smoke

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Top Publications

  1. ncbi Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
    R D Hautamaki
    Department of Internal Medicine, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, USA
    Science 277:2002-4. 1997
  2. pmc Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 31:894-901. 2010
  3. pmc IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice
    Fernando M Botelho
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Canada
    PLoS ONE 6:e28457. 2011
  4. pmc Respiratory health effects of air pollution: update on biomass smoke and traffic pollution
    Robert J Laumbach
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School and Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Allergy Clin Immunol 129:3-11; quiz 12-3. 2012
  5. pmc Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles
    Athanasios Valavanidis
    Department of Chemistry, Free Radical Research Group, University of Athens, University Campus Zografou, 15784 Athens, Greece
    Int J Environ Res Public Health 6:445-62. 2009
  6. pmc Comparison of the cytotoxic potential of cigarette smoke and electronic cigarette vapour extract on cultured myocardial cells
    Konstantinos E Farsalinos
    Onassis Cardiac Surgery Center, Sygrou 356, Kallithea 17674, Greece
    Int J Environ Res Public Health 10:5146-62. 2013
  7. ncbi Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke
    Javier Milara
    Clinical research unit UIC, University General Hospital Consortium, Valencia, Spain
    Thorax 68:410-20. 2013
  8. ncbi Cytotoxicity evaluation of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): comparison with tobacco cigarette smoke extract
    Giorgio Romagna
    Abich srl, biological and chemical toxicology research laboratory, Verbania VB, Italy
    Inhal Toxicol 25:354-61. 2013
  9. ncbi Cigarette smoke induces oxidative stress and apoptosis in normal term fetal membranes
    R Menon
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Ave NE, Atlanta, GA 30322, USA
    Placenta 32:317-22. 2011
  10. ncbi Risk of COPD from exposure to biomass smoke: a metaanalysis
    Guoping Hu
    Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, 151 Yanjiang Rd, Guangzhou, Guangdong, 510120, China
    Chest 138:20-31. 2010

Detail Information

Publications310 found, 100 shown here

  1. ncbi Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
    R D Hautamaki
    Department of Internal Medicine, Washington University School of Medicine at Barnes Jewish Hospital, St Louis, MO 63110, USA
    Science 277:2002-4. 1997
    ..characteristic of pulmonary emphysema, macrophage elastase-deficient (MME-/-) mice were subjected to cigarette smoke. In contrast to wild-type mice, MME-/- mice did not have increased numbers of macrophages in their lungs and did ..
  2. pmc Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lung
    Alberto Izzotti
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Carcinogenesis 31:894-901. 2010
    ..to evaluate the modulation of mRNA expression as related to exposure of neonatal mice to environmental cigarette smoke (ECS) and to treatment with chemopreventive agents...
  3. pmc IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice
    Fernando M Botelho
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Canada
    PLoS ONE 6:e28457. 2011
    ..Despite this, the cellular and molecular mechanisms that contribute to COPD pathogenesis are still poorly understood...
  4. pmc Respiratory health effects of air pollution: update on biomass smoke and traffic pollution
    Robert J Laumbach
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School and Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Allergy Clin Immunol 129:3-11; quiz 12-3. 2012
    ..Physicians can help to reduce the risk of adverse respiratory effects of exposure to biomass and traffic air pollutants by promoting awareness and supporting individual and community-level interventions...
  5. pmc Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles
    Athanasios Valavanidis
    Department of Chemistry, Free Radical Research Group, University of Athens, University Campus Zografou, 15784 Athens, Greece
    Int J Environ Res Public Health 6:445-62. 2009
    Tobacco smoke contains many toxic, carcinogenic and mutagenic chemicals, as well as stable and unstable free radicals and reactive oxygen species (ROS) in the particulate and the gas phase with the potential for biological oxidative ..
  6. pmc Comparison of the cytotoxic potential of cigarette smoke and electronic cigarette vapour extract on cultured myocardial cells
    Konstantinos E Farsalinos
    Onassis Cardiac Surgery Center, Sygrou 356, Kallithea 17674, Greece
    Int J Environ Res Public Health 10:5146-62. 2013
    ..Smoking is an important risk factor for cardiovascular disease and cigarette smoke (CS) has well-established cytotoxic effects on myocardial cells...
  7. ncbi Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke
    Javier Milara
    Clinical research unit UIC, University General Hospital Consortium, Valencia, Spain
    Thorax 68:410-20. 2013
    ..This study examines the EMT process in human bronchial epithelial cells (HBECs) from non-smokers, smokers and patients with COPD as well as the in vitro effect of cigarette smoke extract (CSE) on EMT.
  8. ncbi Cytotoxicity evaluation of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): comparison with tobacco cigarette smoke extract
    Giorgio Romagna
    Abich srl, biological and chemical toxicology research laboratory, Verbania VB, Italy
    Inhal Toxicol 25:354-61. 2013
    ..Electronic cigarettes (ECs) are used as alternatives to smoking; however, data on their cytotoxic potential are scarce...
  9. ncbi Cigarette smoke induces oxidative stress and apoptosis in normal term fetal membranes
    R Menon
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Ave NE, Atlanta, GA 30322, USA
    Placenta 32:317-22. 2011
    ..We hypothesized that exposure of fetal membranes to cigarette smoke extracts might induce oxidative stress (OS) and fetal membrane apoptosis, culminating in an alternate pathway to ..
  10. ncbi Risk of COPD from exposure to biomass smoke: a metaanalysis
    Guoping Hu
    Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, 151 Yanjiang Rd, Guangzhou, Guangdong, 510120, China
    Chest 138:20-31. 2010
    Although many studies have suggested that biomass smoke is a risk factor for COPD, the relationship between the two has not been firmly established...
  11. ncbi Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent
    Emilie Doz
    University of Orleans and Centre National de la Recherche Scientifique UMR6218, Molecular Immunology and Embryology, France
    J Immunol 180:1169-78. 2008
    Acute cigarette smoke exposure of the airways (two cigarettes twice daily for three days) induces acute inflammation in mice. In this study, we show that airway inflammation is dependent on Toll-like receptor 4 and IL-1R1 signaling...
  12. ncbi Woodsmoke health effects: a review
    Luke P Naeher
    Department of Environmental Health Science, College of Public Health, University of Georgia, Athens, Georgia, USA
    Inhal Toxicol 19:67-106. 2007
    ..we examine several topics: the chemical and physical nature of woodsmoke; the exposures and epidemiology of smoke from wildland fires and agricultural burning, and related controlled human laboratory exposures to biomass smoke; ..
  13. pmc Peat bog wildfire smoke exposure in rural North Carolina is associated with cardiopulmonary emergency department visits assessed through syndromic surveillance
    Ana G Rappold
    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1415-20. 2011
    ..Although the association of mortality and morbidity with exposure to urban air pollution is well established, the health effects associated with exposure to wildfire emissions are less well understood...
  14. pmc Intervention to lower household wood smoke exposure in Guatemala reduces ST-segment depression on electrocardiograms
    John McCracken
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 119:1562-8. 2011
    ..RESPIRE (Randomized Exposure Study of Pollution Indoors and Respiratory Effects) was a randomized trial of a chimney woodstove that reduces wood smoke exposure.
  15. ncbi Smoke constituent exposure and stage of change in black and white women cigarette smokers
    K Ahijevych
    Ohio State University, College of Nursing, Columbus 43210, USA
    Addict Behav 24:115-20. 1999
    Differences in smoke constituent exposure by ethnicity and menthol preference and differences in decisional balance and habit strength by stage of change, ethnicity, and menthol preference were examined in this 2-factor study design...
