vehicle emissions

Summary

Summary: Gases, fumes, vapors, and odors escaping from the cylinders of a gasoline or diesel internal-combustion engine. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Random House Unabridged Dictionary, 2d ed)

Top Publications

  1. pmc A cohort study of traffic-related air pollution impacts on birth outcomes
    Michael Brauer
    School of Environmental Health, The University of British Columbia, 2206 East Mall, Vancouver BC V6T1Z3 Canada
    Environ Health Perspect 116:680-6. 2008
  2. pmc Comparing exposure assessment methods for traffic-related air pollution in an adverse pregnancy outcome study
    Jun Wu
    Program in Public Health and Department of Epidemiology, Anteater Instruction and Research Office, University of California, Irvine, CA 92697 3957, USA
    Environ Res 111:685-92. 2011
  3. pmc Traffic-related air pollution and cognitive function in a cohort of older men
    Melinda C Power
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 119:682-7. 2011
  4. ncbi Changes in atherosclerotic plaques induced by inhalation of diesel exhaust
    Ni Bai
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    Atherosclerosis 216:299-306. 2011
  5. ncbi The relationship between diabetes mellitus and traffic-related air pollution
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    J Occup Environ Med 50:32-8. 2008
  6. ncbi Traffic-related air pollution and childhood respiratory symptoms, function and allergies
    Emma Nordling
    Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
    Epidemiology 19:401-8. 2008
  7. ncbi Long-term exposure to traffic-related air pollution and lung cancer risk
    Rob Beelen
    Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
    Epidemiology 19:702-10. 2008
  8. pmc Fine particulate air pollution and its components in association with cause-specific emergency admissions
    Antonella Zanobetti
    Department of Environmental Health, School of Public Health, Harvard University, Boston, MA, USA
    Environ Health 8:58. 2009
  9. pmc In-traffic air pollution exposure and CC16, blood coagulation, and inflammation markers in healthy adults
    Moniek Zuurbier
    Public Health Services Gelderland Midden, Arnhem, The Netherlands
    Environ Health Perspect 119:1384-9. 2011
  10. pmc Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction
    Chunli Quan
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Inhal Toxicol 22:738-53. 2010

Detail Information

Publications392 found, 100 shown here

  1. pmc A cohort study of traffic-related air pollution impacts on birth outcomes
    Michael Brauer
    School of Environmental Health, The University of British Columbia, 2206 East Mall, Vancouver BC V6T1Z3 Canada
    Environ Health Perspect 116:680-6. 2008
    ..Evidence suggests that air pollution exposure adversely affects pregnancy outcomes. Few studies have examined individual-level intraurban exposure contrasts...
  2. pmc Comparing exposure assessment methods for traffic-related air pollution in an adverse pregnancy outcome study
    Jun Wu
    Program in Public Health and Department of Epidemiology, Anteater Instruction and Research Office, University of California, Irvine, CA 92697 3957, USA
    Environ Res 111:685-92. 2011
    ..Yet, little information exists on how effect estimates are impacted by the different exposure assessment methods employed in these studies...
  3. pmc Traffic-related air pollution and cognitive function in a cohort of older men
    Melinda C Power
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 119:682-7. 2011
    ..Traffic-related particles induce oxidative stress and may exert adverse effects on central nervous system function, which could manifest as cognitive impairment...
  4. ncbi Changes in atherosclerotic plaques induced by inhalation of diesel exhaust
    Ni Bai
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    Atherosclerosis 216:299-306. 2011
    ..We hypothesize that exposure to diesel exhaust (DE), an important source of traffic-related particulate air pollution, promotes changes of atherosclerotic plaque component that may lead to plaque vulnerability...
  5. ncbi The relationship between diabetes mellitus and traffic-related air pollution
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    J Occup Environ Med 50:32-8. 2008
    ..Many of the biological pathways involved could also promote diabetes mellitus (DM). We therefore investigated the association between DM prevalence and exposure to traffic-related air pollution (nitrogen dioxide [NO 2])...
  6. ncbi Traffic-related air pollution and childhood respiratory symptoms, function and allergies
    Emma Nordling
    Department of Occupational and Environmental Health, Stockholm County Council, Stockholm, Sweden
    Epidemiology 19:401-8. 2008
    ..Urban air pollution can trigger asthma symptoms in children, but there is conflicting evidence on effects of long-term exposure on lung function, onset of airway disease and allergic sensitization...
  7. ncbi Long-term exposure to traffic-related air pollution and lung cancer risk
    Rob Beelen
    Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands
    Epidemiology 19:702-10. 2008
    ..Most studies on the association between lung cancer and air pollution have investigated mortality. There have been few studies of lung cancer incidence...
  8. pmc Fine particulate air pollution and its components in association with cause-specific emergency admissions
    Antonella Zanobetti
    Department of Environmental Health, School of Public Health, Harvard University, Boston, MA, USA
    Environ Health 8:58. 2009
    ..We explored whether the association between cause-specific hospital admissions and PM(2.5) was modified by PM(2.5) chemical composition...
  9. pmc In-traffic air pollution exposure and CC16, blood coagulation, and inflammation markers in healthy adults
    Moniek Zuurbier
    Public Health Services Gelderland Midden, Arnhem, The Netherlands
    Environ Health Perspect 119:1384-9. 2011
    ..Little is known about effects of the short exposures encountered while participating in traffic...
  10. pmc Comparative effects of inhaled diesel exhaust and ambient fine particles on inflammation, atherosclerosis, and vascular dysfunction
    Chunli Quan
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA
    Inhal Toxicol 22:738-53. 2010
    ....
  11. pmc Traffic-related air pollution and incident type 2 diabetes: results from the SALIA cohort study
    Ursula Kramer
    Institut fur umweltmedizinische Forschung IUF, Leibniz Center at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Environ Health Perspect 118:1273-9. 2010
    ..Cross-sectional and ecological studies indicate that air pollution may be a risk factor for type 2 diabetes, but prospective data are lacking...
  12. ncbi Near-roadway air quality: synthesizing the findings from real-world data
    Alex A Karner
    U C Davis Caltrans Air Quality Project, Department of Civil and Environmental Engineering, University of California, Davis, California 95616, USA
    Environ Sci Technol 44:5334-44. 2010
    ..g., benzene, nitrogen dioxide); or no trend with distance (e.g., particulate matter mass concentrations)...
