmc Exposure assessment for estimation of the global burden of disease attributable to outdoor air pollution
    Michael Brauer
    School of Population and Public Health, The University of British Columbia, 2206 East Mall, Vancouver, British Columbia V6T1Z3, Canada
    Environ Sci Technol 46:652-60. 2012
    ..Combined with spatially resolved population distributions, these estimates expand the evaluation of the global health burden associated with outdoor air pollution...
  45. pmc Cause-specific mortality and the extended effects of particulate pollution and temperature exposure
    Patrick G Goodman
    School of Physics, Dublin Institute of Technology, and St James Hospital, Dublin, Ireland
    Environ Health Perspect 112:179-85. 2004
    ..This analysis suggests that studies on the acute effects of air pollution have underestimated the total effects of temperature and particulate air pollution on mortality...
  46. ncbi Changes in DNA methylation patterns in subjects exposed to low-dose benzene
    Valentina Bollati
    Molecular Epidemiology Laboratory, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, 20122 Milan, Italy
    Cancer Res 67:876-80. 2007
    ..20). This is the first human study to link altered DNA methylation, reproducing the aberrant epigenetic patterns found in malignant cells, to low-level carcinogen exposure...
  47. ncbi Phthalates: toxicology and exposure
    Ursel Heudorf
    Public Health Department of the City of Frankfurt, Germany
    Int J Hyg Environ Health 210:623-34. 2007
    ..However, health concern is raised regarding the developmental and/or reproductive toxicity of phthalates, even in environmental concentrations...
  48. ncbi Blood, urine, and sweat (BUS) study: monitoring and elimination of bioaccumulated toxic elements
    Stephen J Genuis
    University of Alberta, Edmonton, AB, Canada
    Arch Environ Contam Toxicol 61:344-57. 2011
    ..Sweat analysis should be considered as an additional method for monitoring bioaccumulation of toxic elements in humans...
  49. ncbi Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States
    Environ Sci Technol 45:8037-45. 2011
    ..Nonetheless, these NHANES data suggest that sociodemographic factors may influence exposure and also provide unique information on temporal trends of exposure...
  50. pmc Bisphenol A data in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both
    Richard W Stahlhut
    Environmental Health Sciences Center, University of Rochester Medical Center, Rochester, New York 14642, USA rochester edu
    Environ Health Perspect 117:784-9. 2009
    ..If this is correct, BPA levels in fasting individuals should decrease with increased fasting time...
  51. ncbi Environmental exposure to cadmium and risk of cancer: a prospective population-based study
    Tim Nawrot
    Study Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
    Lancet Oncol 7:119-26. 2006
    ..We aimed to assess the association between environmental exposure to cadmium and cancer.
  52. pmc Tubular and glomerular kidney effects in Swedish women with low environmental cadmium exposure
    Agneta Akesson
    Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 113:1627-31. 2005
    ..Although the effects were small, they may represent early signs of adverse effects, affecting large segments of the population. Subjects with diabetes seem to be at increased risk...
  53. ncbi Arsenic exposure and prevalence of type 2 diabetes in US adults
    Ana Navas-Acien
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room W7033B, Baltimore, MD 21205, USA
    JAMA 300:814-22. 2008
    ..In contrast, arsenobetaine, an organic arsenic compound derived from seafood intake, is considered nontoxic...
  54. pmc Protecting human health from air pollution: shifting from a single-pollutant to a multipollutant approach
    Francesca Dominici
    Department of Biostatistics, Harvard University School of Public Health, Boston, MA 02115, USA
    Epidemiology 21:187-94. 2010
    ..Although there is general agreement that multipollutant approaches are desirable, the challenges of implementing them are vast...
  55. ncbi Traffic-related air pollution and childhood respiratory symptoms, function and allergies
    Emma Nordling
    Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
    Epidemiology 19:401-8. 2008
    ..Urban air pollution can trigger asthma symptoms in children, but there is conflicting evidence on effects of long-term exposure on lung function, onset of airway disease and allergic sensitization...
  56. pmc Prenatal exposure to PBDEs and neurodevelopment
    Julie B Herbstman
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, Columbia Center for Children s Environmental Health, New York, New York 10032, USA
    Environ Health Perspect 118:712-9. 2010
    ..Animal studies suggest that prenatal PBDE exposure may result in adverse neurodevelopmental effects...
  57. pmc Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collections
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 119:983-8. 2011
    ..Therefore, there is considerable within-person and between-person variability of BPA concentrations in spot urine samples. However, no information exists on the within-day variability of urinary BPA concentrations...
  58. pmc Low dose organochlorine pesticides and polychlorinated biphenyls predict obesity, dyslipidemia, and insulin resistance among people free of diabetes
    Duk Hee Lee
    Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, Korea
    PLoS ONE 6:e15977. 2011
    ..The current study examined if low dose POPs predicted future adiposity, dyslipidemia, and insulin resistance among controls without diabetes in that study...