  16. pmc Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration
    Lucy A Clunes
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    FASEB J 26:533-45. 2012
    Cigarette smoke (CS) exposure induces mucus obstruction and the development of chronic bronchitis (CB)...
  17. pmc IL-17RA is required for CCL2 expression, macrophage recruitment, and emphysema in response to cigarette smoke
    Kong Chen
    Department of Genetics, Louisiana State University Health Science Center, New Orleans, Louisiana, United States of America
    PLoS ONE 6:e20333. 2011
    ..Here we show that cigarette smoke is a selective adjuvant that augments in vitro and in vivo Th17, but not Th1, cell differentiation via the aryl ..
  18. ncbi Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate
    F Liu
    Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Oncogene 29:3650-64. 2010
    ..In this study, we established an in vitro system to examine epigenomic effects of cigarette smoke in respiratory epithelia...
  19. ncbi An air filter intervention study of endothelial function among healthy adults in a woodsmoke-impacted community
    Ryan W Allen
    Simon Fraser University, Faculty of Health Sciences, 8888 University Drive, Burnaby, British Columbia V5A 1S6, Canada
    Am J Respir Crit Care Med 183:1222-30. 2011
    ..Particulate air pollution is associated with cardiovascular morbidity. One hypothesized mechanism involves oxidative stress, systemic inflammation, and endothelial dysfunction...
  20. ncbi Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure
    Harry R Gosker
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 40:710-6. 2009
    ..Mice were exposed to cigarette smoke or control air for 6 months...
  21. ncbi Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada
    Am J Respir Cell Mol Biol 37:144-51. 2007
    We have previously observed that mice exposed to cigarette smoke and treated with exogenous alpha(1)-antitrypsin (A1AT) were protected against the development of emphysema and against smoke-induced increases in serum TNF-alpha...
  22. ncbi The role of ChemR23 in the induction and resolution of cigarette smoke-induced inflammation
    Tine Demoor
    Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    J Immunol 186:5457-67. 2011
    Chronic obstructive pulmonary disease is mainly triggered by cigarette smoke (CS) and progresses even after smoking cessation...
  23. ncbi Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells
    Adam Csordas
    Division of Experimental Pathophysiology and Immunology, Laboratory of Autoimmunity, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Cardiovasc Res 92:141-8. 2011
    Consumption of cigarette smoke (CS) is a well-known risk factor for early atherosclerosis; yet, the underlying mechanisms of smoking-associated atherosclerosis are poorly understood...
  24. ncbi Evaluation of the potential effects of ingredients added to cigarettes. Part 2: chemical composition of mainstream smoke
    K Rustemeier
    INBIFO Institut für biologische Forschung, Fuggerstr 3, D 51149, Koln, Germany
    Food Chem Toxicol 40:93-104. 2002
    Cigarette mainstream smoke from blended research cigarettes with and without the addition of ingredients was analyzed for its chemical composition...
  25. pmc Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 294:H2721-35. 2008
    ..The present study was designed to elucidate the effects of resveratrol on cigarette smoke-induced vascular oxidative stress and inflammation, which is a clinically highly relevant model of accelerated ..
  26. ncbi Differential protease, innate immunity, and NF-kappaB induction profiles during lung inflammation induced by subchronic cigarette smoke exposure in mice
    R Vlahos
    Department of Medicine, University of Melbourne, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Am J Physiol Lung Cell Mol Physiol 290:L931-45. 2006
    Cigarette smoke exposure is a major determinant of adverse lung health, but the molecular processes underlying its effects on inflammation and immunity remain poorly understood...
  27. pmc Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
    Thomas E Sussan
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 106:250-5. 2009
    ..disease (COPD), which comprises emphysema and chronic bronchitis resulting from prolonged exposure to cigarette smoke (CS), is a major public health burden with no effective treatment...
  28. ncbi Tobacco smoke exposure is associated with the metabolic syndrome in adolescents
    Michael Weitzman
    American Academy of Pediatrics Center for Child Health Research, Rochester, NY, USA
    Circulation 112:862-9. 2005
    ..Tobacco smoke potentially contributes to insulin resistance in this syndrome...
  29. ncbi Patterns of p53 G-->T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke
    P Hainaut
    International Agency for Research on Cancer WHO, 150 cours Albert Thomas, 69372 Lyon Cedex, France
    Carcinogenesis 22:367-74. 2001
    ..Our data reinforce the notion that p53 mutations in lung cancers can be attributed to direct DNA damage from cigarette smoke carcinogens rather than to selection of pre-existing endogenous mutations.
  30. ncbi Matrix metalloproteinases activity in COPD associated with wood smoke
    Martha Montaño
    Department of Molecular Biology, Instituto Nacional de Enfermedades Respiratorias, Calzada de Tlalpan 4502, CP 14080, Mexico, D F, Mexico
    Chest 125:466-72. 2004
    Wood smoke (WS) exposure causes COPD with respiratory alterations that are similar to those described for COPD associated with tobacco smoke (TS)...
  31. pmc Cigarette smoke-related hydroquinone dysregulates MCP-1, VEGF and PEDF expression in retinal pigment epithelium in vitro and in vivo
    Marianne Pons
    Department of Ophthalmology, Miller School of Medicine, Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States of America
    PLoS ONE 6:e16722. 2011
    ..We also evaluated the effects of hydroquinone (HQ), a major pro-oxidant in cigarette smoke on MCP-1, VEGF and PEDF expression in cultured ARPE-19 cells and RPE/choroids from C57BL/6 mice.
  32. pmc The role of matrix metalloproteinase-9 in cigarette smoke-induced emphysema
    Jeffrey J Atkinson
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 183:876-84. 2011
    ..Mouse models have demonstrated that excess MMP-9 production can result in permanent alveolar destruction...
  33. pmc Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes
    Jameel Iqbal
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19147, USA
    Proc Natl Acad Sci U S A 110:11115-20. 2013
    Smoking is a major risk factor for osteoporosis and fracture, but the mechanism through which smoke causes bone loss remains unclear...
  34. ncbi Matrix proteins from smoke-exposed fibroblasts are pro-proliferative
    David I Krimmer
    Woolcock Institute of Medical Research Cell Biology, Sydney, New South Wales, Australia
    Am J Respir Cell Mol Biol 46:34-9. 2012
    ..We investigated the role of cigarette smoke in altering the ECM deposited from human lung fibroblasts...
  35. pmc Lung carcinogenesis by tobacco smoke
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Cancer 131:2724-32. 2012
    Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung carcinogens...
  36. ncbi Network meta-analysis to evaluate the effectiveness of interventions to increase the uptake of smoke alarms
    Nicola J Cooper
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, United Kingdom
    Epidemiol Rev 34:32-45. 2012
    ..to simultaneously evaluate the effectiveness of interventions to increase the prevalence of functioning smoke alarms in households with children...
  37. pmc Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process
    Patrick Geraghty
    Department of Medicine, Divisions of Molecular and Pulmonary Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Int J Chron Obstruct Pulmon Dis 6:309-19. 2011
    Cigarette smoke is the major risk factor associated with the development of chronic obstructive pulmonary disease (COPD)...