  13. ncbi Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly
    Ulrich Ranft
    Institut für Umweltmedizinische Forschung IUF an der Heinrich Heine Universität Düsseldorf, Dusseldorf, Auf m Hennekamp 50, 40225 Dusseldorf, Germany
    Environ Res 109:1004-11. 2009
    ..The associations were adjusted for potential confounders using regression analysis. These results indicate that chronic exposure to traffic-related PM may be involved in the pathogenesis of AD...
  14. ncbi Air pollution combustion emissions: characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects
    Joellen Lewtas
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195 4695, USA
    Mutat Res 636:95-133. 2007
    ....
  15. pmc Diabetes incidence and long-term exposure to air pollution: a cohort study
    Zorana J Andersen
    1Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Diabetes Care 35:92-8. 2012
    ..We studied the association between long-term exposure to traffic-related air pollution and incidence of diabetes...
  16. pmc Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California 92617, USA
    Environ Health Perspect 117:1232-8. 2009
    ..Experimental evidence suggests that organic components and ultrafine particles (UFP) are important...
  17. ncbi Application of land use regression to estimate long-term concentrations of traffic-related nitrogen oxides and fine particulate matter
    Sarah B Henderson
    School of Occupational and Environmental Hygiene, The University of British Columbia, Vancouver, British Columbia, Canada
    Environ Sci Technol 41:2422-8. 2007
    ..62 and were similar across traffic metrics. Resulting maps show the distribution of NO to be more heterogeneous than that of NO2, supporting the usefulness of this approach for assessing spatial patterns of traffic-related pollution...
  18. ncbi Exposure to diesel exhaust up-regulates iNOS expression in ApoE knockout mice
    Ni Bai
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    Toxicol Appl Pharmacol 255:184-92. 2011
    ....
  19. pmc Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions
    Stefan Barath
    Department of Public Health and Clinical Medicine, Umea University, Sweden
    Part Fibre Toxicol 7:19. 2010
    ..Controlled human exposure studies have demonstrated impaired vascular function after inhalation of exhaust generated by a diesel engine under idling conditions...
  20. ncbi Diesel exhaust induces systemic lipid peroxidation and development of dysfunctional pro-oxidant and pro-inflammatory high-density lipoprotein
    Fen Yin
    Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 33:1153-61. 2013
    ..To evaluate whether exposure to air pollutants induces oxidative modifications of plasma lipoproteins, resulting in alteration of the protective capacities of high-density lipoproteins (HDLs)...
  21. pmc Blood pressure response to controlled diesel exhaust exposure in human subjects
    Kristen E Cosselman
    University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, WA 98105, USA
    Hypertension 59:943-8. 2012
    ..This controlled trial in humans confirms findings from observational studies. The effect may be important on a population basis given the worldwide prevalence of exposure to traffic-related air pollution...
  22. ncbi Ambient air pollution and preterm birth in the environment and pregnancy outcomes study at the University of California, Los Angeles
    Beate Ritz
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095, USA
    Am J Epidemiol 166:1045-52. 2007
    ..These results confirm the importance of reducing exposure misclassification when evaluating the effect of traffic-related pollutants that vary spatially...
  23. ncbi A controlled inhalation diesel exhaust exposure facility with dynamic feedback control of PM concentration
    Timothy Gould
    Department of Civil and Environmental Engineering, University of Washington, Seattle, Washington 98195 2700, USA
    Inhal Toxicol 20:49-52. 2008
    ..The facility enables study of the relationship between diesel exhaust and cardiovascular and respiratory health effects in human and animal models...
  24. ncbi Integrated assessment of heavy metal (Pb, Zn, Cd) highway pollution: bioaccumulation in soil, Graminaceae and land snails
    Bénédicte Viard
    Laboratoire BFE Equipe PEE, Universite de Metz, Campus Bridoux, 2 rue du général Delestraint, 57070 Metz, France
    Chemosphere 55:1349-59. 2004
    ..8 mg Zn kg(-1) DW. The levels measured decreased with increasing distance from the highway. Results of the three metals studied indicated that lead seems to be the best metal to evaluate road transport contamination...
  25. pmc Linking oxidative events to inflammatory and adaptive gene expression induced by exposure to an organic particulate matter component
    Wan Yun Cheng
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 120:267-74. 2012
    ..Toxicological studies have correlated inflammatory effects of diesel exhaust particles (DEP) with its organic constituents, such as the organic electrophile 1,2-naphthoquinone (1,2-NQ)...
  26. pmc Diesel exhaust activates and primes microglia: air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity
    Shannon Levesque
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, Virginia, USA
    Environ Health Perspect 119:1149-55. 2011
    ..Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood...
  27. ncbi Heavy metal concentrations in roadside soils and correlation with urban traffic in Beijing, China
    Xi Chen
    School of Environment, Beijing Normal University State Key Laboratory of Water Environment Simulation, Beijing, China
    J Hazard Mater 181:640-6. 2010
    ..The heavy metals could move with wind along the wind direction and the soil samples had higher heavy metal concentrations at the downwind direction...
  28. pmc Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California
    Jun Wu
    Program in Public Health, College of Health Sciences, University of California, Irvine, California 92697 7555, USA
    Environ Health Perspect 117:1773-9. 2009
    ..Increasing evidence suggests that air pollution adversely affects pregnancy outcomes. Yet few studies have examined how local traffic-generated emissions affect preeclampsia in addition to preterm birth...
  29. pmc Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo
    Jinming Liu
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Toxicol Sci 102:76-81. 2008
    ..This study is the first to demonstrate that inhaled environmental exposures influence methylation of Th genes in vivo, supporting a new paradigm in asthma pathogenesis...
  30. pmc Childhood incident asthma and traffic-related air pollution at home and school
    Rob McConnell
    University of Southern California, Los Angeles, California, USA
    Environ Health Perspect 118:1021-6. 2010
    ..Traffic-related air pollution has been associated with adverse cardiorespiratory effects, including increased asthma prevalence. However, there has been little study of effects of traffic exposure at school on new-onset asthma...
  31. ncbi Association of black carbon with cognition among children in a prospective birth cohort study
    S Franco Suglia
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Epidemiol 167:280-6. 2008
    ..9, 95% CI: -7.5, -0.3) of the Wide Range Assessment of Memory and Learning. Higher levels of black carbon predicted decreased cognitive function across assessments of verbal and nonverbal intelligence and memory constructs...
