air pollution

Summary

Top Publications

  1. ncbi Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
    C Arden Pope
    Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
    Circulation 109:71-7. 2004
  2. pmc Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases
    Francesca Dominici
    Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    JAMA 295:1127-34. 2006
  3. ncbi Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)
    Ole Raaschou-Nielsen
    Danish Cancer Society Research Center, Copenhagen, Denmark
    Lancet Oncol 14:813-22. 2013
  4. pmc Air pollution and incidence of hypertension and diabetes mellitus in black women living in Los Angeles
    Patricia F Coogan
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Ave, Boston, MA 02215, USA
    Circulation 125:767-72. 2012
  5. pmc Clearing the air: a review of the effects of particulate matter air pollution on human health
    Jonathan O Anderson
    Department of Medical Education, Orlando Health Emergency Medicine, Orlando, FL 32806, USA
    J Med Toxicol 8:166-75. 2012
  6. pmc Exposure measurement error in time-series studies of air pollution: concepts and consequences
    S L Zeger
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 108:419-26. 2000
  7. ncbi Association of particulate air pollution with daily mortality: the China Air Pollution and Health Effects Study
    Renjie Chen
    School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China
    Am J Epidemiol 175:1173-81. 2012
  8. pmc Long-term exposure to air pollution and cardiorespiratory disease in the California teachers study cohort
    Michael J Lipsett
    California Department of Public Health, Richmond, CA 94804, USA
    Am J Respir Crit Care Med 184:828-35. 2011
  9. ncbi The asthma epidemic
    Waltraud Eder
    University Children s Hospital, Munich, Germany
    N Engl J Med 355:2226-35. 2006
  10. ncbi Main air pollutants and myocardial infarction: a systematic review and meta-analysis
    Hazrije Mustafic
    Paris Cardiovascular Research Center, University Paris Descartes, INSERM Unit 970, Paris, France
    JAMA 307:713-21. 2012

Detail Information

Publications390 found, 100 shown here

  1. ncbi Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease
    C Arden Pope
    Brigham Young University, 130 FOB, Provo, UT 84602 2363, USA
    Circulation 109:71-7. 2004
    Epidemiologic studies have linked long-term exposure to fine particulate matter air pollution (PM) to broad cause-of-death mortality...
  2. pmc Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases
    Francesca Dominici
    Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    JAMA 295:1127-34. 2006
    ..5 microm in aerodynamic diameter [PM2.5]) is limited. Results from the new national monitoring network for PM2.5 make possible systematic research on health risks at national and regional scales...
  3. ncbi Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)
    Ole Raaschou-Nielsen
    Danish Cancer Society Research Center, Copenhagen, Denmark
    Lancet Oncol 14:813-22. 2013
    Ambient air pollution is suspected to cause lung cancer. We aimed to assess the association between long-term exposure to ambient air pollution and lung cancer incidence in European populations.
  4. pmc Air pollution and incidence of hypertension and diabetes mellitus in black women living in Los Angeles
    Patricia F Coogan
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Ave, Boston, MA 02215, USA
    Circulation 125:767-72. 2012
    ..Preliminary epidemiological and clinical evidence suggests that air pollution may contribute to the development of hypertension and type 2 diabetes mellitus.
  5. pmc Clearing the air: a review of the effects of particulate matter air pollution on human health
    Jonathan O Anderson
    Department of Medical Education, Orlando Health Emergency Medicine, Orlando, FL 32806, USA
    J Med Toxicol 8:166-75. 2012
    The World Health Organization estimates that particulate matter (PM) air pollution contributes to approximately 800,000 premature deaths each year, ranking it the 13th leading cause of mortality worldwide...
  6. pmc Exposure measurement error in time-series studies of air pollution: concepts and consequences
    S L Zeger
    Johns Hopkins University, School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 108:419-26. 2000
    ..In this paper, we address measurement error in observational studies of air pollution and health...
  7. ncbi Association of particulate air pollution with daily mortality: the China Air Pollution and Health Effects Study
    Renjie Chen
    School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai, China
    Am J Epidemiol 175:1173-81. 2012
    ..Conclusively, this largest epidemiologic study of particulate air pollution in China suggests that short-term exposure to PM(10) is associated with increased mortality risk.
  8. pmc Long-term exposure to air pollution and cardiorespiratory disease in the California teachers study cohort
    Michael J Lipsett
    California Department of Public Health, Richmond, CA 94804, USA
    Am J Respir Crit Care Med 184:828-35. 2011
    Several studies have linked long-term exposure to particulate air pollution with increased cardiopulmonary mortality; only two have also examined incident circulatory disease.
  9. ncbi The asthma epidemic
    Waltraud Eder
    University Children s Hospital, Munich, Germany
    N Engl J Med 355:2226-35. 2006
  10. ncbi Main air pollutants and myocardial infarction: a systematic review and meta-analysis
    Hazrije Mustafic
    Paris Cardiovascular Research Center, University Paris Descartes, INSERM Unit 970, Paris, France
    JAMA 307:713-21. 2012
    Short-term exposure to high levels of air pollution may trigger myocardial infarction (MI), but this association remains unclear.
  11. ncbi Case-crossover analyses of air pollution exposure data: referent selection strategies and their implications for bias
    Holly Janes
    Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
    Epidemiology 16:717-26. 2005
    The case-crossover design has been widely used to study the association between short-term air pollution exposure and the risk of an acute adverse health event...
  12. pmc Global association of air pollution and heart failure: a systematic review and meta-analysis
    Anoop S V Shah
    BHF University Centre for Cardiovascular Science, University of Edinburgh, UK
    Lancet 382:1039-48. 2013
    Acute exposure to air pollution has been linked to myocardial infarction, but its effect on heart failure is uncertain...
  13. pmc Surrounding greenness and exposure to air pollution during pregnancy: an analysis of personal monitoring data
    Payam Dadvand
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain
    Environ Health Perspect 120:1286-90. 2012
    ..Despite the suggestions of air pollution-related health benefits of green spaces, there is no available evidence on the impact of greenness on personal ..
  14. pmc Long-term exposure to traffic-related air pollution and the risk of coronary heart disease hospitalization and mortality
    Wen Qi Gan
    School of Environmental Health, University of British Columbia, Vancouver, British Columbia, Canada
    Environ Health Perspect 119:501-7. 2011
    ..Epidemiologic studies have demonstrated that exposure to road traffic is associated with adverse cardiovascular outcomes...
  15. pmc Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis
    Martine Vrijheid
    Center for Research in Environmental Epidemiology, Barcelona, Spain
    Environ Health Perspect 119:598-606. 2011
    We systematically reviewed epidemiologic studies on ambient air pollution and congenital anomalies and conducted meta-analyses for a number of air pollutant-anomaly combinations.
  16. pmc Ambient air pollution and the progression of atherosclerosis in adults
    Nino Kunzli
    Swiss Tropical and Public Health Institute Swiss TPH, Basel, Switzerland University of Basel, Basel, Switzerland corrected
    PLoS ONE 5:e9096. 2010
    Cross-sectional studies suggest an association between exposure to ambient air pollution and atherosclerosis...