  38. pmc Vapor, dust, and smoke exposure in relation to adult-onset asthma and chronic respiratory symptoms: the Singapore Chinese Health Study
    Tricia D LeVan
    Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
    Am J Epidemiol 163:1118-28. 2006
    ..These data support the role of occupational exposures in the etiology of respiratory illness in a population-based cohort in Singapore with a low prevalence of atopic illness...
  39. ncbi Effects on airways of short-term exposure to two kinds of wood smoke in a chamber study of healthy humans
    Leo Stockfelt
    Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital and Academy, University of Gothenburg, Gothenburg, Sweden
    Inhal Toxicol 24:47-59. 2012
    ..Airway inflammation may be involved in the mechanism also for cardiovascular disease. Wood smoke is a significant contributor to air pollution, with complex and varying composition...
  40. pmc Methylation of Wnt7a is modulated by DNMT1 and cigarette smoke condensate in non-small cell lung cancer
    Meredith A Tennis
    Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States of America
    PLoS ONE 7:e32921. 2012
    ..Restoration of Wnt7a expression through demethylation could be an important therapeutic approach in the treatment of NSCLC...
  41. pmc Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants
    Daniel N Willis
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut, USA
    FASEB J 25:4434-44. 2011
    ..It is highly controversial whether menthol in cigarette smoke exerts pharmacological actions affecting smoking behavior...
  42. pmc Cigarette smoke promotes dendritic cell accumulation in COPD; a Lung Tissue Research Consortium study
    Robert Vassallo
    The Thoracic Diseases Research Unit, Division of Pulmonary Critical Care, Department of Internal Medicine, the Clinical Immunology and Immunotherapeutics Program, Mayo Clinic and Foundation, Rochester, Minnesota, 55905, USA
    Respir Res 11:45. 2010
    ..Although evident that cigarette smoke, the primary cause of COPD, significantly influences dendritic cell functions, little is known about the roles of ..
  43. ncbi Cigarette smoke extract modulates human beta-defensin-2 and interleukin-8 expression in human gingival epithelial cells
    R Mahanonda
    Department of Periodontology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
    J Periodontal Res 44:557-64. 2009
    ..Their responses to stimuli are critical in maintaining periodontal homeostasis. The aim of this study was to investigate the modulating effect of cigarette smoke extract (CSE) on the innate immune responses of HGECs.
  44. ncbi Cigarette smoke condensate exposure delays follicular development and function in a stage-dependent manner
    Jean Clair Sadeu
    Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada
    Fertil Steril 95:2410-7. 2011
    To determine the effects of cigarette smoke condensate (CSC) on follicular development and function from the early preantral stage through ovulation.
  45. ncbi Oxidative stress, inflammation, and DNA damage in rats after intratracheal instillation or oral exposure to ambient air and wood smoke particulate matter
    Pernille Høgh Danielsen
    Section of Environmental Health, Department of Public Health, University of Copenhagen, DK 1014 Copenhagen, Denmark
    Toxicol Sci 118:574-85. 2010
    ..Exposure occurs through inhalation or ingestion after deposition of wood smoke particulate matter (WSPM) on crops and food...
  46. ncbi Genotoxicity of 10 cigarette smoke condensates in four test systems: comparisons between assays and condensates
    David M DeMarini
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 650:15-29. 2008
    The particulate fraction of cigarette smoke, cigarette smoke condensate (CSC), is genotoxic in many short-term in vitro tests and is carcinogenic in rodents...
  47. pmc Exposure to cigarette smoke inhibits the pulmonary T-cell response to influenza virus and Mycobacterium tuberculosis
    Yan Feng
    Center for Pulmonary and Infectious Disease Control, The University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA
    Infect Immun 79:229-37. 2011
    ..Mice were left unexposed or were exposed to cigarette smoke and then infected with Mycobacterium tuberculosis by aerosol or influenza A by intranasal infection...
  48. ncbi Reactivity of mouse alveolar macrophages to cigarette smoke is strain dependent
    Daniela Vecchio
    Dept of Physiopathology and Experimental Medicine, Univ of Siena, Italy
    Am J Physiol Lung Cell Mol Physiol 298:L704-13. 2010
    Cigarette smoke (CS) is a main risk factor in chronic obstructive pulmonary disease (COPD), but only 20% of smokers develop COPD, suggesting genetic predisposition...
  49. ncbi Cigarette smoke--an aging accelerator?
    David Bernhard
    Vascular Biology Group, Division Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
    Exp Gerontol 42:160-5. 2007
    ..In this review, we make an attempt to ascribe many of the deleterious effects of smoking on human health to a general principle, namely the acceleration of aging processes by cigarette smoke chemicals.
  50. ncbi An overview of the effects of tobacco ingredients on smoke chemistry and toxicity
    Richard R Baker
    British American Tobacco, Research and Development Centre, Regent s Park Road, Southampton SO15 8TL, UK
    Food Chem Toxicol 42:S53-83. 2004
    ..an overview of a series of studies designed to assess the influence of 482 tobacco ingredients on cigarette smoke chemistry and toxicity...
  51. pmc SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol
    Gnanapragasam Arunachalam
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Biochem Biophys Res Commun 393:66-72. 2010
    ..Cigarette smoke (CS)-mediated oxidative stress is implicated in endothelial dysfunction...
  52. pmc Indoor air pollution from biomass fuel smoke is a major health concern in the developing world
    Duncan G Fullerton
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trans R Soc Trop Med Hyg 102:843-51. 2008
    ..The mechanisms behind these associations are not fully understood. This review summarises the available information on biomass fuel use and health, highlighting the current gaps in knowledge...
  53. pmc Household air pollution from coal and biomass fuels in China: measurements, health impacts, and interventions
    Junfeng Jim Zhang
    School of Public Health, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    Environ Health Perspect 115:848-55. 2007
    ..Our objective in this review was to help elucidate the extent of this indoor air pollution health hazard...
  54. ncbi Polycyclic aromatic hydrocarbons, carbon monoxide, "tar", and nicotine in the mainstream smoke aerosol of the narghile water pipe
    Alan Shihadeh
    Aerosol Research Laboratory, Department of Mechanical Engineering, American University of Beirut, PO Box 11 0236, Riad El Solh, Beirut, Lebanon
    Food Chem Toxicol 43:655-61. 2005
    ..94 mg nicotine, 802 mg "tar", 145 mg CO, and relative to the smoke of a single cigarette, greater quantities of chrysene, phenanthrene, and fluoranthene...
  55. pmc Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents
    Eunice Andre
    Center of Excellence for the Study of Inflammation, University of Ferrara, Ferrara, Italy
    J Clin Invest 118:2574-82. 2008
    Cigarette smoke (CS) inhalation causes an early inflammatory response in rodent airways by stimulating capsaicin-sensitive sensory neurons that express transient receptor potential cation channel, subfamily V, member 1 (TRPV1) through an ..
  56. ncbi Metals in cigarette smoke
    David Bernhard
    Vascular Biology Group, Division of Experimental Pathophysiology and Immunology, Innsbruck Medical University, Austria
    IUBMB Life 57:805-9. 2005
    ..The metal content of tobacco plants, smoke, the circulation, and various organs is discussed...
  57. ncbi Personal child and mother carbon monoxide exposures and kitchen levels: methods and results from a randomized trial of woodfired chimney cookstoves in Guatemala (RESPIRE)
    Kirk R Smith
    Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720 7360, USA
    J Expo Sci Environ Epidemiol 20:406-16. 2010
    ....