  32. ncbi Traffic-related air pollution and the development of asthma and allergies during the first 8 years of life
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, The Netherlands
    Am J Respir Crit Care Med 181:596-603. 2010
    ..The role of air pollution exposure in the development of asthma, allergies, and related symptoms remains unclear, due in part to the limited number of prospective cohort studies with sufficiently long follow-ups addressing this problem...
  33. ncbi Neighbourhood socioeconomic status, maternal education and adverse birth outcomes among mothers living near highways
    M Genereux
    Community Medicine Residency Program, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    J Epidemiol Community Health 62:695-700. 2008
    ..We evaluated whether proximity to highway interacts with individual and neighbourhood socioeconomic status (SES) to influence birth outcomes...
  34. pmc Traffic-related air pollution and QT interval: modification by diabetes, obesity, and oxidative stress gene polymorphisms in the normative aging study
    Emmanuel S Baja
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 118:840-6. 2010
    ..Acute exposure to ambient air pollution has been associated with acute changes in cardiac outcomes, often within hours of exposure...
  35. ncbi Roles of reactive oxygen species and heme oxygenase-1 in modulation of alveolar macrophage-mediated pulmonary immune responses to Listeria monocytogenes by diesel exhaust particles
    Xuejun J Yin
    School of Pharmacy, West Virginia University, 1 Medical Center Drive, Morgantown, WV 26506, USA
    Toxicol Sci 82:143-53. 2004
    ..The results also suggest that HO-1 may play an important role in regulating production of IL-10 by DEP-exposed and L. monocytogenes-infected AM...
  36. pmc Association of biomarkers of systemic inflammation with organic components and source tracers in quasi-ultrafine particles
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California 92617 7555, USA
    Environ Health Perspect 118:756-62. 2010
    ..25 microm in aerodynamic diameter (PM0.25) in a panel cohort study of 60 elderly subjects with coronary artery disease living in the Los Angeles Basin...
  37. ncbi Potentially toxic metal contamination of urban soils and roadside dust in Shanghai, China
    Guitao Shi
    Key Laboratory of Geographic Information Science of Ministry of Education, East China Normal University, Shanghai 200062, China
    Environ Pollut 156:251-60. 2008
    ....
  38. pmc Influence of traffic activity on heavy metal concentrations of roadside farmland soil in mountainous areas
    Fan Zhang
    Key Laboratory of Tibetan Environment Changes and Land Surface Processes, Institute of Tibetan Plateau, Chinese Academy of Sciences, Beijing 100080, China
    Int J Environ Res Public Health 9:1715-31. 2012
    ..However, the attenuation pattern of heavy metal concentrations as a function of roadside distance within a 100 m range cannot be identified consistently...
  39. pmc Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation
    Nicholas L Mills
    The BHF University Centre for Cardiovascular Science, Edinburgh University, The Queens Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Eur Heart J 32:2660-71. 2011
    ..We assess the role of combustion-derived-nanoparticles in mediating the adverse cardiovascular effects of air pollution...
  40. ncbi Particle traps prevent adverse vascular and prothrombotic effects of diesel engine exhaust inhalation in men
    Andrew J Lucking
    University of Edinburgh, Royal Infirmary, 49 Little France Crescent, Edinburgh, UK
    Circulation 123:1721-8. 2011
    ..The aim of the present study was to establish whether an exhaust particle trap could prevent these adverse cardiovascular effects in men...
  41. ncbi Particulate matter in new technology diesel exhaust (NTDE) is quantitatively and qualitatively very different from that found in traditional diesel exhaust (TDE)
    Thomas W Hesterberg
    Navistar, Inc, Chicago, IL, USA
    J Air Waste Manag Assoc 61:894-913. 2011
    ....
  42. ncbi Chronic obstructive pulmonary disease and long-term exposure to traffic-related air pollution: a cohort study
    Zorana J Andersen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Am J Respir Crit Care Med 183:455-61. 2011
    ..Short-term exposure to air pollution has been associated with exacerbation of chronic obstructive pulmonary disease (COPD), whereas the role of long-term exposures on the development of COPD is not yet fully understood...
  43. pmc The diesel exhaust in miners study: I. Overview of the exposure assessment process
    Patricia A Stewart
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:728-46. 2010
    ..Method evaluations indicated that the final estimates were consistent with those from alternative time trend models and demonstrated moderate to high agreement with external data...
  44. pmc A cohort study of traffic-related air pollution and mortality in Toronto, Ontario, Canada
    Michael Jerrett
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California 94720 7360, USA
    Environ Health Perspect 117:772-7. 2009
    ..Chronic exposure to traffic-related air pollution (TRAP) may contribute to premature mortality, but few studies to date have addressed this topic...
  45. pmc Association of traffic-related air pollution with children's neurobehavioral functions in Quanzhou, China
    Shunqin Wang
    Department of Occupational and Environmental Health Science, School of Public Health, Peking University, Beijing, People s Republic of China
    Environ Health Perspect 117:1612-8. 2009
    ..However, few data have been reported on the effects on neurobehavioral function in children...
  46. ncbi Diesel exhaust particulate--exposed macrophages cause marked endothelial cell activation
    Catherine A Shaw
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, UK
    Am J Respir Cell Mol Biol 44:840-51. 2011
    ..We conclude that DEP has only modest direct endothelial effects. In contrast, proinflammatory cytokines released from particle-laden MDMs appear to exacerbate endothelial activation after DEP exposure...
  47. ncbi Traffic-related air pollution, preterm birth and term birth weight in the PIAMA birth cohort study
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands
    Environ Res 111:125-35. 2011
    ..Maternal exposure to air pollution has been associated with adverse pregnancy outcomes. Few studies took into account the spatial and temporal variation of air pollution levels...
  48. pmc Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain
    Damien van Berlo
    Institut für umweltmedizinische Forschung an der Heinrich Heine Universität Düsseldorf gGmbH, Dusseldorf, Germany
    Arch Toxicol 84:553-62. 2010
    ..Our study shows that a single, short-term inhalation exposure to DEE triggers region-specific gene expression changes in rat brain to an extent comparable to those observed in the lung...
  49. pmc Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier
    Anika M S Hartz
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    FASEB J 22:2723-33. 2008
    ..These experiments disclose a novel blood-brain barrier signaling pathway, with clear implications for environmental toxicology, CNS pathology, and the pharmacotherapy of CNS disorders...
  50. pmc Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain
    Miriam E Gerlofs-Nijland
    Centre for Environmental Health, National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    Part Fibre Toxicol 7:12. 2010
    ..The day after the final exposure, the brain was dissected into the following regions: cerebellum, frontal cortex, hippocampus, olfactory bulb and tubercles, and the striatum...