  59. pmc Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks
    Allan Peter Davis
    Department of Bioinformatics, The Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA
    Nucleic Acids Res 37:D786-92. 2009
    ..This wealth of chemical-gene-disease information yields testable hypotheses for understanding the effects of environmental chemicals on human health. CTD is freely available at http://ctd.mdibl.org...
  60. ncbi A longitudinal, population-based, cohort study of childhood asthma followed to adulthood
    Malcolm R Sears
    Firestone Institute for Respiratory Health, Department of Medicine, McMaster University and St Joseph s Healthcare, Hamilton, Ont, Canada
    N Engl J Med 349:1414-22. 2003
    ..The outcome of childhood asthma in adults has been described in high-risk cohorts, but few population-based studies have reported the risk factors for persistence and relapse...
  61. pmc Environmental estrogens and obesity
    Retha R Newbold
    Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States
    Mol Cell Endocrinol 304:84-9. 2009
    ....
  62. pmc Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males
    Richard W Stahlhut
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Environ Health Perspect 115:876-82. 2007
    ..Low testosterone in adult human males has been associated with increased prevalence of obesity, insulin resistance, and diabetes...
  63. ncbi Arsenic exposure during pregnancy and size at birth: a prospective cohort study in Bangladesh
    Anisur Rahman
    International Centre for Diarrhoeal Disease Research, Bangladesh, Mohakhali, Dhaka, Bangladesh
    Am J Epidemiol 169:304-12. 2009
    ..14 (SE, 0.03) mm per 1 microg/L, respectively. No further negative effects were shown at higher levels of arsenic exposure. The indicated negative effect on birth size at a low level of arsenic exposure warrants further investigation...
  64. ncbi Temperature extremes and health: impacts of climate variability and change in the United States
    Marie S O'Neill
    Department of Epidemiology and Environmental Health Dr Neill, University of Michigan School of Public Health, Ann Arbor, Mich, USA
    J Occup Environ Med 51:13-25. 2009
    ..We evaluated temperature-related morbidity and mortality for the 2007 U.S. national assessment on impacts of climate change and variability on human health...
  65. pmc Hypertension and exposure to noise near airports: the HYENA study
    Lars Jarup
    Department of Epidemiology and Public Health, Imperial College London, St Mary s Campus, Norfolk Place, London, United Kingdom
    Environ Health Perspect 116:329-33. 2008
    ..Hypertension is an important risk factor for cardiovascular disease, and even a small contribution in risk from environmental factors may have a major impact on public health...
  66. pmc Manganese and Parkinson's disease: a critical review and new findings
    Tomas R Guilarte
    Neurotoxicology and Molecular Imaging Laboratory, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 118:1071-80. 2010
    ..Recently, scientists have debated the possibility that Mn may have an etiological role in PD or that it may accelerate the expression of PD...
  67. pmc Outbreak of fatal childhood lead poisoning related to artisanal gold mining in northwestern Nigeria, 2010
    Carrie A Dooyema
    Healthy Homes and Lead Poisoning Prevention Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 120:601-7. 2012
    ..In May 2010, a team of national and international organizations was assembled to investigate children's deaths due to lead poisoning in villages in northwestern Nigeria...
  68. ncbi Estimating the health effects of exposure to multi-pollutant mixture
    Cécile Billionnet
    Ann Epidemiol 22:126-41. 2012
    ....
  69. pmc Endocrine disruptors and asthma-associated chemicals in consumer products
    Robin E Dodson
    Silent Spring Institute, Newton, Massachusetts 02458, USA
    Environ Health Perspect 120:935-43. 2012
    ..Laboratory and human studies raise concerns about endocrine disruption and asthma resulting from exposure to chemicals in consumer products. Limited labeling or testing information is available to evaluate products as exposure sources...
  70. ncbi Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity
    Jerrold J Heindel
    Division of Extramural Research and Training, National Institute of Environmental Health Sciences, NIH DHHS, Cellular, Organs and Systems Pathobiology Branch, Research Triangle Park, NC 27709, USA
    Mol Cell Endocrinol 304:90-6. 2009
    ..Eliminating exposures to these chemicals and improving nutrition during development offer the potential for reducing obesity and associated diseases...
  71. pmc Prospective study of particulate air pollution exposures, subclinical atherosclerosis, and clinical cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air)
    Joel D Kaufman
    Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, USA
    Am J Epidemiol 176:825-37. 2012
    ..The overarching study aim is to understand and reduce uncertainty in health effect estimation regarding long-term exposure to air pollution and CVD...