  17. pmc Meeting report: atmospheric pollution and human reproduction
    Remy Slama
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Environ Health Perspect 116:791-8. 2008
    ..There is a growing body of epidemiologic literature reporting associations between atmospheric pollutants and reproductive outcomes, particularly birth weight and gestational duration...
  18. pmc Comparing exposure assessment methods for traffic-related air pollution in an adverse pregnancy outcome study
    Jun Wu
    Program in Public Health and Department of Epidemiology, Anteater Instruction and Research Office, University of California, Irvine, CA 92697 3957, USA
    Environ Res 111:685-92. 2011
    Previous studies reported adverse impacts of traffic-related air pollution exposure on pregnancy outcomes...
  19. ncbi Association of long-term exposure to community noise and traffic-related air pollution with coronary heart disease mortality
    Wen Qi Gan
    School of Population and Public Health, The University of British Columbia, Vancouver, Canada
    Am J Epidemiol 175:898-906. 2012
    In metropolitan areas, road traffic is a major contributor to ambient air pollution and the dominant source of community noise...
  20. ncbi Genomics and the respiratory effects of air pollution exposure
    John W Holloway
    Human Development and Health, University of Southampton, Southampton, UK
    Respirology 17:590-600. 2012
    ..SNP have detected SNP associated with respiratory phenotypes; however, to date, only candidate gene studies of air pollution exposure have been performed...
  21. ncbi Adverse cardiovascular effects of air pollution
    Nicholas L Mills
    Centre for Cardiovascular Science, University of Edinburgh, UK
    Nat Clin Pract Cardiovasc Med 6:36-44. 2009
    b>Air pollution is increasingly recognized as an important and modifiable determinant of cardiovascular disease in urban communities...
  22. pmc Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort
    Marie Abele Bind
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 23:332-40. 2012
    Previous studies suggest that air pollution is related to thrombosis, inflammation, and endothelial dysfunction. Mechanisms and sources of susceptibility are still unclear...
  23. pmc Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity
    Qinghua Sun
    Wolfe Professor of Medicine and Radiology, Davis Heart and Lung Research Institute, Room 110, 473 W 12th Ave, Columbus, OH 43210 1252, USA
    Circulation 119:538-46. 2009
    ..We hypothesized that exposure to ambient fine particulate matter (<2.5 mum; PM(2.5)) exaggerates diet-induced insulin resistance, adipose inflammation, and visceral adiposity...
  24. pmc Traffic-related air pollution and cognitive function in a cohort of older men
    Melinda C Power
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 119:682-7. 2011
    ..Traffic-related particles induce oxidative stress and may exert adverse effects on central nervous system function, which could manifest as cognitive impairment...
  25. ncbi Long-term exposure to air pollution and incidence of cardiovascular events in women
    Kristin A Miller
    Department of Epidemiology, University of Washington, Seattle, USA
    N Engl J Med 356:447-58. 2007
    Fine particulate air pollution has been linked to cardiovascular disease, but previous studies have assessed only mortality and differences in exposure between cities...
  26. pmc Fine-particulate air pollution and life expectancy in the United States
    C Arden Pope
    Department of Economics, Brigham Young University, Provo, UT 84602 2363, USA
    N Engl J Med 360:376-86. 2009
    Exposure to fine-particulate air pollution has been associated with increased morbidity and mortality, suggesting that sustained reductions in pollution exposure should result in improved life expectancy...
  27. pmc Respiratory health effects of air pollution: update on biomass smoke and traffic pollution
    Robert J Laumbach
    Environmental and Occupational Health Sciences Institute, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School and Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    J Allergy Clin Immunol 129:3-11; quiz 12-3. 2012
    Mounting evidence suggests that air pollution contributes to the large global burden of respiratory and allergic diseases, including asthma, chronic obstructive pulmonary disease, pneumonia, and possibly tuberculosis...
  28. pmc Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
    C Arden Pope
    Department of Economics, Brigham Young University, 142 FOB, Provo, UT 84602, USA
    JAMA 287:1132-41. 2002
    Associations have been found between day-to-day particulate air pollution and increased risk of various adverse health outcomes, including cardiopulmonary mortality...
  29. ncbi Long-term exposure to outdoor air pollution and incidence of cardiovascular diseases
    Richard W Atkinson
    Division of Population Health Sciences and Education and MRC HPA Centre for Environment and Health, St George s, University of London, London, United Kingdom
    Epidemiology 24:44-53. 2013
    ..age 40 to 89 years registered with 205 English general practices in 2003, we investigated relationships between ambient outdoor air pollution and incident myocardial infarction, stroke, arrhythmia, and heart failure over a 5-year period.
  30. pmc Practical advancement of multipollutant scientific and risk assessment approaches for ambient air pollution
    Douglas O Johns
    National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 120:1238-42. 2012
    ....
  31. ncbi Aircraft noise, air pollution, and mortality from myocardial infarction
    Anke Huss
    Institute of Social and Preventive Medicine ISPM, University of Bern, Bern, Switzerland
    Epidemiology 21:829-36. 2010
    Myocardial infarction has been associated with both transportation noise and air pollution. We examined residential exposure to aircraft noise and mortality from myocardial infarction, taking air pollution into account.
  32. pmc Traffic-related air pollution, particulate matter, and autism
    Heather E Volk
    Department of Preventive Medicine, Keck School of Medicine, Zilkha Neurogenetic Institute, Children s Hospital Los Angeles, University of Southern California, Los Angeles, CA 90089, USA
    JAMA Psychiatry 70:71-7. 2013
    ..Examination of hazardous pollutants has suggested the importance of air toxics in the etiology of autism, yet little research has examined its association with local levels of air pollution using residence-specific exposure assignments.
  33. ncbi Traffic-related air pollution and development of allergic sensitization in children during the first 8 years of life
    Olena Gruzieva
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    J Allergy Clin Immunol 129:240-6. 2012
    The role of exposure to air pollution in the development of allergic sensitization remains unclear.
  34. pmc Protecting human health from air pollution: shifting from a single-pollutant to a multipollutant approach
    Francesca Dominici
    Department of Biostatistics, Harvard University School of Public Health, Boston, MA 02115, USA
    Epidemiology 21:187-94. 2010
    To date, the assessment of public health consequences of air pollution has largely focused on a single-pollutant approach aimed at estimating the increased risk of adverse health outcomes associated with the exposure to a single air ..
  35. pmc Exposure assessment for estimation of the global burden of disease attributable to outdoor air pollution
    Michael Brauer
    School of Population and Public Health, The University of British Columbia, 2206 East Mall, Vancouver, British Columbia V6T1Z3, Canada
    Environ Sci Technol 46:652-60. 2012
    Ambient air pollution is associated with numerous adverse health impacts. Previous assessments of global attributable disease burden have been limited to urban areas or by coarse spatial resolution of concentration estimates...
  36. pmc Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans
    Robert D Brook
    University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Hypertension 54:659-67. 2009
    Fine particulate matter air pollution plus ozone impairs vascular function and raises diastolic blood pressure. We aimed to determine the mechanism and air pollutant responsible...