  51. ncbi The joint association of air pollution and noise from road traffic with cardiovascular mortality in a cohort study
    R Beelen
    Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, PO Box 80178, 3508 TD Utrecht, The Netherlands
    Occup Environ Med 66:243-50. 2009
    ..Associations between cardiovascular mortality and air pollution and noise together were investigated...
  52. pmc Does traffic exhaust contribute to the development of asthma and allergic sensitization in children: findings from recent cohort studies
    Lennart Bråbäck
    Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
    Environ Health 8:17. 2009
    ..Future studies should also evaluate effects of traffic exhaust on the development and long term outcome of different phenotypes of asthma and wheezing symptoms...
  53. pmc Traffic-related air pollution and blood pressure in elderly subjects with coronary artery disease
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, CA 92617, USA
    Epidemiology 21:396-404. 2010
    ..We address these gaps in a study of 64 elderly subjects with coronary artery disease, living in retirement communities in the Los Angeles basin...
  54. ncbi Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase
    M L Block
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 18:1618-20. 2004
    ..Together, these in vitro data indicate that DEP selectively damages DA neurons through the phagocytic activation of microglial NADPH oxidase and consequent oxidative insult...
  55. ncbi Human health effects of air pollution
    Marilena Kampa
    Laboratory of Experimental Endocrinology, University of Crete, School of Medicine, Heraklion, Greece
    Environ Pollut 151:362-7. 2008
    ..In addition, short- and long-term exposures have also been linked with premature mortality and reduced life expectancy. These effects of air pollutants on human health and their mechanism of action are briefly discussed...
  56. pmc Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity
    Tian Xia
    Division of Clinical Immunology and Allergy, Department of Medicine, UCLA School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1680, USA
    Environ Health Perspect 112:1347-58. 2004
    ..In contrast, commercial polystyrene nanoparticles failed to exert mitochondrial effects. These results suggest that DEP and UFP effects on the PTP and Delta-Psi m are mediated by adsorbed chemicals rather than the particles themselves...
  57. pmc The effects of components of fine particulate air pollution on mortality in california: results from CALFINE
    Bart Ostro
    Office of Environmental Health Hazard Assessment, 16th Floor, 1515 Clay St, Oakland, CA 94612, USA
    Environ Health Perspect 115:13-9. 2007
    ..5 pm in diameter (PM2.5). Little is known, however, about the relative effects of PM2.5 constituents. We examined associations between 19 PM2.5 components and daily mortality in six California counties...
  58. pmc Traffic-related air pollution and acute changes in heart rate variability and respiratory function in urban cyclists
    Scott Weichenthal
    Air Health Sciences Division, Health Canada, Ottawa, Canada
    Environ Health Perspect 119:1373-8. 2011
    ..Few studies have examined the acute health effects of air pollution exposures experienced while cycling in traffic...
  59. pmc Chronic residential exposure to particulate matter air pollution and systemic inflammatory markers
    Barbara Hoffmann
    Institute for Medical Informatics, Biometry, and Epidemiology, University of Duisburg Essen, Essen, Germany
    Environ Health Perspect 117:1302-8. 2009
    ..Long-term exposure to urban air pollution may accelerate atherogenesis, but mechanisms are still unclear. The induction of a low-grade systemic inflammatory state is a plausible mechanistic pathway...
  60. pmc Lung cancer incidence and long-term exposure to air pollution from traffic
    Ole Raaschou-Nielsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Environ Health Perspect 119:860-5. 2011
    ..Previous studies have shown associations between air pollution and risk for lung cancer...
  61. ncbi Long-term exposure to close-proximity air pollution and asthma and allergies in urban children
    C Pénard-Morand
    UMR S 707, Inserm UPMC Paris 6, Medical School St Antoine, 27 rue de Chaligny, 75571, Paris, Cedex 12, France
    Eur Respir J 36:33-40. 2010
    ..4 (1.0-2.0)), and for sensitisation to pollens with volatile organic compounds (1.3 (1.0-1.9)) and PM(10) (1.2 (1.0-1.9)). Accurately modelled urban air pollution was associated with some measures of childhood asthma and allergies...
  62. pmc Factors influencing the spatial extent of mobile source air pollution impacts: a meta-analysis
    Ying Zhou
    Department of Environmental Health, Harvard School of Public Health, Landmark Center, Boston, MA 02215, USA
    BMC Public Health 7:89. 2007
    ..This review attempts to quantitatively synthesize findings about the spatial extent under various circumstances...
  63. ncbi Association of traffic-related air pollution with cognitive development in children
    Carmen Freire
    Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, 18071 Granada, Spain
    J Epidemiol Community Health 64:223-8. 2010
    ..This study aimed to investigate the association between exposure to nitrogen dioxide (NO(2)), as a marker of traffic-related air pollution, and cognitive development in children...
  64. pmc Predicting traffic-related air pollution in Los Angeles using a distance decay regression selection strategy
    Jason G Su
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, USA
    Environ Res 109:657-70. 2009
    ..g., > 5000 m from expressway) and high background concentrations in certain geographic areas. This paper represents the first attempt to model traffic-related air pollutants at a fine scale within such a complex and large urban region...
  65. pmc Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals
    Mark R Miller
    Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 117:611-6. 2009
    ..Diesel exhaust particulate (DEP) is a key arbiter of the adverse cardiovascular effects of air pollution...
  66. ncbi Exposure to traffic and the onset of myocardial infarction
    Annette Peters
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    N Engl J Med 351:1721-30. 2004
    ..This study was designed to assess whether exposure to traffic can trigger myocardial infarction...
  67. ncbi A study of the relationships between Parkinson's disease and markers of traffic-derived and environmental manganese air pollution in two Canadian cities
    Murray M Finkelstein
    McMaster University and University of Toronto, Canada
    Environ Res 104:420-32. 2007
    ..Examination of prevalence curves suggested that exposure to ambient Mn advances the age of diagnosis of PD, consistent with the theory that exposure to Mn adds to the natural loss of neurons attributable to the aging process...
  68. ncbi Novel object recognition ability in female mice following exposure to nanoparticle-rich diesel exhaust
    Tin Tin Win-Shwe
    Center for Environmental Health Sciences, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Appl Pharmacol 262:355-62. 2012
    ..The present study suggests that genes related to glutamate metabolism may be involved in the NRDE-induced neurotoxicity observed in the present mouse model...