  72. ncbi Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States
    S L Teitelbaum
    Mount Sinai School of Medicine, Department of Community and Preventive Medicine, 1 Gustave Levy Place, P O Box 1043, New York, NY 10029, USA
    Environ Res 106:257-69. 2008
    ..However, reliability in the use of these biomarkers requires an understanding of the timeframe of exposure represented by one measurement. Data on the temporal variability of ED biomarkers are sparse, especially among children...
  73. pmc Developmental origins of non-communicable disease: implications for research and public health
    Robert Barouki
    INSERM UMR S, Universite Paris Descartes, France
    Environ Health 11:42. 2012
    ....
  74. pmc Maternal cadmium exposure during pregnancy and size at birth: a prospective cohort study
    Maria Kippler
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 120:284-9. 2012
    ..Cadmium (Cd) is an embryotoxic and teratogenic metal in a variety of animal species, but data from humans are limited...
  75. pmc Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico
    Luz M Del Razo
    Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Mexico DF, Mexico
    Environ Health 10:73. 2011
    ..Our study examined associations between chronic exposure to iAs in drinking water, metabolism of iAs, and prevalence of diabetes in arsenicosis-endemic areas of Mexico...
  76. pmc Rice consumption contributes to arsenic exposure in US women
    Diane Gilbert-Diamond
    Children s Environmental Health and Disease Prevention Center at Dartmouth, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 108:20656-60. 2011
    ..Our findings along with others indicate that rice consumption should be considered when designing arsenic reduction strategies in the United States...
  77. pmc Fine particulate air pollution and its components in association with cause-specific emergency admissions
    Antonella Zanobetti
    Department of Environmental Health, School of Public Health, Harvard University, Boston, MA, USA
    Environ Health 8:58. 2009
    ..We explored whether the association between cause-specific hospital admissions and PM(2.5) was modified by PM(2.5) chemical composition...
  78. ncbi Prenatal ambient air exposure to polycyclic aromatic hydrocarbons and the occurrence of respiratory symptoms over the first year of life
    Wieslaw Jedrychowski
    Epidemiology and Preventive Medicine, Jagiellonian University Medical College, 7 Kopernika Street, Krakow, Poland
    Eur J Epidemiol 20:775-82. 2005
    ....
  79. ncbi Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs
    LILIAN CALDERON-GARCIDUENAS
    Instituto Nacional de Pediatria, Mexico City, Mexico
    Brain Cogn 68:117-27. 2008
    ..The present work presents a groundbreaking, interdisciplinary methodology for addressing relationships between environmental pollution, structural brain alterations by MRI, and cognitive deficits/delays in healthy children...
  80. ncbi Blood mercury levels in US children and women of childbearing age, 1999-2000
    Susan E Schober
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 289:1667-74. 2003
    ..The fetus is most sensitive to the adverse effects of exposure. The extent of exposure to methylmercury in US women of reproductive age is not known...
  81. pmc Residential proximity to freeways and autism in the CHARGE study
    Heather E Volk
    Department of Preventive Medicine, Zilkha Neurogenetic Institute, Keck School of Medicine, Children s Hospital Los Angeles, University of Southern California, Los Angeles, California 90033, USA
    Environ Health Perspect 119:873-7. 2011
    ..Traffic-related air pollution, a common exposure with established effects on these pathways, contains substances found to have adverse prenatal effects...
  82. ncbi Chronic systemic pesticide exposure reproduces features of Parkinson's disease
    R Betarbet
    Department of Neurology, Emory University, 1639 Pierce Drive, WMB 6000, Atlanta, Georgia 30322, USA
    Nat Neurosci 3:1301-6. 2000
    ..These results indicate that chronic exposure to a common pesticide can reproduce the anatomical, neurochemical, behavioral and neuropathological features of PD...
  83. pmc Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth
    Carrie V Breton
    Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 183:243-8. 2011
    ..Glutathione plays an important role in antioxidant and inflammatory processes in the lung. Alterations in glutathione metabolism are a central feature of several chronic lung diseases...
  84. ncbi Acute myocardial infarction mortality in comparison with lung and bladder cancer mortality in arsenic-exposed region II of Chile from 1950 to 2000
    Yan Yuan
    Arsenic Health Effects Research Program, University of California, Berkeley, CA 94720 7360, USA
    Am J Epidemiol 166:1381-91. 2007
    ..With these three causes of death combined, increased mortality peaked in 1991-1995, with estimated excess deaths related to arsenic exposure constituting 10.9% of all deaths among men and 4.0% among women...
  85. pmc Epigenetics and environmental chemicals
    Andrea Baccarelli
    Laboratory of Environmental Epigenetics, Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, Milan, Italy
    Curr Opin Pediatr 21:243-51. 2009
    ..Here, we review current evidence indicating that epigenetic alterations mediate toxicity from environmental chemicals...