  58. pmc The relationship of respiratory and cardiovascular hospital admissions to the southern California wildfires of 2003
    R J Delfino
    Epidemiology Department, School of Medicine, University of California Irvine, 100 Theory Drive, Irvine, CA 92617 7555, USA
    Occup Environ Med 66:189-97. 2009
    ..The relationship of cardiorespiratory hospital admissions (n = 40 856) to wildfire-related particulate matter (PM(2.5)) during catastrophic wildfires in southern California in October 2003 was evaluated...
  59. ncbi Oxidative stress, DNA damage, and inflammation induced by ambient air and wood smoke particulate matter in human A549 and THP-1 cell lines
    Pernille Høgh Danielsen
    Section of Environmental Health, Department of Public Health, University of Copenhagen, Denmark
    Chem Res Toxicol 24:168-84. 2011
    ..of ambient air PM, especially related to traffic, is well advanced, whereas the toxicology of wood smoke PM (WSPM) is poorly assessed...
  60. pmc Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD
    Jae Woong Hwang
    Department of Environmental Medicine, University of Rochester Medical Center, NY, USA
    Arch Biochem Biophys 500:203-9. 2010
    ..Cigarette smoke (CS)-mediated oxidative stress induces cytotoxic responses in lung cells...
  61. pmc Cigarette smoke induces C/EBP-β-mediated activation of miR-31 in normal human respiratory epithelia and lung cancer cells
    Sichuan Xi
    Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 5:e13764. 2010
    ..The present study was undertaken to examine expression and function of miRNAs induced by cigarette smoke condensate (CSC) in normal human respiratory epithelia and lung cancer cells.
  62. ncbi Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1
    Hong Pyo Kim
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, MUH 628NW, Pittsburgh, Pennsylvania, USA
    Autophagy 4:887-95. 2008
    Cigarette smoke-induced cell death contributes to the pathogenesis of chronic obstructive pulmonary disease, though the relative roles of apoptosis and autophagy remain unclear...
  63. pmc Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells
    Marco van der Toorn
    Department of Pathology and Medical Biology, Laboratory of Allergology and Pulmonary Diseases, University Medical Center Groningen, University of Groningen, The
    Am J Physiol Lung Cell Mol Physiol 297:L109-14. 2009
    Reactive oxygen species (ROS) present in cigarette smoke (CS) are thought to contribute to the development of COPD...
  64. ncbi Exposure of bronchial epithelial cells to whole cigarette smoke: assessment of cellular responses
    Jeremy Phillips
    British American Tobacco, Group R and D Centre, Southampton, UK
    Altern Lab Anim 33:239-48. 2005
    Cigarette smoke is composed of approximately 5% particulate phase and 95% vapour phase by weight. However, routine in vitro toxicological testing of smoke normally only measures the activity of the particulate phase...
  65. ncbi An analysis of effects of San Diego wildfire on ambient air quality
    Shekar Viswanathan
    School of Engineering and Technology, National University, La Jolla, CA 92037, USA
    J Air Waste Manag Assoc 56:56-67. 2006
    ..Fortunately, the absence of sunlight because of the cloud of thick smoke that covered most of the county during the fire appears to have prevented the photochemical conversion of the ..
  66. pmc DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2
    Laura L Koth
    Division of Pulmonary and Critical Care Medicine, Lung Biology Center, University of California at San Francisco, San Francisco, CA 94143, USA
    J Immunol 184:6522-8. 2010
    ..In vitro, cigarette smoke directly induced expression of myeloid DAP12-associated lectin-1 and TREM2 and activation of DAP12 signaling in ..
  67. ncbi Wood smoke exposure induces a pulmonary and systemic inflammatory response in firefighters
    J R Swiston
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Eur Respir J 32:129-38. 2008
    Epidemiological studies report an association between exposure to biomass smoke and cardiopulmonary morbidity. The mechanisms for this association are unclear...
  68. ncbi Estimating personal PM2.5 exposures using CO measurements in Guatemalan households cooking with wood fuel
    Amanda Northcross
    Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    J Environ Monit 12:873-8. 2010
    As a part of a longitudinal study in the highlands of Guatemala to elicit the chronic health effects of wood smoke from cooking, mean area and personal 48 h concentrations of 2.5 microm particulate matter (PM2...
  69. ncbi Enhancement of Candida albicans virulence after exposition to cigarette mainstream smoke
    Fernanda Brasil Baboni
    Laboratory of Stomatology, CCBS, Pontifical Catholic University of Parana, Rua Imaculada Conceição 1155, Curitiba, 80215 901, Brazil
    Mycopathologia 168:227-35. 2009
    ..The effects of exposure to smoke on the virulence properties of oral yeasts remain obscure...
  70. ncbi Improved biomass stove intervention in rural Mexico: impact on the respiratory health of women
    Isabelle Romieu
    Environmental Health Department, National Institute of Public Health INSP, Cuernavaca, Morelos, Mexico
    Am J Respir Crit Care Med 180:649-56. 2009
    Exposure to biomass smoke has been related to adverse health effects. In Mexico, one household in four still cooks with biomass fuel, but there has been no evaluation of the health impact of reducing indoor air pollution.
  71. pmc Comparison of two quantitative methods of discerning airspace enlargement in smoke-exposed mice
    Richard E Jacob
    Biological Monitoring and Modeling, Pacific Northwest National Laboratory, Richland, Washington, USA
    PLoS ONE 4:e6670. 2009
    ..two methods for evaluating and quantifying pulmonary airspace enlargement in a mouse model of chronic cigarette smoke exposure...
  72. pmc Cigarette smoke induces epidermal growth factor receptor-dependent redistribution of apical MUC1 and junctional beta-catenin in polarized human airway epithelial cells
    Ying Ting Chen
    University of California, San Francisco, Francis I Proctor Foundation, San Francisco, CA 94143, USA
    Am J Pathol 177:1255-64. 2010
    Cigarette smoke (CS) accounts for nearly 90% of lung cancer deaths worldwide; however, an incomplete understanding of how CS initiates preneoplastic changes in the normal airway hinders early diagnosis...
  73. ncbi Estimation and correlation of cigarette smoke exposure in Canadian smokers as determined by filter analysis and biomarkers of exposure
    André Morin
    Imperial Tobacco Canada Limited, Montreal, Canada
    Regul Toxicol Pharmacol 61:S3-12. 2011
    A clinical study conducted in Canada compared two methods of estimating exposure to cigarette smoke in 192 volunteer subjects: 43 smokers of 4-6 mg, 49 of 8-12 mg and 50 of 14-15 mg ISO tar yield cigarettes and 50 non-smokers...
  74. ncbi Wood smoke exposure, poverty and impaired lung function in Malawian adults
    D G Fullerton
    Malawi Liverpool Wellcome Clinical Research Laboratories, Universities of Malawi and Liverpool UK, Blantyre, Malawi
    Int J Tuberc Lung Dis 15:391-8. 2011
    ..Biomass smoke is associated with chronic obstructive pulmonary disease (COPD) in Asian and Central American countries, but there ..
  75. ncbi Reduced lung function due to biomass smoke exposure in young adults in rural Nepal
    Om P Kurmi
    Institute of Occupational and Environmental Medicine, University of Birmingham, Birmingham, UK
    Eur Respir J 41:25-30. 2013
    This study aimed to assess the effects of biomass smoke exposure on lung function in a Nepalese population, addressing some of the methodological issues seen in previous studies...