  69. ncbi Traffic air pollution and oxidatively generated DNA damage: can urinary 8-oxo-7,8-dihydro-2-deoxiguanosine be considered a good biomarker? A meta-analysis
    Daniele Lettieri Barbato
    Food and Nutrition Unit, IRCCS San Raffaele Pisana, Rome, Italy
    Biomarkers 15:538-45. 2010
    ..This difference was clearer when an HPLC assay was used. These results show that urinary 8oxodG can be used as a biomarker to evaluate the pro-oxidant effects of vehicle exhaust emissions on DNA in exposed workers...
  70. pmc Evaluation of the public health impacts of traffic congestion: a health risk assessment
    Jonathan I Levy
    Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA
    Environ Health 9:65. 2010
    ....
  71. ncbi Divergent electrocardiographic responses to whole and particle-free diesel exhaust inhalation in spontaneously hypertensive rats
    Christina M Lamb
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina 27514, USA
    Toxicol Sci 125:558-68. 2012
    ..g., gases), whereas others (e.g., PM) trigger delayed effects potentially via separate mechanisms...
  72. pmc Comparative toxicity of size-fractionated airborne particulate matter collected at different distances from an urban highway
    Seung Hyun Cho
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 117:1682-9. 2009
    ..Epidemiologic studies have reported an association between proximity to highway traffic and increased cardiopulmonary illnesses...
  73. pmc Air pollution & the brain: Subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease
    Shannon Levesque
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298, USA
    J Neuroinflammation 8:105. 2011
    ..Increasing evidence links diverse forms of air pollution to neuroinflammation and neuropathology in both human and animal models, but the effects of long-term exposures are poorly understood...
  74. ncbi Determination of heavy metal concentrations in street dusts in Istanbul E-5 highway
    Naim Sezgin
    Faculty of Engineering, Department of Environmental Engineering, Istanbul University, 34850 Avcilar, Istanbul, Turkey
    Environ Int 29:979-85. 2004
    ..This situation indicates that there is heavy metal pollution in the inspected area in E-5 Highway in Istanbul...
  75. pmc Heterozygosity in the glutathione synthesis gene Gclm increases sensitivity to diesel exhaust particulate induced lung inflammation in mice
    Chad S Weldy
    Department of Environmental and Occupational Health, University of Washington, Seattle, WA 98195, USA
    Inhal Toxicol 23:724-35. 2011
    ..In humans, relatively common genetic polymorphisms in both the catalytic (Gclc) and modifier (Gclm) subunits of GCL have been associated with increased risk for lung and cardiovascular diseases...
  76. pmc Vehicular emissions induce vascular MMP-9 expression and activity associated with endothelin-1-mediated pathways
    Amie K Lund
    Lovelace Respiratory Research Institute, Department of Toxicology, Albuquerque, NM 87108, USA
    Arterioscler Thromb Vasc Biol 29:511-7. 2009
    ....
  77. ncbi Evaluation of the direct systemic and cardiopulmonary effects of diesel particles in spontaneously hypertensive rats
    Abderrahim Nemmar
    Department of Physiology, United Arab Emirates University, Al Ain, United Arab Emirates
    Toxicology 262:50-6. 2009
    ..We conclude that, in SHR, the presence of DEP in the systemic circulation leads not only to cardiac and systemic changes, but also triggers pulmonary inflammatory reaction involving IL-6, LTB4 and oxidative stress...
  78. ncbi Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers
    S Salvi
    University Medicine Department, Southampton General Hospital, Southampton, and Cardiovascular Research, The Rayne Institute, St Thomas Hospital, London, United Kingdom
    Am J Respir Crit Care Med 159:702-9. 1999
    ....
  79. ncbi Residential proximity to heavy traffic and birth weight in Shizuoka, Japan
    Saori Kashima
    Department of Public Health and Health Policy, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Environ Res 111:377-87. 2011
    ..Although there are many limitations, we did not find clear associations between birth-weight-related outcomes and the three markers of traffic-related air pollution...
  80. ncbi Nanoparticle-rich diesel exhaust affects hippocampal-dependent spatial learning and NMDA receptor subunit expression in female mice
    Tin Tin Win-Shwe
    Center for Environmental Risk Research, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, Japan
    Nanotoxicology 6:543-53. 2012
    ..These results indicate that three months of exposure to NRDE affected spatial learning and memory function-related gene expressions in the female mouse hippocampus...
  81. ncbi Grain size distribution of road-deposited sediment and its contribution to heavy metal pollution in urban runoff in Beijing, China
    Hongtao Zhao
    State Key Laboratory of Urban and Regional Ecology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Shuangqing Road 18, Beijing 100085, China
    J Hazard Mater 183:203-10. 2010
    ..The heavy metal content in the TSS was 2.21-6.52% of that in the RDS. These findings will facilitate our understanding of the importance of RDS grain size distribution in heavy metal pollution caused by urban storm runoff...
  82. pmc Glutathione (GSH) and the GSH synthesis gene Gclm modulate plasma redox and vascular responses to acute diesel exhaust inhalation in mice
    Chad S Weldy
    Department of Environmental and Occupational Health Sciences, University of Washington, Box 354695, Seattle, WA 98195, USA
    Inhal Toxicol 25:444-54. 2013
    ..The rate-limiting enzyme in GSH synthesis is glutamate cysteine ligase and polymorphisms in its catalytic and modifier subunits (GCLC and GCLM) have been shown to influence vascular function and risk of myocardial infarction in humans...
  83. ncbi Occupational exposure to diesel and gasoline emissions and lung cancer in Canadian men
    Paul J Villeneuve
    Population Studies Division, Health Canada, Ottawa, Ontario, Canada
    Environ Res 111:727-35. 2011
    ..Our findings suggest that exposure to diesel engine emissions increases the risk of lung cancer particularly for squamous and large cell carcinoma subtypes...
  84. ncbi Source apportionment of polycyclic aromatic hydrocarbons in the urban atmosphere: a comparison of three methods
    Randolph K Larsen
    Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, 1 Williams Street, Solomons, Maryland 20688, USA
    Environ Sci Technol 37:1873-81. 2003
    ..These methods indicate the number and relative strength of PAH sources to the ambient urban atmosphere. As with all source apportionment techniques, these methods require the user to objectively interpret the resulting source profiles...