  37. pmc An association between long-term exposure to ambient air pollution and mortality from lung cancer and respiratory diseases in Japan
    Kota Katanoda
    Cancer Information Services and Surveillance Division, Center for Cancer Control and Information Services, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Epidemiol 21:132-43. 2011
    Evidence for a link between long-term exposure to air pollution and lung cancer is limited to Western populations. In this prospective cohort study, we examined this association in a Japanese population.
  38. pmc Air pollution: mechanisms of neuroinflammation and CNS disease
    Michelle L Block
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, VA 23298, USA
    Trends Neurosci 32:506-16. 2009
    b>Air pollution has been implicated as a chronic source of neuroinflammation and reactive oxygen species (ROS) that produce neuropathology and central nervous system (CNS) disease...
  39. ncbi Health effects of fine particulate air pollution: lines that connect
    C Arden Pope
    Department of Economics, Brigham Young University, Provo, UT 84602 2363, USA
    J Air Waste Manag Assoc 56:709-42. 2006
    ..evaluation of the research findings provides persuasive evidence that exposure to fine particulate air pollution has adverse effects on cardiopulmonaryhealth...
  40. pmc Long-term ozone exposure and mortality
    Michael Jerrett
    Division of Environmental Health Sciences, School of Public Health, University of California, 710 University Hall, Berkeley, CA 94720, USA
    N Engl J Med 360:1085-95. 2009
    ..elevations in tropospheric ozone to adverse health outcomes, the effect of long-term exposure to ozone on air pollution-related mortality remains uncertain...
  41. ncbi Near-roadway air quality: synthesizing the findings from real-world data
    Alex A Karner
    U C Davis Caltrans Air Quality Project, Department of Civil and Environmental Engineering, University of California, Davis, California 95616, USA
    Environ Sci Technol 44:5334-44. 2010
    Despite increasing regulatory attention and literature linking roadside air pollution to health outcomes, studies on near roadway air quality have not yet been well synthesized...
  42. ncbi Air pollution exposure assessment methods utilized in epidemiological studies
    Bin Zou
    Central South University, School of Info Physics and Geomatics Engineering, Changsha, Hunan 410086, China
    J Environ Monit 11:475-90. 2009
    The assessment of personal exposure to air pollution is a critical component of epidemiological studies associating air pollution and health effects...
  43. ncbi Urban particulate matter air pollution is associated with subclinical atherosclerosis: results from the HNR (Heinz Nixdorf Recall) study
    Marcus Bauer
    Department of Cardiology, West German Heart Center Essen, University Hospital, University of Duisburg Essen, Essen, Germany
    J Am Coll Cardiol 56:1803-8. 2010
    ..The aim of this study was to investigate the association of long-term residential exposure to fine particles with carotid intima-media thickness (CIMT)...
  44. pmc Fine particulate air pollution and its components in association with cause-specific emergency admissions
    Antonella Zanobetti
    Department of Environmental Health, School of Public Health, Harvard University, Boston, MA, USA
    Environ Health 8:58. 2009
    ..We explored whether the association between cause-specific hospital admissions and PM(2.5) was modified by PM(2.5) chemical composition...
  45. pmc Particulate matter-induced health effects: who is susceptible?
    Jason D Sacks
    National Center for Environmental Assessment, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 119:446-54. 2011
    ....
  46. pmc Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth
    Carrie V Breton
    Department of Preventive Medicine, USC Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Am J Respir Crit Care Med 183:243-8. 2011
    ..Glutathione plays an important role in antioxidant and inflammatory processes in the lung. Alterations in glutathione metabolism are a central feature of several chronic lung diseases...
  47. pmc Do the health benefits of cycling outweigh the risks?
    Jeroen Johan de Hartog
    University of Utrecht, Institute for Risk Assessment Sciences, Utrecht, The Netherlands
    Environ Health Perspect 118:1109-16. 2010
    ..a societal point of view a modal shift from car to bicycle may have beneficial health effects due to decreased air pollution emissions, decreased greenhouse gas emissions, and increased levels of physical activity, shifts in individual ..
  48. pmc Traffic-related air pollution and incident type 2 diabetes: results from the SALIA cohort study
    Ursula Kramer
    Institut fur umweltmedizinische Forschung IUF, Leibniz Center at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Environ Health Perspect 118:1273-9. 2010
    Cross-sectional and ecological studies indicate that air pollution may be a risk factor for type 2 diabetes, but prospective data are lacking.
  49. ncbi Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project
    Rob Beelen
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands Electronic address
    Lancet 383:785-95. 2014
    Few studies on long-term exposure to air pollution and mortality have been reported from Europe...
  50. ncbi Acute effects of particulate air pollution on respiratory admissions: results from APHEA 2 project. Air Pollution and Health: a European Approach
    R W Atkinson
    Department of Public Health Sciences, St George s Hospital Medical School, London, United Kingdom
    Am J Respir Crit Care Med 164:1860-6. 2001
    ....
  51. ncbi Time-to-event analysis of fine particle air pollution and preterm birth: results from North Carolina, 2001-2005
    Howard H Chang
    Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 175:91-8. 2012
    Exposure to air pollution during pregnancy has been suggested to be a risk factor for preterm birth; however, epidemiologic evidence remains mixed and limited...
  52. pmc Prospective study of particulate air pollution exposures, subclinical atherosclerosis, and clinical cardiovascular disease: The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air)
    Joel D Kaufman
    Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, USA
    Am J Epidemiol 176:825-37. 2012
    The Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air) was initiated in 2004 to investigate the relation between individual-level estimates of long-term air pollution exposure and the progression of subclinical ..
  53. ncbi Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, United States
    Sci Total Environ 448:66-71. 2013
    ..transported to an urban location for 5 consecutive days (exposure-block) of daily 4- to 5-hour-long ambient air pollution exposures...
  54. ncbi Cardiovascular effects of particulate air pollution exposure: time course and underlying mechanisms
    J P Langrish
    BHF University Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    J Intern Med 272:224-39. 2012
    b>Air pollution is now recognized as an important independent risk factor for cardiovascular morbidity and mortality and may be responsible for up to 3 million premature deaths each year worldwide...
  55. ncbi Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs
    LILIAN CALDERON-GARCIDUENAS
    Instituto Nacional de Pediatria, Mexico City, Mexico
    Brain Cogn 68:117-27. 2008
    Exposure to air pollution is associated with neuroinflammation in healthy children and dogs in Mexico City. Comparative studies were carried out in healthy children and young dogs similarly exposed to ambient pollution in Mexico City...
  56. pmc In-traffic air pollution exposure and CC16, blood coagulation, and inflammation markers in healthy adults
    Moniek Zuurbier
    Public Health Services Gelderland Midden, Arnhem, The Netherlands
    Environ Health Perspect 119:1384-9. 2011
    Exposure to traffic-related air pollution is a risk factor for cardiovascular events, probably involving mechanisms of inflammation and coagulation...
  57. ncbi Estimating the national public health burden associated with exposure to ambient PM2.5 and ozone
    Neal Fann
    U S Environmental Protection Agency, Office of Air Quality Planning and Standards, Research Triangle Park, NC, USA
    Risk Anal 32:81-95. 2012
    ..drawn from the long-term American Cancer Society (ACS) cohort study and National Mortality and Morbidity Air Pollution Study (NMMAPS), respectively, we estimate 130,000 PM(2...