  86. pmc Organochlorine exposure and incidence of diabetes in a cohort of Great Lakes sport fish consumers
    Mary Turyk
    Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, Illinois 60612, USA
    Environ Health Perspect 117:1076-82. 2009
    ..Prospective studies, however, have been lacking...
  87. ncbi Reproductive toxicity of phthalate esters
    Anderson Joel Martino-Andrade
    Universidade Federal do Parana, Departamento de Fisiologia, Curitiba, Brazil
    Mol Nutr Food Res 54:148-57. 2010
    ..Finally, we point out some critical issues that should be addressed in order to clarify the implications of phthalates for human reproduction...
  88. ncbi Obesity and persistent organic pollutants: possible obesogenic effect of organochlorine pesticides and polychlorinated biphenyls
    Eveline Dirinck
    Department of Endocrinology, Diabetology and Clinical Pharmacology, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium
    Obesity (Silver Spring) 19:709-14. 2011
    ..Combined, these results suggest that the diabetogenic effect of low-dose exposure to POPs might be more complicated than a simple obesogenic effect...
  89. ncbi What causes autism? Exploring the environmental contribution
    Philip J Landrigan
    Department of Community and Preventive Medicine, Department of Pediatrics, Children s Environmental Health Center, Mount Sinai School of Medicine, New York, USA
    Curr Opin Pediatr 22:219-25. 2010
    ..However, they account for only a small fraction of cases, and do not easily explain key clinical and epidemiological features. This suggests that early environmental exposures also contribute. This review explores this hypothesis...
  90. pmc Increased risk of diabetes and polychlorinated biphenyls and dioxins: a 24-year follow-up study of the Yucheng cohort
    Shu Li Wang
    Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan
    Diabetes Care 31:1574-9. 2008
    ..We aimed to examine the association between previous high exposures to PCBs and PCDFs and the cumulative incidence of type 2 diabetes and hypertension...
  91. pmc The 'hygiene hypothesis' for autoimmune and allergic diseases: an update
    H Okada
    INSERM U1013, Necker Enfants Malades Hospital, Paris, France
    Clin Exp Immunol 160:1-9. 2010
    ..Taken together, these data open new therapeutic perspectives in the prevention of autoimmune and allergic diseases...
  92. pmc Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans
    Shanna H Swan
    Department of Obstetrics and Gynecology, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 668, Rochester, NY 14642, USA
    Environ Res 108:177-84. 2008
    ..This is one of an increasing number of studies that have investigated human endpoints in relation to environmental exposure to these ubiquitous compounds...
  93. pmc Variability over 1 week in the urinary concentrations of metabolites of diethyl phthalate and di(2-ethylhexyl) phthalate among eight adults: an observational study
    James L Preau
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 118:1748-54. 2010
    ..Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months...
  94. pmc Endocrine disrupters as obesogens
    Felix Grün
    Department of Developmental and Cell Biology, University of California Irvine, 92697 2300, USA
    Mol Cell Endocrinol 304:19-29. 2009
    ..This review highlights recent advances in our understanding of the molecular targets and mechanisms of action for these compounds and areas of future research needed to evaluate the significance of their contribution to obesity...
  95. ncbi Monitoring and reducing exposure of infants to pollutants in house dust
    John W Roberts
    US Environmental Protection Agency, Reston, VA 22091, USA
    Rev Environ Contam Toxicol 201:1-39. 2009
    ..We believe that proven intervention methods can reduce the exposure of infants to pollutants in house dust, while recognizing that much remains to be learned about improving the effectiveness of such methods...
  96. ncbi Relation between elevated ambient temperature and mortality: a review of the epidemiologic evidence
    Rupa Basu
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Epidemiol Rev 24:190-202. 2002
  97. pmc Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population
    Brenda Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California Berkeley, 94720 7380, USA
    Environ Health Perspect 112:1116-24. 2004
    ..However, despite these observed associations, the rate of preterm delivery in this population (6.4%) was lower than in a U.S. reference population...
  98. pmc Childhood incident asthma and traffic-related air pollution at home and school
    Rob McConnell
    University of Southern California, Los Angeles, California, USA
    Environ Health Perspect 118:1021-6. 2010
    ..Traffic-related air pollution has been associated with adverse cardiorespiratory effects, including increased asthma prevalence. However, there has been little study of effects of traffic exposure at school on new-onset asthma...
  99. pmc Persistent exposure to arsenic via drinking water in rural Bangladesh despite major mitigation efforts
    Renee Gardner
    Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
    Am J Public Health 101:S333-8. 2011
    ..We evaluated the effectiveness of long-term mitigation efforts by longitudinally measuring arsenic exposure in pregnant women and their children, the most susceptible population groups...
  100. pmc Ecological risk assessment in the context of global climate change
    Wayne G Landis
    Western Washington University, Institute of Environmental Toxicology, Bellingham, WA, USA
    Environ Toxicol Chem 32:79-92. 2013
    ..Good communication is essential for making risk-related information understandable and useful for managers and stakeholders to implement a successful risk-assessment and decision-making process...