  85. ncbi Diesel motor emissions and lung cancer mortality--results of the second follow-up of a cohort study in potash miners
    Angela Neumeyer-Gromen
    Unit Work related diseases occupational diseases, Federal Institute for Occupational Safety and Health, Berlin, Germany mail
    Int J Cancer 124:1900-6. 2009
    ..The analyses of a sub-cohort (n = 3,335) with particularly accurate exposure measurement revealed a nonsignificant dose-response-relationship. Our results support an association of DME and lung cancer mortality...
  86. pmc TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles
    Jinju Li
    Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    Environ Health Perspect 119:784-93. 2011
    ..Human respiratory epithelia function in airway mucociliary clearance and barrier function and have recently been implicated in sensory functions...
  87. pmc TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust
    Mehdi S Hazari
    Environmental Public Health Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 119:951-7. 2011
    ..Diesel exhaust (DE), which is emitted from on- and off-road sources, is a complex mixture of toxic gaseous and particulate components that leads to triggered adverse cardiovascular effects such as arrhythmias...
  88. pmc Symptoms and medication use in children with asthma and traffic-related sources of fine particle pollution
    Janneane F Gent
    Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Environ Health Perspect 117:1168-74. 2009
    ..5))] is a potential factor in the exacerbation of asthma. National air quality particle standards consider total mass, not composition or sources, and may not protect against health impacts related to specific components...
  89. ncbi Pulmonary exposure to diesel exhaust particles promotes cerebral microvessel thrombosis: protective effect of a cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid
    Abderrahim Nemmar
    Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P O Box 17666, Al Ain, United Arab Emirates
    Toxicology 263:84-92. 2009
    ..OTC pretreatment abrogated these effects through its ability to balance oxidant-antioxidant status...
  90. ncbi Respiratory health effects of diesel particulate matter
    Zoran D Ristovski
    International Laboratory for Air Quality and Health School of Engineering Systems, Queensland University of Technology, Queensland, Australia
    Respirology 17:201-12. 2012
    ..Understanding the mechanisms of lung injury from DPM will enhance efforts to protect at-risk individuals from the harmful respiratory effects of air pollutants...
  91. ncbi Acute cardiovascular and inflammatory toxicity induced by inhalation of diesel and biodiesel exhaust particles
    Jôse Mára Brito
    Department of Pathology, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Toxicol Sci 116:67-78. 2010
    ..01), B50, and B100 (p < 0.05) compared with control. Biodiesel was more toxic than diesel because it promoted cardiovascular alterations as well as pulmonary and systemic inflammation...
  92. pmc Placental mitochondrial DNA content and particulate air pollution during in utero life
    Bram G Janssen
    Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium
    Environ Health Perspect 120:1346-52. 2012
    ..Studies emphasize the importance of particulate matter (PM) in the formation of reactive oxygen species and inflammation. We hypothesized that these processes can influence mitochondrial function of the placenta and fetus...
  93. pmc Assessing the influence of traffic-related air pollution on risk of term low birth weight on the basis of land-use-based regression models and measures of air toxics
    Jo Kay C Ghosh
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, USA
    Am J Epidemiol 175:1262-74. 2012
    ..This analysis highlights the importance of both spatial and temporal contributions to air pollution in epidemiologic birth outcome studies...
  94. ncbi Assessment of heavy metals contamination and leaching characteristics in highway side soils, Iran
    Mohsen Saeedi
    Environmental Research Laboratory, Department of Hydraulics and Environment, College of Civil Engineering, Iran University of Science and Technology, Narmak, Tehran, 16846, Iran
    Environ Monit Assess 151:231-41. 2009
    ..Use of leaded gasoline and tire erosion gives a boost to this claim...
  95. pmc Socioeconomic position and health status of people who live near busy roads: the Rome Longitudinal Study (RoLS)
    Giulia Cesaroni
    Department of Epidemiology of the Regional Health Service, Lazio Region, Via S, Costanza 53, 00198 Rome, Italy
    Environ Health 9:41. 2010
    ..The issue has large public health consequences but few studies have described the main socio-demographic characteristics of people exposed to traffic...
  96. pmc The Diesel Exhaust in Miners Study: II. Exposure monitoring surveys and development of exposure groups
    Joseph B Coble
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:747-61. 2010
    ....
  97. ncbi Comparison of exposure assessment methods for occupational carcinogens in a multi-centre lung cancer case-control study
    Susan Peters
    Institute for Risk Assessment Sciences, Environmental Epidemiology Division, Utrecht University, Utrecht, The Netherlands
    Occup Environ Med 68:148-53. 2011
    ..Different methods have been developed, including case-by-case expert assessment and job-exposure matrices (JEM). The present analyses compare exposure prevalence and risk estimates derived by different exposure assessment methods...
  98. ncbi Respiratory effects of exposure to diesel traffic in persons with asthma
    James McCreanor
    National Heart and Lung Institute, Imperial College, and Royal Brompton Hospital, London, United Kingdom
    N Engl J Med 357:2348-58. 2007
    ..We investigated the effects of short-term exposure to diesel traffic in people with asthma in an urban, roadside environment...
  99. ncbi Air pollution from traffic and risk for lung cancer in three Danish cohorts
    Ole Raaschou-Nielsen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark
    Cancer Epidemiol Biomarkers Prev 19:1284-91. 2010
    ..The purpose was to investigate whether the concentration of nitrogen oxides (NOx) at the residence, used as an indicator of air pollution from traffic, is associated with risk for lung cancer...
  100. ncbi Diesel exhaust inhalation does not affect heart rhythm or heart rate variability
    Nicholas L Mills
    Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK
    Heart 97:544-50. 2011
    ..This study was undertaken to determine the effect of diesel exhaust inhalation on heart rhythm and heart rate variability in healthy volunteers and patients with coronary heart disease...
  101. ncbi Diesel exhaust particulate (DEP) and nanoparticle exposures: what do DEP human clinical studies tell us about potential human health hazards of nanoparticles?
    Thomas W Hesterberg
    Navistar, Inc, Chicago, Illinois 60601, USA
    Inhal Toxicol 22:679-94. 2010
    ....

Research Grants64

  1. Socioeconomic Status, Stress, Air Pollution and Asthma
    Rob McConnell; Fiscal Year: 2006
    ....
  2. Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children
    Toby C Lewis; Fiscal Year: 2013
    ..2 million people in the United States, thus pointing the way towards targeted therapies and public health approaches. ..