  58. ncbi microRNAs: implications for air pollution research
    Melanie J Jardim
    National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Chapel Hill, NC, USA
    Mutat Res 717:38-45. 2011
    ..to air pollutants and to contemplate on how these responses ultimately control susceptibility to ambient air pollution. Morbidity and mortality attributable to air pollution continues to be a growing public health concern ..
  59. ncbi Air pollution, blood pressure, and the risk of hypertensive complications during pregnancy: the generation R study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hypertension 57:406-12. 2011
    Exposure to air pollution is associated with elevated blood pressure and cardiovascular disease...
  60. pmc Season, sex, age, and education as modifiers of the effects of outdoor air pollution on daily mortality in Shanghai, China: The Public Health and Air Pollution in Asia (PAPA) Study
    Haidong Kan
    Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
    Environ Health Perspect 116:1183-8. 2008
    Various factors can modify the health effects of outdoor air pollution. Prior findings about modifiers are inconsistent, and most of these studies were conducted in developed countries.
  61. pmc Public Health and Air Pollution in Asia (PAPA): a multicity study of short-term effects of air pollution on mortality
    Chit Ming Wong
    Department of Community Medicine, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China
    Environ Health Perspect 116:1195-202. 2008
    Although the deleterious effects of air pollution from fossil fuel combustion have been demonstrated in many Western nations, fewer studies have been conducted in Asia...
  62. pmc Fine particle sources and cardiorespiratory morbidity: an application of chemical mass balance and factor analytical source-apportionment methods
    Jeremy A Sarnat
    Rollins School of Public Health of Emory University, Department of Environmental and Occupational Health, 1518 Clifton Rd, Room 260, Atlanta, GA 30322, USA
    Environ Health Perspect 116:459-66. 2008
    ..We analyzed a time-series of chemically speciated PM measurements in Atlanta, Georgia, and conducted an epidemiologic analysis using data from three distinct source-apportionment methods...
  63. pmc Diabetes incidence and long-term exposure to air pollution: a cohort study
    Zorana J Andersen
    1Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Diabetes Care 35:92-8. 2012
    Animal and cross-sectional epidemiological studies suggest a link between air pollution and diabetes, whereas the limited prospective data show mixed results...
  64. ncbi Association between long-term exposure to outdoor air pollution and mortality in China: a cohort study
    Jie Cao
    Cardiovascular Institute and Fu Wai Hospital of the Chinese Academy of Medical Sciences and Peking Union Medical College, and Chinese National Center for Cardiovascular Disease Control and Research, Beijing, China
    J Hazard Mater 186:1594-600. 2011
    No prior cohort studies exist in China examining the association of outdoor air pollution with mortality. We studied 70,947 middle-aged men and women in the China National Hypertension Survey and its follow-up study...
  65. pmc Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California 92617, USA
    Environ Health Perspect 117:1232-8. 2009
    Mechanisms involving oxidative stress and inflammation have been proposed to explain associations of ambient air pollution with cardiovascular morbidity and mortality...
  66. pmc Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-ethnic Study of Atherosclerosis (MESA)
    Amy H Auchincloss
    Department of Epidemiology, School of Public Health, University of Michigan, 109 Observatory St, SPH Tower Room 3655, Ann Arbor, MI 48109 2029, USA
    Environ Health Perspect 116:486-91. 2008
    ..5 microm in aerodynamic diameter; PM(2.5)) and BP: systolic (SBP), diastolic (DBP), mean arterial (MAP), and pulse pressure (PP)...
  67. pmc Modeling the association between particle constituents of air pollution and health outcomes
    Elizabeth Mostofsky
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Am J Epidemiol 176:317-26. 2012
    ..5. Although the different methods yield results with different interpretations, the relative rankings of the association between constituents and ischemic stroke were fairly consistent across models...
  68. ncbi Ambient air pollution and preterm birth in the environment and pregnancy outcomes study at the University of California, Los Angeles
    Beate Ritz
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095, USA
    Am J Epidemiol 166:1045-52. 2007
    ..information to assess the extent to which residual confounding and exposure misclassification may impact air pollution effect estimates...
  69. ncbi From particles to patients: oxidative stress and the cardiovascular effects of air pollution
    Mark R Miller
    BHF University Centre for Cardiovascular Science, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh, Scotland, UK
    Future Cardiol 8:577-602. 2012
    b>Air pollution, especially airborne particulate matter (PM), is associated with an increase in both morbidity and mortality from cardiovascular disease, although the underlying mechanisms remain incompletely established...
  70. pmc Ambient temperature, air pollution, and heart rate variability in an aging population
    Cizao Ren
    Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Am J Epidemiol 173:1013-21. 2011
    Studies show that ambient temperature and air pollution are associated with cardiovascular disease and that they may interact to affect cardiovascular events...
  71. pmc Association between changes in air pollution levels during the Beijing Olympics and biomarkers of inflammation and thrombosis in healthy young adults
    David Q Rich
    Department of Community and Preventive Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA
    JAMA 307:2068-78. 2012
    b>Air pollution is a risk factor for cardiovascular diseases (CVD), but the underlying biological mechanisms are not well understood.
  72. ncbi Extreme air pollution events from bushfires and dust storms and their association with mortality in Sydney, Australia 1994-2007
    Fay Johnston
    Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart 7001, Tasmania, Australia
    Environ Res 111:811-6. 2011
    Extreme air pollution events due to bushfire smoke and dust storms are expected to increase as a consequence of climate change, yet little has been published about their population health impacts...
  73. ncbi Attention-deficit hyperactivity disorder in children chronically exposed to high level of vehicular pollution
    Shabana Siddique
    Health Canada, Environmental Health Center EHC, HECS, Tunneys Pasture, AL 0800C, Ottawa, K1A 0K9, ON, Canada
    Eur J Pediatr 170:923-9. 2011
    The purpose of this study is to explore whether sustained exposure to vehicular air pollution affects the behavior and activities of children...
  74. pmc Distributed lag analyses of daily hospital admissions and source-apportioned fine particle air pollution
    Ramona Lall
    New York University, School of Medicine, Department of Environmental Medicine, Tuxedo, New York 10987, USA
    Environ Health Perspect 119:455-60. 2011
    ..5 µm (PM2.5)] have used chemically nonspecific PM2.5 mass. However, PM2.5 is known to vary in chemical composition with source, and health impacts may vary accordingly...
  75. ncbi Air pollution, lung function, and physical symptoms in communities near concentrated Swine feeding operations
    Leah Schinasi
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
    Epidemiology 22:208-15. 2011
    ..We examined associations of reported hog odor and of monitored air pollutants with physical symptoms and lung function in people living within 1.5 miles of hog operations...
  76. pmc Ambient air pollution and birth weight in full-term infants in Atlanta, 1994-2004
    Lyndsey A Darrow
    Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Environ Health Perspect 119:731-7. 2011
    An emerging body of evidence suggests that ambient levels of air pollution during pregnancy are associated with fetal growth.