  76. pmc Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers
    Akshay Sood
    University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
    Am J Respir Crit Care Med 182:1098-104. 2010
    Wood smoke-associated chronic obstructive pulmonary disease (COPD) is common in women in developing countries but has not been adequately described in developed countries.
  77. ncbi Oxidative damage in human gingival fibroblasts exposed to cigarette smoke
    Graziano Colombo
    Department of Biology, Universita degli Studi di Milano, I 20133 Milan, Italy
    Free Radic Biol Med 52:1584-96. 2012
    Cigarette smoke, a complex mixture of over 7000 chemicals, contains many components capable of eliciting oxidative stress, which may induce smoking-related disorders, including oral cavity diseases...
  78. ncbi Immunotoxicology of arc welding fume: worker and experimental animal studies
    Patti C Zeidler-Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Immunotoxicol 9:411-25. 2012
    ..The objective of this report was to review both human and animal studies that have examined the effect of welding fume pulmonary exposure on local and systemic immune responses...
  79. pmc Genomic impact of cigarette smoke, with application to three smoking-related diseases
    M Talikka
    Philip Morris International R and D, Philip Morris Products S A, Neuchatel, Switzerland
    Crit Rev Toxicol 42:877-89. 2012
    There is considerable evidence that inhaled toxicants such as cigarette smoke can cause both irreversible changes to the genetic material (DNA mutations) and putatively reversible changes to the epigenetic landscape (changes in the DNA ..
  80. pmc Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages
    Mingzhen Li
    Section of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Arterioscler Thromb Vasc Biol 30:1818-24. 2010
    To investigate whether exposure of human monocytes/macrophages to tobacco smoke induces their release of membrane microvesicles (MVs) that carry tissue factor (TF) released from cells, whether smoke-induced MVs are procoagulant, and what ..
  81. pmc Cigarette smoke induced airway inflammation is independent of NF-κB signalling
    Joseph M D Rastrick
    Respiratory Pharmacology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 8:e54128. 2013
    COPD is an inflammatory lung disease largely associated with exposure to cigarette smoke (CS)...
  82. ncbi Tobacco smoke cooperates with interleukin-1beta to alter beta-catenin trafficking in vascular endothelium resulting in increased permeability and induction of cyclooxygenase-2 expression in vitro and in vivo
    Silvia S Barbieri
    Division of Hematology Medical Oncology, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
    FASEB J 21:1831-43. 2007
    ..We explored activation by exposure to tobacco smoke of two genes, beta-catenin and COX-2, that play key roles in inflammation and vascular remodeling events...
  83. pmc Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts
    Giorgia Volpi
    Department of Pharmacology, Chiesi Farmaceutici s p a, Parma, Italy
    Br J Pharmacol 163:649-61. 2011
    ..The aim of this study was to investigate whether acute exposure to cigarette smoke extract altered VEGF production in lung parenchymal cells.
  84. pmc Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress
    Nicolas Mercado
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    Biochem Biophys Res Commun 406:292-8. 2011
    ..Nrf2-regulated heme-oxygenase-1 (HO-1) expression in these cells, and this was confirmed in acute cigarette-smoke exposed mice in vivo...
  85. ncbi The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts
    C A Martey
    Chemistry Department, Shippensburg University, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 289:L391-9. 2005
    ..We recently demonstrated that human lung fibroblasts are activated by cigarette smoke to express COX-2 and prostaglandin E(2) (PGE(2))...
  86. ncbi Oxidative damage to DNA and repair induced by Norwegian wood smoke particles in human A549 and THP-1 cell lines
    Pernille Høgh Danielsen
    Institute of Public Health, Department of Environmental Health, University of Copenhagen, Øster Farimagsgade 5A, DK 1014 Copenhagen K, Denmark
    Mutat Res 674:116-22. 2009
    ..The aim of this study was to compare the genotoxicity of wood smoke particulate matter (WSPM), authentic traffic-generated particles, mineral PM and standard reference material (..
  87. ncbi Bone marrow cells repair cigarette smoke-induced emphysema in rats
    Jin Won Huh
    Dept of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan Univ School of Medicine, Suwon 440 746, South Korea
    Am J Physiol Lung Cell Mol Physiol 301:L255-66. 2011
    ..marrow cells (BMCs), mesenchymal stem cells (MSCs), and conditioned media of MSCs (MSC-CM) to repair cigarette smoke-induced emphysema...
  88. pmc Association of secondhand smoke exposures with DNA methylation in bladder carcinomas
    Charlotte S Wilhelm-Benartzi
    Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI, USA
    Cancer Causes Control 22:1205-13. 2011
    The association between secondhand smoke (SHS) exposure and bladder cancer is inconclusive...
  89. ncbi Exposure to wood smoke particles produces inflammation in healthy volunteers
    Andrew J Ghio
    The National Health and Environmental Effects Research Laboratory, US EPA, Research Triangle Park, North Carolina, USA
    Occup Environ Med 69:170-5. 2012
    Human exposure to wood smoke particles (WSP) impacts on human health through changes in indoor air quality, exposures from wild fires, burning of biomass and air pollution...
  90. pmc Sidestream tobacco smoke is a male germ cell mutagen
    Francesco Marchetti
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 108:12811-4. 2011
    ..However, little is known regarding the effects of second-hand smoke on the male germ line...
  91. pmc Mitochondrial localization and function of heme oxygenase-1 in cigarette smoke-induced cell death
    Dirk Jan Slebos
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, MUH 628NW, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Am J Respir Cell Mol Biol 36:409-17. 2007
    Cigarette smoke-induced apoptosis and necrosis contribute to the pathogenesis of chronic obstructive pulmonary disease...
  92. ncbi Effects of sidestream cigarette smoke exposure on baroreflex components in spontaneously hypertensive rats
    Vitor E Valenti
    Departamento de Medicina, Disciplina de Cardiologia, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil
    Int J Environ Health Res 20:431-7. 2010
    We evaluated short-term effects of sidestream cigarette smoke (SSCS) exposure on baroreflex function in spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) normotensive rats...
  93. pmc Cigarette smoke induces promoter methylation of single-stranded DNA-binding protein 2 in human esophageal squamous cell carcinoma
    Yiping Huang
    Department of Dermatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Int J Cancer 128:2261-73. 2011
    ..squamous cell carcinoma (ESCC) is the sixth most frequent cause of cancer death in the world, and cigarette smoke is a key factor in esophageal carcinogenesis...
  94. ncbi alpha-1-Antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
    Am J Respir Crit Care Med 168:199-207. 2003
    Serine elastase inhibitors have been proposed as a treatment for cigarette smoke-induced emphysema, but little is known about whether such agents actually are effective...
  95. pmc Inhibition of IFN-gamma-dependent antiviral airway epithelial defense by cigarette smoke
    Modestos A Modestou
    Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, Iowa 52242 1081, USA
    Respir Res 11:64. 2010
    Although individuals exposed to cigarette smoke are more susceptible to respiratory infection, the effects of cigarette smoke on lung defense are incompletely understood...
  96. pmc Antioxidant airway responses following experimental exposure to wood smoke in man
    Maria Sehlstedt
    Department of Public Health and Clinical Medicine, Division of Medicine, Umea University, Umea, Sweden
    Part Fibre Toxicol 7:21. 2010
    ..The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke PM under controlled conditions...