  3. Enhancement of Coronary Constriction by Volatile Organic Air Toxics
    Matthew J Campen; Fiscal Year: 2013
    ..Here, we hypothesize that combining PM with the gaseous portion of motor vehicle emissions will enhance vascular toxicity in a manner dependent on the surface area and composition of the PM...
  4. Exposure to Traffic-Related Air Pollution and to Disability in Older Adults
    Jennifer Weuve; Fiscal Year: 2013
    ..routes, along with the traffic count data) and exposure to oxides of nitrogen (NOx), a major component of vehicle emissions. In CHAP, DTR will gauge long-term exposure, because the area's roads and bus routes have been in place ..
  5. Effects of Traffic-Related Air Pollution on Cognitive Function, Dementia Risk, an
    JOEL DANIEL KAUFMAN; Fiscal Year: 2011
    ..and risk of cardiovascular disease, we will expand upon estimates of exposure to air pollutants produced by vehicle emissions to evaluate the relationship between air pollution and neurological outcomes...
  6. Ambient Air Toxics and Adverse Birth Outcomes
    MICHELLE WILHELM TURNER; Fiscal Year: 2010
    ..The expected growth in motor vehicle usage in both developed and developing countries underscore the public health relevance of traffic sources of air pollution and their impact on fetal development. ..
  7. Assessing and Reducing Taxi Drivers'Exposure to Ultrafine Particles
    Yifang Zhu; Fiscal Year: 2013
    ....
  8. Indoor and Outdoor NO2 and Asthma Severity in Children
    Brian Leaderer; Fiscal Year: 2009
    ..suggest that nitrogen dioxide (NO2) associated indoors with gas appliance use and outdoors with motor vehicle emissions, at levels well below the EPA Air Quality Standard, may be associated with respiratory symptoms in children ..
  9. Diesel Exhaust Particle Modulation of Inflammation
    Jeanclare Seagrave; Fiscal Year: 2005
    ....
  10. ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUT
    RALPH DELFINO; Fiscal Year: 2001
    ..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
  11. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    ..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
  12. Language, Literacy, Culture: Communication of Health Concepts
    DOUGLAS BRUGGE; Fiscal Year: 2006
    ....
  13. Predictors of Spatial Patterns in Urban Air Pollution
    Jonathan Levy; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  14. Solvent Exposure: Functional Imaging and Behavior
    Nancy Fiedler; Fiscal Year: 2006
    ..abstract_text> ..
  15. STATISTICAL APPROACHES TO THE STUDY OF GXE INTERACTIONS
    W Gauderman; Fiscal Year: 2002
    ..Successful completion of these aims will improve our understanding of how GxE interaction influences disease risk, and how we can optimally design studies and analyze data to find and characterize such genes. ..
  16. CCSP Promoter Function and Tumor Necrosis Factor
    KEVIN HARROD; Fiscal Year: 2006
    ..abstract_text> ..
  17. Proteomics of DEP-induced Oxidative Stress
    Andre Nel; Fiscal Year: 2006
    ..They will also use a display of protein carbonyls to identity oxidatively modified proteins in the BAL fluid. ..
  18. Air Pollution and Adverse Birth Outcomes
    Beate Ritz; Fiscal Year: 2004
    ..abstract_text> ..
  19. CCSP IN INNATE DEFENSE AGAINST LUNG VIRAL INFECTION
    KEVIN HARROD; Fiscal Year: 2003
    ..This application will determine the role and delineate mechanisms by which CCSP provides innate immunity to viral infection in the lung. Such data may be useful in designing treatment and prevention of viral pneumonia. ..
  20. Air Pollution, Inflammation and New Onset Asthma
    Frank Gilliland; Fiscal Year: 2009
    ....
  21. A Genome-wide Association Study of Childhood Respiratory Outcomes
    WILLIAM GAUDERMAN; Fiscal Year: 2009
    ..End of Abstract) ..
  22. FACTORS IN CHILDHOOD LUNG SUSCEPTIBILITY TO POLLUTION
    Frank Gilliland; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Lipids rafts in JNK and Nk-kB activation by TCR/CD28
    Andre Nel; Fiscal Year: 2006
    ..We will compare T-cells from young and elderly human subjects to determine how altered cytoskeletal assembly contributes to signaling decline by the TCR. ..
  24. Health Effects of Violence Exposure Among Children Living in Urban Environments
    Shakira Franco; Fiscal Year: 2005
    ..The proposed research involves secondary data analysis conducted withing the Maternal-Infant Smoking Study of East Boston (MISSEB) Cohort (RJ Wright, PI) and will incorporate both social and environmental frameworks. ..
  25. Development of methods and models for nanoparticle toxicity screening: Applicatio
    Andre Nel; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  26. Biological Analysis of Toxic DEP Chemicals
    Andre Nel; Fiscal Year: 2006
    ..We will determine if inhaled ambient PM induce apoptosis in induced sputum samples in humans. ..
  27. Registry Study of Parkinsons Disease in Denmark
    Beate R Ritz; Fiscal Year: 2010
    ..The proposed research cannot be performed in the US due to a lack of population PD registries that would provide access to such a large number of cases and valid methods for control recruitment from the general population. ..
  28. Atherogenic Effects of Ambient PM In Susceptible Animals
    Andre Nel; Fiscal Year: 2007
    ..These mice will be exposed to CAPs as discussed in Aims 1 and 2, and select endpoints used to demonstrate the effect on atherosclerotic inflammation and apoptosis. ..
  29. Ergonomic Interventions for Garment Work
    Beate Ritz; Fiscal Year: 2004
    ..This study will provide employers, employees and public agencies with evidence of the effectiveness of ergonomic interventions in order to guide health and safety policy. ..
  30. Lead Exposure, HPA Axis Dysfunction, and Blood Pressure: Hypertension Risk
    Nancy Fiedler; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  31. Exposure Insights Using GIS in a Case-Control Study
    Peggy Reynolds; Fiscal Year: 2006
    ..Primary exposure sources of concern for this project include agricultural pesticides, motor vehicle emissions, and other sources of air toxicants...
  32. Lung Transcriptional Regulation During Disease
    KEVIN HARROD; Fiscal Year: 2007
    ....
  33. OLFACTION IN MULTIPLE SCLEROSIS
    RICHARD DOTY; Fiscal Year: 2001
    ....
  34. Cardiac vulnerability due to ambient particulate
    John Godleski; Fiscal Year: 2008
    ..Thus, the present application will entail unique application of comprehensive techniques to improve understanding of the mechanisms whereby CAPs can exert its deleterious influences on the heart and circulation [unreadable] [unreadable]..