  101. ncbi Epigenetic gene regulation: linking early developmental environment to adult disease
    Dana C Dolinoy
    Department of Radiation Oncology, Duke University Medical Center, Box 3433, Durham, NC 27710, United States
    Reprod Toxicol 23:297-307. 2007
    ....

Research Grants73

  1. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2011
    ..NTP) hazard assessment activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents...
  2. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2012
    ..NTP) hazard assessment activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents...
  3. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..propose to conduct a series of nested case-control studies within the two cohorts to elucidate the role of environmental exposure, genetic variants and DNA methylation in the development of lung or liver cancer...
  4. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..The proposed study will address these knowledge gaps by measuring environmental exposure to air pollution mixtures and resulting acute health outcomes and biomarkers in adolescents...
  5. SUPPORT CONTRACT FOR THE NTP INTERAGENCY CENTER/VALIDATION OF ALT METHODS
    David Allen; Fiscal Year: 2009
    ..NTP) hazard assessment activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents...
  6. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..their objective and mission that "human health and human disease result from three interactive elements: environmental exposure, genetic susceptibility, and age...
  7. MOLECULAR MECHANISMS OF COMPLEX MIXTURE TOXICITY
    Alvaro Puga; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Environmental exposure to hexavalent chromium in drinking water and cigarette smoking and occupational exposure in the workplace ..
  8. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010
    ..addresses broad Challenge Area, (08) Genomics and Specific Challenge Topic, 08-ES-106: The role of environmental exposure in copy number variation (CNV): "Microscopic deletions and replications of the genome have attracted ..
  9. Roles of NF-kB/Rel in the pathogenesis of breast cancer
    Gail E Sonenshein; Fiscal Year: 2012
    ..In an attempt to find the reasons, environmental exposure and dietary factors are being studied...
  10. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2012
    ..The intensity of environmental exposure required to cause disease is likely inversely related to the degree of genetic vulnerability: the greater ..
  11. Proteomic signatures of an early life asthma-protective exposure
    Serrine S Lau; Fiscal Year: 2010
    ..establish robust correlations between the biomarkers identified through the proposed experimental plan and environmental exposure and/or the disease outcome of asthma...
  12. Oxidative stress and neurogenetic networks in Drosophila
    Robert R H Anholt; Fiscal Year: 2010
    ..quantify in genetically heterogeneous human populations, where it is also virtually impossible to control environmental exposure. Drosophila melanogaster provides a genetically tractable model system, because the genetic background and ..
  13. Detection of engineered nanomaterials in drinking water, food, commercial product
    Paul K Westerhoff; Fiscal Year: 2010
    ..detection limits with toxic threshold information to evaluate the prospects of using these novel tools for environmental exposure assessment and for protecting human health...
  14. Preconception Nutrition, Endocrine Disruptors, Reproductive Outcomes
    Xiaobin Wang; Fiscal Year: 2013
    ..test the hypotheses that preconception BMI and micronutrient status can modify the relationships between environmental exposure to DDT/DDE and reproductive outcomes...
  15. Environmental Chitin Exposure in the Pathogenesis of Asthma
    Rene M Roy; Fiscal Year: 2012
    ..These facts raise the possibility that environmental exposure to chitin is a key factor in the pathogenesis of asthma...
  16. Lung Toxicity of Carbon Nanotubes in Models of Pre-Existing Respiratory Disease
    JAMES CHRISTOPHER BONNER; Fiscal Year: 2010
    ..Human and environmental exposure to carbon nanotubes is inevitably increasing due to increased production for a variety of uses in ..
  17. NAPS2 Continuation Genome Wide Association Study of Pancreatitis
    DAVID CLEMENT WHITCOMB; Fiscal Year: 2011
    ..across all NAPS2 sites to collect phenotypic data from medical history, family history, and quantitative environmental exposure measures...
  18. Mesothelioma inhibition by secoisolariciresinol diglucoside (SDG)
    Melpo Christofidou-Solomidou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite worldwide banning of asbestos use, domestic and environmental exposure to asbestos unfortunately persists...
  19. Free Radical Mechanism in Obesity Potentiation of Environmental Hepatotoxicity
    Saurabh Chatterjee; Fiscal Year: 2013
    ..This second hit can be provided by environmental exposure to hepatotoxins that are reductively metaboiized to form reactive free radicals...
  20. DNA METHYLOME STUDY IN TYPE 1 DIABETES
    ART PETRONIS; Fiscal Year: 2009
    ..one twin is affected and his/her co-twin stays healthy despite their identical DNA sequences and similar environmental exposure. Differences in the incidence of T1D between males and females could also be of epigenetic origin...