  77. pmc Ambient air pollution and low birth weight in Connecticut and Massachusetts
    Michelle L Bell
    School of Forestry and Environmental Studies, Yale University, New Haven, Connecticut 06511, USA
    Environ Health Perspect 115:1118-24. 2007
    Several studies have examined whether air pollution affects birth weight; however results vary and many studies were focused on Southern California or were conducted outside of the United States.
  78. ncbi Air pollution, platelet activation and atherosclerosis
    Parinaz Poursafa
    Tehran Azad University, Science and Research Branch, Tehran, Iran
    Inflamm Allergy Drug Targets 9:387-92. 2010
    ..The role of environmental factors, including air pollution, remains overlooked...
  79. pmc Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study
    ROBIN C PUETT
    South Carolina Cancer Prevention and Control Program and Department of Epidemiology, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29201, USA
    Environ Health Perspect 117:1697-701. 2009
    The relationship of fine particulate matter < 2.5 microm in diameter (PM(2.5)) air pollution with mortality and cardiovascular disease is well established, with more recent long-term studies reporting larger effect sizes than earlier ..
  80. ncbi Air pollution and birth outcomes: a systematic review
    Prakesh S Shah
    Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada
    Environ Int 37:498-516. 2011
    ....
  81. pmc Air pollution and emergency admissions in Boston, MA
    Antonella Zanobetti
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    J Epidemiol Community Health 60:890-5. 2006
    Many studies have shown that ambient particulate air pollution (PM) is associated with increased risk of hospital admissions and deaths for cardiovascular or respiratory causes around the world...
  82. pmc Global estimates of ambient fine particulate matter concentrations from satellite-based aerosol optical depth: development and application
    Aaron van Donkelaar
    Department of Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada
    Environ Health Perspect 118:847-55. 2010
    ..5 microm (PM2.5) are limited by the lack of monitoring data, especially in developing countries. Satellite observations offer valuable global information about PM2.5 concentrations...
  83. ncbi Referent selection in case-crossover analyses of acute health effects of air pollution
    D Levy
    Department of Epidemiology, University of Washington, Seattle 98195-7232, USA
    Epidemiology 12:186-92. 2001
    ..be an alternative to Poisson time series regression for studying the health effects of fine particulate matter air pollution. Characteristics of time-series of particulate matter, including long-term time trends, seasonal trends, and ..
  84. ncbi Long-term exposure to road traffic noise and myocardial infarction
    Jenny Selander
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm University, Stockholm, Sweden
    Epidemiology 20:272-9. 2009
    ..No previous study has simultaneously analyzed the role of exposure to noise and air pollution from road traffic in the risk of MI.
  85. ncbi Traffic-related air pollution and the development of asthma and allergies during the first 8 years of life
    Ulrike Gehring
    Institute for Risk Assessment Sciences, Utrecht University, The Netherlands
    Am J Respir Crit Care Med 181:596-603. 2010
    The role of air pollution exposure in the development of asthma, allergies, and related symptoms remains unclear, due in part to the limited number of prospective cohort studies with sufficiently long follow-ups addressing this problem.
  86. pmc Ambient air pollution and adverse birth outcomes: methodologic issues in an emerging field
    Beate Ritz
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA 90095 1772, USA
    Basic Clin Pharmacol Toxicol 102:182-90. 2008
    ..Findings from our recent study in Southern California indicate that air pollution effect estimates are not markedly influenced by risk factors not provided on birth certificates...
  87. ncbi Chronic obstructive pulmonary disease and long-term exposure to traffic-related air pollution: a cohort study
    Zorana J Andersen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Am J Respir Crit Care Med 183:455-61. 2011
    Short-term exposure to air pollution has been associated with exacerbation of chronic obstructive pulmonary disease (COPD), whereas the role of long-term exposures on the development of COPD is not yet fully understood.
  88. ncbi Interactive effects of antioxidant genes and air pollution on respiratory function and airway disease: a HuGE review
    Cosetta Minelli
    Institute of Genetic Medicine, EURAC research, Viale Druso 1, 39100 Bolzano, Italy
    Am J Epidemiol 173:603-20. 2011
    Susceptibility to the respiratory effects of air pollution varies between individuals...
  89. ncbi Exposure to severe urban air pollution influences cognitive outcomes, brain volume and systemic inflammation in clinically healthy children
    LILIAN CALDERON-GARCIDUENAS
    Instituto Nacional de Pediatria, Mexico City 04530, Mexico
    Brain Cogn 77:345-55. 2011
    Exposure to severe air pollution produces neuroinflammation and structural brain alterations in children...
  90. pmc Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
    Carole Yauk
    Environmental and Occupational Toxicology Division, HECSB, Ottawa, ON, Canada K1A 0K9
    Proc Natl Acad Sci U S A 105:605-10. 2008
    Particulate air pollution is widespread, yet we have little understanding of the long-term health implications associated with exposure...
  91. ncbi Simultaneously mitigating near-term climate change and improving human health and food security
    Drew Shindell
    NASA Goddard Institute for Space Studies and Columbia Earth Institute, Columbia University, New York, NY 10025, USA
    Science 335:183-9. 2012
    ..5°C by 2050. This strategy avoids 0.7 to 4.7 million annual premature deaths from outdoor air pollution and increases annual crop yields by 30 to 135 million metric tons due to ozone reductions in 2030 and beyond...
  92. pmc Air pollution exposure during pregnancy, ultrasound measures of fetal growth, and adverse birth outcomes: a prospective cohort study
    Edith H van den Hooven
    Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health Perspect 120:150-6. 2012
    b>Air pollution exposure during pregnancy might have trimester-specific effects on fetal growth.
  93. pmc Particulate matter exposures, mortality, and cardiovascular disease in the health professionals follow-up study
    ROBIN C PUETT
    South Carolina Cancer Prevention and Control Program and Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA
    Environ Health Perspect 119:1130-5. 2011
    The association of all-cause mortality and cardiovascular outcomes with air pollution exposures has been well established in the literature...
  94. pmc Association of traffic-related air pollution with children's neurobehavioral functions in Quanzhou, China
    Shunqin Wang
    Department of Occupational and Environmental Health Science, School of Public Health, Peking University, Beijing, People s Republic of China
    Environ Health Perspect 117:1612-8. 2009
    With the increase of motor vehicles, ambient air pollution related to traffic exhaust has become an important environmental issue in China...
  95. pmc Traffic-related air toxics and term low birth weight in Los Angeles County, California
    Michelle Wilhelm
    Department of Epidemiology, School of Public Health, University of California Los Angeles, 650 Charles E Young Dr, Los Angeles, CA 90095, USA
    Environ Health Perspect 120:132-8. 2012
    ..Numerous studies have linked criteria air pollutants with adverse birth outcomes, but there is less information on the importance of specific emission sources, such as traffic, and air toxics...
  96. pmc Association between local traffic-generated air pollution and preeclampsia and preterm delivery in the south coast air basin of California
    Jun Wu
    Program in Public Health, College of Health Sciences, University of California, Irvine, California 92697 7555, USA
    Environ Health Perspect 117:1773-9. 2009
    ..Increasing evidence suggests that air pollution adversely affects pregnancy outcomes...