  97. pmc Menthol sensory qualities and smoking topography: a review of tobacco industry documents
    Valerie B Yerger
    Department of Social and Behavioral Sciences, University of California, San Francisco, Box 0612, San Francisco, CA 94143 0612, USA
    Tob Control 20:ii37-43. 2011
    ..To determine what the tobacco industry knew about the potential effects of menthol on smoking topography-how a person smokes a cigarette...
  98. ncbi The effect of tobacco ingredients on smoke chemistry. Part II: casing ingredients
    Richard R Baker
    British American Tobacco, Research and Development Centre, Regent s Park Road, Southampton SO15 8TL, UK
    Food Chem Toxicol 42:S39-52. 2004
    ..a study in which the effects of adding a range of ingredients to tobacco on the chemistry of cigarette mainstream smoke are assessed...
  99. pmc An animal model of cigarette smoke-induced in utero growth retardation
    Emily R Esposito
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, ULSD, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    Toxicology 246:193-202. 2008
    ..Over one million babies are exposed prenatally to cigarette smoke accounting for over 20% of the LBW incidence in the US...
  100. ncbi The transcriptome of Nrf2-/- mice provides evidence for impaired cell cycle progression in the development of cigarette smoke-induced emphysematous changes
    Stephan Gebel
    Philip Morris Research Laboratories GmbH, Philip Morris International Research and Development, Koln, Germany
    Toxicol Sci 115:238-52. 2010
    Cigarette smoke (CS) imposes a strong oxidative burden on exposed tissues resulting in a severely disturbed oxidant/antioxidant balance, which in the context of chronic exposure is assumed to be a key contributor to CS-related diseases...
  101. ncbi The effect of tobacco ingredients on smoke chemistry. Part I: Flavourings and additives
    Richard R Baker
    British American Tobacco, Research and Development Centre, Regent s Park Road, Southampton SO15 8TL, UK
    Food Chem Toxicol 42:S3-37. 2004
    ..effects of 450 tobacco ingredients added to tobacco on the forty-four "Hoffmann analytes" in mainstream cigarette smoke have been determined...

Research Grants74

  1. Pilot and definitive studies to evaluate Insertional Mutagenesis
    LU TAYLOR; Fiscal Year: 2012
    ..goal of this project is to develop a panel of biologic response markers for environmental agents (ozone, cigarette smoke, endotoxin, and allergen) that are known to perturb biologic systems resulting in changes in the airway that lead ..
  2. Studies to Evaluate the Toxicological Potential of Test Articles
    LU TAYLOR; Fiscal Year: 2010
    ..goal of this project is to develop a panel of biologic response markers for environmental agents (ozone, cigarette smoke, endotoxin, and allergen) that are known to perturb biologic systems resulting in changes in the airway that lead ..
  3. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..We will also collect information on health history, clinical characteristics, tobacco smoke exposure, diet and time-activity patterns...
  4. Lung Lysyl Oxidase Regulation by Metal Ion Homeostasis
    Wande Li; Fiscal Year: 2013
    ..exposure of humans to cadmium (Cd), a heavy metal, either from occupational contamination or from cigarette smoke, induces emphysema and lung cancers...
  5. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): At least 20% of pregnant women smoke, and their offspring have a higher than normal incidence of impaired cardiac function, autonomic nervous system disorders, sleep disorders, delayed speech and ..
  6. Nanoparticle Coupled Antioxidants for Respiratory Illness in Veterans
    RODNEY JON SCHLOSSER; Fiscal Year: 2013
    ..of environmental exposures that likely contribute to these inflammatory respiratory conditions, to include tobacco smoke and diesel exhaust. Nearly half of OEF/OIF Veterans started or re-started smoking during deployment...
  7. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-Lead
    CYNTHIA T MCEVOY; Fiscal Year: 2013
    ..Key genetic polymorphisms shown to increase sensitivity to in utero smoke exposure will also be measured...
  8. Tobacco Control Research Branch Scientific and Technical Services Support
    KOURTNEY MARSHALL; Fiscal Year: 2009
    ..growing practices, particularly those dealing with breeding and genetics which change the tobacco and tobacco smoke constituents; 10) The epidemiologic, clinical or experimental nature of the smoking relationship with specific ..
  9. Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    Arthur Brody; Fiscal Year: 2013
    ..S. population (~46 million U.S. adults). Of these smokers, approximately 33% smoke menthols, meaning that roughly 9% of all Veterans smoke menthol cigarettes...
  10. Ubiquitous pollutant acrolein inhibits IFN?? antiviral signaling: relevance to HC
    Swati Joshi-Barve; Fiscal Year: 2013
    ..Moreover, acrolein is a major component of cigarette smoke and recent studies suggest that smokers with chronic hepatitis C have a lower response rate to IFN1 compared to ..
  11. Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism
    Reen Wu; Fiscal Year: 2013
    ..Furthermore, we showed both all-trans-retinoic acid and smoke are able to alter the methylation status of MUC5AC CpG islands and that this status is inversely related MUC5AC ..
  12. MOLECULAR MECHANISMS OF COMPLEX MIXTURE TOXICITY
    Alvaro Puga; Fiscal Year: 2013
    ..in numbers ranging from a few, such as in many occupational exposures, to several thousand, as in cigarette smoke. Frequently, these mixtures include a combination of carcinogenic metals and polycyclic aromatic hydrocarbons (PAH)..
  13. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Cigarette smoke-related lung diseases is one of the most common causes of disability and death among veterans...
  14. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ..Interestingly, an elevated level of Fra-1 expression has been reported in the lungs of cigarette smoke-exposed mice that have developed emphysema...
  15. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013
    ..Endotoxin is almost universally present, and has been found at high levels in tobacco smoke, homes burning biomass fuel, in the context of various occupations especially cotton textile work, and more ..
  16. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2013
    ..aging (accelerated decline in lung function) and chronic inflammation of the lungs due to inhaled cigarette smoke-derived oxidants and free radicals which are implicated in aging, senescence, cancer and inflammatory processes...
  17. Resuscitation of smoke inhalation and burn injury with a thioredoxin mimetic
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Smoke inhalation and burn injury (SIBI) induces acute lung injury (ALI) via the generation of toxic free radical and oxidant species that, in turn, trigger DNA single strand breaks (SSB) throughout ..
  18. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..Collectively, these complementary aims will provide new insights into the pathogenesis of smoke induce emphysema with the long term goals to find new and effective therapies for these conditions...
  19. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2012
    ..specific nitrosamine 4-(methylnitrosamino)-1-(3- pyridyl)-1-butanone (NNK) is a major lung carcinogen in tobacco smoke, (2) that 2-phenethyl isothiocyanate (PEITC) is a potent inhibitor of NNK-induced lung carcinogenesis in rats and ..
  20. The Effects of PP2A on TNF Signaling and Smoke-Induced Lung Injury
    Robert F Foronjy; Fiscal Year: 2013
    ..by applicant): To date, there are no effective therapies that can counteract the damaging effects of cigarette smoke exposure in the lung...
  21. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-DCC
    Cynthia D Morris; Fiscal Year: 2013
    ..Key genetic polymorphisms shown to increase sensitivity to in utero smoke exposure will also be measured...
  22. Pulmonary effects of biomass fuel indoor PM from rural India
    Shyam Biswal; Fiscal Year: 2013
    Project Summary About 3 billion people, half the worldwide population, are exposed to smoke from biomass fuel compared with 1 billion people who smoke tobacco, which suggests that exposure to biomass smoke might be the biggest risk ..