  21. Environmental and genetic regulation of copy number variation (CNV)
    THOMAS PETES; Fiscal Year: 2010
    ..the broad Challenge Area (08), "Genomics", and the specific Challenge Topic (08-ES-106), "The role of environmental exposure in copy number variation (CNV)"...
  22. PHAHs and Thyroid Cancer Risk in DoDSR Cohort
    Yawei Zhang; Fiscal Year: 2013
    ..3) whether the risk of papillary thyroid cancer and thyroid hormone disruption associated with environmental exposure to PHAHs varies by genetic polymorphisms in major genes coding for enzymes involved in the regulation, ..
  23. Prenatal Bisphenol A and Sexually Dimorphic Neurodevelopment
    Bernard Weiss; Fiscal Year: 2010
    ..question seen by both the public and by scientific review panels as crucial to weighing the risks posed by environmental exposure to BPA...
  24. CHILDHOOD DIOXIN EXPOSURE AND ENERGY HOMEOSTASIS DYSREGULATION
    Jane S Burns; Fiscal Year: 2010
    ..physical activity are well-known risk factors for obesity and diabetes, there is increasing evidence that environmental exposure to chemicals may also play a role...
  25. Dual role of the bradykinin B2 receptor during inflammation
    Bruce L Zuraw; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): 6. Project Summary/Abstract Environmental exposure to viruses, noxious stimuli and allergens leads to the rapid generation of kinins in the airway...
  26. Absorption, distribution, metabolism, excretion (ADME) of chemicals in mammals
    Rochelle W Tyl; Fiscal Year: 2009
    ..DCP is a semi-volatile liquid that is used in high volume as an intermediate in chemical synthesis. Environmental exposure to DCP can come from ingestion of food to which hydrochloric acid catalyzed vegetable protein has been ..
  27. P53-dependent responses to toxicants in parous and nulliparous breast
    D Joseph Jerry; Fiscal Year: 2010
    ..Three classes of environmental exposure, each with a strong epidemiologic and toxicological literature, have been selected for study: IR, PAHs, ..
  28. Gut flora metabolism of dietary phosphatidylcholine and cardiovascular disease
    Stanley L Hazen; Fiscal Year: 2013
    ..comprised of trillions of typically non-pathogenic commensal organisms, serve as a filter for our greatest environmental exposure - what we eat. Gut flora play an essential role, aiding in the digestion and absorption of many nutrients...
  29. Role of the Indoor Environment on Oxidative Stress Related Sinonasal Inflammation
    Murugappan Ramanathan; Fiscal Year: 2013
    ..Ramanathan seeks to better understand the impact of indoor environmental exposure (particulate matter and allergens) on oxidative stress based sinonasal inflammation regulated by the Nrf2 ..
  30. Shared Mechanisms of Pulmonary Lymphocyte Activation by Bacteria and Toxicants
    Michael Borchers; Fiscal Year: 2010
    b>Environmental exposure to fundamentally diverse agonists such as bacteria and air pollutants can signal through shared mechanisms to activate the innate immune system...
  31. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2009
    ..or hazard assessment) activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents...
  32. Environmental exposure: Susceptibility alleles in a DNA damage response pathway
    Peter J Stambrook; Fiscal Year: 2013
    ..The human studies will utilize two unique cohorts with prior environmental exposure in the form of radiation who subsequently developed breast cancer...
  33. Detoxification of Biogeneic Aldehydes in Parkinson's Disease
    Randy Strong; Fiscal Year: 2013
    ..Human and animal studies have established a link between environmental exposure to paraquat, maneb and rotenone in idiopathic or sporadic PD...
  34. Energetics &Breast Cancer: Obesity, Inflammation, Insulin Resistance &Risk
    Ruth E Patterson; Fiscal Year: 2013
    ..existing Geographic Information Systems data for San Diego County, will allow us to develop obesogenic environmental exposure estimates and relate these to metabolic risk factors. Dr...
  35. Early-life bisphenol A, immune dysregulation, and inner-city pediatric asthma
    ROBIN MARJORIE WHYATT; Fiscal Year: 2010
    ..Further, this team can explore novel hypotheses regarding links with environmental exposure to BPA, specific immune dysregulation that includes effects on T regulatory cell function and antigen ..
  36. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2011
    ..or hazard assessment) activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents...
  37. Household air pollution in Tanzania, placental health and pregnancy outcome
    BLAIR JOHNSON WYLIE; Fiscal Year: 2013
    ..The candidate's proposed research has the potential to focus obstetric attention on a prevalent environmental exposure, household air pollution, and to shift environmental interventions to prenatal care packages...
  38. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2010
    ..or hazard assessment) activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents...