  97. pmc Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice
    Ece A Mutlu
    Department of Medicine, Section of Gastroenterology and Nutrition Rush University Medical College, 1725 W Harrison Street, Chicago, IL 60612, USA
    Part Fibre Toxicol 8:19. 2011
    Exposure to particulate matter (PM) air pollution may be an important environmental factor leading to exacerbations of inflammatory illnesses in the GI tract...
  98. pmc Traffic-related air pollution and acute changes in heart rate variability and respiratory function in urban cyclists
    Scott Weichenthal
    Air Health Sciences Division, Health Canada, Ottawa, Canada
    Environ Health Perspect 119:1373-8. 2011
    Few studies have examined the acute health effects of air pollution exposures experienced while cycling in traffic.
  99. ncbi Associations between cigarette smoking, obesity, sociodemographic characteristics and remote-sensing-derived estimates of ambient PM2.5: results from a Canadian population-based survey
    Paul J Villeneuve
    Population Studies Division, Health Canada, 50 Columbine Driveway, Room 165, PL0801A, Ottawa, ON K1A 0K9, Canada
    Occup Environ Med 68:920-7. 2011
    ..has been shown to increase mortality. Variables measured on the same spatial scales of air pollution may confound associations, and so the authors' objectives were to evaluate the associations between PM2...
  100. ncbi Long-term exposure to traffic-related air pollution and mortality in Shizuoka, Japan
    Takashi Yorifuji
    Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama City, Okayama Pref 700 8558, Japan
    Occup Environ Med 67:111-7. 2010
    The number of studies investigating the health effects of long-term exposure to air pollution is increasing, however, most studies have been conducted in Western countries...
  101. pmc Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution
    Cizao Ren
    Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 21:198-206. 2010
    ..nondeletion), and HMOX-1 (any short vs. both long). We attempted to replicate identified genes in an analysis of heart rate variability and in other outcomes reported in the literature...

Research Grants73

  1. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2013
    ..To investigate if air pollution exposure contributes to adiposity and inflammation in adipose tissues that induces insulin resistance and ..
  2. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..Roby Greenwald, are to examine the respiratory response to inhaled oxidants, specifically, the influence of air pollution mixtures on markers of airway inflammation and oxidative stress...
  3. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..Although multiple factors influence birth weight and size, air pollution exposure during pregnancy has been recently explored as a contributor...
  4. Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?
    Qinghua Sun; Fiscal Year: 2010
    ..To investigate if air pollution exposure contributes to adiposity and inflammation in adipose tissues that induces macro- and microvascular ..
  5. Endotoxin, the airway transcriptome, and obstructive lung disease
    PEGGY SUE LAI; Fiscal Year: 2013
    ..in the context of various occupations especially cotton textile work, and more recently as part of indoor air pollution in schools. We do not fully understand how endotoxin can lead to development or worsening of asthma and COPD...
  6. Climate Change and Adverse Birth Outcomes: Assessing the Vulnerability of Pregnan
    Shao Lin; Fiscal Year: 2013
    ..To assess acclimatization and potential modification by air pollution, we will examine geographic variation and interactive effects of air pollution on the associations tested...
  7. Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
    BRITT HOLMEN; Fiscal Year: 2010
    ..Since the 1970's, adverse health effects have been reported at unexpectedly low levels of particulate air pollution, leading scientists and public health officials to conclude that long-term exposure to combustion-related fine ..
  8. Interactions of Diesel Exhaust and Respiratory Viruses in Asthmatic Children
    Toby C Lewis; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Traffic-associated air pollution and respiratory viral infections (URIs) are well-documented, independent stimulants of asthma symptoms, and both are associated with significant asthma morbidity...
  9. Endothelial Progenitor Cells and Particulate Air Pollution
    Arden Pope; Fiscal Year: 2013
    ..by applicant): Multiple epidemiological and experimental studies report that acute or chronic exposure to air pollution is associated with adverse cardiovascular events including myocardial ischemia, stroke, arrhythmias, heart ..
  10. Air Pollution, Inflammation and Preterm Birth: A Mechanistic Study in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2012
    ..A recent Institute of Medicine Report notes that air pollution exposure may be a significant cause of prematurity, but most published studies are based on population birth ..
  11. Gene expression responses to air pollution and modification by genetic variation
    Sharine Wittkopp; Fiscal Year: 2013
    ..Epidemiological studies have shown that exposure to ambient particulate matter (PM) air pollution is associated with increases in cardiovascular morbidity and mortality...
  12. Environment, Novel Aging Outcomes, and Genetics
    Sung Kyun Park; Fiscal Year: 2013
    ..The scientific goals of this project are to understand how long term environmental exposures to lead and air pollution affect age-related pathological changes, namely, depressed cardiac function, and two novel outcomes that have ..
  13. ENHANCEMENT OF CORONARY CONSTRICTION BY COMBUSTION-SOURCE AIR TOXICS
    Matthew J Campen; Fiscal Year: 2012
    b>Air pollution is positively associated with an increased daily incidence of myocardial infarction and cardiovascular mortality...
  14. PROJECTED HEAT WAVE MAGNITUDES AND PUBLIC HEALTH IMPACTS
    Helene G Margolis; Fiscal Year: 2010
    ..g., heat, air pollution, and co- morbidity), rather than only examine risk in the context of single (or limited number) exposure-..
  15. Bangladesh Centre for Global Environmental and Occupational Health
    Dewan Shamsul Alam; Fiscal Year: 2013
    ..e., water pollution, climate change, and air pollution), which are escalating as public health priorities in the country...
  16. A geostatistical framework for the multi-scale boundary analysis of space-time tr
    PIERRE E GOOVAERTS; Fiscal Year: 2013
    ..g. mammography clinics), socio-economic status, air pollution, and individual-level factors (e.g. smoking, health insurance, age)...
  17. Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth
    MICHELLE WILHELM TURNER; Fiscal Year: 2010
    ..the growing literature reporting increased risks of adverse birth outcomes for women highly exposed to outdoor air pollution during pregnancy, the most important questions remain unanswered;specifically, what are the relevant sources ..
  18. Role of TRP Channels in Environmental Irritant-Induced Headache
    Gerry S Oxford; Fiscal Year: 2013
    ..provided by applicant): Headache is one of the most frequent complaints attributed to environmental air pollution (indoor and outdoor), but the total impact on public health is difficult to quantify...
  19. Measuring Tobacco Mortality within the Million Death Study in India
    Prabhat Jha; Fiscal Year: 2010
    ..gt;Quantify the effects of household male smoking and indoor air pollution among about 3,500 childhood respiratory deaths and about 7,500 adult female respiratory deaths...
  20. MULTIDISCIPLINARY TRAINING IN PULMONARY RESEARCH
    MARK WALTER FRAMPTON; Fiscal Year: 2013
    ..fibrosis and remodeling;tobacco smoke and chronic obstructive pulmonary disease;and health effects of air pollution. Four predoctoral and 4 postdoctoral trainees will be supported each year of the program...