  35. Role of CHF1 in Occlusive Vascular Disease
    Michael Chin; Fiscal Year: 2008
    ..We will cross conditional knockout mice lacking CHF1 in vascular smooth muscle with ApoE null mice and measure the development of atherosclerotic lesions in the double knockout mice. [unreadable] [unreadable]..
  36. Mechanism of Circadian Susceptibility to Pesticides
    LOUISA HOOVEN; Fiscal Year: 2008
    ..Humans are inevitably exposed to pyrethroids and other pesticides, and this interdisciplinary investigation is likely to lead to novel strategies protective of human health. [unreadable] [unreadable] [unreadable]..
  37. REGULATION OF IL4 PRODUCTION IN VIVO
    Fred Finkelman; Fiscal Year: 2002
    ..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
  38. Environmental Determinants of Sleep Disturbance: Role of Ambient Air Pollution
    Jiu Chiuan Chen; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  39. MARKERS FOR LUNG CARCINOGENESIS IN BRONCHIAL EPITHELIUM
    Steven Belinsky; Fiscal Year: 2001
    ..f., simply markers of exposure) and help identify genetic alterations that are candidate markers of respiratory carcinogenesis. ..
  40. Costs of Occupational Injury and Illness
    J Leigh; Fiscal Year: 2009
    ..But reported national injury rates have been fallen since 1992. Moreover, Workers'Compensation costs fell from 1993 to 1998 but have risen since 1999. Current and comprehensive estimates are needed. ..
  41. SCANNING ELECTRON MICROSCOPY SYSTEM
    John Godleski; Fiscal Year: 2001
    ..Institutional support is demonstrated by past support of the facility, completed renovations, commitments for ongoing service contracts, and letters of commitment for future support. ..
  42. TUMOR SUPPRESSOR GENE METHYLATION IN LUNG ADENOCARCINOMA
    Steven A Belinsky; Fiscal Year: 2010
    ..Transient transfection of minimized promoters into cell lines with an endogenously active or silenced gene will be used to elucidate the sequence of changes involved in repression of promoter activity. REVISED: July 7, 2005 ..
  43. MMP-9 Activity Mediates Vascular Effects of Inhaled Environmental Air Pollutants
    Amie Lund; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  44. Method Development for the Analysis of PBDEs in Human Placenta Tissue
    An Li; Fiscal Year: 2008
    ..A laboratory procedure is to be developed in order to understand how a wide-spread environmental pollutant affects the health of human fetus before babies are born. [unreadable] [unreadable] [unreadable]..
  45. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005
    ..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..
  46. INFLAMMATION & CORTICOSTEROID RESPONSES IN SEVERE ASTHMA
    KIAN CHUNG; Fiscal Year: 2005
    ..The molecular mechanisms underlying loss of CR will be examined. These studies should lead to more effective therapies for chronic severe asthma. ..
  47. XENOBIOTICS AND ALLERGIC INFLAMMATION
    Andrew Saxon; Fiscal Year: 2005
    ..The projects are supported by a DEP collection and fractionation core, a mouse core, and a administrative, patient and sample coordination core. ..
  48. Retrospective Assessment of Mixed Chemical Exposures
    Gurumurthy Ramachandran; Fiscal Year: 2003
    ..However, the methods will be applicable to other industry based epidemiologic studies where the available data are sparse and exposures to chemical mixtures are the norm. ..
  49. Particulate Air Pollution and Acute Ischemic Stroke
    Gregory Wellenius; Fiscal Year: 2006
    ..These hypotheses will be tested in patient populations with complimentary strengths. ..
  50. Analysis of lipids, inflammation, and pulmonary function
    GEORGE O CONNOR; Fiscal Year: 2003
    ..abstract_text> ..
  51. OLFACTION IN EPILEPSY
    RICHARD DOTY; Fiscal Year: 2004
    ..In addition to providing a better understanding of the influences of TLE and TLR on human olfactory function, this work may lead to the development of a simple and inexpensive non-invasive means for better establishing TLE seizure loci. ..
  52. Role of Inflammatory Cytokines in the Allergic Response
    Fred Finkelman; Fiscal Year: 2007
    ..abstract_text> ..
  53. Study of Genetics, Endotoxin and Allergen (SAGE)
    Karin Pacheco; Fiscal Year: 2007
    ....
  54. Expert Decision-making in Exposure Assessment
    Gurumurthy Ramachandran; Fiscal Year: 2007
    ..The methodology will be developed using a large occupational exposure dataset from 3M Company, and probabilistic professional judgments obtained from occupational hygienists employed at 3M Company. ..
  55. Passive PAH and Micro-Camera Personal Monitoring System
    Paul Lioy; Fiscal Year: 2003
    ....
  56. Air Pollution-Induced Vascular Endothelin Regulation of MMP Activity.
    Amie Lund; Fiscal Year: 2007
    ..Identification of environmental factors, and the cellular pathways they potentate, associated with cardiovascular disease progression is critical for both prevention and pharmacological therapy. [unreadable] [unreadable] [unreadable]..
  57. Health Effects of the London Congestion Charge Scheme
    Cathryn Tonne; Fiscal Year: 2008
    ..The proposed research would provide useful insight into the potential of such traffic management strategies as important public health interventions. ..
  58. CAM Approaches to Air Pollution Related Health Effects
    Jason Allen; Fiscal Year: 2007
    ..The long-term objective of this research is to rigorously examine potential CAM interventions in augmenting adverse health effects induced by pollutants that pose a substantial ongoing public health burden. ..
  59. INNER CITY COCKROACH ALLERGEN REDUCTION TRIAL
    Peyton Eggleston; Fiscal Year: 2002
    ..Secondary variables, including medication use, acute care visits, school loss, FEVI and methacholine responsiveness will also be compared. ..
  60. HOME BASED ENVIRONMENTAL ADHERENCE TRIAL
    Peyton Eggleston; Fiscal Year: 2002
    ....
  61. Socioeconomic Status, Stress & Asthma Biological Markers
    Edith Chen; Fiscal Year: 2009
    ..The results from this project will allow us to begin developing models of how the larger social environment comes to affect a child's clinical course of asthma. ..
  62. Socioeconomics Status&Respiratory/Cardiovascular Health
    Edith Chen; Fiscal Year: 2003
    ..These analyses could have implications for how to time interventions to reduce health disparities in children, and for understanding the mediators that drive the relationship between SES and childhood health. ..