  39. Synthetic nanoparticle vaccines for RSV
    THOMAS J POWELL; Fiscal Year: 2012
    ..attempts to develop a formalin- inactivated vaccine (FI-RSV) resulted in disease enhancement following environmental exposure to RSV...
  40. Transgenerational exposures as modifiers of host defense against infection
    B Paige Lawrence; Fiscal Year: 2013
    ..inheritance of alterations in the function of the mammalian immune system that occur as a result of environmental exposure. The immune system is fundamentally important to public and individual health, and even slight ..
  41. Family History, Genes, Environment and G X E Interaction in Predicting RA Risk
    Elizabeth W Karlson; Fiscal Year: 2013
    ..a new collection of RA cases and controls from Partners HealthCare;2a) Collect family history data and environmental exposure data concerning smoking and reproductive factors on 1,500 RA patients and 4,500 age- and gender-matched ..
  42. Epigenetic Modulation of PTPG by Zeranol in Beef Increases Breast Cancer Risk
    Young C Lin; Fiscal Year: 2010
    ..is our intent to provide comprehensive data (exposure levels during Z-implantation and after Z withdrawal from the beef heifers) to raise awareness of environmental exposure to the estrogen mimic, beef growth promoter, Z.
  43. Influence of HFE on metal pharmacokinetics and neurotoxicity
    Jonghan Kim; Fiscal Year: 2013
    ..the relationship between pharmacokinetics of metal absorption and metal-induced toxicity in the context of environmental exposure and genetic susceptibility (gene-environment interactions)...
  44. The Halifax Project: Chemical Mixtures and Cancer
    DAVID ORLO CARPENTER; Fiscal Year: 2013
    ..increasing evidence that most cancers are not due solely to genetics, but are rather a consequence of some environmental exposure. This is not to say that genetics are unimportant, because individuals vary in their susceptibility to ..
  45. Wearable Technology for Assessment of Personal Exposure to Volatile Organic Compo
    Stephen L Coy; Fiscal Year: 2011
    ..goal is to provide a noninvasive, low-profile, near real-time (within 15 seconds), affordable personal environmental exposure monitor platform for monitoring VOC's...
  46. Genetics and the Environment Associated with Male Reproduction (GEAR)
    Sheela Sathyanarayana; Fiscal Year: 2012
    ..among the first studies to examine gene/phthalate interactions in male reproductive development, and 3) contribute to future research that uses genotype, environmental exposure, and phenotype to predict future male reproductive health.
  47. Methods for modeling air pollution effects on exhaled biomarkers
    SANDRAH PROCTOR ECKEL; Fiscal Year: 2013
    ..on developing and applying statistical methods to gain an integrated understanding of the mechanisms of environmental exposure effects...
  48. Role of Prion Protein in Manganese Neurotoxicity
    ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Environmental exposure to transition metals is linked to pathological processes of various neurodegenerative conditions since metal neurotoxicity often augments key degenerative changes including ..
  49. (PQA4) GPS exposure to environments &relations with biomarkers of cancer risk
    Jacqueline Kerr; Fiscal Year: 2013
    ..We hypothesize that dynamic GPS based measures of environmental exposure will be more strongly related to behavior and insulin and inflammation biomarkers than static addressed ..
  50. Environmental exposure to metal mixtures and kidney disease
    Mary Fox; Fiscal Year: 2009
    ..The National Institute for Environmental Health Sciences stated in its 2006-2011 Strategic Plan that maximal public health impact depends on conducting research relevant to societal decision making. ..
  51. CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENAL TOXICOLOGY PROGRAM
    Reshan Fernando; Fiscal Year: 2010
    ..hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents...
  52. PATHOLOGY SUPPORT FOR THE NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
    TODD PAINTER; Fiscal Year: 2009
    ..hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents...
  53. Environmental Epigenetics and Stem/Progenitor Cell Injury
    Tim H M Huang; Fiscal Year: 2010
    b>Environmental exposure to endocrine-disrupting agents, or xenoestrogens, can increase the risk of developing breast cancer...
  54. Advanced glycation end products and colorectal cancer risk in women
    Li Jiao; Fiscal Year: 2012
    ..The long- term goal of this research is to elucidate a modifiable pathway, AGEs/RAGE, that may connect environmental exposure (e.g., dietary intake), inflammation, and insulin resistance with CRC etiology and prognosis...
  55. PATHOLOGY SUPPORT FOR THE NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
    James Morrison; Fiscal Year: 2011
    ..hazard identification activities targeted toward the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents...
  56. Process for Removal of Microcontaminants from Municipal Water
    JAMES H WHITE; Fiscal Year: 2010
    ..A study by Thurman et al.,1 revealed that subtle, chronic effects from low- level environmental exposure to select organic wastewater contaminants may be of concern...