  21. Air pollution and the brain: gender as an important determinant of susceptibility
    Lucio G Costa; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The association between air pollution and morbidity and mortality caused by respiratory and cardiovascular diseases is well established;in addition, initial evidence suggests that air pollution may ..
  22. Impact of obesity on airway responses to air pollution
    Stephanie A Shore; Fiscal Year: 2013
    ..Understanding the mechanistic basis for the augmented pulmonary responses to air pollution may lead to new therapeutic strategies for this increasingly at risk population.
  23. Diesel Exhaust Particle Effects on Human Immunity to Mycobacterium tuberculosis
    Stephan K Schwander; Fiscal Year: 2010
    b>Air pollution and tuberculosis (TB) each present major challenges to public health and specifically to lung health globally...
  24. Clinical trial of air cleaners to improve indoor air quality and COPD health
    Nadia N Hansel; Fiscal Year: 2013
    ..Although outdoor air pollution has known adverse effects on COPD morbidity and mortality, the indoor environment is of particular concern as ..
  25. Mechanisms of airborne particulate matter induced thrombosis
    Gokhan M Mutlu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Exposure to ambient particulate matter (PM) air pollution accounts up to 3.1 years of life lost in the most compared with the least polluted US cities...
  26. Cardiovascular Effects of Ultrafine Particles in Genetically Susceptible Subjects
    Mark W Frampton; Fiscal Year: 2010
    ..and genetic determinants of susceptibility represent gaps in our understanding of the health effects of PM air pollution. Ultrafine particles (UFP, <100 nm diameter) may be particularly important with regard to cardiovascular ..
  27. Histone modifications and respiratory effects of traffic particle exposure
    Lifang Hou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Air pollution is a major public health concern, accounting for ~800,000 annual deaths...
  28. Cardiovascular Health: Effects of the Social and Physical Environment
    Shakira Franco Suglia; Fiscal Year: 2013
    ..e., increased violence exposure), physical (i.e., higher air pollution levels, poor access to recreational facilities and access to fresh fruits and vegetables) and behavioral (i.e...
  29. Environmental Determinants of Cognitive Aging in the WHI Memory Study
    Jiu Chiuan Chen; Fiscal Year: 2013
    ..Over the last decade, scientific research has repeatedly shown that ambient air pollution increases cardiovascular disease (CVD) risk and mortality...
  30. Inhibition of lung defense by air pollutant particulates
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    Fine particulate air pollution is associated with an increased mortality due to respiratory infection and cardiovascular disease...
  31. Effects of ozone exposure on expression and function of surfactant protein D
    Angela Haczku; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Air pollution, particularly O3, induces exacerbations of asthma that substantially worsen morbidity and mortality...
  32. International Training and Research in Environmental and Occupational Health
    NELSON K STEENLAND; Fiscal Year: 2012
    ..Indoor air pollution is a particular problem in both Chile and Peru where large numbers of people lack effective stoves and ..
  33. Obesity Development: Role of Air Pollution and High Fat Diet
    Qinghua Sun; Fiscal Year: 2010
    ..Epidemiological studies have demonstrated that exposure to air pollution, in particular ambient fine particulate matter (<2.5 ?m, PM2...
  34. Ozone Cardiovascular Effects in Genetically Susceptible People
    MARK WALTER FRAMPTON; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Increases in air pollution are associated with increases in deaths from cardiovascular disease, but we know little about how ozone air ..
  35. The Association of Chronic Exposure to Particulate Matter Air Pollutants, Inflamm
    RODRIGO XAVIER ARMIJOS; Fiscal Year: 2013
    ..understanding of the impact of transient and longer- term exposure to particulate matter present in urban air pollution on the cardiovascular health of children...
  36. Training in Environmental Health to Reduce Chronic Disease in Latin America
    Philip J Landrigan; Fiscal Year: 2013
    ..chronic disease in children is caused or aggravated by environmental factors including indoor allergens, air pollution and tobacco smoke;2) obesity and diabetes are epidemic in developed countries and are increasing alarmingly in ..
  37. Prenatal diet, PM2.5 and programming of the infant autonomic response
    Rosalind J Wright; Fiscal Year: 2013
    ..factors gaining attention with respect to fetal programming and autonomic disruption include particulate air pollution and maternal diet (e.g., oxidant/antioxidant balance)...
  38. Impact of an Indoor Stove Intervention on Indicators of Cardiorespiratory Health
    Jennifer L Peel; Fiscal Year: 2012
    ..and poorly vented indoor cook stoves to meet these needs, which can result in extremely high indoor air pollution concentrations...
  39. Enhancement of Coronary Constriction by Volatile Organic Air Toxics
    Matthew J Campen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Air pollution, especially particulate matter (PM), has a substantial impact on global health, with the World Health Organization estimating 800,000 annual excess cardiopulmonary deaths through ..
  40. Micro-RNA Profiling and Cardiovascular Effects of Traffic Particle Exposure
    Lifang Hou; Fiscal Year: 2012
    Abstract Air pollution is a major public health concern in the US and worldwide. Exposure to air particulate matter (PM) with an aerodynamic diameter <2.5 [unreadable]m (PM2...
  41. Ozone, apoE4, aging, and Alzheimer's disease
    Rui Ming Liu; Fiscal Year: 2013
    ..Interestingly, it has been reported that children and young adults living in urban areas with high levels of air pollution including O3 exhibited AD-like pathology in their brain...
  42. Climate Change and Health: Assessing the Risk of Preterm Delivery
    Rupa Basu; Fiscal Year: 2013
    ..Yet the etiology remains largely unknown. Studies of air pollution and seasonal trends have supported a relationship between adverse birth outcomes, such as PTD, thus supporting ..
  43. Heat Waves, Medication Use, and Adverse Health Outcomes Among Older Adults
    SOKO SETOGUCHI-IWATA; Fiscal Year: 2013
    ..analyses, we will link several existing data sources, including temperature, humidity, heat index, and air pollution data, data on health care resource use in the Medicare program, and longitudinal data on pharmacy dispensing...
  44. Healthy Worker Effect, Occupational Exposure to PM and Cardiopulmonary Mortality
    ELLEN AURA EISEN; Fiscal Year: 2013
    ..5) of traffic-related air pollution, a well established cardiovascular hazard...
  45. Transcriptomic, Oxidative Stress, and Inflammatory Responses to Air Pollutants
    Ralph J Delfino; Fiscal Year: 2013
    ..provided by applicant): Short-term exposures to US EPA-regulated atmospheric particulate matter (PM) air pollution with diameters <2.5 um (PM2...
  46. Single Cell Analysis of EGFR Activity in Human Airway Cells Exposed to Pollutants
    RYAN MATTHEW PHILLIPS; Fiscal Year: 2013
    ..that will permit analysis of such samples, and will provide important information about the link between air pollution, lung inflammation, and heart disease...
  47. Black carbon exposure, DNA methylation, airway inflammation in pediatric asthma
    Rachel L Miller; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Exposure to traffic-related air pollution is associated with asthma exacerbations among children. Symptomatic adolescents tend to develop persistent disease...