  23. EEG Synchrony, perinatal risk and outcome: analysis of CHIME data
    PHILIP GEORGE GRIEVE; Fiscal Year: 2010
    ..These include: 1) prenatal factors such as fetal exposure to alcohol and tobacco smoke, drugs of use and abuse and, in some cases, mode of delivery;2) intra-partum factors such as presence and duration ..
  24. PREVENTION OF QUINONE TOXICITY AND MUTAGENICITY
    ANIL KUMAR JAISWAL; Fiscal Year: 2013
    ..Epidemiological studies have shown an association between human NQO1P187S mutation and cigarette smoke related bladder cancer...
  25. Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of Pregnan
    Shao Lin; Fiscal Year: 2013
    ..certain chronic diseases, those taking heat-sensitizing medications, those of low socioeconomic status, those who smoke or drink alcohol, or those with outdoor occupations are more vulnerable to extreme weather conditions...
  26. Inducible Macrophage Specific Gene Expression in Diseases
    JEANINE M D apos ARMIENTO; Fiscal Year: 2010
    ..and specificity and inducibility of Cre expression will be assessed in three models of lung injury (cigarette smoke exposure, asthma, and acute lung injury)...
  27. Impact of smoking on immune response and arthritis in humanized mice
    Veena Taneja; Fiscal Year: 2011
    ..mice showed that DQ8 mice develop arthritis with earlier onset and increased severity in mice exposed to cigarette smoke compared to controls, although this effect was not observed in DR4 mice...
  28. Effect of Neonatal Hyperoxia on Alveolar Development and Infection
    MICHAEL A O'REILLY; Fiscal Year: 2012
    ..oxygen at birth are more likely to have viral infections, asthma, increased sensitivity to second hand cigarette smoke, and more out-of-school sick days than children who were not exposed to oxygen...
  29. High Throughput Methods to Measure Disparities in Childhood Exposure to Tobacco
    Sharon E Murphy; Fiscal Year: 2010
    ..are involuntarily exposed to tobacco both in utero through maternal smoking and during childhood from secondhand smoke (SHS)...
  30. Host Defense Mechanisms in Polyaromatic Hydrogen Carcinogenesis
    Craig A Elmets; Fiscal Year: 2013
    ..hydrocarbons are ubiquitous environmental compounds that are the major carcinogenic moiety in cigarette smoke and were present in the burning oilfield emissions in the Persian Gulf War...
  31. Iodine Nutrition and Thyroid Disease During Pregnancy and Lactation
    ANGELA MEI TIN LEUNG; Fiscal Year: 2013
    ..In addition, environmental exposures to perchlorate and cigarette smoke (which is metabolized to thiocyanate) decrease iodine uptake into the lactating breast, thereby further impairing ..
  32. The RAGE of COPD
    John R Hoidal; Fiscal Year: 2013
    ..will study the expression of RAGE and its ligands during the development of emphysema using a model of cigarette smoke exposure to mice...
  33. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    ..determined models for established emphysema and (3) Test the in vivo efficacy of BB3 in established cigarette smoke-induced emphysema in the mouse...
  34. Neprilysin and Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms
    EDWARD CHARLES DEMPSEY; Fiscal Year: 2013
    ..Many factors, including cigarette smoke (CS), oxidant stress, inflammation and eventually hypoxia, contribute to the observed vascular dysfunction and ..
  35. Endothelial Progenitor Cells and Particulate Air Pollution
    Arden Pope; Fiscal Year: 2013
    ..which are generated directly from the combustion of fossil fuels and are found in automobile exhaust, wood or coal smoke and industrial emission from smelters, paper or steel mills or cement plants...
  36. Exposure and biological response biomarkers of cigarette smoke
    IAN ALEXANDER BLAIR; Fiscal Year: 2010
    Exposure and biological response biomarkers of cigarette smoke. Exposure to tobacco smoke (mainstream and environmental) is a leading cause of death in the US...
  37. Role of Id1 in NSCLC Progression and Metastasis
    Srikumar P Chellappan; Fiscal Year: 2013
    ..Many tobacco-specific carcinogens present in cigarette smoke cause DNA damage, leading to the mutation of vital genes like Ras, p53 and Rb...
  38. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    MICHAEL THOMAS FASULLO; Fiscal Year: 2010
    ..infection with hepatitis B (HBV) and C viruses (HCV), while additional risk factors include exposure to tobacco smoke. Cytochrome P450 genes, such as CYP1A1, CYP1A2, CYP3A4, and CYP3A5 encode proteins that activate potent liver ..
  39. Alcoholic Liver Dysfunction Potentiation by Hyperlipidemia and Cigarette Smoke
    SHANNON MARIE BAILEY; Fiscal Year: 2013
    ..widespread hyperlipidemia and 2) pervasive exposure to airborne environmental toxicants like second-hand cigarette smoke, a.k.a. environmental tobacco smoke (ETS)...
  40. Resolving the role of nicotine-mediated phosphorylation on pancreatic fibrosis
    Joao A Paulo; Fiscal Year: 2013
    ..In addition, nicotine, the major toxic component of cigarette smoke is implicated in fibrosis in various cell types...
  41. Cancer induction in the ovary by an environmental pollutant, dibenzo[a,l]pyrene
    Kun Ming Chen; Fiscal Year: 2013
    ..ovarian carcinogenesis in mice treated with dibenzo[a,l]pyrene (DB[a,l]P);an environmental pollutant and a tobacco smoke constituent...
  42. STRAW+10: Addressing the Unfinished Agenda of Staging Reproductive Aging - RESUBM
    Sioban D Harlow; Fiscal Year: 2011
    ..count, anti-mullerian hormone and inhibin-B;to assess how to include women with higher body-mass-index and who smoke in staging algorithms;to provide recommendations regarding staging of women following gynecological surgery, ..
  43. Integrated PTSD and Smoking Treatment
    Mark B Powers; Fiscal Year: 2013
    ..5% in persons with no psychiatric disorder.8 Smokers with PTSD are more likely to be dependent,4 smoke heavily (>25 cigarettes per day),2 experience more severe withdrawal symptoms, and relapse following a quit ..
  44. Brain Nicotine Receptor Density &Response to Nicotine Patch
    Arthur Brody; Fiscal Year: 2013
    ..8% of American adults continue to smoke. While most smokers endorse a desire to quit, very few (<5%) will actually quit in a given year without ..
  45. Mechanisms of oxidant-induced chronic bronchitis
    ROSANNA C MALBRAN FORTEZA; Fiscal Year: 2012
    ..likely provide new tools for the prevention or/and treatment of chronic airway diseases, particularly cigarette smoke- induced chronic bronchitis. PUBLIC HEALTH RELEVANCE...
  46. Cigarette Smoke-derived Electrophilic Aldehydes and Airway Inflammation
    Albert van Der Vliet; Fiscal Year: 2013
    ..The adverse health effects of cigarette smoke (CS) are largely related to its immuno-suppressive properties leading to impaired innate immune responses, host ..
  47. Development and Regulation of Cholinergic Synapses
    Andres Villu Maricq; Fiscal Year: 2013
    ..of the brain;nicotine can partly mimic the action of acetylcholine and is the active ingredient found in cigarette smoke that leads to addiction...
  48. Prevention of EtOH-induced promotion of hepatocarcinogenesis by genistein/soy
    Martin J J Ronis; Fiscal Year: 2013
    ..exposure to dietary and environmental carcinogens such as nitrosamines found in alcoholic beverages and cigarette smoke or via hepatitis infection...