  57. Diet-Environment Interactions in Inflammation
    Sanjay Rajagopalan; Fiscal Year: 2013
    ..The insights gleaned from these studies have significant public health ramifications and may eventually lead to appropriately designed human studies eventually culminating in policy changes to avert environmental exposure to PM2.5.
  58. Mechanisms of Manganese Neurotoxicity
    ANUMANTHA GOUNDER KANTHASAMY; Fiscal Year: 2013
    ..We anticipate that the proposed study will provide comprehensive information about how environmental exposure to manganese can alter the expression of the key proapoptotic gene PKCd to augment manganese neurotoxicity,..
  59. MEASUREMENT ERRORS IN ENVIRONMENTAL EPIDEMIOLOGY
    DONNA L SPIEGELMAN; Fiscal Year: 2013
    ..We featured these new methods in a number of publications on the health effects of environmental exposure to endotoxin, methyl tert-butyl ether, lead, and indoor NO2, and developed publicly available software...
  60. Effects of Long-Term Low Level Hydrogen Sulfide Exposure
    Michael N Bates; Fiscal Year: 2010
    ..Study results will either confirm the adequacy of current U.S. occupational and environmental exposure standards for H2S or provide evidence that they are insufficiently health protective.
  61. Exploring Interactions between Folate and Environmental Risk Factors for Autism
    REBECCA JEAN SCHMIDT; Fiscal Year: 2013
    ..of global DNA methylation as a mechanism by which folate status may modify susceptibility to the environmental exposure effects will be tested...
  62. Susceptible Window of High Fat Diet/Bisphenol A Programming of Breast Cancer Risk
    Shuk Mei Ho; Fiscal Year: 2013
    ..predisposition accounts for less than 15% of BCa risk while main etiological factors are those related to environmental exposure and lifestyle choices...
  63. Effect of chronic low-dose phthalate exposure on the immature primate testis
    Ina Dobrinski; Fiscal Year: 2009
    ..b>Environmental exposure to reproductive toxicants is of serious concern to human health and has been implicated in both the ..
  64. SUPERFUND TOXIC SUBSTANCES--EXPOSURE AND DISEASE
    Karl Kelsey; Fiscal Year: 2006
    ..Reproductive health is being evaluated in relation to environmental exposure to lead, mercury, polychlorinated biphenyls (PCBs) and related compounds; cardio-respiratory health is ..
  65. ORGANOCHLORINE COMPOUNDS AND RISK OF BREAST CANCER
    Tongzhang Zheng; Fiscal Year: 1993
    ..Recent epidemiologic studies strongly suggest that environmental exposure to organochlorine residues increases the risk of female breast cancer...
  66. HAIR DYE USE AND RISK OF NONHODGKINS LYMPHOMA
    Tongzhang Zheng; Fiscal Year: 2000
    ..It has been suggested that the environmental exposure which seems most likely to have contributed to the increase in NHL among women is that of hair dyes...
  67. OCCUPATIONAL ASTHMA ASOCIATED WITH SEAFOOD PROCESSING
    Thomas Robins; Fiscal Year: 2001
    ..A cross-sectional study is proposed to characterize the occupational environmental exposure of workers in a factory on the West Coast of South Africa, involved in the processing of rock lobster and ..
  68. Novel Chelators for Highly Efficient Removal of Toxic Heavy Metals in Humans
    Charles Timchalk; Fiscal Year: 2009
    ..lead to a breakthrough in the field of chelation chemistry, specifically for heavy metals in humans after environmental exposure. This work addresses a key mission of NIEHS since the institute "has primary responsibility with respect ..
  69. Health Effects of CREON2000 In Asthmatic Children
    Mark Glazman; Fiscal Year: 2003
    ..A unique system of prolonged environmental exposure assessment which correlates clinical symptoms, objective changes in lung function and allergen ..
  70. Morbidity and Mortality in Marysville, Ohio due to Exposure to Asbestos Contamina
    James Lockey; Fiscal Year: 2010
    ..and Mortality in Marysville, Ohio due to Exposure to Asbestos Contaminated Vermiculite Occupational and environmental exposure to vermiculite mined in Libby, Montana is associated with increased pulmonary morbidity and mortality...
  71. RADON, BRONCHIAL MORPHOMETRY, AND OCCUPATIONAL HEALTH
    David Brenner; Fiscal Year: 1993
    The hazards of occupational exposure to radon daughters relative to environmental exposure is significant both for occupational and environmental health...
  72. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..Thus, given environmental exposure, susceptibility to carcinogens is determined, in part, by the competence of enzymatic detoxification...
  73. Preventing Child Residential Lead Exposure By Window Replacement
    MICHAEL LANE WEITZMAN; Fiscal Year: 2010
    ..Exposure By Window Replacement Childhood lead poisoning remains the most ubiquitous and pernicious child environmental exposure and disproportionately affects impoverished, minority children living in pre-1950s housing...