  48. The Charge Study: Childhood Autism Risks from Genetics and the Environment
    Irva Hertz-Picciotto; Fiscal Year: 2013
    ..Fieldwork began in 2003, and by now CHARGE has published widely on exposures such as air pollution, mercury, flame retardants, maternal nutritional status in the peri-conception, untreated fever during ..
  49. Maternal and Child Health Benefits from Reducing Household Air Pollution
    Patricia L Hibberd; Fiscal Year: 2013
    ..consortium proposes to develop is based on their current GN studies on the adverse effects of Household Air Pollution (HAP) on pregnancy and infant outcomes...
  50. Air pollution and fetal growth in China
    Yawei Zhang; Fiscal Year: 2013
    ..on birth outcomes (such as birth weight and preterm birth), very few studies, however, have investigated air pollution in relation to fetal growth measured through ultrasound, a sensitive index and novel approach to examine how ..
  51. Reducing Social Disparities of Heatwave Impacts in a Changing Climate
    MARIE SYLVIA O apos NEILL; Fiscal Year: 2010
    ..to which they differ in their associations with excess daily mortality by population group, accounting for air pollution. Through the community action plan, recommendations from the evaluation of results will be shared with ..
  52. Air Pollution Particle Effects on Human Antimycobacterial Immunity
    Stephan K Schwander; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Air pollution and tuberculosis (TB) each contribute significantly to global disease burden as deteriorating air quality from rapid industrial growth and traffic collide with high levels of endemic TB ..
  53. Body Burden of PAHs and Cardiovascular Disease in the United States
    JOHN DAVIS CLARK; Fiscal Year: 2010
    ..Considering the number of deaths attributable to tobacco smoke exposure, ambient air pollution, and occupational hazards, PAHs may be a significant contributor to the high prevalence and mortality rate of ..
  54. Role of the Indoor Environment on Oxidative Stress Related Sinonasal Inflammation
    Murugappan Ramanathan; Fiscal Year: 2013
    ..Dr. Ramanathan will enhance his research knowledge and skills with coursework in environmental health and air pollution, receive directed mentorship by an interdisciplinary team of experienced researchers, and be immersed in the ..
  55. Particle-Induced Cardiac Effects in Senescent Mice
    Clarke Tankersley; Fiscal Year: 2009
    ..biological mechanisms remain elusive to explain the association between daily fluctuations in ambient air pollution and increased mortality rates...
  56. Traffic and Respiratory Health
    Brian P Leaderer; Fiscal Year: 2013
    ..Traffic, which has been steadily increasing over the past two decades, represents an important local source of air pollution, with "local" most likely encompassing a smaller area (e.g...
  57. A Translational Framework for Methodological Rigor to Improve Patient Centered Ou
    Francesca Dominici; Fiscal Year: 2013
    ..Hopkins University, 1999-2009, I have developed statistical methods for the analysis of large databases on air pollution and health (see item 2)...
  58. Community-based Participatory Research: A Tool to Advance Cookstove Interventions
    MAGGIE LYNN CLARK; Fiscal Year: 2013
    ..by applicant): The goal of this Career Development Award is to initiate an independent research program in air pollution epidemiology, exploring the dynamic relationship between environmental and social/behavioral risk factors on ..
  59. Biological Response to Air Quality Change in Beijing pre-, mid- and post-Olympics
    Lina Mu; Fiscal Year: 2013
    ..in Beijing during the 2008 Olympics created a unique natural experiment with an initial dramatic decline in air pollution concentrations followed by a return to pre- Olympic concentrations...
  60. Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
    Andrea Baccarelli; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Air pollution is a pervasive environmental threat estimated to cause ~800,000 deaths every year worldwide, mostly due to cardiovascular disease...
  61. Air Pollution and Cognitive Aging Among Older Women
    Jennifer Weuve; Fiscal Year: 2010
    ..In particular, indirect evidence suggests that chronic exposure to air pollution may be associated with cognitive decline...
  62. MULTIDISCIPLINARY ENVIRONMENTAL HEALTH TRAINING
    David Carpenter; Fiscal Year: 2006
    ..with either infectious or toxic substances, safe disposal of sewage, solid and hazardous wastes and air pollution. We propose a training program with an Albany-based faculty of epidemiologists, statisticians, toxicologists, ..
  63. Air Pollution and Adverse Birth Outcomes
    Beate Ritz; Fiscal Year: 2004
    ..of the human growth periods most vulnerable to toxins, epidemiologic data concerning the effects of ambient air pollution exposures during this period are limited...
  64. Tracking Air Pollutants and Newborn Health in Houston, Texas
    Elaine Symanski; Fiscal Year: 2011
    ..Greater Houston area (Harris County, Texas) provides a unique multi-ethnic study area to evaluate effects of air pollution on newborn health and resulting health disparities among racial/ethnic groups...
  65. SULFUR OXIDES EFFECTS ON LUNG FUNCTION IN ASTHMATICS
    Jane Koenig; Fiscal Year: 1991
    Epidemiologic studies have associated lung function decreases with summertime ambient air pollution described as "acid haze" which appears to be ozone (O3) combined with some acidic compounds...
  66. Air Pollution and Asthma in Southeast Louisiana
    BADIOLLAH ASRABADI; Fiscal Year: 2002
    ..4) Investigate and document the effect of sugarcane burning and other particulate air pollution on asthma. 5) Develop alternative strategies is dropped from the proposal...
  67. Ambient Air Toxics and Adverse Birth Outcomes
    MICHELLE WILHELM TURNER; Fiscal Year: 2010
    DESCRIPTION (provided by investigator): There is growing evidence that some air pollution constituents perturb fetal development. Some studies point to motor vehicle exhaust pollutants specifically as causative agents of interest...
  68. Historic Traffic Exposure Maps for Cancer Studies
    Paul English; Fiscal Year: 2003
    ..Recently, there have been calls for the development of exposure maps showing modeled concentrations of ambient air pollution using geographic information systems (GIS) to investigate long-term health effects...
  69. Air Pollution, Systemic Inflammation, and Sub-Clinical Atherosclerosis in High-Al
    RODRIGO XAVIER ARMIJOS; Fiscal Year: 2010
    ..children (7-12 years) living at high altitude who are exposed long-term to particulate matter (PM) in ambient air pollution develop systemic inflammation and oxidative stress leading to arterial wall thickening that can be measured ..
  70. EFFECTS OF AMBIENT AIR POLLUTANTS ON ANNUAL MORTALITY
    George Thurston; Fiscal Year: 2001
    ..5 and sulfate; 2) lung cancer mortality rates are enhanced by particulate air pollution; and 3) the mortality that has been associated with PM results in substantial life shortening...
  71. Ambient PM2.5 and ETS exposure: interactive health effects for asthmatic children
    Matthew J Strand; Fiscal Year: 2010
    Statistical models that allow for estimation of health effects of air pollution are well developed when only one pollutant is considered...
  72. TOXIC ALDEHYDES AS MODULATORS OF LUNG INFLAMMATION
    Albert van Der Vliet; Fiscal Year: 2007
    ..provided by applicant): Reactive aldehydes such as acrolein (2,3-propenal) are major components of air pollution and are proposed to contribute to the adverse effects of smoking in lung diseases such as chronic obstructive ..