  49. Diesel, Allergens and Gene Interaction and Child Atopy
    Grace LeMasters; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: It is widely accepted that exposure to environmental tobacco smoke causes development and exacerbation of respiratory disorders, including asthma...
  50. Abnormality in Gene Expression of Key Mediators of Vitamin A Action in COPD
    Salil K Das; Fiscal Year: 2010
    ..We have reported earlier that cigarette smoke exposure in our guinea pig model caused an accumulation of retinol and a decrease in RA in lung, suggesting an ..
  51. Developing Novel Dual CRF-R1/Orexin-1 Receptor Antagonists for Tobacco Dependence
    Belew Mekonnen; Fiscal Year: 2011
    ..of nicotine dependence, still approximately 21% of the adult population in the United States continues to smoke, and the increase in disease prevalence and health care expenditure has been positively correlated with smoking...
  52. CFTR Biogenesis and Function in Epithelia
    Zsuzsa Bebok; Fiscal Year: 2012
    ..Environmental stress such as cigarette smoke causes endoplasmic reticulum stress and activates the unfolded protein response, and the effects of this cellular ..
  53. PPAR gamma Agonists for Lung Cancer Chemoprevention
    Robert Keith; Fiscal Year: 2013
    ..are chemoprotected in several distinct murine adenocarcinoma models (including both chemical and tobacco-smoke exposure)...
  54. Developmental defects in serotonin neurons and the response to O2 and CO2
    George B Richerson; Fiscal Year: 2011
    ..We will also examine the effect on wild-type and mutant mice of prenatal exposure to cigarette smoke. We will then use the perfused brain preparation and brain slices to determine whether there is an alteration of ..
  55. (INTRODUCTION) MECHANISMS OF ACCLIMATIZATION: FETUS AND ADULT
    Lawrence D Longo; Fiscal Year: 2013
    ..they relate to responses to prolonged hypoxia as occurs in women who live at high altitude, as well as those who smoke or are anemic, who have heart or lung disease, or with "placental insufficiency...
  56. Role of interleukin-17 and iNKT cells in COPD
    ABDALA EL KHAL; Fiscal Year: 2010
    ..COPD is usually caused by tobacco smoke that disrupts the epithelial barrier and induces a migration of different cell type such as neutrophils, ..
  57. Modulation of Genes Responsible for Cilia Length by Exposure to Cigarette Smoke
    Ann E Tilley; Fiscal Year: 2013
    ..Even before the development of COPD, individuals who smoke may demonstrate a reduction in mucociliary clearance...
  58. Integrated Treatment for Smoking Cessation &Anxiety in People with HIV
    Michael J Zvolensky; Fiscal Year: 2013
    ..S.), contributing to over 440,000 deaths each year. Still, over 40 million adults in the U.S. currently smoke despite well-established links to morbidity and mortality...
  59. The Unfolded Protein Response in Human Airway and Alveolar Epithelial Cells
    Salim Merali; Fiscal Year: 2010
    ..We have not studied the in situ response of specific lung cell types to cigarette smoke exposure...
  60. Cookstove Replacement for Prevention of ARI and Low Birthweight in Nepal
    JAMES MACK TIELSCH; Fiscal Year: 2012
    ..birth weight, we have designed a community-based randomized trial to determine if reductions in household indoor smoke exposure can reduce the incidence and duration of acute lower respiratory infections in children <36 months of ..
  61. Induction of Nerve Growth Factor by Nicotine Leads to Airway Dysfunction
    CHERRY P WONGTRAKOOL; Fiscal Year: 2013
    ..Tobacco smoke exposure can promote airway hyperresponsiveness (AHR), a characteristic feature of asthma defined as airway ..
  62. A+ Head Start Intervention for Smoke Free Homes
    Cynthia S Rand; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Environmental tobacco smoke (ETS) exposure has been identified as a significant threat to children's respiratory health and has been clearly linked to increased risk of asthma, bronchitis, ..
  63. Metals in exhaled breath condensate as COPD biomarkers
    Antonio Mutti; Fiscal Year: 2005
    ..identify and validate biomarkers of exposure and susceptibility to toxic metals, known to be contained in tobacco smoke, and probably playing a fundamental etiologic role in the pathogenetic path leading to COPD...
  64. Preventing Postpartum Smoking Relapse: A C-SHIP Based Text Messaging Intervention
    Suzanne M Miller; Fiscal Year: 2010
    ..In this country, an estimated 40% of women who smoke quit during their pregnancy...
  65. Using Ecolog. Momentary Assess. To Examine Pain & Smoking In Head & Neck Cancer P
    CHO YAN LAM; Fiscal Year: 2010
    ..However, on learning about their cancer diagnosis, many patients who smoke continue to use tobacco. Even among patients who quit, many fail to maintain long-term abstinence...
  66. Clinical Response to Biomarker Documentation of Child Secondhand Smoke Exposure
    ANNE JOSEPH; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Smoking and secondhand smoke (SHS) are responsible for nearly a half-million preventable deaths in the United States every year...
  67. PARS inhibitor therapy of smoke inhalation injury
    Prakash Jagtap; Fiscal Year: 2001
    b>Smoke inhalation and burn injury induce an inflammatory pneumonitis that may progress to severe respiratory failure. Current treatment options are limited to supportive measures...
  68. PARS inhibitor therapy for smoke inhalation
    Andrew Salzman; Fiscal Year: 2004
    b>Smoke inhalation is a major co-morbid factor in thermal injury. Therapy of smoke inhalation is supportive -there are no specific countermeasures to protect the lung from injury...
  69. The Impact of Smoke-Free Policy on Quitline Utilization and Smoking Outcomes
    ANITA FAY FERNANDER; Fiscal Year: 2010
    ..The CDC, as part of its Comprehensive Tobacco Control Initiative, has suggested, in addition to enacting smoke-free policies, every state implement a publicly-accessible telephone QuitLine for tobacco users who want to quit...
  70. BIOLOGIC ACTIVITY OF BETA-CAROTENE METABOLITES
    Robert Russell; Fiscal Year: 2005
    ..A mechanism to explain the instability of the beta-carotene molecule is that exposure of lung cells to smoke results in increased lung cell oxidative stress, thereby causing decreased tissue levels of other important ..
  71. Analysis of Somatic Mutations in Cancer of the Kidney
    WAYNE VEDECKIS; Fiscal Year: 2005
    ..cancer and renal pelvic carcinoma it has been established that G:C->A:T transitions in p53 result from tobacco smoke carcinogens), and because we have access to DNA from 1,141 newly diagnosed renal cell carcinoma cases in the INCO ..
  72. EFFECTS OF COCAINE ON PLACENTAL GROWTH FACTORS
    Kathleen Shiverick; Fiscal Year: 1993
    ..Our recent studies with human and rat placenta indicate that exposure to cigarette smoke, and isolated constituents of cigarette smoke, are associated with selective alterations in receptors for growth ..
  73. Nicotine Replacement Treatment for Pregnant Smokers
    Cheryl Oncken; Fiscal Year: 2006
    ..Unfortunately, the majority of women who smoke prior to pregnancy continue to smoke during pregnancy...
  74. MECHANISM OF CIGARETTE SMOKE-INDUCED IMMUNOSUPPRESSION
    Mohan Sopori; Fiscal Year: 2003
    Epidemiological studies suggest that chronic inhalation of cigarette smoke (SM) is associated with increased risk of cancer, heart disease, respiratory infections, and other infections including AIDS...